Hub : Genes

Tk1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Tk1	0.17	0.1	6.1e-09	0.06	0.07	0.07	0.05	1.1e-07	2.3e-08	2.2e-08	1.8e-06
2	IL	alternative polyA	NM_052800.1	0.12	0.1	8.2e-03	0.03	0.03	0.06	0.03	6.8e-02	7.9e-02	1.3e-02	6.7e-02
3	Adipose	intron excision ratio	chr10_103045009_103045844	0.02	0.02	8.5e-03	0.01	0.01	0	0.01	1.8e-02	2.5e-02	2.5e-01	4.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.0	1.6	2.6	1.6	0.4	-1.4
Area under the delay curve	2.1	2.3	4.6	-0.1	-2.1	1.5
BMI with tail	1.4	4.4	8.3	-1.9	2.9	-1.2
BMI without tail	1.2	2.5	3.8	0.9	1.9	-1.7
Body weight	0.5	2.3	6.0	-2.5	0.4	0.8
Weight adjusted by age	0.0	0.1	0.1	-0.2	-0.3	0.1
Bone surface	1.2	2.2	5.7	0.5	-2.4	0.7
Bone volume	0.6	1.0	2.0	0.9	-1.4	-0.3
Breakpoint value in progressive ratio session	0.3	0.3	0.6	-0.6	0.2	-0.8
Number of licking bursts	0.0	0.1	0.1	0.1	-0.3	0.2
Context. condit. distance diff. score	0.1	0.1	0.2	-0.5	-0.4	0.1
Locomotion velocity, session 1	0.9	1.0	1.9	-0.3	-0.9	1.4
Locomotion distance, session 1	1.8	2.4	2.7	1.3	1.7	-1.6
Locomotion velocity, session 2	0.4	0.4	0.5	0.7	0.6	-0.7
Locomotion distance, session 2	4.5	6.3	6.9	2.3	2.6	-2.6
Locomotion velocity, session 3	0.4	0.4	0.7	0.3	-0.7	0.8
Locomotion distance, session 3	0.6	0.7	1.8	-0.1	1.3	-0.5
Stereotopy head waving bouts, day 3	1.6	1.9	3.2	-1.8	-1.2	1.1
Stereotopy head waving duration, day 3	1.7	2.1	2.7	-1.5	-1.6	1.1
Locomotion velocity, session 7	0.2	0.3	0.6	0.8	-0.4	0.0
Locomotion distance, session 7	2.7	3.4	4.4	1.9	1.5	-2.1
Stereotopy head waving bouts, day 7	3.0	3.4	3.8	-2.0	-1.7	1.8
Stereotopy head waving duration, day 7	5.2	6.3	7.5	-2.1	-2.7	2.6
Locomotion velocity, session 8	0.9	1.1	2.1	0.0	-1.5	1.1
Locomotion distance, session 8	2.3	3.4	4.7	1.5	1.8	-2.2
Degree of sensitization distance	2.9	2.9	5.9	2.4	0.2	-1.7
Degree of sensitization stereotypy	1.3	1.4	1.5	-1.2	-1.1	1.2
Conditioned locomotion	0.2	0.2	0.4	0.3	0.2	-0.6
Cocaine response after cond. corrected	0.2	0.3	0.7	-0.9	0.0	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.3	-0.4	0.3
Cocaine response before conditioning	0.7	0.9	1.6	1.3	-0.9	0.3
Saline control response	1.4	1.8	2.3	1.5	-1.2	1.2
Bone: connectivity density	1.3	2.1	5.3	2.3	0.3	-1.0
Bone: cortical apparent density	2.1	2.7	5.5	0.2	2.3	-1.6
Bone: cortical area	2.5	3.7	9.5	-3.1	-0.5	1.2
Bone: cortical porosity	2.0	2.2	3.0	-1.0	-1.7	1.6
Bone: cortical porosity	2.7	2.9	4.3	-1.1	-2.1	1.8
Bone: cortical thickness	2.4	4.0	6.7	-2.6	2.3	-0.0
Bone: cortical thickness	1.1	1.3	2.3	-1.5	1.3	-0.0
Bone: cortical tissue density	2.1	2.8	5.4	0.3	2.3	-1.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.6	-0.3	-0.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.7	-0.5	-0.3
Condit. Reinf. active responses	0.4	0.5	1.3	1.1	0.0	-0.4
Condit. Reinf. inactive responses	0.5	0.6	1.1	1.1	0.6	-0.5
Incentive salience index mean	0.2	0.2	0.3	0.5	-0.6	0.2
Condit. Reinf. lever presses	0.1	0.1	0.2	0.4	-0.3	-0.0
Condit. Reinf. active minus inactive responses	0.8	0.9	2.0	0.1	-1.4	0.9
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	0.2	-0.8	0.7
Condit. Reinf. active responses	0.1	0.2	0.3	0.6	-0.5	-0.2
Condit. Reinf. inactive responses	0.5	0.6	0.9	1.0	0.2	-0.8
Condit. Reinf. lever presses	0.8	1.1	2.1	1.5	0.1	-1.1
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	0.5	-0.1	-0.6
Conditioned reinforcement - actives	0.9	1.0	1.4	0.6	1.0	-1.2
Conditioned reinforcement - inactives	0.2	0.3	0.5	-0.7	-0.0	0.5
Conditioned locomotion	1.2	1.5	2.5	0.6	1.3	-1.6
Patch foraging indifference point 0 sec	0.7	1.1	1.8	0.9	0.8	-1.4
Patch foraging indifference point AUC	1.6	1.8	4.5	2.1	0.6	-0.7
Delay disc. indifference point, 0s delay	1.8	2.0	2.9	-0.6	-1.6	1.7
Delay disc. indifference point, 16s delay	0.3	0.3	0.7	0.9	-0.0	-0.4
Delay disc. indifference point, 2s delay	1.1	1.2	2.8	0.2	-1.7	0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	-0.4	0.1
Delay disc. indifference point, 4s delay	2.2	2.3	4.2	-0.2	-2.0	1.6
Delay disc. indifference point, 8s delay	5.0	5.1	8.3	-0.9	-2.9	2.5
Indifference point function ln k	1.3	1.8	3.0	-1.7	1.3	-0.7
Indifference point function log k	1.3	1.8	3.0	-1.7	1.3	-0.7
Patch foraging total patch changes 0 sec	1.0	1.6	2.7	1.1	1.1	-1.6
Patch foraging total patch changes 12 sec	2.9	3.8	5.2	2.3	1.7	-1.8
Patch foraging total patch changes 18 sec	2.0	2.6	5.8	2.4	0.2	-1.4
Patch foraging total patch changes 24 sec	0.6	0.7	1.6	0.5	-1.3	0.6
Patch foraging total patch changes 6 sec	1.6	2.3	2.8	1.7	1.4	-1.5
Patch foraging time to switch 0 sec	0.2	0.3	0.5	-0.5	-0.5	0.7
Patch foraging water rate 0 sec	0.4	0.7	1.1	1.1	0.3	-0.9
Patch foraging water rate 12 sec	1.5	2.2	4.0	-1.0	2.0	-1.3
Patch foraging water rate 18 sec	0.4	0.5	1.0	0.2	0.7	-1.0
Patch foraging water rate 24 sec	1.5	2.2	3.2	1.3	1.2	-1.8
Patch foraging water rate 6 sec	0.5	0.7	1.3	-0.7	1.2	-0.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	0.7	0.1	0.2
Distance traveled before self-admin	1.6	1.7	2.7	-0.5	-1.5	1.6
Distance traveled after self-admin	1.3	1.4	2.1	1.2	0.7	-1.5
Extensor digitorum longus weight	1.3	5.0	7.1	1.3	2.7	-2.5
Bone: elastic displacement	1.6	1.8	4.0	0.1	2.0	-1.2
Bone: elastic work	0.9	1.2	2.6	-1.6	1.0	-0.0
Bone: endosteal estimation	1.2	2.7	7.7	-0.3	-2.8	0.4
Bone: endosteal perimeter	4.4	9.2	20.5	-1.5	-4.5	2.2
Epididymis fat weight	0.4	0.9	1.4	-1.2	1.0	-0.6
Delta time in closed arm before/after self-admin	0.7	0.7	1.3	0.1	-1.1	0.8
Delta time in open arm before/after self-admin	0.8	0.8	1.5	1.2	0.5	-0.8
Diff in mean of infusions in LGA sessions	0.4	0.5	0.8	-0.9	-0.8	-0.2
Delay discount exponential model param	2.5	2.7	5.3	0.2	2.3	-1.6
Extinction: sum of active levers before priming	0.2	0.2	0.3	-0.5	0.5	-0.3
Active lever presses in extinction session 6	0.6	0.6	1.0	-0.1	1.0	-0.8
Bone: final force	1.0	1.6	3.5	-1.9	-0.3	1.1
Bone: final moment	1.1	1.7	4.0	-2.0	-0.4	1.1
Food consumed during 24 hour testing period	0.9	1.1	1.9	1.0	-1.4	0.7
Glucose	0.3	0.4	0.8	-0.5	0.9	-0.4
Heart weight	1.1	1.5	2.9	-1.7	1.2	-0.3
Delay discount hyperbolic model param	2.3	2.5	5.0	0.2	2.2	-1.5
Intermittent access intake day 1-15 change	0.5	0.5	1.0	0.3	-0.6	1.0
Intermittent access intake escalation	0.5	0.5	0.6	0.7	-0.7	0.8
Intermittent access intake escalation 2	0.3	0.3	0.9	1.0	-0.1	0.2
Intermitt. access day 1 inactive lever presses	2.1	2.2	2.6	-1.3	-1.5	1.6
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.7	0.8	0.3	-0.3
Intermitt. access escalation Index	1.2	1.1	2.0	-0.1	-1.4	1.1
Intermittent access day 1 total infusions	0.5	0.5	1.1	-1.1	0.5	-0.5
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.0	-0.3	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	-0.4	-0.4	0.4
Intermittent access total infusions	0.1	0.2	0.5	-0.7	-0.0	-0.0
Intermittent access day 1 locomotion	0.7	0.8	1.4	0.2	0.9	-1.2
Intermittent access day 15 total locomotion	0.2	0.2	0.4	-0.7	0.3	-0.1
Intermittent access total locomotion	0.4	0.5	0.8	-0.0	0.8	-0.9
Intermittent access standard deviation	3.4	3.6	5.1	-2.3	-1.3	2.0
Left kidney weight	2.5	7.0	10.9	-3.3	-1.9	2.5
Right kidney weight	1.0	2.7	5.2	-2.3	-0.8	1.5
Cocaine induced anxiety	0.9	1.0	1.6	-0.0	-1.2	1.3
Post-drug Anxiety	0.5	0.5	0.9	0.9	-0.7	0.5
Baseline Anxiety	0.1	0.1	0.3	-0.2	0.5	-0.4
Tail length	0.4	1.4	3.0	1.7	-1.0	0.1
Length with tail	1.2	4.3	5.5	-1.5	-2.4	2.2
Length without tail	3.3	7.2	13.3	-3.6	-1.5	2.4
Times rat made contact with spout	0.4	0.4	1.1	1.1	-0.1	-0.3
Lifetime Intake	0.3	0.3	0.9	-1.0	0.1	0.0
Liver weight, left	2.2	3.5	4.2	-2.1	-1.5	2.0
Liver weight, right	0.8	1.3	2.1	-1.4	-0.5	1.2
Locomotor activity	0.0	0.0	0.1	0.1	-0.2	-0.2
Locomotor testing distance	0.1	0.1	0.3	0.1	-0.6	-0.3
Locomotor testing rearing	0.8	1.2	2.6	1.6	0.1	-1.0
Locomotion in novel chamber	1.0	1.2	3.1	1.8	-0.7	-0.2
Locomotion in novel chamber post-restriction	0.2	0.2	0.7	0.1	-0.8	0.2
Fecal boli incidents, locomotor time 1	0.7	0.7	1.6	0.1	0.7	-1.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.0	0.5	-0.4
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.0	0.6	-1.0	0.5
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.4	0.6	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.2	0.7	-0.4
Rest time, locomotor task time 1	0.7	0.8	1.4	-1.2	0.9	-0.1
Distance moved, locomotor task time 1	0.4	0.4	1.0	1.0	-0.5	0.1
Vertical activity count, locomotor time 1	1.2	1.2	3.2	1.8	0.2	-0.7
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.6	0.5	0.7	-0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.5	-0.2	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.5	-0.3	0.1
Rest time, locomotor task time 2	0.3	0.4	1.0	-1.0	-0.4	0.1
Distance moved, locomotor task time 2	0.1	0.2	0.4	0.3	0.6	0.0
Vertical activity count, locomotor time 2	0.2	0.2	0.4	0.2	0.6	-0.5
Light reinforcement 1	1.6	2.9	3.2	1.7	1.8	-1.6
Light reinforcement 2	0.1	0.2	0.2	0.5	0.5	0.1
Bone: marrow area	1.3	2.7	7.9	-0.4	-2.8	0.4
Bone: maximum diameter	5.4	10.0	12.8	-3.2	-3.6	2.6
Bone: maximum force	1.0	1.7	4.7	-2.2	-0.1	0.7
Bone: maximum moment	1.1	1.9	5.2	-2.3	-0.2	0.7
Mean time between licks in bursts	0.0	0.0	0.0	-0.0	0.0	0.0
Mean num. licks in bursts	0.4	0.5	0.7	0.7	0.6	-0.9
Cd content in liver	1.6	1.8	3.9	0.1	2.0	-1.2
Co content in liver	0.8	0.9	1.5	0.1	1.2	-1.1
Cu content in liver	0.1	0.1	0.2	-0.5	0.0	0.0
Fe content in liver	0.6	0.8	2.0	0.4	-1.4	0.4
K content in liver	0.2	0.2	0.3	0.5	-0.6	0.4
Mg content in liver	1.3	1.4	1.9	1.4	0.9	-1.1
Mn content in liver	0.8	0.9	1.6	-0.5	-1.0	1.3
Na content in liver	0.9	0.9	1.8	0.0	-1.3	1.0
Rb content in liver	2.4	2.9	3.4	1.8	1.7	-1.6
Se content in liver	0.8	1.0	2.4	1.5	-0.7	0.1
Sr content in liver	0.4	0.4	0.6	-0.8	0.7	0.1
Zn content in liver	1.2	1.3	2.4	-1.5	-0.8	1.0
Bone: minimum diameter	2.2	4.1	6.8	-1.8	-2.6	1.5
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.1	0.4	-0.1
Time in novel zone, hab. session 1	0.4	0.4	0.6	-0.2	-0.7	0.8
Total zone transitions, hab. session 1	1.5	2.2	2.5	1.6	1.2	-1.6
Total locomotion distance, hab. session 1	1.3	1.8	2.3	1.3	1.2	-1.5
Locomotion velocity, hab. session 1	1.7	2.5	3.3	1.3	1.5	-1.8
Time in familiar zone, hab. session 2	0.3	0.3	0.6	-0.1	0.8	-0.4
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.3	-0.8	0.7
Total zone transitions, hab. session 2	5.2	6.8	8.4	2.4	2.5	-2.9
Total locomotion distance, hab. session 2	5.2	6.8	8.3	2.0	2.9	-2.9
Locomotion velocity, hab. session 2	5.0	6.7	8.0	2.1	2.8	-2.8
Novel to familiar place preference ratio	2.2	2.3	3.3	1.2	1.4	-1.8
Novelty place preference	1.6	1.7	2.5	1.1	1.1	-1.6
Time in novel zone, NPP test	2.0	2.1	2.9	1.2	1.3	-1.7
Total zone transitions, NPP test	3.2	4.6	5.3	2.0	2.1	-2.3
Total locomotion distance, NPP test	6.5	8.9	11.0	2.2	3.3	-3.3
Locomotion velocity, NPP test	5.4	7.7	9.7	2.1	3.0	-3.1
Intraocular pressure	0.7	0.9	1.8	0.7	0.7	-1.4
Delta distance traveled before/after self-admin	3.4	3.7	5.4	1.4	1.9	-2.3
Delta ambulatory time before/after self-admin	3.6	3.9	5.8	1.6	1.9	-2.4
Parametrial fat weight	0.1	0.2	0.4	-0.6	0.3	-0.1
Pavlov. Cond. lever latency	0.6	0.8	1.0	1.0	0.7	-0.9
Pavlov. Cond. magazine entry latency	2.6	3.4	4.7	-1.2	-2.2	2.0
Pavlov. Cond. change in total contacts	0.4	0.4	0.7	-0.3	0.8	-0.7
Pavlov. Cond. index score	1.6	2.0	2.2	-1.3	-1.5	1.5
Pavlov. Cond. latency score	2.0	2.6	2.9	-1.5	-1.6	1.7
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.7	-0.1	0.3
Pavlov. Cond. magazine entry number	3.0	3.8	4.3	1.8	2.1	-2.0
Pavlov. Cond. intertrial magazine entries	1.9	2.3	3.3	1.8	1.2	-1.5
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.7	-1.0	-1.3	1.2
Pavlov. Cond. response bias	1.4	1.7	1.8	-1.3	-1.3	1.3
Pavlov. Cond. lever latency	1.1	1.4	2.3	-1.5	-0.1	1.4
Pavlov. Cond. magazine entry latency	0.6	0.7	1.4	0.0	0.9	-1.2
Pavlov. Cond. change in total contacts	0.9	1.3	2.3	1.0	0.7	-1.5
Pavlov. Cond. index score	0.7	0.9	1.7	1.0	0.2	-1.3
Pavlov. Cond. latency score	0.5	0.6	1.1	0.8	0.0	-1.1
Pavlov. Cond. lever contacts	1.2	1.6	3.3	1.8	-0.3	-1.2
Pavlov. Cond. magazine entry number	0.9	1.1	2.1	-0.5	-0.9	1.5
Pavlov. Cond. intertrial magazine entries	1.4	1.8	3.0	1.5	-1.7	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.9	1.1	0.3	-1.4
Pavlov. Cond. response bias	0.8	1.0	1.7	1.2	0.3	-1.3
Time in closed arm before self-admin	0.3	0.3	0.7	-0.5	0.9	-0.2
Time in closed arm after self-admin	1.6	1.7	2.8	-1.7	-0.9	1.2
Time in open arm before self-admin	0.3	0.3	0.5	-0.7	-0.1	0.6
Time in open arm after self-admin	0.5	0.6	0.9	1.0	0.6	-0.7
Bone: periosteal estimation	1.8	3.7	5.2	-2.2	-2.3	1.1
Bone: periosteal perimeter	4.6	7.7	9.7	-3.1	-2.8	2.4
Bone: post-yield work	0.6	0.8	1.4	0.5	0.8	-1.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.3	0.1	-0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.0	0.2	-0.4
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.5	-0.3	-0.7	0.6
Progressive ratio test 2 active lever presses	0.3	0.3	0.6	-0.1	0.6	-0.8
Progressive ratio test 2 breakpoint	0.3	0.4	0.6	-0.0	0.7	-0.8
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.3	0.3	-0.0
Incentive Sensitization - Responses	0.6	0.6	1.6	-1.3	-0.0	0.4
Incentive Sensitization - Breakpoint	0.7	0.7	1.8	-1.3	-0.2	0.6
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.6	-0.3	-0.2
Progressive ratio	0.2	0.3	0.3	-0.6	0.4	-0.6
Food seeking constrained by brief footshock	0.5	0.6	1.2	-1.1	-0.4	0.6
Seeking ratio, punishment vs. effort	0.5	0.6	1.0	0.0	-0.9	1.0
Retroperitoneal fat weight	0.3	0.9	1.5	-1.2	-0.7	0.8
Reaction time number correct	2.8	4.0	6.6	2.6	1.3	-1.9
Reaction time mean minus median	0.6	0.8	1.5	-1.2	-0.2	0.9
Reaction time mean minus median AUC	1.0	1.3	2.0	-1.0	-0.9	1.4
Reaction time num false alarms	0.1	0.1	0.3	0.2	0.1	-0.5
Reaction time num false alarms AUC	0.2	0.3	0.7	0.5	0.3	-0.8
Reaction time trials correct on left	2.8	4.0	6.6	2.6	1.3	-1.9
Reaction time trials on left	2.8	3.9	6.5	2.6	1.3	-1.9
Reaction time mean	0.0	0.0	0.1	-0.4	-0.0	0.2
Reaction time mean AUC	0.1	0.1	0.1	-0.3	0.3	-0.1
Median of all reaction times	0.0	0.0	0.0	-0.1	-0.1	-0.0
Reaction time omissions	0.6	0.8	0.9	-0.9	-0.9	1.0
Reaction time false alarm rate	0.2	0.3	0.7	-0.8	-0.4	0.3
Reaction time premature initiation rate	3.0	4.0	6.0	1.1	2.4	-2.2
Reaction time premature initiations	5.5	7.8	9.5	2.3	2.9	-3.1
Std. dev. reaction times	0.1	0.2	0.4	-0.7	0.3	0.2
Reaction time trials completed	2.8	3.9	6.5	2.6	1.3	-1.9
Reaction time trials AUC	3.3	4.8	7.6	2.8	1.5	-2.1
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.3	-0.3	0.1
Run reversals in cocaine runway, males	1.0	1.0	1.7	-1.1	1.3	-0.4
Latency to leave start box in cocaine runway	0.7	0.8	1.4	-0.0	1.2	-1.0
Latency to leave start box in cocaine runway, F	0.7	0.8	1.4	0.6	1.2	-0.8
Latency to leave start box in cocaine runway, M	1.2	1.1	2.2	0.1	1.1	-1.5
Std. dev. time between licks in bursts	1.2	1.5	2.9	1.7	0.4	-1.1
Total sessions with >9 infusions	1.0	1.1	3.0	-1.7	0.1	0.4
Short access day 1 total inactive lever presses	0.3	0.3	0.8	-0.9	-0.1	0.3
Short access day 10 total inactive lever presses	1.0	1.1	1.9	-0.6	-0.9	1.4
Short access day 1 total infusions	1.0	1.1	2.8	-1.7	-0.2	0.7
Short access day 10 total infusions	1.1	1.2	2.7	-1.6	-0.7	0.6
Short access total infusions	0.5	0.6	1.5	-1.2	0.5	-0.0
Short access day 1 locomotion	0.4	0.4	1.1	-1.0	0.1	0.3
Short access day 10 total locomotion	0.4	0.5	1.3	-1.1	0.1	0.3
Short access total locomotion	1.4	1.4	3.9	-2.0	0.5	0.4
One hour access (0.3 mA shock)	0.2	0.3	0.6	0.1	0.5	-0.8
Compulsive drug intake	1.1	1.1	2.4	0.1	1.6	-0.9
One hour access (shock baseline)	0.2	0.2	0.5	0.3	-0.7	0.1
Social response proportion	0.7	0.7	1.3	0.2	1.1	-0.9
Social responses	0.1	0.1	0.2	0.4	0.5	-0.1
Social time	0.7	0.9	1.8	0.1	1.3	-1.0
Soleus weight	0.8	2.2	4.6	0.6	2.1	-1.3
Bone: stiffness	1.1	1.7	3.7	-1.9	-0.5	1.1
Tibialis anterior weight	0.2	0.7	1.4	0.0	1.2	-0.8
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.6	0.7	0.8	-0.6
Time to tail flick, vehicle, after self-admin	1.6	1.7	4.3	-2.1	0.7	0.7
Time to tail flick, test, before self-admin	0.5	0.5	1.0	1.0	-0.6	-0.1
Time to tail flick, test, after self-admin	0.4	0.5	1.0	-1.0	-0.4	0.5
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.8	0.4	0.1
Delta time to tail flick, test, before/after SA	1.3	1.2	2.8	-1.7	0.1	0.8
Tibia length	10.8	30.3	37.7	-5.2	-5.1	6.1
Ambulatory time before self-admin	2.3	2.4	3.7	-0.8	-1.7	1.9
Ambulatory time after self-admin	0.4	0.4	0.6	0.6	0.5	-0.8
Bone: tissue strength	1.3	1.2	2.2	-0.1	1.5	-1.2
Total heroin consumption	1.9	2.2	3.7	-1.9	-1.3	1.1
Bone: trabecular number	0.5	0.8	2.0	1.4	-0.3	-0.4
Bone: trabecular spacing	0.3	0.3	0.7	-0.8	-0.4	0.4
Bone: trabecular thickness	0.5	0.6	1.0	1.0	0.2	-0.9
Bone: trabecular tissue density	0.2	0.3	0.5	-0.7	-0.4	0.5
Water consumed over 24 hours	0.4	0.4	1.3	1.1	-0.2	0.1
Number of responses in last shaping day	1.8	1.9	3.2	-1.8	-0.9	1.3