Timp4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Timp4	0.05	0.03	3.5e-05	0.04	0.04	0.04	0.04	8.9e-06	6.1e-05	3.6e-05	4.6e-05
2	PL	isoform ratio	NM_001109393.1	0.02	0.02	7.2e-03	0.01	0	-0	0	9.1e-03	1.3e-01	3.9e-01	1.3e-01
3	PL	isoform ratio	XM_039108336.1	0.02	0.02	9.7e-03	0.01	0	-0	0	1.2e-02	1.6e-01	4.6e-01	1.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.2	0.3	0.8	0.9	0.0	-0.0
Area under the delay curve	0.0	0.0	0.0	0.0	0.0	-0.0
BMI with tail	0.6	2.0	4.5	-2.1	0.9	-0.9
BMI without tail	0.4	0.8	1.0	-0.7	-1.0	1.0
Body weight	0.1	0.5	1.3	-1.2	0.2	-0.2
Weight adjusted by age	0.2	0.2	0.2	0.3	0.5	-0.5
Bone surface	0.4	0.7	2.1	1.5	-0.1	0.1
Bone volume	0.2	0.3	0.9	0.9	-0.3	0.3
Breakpoint value in progressive ratio session	1.3	1.4	4.1	-2.0	0.1	-0.1
Number of licking bursts	0.7	0.8	1.0	0.6	-1.0	1.0
Context. condit. distance diff. score	1.4	1.6	4.3	-2.1	0.6	-0.6
Locomotion velocity, session 1	0.3	0.4	0.5	0.0	-0.7	0.7
Locomotion distance, session 1	1.4	1.7	2.4	0.6	-1.6	1.6
Locomotion velocity, session 2	1.0	1.2	1.4	1.2	-1.0	1.0
Locomotion distance, session 2	3.3	4.6	6.3	1.1	-2.5	2.5
Locomotion velocity, session 3	0.5	0.5	1.4	1.2	0.3	-0.3
Locomotion distance, session 3	0.5	0.6	1.6	1.2	0.3	-0.3
Stereotopy head waving bouts, day 3	0.7	0.8	1.0	0.6	-1.0	1.0
Stereotopy head waving duration, day 3	0.8	0.9	1.4	0.2	-1.2	1.2
Locomotion velocity, session 7	0.4	0.4	1.3	1.1	0.0	-0.0
Locomotion distance, session 7	0.1	0.1	0.1	0.1	0.3	-0.3
Stereotopy head waving bouts, day 7	1.0	1.2	2.2	1.5	-0.8	0.8
Stereotopy head waving duration, day 7	1.5	1.8	2.3	1.5	-1.3	1.3
Locomotion velocity, session 8	0.6	0.8	1.1	-0.3	-1.0	1.0
Locomotion distance, session 8	1.3	1.8	2.0	-1.2	-1.4	1.4
Degree of sensitization distance	0.3	0.3	0.7	-0.8	-0.3	0.3
Degree of sensitization stereotypy	0.3	0.3	0.7	0.9	-0.3	0.3
Conditioned locomotion	1.4	1.7	2.4	-0.5	1.6	-1.6
Cocaine response after cond. corrected	6.4	7.2	8.8	2.0	-3.0	3.0
Cocaine response after cond. not corrected	6.9	7.6	7.7	2.7	-2.8	2.8
Cocaine response before conditioning	0.7	0.9	1.0	0.9	1.0	-1.0
Saline control response	1.7	2.2	4.1	2.0	1.1	-1.1
Bone: connectivity density	0.2	0.4	0.7	0.9	-0.5	0.5
Bone: cortical apparent density	0.2	0.3	0.3	0.6	-0.6	0.6
Bone: cortical area	0.1	0.2	0.3	-0.1	0.5	-0.5
Bone: cortical porosity	0.3	0.3	0.5	-0.0	-0.7	0.7
Bone: cortical porosity	0.2	0.2	0.3	-0.2	-0.5	0.5
Bone: cortical thickness	0.0	0.0	0.0	0.1	0.0	-0.0
Bone: cortical thickness	0.1	0.1	0.3	0.5	0.0	-0.0
Bone: cortical tissue density	0.3	0.4	0.4	0.5	-0.6	0.6
Condit. Reinf. active minus inactive responses	1.6	1.8	5.3	2.3	0.2	-0.2
Condit. Reinf. active-inactive response ratio	2.1	2.2	6.6	2.6	-0.2	0.2
Condit. Reinf. active responses	0.8	0.9	1.7	1.3	0.7	-0.7
Condit. Reinf. inactive responses	0.4	0.5	0.5	-0.7	0.7	-0.7
Incentive salience index mean	1.7	2.0	5.3	2.3	-0.6	0.6
Condit. Reinf. lever presses	1.5	2.0	2.1	1.3	-1.5	1.5
Condit. Reinf. active minus inactive responses	1.0	1.2	2.0	1.4	-0.9	0.9
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.1	0.5	-1.4	1.4
Condit. Reinf. active responses	0.4	0.5	1.5	1.2	-0.1	0.1
Condit. Reinf. inactive responses	1.4	1.7	2.2	0.8	1.5	-1.5
Condit. Reinf. lever presses	0.6	0.8	0.8	0.9	-0.9	0.9
Condit. Reinf. lever reinforcers received	0.7	1.0	2.8	1.7	-0.3	0.3
Conditioned reinforcement - actives	2.3	2.3	2.5	-1.4	1.6	-1.6
Conditioned reinforcement - inactives	0.2	0.2	0.6	0.8	0.2	-0.2
Conditioned locomotion	0.0	0.1	0.2	-0.4	0.0	-0.0
Patch foraging indifference point 0 sec	0.1	0.1	0.1	-0.3	0.3	-0.3
Patch foraging indifference point AUC	0.4	0.4	0.7	0.8	-0.5	0.5
Delay disc. indifference point, 0s delay	0.8	0.9	1.2	-0.4	1.1	-1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.1	-0.5	0.5
Delay disc. indifference point, 2s delay	0.7	0.8	0.8	-0.9	0.9	-0.9
Delay disc. indifference point, 24s delay	1.1	1.0	1.3	0.8	-1.1	1.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.1	0.3	-0.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	0.6	-0.3	0.3
Indifference point function ln k	0.5	0.7	1.9	-1.4	0.2	-0.2
Indifference point function log k	0.5	0.7	1.9	-1.4	0.2	-0.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	-0.7	0.3	-0.3
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	0.5	-0.7	0.7
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	0.7	0.5	-0.5
Patch foraging total patch changes 24 sec	1.1	1.4	2.0	-0.4	1.4	-1.4
Patch foraging total patch changes 6 sec	0.3	0.5	1.1	-1.0	0.4	-0.4
Patch foraging time to switch 0 sec	0.2	0.3	0.3	-0.4	0.6	-0.6
Patch foraging water rate 0 sec	0.5	0.9	1.3	0.2	-1.1	1.1
Patch foraging water rate 12 sec	0.2	0.3	0.3	-0.5	-0.5	0.5
Patch foraging water rate 18 sec	0.2	0.3	0.4	-0.6	0.5	-0.5
Patch foraging water rate 24 sec	0.4	0.6	0.9	0.0	-0.9	0.9
Patch foraging water rate 6 sec	1.1	1.5	2.3	0.2	-1.5	1.5
Seeking ratio, delayed vs. immediate footshock	1.7	1.9	2.2	-1.5	1.3	-1.3
Distance traveled before self-admin	1.5	1.6	2.8	1.7	-1.0	1.0
Distance traveled after self-admin	0.3	0.3	0.6	0.8	-0.4	0.4
Extensor digitorum longus weight	3.7	14.6	32.9	-5.7	2.3	-2.3
Bone: elastic displacement	1.6	1.8	2.6	0.1	1.6	-1.6
Bone: elastic work	0.2	0.2	0.3	-0.3	0.5	-0.5
Bone: endosteal estimation	0.1	0.2	0.2	-0.5	0.4	-0.4
Bone: endosteal perimeter	0.2	0.5	0.6	0.5	0.8	-0.8
Epididymis fat weight	0.1	0.3	0.6	0.8	0.4	-0.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.1	0.4	-0.4
Delta time in open arm before/after self-admin	0.2	0.2	0.4	-0.6	0.2	-0.2
Diff in mean of infusions in LGA sessions	0.4	0.4	0.6	-0.2	0.8	-0.8
Delay discount exponential model param	0.0	0.0	0.0	-0.1	0.1	-0.1
Extinction: sum of active levers before priming	0.1	0.1	0.1	0.2	0.4	-0.4
Active lever presses in extinction session 6	1.5	1.5	4.3	-2.1	0.3	-0.3
Bone: final force	0.3	0.4	0.9	-1.0	0.4	-0.4
Bone: final moment	0.4	0.6	1.0	-1.0	0.7	-0.7
Food consumed during 24 hour testing period	0.1	0.2	0.2	0.2	0.5	-0.5
Glucose	1.4	2.1	2.2	-1.5	1.4	-1.4
Heart weight	0.8	1.2	2.2	-1.5	0.8	-0.8
Delay discount hyperbolic model param	0.0	0.0	0.0	0.1	-0.0	0.0
Intermittent access intake day 1-15 change	1.8	1.8	3.2	-1.8	1.0	-1.0
Intermittent access intake escalation	1.8	1.7	2.3	-1.5	1.2	-1.2
Intermittent access intake escalation 2	1.7	1.7	4.1	-2.0	0.7	-0.7
Intermitt. access day 1 inactive lever presses	0.5	0.6	0.9	1.0	-0.6	0.6
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.9	1.0	-0.1	0.1
Intermitt. access escalation Index	0.0	0.0	0.0	-0.2	-0.1	0.1
Intermittent access day 1 total infusions	0.0	0.1	0.1	-0.2	0.2	-0.2
Intermittent access day 15 total infusions	2.5	2.8	3.1	-1.8	1.6	-1.6
Intermittent access terminal intake (last 3 days)	2.5	2.8	4.9	-2.2	1.3	-1.3
Intermittent access total infusions	1.2	1.3	1.4	-1.1	1.2	-1.2
Intermittent access day 1 locomotion	0.5	0.6	1.3	-1.1	0.5	-0.5
Intermittent access day 15 total locomotion	1.9	2.1	4.6	-2.1	0.9	-0.9
Intermittent access total locomotion	1.3	1.5	2.9	-1.7	0.9	-0.9
Intermittent access standard deviation	0.0	0.0	0.1	-0.0	0.2	-0.2
Left kidney weight	1.9	5.3	6.7	1.6	-2.6	2.6
Right kidney weight	2.3	6.6	7.0	2.4	-2.6	2.6
Cocaine induced anxiety	0.2	0.2	0.2	0.5	-0.5	0.5
Post-drug Anxiety	1.4	1.6	3.1	1.8	-0.9	0.9
Baseline Anxiety	1.1	1.1	2.1	1.5	-0.8	0.8
Tail length	1.1	3.3	4.0	1.4	-2.0	2.0
Length with tail	0.6	2.1	2.3	1.3	-1.5	1.5
Length without tail	0.1	0.3	0.7	0.9	-0.2	0.2
Times rat made contact with spout	0.6	0.7	1.1	0.3	-1.0	1.0
Lifetime Intake	0.9	1.1	1.3	-0.8	1.1	-1.1
Liver weight, left	0.3	0.4	1.2	1.1	0.2	-0.2
Liver weight, right	0.7	1.2	2.2	1.5	-0.8	0.8
Locomotor activity	1.0	1.5	3.3	1.8	-0.8	0.8
Locomotor testing distance	1.2	2.1	3.5	1.9	-1.2	1.2
Locomotor testing rearing	1.3	2.0	5.0	2.2	0.7	-0.7
Locomotion in novel chamber	0.9	1.1	1.6	-0.1	-1.3	1.3
Locomotion in novel chamber post-restriction	2.9	3.4	5.0	0.6	-2.2	2.2
Fecal boli incidents, locomotor time 1	0.9	0.9	1.3	0.6	-1.1	1.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.6	-0.0	0.8	-0.8
Time >=10cm from walls, locomotor time 1	1.6	1.6	2.3	1.5	-1.1	1.1
Bouts of movement, locomotor time 1	0.5	0.6	0.6	-0.7	0.8	-0.8
Total resting periods, locomotor time 1	1.1	1.2	1.3	-1.1	1.1	-1.1
Rest time, locomotor task time 1	2.2	2.4	6.7	-2.6	0.5	-0.5
Distance moved, locomotor task time 1	2.1	2.3	6.4	2.5	-0.5	0.5
Vertical activity count, locomotor time 1	0.7	0.7	1.8	1.3	0.4	-0.4
Time >=10cm from walls, locomotor time 2	1.2	1.3	1.7	1.3	-1.0	1.0
Bouts of movement, locomotor time 2	0.4	0.5	0.5	0.7	-0.7	0.7
Total resting periods, locomotor time 2	0.6	0.6	0.6	0.8	-0.8	0.8
Rest time, locomotor task time 2	0.4	0.5	1.0	-1.0	0.5	-0.5
Distance moved, locomotor task time 2	0.5	0.6	1.6	1.3	-0.2	0.2
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.0	-0.0	0.0
Light reinforcement 1	0.2	0.4	1.1	1.0	-0.3	0.3
Light reinforcement 2	0.0	0.0	0.0	0.1	0.1	-0.1
Bone: marrow area	0.1	0.2	0.2	-0.4	0.5	-0.5
Bone: maximum diameter	0.1	0.2	0.4	0.6	-0.2	0.2
Bone: maximum force	0.8	1.3	1.7	-1.3	1.1	-1.1
Bone: maximum moment	0.9	1.6	1.6	-1.2	1.3	-1.3
Mean time between licks in bursts	0.0	0.0	0.1	-0.4	-0.0	0.0
Mean num. licks in bursts	0.0	0.0	0.0	-0.2	0.1	-0.1
Cd content in liver	1.0	1.1	1.5	-1.2	-1.0	1.0
Co content in liver	1.2	1.4	3.1	-1.8	0.7	-0.7
Cu content in liver	0.9	1.1	1.5	-0.5	1.2	-1.2
Fe content in liver	0.2	0.2	0.5	-0.7	-0.2	0.2
K content in liver	1.4	1.4	2.5	1.6	-0.9	0.9
Mg content in liver	0.2	0.2	0.6	0.8	-0.2	0.2
Mn content in liver	0.2	0.3	0.6	0.8	-0.3	0.3
Na content in liver	0.7	0.7	2.1	1.4	-0.0	0.0
Rb content in liver	0.6	0.7	1.9	1.4	-0.3	0.3
Se content in liver	0.4	0.5	1.1	-1.1	0.4	-0.4
Sr content in liver	0.2	0.2	0.5	0.7	0.1	-0.1
Zn content in liver	1.3	1.4	2.1	0.2	-1.5	1.5
Bone: minimum diameter	1.2	2.2	2.6	-1.6	1.4	-1.4
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.4	-0.4	0.4
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.2	0.2	-0.2
Total zone transitions, hab. session 1	0.4	0.5	0.9	0.9	-0.6	0.6
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.3	0.0	-0.0
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.3	-0.1	0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.1	-0.2	-0.4	0.4
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	0.1	-0.1
Total zone transitions, hab. session 2	1.9	2.5	2.9	1.3	-1.7	1.7
Total locomotion distance, hab. session 2	2.1	2.8	3.0	1.6	-1.7	1.7
Locomotion velocity, hab. session 2	1.8	2.4	2.4	1.5	-1.5	1.5
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.2	0.4	-0.4
Novelty place preference	0.1	0.1	0.2	-0.4	0.2	-0.2
Time in novel zone, NPP test	0.2	0.2	0.3	-0.5	0.5	-0.5
Total zone transitions, NPP test	2.3	3.3	4.6	0.8	-2.1	2.1
Total locomotion distance, NPP test	0.8	1.1	1.7	0.1	-1.3	1.3
Locomotion velocity, NPP test	1.4	2.0	2.9	0.4	-1.7	1.7
Intraocular pressure	0.2	0.3	0.5	0.1	-0.7	0.7
Delta distance traveled before/after self-admin	2.3	2.4	3.2	-1.0	1.8	-1.8
Delta ambulatory time before/after self-admin	1.5	1.6	1.9	-1.0	1.4	-1.4
Parametrial fat weight	0.1	0.2	0.3	-0.0	0.5	-0.5
Pavlov. Cond. lever latency	0.1	0.2	0.4	-0.7	-0.1	0.1
Pavlov. Cond. magazine entry latency	1.4	1.9	2.0	1.2	-1.4	1.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.2	0.5	-0.5	0.5
Pavlov. Cond. index score	0.3	0.4	0.7	0.8	-0.5	0.5
Pavlov. Cond. latency score	0.4	0.5	0.7	0.8	-0.6	0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.5	-0.0	0.0
Pavlov. Cond. magazine entry number	1.0	1.2	1.7	-1.3	1.0	-1.0
Pavlov. Cond. intertrial magazine entries	1.4	1.7	2.5	-0.3	1.6	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	0.9	-0.7	0.7
Pavlov. Cond. response bias	1.0	1.2	1.4	1.2	-1.0	1.0
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.5	0.4	-0.4
Pavlov. Cond. magazine entry latency	0.7	0.8	1.0	0.5	-1.0	1.0
Pavlov. Cond. change in total contacts	1.9	2.7	3.1	1.4	-1.8	1.8
Pavlov. Cond. index score	0.7	0.9	1.0	0.8	-1.0	1.0
Pavlov. Cond. latency score	0.9	1.1	1.5	0.6	-1.2	1.2
Pavlov. Cond. lever contacts	0.5	0.6	0.8	0.5	-0.9	0.9
Pavlov. Cond. magazine entry number	1.7	2.1	2.5	-1.2	1.6	-1.6
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.3	0.9	-1.1	1.1
Pavlov. Cond. response bias	0.6	0.8	1.0	0.6	-1.0	1.0
Time in closed arm before self-admin	0.1	0.1	0.1	-0.2	-0.4	0.4
Time in closed arm after self-admin	0.2	0.2	0.5	-0.7	0.1	-0.1
Time in open arm before self-admin	0.0	0.0	0.0	0.2	-0.1	0.1
Time in open arm after self-admin	0.1	0.1	0.2	-0.1	0.4	-0.4
Bone: periosteal estimation	0.1	0.3	0.3	-0.3	0.6	-0.6
Bone: periosteal perimeter	0.2	0.4	0.8	0.9	0.4	-0.4
Bone: post-yield work	0.0	0.0	0.1	0.3	0.1	-0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.2	0.2	-0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.0	0.2	-0.2
Progressive ratio test 1 inactive lever presses	0.8	0.8	0.8	0.9	-0.9	0.9
Progressive ratio test 2 active lever presses	2.6	2.8	3.3	-1.4	1.8	-1.8
Progressive ratio test 2 breakpoint	2.5	2.8	3.2	-1.4	1.8	-1.8
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	0.2	0.2	-0.2
Incentive Sensitization - Responses	1.9	1.9	2.0	-1.3	1.4	-1.4
Incentive Sensitization - Breakpoint	2.0	2.1	2.3	-1.5	1.4	-1.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.4	0.2	-0.2
Progressive ratio	0.4	0.4	0.8	-0.9	0.5	-0.5
Food seeking constrained by brief footshock	3.1	3.8	4.6	-1.5	2.2	-2.2
Seeking ratio, punishment vs. effort	0.2	0.2	0.3	-0.1	0.6	-0.6
Retroperitoneal fat weight	0.1	0.4	1.1	1.0	-0.3	0.3
Reaction time number correct	1.3	1.8	2.1	-1.2	1.4	-1.4
Reaction time mean minus median	0.7	0.9	1.3	0.3	1.1	-1.1
Reaction time mean minus median AUC	0.5	0.7	1.0	0.2	1.0	-1.0
Reaction time num false alarms	0.7	0.9	2.7	-1.7	-0.2	0.2
Reaction time num false alarms AUC	0.5	0.6	1.2	-1.1	-0.6	0.6
Reaction time trials correct on left	1.3	1.8	2.1	-1.2	1.4	-1.4
Reaction time trials on left	1.1	1.6	1.8	-1.1	1.3	-1.3
Reaction time mean	0.6	0.9	2.1	1.4	0.5	-0.5
Reaction time mean AUC	0.6	0.8	1.8	1.3	0.5	-0.5
Median of all reaction times	0.6	0.8	2.2	1.5	0.4	-0.4
Reaction time omissions	1.2	1.7	2.0	1.0	-1.4	1.4
Reaction time false alarm rate	0.8	1.2	1.7	-0.2	-1.3	1.3
Reaction time premature initiation rate	0.3	0.4	0.6	0.8	-0.6	0.6
Reaction time premature initiations	0.0	0.0	0.1	0.3	0.1	-0.1
Std. dev. reaction times	0.3	0.4	1.0	1.0	-0.3	0.3
Reaction time trials completed	1.1	1.6	1.8	-1.1	1.3	-1.3
Reaction time trials AUC	1.1	1.6	1.7	-1.2	1.3	-1.3
Run reversals in cocaine runway, females	2.6	2.5	3.4	0.9	-1.8	1.8
Run reversals in cocaine runway, males	1.2	1.2	1.6	0.6	-1.3	1.3
Latency to leave start box in cocaine runway	1.1	1.2	3.3	1.8	-0.4	0.4
Latency to leave start box in cocaine runway, F	0.4	0.5	1.3	1.2	-0.1	0.1
Latency to leave start box in cocaine runway, M	0.6	0.5	1.6	1.2	0.2	-0.2
Std. dev. time between licks in bursts	0.8	0.9	1.4	0.2	-1.2	1.2
Total sessions with >9 infusions	1.1	1.2	2.9	1.7	0.6	-0.6
Short access day 1 total inactive lever presses	0.7	0.8	1.5	1.2	-0.7	0.7
Short access day 10 total inactive lever presses	1.7	1.9	2.0	1.3	-1.4	1.4
Short access day 1 total infusions	0.1	0.1	0.2	0.5	0.2	-0.2
Short access day 10 total infusions	0.6	0.6	0.7	-0.7	0.8	-0.8
Short access total infusions	0.2	0.2	0.3	0.2	0.6	-0.6
Short access day 1 locomotion	0.7	0.7	1.8	-1.3	0.4	-0.4
Short access day 10 total locomotion	0.1	0.1	0.1	-0.3	0.2	-0.2
Short access total locomotion	0.6	0.6	0.9	-0.1	1.0	-1.0
One hour access (0.3 mA shock)	4.3	5.1	6.5	-1.5	2.5	-2.5
Compulsive drug intake	0.6	0.6	0.7	0.6	0.8	-0.8
One hour access (shock baseline)	2.5	2.9	3.6	-1.9	1.6	-1.6
Social response proportion	0.6	0.7	1.9	1.4	0.2	-0.2
Social responses	0.9	1.1	1.9	1.4	-0.9	0.9
Social time	0.4	0.5	1.1	1.0	-0.4	0.4
Soleus weight	0.8	2.4	4.2	-2.0	1.2	-1.2
Bone: stiffness	0.3	0.4	1.1	-1.1	0.2	-0.2
Tibialis anterior weight	2.1	7.2	10.3	-1.0	3.2	-3.2
Time to tail flick, vehicle, before self-admin	1.4	1.4	3.7	1.9	-0.5	0.5
Time to tail flick, vehicle, after self-admin	1.9	2.0	2.8	-0.7	-1.7	1.7
Time to tail flick, test, before self-admin	0.2	0.2	0.2	0.4	-0.4	0.4
Time to tail flick, test, after self-admin	0.6	0.6	0.9	0.3	-1.0	1.0
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.7	-0.5	-1.3	1.3
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	0.7	-0.5	0.5
Tibia length	0.6	1.7	3.8	1.9	-0.8	0.8
Ambulatory time before self-admin	1.1	1.1	1.3	1.1	-1.0	1.0
Ambulatory time after self-admin	0.1	0.1	0.1	-0.2	0.3	-0.3
Bone: tissue strength	0.5	0.5	1.3	1.1	0.4	-0.4
Total heroin consumption	0.1	0.1	0.1	-0.4	-0.4	0.4
Bone: trabecular number	0.5	0.8	2.2	1.5	0.2	-0.2
Bone: trabecular spacing	0.7	0.9	1.4	-1.2	0.8	-0.8
Bone: trabecular thickness	0.2	0.3	0.8	0.9	-0.2	0.2
Bone: trabecular tissue density	0.9	1.2	2.7	1.7	0.7	-0.7
Water consumed over 24 hours	0.0	0.0	0.0	-0.2	-0.0	0.0
Number of responses in last shaping day	2.5	2.6	3.2	-1.8	1.5	-1.5