Timm44

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose isoform ratio NM_017267.2 0.11 0.06 3.9e-04 0.02 0.03 0.01 -0 2.0e-03 5.4e-04 5.6e-02 3.9e-01
2 Adipose isoform ratio XM_039089299.1 0.1 0.06 4.2e-04 0.02 0.03 0.01 -0 2.0e-03 7.2e-04 5.1e-02 8.9e-01
3 Liver gene expression Timm44 0.16 0.12 1.1e-04 0.04 0.03 0.03 0.04 3.4e-05 2.6e-04 1.4e-04 4.9e-05
4 pVTA intron excision ratio chr12_2623179_2627589 0.08 0.05 3.0e-03 0.04 0.03 0.03 0.03 8.7e-03 1.3e-02 2.5e-02 1.7e-02
5 pVTA intron excision ratio chr12_2627687_2629221 0.08 0.05 5.5e-03 0.04 0.03 0.03 0.02 1.2e-02 3.0e-02 1.4e-02 3.1e-02
6 PL gene expression Timm44 0.04 0.04 8.5e-04 0.02 0.03 0.03 0.03 9.5e-04 3.7e-04 5.7e-04 1.8e-04
7 Brain gene expression Timm44 0.05 0.03 1.2e-06 0.05 0.07 0.07 0.06 2.6e-05 7.5e-07 6.2e-07 3.3e-06
8 RMTg gene expression Timm44 0.14 0.09 3.1e-03 0.06 0.07 0.05 0.07 8.4e-03 5.1e-03 1.5e-02 7.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density4.57.511.7-2.82.7-3.43.4-2.92.6-2.01.1
Area under the delay curve0.30.31.00.7-0.60.1-0.1-0.20.5-0.71.0
BMI with tail1.96.210.9-1.61.6-3.33.3-2.23.1-2.41.6
BMI without tail1.83.76.2-2.01.9-2.52.5-2.11.8-1.30.4
Body weight6.828.548.3-5.95.6-7.06.9-5.74.8-3.20.7
Weight adjusted by age0.30.30.7-0.90.8-0.50.5-0.10.10.0-0.6
Bone surface4.68.013.5-2.92.7-3.73.7-2.82.9-2.01.1
Bone volume4.47.412.4-2.42.3-3.53.5-2.63.0-2.31.6
Breakpoint value in progressive ratio session2.52.73.3-1.31.4-1.81.8-1.51.8-1.81.7
Number of licking bursts5.05.910.50.9-0.92.4-2.42.2-3.03.1-3.2
Context. condit. distance diff. score7.59.011.7-3.13.0-3.43.4-3.32.9-2.72.1
Locomotion velocity, session 10.00.10.20.1-0.00.1-0.1-0.20.2-0.30.4
Locomotion distance, session 10.30.40.90.9-0.80.9-0.90.4-0.40.10.1
Locomotion velocity, session 20.60.71.10.8-0.81.0-1.00.6-1.00.7-0.8
Locomotion distance, session 20.60.92.10.6-0.51.5-1.40.5-1.20.7-0.5
Locomotion velocity, session 31.41.72.3-1.01.0-1.41.4-1.51.4-1.41.1
Locomotion distance, session 30.10.20.3-0.50.5-0.30.2-0.60.2-0.40.3
Stereotopy head waving bouts, day 31.01.22.2-1.51.4-1.21.1-1.30.6-0.5-0.2
Stereotopy head waving duration, day 30.00.00.10.3-0.3-0.00.0-0.00.10.0-0.1
Locomotion velocity, session 70.20.20.50.7-0.70.4-0.50.3-0.20.10.1
Locomotion distance, session 70.00.10.2-0.20.3-0.10.1-0.30.2-0.30.4
Stereotopy head waving bouts, day 70.10.10.20.2-0.10.3-0.3-0.30.0-0.40.5
Stereotopy head waving duration, day 70.20.20.50.6-0.60.7-0.70.3-0.40.1-0.0
Locomotion velocity, session 80.00.00.2-0.0-0.0-0.10.1-0.50.1-0.1-0.1
Locomotion distance, session 81.42.03.1-1.51.4-1.61.6-1.81.3-1.20.8
Degree of sensitization distance1.01.01.51.1-1.11.0-1.11.2-0.80.8-0.4
Degree of sensitization stereotypy0.10.10.30.3-0.20.1-0.2-0.20.1-0.40.5
Conditioned locomotion0.60.81.1-0.40.4-0.90.9-1.01.0-1.01.0
Cocaine response after cond. corrected0.40.41.51.2-1.2-0.10.10.70.40.2-0.2
Cocaine response after cond. not corrected0.80.92.30.3-0.3-1.21.2-0.51.5-1.01.0
Cocaine response before conditioning4.65.67.2-2.12.2-2.32.3-2.72.3-2.52.5
Saline control response1.11.44.0-2.02.00.1-0.1-0.8-0.90.7-1.3
Bone: connectivity density4.87.511.9-3.23.1-3.43.4-2.82.4-1.70.7
Bone: cortical apparent density0.20.20.90.9-1.00.1-0.10.00.10.00.2
Bone: cortical area2.64.06.0-1.81.8-2.42.4-2.12.1-1.71.2
Bone: cortical porosity0.00.10.1-0.30.30.1-0.10.1-0.20.1-0.3
Bone: cortical porosity0.10.10.2-0.40.50.2-0.20.1-0.0-0.20.2
Bone: cortical thickness1.52.54.3-1.41.3-2.12.1-1.71.7-1.30.9
Bone: cortical thickness0.50.61.5-1.21.2-0.70.7-0.60.3-0.2-0.1
Bone: cortical tissue density0.20.31.11.0-1.00.2-0.20.10.00.10.1
Condit. Reinf. active minus inactive responses0.20.20.70.4-0.4-0.20.20.40.6-0.50.8
Condit. Reinf. active-inactive response ratio0.40.51.00.00.0-0.70.8-0.11.0-0.81.0
Condit. Reinf. active responses0.20.31.0-0.20.3-0.30.3-0.00.6-0.81.0
Condit. Reinf. inactive responses0.10.10.4-0.30.40.3-0.4-0.3-0.1-0.50.6
Incentive salience index mean0.40.51.7-0.20.3-0.50.5-0.10.8-1.01.3
Condit. Reinf. lever presses0.81.12.5-0.80.8-0.90.9-0.71.1-1.31.6
Condit. Reinf. active minus inactive responses0.40.51.2-1.11.1-0.70.7-0.50.3-0.10.0
Condit. Reinf. active-inactive response ratio0.10.10.2-0.30.30.2-0.20.2-0.40.5-0.4
Condit. Reinf. active responses1.72.33.4-1.91.8-1.71.7-1.51.3-1.21.0
Condit. Reinf. inactive responses1.82.22.6-1.61.6-1.61.6-1.61.3-1.41.2
Condit. Reinf. lever presses2.33.23.7-1.61.6-1.91.9-1.81.8-1.91.7
Condit. Reinf. lever reinforcers received1.21.72.6-1.61.6-1.41.4-1.31.1-1.00.9
Conditioned reinforcement - actives1.01.02.8-1.71.6-0.70.7-0.8-0.30.3-0.9
Conditioned reinforcement - inactives0.60.71.30.0-0.00.8-0.80.5-1.11.0-1.2
Conditioned locomotion1.92.35.3-2.32.3-1.31.3-1.70.6-0.70.2
Patch foraging indifference point 0 sec0.00.10.3-0.30.30.1-0.1-0.5-0.20.0-0.0
Patch foraging indifference point AUC0.20.20.5-0.70.7-0.30.3-0.4-0.20.3-0.4
Delay disc. indifference point, 0s delay0.30.30.90.9-1.0-0.30.3-0.00.6-0.20.2
Delay disc. indifference point, 16s delay0.20.20.50.7-0.70.5-0.5-0.1-0.1-0.10.3
Delay disc. indifference point, 2s delay1.41.54.60.4-0.4-0.80.8-0.61.6-1.72.1
Delay disc. indifference point, 24s delay0.80.81.31.2-1.11.1-1.10.7-0.80.6-0.2
Delay disc. indifference point, 4s delay0.70.72.40.4-0.4-0.40.4-0.51.1-1.21.6
Delay disc. indifference point, 8s delay0.10.10.50.2-0.10.2-0.2-0.20.2-0.60.7
Indifference point function ln k0.20.30.8-0.90.90.3-0.30.1-0.40.3-0.5
Indifference point function log k0.20.30.8-0.90.90.3-0.30.1-0.40.3-0.5
Patch foraging total patch changes 0 sec0.10.10.3-0.40.40.1-0.1-0.6-0.30.00.0
Patch foraging total patch changes 12 sec0.20.20.8-0.40.4-0.50.5-0.90.4-0.30.2
Patch foraging total patch changes 18 sec0.20.20.6-0.0-0.00.4-0.40.2-0.70.8-0.6
Patch foraging total patch changes 24 sec0.40.41.3-0.90.9-0.10.1-1.1-0.1-0.50.6
Patch foraging total patch changes 6 sec0.30.41.2-0.90.9-0.50.5-1.10.2-0.30.2
Patch foraging time to switch 0 sec1.52.37.92.8-2.80.8-0.81.30.20.10.4
Patch foraging water rate 0 sec1.93.09.6-3.13.1-1.11.1-1.50.0-0.3-0.5
Patch foraging water rate 12 sec0.61.03.3-1.81.8-0.20.2-1.0-0.1-0.40.2
Patch foraging water rate 18 sec0.60.82.3-1.51.5-0.10.1-0.90.1-0.80.6
Patch foraging water rate 24 sec1.72.47.5-2.72.7-1.01.0-1.40.3-0.6-0.1
Patch foraging water rate 6 sec1.82.75.2-2.22.3-1.41.4-1.61.1-1.51.1
Seeking ratio, delayed vs. immediate footshock5.15.97.42.5-2.42.7-2.72.6-2.42.3-1.6
Distance traveled before self-admin0.10.10.50.2-0.20.2-0.2-0.20.1-0.40.7
Distance traveled after self-admin0.10.10.2-0.30.30.0-0.0-0.4-0.0-0.30.4
Extensor digitorum longus weight4.316.825.0-5.04.9-4.74.7-4.23.4-3.01.7
Bone: elastic displacement0.20.20.5-0.70.7-0.30.3-0.6-0.0-0.1-0.4
Bone: elastic work2.43.15.8-2.42.4-1.81.8-2.21.0-1.00.1
Bone: endosteal estimation0.30.72.0-1.41.4-0.50.5-0.8-0.10.1-0.6
Bone: endosteal perimeter1.73.66.2-2.52.5-1.91.9-2.01.4-1.40.9
Epididymis fat weight1.74.04.9-1.41.5-2.12.1-2.22.2-2.22.2
Delta time in closed arm before/after self-admin0.20.20.7-0.80.8-0.20.2-0.1-0.10.0-0.0
Delta time in open arm before/after self-admin0.70.72.01.4-1.40.5-0.50.50.3-0.40.9
Diff in mean of infusions in LGA sessions1.31.51.8-1.31.3-1.11.1-1.41.1-1.21.1
Delay discount exponential model param0.40.41.5-0.40.40.0-0.00.4-0.60.9-1.2
Extinction: sum of active levers before priming0.40.41.40.5-0.5-0.10.1-0.10.6-0.81.2
Active lever presses in extinction session 60.50.50.8-0.50.5-0.90.9-0.80.8-0.80.6
Bone: final force0.61.02.0-1.41.3-1.11.1-1.10.4-0.1-0.6
Bone: final moment0.40.71.5-1.21.1-0.90.9-0.90.20.1-0.7
Food consumed during 24 hour testing period0.50.61.2-0.30.30.6-0.61.0-0.91.0-1.1
Glucose0.40.61.91.4-1.40.6-0.50.5-0.20.3-0.2
Heart weight0.91.23.1-0.80.81.3-1.40.2-1.81.0-0.9
Delay discount hyperbolic model param0.40.41.5-0.50.5-0.00.00.2-0.60.9-1.2
Intermittent access intake day 1-15 change0.40.41.5-0.40.40.3-0.30.2-0.80.7-1.2
Intermittent access intake escalation0.30.30.8-0.90.9-0.00.0-0.3-0.40.3-0.8
Intermittent access intake escalation 20.10.10.3-0.30.30.4-0.40.1-0.60.2-0.4
Intermitt. access day 1 inactive lever presses0.80.92.0-0.20.21.0-1.00.8-1.41.2-1.2
Intermitt. access day 15 inactive lever presses0.60.61.51.2-1.20.4-0.41.0-0.20.5-0.6
Intermitt. access escalation Index0.40.40.8-0.80.9-0.00.0-0.70.2-0.50.7
Intermittent access day 1 total infusions0.20.20.70.2-0.10.6-0.6-0.3-0.1-0.50.8
Intermittent access day 15 total infusions0.20.20.4-0.60.60.3-0.3-0.6-0.3-0.30.1
Intermittent access terminal intake (last 3 days)0.10.10.40.3-0.30.6-0.60.1-0.4-0.10.1
Intermittent access total infusions0.10.10.50.1-0.10.3-0.3-0.30.1-0.60.7
Intermittent access day 1 locomotion1.11.13.9-0.30.4-0.30.3-1.21.0-1.62.0
Intermittent access day 15 total locomotion1.61.73.3-1.71.8-0.40.4-1.70.5-1.41.3
Intermittent access total locomotion0.80.92.7-0.80.9-0.10.1-1.10.5-1.41.7
Intermittent access standard deviation0.30.30.80.5-0.50.3-0.30.7-0.40.6-0.9
Left kidney weight3.610.321.5-4.64.5-3.53.5-3.41.7-1.0-0.7
Right kidney weight2.77.714.8-3.93.7-3.23.2-2.91.6-0.8-0.7
Cocaine induced anxiety1.92.24.1-0.80.9-1.41.4-1.31.7-2.02.0
Post-drug Anxiety0.80.92.41.2-1.20.1-0.10.30.8-1.11.6
Baseline Anxiety2.93.17.82.8-2.81.6-1.61.7-0.70.9-0.2
Tail length3.711.120.0-4.54.3-3.83.7-4.02.1-1.4-0.2
Length with tail6.624.040.5-6.46.1-5.95.8-5.63.3-2.0-0.3
Length without tail5.512.019.7-3.73.5-4.44.4-3.83.1-2.20.8
Times rat made contact with spout0.40.51.2-1.11.10.0-0.00.1-0.40.6-0.9
Lifetime Intake0.20.20.60.8-0.80.5-0.50.2-0.0-0.20.5
Liver weight, left0.20.20.5-0.70.6-0.30.3-0.5-0.20.4-0.7
Liver weight, right2.74.57.8-2.82.7-2.42.4-2.31.6-1.20.5
Locomotor activity1.62.66.8-2.62.6-1.31.3-1.70.6-0.70.0
Locomotor testing distance0.50.92.8-1.71.6-0.60.6-0.80.1-0.1-0.4
Locomotor testing rearing0.10.20.5-0.70.7-0.30.3-0.20.2-0.20.0
Locomotion in novel chamber0.50.61.3-0.80.90.7-0.70.1-1.10.6-0.7
Locomotion in novel chamber post-restriction1.61.95.8-2.42.4-0.80.8-1.40.1-0.5-0.0
Fecal boli incidents, locomotor time 11.61.84.2-2.12.0-1.21.2-1.30.6-0.70.3
Change in fecal boli incidents, locomotor task1.51.43.01.7-1.71.1-1.11.0-0.80.8-0.7
Time >=10cm from walls, locomotor time 10.80.82.20.2-0.2-0.60.6-0.51.2-1.21.5
Bouts of movement, locomotor time 10.50.61.8-1.31.3-0.50.5-0.80.0-0.1-0.3
Total resting periods, locomotor time 10.60.71.9-1.41.4-0.60.6-0.80.2-0.2-0.1
Rest time, locomotor task time 11.31.42.2-1.41.3-1.51.5-1.21.1-0.80.4
Distance moved, locomotor task time 10.40.50.80.6-0.60.9-0.90.6-0.70.5-0.2
Vertical activity count, locomotor time 10.20.20.40.1-0.10.5-0.50.3-0.70.4-0.3
Time >=10cm from walls, locomotor time 22.83.04.7-1.01.0-2.02.0-1.92.2-1.81.5
Bouts of movement, locomotor time 22.22.33.5-1.91.9-1.71.7-1.41.4-1.20.8
Total resting periods, locomotor time 21.82.02.8-1.71.7-1.61.6-1.21.3-1.10.7
Rest time, locomotor task time 20.60.70.9-0.70.8-0.90.9-0.91.0-0.90.8
Distance moved, locomotor task time 21.72.02.81.0-1.01.5-1.51.2-1.71.7-1.6
Vertical activity count, locomotor time 20.80.82.5-0.30.30.6-0.60.0-1.31.2-1.6
Light reinforcement 10.20.30.80.9-0.80.5-0.5-0.0-0.1-0.30.8
Light reinforcement 21.11.42.01.1-1.11.4-1.41.0-1.41.0-0.9
Bone: marrow area0.30.72.0-1.41.4-0.40.4-0.7-0.20.2-0.7
Bone: maximum diameter1.42.63.6-1.81.8-1.91.9-1.71.5-1.20.6
Bone: maximum force1.32.24.0-2.01.9-1.61.6-1.70.9-0.7-0.0
Bone: maximum moment0.91.63.1-1.81.7-1.31.3-1.50.7-0.5-0.2
Mean time between licks in bursts0.30.50.91.0-0.90.8-0.80.5-0.40.10.2
Mean num. licks in bursts2.32.83.9-1.21.2-1.71.7-1.51.9-2.01.8
Cd content in liver1.41.63.30.5-0.41.8-1.81.0-1.71.1-0.7
Co content in liver1.01.12.1-0.10.11.1-1.11.1-1.41.3-1.4
Cu content in liver0.20.30.5-0.70.7-0.40.4-0.50.3-0.50.6
Fe content in liver6.88.19.2-3.03.0-3.03.0-2.92.7-2.72.3
K content in liver0.40.40.6-0.20.2-0.70.7-0.20.8-0.70.8
Mg content in liver0.00.00.0-0.20.2-0.10.10.1-0.10.1-0.2
Mn content in liver1.71.93.01.3-1.31.4-1.41.7-1.31.4-1.2
Na content in liver0.50.60.9-0.50.5-0.90.9-0.90.8-0.70.5
Rb content in liver0.50.62.10.9-0.8-0.10.10.30.7-0.81.5
Se content in liver5.97.210.5-1.61.6-3.13.1-2.33.2-3.02.9
Sr content in liver1.31.22.50.8-0.91.0-1.00.8-1.21.4-1.6
Zn content in liver0.30.30.7-0.80.8-0.60.6-0.2-0.10.2-0.7
Bone: minimum diameter0.00.00.1-0.00.00.2-0.20.3-0.20.2-0.3
Time in familiar zone, hab. session 10.40.40.70.8-0.90.4-0.50.8-0.30.6-0.5
Time in novel zone, hab. session 10.20.20.4-0.50.5-0.40.4-0.60.2-0.30.2
Total zone transitions, hab. session 10.30.40.60.8-0.70.7-0.70.5-0.3-0.10.7
Total locomotion distance, hab. session 10.50.72.50.5-0.4-0.50.4-0.60.9-1.11.6
Locomotion velocity, hab. session 10.40.62.50.8-0.7-0.10.0-0.30.6-1.01.6
Time in familiar zone, hab. session 20.10.10.20.4-0.4-0.30.30.10.4-0.10.2
Time in novel zone, hab. session 20.10.10.2-0.10.10.4-0.4-0.2-0.3-0.00.0
Total zone transitions, hab. session 20.60.81.40.3-0.31.0-1.10.6-1.21.0-1.1
Total locomotion distance, hab. session 20.20.20.50.5-0.40.7-0.70.2-0.60.2-0.1
Locomotion velocity, hab. session 20.30.40.80.6-0.60.8-0.90.4-0.80.5-0.3
Novel to familiar place preference ratio0.60.61.00.5-0.50.9-0.80.8-0.90.9-1.0
Novelty place preference0.80.81.10.7-0.71.0-0.90.8-0.90.9-0.9
Time in novel zone, NPP test0.50.50.70.5-0.50.8-0.70.6-0.80.8-0.9
Total zone transitions, NPP test0.00.10.2-0.40.40.00.0-0.4-0.1-0.10.1
Total locomotion distance, NPP test1.31.82.8-0.80.8-1.21.2-1.61.4-1.61.7
Locomotion velocity, NPP test1.01.52.1-1.01.1-1.01.0-1.41.1-1.41.4
Intraocular pressure2.43.35.0-2.22.2-1.91.9-1.91.4-1.61.0
Delta distance traveled before/after self-admin0.20.30.6-0.10.00.5-0.50.3-0.70.6-0.7
Delta ambulatory time before/after self-admin0.10.10.20.1-0.20.4-0.40.3-0.40.4-0.4
Parametrial fat weight0.71.42.01.3-1.31.0-1.01.0-1.11.3-1.4
Pavlov. Cond. lever latency0.40.51.1-1.01.0-0.50.5-0.6-0.10.4-1.0
Pavlov. Cond. magazine entry latency0.20.30.7-0.90.9-0.40.5-0.60.3-0.40.2
Pavlov. Cond. change in total contacts0.30.31.00.5-0.5-0.20.30.10.6-0.71.0
Pavlov. Cond. index score0.40.51.0-0.40.4-0.60.6-0.50.8-0.91.0
Pavlov. Cond. latency score0.30.41.2-0.20.2-0.50.5-0.40.7-0.91.1
Pavlov. Cond. lever contacts0.30.31.20.7-0.60.2-0.20.20.3-0.61.1
Pavlov. Cond. magazine entry number1.21.52.61.6-1.61.1-1.21.2-1.01.1-0.9
Pavlov. Cond. intertrial magazine entries0.60.71.60.6-0.61.2-1.30.8-1.00.6-0.3
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.30.3-0.60.6-0.50.8-0.90.9
Pavlov. Cond. response bias0.70.91.2-0.91.0-0.90.9-0.80.9-1.11.0
Pavlov. Cond. lever latency1.01.32.10.9-0.91.0-1.01.1-1.21.4-1.5
Pavlov. Cond. magazine entry latency0.50.62.20.4-0.4-0.40.4-0.20.9-1.11.5
Pavlov. Cond. change in total contacts0.30.40.7-0.60.6-0.50.5-0.60.5-0.80.8
Pavlov. Cond. index score0.60.82.3-0.30.4-0.60.6-0.70.9-1.31.5
Pavlov. Cond. latency score0.70.82.4-0.20.3-0.60.6-0.71.0-1.31.6
Pavlov. Cond. lever contacts1.82.44.1-1.01.0-1.51.5-1.51.7-2.02.0
Pavlov. Cond. magazine entry number0.20.31.3-0.50.4-0.10.1-0.1-0.40.7-1.1
Pavlov. Cond. intertrial magazine entries0.30.40.9-1.00.9-0.10.1-0.2-0.40.5-0.8
Pavlov. Cond. lever-magazine prob. diff.0.50.62.0-0.20.3-0.40.4-0.50.8-1.11.4
Pavlov. Cond. response bias1.82.45.4-0.80.9-1.41.4-1.41.7-2.02.3
Time in closed arm before self-admin0.20.30.9-0.50.40.1-0.1-0.2-0.60.5-1.0
Time in closed arm after self-admin0.70.72.4-1.51.50.1-0.1-0.4-0.80.3-0.6
Time in open arm before self-admin0.10.10.2-0.50.5-0.20.2-0.1-0.0-0.0-0.1
Time in open arm after self-admin0.30.30.70.5-0.5-0.50.5-0.20.8-0.50.5
Bone: periosteal estimation1.12.34.1-2.02.0-1.71.7-1.71.1-0.80.2
Bone: periosteal perimeter3.25.46.4-2.52.5-2.42.4-2.52.1-2.21.7
Bone: post-yield work1.31.72.1-1.21.2-1.51.5-1.41.3-1.31.2
Progressive ratio test 1 active lever presses0.20.20.4-0.0-0.00.4-0.40.2-0.60.5-0.7
Progressive ratio test 1 breakpoint0.30.30.70.2-0.20.5-0.50.4-0.70.6-0.8
Progressive ratio test 1 inactive lever presses0.60.61.4-0.70.70.6-0.60.2-1.20.8-1.1
Progressive ratio test 2 active lever presses0.30.41.1-1.11.10.1-0.1-0.7-0.5-0.1-0.2
Progressive ratio test 2 breakpoint0.30.30.7-0.70.70.5-0.5-0.3-0.80.2-0.4
Progressive ratio test 2 inactive lever presses1.41.65.4-2.32.3-0.10.1-1.0-0.70.1-0.7
Incentive Sensitization - Responses0.10.10.3-0.50.50.4-0.4-0.3-0.3-0.20.3
Incentive Sensitization - Breakpoint0.20.20.4-0.60.70.3-0.3-0.4-0.3-0.30.3
Sum of active levers in priming session hrs 5-61.21.11.91.0-1.0-0.90.9-0.51.4-1.21.4
Progressive ratio1.11.31.81.2-1.11.3-1.31.2-1.11.0-0.8
Food seeking constrained by brief footshock0.60.81.70.8-0.81.0-1.01.3-0.70.7-0.4
Seeking ratio, punishment vs. effort0.50.60.9-0.90.9-1.01.0-0.60.7-0.50.4
Retroperitoneal fat weight1.23.88.20.9-0.9-1.71.7-1.42.7-2.42.9
Reaction time number correct0.20.30.8-0.90.90.0-0.0-0.1-0.50.3-0.6
Reaction time mean minus median4.05.26.0-2.22.2-2.22.2-2.42.3-2.42.3
Reaction time mean minus median AUC1.21.52.1-1.41.5-0.80.8-1.31.0-1.41.4
Reaction time num false alarms0.81.11.9-1.11.2-0.70.7-1.40.9-1.11.1
Reaction time num false alarms AUC1.62.23.7-1.51.6-1.21.2-1.91.3-1.61.6
Reaction time trials correct on left0.20.30.8-0.90.90.0-0.0-0.1-0.50.3-0.6
Reaction time trials on left0.20.30.8-0.90.90.0-0.0-0.1-0.50.3-0.6
Reaction time mean0.50.72.01.4-1.30.7-0.70.60.2-0.40.8
Reaction time mean AUC0.50.61.61.3-1.20.5-0.50.40.3-0.61.0
Median of all reaction times1.72.46.12.5-2.41.5-1.51.4-0.50.20.3
Reaction time omissions0.30.41.2-0.20.3-0.20.2-0.60.7-1.01.1
Reaction time false alarm rate1.52.13.2-1.11.2-1.21.2-1.81.5-1.71.7
Reaction time premature initiation rate0.00.10.1-0.20.3-0.10.10.10.2-0.30.3
Reaction time premature initiations0.10.10.3-0.60.6-0.10.10.20.0-0.20.1
Std. dev. reaction times1.01.42.7-0.70.7-1.01.0-1.11.4-1.61.6
Reaction time trials completed0.20.30.8-0.90.90.0-0.0-0.1-0.50.3-0.6
Reaction time trials AUC0.20.20.8-0.90.90.0-0.0-0.2-0.40.2-0.3
Run reversals in cocaine runway, females0.10.10.20.4-0.40.0-0.0-0.00.2-0.20.4
Run reversals in cocaine runway, males0.60.61.2-0.40.40.9-0.90.4-1.10.8-0.8
Latency to leave start box in cocaine runway0.40.51.11.0-1.00.6-0.60.5-0.40.5-0.5
Latency to leave start box in cocaine runway, F0.80.91.71.3-1.30.5-0.50.8-0.60.9-1.1
Latency to leave start box in cocaine runway, M0.30.30.7-0.60.70.1-0.1-0.70.2-0.70.9
Std. dev. time between licks in bursts0.81.02.2-1.41.5-0.70.7-1.20.6-0.80.6
Total sessions with >9 infusions0.10.10.2-0.10.1-0.20.2-0.40.2-0.30.3
Short access day 1 total inactive lever presses0.60.71.10.1-0.20.9-0.90.8-1.00.9-1.0
Short access day 10 total inactive lever presses0.40.51.0-1.00.9-0.60.6-0.10.00.3-0.9
Short access day 1 total infusions1.31.44.02.0-2.01.0-1.01.0-0.40.5-0.2
Short access day 10 total infusions0.30.30.70.8-0.80.3-0.30.00.2-0.40.7
Short access total infusions1.21.34.12.0-2.00.8-0.81.0-0.20.4-0.2
Short access day 1 locomotion0.30.30.60.7-0.60.8-0.80.3-0.3-0.00.5
Short access day 10 total locomotion0.10.10.4-0.10.2-0.10.1-0.30.4-0.60.6
Short access total locomotion0.30.30.80.7-0.70.1-0.1-0.00.5-0.60.9
One hour access (0.3 mA shock)1.01.12.6-0.80.81.3-1.30.3-1.60.9-0.8
Compulsive drug intake2.82.84.71.8-1.72.2-2.21.5-1.61.2-0.5
One hour access (shock baseline)1.41.64.8-2.22.2-0.80.8-1.20.3-0.70.3
Social response proportion0.70.71.7-1.31.3-0.80.8-0.70.00.3-0.6
Social responses1.82.35.0-2.22.2-1.31.3-1.80.7-0.90.5
Social time1.21.62.81.4-1.31.7-1.71.3-1.20.9-0.2
Soleus weight1.95.67.3-2.72.7-2.72.6-2.52.1-1.91.4
Bone: stiffness0.71.22.1-1.51.5-1.11.1-1.20.7-0.70.4
Tibialis anterior weight5.217.925.3-4.94.8-5.05.0-4.33.8-3.11.7
Time to tail flick, vehicle, before self-admin0.70.72.31.5-1.50.6-0.60.6-0.20.30.1
Time to tail flick, vehicle, after self-admin0.10.10.20.4-0.40.4-0.40.2-0.20.00.3
Time to tail flick, test, before self-admin0.10.10.3-0.40.3-0.20.2-0.2-0.10.3-0.6
Time to tail flick, test, after self-admin0.30.31.11.0-1.1-0.30.3-0.10.5-0.30.4
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.20.20.2-0.2-0.0-0.1-0.20.3
Delta time to tail flick, test, before/after SA0.40.40.80.5-0.5-0.50.5-0.20.8-0.70.9
Tibia length0.41.24.8-1.00.9-0.80.80.1-0.41.3-2.2
Ambulatory time before self-admin1.31.42.7-0.80.9-0.90.9-1.31.2-1.51.6
Ambulatory time after self-admin0.60.71.1-0.60.6-0.70.7-1.00.8-1.01.0
Bone: tissue strength0.40.40.70.5-0.60.6-0.60.3-0.70.7-0.8
Total heroin consumption0.91.14.80.2-0.1-0.30.3-0.51.1-1.52.2
Bone: trabecular number3.45.49.1-2.42.3-3.03.0-2.42.2-1.60.7
Bone: trabecular spacing2.12.84.61.9-1.82.1-2.11.9-1.40.9-0.1
Bone: trabecular thickness7.28.612.5-2.92.8-3.53.5-3.22.9-2.41.6
Bone: trabecular tissue density1.01.42.4-0.70.8-1.01.0-1.61.2-1.41.4
Water consumed over 24 hours0.91.02.7-1.41.30.2-0.20.1-0.91.1-1.6
Number of responses in last shaping day0.10.10.1-0.20.20.2-0.20.1-0.40.2-0.4