Hub : Genes

Timm44

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC intron excision ratio chr12_7421020_7425429 0.11 0.07 7.9e-04 0.08 0.06 0.05 0.06 3.2e-04 1.6e-03 3.6e-03 2.6e-03
2 IC intron excision ratio chr12_7425527_7427060 0.13 0.08 1.4e-04 0.1 0.08 0.06 0.07 6.9e-05 3.7e-04 1.3e-03 7.5e-04
3 Liver gene expression Timm44 0.1 0.07 6.8e-05 0.04 0.04 0.04 0.03 1.3e-05 8.8e-05 4.6e-05 9.8e-05
4 Adipose isoform ratio NM_017267.2 0.06 0.04 6.7e-03 0.02 0.01 0 0 3.1e-03 6.2e-02 1.3e-01 2.8e-01
5 Adipose isoform ratio XM_039089299.2 0.06 0.04 5.8e-03 0.01 0.01 0 0 8.0e-03 4.6e-02 1.7e-01 2.4e-01
6 pVTA intron excision ratio chr12_7425527_7427060 0.1 0.06 3.1e-07 0.07 0.08 0.07 0.07 5.2e-06 6.3e-07 4.1e-06 2.4e-06
7 IC mRNA stability Timm44 0.1 0.06 1.2e-03 0.04 0.05 0.02 0.04 6.0e-03 3.7e-03 3.5e-02 1.0e-02
8 pVTA intron excision ratio chr12_7421020_7425429 0.1 0.06 2.5e-07 0.07 0.07 0.07 0.07 1.7e-06 1.2e-06 5.6e-06 5.5e-06
9 Brain gene expression Timm44 0.06 0.04 2.0e-07 0.06 0.06 0.07 0.05 1.9e-06 2.3e-06 6.0e-07 1.8e-05
10 RMTg gene expression Timm44 0.17 0.1 1.4e-03 0.09 0.07 0.04 0.06 2.9e-03 8.1e-03 3.3e-02 1.2e-02
11 pVTA gene expression Timm44 0.05 0.04 1.4e-03 0.04 0.03 0.03 0.03 5.4e-04 2.5e-03 2.1e-03 1.7e-03
12 PL gene expression Timm44 0.06 0.04 1.5e-05 0.03 0.03 0.03 0.03 3.2e-04 7.2e-04 3.1e-04 4.6e-04
13 NAcc intron excision ratio chr12_7425527_7427060 0.03 0.02 4.6e-03 0.02 0.01 0.01 0.02 7.1e-04 9.5e-03 2.2e-03 1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density3.76.411.2-3.33.33.3-2.62.63.0-2.8-2.92.41.61.11.70.0
Area under the delay curve0.30.31.7-0.00.0-0.00.1-0.10.3-0.3-0.40.51.01.30.90.0
BMI with tail1.96.712.2-3.43.43.5-2.32.33.1-2.6-3.12.41.81.91.80.0
BMI without tail2.16.513.1-3.63.63.6-2.52.53.0-2.7-2.92.11.01.01.40.0
Body weight5.724.852.6-7.17.17.3-5.05.06.0-5.3-5.73.61.81.02.40.0
Weight adjusted by age0.10.20.5-0.70.70.7-0.30.30.2-0.2-0.10.1-0.3-0.3-0.10.0
Bone surface3.86.912.5-3.53.53.4-2.62.63.1-2.8-3.02.51.61.21.60.0
Bone volume4.17.411.9-3.53.53.4-2.62.63.1-2.9-3.12.82.21.72.10.0
Breakpoint value in progressive ratio session1.51.92.9-1.71.71.4-1.71.71.3-1.4-1.31.61.01.01.00.0
Number of licking bursts4.26.911.32.4-2.4-2.42.2-2.2-2.62.52.7-3.2-3.4-3.3-3.20.0
Context. condit. distance diff. score7.28.711.2-3.33.33.3-3.13.13.2-3.2-3.12.82.22.02.32.9
Locomotion velocity, session 10.00.10.2-0.00.0-0.1-0.10.1-0.10.00.00.10.30.40.4-0.5
Locomotion distance, session 10.50.62.41.0-1.0-0.90.6-0.6-0.70.60.6-0.60.20.30.1-1.6
Locomotion velocity, session 20.80.91.31.1-1.1-1.00.9-0.9-0.90.90.9-1.1-0.6-0.8-0.7-1.1
Locomotion distance, session 21.31.77.61.5-1.5-1.40.7-0.7-1.31.01.3-1.4-0.9-0.5-0.6-2.8
Locomotion velocity, session 31.71.93.0-1.41.41.4-1.31.31.4-1.4-1.41.51.31.21.11.7
Locomotion distance, session 30.10.10.3-0.20.20.2-0.50.50.3-0.3-0.30.20.20.60.30.0
Stereotopy head waving bouts, day 30.60.71.7-1.31.31.1-0.90.90.8-0.8-0.80.4-0.2-0.10.20.6
Stereotopy head waving duration, day 30.00.00.1-0.20.2-0.10.2-0.2-0.10.20.1-0.20.1-0.20.1-0.3
Locomotion velocity, session 70.10.20.30.4-0.4-0.40.5-0.5-0.40.40.3-0.30.30.40.1-0.6
Locomotion distance, session 70.10.10.3-0.10.10.1-0.30.30.2-0.2-0.20.20.60.40.4-0.1
Stereotopy head waving bouts, day 70.00.00.10.1-0.1-0.3-0.10.1-0.20.10.20.2-0.20.2-0.10.2
Stereotopy head waving duration, day 70.20.20.50.6-0.6-0.70.4-0.4-0.70.60.6-0.2-0.5-0.0-0.4-0.2
Locomotion velocity, session 80.00.00.10.0-0.00.10.1-0.10.2-0.0-0.1-0.20.1-0.30.2-0.1
Locomotion distance, session 81.21.82.5-1.51.51.5-1.41.41.6-1.5-1.51.01.10.81.10.9
Degree of sensitization distance0.80.81.11.0-1.0-1.01.0-1.0-1.01.00.9-0.8-0.2-0.8-0.5-0.8
Degree of sensitization stereotypy0.10.10.60.1-0.1-0.1-0.10.10.0-0.1-0.10.50.20.40.10.8
Conditioned locomotion0.80.91.2-1.01.00.9-0.90.91.1-1.0-1.10.90.91.01.00.4
Cocaine response after cond. corrected0.10.20.8-0.10.10.10.9-0.9-0.00.4-0.0-0.30.6-0.20.10.1
Cocaine response after cond. not corrected0.91.12.5-1.21.21.2-0.30.31.1-0.7-1.11.01.60.91.11.2
Cocaine response before conditioning4.65.57.2-2.22.22.2-2.72.72.3-2.5-2.32.71.92.42.21.9
Saline control response0.60.73.8-0.20.2-0.0-0.90.9-0.2-0.20.4-0.3-2.0-1.4-1.2-0.2
Bone: connectivity density4.06.211.7-3.43.43.3-2.72.72.9-2.8-2.82.21.00.71.30.0
Bone: cortical apparent density0.10.10.50.2-0.2-0.40.7-0.7-0.20.40.2-0.20.30.20.10.0
Bone: cortical area2.13.35.2-2.32.32.3-1.81.82.1-1.9-2.01.81.31.11.40.0
Bone: cortical porosity0.20.20.60.1-0.1-0.10.1-0.1-0.50.30.5-0.3-0.7-0.8-0.50.0
Bone: cortical porosity0.00.00.10.1-0.1-0.0-0.20.2-0.30.10.30.2-0.4-0.2-0.10.0
Bone: cortical thickness1.22.03.5-1.91.91.8-1.31.31.7-1.5-1.71.21.00.70.90.0
Bone: cortical thickness0.60.71.1-1.11.11.0-1.11.10.9-0.9-0.80.70.1-0.40.20.0
Bone: cortical tissue density0.10.20.70.4-0.4-0.50.8-0.8-0.40.50.3-0.30.20.2-0.00.0
Condit. Reinf. active minus inactive responses0.20.20.8-0.10.10.10.0-0.00.2-0.1-0.20.60.90.50.70.4
Condit. Reinf. active-inactive response ratio0.50.51.1-0.80.80.5-0.40.40.5-0.5-0.61.01.00.80.90.8
Condit. Reinf. active responses0.30.30.9-0.20.20.2-0.50.50.3-0.5-0.40.81.00.90.90.3
Condit. Reinf. inactive responses0.10.20.50.3-0.3-0.2-0.50.5-0.2-0.10.10.20.40.70.4-0.6
Incentive salience index mean0.50.61.5-0.50.50.3-0.70.70.6-0.7-0.61.21.21.01.00.6
Condit. Reinf. lever presses0.81.12.1-0.80.80.6-1.11.10.9-1.1-0.91.41.41.21.30.6
Condit. Reinf. active minus inactive responses0.20.30.5-0.60.60.5-0.70.70.6-0.6-0.50.3-0.2-0.4-0.10.7
Condit. Reinf. active-inactive response ratio0.20.20.70.3-0.3-0.30.0-0.0-0.30.20.4-0.5-0.8-0.6-0.6-0.5
Condit. Reinf. active responses1.42.03.0-1.51.51.4-1.71.71.5-1.6-1.41.50.90.30.71.7
Condit. Reinf. inactive responses1.92.44.2-1.61.61.5-1.71.71.5-1.6-1.51.91.30.61.12.1
Condit. Reinf. lever presses2.33.24.4-1.81.81.8-1.91.91.8-1.8-1.82.11.71.41.62.1
Condit. Reinf. lever reinforcers received1.01.42.4-1.21.21.1-1.51.51.2-1.3-1.11.40.70.20.61.5
Conditioned reinforcement - actives0.50.91.8-1.31.31.4-1.21.21.1-1.0-0.90.2-0.4-0.4-0.30.0
Conditioned reinforcement - inactives0.50.71.90.7-0.7-0.60.4-0.4-0.70.70.8-1.0-1.2-1.4-1.10.0
Conditioned locomotion2.33.06.0-2.12.11.9-2.52.51.8-2.0-1.71.70.30.50.70.0
Patch foraging indifference point 0 sec0.00.00.1-0.10.10.2-0.10.10.2-0.3-0.20.20.20.00.00.0
Patch foraging indifference point AUC0.20.31.6-0.10.10.1-0.20.20.1-0.10.0-0.4-1.0-1.3-0.70.0
Delay disc. indifference point, 0s delay0.20.30.8-0.50.50.50.4-0.40.5-0.1-0.50.20.90.60.70.0
Delay disc. indifference point, 16s delay0.10.10.50.1-0.1-0.20.1-0.10.2-0.2-0.30.10.40.70.40.0
Delay disc. indifference point, 2s delay1.61.86.0-0.80.80.8-0.60.60.9-0.9-1.11.82.52.12.00.0
Delay disc. indifference point, 24s delay0.60.61.31.1-1.1-1.11.0-1.0-0.70.80.7-0.8-0.4-0.3-0.40.0
Delay disc. indifference point, 4s delay1.11.13.1-0.70.70.7-0.50.50.9-0.8-1.01.31.81.71.60.0
Delay disc. indifference point, 8s delay0.10.21.0-0.00.0-0.0-0.30.30.2-0.3-0.30.40.41.00.60.0
Indifference point function ln k0.10.10.40.0-0.0-0.1-0.30.3-0.50.20.5-0.1-0.60.2-0.30.0
Indifference point function log k0.10.10.40.0-0.0-0.1-0.30.3-0.50.20.5-0.1-0.60.2-0.30.0
Patch foraging total patch changes 0 sec0.00.00.10.0-0.00.1-0.20.20.2-0.3-0.20.20.0-0.1-0.10.0
Patch foraging total patch changes 12 sec0.10.20.4-0.60.60.6-0.40.40.5-0.5-0.50.40.2-0.10.20.0
Patch foraging total patch changes 18 sec0.20.31.50.4-0.4-0.50.3-0.3-0.40.30.4-0.4-0.7-1.2-0.80.0
Patch foraging total patch changes 24 sec0.10.20.9-0.00.00.2-0.90.90.4-0.6-0.40.4-0.1-0.30.20.0
Patch foraging total patch changes 6 sec0.10.20.4-0.50.50.5-0.60.60.5-0.6-0.50.50.0-0.20.20.0
Patch foraging time to switch 0 sec0.51.02.90.5-0.5-0.51.7-1.7-0.30.80.2-0.31.61.20.90.0
Patch foraging water rate 0 sec0.61.23.7-1.01.00.9-1.91.90.6-1.1-0.40.5-1.3-1.2-0.80.0
Patch foraging water rate 12 sec0.20.41.7-0.30.30.4-1.31.30.3-0.8-0.20.6-0.40.00.10.0
Patch foraging water rate 18 sec0.20.31.7-0.10.10.1-1.31.30.1-0.6-0.10.6-0.30.20.40.0
Patch foraging water rate 24 sec0.71.03.3-1.01.00.8-1.81.80.4-0.9-0.30.5-1.2-0.6-0.40.0
Patch foraging water rate 6 sec1.21.84.5-1.31.31.3-2.12.11.2-1.6-1.21.50.50.70.80.0
Seeking ratio, delayed vs. immediate footshock4.35.38.42.9-2.9-2.82.7-2.7-2.42.42.3-2.2-1.3-1.6-1.80.0
Distance traveled before self-admin0.10.10.5-0.10.1-0.1-0.40.40.0-0.2-0.10.70.50.50.50.0
Distance traveled after self-admin0.20.30.6-0.20.20.4-0.80.80.6-0.7-0.60.70.20.30.30.0
Extensor digitorum longus weight4.116.026.2-5.05.05.1-4.64.64.7-4.6-4.53.62.01.72.40.0
Bone: elastic displacement0.10.10.2-0.30.30.4-0.30.30.1-0.1-0.0-0.1-0.4-0.5-0.00.0
Bone: elastic work1.52.03.9-1.91.92.0-1.81.81.6-1.6-1.41.10.1-0.10.60.0
Bone: endosteal estimation0.10.31.2-0.40.40.6-0.70.70.2-0.4-0.1-0.1-0.8-1.1-0.40.0
Bone: endosteal perimeter1.22.64.8-1.91.92.0-2.22.21.7-1.9-1.61.70.60.51.00.0
Epididymis fat weight0.72.43.5-1.71.71.6-1.61.61.7-1.6-1.71.91.61.01.60.0
Delta time in closed arm before/after self-admin0.20.20.7-0.40.40.2-0.70.70.0-0.20.00.5-0.5-0.8-0.50.0
Delta time in open arm before/after self-admin0.50.52.20.5-0.5-0.40.6-0.6-0.20.30.10.21.31.51.00.0
Diff in mean of infusions in LGA sessions0.50.61.1-0.90.91.1-1.01.00.8-0.8-0.80.70.30.60.60.0
Delay discount exponential model param0.40.42.00.1-0.10.00.1-0.1-0.40.30.5-0.7-1.1-1.4-1.10.0
Extinction: sum of active levers before priming1.01.12.8-1.01.00.8-0.70.71.1-1.0-1.21.11.71.21.20.0
Active lever presses in extinction session 60.80.81.1-1.01.01.0-1.01.01.1-1.0-1.00.90.70.20.40.0
Bone: final force0.30.40.9-0.90.90.9-0.70.70.6-0.6-0.5-0.0-0.5-0.9-0.40.0
Bone: final moment0.20.31.0-0.60.60.6-0.50.50.4-0.3-0.2-0.2-0.6-1.0-0.60.0
Food consumed during 24 hour testing period0.60.81.70.7-0.7-0.90.5-0.5-1.00.81.0-0.8-1.3-1.2-1.30.0
Glucose0.30.50.90.8-0.8-0.81.0-1.0-0.50.70.4-0.40.90.30.60.0
Heart weight0.20.31.20.1-0.10.2-0.80.80.0-0.30.10.0-0.9-1.1-0.40.0
Delay discount hyperbolic model param0.50.52.10.2-0.2-0.10.1-0.1-0.50.40.6-0.8-1.2-1.5-1.10.0
Intermittent access intake day 1-15 change0.30.62.40.3-0.3-0.10.5-0.5-0.30.50.4-1.2-1.1-1.5-1.10.0
Intermittent access intake escalation0.30.72.70.3-0.3-0.10.5-0.5-0.40.60.5-1.3-1.1-1.7-1.10.0
Intermittent access intake escalation 20.70.81.90.9-0.9-0.71.0-1.0-0.70.90.8-1.3-0.7-1.4-0.90.0
Intermitt. access day 1 inactive lever presses0.20.81.70.9-0.9-0.90.7-0.7-0.80.90.9-1.3-0.8-1.1-1.10.0
Intermitt. access day 15 inactive lever presses0.10.31.4-0.20.20.30.8-0.8-0.10.3-0.0-0.31.20.70.50.0
Intermitt. access escalation Index0.30.41.0-0.40.40.4-1.01.00.4-0.6-0.40.90.40.90.60.0
Intermittent access day 1 total infusions0.10.10.70.4-0.4-0.3-0.40.4-0.1-0.20.10.30.20.80.30.0
Intermittent access day 15 total infusions0.00.00.20.3-0.3-0.0-0.30.3-0.1-0.00.1-0.4-0.2-0.1-0.10.0
Intermittent access terminal intake (last 3 days)0.10.10.20.4-0.4-0.20.2-0.2-0.20.20.2-0.5-0.10.0-0.20.0
Intermittent access total infusions0.10.10.6-0.10.10.2-0.30.30.3-0.3-0.30.30.50.80.30.0
Intermittent access day 1 locomotion0.91.13.9-0.50.50.7-1.21.20.8-1.0-0.81.41.12.01.30.0
Intermittent access day 15 total locomotion0.50.93.1-0.50.50.7-1.71.70.8-1.2-0.70.90.20.70.70.0
Intermittent access total locomotion0.80.91.8-0.50.50.6-1.31.30.8-1.1-0.81.30.91.21.00.0
Intermittent access standard deviation0.30.61.70.6-0.6-0.41.3-1.3-0.50.80.6-1.3-0.3-0.7-0.70.0
Left kidney weight2.913.529.2-5.45.45.2-4.14.14.3-4.0-4.02.30.00.11.00.0
Right kidney weight1.98.921.2-4.64.64.3-3.23.23.3-3.0-3.01.8-0.3-0.30.60.0
Cocaine induced anxiety1.21.63.4-1.21.21.2-1.11.11.3-1.3-1.41.61.91.31.30.0
Post-drug Anxiety1.51.67.8-0.60.60.50.4-0.40.7-0.4-0.91.12.82.41.80.0
Baseline Anxiety2.22.66.91.7-1.7-1.62.6-2.6-1.61.91.5-1.60.10.4-0.30.0
Tail length2.38.919.8-4.44.44.4-3.33.33.4-3.2-3.11.7-0.1-0.60.80.0
Length with tail4.218.339.9-6.36.36.3-4.74.75.0-4.6-4.52.3-0.1-1.10.90.0
Length without tail2.47.818.8-4.34.34.3-2.82.83.4-2.9-3.11.30.0-0.40.50.0
Times rat made contact with spout0.30.42.0-0.00.0-0.1-0.10.1-0.50.30.6-0.3-1.4-1.0-0.90.0
Lifetime Intake0.10.10.70.1-0.10.10.0-0.00.1-0.1-0.10.20.60.80.30.0
Liver weight, left0.50.83.3-0.50.50.3-0.10.1-0.10.20.3-0.8-1.8-1.7-1.60.0
Liver weight, right1.01.73.6-1.91.91.8-1.41.41.4-1.4-1.31.10.20.40.30.0
Locomotor activity0.91.43.4-1.41.41.5-1.91.91.0-1.3-0.90.9-0.5-0.20.10.0
Locomotor testing distance0.20.30.7-0.60.60.7-0.80.80.2-0.4-0.10.2-0.8-0.6-0.40.0
Locomotor testing rearing0.10.10.3-0.50.50.4-0.40.4-0.1-0.00.10.5-0.40.1-0.10.0
Locomotion in novel chamber0.60.83.90.4-0.4-0.3-0.50.5-0.40.00.5-0.4-1.7-2.0-1.30.0
Locomotion in novel chamber post-restriction0.30.51.7-0.50.50.7-1.31.30.4-0.8-0.30.5-0.7-0.6-0.10.0
Fecal boli incidents, locomotor time 10.81.22.6-1.41.41.3-1.61.61.0-1.2-0.91.0-0.5-0.40.00.0
Change in fecal boli incidents, locomotor task0.80.82.20.9-0.9-0.81.5-1.5-0.81.10.8-1.1-0.2-0.2-0.40.0
Time >=10cm from walls, locomotor time 11.11.23.6-0.70.70.8-0.40.40.8-0.7-0.91.51.81.91.60.0
Bouts of movement, locomotor time 10.30.30.7-0.60.60.8-0.70.70.6-0.7-0.50.2-0.3-0.5-0.10.0
Total resting periods, locomotor time 10.40.40.9-0.80.80.9-0.90.90.7-0.8-0.60.4-0.2-0.4-0.00.0
Rest time, locomotor task time 11.31.73.3-1.81.81.8-1.51.51.3-1.3-1.31.10.50.60.70.0
Distance moved, locomotor task time 10.30.51.21.0-1.0-1.10.7-0.7-0.80.70.8-0.4-0.2-0.3-0.50.0
Vertical activity count, locomotor time 10.10.20.50.6-0.6-0.70.2-0.2-0.30.20.3-0.4-0.4-0.4-0.60.0
Time >=10cm from walls, locomotor time 22.23.24.9-2.02.02.2-1.31.31.9-1.7-2.02.01.82.01.90.0
Bouts of movement, locomotor time 21.21.93.2-1.71.71.7-1.81.81.5-1.6-1.41.40.50.80.90.0
Total resting periods, locomotor time 20.91.72.6-1.61.61.6-1.61.61.4-1.4-1.31.20.40.70.80.0
Rest time, locomotor task time 20.50.71.2-1.01.00.9-0.90.90.6-0.7-0.61.10.51.00.90.0
Distance moved, locomotor task time 21.92.23.31.6-1.6-1.61.5-1.5-1.41.51.5-1.8-1.4-1.7-1.70.0
Vertical activity count, locomotor time 20.81.13.80.8-0.8-0.70.5-0.5-0.60.60.7-1.5-1.6-1.9-1.50.0
Light reinforcement 10.10.31.60.2-0.2-0.20.0-0.00.2-0.1-0.20.41.11.30.80.0
Light reinforcement 20.60.91.51.2-1.2-1.21.0-1.0-1.01.01.0-1.1-0.6-0.6-0.70.0
Bone: marrow area0.10.31.2-0.40.40.5-0.70.70.2-0.3-0.1-0.2-0.9-1.1-0.50.0
Bone: maximum diameter1.22.24.1-1.91.92.0-1.61.61.7-1.6-1.61.30.90.61.00.0
Bone: maximum force0.61.01.9-1.41.41.3-1.31.31.1-1.1-1.00.7-0.1-0.40.10.0
Bone: maximum moment0.40.71.2-1.11.11.1-1.11.10.8-0.9-0.70.4-0.3-0.5-0.10.0
Mean time between licks in bursts0.10.20.60.7-0.7-0.50.3-0.3-0.60.50.5-0.30.20.70.40.0
Mean num. licks in bursts1.82.74.5-1.71.71.7-1.61.61.6-1.7-1.62.11.71.81.80.0
Cd content in liver0.30.30.80.8-0.8-0.7-0.30.3-0.50.10.6-0.2-0.9-0.6-0.4-0.7
Co content in liver3.33.97.02.0-2.0-1.81.4-1.4-2.01.72.1-1.9-2.5-2.7-2.3-1.3
Cu content in liver0.00.10.3-0.00.0-0.1-0.30.30.0-0.2-0.00.0-0.40.10.0-0.6
Fe content in liver5.97.28.9-2.62.62.7-2.92.92.7-2.9-2.73.02.12.52.32.7
K content in liver0.50.40.9-0.70.70.6-0.50.50.7-0.6-0.70.80.71.00.70.5
Mg content in liver0.10.10.40.0-0.0-0.20.1-0.1-0.20.20.2-0.3-0.6-0.4-0.5-0.1
Mn content in liver1.82.02.51.4-1.4-1.51.4-1.4-1.51.51.5-1.6-1.2-1.2-1.4-1.3
Na content in liver0.40.41.1-0.80.80.8-0.50.50.7-0.6-0.70.50.10.20.11.1
Rb content in liver0.40.52.00.3-0.3-0.3-0.00.00.1-0.2-0.20.91.41.40.90.3
Se content in liver7.99.311.4-3.23.23.3-2.52.53.3-3.1-3.43.13.23.13.22.5
Sr content in liver1.41.22.40.9-0.9-0.91.1-1.1-1.01.11.0-1.5-1.1-1.3-1.2-1.2
Zn content in liver0.40.50.8-0.90.90.8-0.80.80.6-0.6-0.50.1-0.8-0.7-0.50.8
Bone: minimum diameter0.10.10.40.4-0.4-0.30.2-0.2-0.50.40.5-0.3-0.4-0.6-0.30.0
Time in familiar zone, hab. session 10.60.51.70.4-0.4-0.60.8-0.8-0.80.90.7-0.9-0.4-0.6-0.3-1.3
Time in novel zone, hab. session 10.30.30.4-0.60.60.5-0.60.60.6-0.5-0.50.40.20.30.20.6
Total zone transitions, hab. session 10.10.20.60.6-0.6-0.70.0-0.0-0.20.10.2-0.00.40.10.2-0.8
Total locomotion distance, hab. session 10.71.03.2-0.60.60.4-0.70.71.0-0.9-1.01.31.81.11.30.8
Locomotion velocity, hab. session 10.50.72.8-0.20.2-0.0-0.50.50.6-0.6-0.71.11.71.21.20.5
Time in familiar zone, hab. session 20.10.10.2-0.40.40.10.1-0.10.2-0.0-0.20.10.40.10.30.1
Time in novel zone, hab. session 20.10.10.30.4-0.4-0.3-0.00.0-0.30.10.3-0.2-0.00.20.1-0.6
Total zone transitions, hab. session 20.81.02.01.0-1.0-0.90.7-0.7-0.80.80.9-1.3-1.1-1.4-1.0-1.3
Total locomotion distance, hab. session 20.10.20.40.6-0.6-0.60.3-0.3-0.30.30.3-0.4-0.1-0.4-0.2-0.6
Locomotion velocity, hab. session 20.30.40.70.9-0.9-0.80.5-0.5-0.50.40.5-0.6-0.3-0.6-0.4-0.7
Novel to familiar place preference ratio0.80.81.11.1-1.1-0.81.0-1.0-1.01.01.1-0.8-1.0-0.6-0.9-0.2
Novelty place preference1.01.01.51.2-1.2-0.91.1-1.1-1.21.11.2-0.8-1.0-0.6-1.0-0.2
Time in novel zone, NPP test0.70.71.01.0-1.0-0.70.9-0.9-1.01.01.0-0.7-0.9-0.5-0.80.0
Total zone transitions, NPP test0.00.10.50.0-0.0-0.0-0.30.30.1-0.2-0.0-0.1-0.1-0.20.0-0.7
Total locomotion distance, NPP test1.41.92.9-1.11.11.2-1.31.31.4-1.5-1.41.51.71.71.70.6
Locomotion velocity, NPP test1.01.42.0-0.90.91.0-1.41.41.2-1.4-1.31.31.31.31.30.4
Intraocular pressure2.02.84.4-2.02.02.0-2.12.11.9-2.0-1.81.70.90.71.00.0
Delta distance traveled before/after self-admin0.30.30.80.7-0.7-0.30.5-0.5-0.20.20.3-0.8-0.9-0.7-0.90.0
Delta ambulatory time before/after self-admin0.40.61.01.0-1.0-0.70.8-0.8-0.60.60.6-0.9-0.7-0.5-0.70.0
Parametrial fat weight0.30.71.7-0.90.91.10.1-0.10.9-0.4-0.90.31.31.21.20.0
Pavlov. Cond. lever latency0.30.31.6-0.30.30.30.0-0.0-0.00.10.2-0.5-1.3-1.0-0.90.6
Pavlov. Cond. magazine entry latency0.30.40.7-0.70.70.7-0.80.80.5-0.6-0.50.40.30.60.50.1
Pavlov. Cond. change in total contacts0.40.51.9-0.30.30.3-0.20.20.5-0.4-0.60.41.41.11.1-0.6
Pavlov. Cond. index score0.40.51.0-0.60.60.5-0.70.70.6-0.7-0.70.71.01.01.0-0.2
Pavlov. Cond. latency score0.40.51.3-0.50.50.4-0.60.60.6-0.6-0.60.71.11.11.0-0.2
Pavlov. Cond. lever contacts0.30.31.60.2-0.2-0.3-0.00.00.1-0.1-0.20.51.31.10.9-0.5
Pavlov. Cond. magazine entry number0.81.01.71.1-1.1-1.11.3-1.3-0.91.10.9-0.9-0.7-1.1-1.0-0.2
Pavlov. Cond. intertrial magazine entries0.70.91.71.3-1.3-1.10.7-0.7-1.10.91.1-0.7-0.3-0.4-0.5-1.2
Pavlov. Cond. lever-magazine prob. diff.0.40.51.1-0.60.60.6-0.60.60.6-0.7-0.70.71.11.01.0-0.2
Pavlov. Cond. response bias0.70.81.3-0.90.90.8-1.11.10.9-1.0-0.90.90.91.01.00.2
Pavlov. Cond. lever latency1.01.42.40.9-0.9-0.91.2-1.2-1.01.21.1-1.6-1.4-1.1-1.2-1.3
Pavlov. Cond. magazine entry latency0.50.62.1-0.20.20.3-0.40.40.5-0.5-0.61.11.41.21.10.9
Pavlov. Cond. change in total contacts0.20.40.8-0.20.20.3-0.80.80.4-0.6-0.40.90.60.80.50.8
Pavlov. Cond. index score0.50.71.6-0.30.30.4-0.80.80.6-0.7-0.61.31.21.01.01.0
Pavlov. Cond. latency score0.60.81.8-0.40.40.5-0.80.80.6-0.8-0.71.41.41.11.01.2
Pavlov. Cond. lever contacts1.42.03.5-1.11.11.1-1.41.41.2-1.3-1.31.91.71.51.51.6
Pavlov. Cond. magazine entry number0.20.20.7-0.30.30.10.2-0.2-0.10.20.1-0.8-0.8-0.7-0.5-0.8
Pavlov. Cond. intertrial magazine entries0.10.20.9-0.20.2-0.1-0.30.3-0.2-0.00.2-0.3-0.9-0.6-0.7-0.4
Pavlov. Cond. lever-magazine prob. diff.0.40.51.3-0.20.20.2-0.70.70.4-0.6-0.51.21.11.00.80.9
Pavlov. Cond. response bias1.62.14.1-1.01.01.0-1.51.51.2-1.4-1.32.01.91.71.61.6
Time in closed arm before self-admin0.50.72.20.5-0.5-0.40.3-0.3-0.30.30.4-1.4-1.5-1.5-1.10.0
Time in closed arm after self-admin1.01.04.60.4-0.4-0.4-0.50.5-0.40.10.6-0.8-2.1-2.1-1.50.0
Time in open arm before self-admin0.20.20.5-0.40.40.2-0.70.70.3-0.4-0.30.70.10.50.20.0
Time in open arm after self-admin0.80.84.5-0.50.50.40.0-0.00.4-0.3-0.50.81.72.11.30.0
Bone: periosteal estimation0.61.32.7-1.51.51.6-1.51.51.3-1.3-1.20.80.1-0.20.40.0
Bone: periosteal perimeter2.54.36.1-2.32.32.4-2.52.52.1-2.3-2.12.31.61.51.80.0
Bone: post-yield work1.21.72.6-1.41.41.3-1.61.61.4-1.5-1.41.61.10.91.00.0
Progressive ratio test 1 active lever presses0.10.10.3-0.40.40.5-0.40.40.4-0.4-0.4-0.1-0.4-0.2-0.30.0
Progressive ratio test 1 breakpoint0.10.10.3-0.40.40.5-0.40.40.4-0.4-0.4-0.1-0.4-0.2-0.30.0
Progressive ratio test 1 inactive lever presses0.40.61.90.5-0.5-0.4-0.00.0-0.50.40.6-1.0-1.4-1.4-1.10.0
Progressive ratio test 2 active lever presses0.20.20.80.2-0.20.0-0.20.2-0.10.10.2-0.8-0.9-0.9-0.80.0
Progressive ratio test 2 breakpoint0.20.30.90.3-0.3-0.1-0.20.2-0.10.10.3-0.8-0.9-0.8-0.80.0
Progressive ratio test 2 inactive lever presses0.40.61.5-0.70.70.8-1.21.20.3-0.5-0.1-0.1-1.1-1.0-0.70.0
Incentive Sensitization - Responses0.20.30.60.7-0.7-0.60.5-0.5-0.50.50.5-0.8-0.5-0.3-0.60.0
Incentive Sensitization - Breakpoint0.20.30.60.7-0.7-0.60.5-0.5-0.50.50.5-0.8-0.4-0.2-0.50.0
Sum of active levers in priming session hrs 5-61.41.33.1-1.21.21.1-0.50.51.4-1.0-1.40.71.81.31.30.0
Progressive ratio1.52.33.01.7-1.7-1.71.7-1.7-1.71.71.7-1.4-1.3-1.1-1.40.0
Food seeking constrained by brief footshock0.60.71.31.0-1.0-1.10.9-0.9-1.11.01.0-0.7-0.3-0.2-0.70.0
Seeking ratio, punishment vs. effort0.50.71.1-1.01.01.0-1.01.01.0-1.0-0.90.70.50.40.50.0
Retroperitoneal fat weight0.94.07.7-2.12.12.1-1.11.12.1-1.7-2.22.22.82.32.50.0
Reaction time number correct0.10.20.70.0-0.0-0.2-0.50.5-0.1-0.10.2-0.5-0.8-0.8-0.80.0
Reaction time mean minus median1.84.67.8-2.22.22.2-2.32.31.9-2.2-2.02.81.92.32.20.0
Reaction time mean minus median AUC0.41.12.4-0.70.70.8-1.41.40.7-1.0-0.71.50.91.41.30.0
Reaction time num false alarms0.30.50.9-0.50.50.5-1.01.00.4-0.7-0.40.90.60.90.80.0
Reaction time num false alarms AUC0.71.12.0-0.90.90.9-1.41.40.9-1.2-0.91.40.91.11.20.0
Reaction time trials correct on left0.10.20.70.0-0.0-0.2-0.50.5-0.1-0.10.2-0.5-0.8-0.8-0.80.0
Reaction time trials on left0.10.20.70.0-0.0-0.2-0.50.5-0.1-0.10.2-0.5-0.8-0.7-0.70.0
Reaction time mean0.30.41.20.7-0.7-0.50.7-0.7-0.40.50.30.20.91.10.80.0
Reaction time mean AUC0.20.41.60.6-0.6-0.40.5-0.5-0.30.30.20.41.01.30.90.0
Median of all reaction times1.01.42.81.6-1.6-1.41.7-1.7-1.21.41.1-0.80.40.50.20.0
Reaction time omissions0.30.52.0-0.40.40.4-0.50.50.3-0.5-0.31.10.91.41.20.0
Reaction time false alarm rate1.01.42.8-1.01.01.1-1.21.21.0-1.2-1.01.71.31.41.50.0
Reaction time premature initiation rate0.10.10.3-0.20.20.3-0.50.50.3-0.3-0.30.60.40.20.30.0
Reaction time premature initiations0.10.10.4-0.20.20.1-0.70.70.2-0.3-0.20.30.1-0.1-0.10.0
Std. dev. reaction times0.91.63.6-0.90.91.1-1.11.11.0-1.1-1.01.71.71.91.80.0
Reaction time trials completed0.10.20.70.0-0.0-0.2-0.50.5-0.1-0.10.2-0.5-0.8-0.7-0.70.0
Reaction time trials AUC0.10.10.40.0-0.0-0.2-0.50.5-0.0-0.20.1-0.4-0.6-0.5-0.60.0
Run reversals in cocaine runway, females0.20.20.8-0.10.10.0-0.00.00.3-0.2-0.30.30.80.90.60.0
Run reversals in cocaine runway, males0.70.71.70.9-0.9-0.90.2-0.2-1.00.61.0-0.9-1.3-1.0-1.00.0
Latency to leave start box in cocaine runway0.20.20.70.4-0.4-0.20.9-0.9-0.40.60.4-0.70.20.0-0.10.0
Latency to leave start box in cocaine runway, F0.50.61.80.5-0.5-0.31.3-1.3-0.50.90.5-1.3-0.0-0.4-0.60.0
Latency to leave start box in cocaine runway, M0.10.10.30.1-0.10.1-0.30.3-0.0-0.1-0.00.30.40.60.60.0
Std. dev. time between licks in bursts0.40.61.3-0.60.60.9-1.11.10.6-0.9-0.60.70.20.80.60.0
Total sessions with >9 infusions0.20.30.80.5-0.5-0.50.9-0.9-0.50.70.5-0.6-0.1-0.0-0.30.0
Short access day 1 total inactive lever presses0.10.10.2-0.10.10.30.3-0.3-0.40.40.4-0.3-0.5-0.5-0.40.0
Short access day 10 total inactive lever presses0.10.20.6-0.60.60.70.4-0.40.10.2-0.0-0.8-0.4-0.5-0.50.0
Short access day 1 total infusions0.30.41.10.6-0.6-0.51.1-1.1-0.60.80.5-0.50.30.50.10.0
Short access day 10 total infusions0.50.62.5-0.60.60.7-0.40.40.6-0.6-0.71.01.01.60.90.0
Short access total infusions0.20.30.90.3-0.3-0.20.9-0.9-0.30.50.2-0.10.70.80.20.0
Short access day 1 locomotion0.10.10.5-0.10.10.2-0.50.50.1-0.3-0.10.70.30.20.50.0
Short access day 10 total locomotion0.00.00.3-0.00.00.0-0.20.2-0.20.00.20.2-0.50.2-0.20.0
Short access total locomotion0.10.21.1-0.00.0-0.0-0.00.00.1-0.1-0.20.60.61.00.50.0
One hour access (0.3 mA shock)0.60.72.40.5-0.5-0.2-0.60.6-0.60.20.7-0.7-1.5-1.5-1.10.0
Compulsive drug intake1.31.53.21.8-1.8-1.71.3-1.3-1.41.31.3-1.1-0.6-0.2-0.40.0
One hour access (shock baseline)0.71.03.0-1.11.11.2-1.71.70.9-1.2-0.80.8-0.3-0.5-0.00.0
Social response proportion0.40.51.2-0.80.80.6-0.80.80.8-0.7-0.6-0.0-0.6-1.1-0.60.0
Social responses1.21.53.5-1.41.41.3-1.91.91.4-1.6-1.31.20.20.10.50.0
Social time1.21.73.71.8-1.8-1.91.2-1.2-1.61.41.5-0.9-0.8-0.5-0.90.0
Soleus weight1.95.78.7-2.72.72.9-2.62.62.8-2.8-2.72.31.51.41.70.0
Bone: stiffness0.30.51.1-0.80.80.7-1.11.10.7-0.9-0.70.70.20.00.20.0
Tibialis anterior weight4.615.527.3-5.15.15.2-4.24.24.7-4.5-4.53.42.01.62.20.0
Time to tail flick, vehicle, before self-admin0.30.31.00.3-0.3-0.50.9-0.90.10.2-0.1-0.10.61.00.20.0
Time to tail flick, vehicle, after self-admin0.00.00.10.4-0.4-0.20.2-0.2-0.10.00.1-0.1-0.1-0.1-0.20.0
Time to tail flick, test, before self-admin0.30.31.10.1-0.1-0.00.4-0.4-0.20.30.3-0.9-1.1-0.9-0.90.0
Time to tail flick, test, after self-admin0.20.20.80.3-0.3-0.40.7-0.7-0.00.3-0.0-0.50.90.60.40.0
Delta time to tail flick, vehicle, before/after SA0.10.00.2-0.00.00.1-0.50.5-0.0-0.20.00.20.1-0.20.20.0
Delta time to tail flick, test, before/after SA0.20.21.10.1-0.1-0.20.0-0.00.00.0-0.10.31.01.00.80.0
Tibia length0.41.05.4-0.80.80.70.2-0.20.30.0-0.1-1.0-1.5-2.3-1.60.0
Ambulatory time before self-admin0.91.32.7-1.11.10.9-1.51.51.0-1.1-1.01.61.01.01.20.0
Ambulatory time after self-admin0.50.61.1-0.60.60.6-1.01.00.8-0.9-0.81.00.60.80.70.0
Bone: tissue strength0.20.20.60.5-0.5-0.30.6-0.6-0.50.60.5-0.8-0.5-0.3-0.40.0
Total heroin consumption1.01.13.8-0.40.40.4-0.90.90.8-0.9-0.91.52.01.51.30.0
Bone: trabecular number2.74.58.4-2.92.92.8-2.12.12.5-2.3-2.41.91.20.91.30.0
Bone: trabecular spacing1.52.04.42.1-2.1-2.01.4-1.4-1.61.51.5-0.9-0.4-0.0-0.60.0
Bone: trabecular thickness6.27.812.3-3.53.53.4-2.92.93.2-3.1-3.12.62.11.52.20.0
Bone: trabecular tissue density0.81.22.0-1.11.11.1-1.01.01.1-1.1-1.21.21.41.31.40.0
Water consumed over 24 hours1.21.66.10.5-0.5-0.70.4-0.4-1.00.81.2-1.2-2.5-2.3-2.10.0
Number of responses in last shaping day0.00.00.10.2-0.2-0.00.2-0.2-0.20.20.2-0.00.20.20.20.0