Timeless

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Timeless	0.11	0.07	2.9e-11	0.08	0.09	0.09	0.09	5.0e-09	1.6e-10	2.6e-10	1.9e-10
2	pVTA	gene expression	Timeless	0.11	0.07	7.2e-09	0.1	0.1	0.1	0.1	3.3e-08	1.0e-08	1.1e-08	1.1e-08
3	Adipose	intron excision ratio	chr7_1253409_1254806	0.03	0.03	3.5e-04	0.02	0.03	0.01	0.02	2.5e-03	7.4e-04	5.3e-02	1.9e-03
4	Adipose	gene expression	Timeless	0.3	0.13	0.0e+00	0.24	0.26	0.26	0.25	7.5e-27	2.6e-28	3.1e-28	4.9e-28
5	Adipose	mRNA stability	Timeless	0.18	0.11	0.0e+00	0.14	0.14	0.13	0.14	1.6e-15	2.1e-15	1.2e-14	2.3e-15
6	Liver	gene expression	Timeless	0.25	0.12	0.0e+00	0.23	0.22	0.23	0.23	3.4e-25	1.8e-24	2.4e-25	2.0e-25
7	PL	gene expression	Timeless	0.16	0.1	1.2e-12	0.12	0.11	0.09	0.11	5.3e-13	8.8e-12	2.9e-10	3.1e-12
8	IC	gene expression	Timeless	0.23	0.13	2.6e-06	0.08	0.08	0.08	0.09	3.0e-04	2.3e-04	2.1e-04	1.1e-04
9	NAcc	gene expression	Timeless	0.03	0.02	3.2e-04	0.01	0.02	0.01	0.01	2.6e-03	8.2e-04	2.8e-03	4.2e-03
10	Brain	gene expression	Timeless	0.14	0.11	1.6e-08	0.08	0.08	0.1	0.08	4.8e-08	7.3e-08	2.6e-09	3.1e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10
Bone: apparent density	0.3	0.5	2.1	-0.2	-0.0	0.3	-0.3	-0.6	-0.6	1.0	0.7	1.4	0.6
Area under the delay curve	0.0	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1	-0.1	-0.0	-0.1	0.1	0.0
BMI with tail	8.0	27.6	30.8	5.5	5.6	-5.5	5.5	5.2	5.4	5.3	5.2	4.7	4.6
BMI without tail	1.9	5.9	7.0	2.7	2.7	-2.7	2.6	2.2	2.5	2.5	2.3	2.2	2.0
Body weight	1.0	4.4	5.8	2.4	2.3	-2.4	2.4	2.1	2.2	2.0	1.7	1.6	1.8
Weight adjusted by age	0.0	0.1	0.2	-0.2	-0.2	0.1	-0.1	-0.1	-0.3	-0.4	-0.3	-0.4	0.1
Bone surface	0.6	1.1	2.6	-0.8	-0.7	1.0	-1.1	-1.4	-1.2	0.8	0.8	1.6	0.1
Bone volume	0.6	1.0	3.6	-0.6	-0.4	0.7	-0.8	-1.2	-1.0	1.1	1.0	1.9	0.3
Breakpoint value in progressive ratio session	0.9	1.0	1.2	-1.1	-1.1	1.0	-1.0	-0.9	-0.8	-1.1	-1.0	-1.0	-1.1
Number of licking bursts	2.5	4.0	6.9	2.1	2.0	-2.1	2.1	2.2	2.2	1.5	1.5	1.1	2.6
Context. condit. distance diff. score	0.3	0.4	0.7	0.6	0.6	-0.6	0.6	0.8	0.6	0.6	0.6	0.4	0.8
Locomotion velocity, session 1	0.2	0.2	0.9	0.0	0.1	0.1	-0.1	-0.3	-0.4	0.6	0.5	0.9	0.6
Locomotion distance, session 1	0.3	0.4	0.8	-0.7	-0.6	0.8	-0.8	-0.9	-0.9	0.1	0.0	0.5	-0.4
Locomotion velocity, session 2	1.6	1.9	3.6	-1.5	-1.4	1.5	-1.6	-1.7	-1.9	-0.6	-0.7	-0.0	-1.5
Locomotion distance, session 2	3.2	4.4	7.6	-2.3	-2.2	2.4	-2.4	-2.7	-2.8	-1.5	-1.5	-0.9	-1.7
Locomotion velocity, session 3	4.5	5.1	6.3	-2.4	-2.4	2.4	-2.4	-2.0	-2.1	-2.5	-2.3	-2.2	-1.6
Locomotion distance, session 3	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.3	-0.3	-0.3	-0.4	-0.6	-0.4	-0.3
Stereotopy head waving bouts, day 3	5.6	6.5	7.5	-2.7	-2.7	2.7	-2.7	-2.6	-2.5	-2.5	-2.3	-2.0	-2.5
Stereotopy head waving duration, day 3	3.5	4.2	6.5	-2.2	-2.1	2.2	-2.2	-1.9	-1.9	-2.0	-1.7	-1.6	-2.5
Locomotion velocity, session 7	0.0	0.0	0.1	-0.3	-0.3	0.3	-0.3	-0.1	-0.2	-0.1	0.1	0.1	-0.1
Locomotion distance, session 7	0.2	0.2	0.7	0.4	0.4	-0.5	0.5	0.8	0.7	0.0	0.1	-0.2	0.5
Stereotopy head waving bouts, day 7	0.8	0.9	1.6	-1.2	-1.1	1.2	-1.2	-1.1	-1.2	-0.7	-0.6	-0.3	-0.1
Stereotopy head waving duration, day 7	0.9	1.0	2.1	-1.2	-1.1	1.2	-1.3	-1.4	-1.5	-0.5	-0.5	-0.1	-0.3
Locomotion velocity, session 8	1.4	1.6	3.4	-1.5	-1.4	1.6	-1.6	-1.6	-1.9	-0.8	-0.7	-0.2	-0.3
Locomotion distance, session 8	0.4	0.6	1.3	-0.9	-0.9	0.9	-0.9	-0.9	-1.1	-0.6	-0.6	-0.4	-0.3
Degree of sensitization distance	0.9	0.9	1.4	0.9	0.9	-0.9	0.9	1.1	0.9	0.9	1.0	0.8	1.2
Degree of sensitization stereotypy	0.1	0.2	0.7	0.1	0.1	-0.0	0.0	0.1	-0.0	0.4	0.5	0.7	0.8
Conditioned locomotion	0.8	0.9	1.5	1.1	1.1	-1.2	1.2	1.2	1.1	0.4	0.5	0.0	0.5
Cocaine response after cond. corrected	2.5	3.0	5.3	1.9	1.8	-1.9	1.9	2.3	2.2	1.2	1.3	0.8	1.5
Cocaine response after cond. not corrected	2.5	3.0	5.3	1.9	1.9	-2.0	2.0	2.3	2.1	1.2	1.3	0.7	1.1
Cocaine response before conditioning	0.6	0.7	1.4	-0.8	-0.8	0.8	-0.9	-1.0	-1.0	-0.6	-0.8	-0.5	-1.2
Saline control response	0.3	0.4	0.8	0.8	0.8	-0.9	0.9	0.6	0.6	0.5	0.4	0.3	0.2
Bone: connectivity density	0.2	0.2	1.1	-0.1	-0.0	0.2	-0.3	-0.4	-0.4	0.7	0.6	1.0	0.3
Bone: cortical apparent density	1.1	1.5	2.0	1.3	1.3	-1.3	1.3	1.1	1.0	1.4	1.4	1.3	0.5
Bone: cortical area	0.8	1.3	3.6	0.8	0.9	-0.7	0.7	0.6	0.6	1.7	1.5	1.9	1.1
Bone: cortical porosity	0.1	0.1	0.2	-0.0	0.0	0.1	-0.1	-0.2	-0.2	0.4	0.2	0.5	0.3
Bone: cortical porosity	0.2	0.2	1.0	0.2	0.3	-0.1	0.1	-0.0	-0.1	0.9	0.7	1.0	0.4
Bone: cortical thickness	1.4	2.3	4.4	1.5	1.5	-1.4	1.4	1.0	0.9	2.1	1.8	2.1	0.8
Bone: cortical thickness	0.6	0.7	1.1	1.0	1.0	-1.0	1.1	0.8	0.8	0.8	0.6	0.5	0.5
Bone: cortical tissue density	0.8	1.0	1.4	1.1	1.1	-1.1	1.1	0.9	0.8	1.2	1.2	1.1	0.3
Condit. Reinf. active minus inactive responses	1.6	1.8	2.3	-1.5	-1.5	1.5	-1.5	-1.0	-1.2	-1.5	-1.3	-1.2	-1.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.3	-0.4	0.3	-0.3	0.3	0.3	-0.6	-0.4	-0.6	-0.4
Condit. Reinf. active responses	2.6	3.3	4.4	-2.0	-2.0	2.1	-2.1	-1.9	-2.1	-1.6	-1.5	-1.2	-1.3
Condit. Reinf. inactive responses	1.9	2.3	4.9	-1.6	-1.6	1.7	-1.7	-2.0	-2.2	-1.0	-1.0	-0.6	-0.6
Incentive salience index mean	1.2	1.4	2.1	-1.4	-1.4	1.4	-1.5	-1.2	-1.4	-1.0	-0.9	-0.6	-0.8
Condit. Reinf. lever presses	0.5	0.7	1.7	-0.9	-0.8	1.0	-1.1	-1.2	-1.3	-0.2	-0.1	0.3	0.1
Condit. Reinf. active minus inactive responses	2.1	2.7	4.4	-1.6	-1.6	1.5	-1.5	-1.2	-1.1	-2.0	-2.0	-2.1	-1.7
Condit. Reinf. active-inactive response ratio	0.7	0.9	2.9	-0.6	-0.7	0.5	-0.4	-0.1	-0.0	-1.4	-1.4	-1.7	-0.9
Condit. Reinf. active responses	1.5	2.1	2.6	-1.5	-1.5	1.5	-1.5	-1.3	-1.3	-1.5	-1.6	-1.5	-1.3
Condit. Reinf. inactive responses	0.3	0.4	0.8	-0.7	-0.7	0.8	-0.8	-0.8	-0.9	-0.4	-0.5	-0.2	-0.3
Condit. Reinf. lever presses	2.5	3.5	4.5	-1.8	-1.9	1.8	-1.7	-1.7	-1.6	-2.1	-2.1	-2.1	-1.9
Condit. Reinf. lever reinforcers received	1.1	1.6	2.2	-1.3	-1.3	1.2	-1.2	-1.0	-1.0	-1.4	-1.5	-1.5	-1.1
Conditioned reinforcement - actives	0.0	0.1	0.3	0.2	0.2	-0.2	0.2	0.4	0.2	0.2	0.3	0.2	-0.6
Conditioned reinforcement - inactives	0.4	0.6	1.1	0.9	0.9	-0.9	0.9	1.0	0.8	0.6	0.6	0.4	-0.1
Conditioned locomotion	1.7	2.3	5.2	-1.5	-1.5	1.6	-1.6	-1.5	-1.5	-1.1	-1.1	-0.9	-2.3
Patch foraging indifference point 0 sec	3.3	6.2	8.3	2.5	2.6	-2.5	2.4	2.2	2.2	2.9	2.8	2.7	1.7
Patch foraging indifference point AUC	0.5	0.8	1.4	-0.9	-1.0	0.9	-0.9	-0.4	-0.4	-1.2	-1.0	-1.1	-0.2
Delay disc. indifference point, 0s delay	1.3	1.4	3.6	0.9	1.0	-0.8	0.8	0.5	0.5	1.5	1.5	1.9	1.5
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	-0.5	-0.5	0.5	-0.5	-0.7	-0.6	-0.3	-0.6	-0.3	-0.8
Delay disc. indifference point, 2s delay	0.2	0.2	0.7	0.3	0.4	-0.3	0.2	0.1	0.3	0.6	0.6	0.8	0.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.9	0.4	0.4	-0.4	0.4	0.2	0.3	0.6	0.2	0.4	1.0
Delay disc. indifference point, 4s delay	0.4	0.4	0.8	-0.7	-0.7	0.7	-0.8	-0.9	-0.9	-0.3	-0.3	0.0	-0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.4	0.3	-0.4	0.4	0.4	0.3	-0.2	-0.1	-0.2	0.0
Indifference point function ln k	0.1	0.2	0.7	0.4	0.4	-0.4	0.4	0.3	0.2	0.4	0.4	0.4	-0.8
Indifference point function log k	0.1	0.2	0.7	0.4	0.4	-0.4	0.4	0.3	0.2	0.4	0.4	0.4	-0.8
Patch foraging total patch changes 0 sec	2.9	5.5	7.4	2.4	2.4	-2.3	2.3	2.2	2.2	2.7	2.6	2.6	1.6
Patch foraging total patch changes 12 sec	2.0	2.6	3.1	1.7	1.7	-1.7	1.7	1.8	1.7	1.4	1.4	1.2	1.6
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	0.1	0.1	0.2	0.2	0.2	0.4
Patch foraging total patch changes 24 sec	0.4	0.7	1.3	0.7	0.7	-0.6	0.6	0.6	0.9	1.0	0.8	1.0	1.2
Patch foraging total patch changes 6 sec	2.1	3.2	4.1	1.8	1.8	-1.7	1.7	1.7	1.7	2.0	1.9	1.8	1.6
Patch foraging time to switch 0 sec	0.2	0.4	1.0	0.5	0.5	-0.4	0.4	-0.1	0.1	0.9	0.8	1.0	1.0
Patch foraging water rate 0 sec	0.4	0.8	1.8	1.0	1.0	-1.1	1.1	1.4	1.0	0.6	0.5	0.3	0.3
Patch foraging water rate 12 sec	0.6	1.2	2.6	1.2	1.2	-1.3	1.3	1.6	1.3	0.9	0.8	0.5	0.1
Patch foraging water rate 18 sec	0.3	0.5	1.3	0.4	0.3	-0.5	0.6	1.0	0.9	-0.6	-0.7	-1.1	-0.3
Patch foraging water rate 24 sec	1.5	2.1	4.6	1.7	1.6	-1.9	1.9	2.2	1.8	0.5	0.5	-0.2	0.4
Patch foraging water rate 6 sec	0.4	0.6	1.8	-0.4	-0.4	0.3	-0.2	0.3	0.0	-1.1	-1.1	-1.4	-1.2
Seeking ratio, delayed vs. immediate footshock	1.3	1.6	3.8	-1.3	-1.3	1.4	-1.4	-1.4	-1.1	-0.9	-0.8	-0.6	-1.9
Distance traveled before self-admin	1.4	1.9	2.4	-1.4	-1.4	1.4	-1.4	-1.4	-1.3	-1.3	-1.3	-1.2	-1.5
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	-0.1	-0.1	-0.3	-0.2	-0.1	0.4
Extensor digitorum longus weight	5.0	19.7	24.2	4.9	4.9	-4.9	4.9	4.7	4.7	4.2	4.1	3.4	3.4
Bone: elastic displacement	0.0	0.0	0.3	0.0	0.0	-0.0	0.0	-0.2	-0.2	0.1	-0.1	0.2	-0.5
Bone: elastic work	0.6	0.8	1.7	0.9	0.9	-0.9	0.8	0.6	0.5	1.3	0.9	1.3	0.6
Bone: endosteal estimation	0.6	1.4	2.1	1.0	1.0	-0.9	0.9	1.0	1.2	1.3	1.5	1.4	1.4
Bone: endosteal perimeter	0.3	0.6	1.0	-0.9	-0.8	1.0	-1.0	-1.0	-0.8	-0.3	-0.1	0.0	-0.7
Epididymis fat weight	0.1	0.3	1.1	-0.2	-0.3	0.1	-0.1	0.1	0.2	-0.7	-0.8	-1.0	-0.6
Delta time in closed arm before/after self-admin	1.9	1.7	3.9	1.5	1.4	-1.6	1.6	1.9	2.0	0.7	0.6	0.0	-0.3
Delta time in open arm before/after self-admin	0.8	0.8	3.1	0.8	0.8	-0.8	0.8	0.7	0.6	0.7	0.7	0.7	1.8
Diff in mean of infusions in LGA sessions	1.9	2.3	3.4	-1.5	-1.6	1.5	-1.5	-1.4	-1.3	-1.6	-1.6	-1.5	-1.8
Delay discount exponential model param	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	0.3	0.2	0.1	0.2	0.0	0.1
Extinction: sum of active levers before priming	1.5	1.6	2.9	-1.2	-1.2	1.1	-1.1	-0.8	-0.7	-1.5	-1.6	-1.7	-1.4
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5	-0.5	-0.5	-0.3	-0.3	-0.2	0.3
Bone: final force	3.0	4.8	8.5	1.9	2.0	-1.8	1.8	1.6	1.5	2.7	2.4	2.8	2.9
Bone: final moment	2.9	4.7	8.0	1.9	1.9	-1.8	1.7	1.6	1.5	2.7	2.4	2.8	2.8
Food consumed during 24 hour testing period	0.2	0.3	0.4	0.6	0.7	-0.6	0.6	0.1	0.3	0.6	0.5	0.6	0.3
Glucose	1.4	2.2	3.2	1.5	1.5	-1.5	1.5	1.4	1.7	1.4	1.2	1.2	1.8
Heart weight	0.3	0.4	1.2	-0.5	-0.5	0.4	-0.4	-0.3	-0.3	-0.8	-0.8	-0.9	-1.1
Delay discount hyperbolic model param	0.0	0.0	0.2	-0.2	-0.2	0.2	-0.1	0.1	-0.1	-0.2	-0.2	-0.4	-0.2
Intermittent access intake day 1-15 change	0.3	0.6	1.8	-0.5	-0.6	0.5	-0.5	-0.3	-0.1	-0.9	-0.9	-1.0	-1.3
Intermittent access intake escalation	0.2	0.5	1.4	-0.5	-0.5	0.5	-0.4	-0.3	-0.1	-0.9	-0.9	-1.0	-1.2
Intermittent access intake escalation 2	0.6	0.7	1.2	-0.8	-0.8	0.7	-0.7	-0.5	-0.4	-1.1	-1.0	-1.0	-1.0
Intermitt. access day 1 inactive lever presses	0.2	0.6	2.1	-0.4	-0.5	0.3	-0.3	0.0	-0.1	-1.2	-1.3	-1.4	0.0
Intermitt. access day 15 inactive lever presses	0.6	1.3	1.7	-1.1	-1.1	1.0	-1.0	-1.0	-1.2	-1.2	-1.2	-1.2	-1.3
Intermitt. access escalation Index	0.1	0.1	0.5	0.1	0.1	-0.0	-0.0	-0.3	-0.3	0.4	0.5	0.7	0.4
Intermittent access day 1 total infusions	0.2	0.3	0.5	0.6	0.6	-0.6	0.6	0.7	0.5	0.4	0.5	0.3	0.4
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.1	0.2	-0.1	0.1	0.2	0.1	0.2	0.3	0.2	-0.4
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.2	-0.2	-0.3	0.2	0.2	0.3	-0.4
Intermittent access total infusions	0.2	0.2	0.4	0.4	0.4	-0.4	0.4	0.4	0.2	0.6	0.6	0.5	0.0
Intermittent access day 1 locomotion	0.1	0.2	0.4	0.4	0.4	-0.4	0.5	0.6	0.4	-0.0	-0.1	-0.2	0.4
Intermittent access day 15 total locomotion	0.1	0.2	1.2	-0.2	-0.2	0.2	-0.2	0.0	-0.2	-0.5	-0.4	-0.5	-1.1
Intermittent access total locomotion	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.2	0.0	-0.1	-0.3	-0.3	-0.4	-0.4
Intermittent access standard deviation	0.4	0.8	1.5	-0.9	-0.9	0.9	-0.9	-0.9	-1.0	-0.6	-0.6	-0.4	-1.2
Left kidney weight	0.0	0.1	0.3	0.0	-0.0	-0.0	0.1	-0.2	-0.1	-0.2	-0.3	-0.3	-0.5
Right kidney weight	0.2	0.8	1.5	-0.7	-0.8	0.7	-0.6	-0.7	-0.8	-1.1	-1.2	-1.2	-0.9
Cocaine induced anxiety	1.3	1.8	3.1	-1.6	-1.5	1.6	-1.7	-1.8	-1.4	-0.9	-0.9	-0.5	-1.0
Post-drug Anxiety	0.8	0.9	2.1	-1.1	-1.0	1.2	-1.3	-1.5	-0.9	-0.2	-0.2	0.3	-0.5
Baseline Anxiety	0.0	0.0	0.1	0.1	0.2	-0.1	0.1	0.1	0.1	0.2	0.2	0.2	0.2
Tail length	3.7	14.6	18.2	-3.8	-3.9	3.8	-3.7	-3.8	-3.7	-4.0	-4.3	-3.8	-3.4
Length with tail	1.6	6.9	10.1	-2.5	-2.6	2.4	-2.4	-2.4	-2.5	-2.9	-3.2	-2.9	-2.4
Length without tail	0.2	0.7	1.2	1.0	1.0	-1.0	1.0	1.1	1.0	0.7	0.6	0.4	0.5
Times rat made contact with spout	1.2	1.3	1.8	1.3	1.2	-1.3	1.3	1.3	1.2	0.9	0.8	0.6	1.3
Lifetime Intake	0.8	1.0	1.7	0.9	1.0	-0.9	0.9	0.9	0.7	1.3	1.3	1.2	0.2
Liver weight, left	0.3	0.4	0.7	0.8	0.8	-0.8	0.8	0.4	0.6	0.8	0.6	0.6	-0.1
Liver weight, right	0.2	0.3	0.8	-0.4	-0.4	0.3	-0.3	-0.2	-0.2	-0.7	-0.9	-0.8	0.3
Locomotor activity	3.8	5.9	8.7	-2.5	-2.5	2.5	-2.6	-2.9	-3.0	-1.9	-2.1	-1.6	-2.4
Locomotor testing distance	1.6	2.8	4.0	-1.7	-1.7	1.8	-1.8	-2.0	-2.0	-1.2	-1.3	-1.0	-1.9
Locomotor testing rearing	0.0	0.1	0.2	-0.1	-0.1	0.1	-0.1	-0.2	-0.1	-0.2	-0.4	-0.4	-0.3
Locomotion in novel chamber	0.2	0.2	0.6	0.3	0.4	-0.3	0.3	0.2	0.5	0.5	0.4	0.4	0.8
Locomotion in novel chamber post-restriction	3.5	5.8	6.7	-2.6	-2.6	2.5	-2.5	-2.4	-2.0	-2.5	-2.6	-2.3	-1.8
Fecal boli incidents, locomotor time 1	0.6	0.9	1.6	1.0	1.0	-1.1	1.1	1.1	1.2	0.6	0.5	0.3	1.2
Change in fecal boli incidents, locomotor task	0.7	0.7	1.5	-0.9	-0.9	1.0	-1.0	-1.1	-1.2	-0.4	-0.2	0.1	-0.3
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.6	0.5	0.6	-0.4	0.4	0.2	0.1	1.1	0.9	1.2	0.7
Bouts of movement, locomotor time 1	0.8	0.9	1.2	-0.9	-0.9	0.8	-0.8	-0.8	-1.0	-1.0	-1.1	-1.0	-1.1
Total resting periods, locomotor time 1	1.6	1.8	2.1	-1.3	-1.3	1.3	-1.3	-1.3	-1.4	-1.3	-1.4	-1.3	-1.3
Rest time, locomotor task time 1	0.6	0.7	1.0	-0.9	-0.9	1.0	-1.0	-1.0	-1.0	-0.6	-0.8	-0.5	-0.1
Distance moved, locomotor task time 1	0.6	1.0	2.4	0.8	0.8	-0.7	0.6	0.6	0.4	1.4	1.5	1.5	0.7
Vertical activity count, locomotor time 1	0.7	1.7	2.2	1.4	1.4	-1.3	1.3	1.4	1.4	1.4	1.5	1.2	0.3
Time >=10cm from walls, locomotor time 2	0.8	1.2	1.7	1.2	1.2	-1.2	1.3	1.3	1.3	0.8	0.9	0.7	0.8
Bouts of movement, locomotor time 2	0.3	0.4	1.3	-0.6	-0.5	0.6	-0.6	-1.0	-1.1	-0.1	-0.3	0.2	-0.7
Total resting periods, locomotor time 2	0.2	0.4	1.4	-0.6	-0.5	0.6	-0.7	-1.0	-1.2	-0.1	-0.3	0.3	-0.4
Rest time, locomotor task time 2	0.2	0.2	0.5	-0.4	-0.4	0.4	-0.5	-0.6	-0.7	-0.2	-0.1	0.2	0.4
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.3	0.2	-0.3	0.3	0.5	0.3	0.0	0.0	-0.3	-0.2
Vertical activity count, locomotor time 2	1.0	1.4	2.3	1.3	1.3	-1.4	1.4	1.5	1.5	1.0	0.8	0.4	0.5
Light reinforcement 1	3.1	7.7	11.5	-2.8	-2.7	2.8	-2.8	-3.0	-3.3	-2.3	-2.4	-2.0	-3.4
Light reinforcement 2	1.5	2.3	5.4	-1.3	-1.3	1.3	-1.4	-1.7	-1.9	-1.1	-1.4	-1.0	-2.3
Bone: marrow area	0.6	1.3	2.0	0.9	0.9	-0.8	0.8	0.9	1.2	1.2	1.4	1.4	1.4
Bone: maximum diameter	0.3	0.6	1.2	-1.0	-0.9	1.1	-1.1	-0.9	-0.8	-0.2	-0.3	0.2	-0.6
Bone: maximum force	2.8	4.9	7.4	2.0	2.1	-1.9	1.9	1.8	1.7	2.7	2.5	2.7	2.7
Bone: maximum moment	2.8	4.9	7.4	2.0	2.1	-1.9	1.9	1.7	1.7	2.7	2.5	2.7	2.6
Mean time between licks in bursts	0.4	1.1	2.8	-0.9	-1.0	0.9	-0.9	-0.8	-0.8	-1.0	-0.9	-1.0	-1.7
Mean num. licks in bursts	0.6	1.0	2.2	-0.9	-0.9	0.9	-1.0	-1.1	-1.3	-0.7	-0.8	-0.6	-1.5
Cd content in liver	0.2	0.3	1.0	-0.5	-0.5	0.5	-0.5	-0.5	-0.3	-0.4	-0.0	-0.3	-1.0
Co content in liver	3.2	3.7	6.3	-1.8	-1.8	1.7	-1.7	-2.0	-1.9	-1.9	-1.8	-2.0	-2.5
Cu content in liver	0.4	0.5	1.7	0.5	0.5	-0.4	0.4	0.4	0.3	1.1	1.0	1.3	0.3
Fe content in liver	0.3	0.4	0.8	0.6	0.6	-0.6	0.6	0.9	0.8	0.4	0.4	0.3	0.5
K content in liver	0.9	0.9	1.5	-1.0	-0.9	1.0	-1.0	-1.2	-1.2	-0.6	-0.6	-0.3	-1.0
Mg content in liver	1.2	1.2	1.7	-1.2	-1.2	1.3	-1.3	-1.3	-1.3	-1.0	-1.0	-0.7	-0.4
Mn content in liver	1.7	1.8	3.5	-1.6	-1.5	1.7	-1.7	-1.9	-1.9	-0.6	-0.4	0.1	-0.8
Na content in liver	0.2	0.2	0.7	0.1	0.2	-0.1	0.1	0.2	0.4	0.4	0.4	0.7	0.8
Rb content in liver	0.3	0.3	1.3	0.3	0.3	-0.2	0.2	0.1	0.1	0.9	0.7	1.1	0.5
Se content in liver	0.0	0.0	0.3	-0.1	-0.1	0.1	-0.1	0.2	0.2	-0.1	0.1	-0.0	0.6
Sr content in liver	0.2	0.1	0.6	-0.2	-0.2	0.2	-0.2	-0.2	-0.2	-0.4	-0.3	-0.6	-0.7
Zn content in liver	2.8	3.1	6.4	-1.5	-1.6	1.4	-1.4	-1.1	-1.0	-2.2	-2.4	-2.5	-1.5
Bone: minimum diameter	0.2	0.4	1.5	0.4	0.4	-0.3	0.3	0.2	0.3	1.0	1.0	1.2	0.3
Time in familiar zone, hab. session 1	4.6	4.4	6.1	-2.2	-2.2	2.1	-2.1	-1.7	-1.7	-2.4	-2.5	-2.4	-1.5
Time in novel zone, hab. session 1	3.2	3.2	5.8	1.7	1.8	-1.6	1.6	1.1	1.1	2.3	2.2	2.4	1.4
Total zone transitions, hab. session 1	0.5	0.7	1.3	-1.0	-0.9	1.0	-1.1	-1.1	-1.1	-0.4	-0.4	0.1	0.0
Total locomotion distance, hab. session 1	1.9	2.6	4.9	-1.9	-1.8	2.0	-2.0	-2.1	-2.2	-0.9	-0.9	-0.2	-0.9
Locomotion velocity, hab. session 1	2.0	2.8	4.7	-1.9	-1.8	2.0	-2.0	-2.1	-2.2	-1.1	-1.0	-0.5	-1.3
Time in familiar zone, hab. session 2	5.4	5.7	7.7	-2.2	-2.3	2.1	-2.1	-2.0	-2.2	-2.6	-2.6	-2.7	-2.8
Time in novel zone, hab. session 2	5.9	6.0	8.3	2.2	2.3	-2.2	2.1	2.1	2.2	2.8	2.8	2.9	2.7
Total zone transitions, hab. session 2	0.5	0.7	2.9	0.4	0.5	-0.3	0.2	-0.1	-0.2	1.3	1.3	1.7	0.2
Total locomotion distance, hab. session 2	0.6	0.8	1.9	-0.9	-0.8	0.9	-1.0	-1.3	-1.4	-0.3	-0.3	0.1	-0.8
Locomotion velocity, hab. session 2	0.7	1.0	2.5	-1.0	-0.9	1.1	-1.1	-1.5	-1.6	-0.3	-0.3	0.2	-0.9
Novel to familiar place preference ratio	2.9	3.1	5.4	1.5	1.6	-1.4	1.4	1.4	1.3	2.2	2.1	2.3	2.1
Novelty place preference	1.9	2.0	3.9	1.2	1.3	-1.1	1.1	1.1	1.0	1.8	1.7	2.0	1.6
Time in novel zone, NPP test	2.5	2.7	4.7	1.5	1.5	-1.4	1.3	1.3	1.2	2.0	2.0	2.2	1.8
Total zone transitions, NPP test	0.3	0.4	1.2	0.4	0.5	-0.4	0.3	0.0	-0.0	0.9	0.9	1.1	0.6
Total locomotion distance, NPP test	0.1	0.2	0.6	-0.1	-0.1	0.2	-0.2	-0.6	-0.7	0.4	0.5	0.8	-0.1
Locomotion velocity, NPP test	0.2	0.3	0.9	-0.4	-0.4	0.5	-0.6	-0.9	-1.0	0.1	0.1	0.4	-0.3
Intraocular pressure	0.3	0.5	1.9	-0.4	-0.5	0.3	-0.3	-0.3	-0.2	-1.0	-1.0	-1.4	-0.4
Delta distance traveled before/after self-admin	0.7	0.7	1.7	0.9	0.9	-0.9	0.9	0.9	0.9	0.6	0.7	0.6	1.3
Delta ambulatory time before/after self-admin	0.6	0.8	1.9	0.8	0.8	-0.8	0.8	0.7	0.7	0.8	0.9	0.9	1.4
Parametrial fat weight	0.5	1.2	2.3	1.0	1.0	-1.0	1.0	1.0	1.0	1.1	1.1	1.1	1.5
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.5	0.4	-0.6	0.6	0.8	0.7	-0.1	-0.3	-0.6	0.1
Pavlov. Cond. magazine entry latency	1.6	2.1	2.3	-1.5	-1.5	1.4	-1.4	-1.5	-1.5	-1.4	-1.3	-1.3	-1.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.4	0.4	-0.4	0.4	0.4	0.4	0.5	0.5	0.5	0.4
Pavlov. Cond. index score	0.6	0.7	1.3	-0.9	-0.9	0.9	-1.0	-1.1	-1.1	-0.6	-0.5	-0.3	-0.8
Pavlov. Cond. latency score	0.6	0.8	1.5	-1.0	-0.9	1.0	-1.1	-1.2	-1.2	-0.5	-0.4	-0.1	-0.8
Pavlov. Cond. lever contacts	0.1	0.2	0.5	-0.3	-0.2	0.3	-0.4	-0.6	-0.6	0.3	0.5	0.7	0.1
Pavlov. Cond. magazine entry number	0.7	0.8	1.0	0.9	1.0	-0.9	0.9	0.9	0.8	1.0	0.9	0.9	0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.5	-0.0	-0.1	-0.0	0.1	0.2	0.2	-0.5	-0.5	-0.7	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.2	-0.9	-0.9	1.0	-1.0	-1.1	-1.1	-0.7	-0.6	-0.4	-0.7
Pavlov. Cond. response bias	0.5	0.7	0.8	-0.9	-0.9	0.9	-0.9	-0.9	-0.8	-0.9	-0.8	-0.8	-0.6
Pavlov. Cond. lever latency	1.7	2.4	2.8	1.6	1.6	-1.6	1.6	1.7	1.5	1.5	1.7	1.5	1.1
Pavlov. Cond. magazine entry latency	2.5	3.0	3.4	-1.8	-1.8	1.8	-1.8	-1.8	-1.8	-1.7	-1.8	-1.6	-1.0
Pavlov. Cond. change in total contacts	0.7	1.1	1.5	-1.0	-1.0	1.0	-1.0	-1.0	-1.0	-1.1	-1.1	-1.1	-1.2
Pavlov. Cond. index score	2.0	2.7	3.1	-1.7	-1.7	1.7	-1.7	-1.7	-1.6	-1.7	-1.8	-1.6	-1.3
Pavlov. Cond. latency score	2.3	3.0	3.5	-1.8	-1.8	1.8	-1.8	-1.9	-1.8	-1.7	-1.8	-1.6	-1.2
Pavlov. Cond. lever contacts	1.6	2.2	2.9	-1.5	-1.5	1.5	-1.4	-1.5	-1.3	-1.5	-1.7	-1.6	-1.1
Pavlov. Cond. magazine entry number	2.4	3.0	3.4	1.8	1.9	-1.8	1.8	1.8	1.8	1.7	1.8	1.5	1.2
Pavlov. Cond. intertrial magazine entries	1.0	1.5	2.3	1.3	1.3	-1.4	1.4	1.4	1.5	1.0	1.0	0.8	1.0
Pavlov. Cond. lever-magazine prob. diff.	2.2	3.0	3.3	-1.8	-1.8	1.8	-1.8	-1.8	-1.7	-1.7	-1.8	-1.6	-1.4
Pavlov. Cond. response bias	2.4	3.3	4.2	-1.8	-1.9	1.8	-1.8	-1.8	-1.6	-1.9	-2.0	-1.9	-1.5
Time in closed arm before self-admin	0.1	0.2	0.7	0.1	0.1	-0.0	-0.0	-0.3	-0.2	0.5	0.6	0.8	0.5
Time in closed arm after self-admin	0.7	0.7	1.2	0.9	0.9	-0.9	0.9	0.8	1.1	0.8	0.8	0.7	-0.7
Time in open arm before self-admin	0.0	0.0	0.3	0.1	0.1	-0.1	0.1	0.2	0.0	0.0	0.1	0.0	-0.6
Time in open arm after self-admin	1.6	1.8	4.4	1.4	1.4	-1.4	1.4	1.4	1.0	1.0	1.1	0.9	2.1
Bone: periosteal estimation	0.9	1.9	4.6	1.0	1.1	-0.9	0.9	0.8	1.0	1.9	1.9	2.1	1.5
Bone: periosteal perimeter	0.1	0.2	0.9	-0.2	-0.2	0.3	-0.4	-0.5	-0.4	0.6	0.6	0.9	-0.2
Bone: post-yield work	0.7	1.0	2.7	0.9	0.9	-0.9	0.9	1.0	1.1	0.9	0.9	0.8	1.6
Progressive ratio test 1 active lever presses	0.5	0.7	1.3	0.8	0.8	-0.8	0.8	0.8	0.8	0.7	0.8	0.6	1.1
Progressive ratio test 1 breakpoint	0.6	0.7	1.3	0.8	0.8	-0.8	0.8	0.9	0.8	0.7	0.8	0.6	1.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.3	-0.3	-0.4	-0.3	-0.2	-0.3	-0.5
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2	-0.1	-0.3	-0.0	-0.0	-0.1	-0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.3	-0.3	-0.4	-0.2	-0.2	-0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.6	0.3	0.3	-0.2	0.2	0.1	-0.0	0.8	0.7	0.7	0.1
Incentive Sensitization - Responses	0.4	0.5	0.9	-0.7	-0.7	0.7	-0.7	-0.6	-0.8	-0.7	-0.7	-0.7	-0.9
Incentive Sensitization - Breakpoint	0.5	0.7	1.1	-0.8	-0.8	0.8	-0.8	-0.8	-1.0	-0.8	-0.8	-0.7	-1.0
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.3	-0.3	0.3	-0.3	-0.3	0.0	-0.4	-0.4	-0.4	-0.7
Progressive ratio	1.1	1.7	2.3	1.5	1.4	-1.5	1.5	1.5	1.1	1.1	1.1	0.9	1.2
Food seeking constrained by brief footshock	2.0	2.5	3.3	-1.7	-1.7	1.6	-1.6	-1.5	-1.4	-1.8	-1.8	-1.7	-0.8
Seeking ratio, punishment vs. effort	2.6	3.8	4.4	-2.1	-2.1	2.1	-2.0	-2.0	-1.6	-2.1	-2.0	-1.9	-1.6
Retroperitoneal fat weight	2.4	10.1	13.6	3.4	3.4	-3.4	3.5	3.6	3.7	2.6	2.5	2.0	3.3
Reaction time number correct	0.7	1.3	2.4	1.3	1.2	-1.3	1.4	1.6	1.4	0.7	0.7	0.4	1.0
Reaction time mean minus median	0.7	1.6	1.9	-1.4	-1.4	1.4	-1.4	-1.3	-1.2	-1.2	-1.3	-1.1	-1.1
Reaction time mean minus median AUC	0.7	1.9	3.1	-1.6	-1.6	1.7	-1.7	-1.8	-1.6	-0.9	-0.9	-0.5	-0.5
Reaction time num false alarms	0.4	0.6	1.0	1.0	1.0	-1.0	1.0	0.6	0.4	0.8	0.8	0.7	0.1
Reaction time num false alarms AUC	0.4	0.6	1.2	1.0	1.0	-1.1	1.1	0.6	0.5	0.8	0.6	0.6	-0.0
Reaction time trials correct on left	0.7	1.3	2.4	1.3	1.2	-1.3	1.4	1.6	1.4	0.7	0.7	0.4	1.0
Reaction time trials on left	0.7	1.3	2.3	1.2	1.2	-1.3	1.3	1.5	1.4	0.7	0.7	0.4	1.0
Reaction time mean	1.0	1.6	2.3	-1.5	-1.4	1.5	-1.5	-1.5	-1.3	-1.0	-0.7	-0.6	-1.0
Reaction time mean AUC	0.4	0.6	1.1	-1.0	-0.9	1.0	-1.0	-0.9	-0.8	-0.5	-0.2	-0.2	-0.6
Median of all reaction times	0.6	0.9	1.4	-1.1	-1.1	1.2	-1.2	-1.2	-1.0	-0.7	-0.3	-0.3	-0.9
Reaction time omissions	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.2	-0.2	0.0	0.3	0.4	0.5	-0.1
Reaction time false alarm rate	0.1	0.1	0.3	0.4	0.4	-0.4	0.3	-0.2	-0.2	0.5	0.4	0.5	-0.3
Reaction time premature initiation rate	1.3	1.8	3.1	-1.2	-1.3	1.1	-1.1	-1.1	-1.3	-1.7	-1.5	-1.8	-1.0
Reaction time premature initiations	0.4	0.7	2.5	-0.5	-0.6	0.4	-0.4	-0.1	-0.4	-1.3	-1.2	-1.6	-0.6
Std. dev. reaction times	0.5	0.9	1.4	-1.1	-1.1	1.2	-1.2	-1.1	-0.9	-0.8	-0.6	-0.5	-0.5
Reaction time trials completed	0.7	1.3	2.3	1.2	1.2	-1.3	1.3	1.5	1.4	0.7	0.7	0.4	1.0
Reaction time trials AUC	0.8	1.5	2.7	1.4	1.3	-1.4	1.4	1.6	1.5	0.7	0.7	0.4	1.0
Run reversals in cocaine runway, females	2.7	2.7	3.9	-1.9	-1.8	1.9	-1.9	-1.7	-2.0	-1.5	-1.5	-1.1	-0.8
Run reversals in cocaine runway, males	2.2	2.2	3.1	-1.7	-1.7	1.8	-1.8	-1.6	-1.4	-1.2	-1.2	-0.9	-1.3
Latency to leave start box in cocaine runway	0.2	0.2	0.8	-0.0	0.0	0.1	-0.2	-0.6	-0.4	0.4	0.6	0.9	0.3
Latency to leave start box in cocaine runway, F	0.3	0.3	1.5	-0.1	0.0	0.2	-0.2	-0.5	-0.4	0.5	0.9	1.2	0.5
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.2	0.1	-0.2	0.2	-0.0	0.1	-0.1	-0.2	-0.2	-0.2
Std. dev. time between licks in bursts	0.6	0.8	1.4	-1.0	-1.0	1.1	-1.1	-1.2	-1.1	-0.4	-0.5	-0.1	-0.9
Total sessions with >9 infusions	0.7	0.9	1.6	0.9	0.9	-0.8	0.8	0.7	0.8	1.3	1.2	1.2	-0.2
Short access day 1 total inactive lever presses	0.3	0.4	0.8	-0.5	-0.6	0.5	-0.5	-0.3	-0.5	-0.8	-0.8	-0.9	-0.9
Short access day 10 total inactive lever presses	0.1	0.3	1.2	0.0	-0.1	-0.1	0.1	0.5	0.3	-0.7	-0.8	-1.1	-0.5
Short access day 1 total infusions	0.7	0.9	1.5	0.9	0.9	-0.8	0.8	0.7	0.8	1.2	1.2	1.2	-0.6
Short access day 10 total infusions	0.3	0.3	0.5	0.6	0.6	-0.6	0.6	0.7	0.5	0.6	0.6	0.5	0.4
Short access total infusions	1.0	1.3	2.3	1.1	1.1	-1.0	1.0	0.9	0.8	1.5	1.5	1.4	0.1
Short access day 1 locomotion	0.2	0.3	1.1	-0.4	-0.4	0.4	-0.4	-0.3	-0.3	-0.5	-0.5	-0.6	-1.1
Short access day 10 total locomotion	1.0	1.8	3.8	-1.1	-1.2	1.0	-0.9	-0.3	-0.6	-2.0	-1.8	-1.9	-1.6
Short access total locomotion	0.2	0.2	0.6	-0.3	-0.3	0.3	-0.3	-0.1	-0.1	-0.5	-0.5	-0.6	-0.8
One hour access (0.3 mA shock)	0.2	0.2	0.6	0.5	0.5	-0.5	0.5	0.8	0.6	0.3	0.4	0.2	0.2
Compulsive drug intake	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.3	-0.3	-0.3	-0.0	-0.1	-0.0	-0.3
One hour access (shock baseline)	0.0	0.0	0.1	0.0	-0.0	-0.0	0.0	0.2	0.1	-0.2	-0.1	-0.2	-0.3
Social response proportion	1.1	1.3	2.5	-1.2	-1.2	1.2	-1.2	-1.2	-1.6	-1.0	-1.1	-0.8	-0.2
Social responses	9.5	12.3	15.9	-3.8	-3.7	3.8	-3.8	-3.7	-4.0	-3.3	-3.4	-2.8	-2.3
Social time	1.0	1.4	1.8	1.3	1.3	-1.3	1.3	1.3	1.2	1.0	1.0	0.8	0.9
Soleus weight	5.6	16.4	19.2	4.3	4.4	-4.3	4.3	3.8	3.9	4.2	4.3	3.8	2.9
Bone: stiffness	4.3	7.1	11.2	2.5	2.5	-2.4	2.4	2.4	2.3	2.9	2.8	2.9	3.3
Tibialis anterior weight	1.3	4.5	5.4	2.2	2.2	-2.2	2.2	2.1	2.3	2.2	2.2	2.0	1.6
Time to tail flick, vehicle, before self-admin	1.1	1.2	2.3	-1.2	-1.1	1.2	-1.2	-1.3	-0.9	-0.8	-0.7	-0.4	-1.5
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.8	-0.4	-0.5	0.3	-0.3	-0.0	-0.2	-1.3	-1.1	-1.3	-0.3
Time to tail flick, test, before self-admin	0.7	0.7	1.6	-0.9	-0.9	1.0	-1.0	-1.2	-1.3	-0.3	-0.3	-0.0	-0.6
Time to tail flick, test, after self-admin	0.0	0.0	0.2	-0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2	0.3	0.4	-0.3
Delta time to tail flick, vehicle, before/after SA	1.3	1.2	2.6	1.2	1.1	-1.3	1.3	1.5	1.1	0.2	0.4	-0.0	1.6
Delta time to tail flick, test, before/after SA	0.1	0.2	0.4	0.3	0.2	-0.3	0.4	0.5	0.6	-0.4	-0.4	-0.6	-0.1
Tibia length	1.0	2.7	4.2	-1.7	-1.7	1.6	-1.6	-1.6	-1.6	-1.8	-2.0	-1.8	-0.9
Ambulatory time before self-admin	0.3	0.5	0.7	-0.7	-0.7	0.7	-0.7	-0.7	-0.6	-0.7	-0.7	-0.7	-0.9
Ambulatory time after self-admin	0.0	0.0	0.2	-0.0	-0.0	0.0	-0.0	-0.1	0.1	-0.1	-0.0	0.0	0.4
Bone: tissue strength	5.6	5.6	7.2	2.4	2.4	-2.3	2.3	2.3	2.2	2.7	2.6	2.6	2.1
Total heroin consumption	2.3	2.6	3.3	-1.8	-1.8	1.8	-1.8	-1.7	-1.7	-1.6	-1.6	-1.3	-1.0
Bone: trabecular number	0.4	0.7	1.7	-1.0	-0.9	1.0	-1.1	-1.3	-1.1	-0.3	-0.5	0.2	-0.2
Bone: trabecular spacing	0.5	0.6	1.1	0.8	0.7	-0.9	0.9	1.1	0.9	-0.3	-0.1	-0.9	-0.8
Bone: trabecular thickness	0.8	1.0	3.7	-0.3	-0.1	0.5	-0.5	-0.9	-0.9	1.3	1.0	1.9	1.0
Bone: trabecular tissue density	5.1	7.5	9.1	2.9	2.9	-2.9	2.9	3.0	3.0	2.5	2.7	2.1	2.2
Water consumed over 24 hours	0.5	0.7	1.6	0.8	0.8	-0.7	0.7	0.3	0.4	1.1	1.0	1.3	0.8
Number of responses in last shaping day	1.6	1.8	3.2	-1.2	-1.3	1.2	-1.2	-1.0	-0.8	-1.5	-1.6	-1.5	-1.8