Hub : Genes

Timd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Timd2 0.32 0.12 1.6e-07 0.02 -0 0.05 0 1.0e-03 5.3e-01 5.6e-08 2.2e-01
2 NAcc alternative TSS NM_001013855.1 0.42 0.12 5.8e-06 0 0.01 0.04 0 2.0e-01 2.9e-02 1.3e-06 1.5e-01
3 NAcc alternative TSS XM_006246168.4 0.23 0.11 5.5e-05 0.01 0.01 0.04 0.01 7.0e-03 2.5e-02 2.2e-06 3.6e-03
4 Liver isoform ratio XM_008767669.4 0.74 0.1 0.0e+00 0.19 0.2 0.21 0.2 9.7e-21 3.2e-22 5.7e-23 2.5e-22
5 Liver intron excision ratio chr10_31580269_31600023 0.21 0.13 5.5e-06 0.04 0.03 0.04 0.04 3.8e-05 1.9e-04 6.2e-05 6.4e-05
6 Liver mRNA stability Timd2 0.03 0.04 4.3e-03 0.01 0.01 0.01 0.01 1.8e-02 2.0e-02 2.8e-02 2.6e-02
7 Liver intron excision ratio chr10_31580269_31595832 0.1 0.09 2.9e-05 0.03 0.03 0.03 0.03 2.5e-04 6.8e-04 2.0e-04 3.2e-04
8 Liver alternative TSS XM_008767669.4 0.55 0.14 1.1e-16 0.12 0.11 0.12 0.12 5.2e-13 2.7e-12 1.0e-12 4.4e-13
9 Liver alternative TSS NM_001013855.1 0.56 0.14 5.6e-17 0.12 0.11 0.12 0.12 4.6e-13 2.4e-12 5.0e-13 3.4e-13
10 Liver alternative TSS XM_008767669.4 0.48 0.15 1.6e-15 0.12 0.11 0.11 0.12 8.9e-13 3.8e-12 1.2e-12 6.6e-13
11 Liver gene expression Timd2 0.61 0.08 0.0e+00 0.23 0.28 0.22 0.24 1.0e-25 5.7e-31 1.2e-24 6.9e-27
12 Eye gene expression Timd2 0.87 0.14 7.1e-06 0.1 0.11 0.11 0.1 1.2e-02 1.0e-02 9.8e-03 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.62.85.0-2.21.11.41.8-1.6-1.61.61.5-1.51.51.91.8
Area under the delay curve0.30.31.01.0-1.00.40.6-0.3-0.30.30.4-0.40.40.50.5
BMI with tail0.93.05.4-1.62.31.3-2.31.81.8-1.7-1.71.7-1.7-1.3-1.0
BMI without tail1.03.113.6-3.72.22.0-2.01.41.4-1.4-1.31.3-1.3-0.4-0.4
Body weight0.31.55.8-2.12.42.4-0.70.40.4-0.4-0.30.3-0.30.50.4
Weight adjusted by age0.40.53.7-1.9-0.00.6-0.50.60.6-0.6-0.50.5-0.5-0.3-0.3
Bone surface3.05.56.5-2.52.22.02.3-2.4-2.42.42.3-2.32.32.52.4
Bone volume1.52.75.5-2.30.91.51.7-1.5-1.51.51.5-1.51.51.91.7
Breakpoint value in progressive ratio session0.20.21.00.4-1.00.30.5-0.4-0.40.40.4-0.40.40.30.5
Number of licking bursts0.20.44.5-2.10.3-0.20.20.00.0-0.1-0.00.0-0.00.0-0.0
Context. condit. distance diff. score0.20.20.30.1-0.60.00.4-0.5-0.50.50.5-0.50.50.50.4
Locomotion velocity, session 10.20.21.2-1.1-0.20.40.1-0.1-0.10.10.1-0.10.20.70.2
Locomotion distance, session 10.40.53.60.8-1.9-0.7-0.20.40.4-0.4-0.40.4-0.4-0.1-0.5
Locomotion velocity, session 21.92.23.8-0.10.01.51.6-1.6-1.61.61.6-1.61.61.91.7
Locomotion distance, session 20.10.11.40.1-1.20.30.10.10.1-0.1-0.10.1-0.10.50.1
Locomotion velocity, session 30.60.72.20.9-1.5-0.20.9-0.8-0.80.80.8-0.80.80.70.6
Locomotion distance, session 30.40.42.71.4-1.6-0.40.3-0.1-0.10.10.2-0.20.20.00.0
Stereotopy head waving bouts, day 30.60.72.51.0-1.6-1.01.0-0.6-0.60.50.6-0.60.60.20.3
Stereotopy head waving duration, day 30.20.31.30.1-1.1-0.30.8-0.4-0.40.30.5-0.50.50.40.3
Locomotion velocity, session 70.20.20.7-0.80.30.80.3-0.3-0.30.30.3-0.30.30.80.4
Locomotion distance, session 70.20.20.9-0.90.80.8-0.20.20.2-0.1-0.10.1-0.10.20.1
Stereotopy head waving bouts, day 70.80.92.61.6-1.5-1.11.0-0.7-0.70.70.7-0.70.70.40.3
Stereotopy head waving duration, day 71.41.62.51.1-0.9-0.31.6-1.4-1.41.41.5-1.51.51.21.1
Locomotion velocity, session 80.10.10.7-0.90.30.4-0.1-0.1-0.10.10.0-0.00.00.30.2
Locomotion distance, session 80.81.21.70.8-1.30.31.3-1.2-1.21.11.1-1.11.11.21.1
Degree of sensitization distance0.70.74.1-2.01.70.7-0.50.40.4-0.4-0.40.4-0.4-0.1-0.1
Degree of sensitization stereotypy0.80.82.91.7-0.8-0.81.0-0.9-0.90.90.8-0.80.80.50.4
Conditioned locomotion0.30.30.80.2-0.20.40.6-0.6-0.60.60.6-0.60.60.90.5
Cocaine response after cond. corrected1.72.13.20.6-0.9-1.7-1.41.51.5-1.5-1.41.4-1.4-1.8-1.6
Cocaine response after cond. not corrected3.33.85.51.2-1.7-2.4-1.72.02.0-2.0-1.91.9-1.9-2.3-2.2
Cocaine response before conditioning0.10.10.10.3-0.20.1-0.20.20.2-0.2-0.30.3-0.3-0.2-0.3
Saline control response0.40.53.1-1.80.71.2-0.40.40.4-0.4-0.40.4-0.40.1-0.1
Bone: connectivity density2.23.56.6-2.61.91.61.8-1.8-1.81.81.7-1.71.71.91.9
Bone: cortical apparent density0.40.52.11.1-1.4-1.2-0.10.40.4-0.4-0.40.4-0.4-0.5-0.6
Bone: cortical area1.92.95.1-1.61.22.31.6-1.5-1.51.51.6-1.61.62.21.8
Bone: cortical porosity0.70.81.30.7-0.50.21.1-1.0-1.00.91.0-1.01.00.90.9
Bone: cortical porosity0.10.10.60.2-0.8-0.20.20.00.0-0.00.1-0.10.10.20.0
Bone: cortical thickness0.10.10.7-0.5-0.20.90.00.00.0-0.0-0.00.0-0.00.60.2
Bone: cortical thickness0.20.30.80.6-0.90.10.6-0.5-0.50.40.4-0.40.40.50.3
Bone: cortical tissue density0.40.51.91.1-1.4-1.2-0.10.40.4-0.4-0.40.4-0.4-0.5-0.6
Condit. Reinf. active minus inactive responses1.71.93.60.8-1.5-1.9-1.11.31.3-1.3-1.31.3-1.3-1.6-1.6
Condit. Reinf. active-inactive response ratio0.40.41.20.3-0.9-1.1-0.30.50.5-0.5-0.50.5-0.6-0.7-0.7
Condit. Reinf. active responses1.41.72.3-0.1-1.0-1.3-1.41.31.3-1.3-1.41.4-1.4-1.4-1.5
Condit. Reinf. inactive responses0.20.20.4-0.60.10.1-0.70.40.4-0.4-0.50.5-0.5-0.3-0.4
Incentive salience index mean0.60.81.20.4-1.1-1.0-0.90.80.8-0.8-0.90.9-0.9-0.9-1.0
Condit. Reinf. lever presses0.10.10.8-0.3-0.10.9-0.2-0.1-0.10.10.0-0.00.00.50.3
Condit. Reinf. active minus inactive responses0.10.10.2-0.20.1-0.3-0.30.40.4-0.4-0.40.4-0.4-0.4-0.4
Condit. Reinf. active-inactive response ratio0.40.51.10.5-0.6-0.41.0-0.7-0.70.70.7-0.70.70.60.5
Condit. Reinf. active responses0.70.93.71.9-1.3-1.5-0.30.50.5-0.5-0.60.6-0.6-1.0-0.8
Condit. Reinf. inactive responses1.31.72.51.3-1.1-1.1-1.31.31.3-1.3-1.31.3-1.3-1.6-1.4
Condit. Reinf. lever presses0.40.53.61.9-0.5-1.00.5-0.3-0.30.30.3-0.30.3-0.5-0.0
Condit. Reinf. lever reinforcers received1.01.45.42.3-1.7-1.9-0.30.60.6-0.6-0.70.7-0.7-1.2-1.0
Conditioned reinforcement - actives1.83.112.6-3.51.51.6-2.01.61.6-1.6-1.51.5-1.5-1.0-0.7
Conditioned reinforcement - inactives3.34.812.7-3.62.42.8-2.52.02.0-2.0-2.02.0-2.0-0.9-0.8
Conditioned locomotion1.72.26.1-2.5-1.0-1.5-1.31.51.5-1.5-1.31.3-1.3-1.4-1.3
Patch foraging indifference point 0 sec1.73.115.13.9-3.3-3.00.50.00.0-0.1-0.10.1-0.1-0.9-0.8
Patch foraging indifference point AUC2.43.518.54.3-3.0-2.51.7-1.0-1.01.01.0-1.01.0-0.00.1
Delay disc. indifference point, 0s delay1.31.58.91.5-3.0-2.10.00.50.5-0.5-0.30.3-0.3-0.8-0.6
Delay disc. indifference point, 16s delay0.50.52.1-0.60.61.40.3-0.4-0.40.40.5-0.50.51.00.9
Delay disc. indifference point, 2s delay0.80.93.61.9-1.7-0.6-0.30.80.8-0.8-0.70.7-0.6-0.9-0.6
Delay disc. indifference point, 24s delay2.02.39.3-0.91.93.00.8-1.1-1.11.11.0-1.01.01.91.7
Delay disc. indifference point, 4s delay0.70.73.11.5-1.80.11.0-0.4-0.40.40.7-0.70.70.40.3
Delay disc. indifference point, 8s delay0.10.10.60.1-0.40.80.0-0.1-0.10.1-0.00.00.00.60.2
Indifference point function ln k0.81.49.0-3.01.81.3-0.80.60.6-0.6-0.60.6-0.6-0.1-0.0
Indifference point function log k0.81.49.0-3.01.81.3-0.80.60.6-0.6-0.60.6-0.6-0.1-0.0
Patch foraging total patch changes 0 sec1.73.214.93.9-3.4-3.10.30.20.2-0.3-0.30.3-0.2-1.1-1.0
Patch foraging total patch changes 12 sec3.24.220.24.5-3.7-3.30.20.60.6-0.6-0.40.4-0.4-1.5-1.3
Patch foraging total patch changes 18 sec0.71.04.62.1-1.7-1.90.30.10.1-0.1-0.10.1-0.1-0.7-0.6
Patch foraging total patch changes 24 sec1.73.015.43.9-3.2-2.81.0-0.4-0.40.40.3-0.30.3-0.3-0.4
Patch foraging total patch changes 6 sec2.13.217.04.1-3.5-2.70.9-0.3-0.30.30.3-0.30.3-0.4-0.5
Patch foraging time to switch 0 sec0.91.99.7-3.12.31.8-1.20.60.6-0.7-0.70.7-0.7-0.1-0.1
Patch foraging water rate 0 sec0.91.94.71.3-2.2-1.3-1.11.31.3-1.3-1.21.2-1.2-1.2-1.3
Patch foraging water rate 12 sec0.81.79.3-3.01.32.0-1.00.90.9-0.9-0.80.8-0.80.1-0.1
Patch foraging water rate 18 sec3.75.78.5-0.7-1.5-0.6-2.92.82.8-2.8-2.82.8-2.8-2.1-2.4
Patch foraging water rate 24 sec4.76.510.8-2.4-0.30.6-3.33.03.0-3.0-2.92.9-2.9-1.9-2.3
Patch foraging water rate 6 sec2.63.85.7-1.6-0.70.2-2.32.42.4-2.4-2.22.2-2.2-1.8-1.7
Seeking ratio, delayed vs. immediate footshock0.50.62.61.1-0.8-1.6-0.20.40.4-0.4-0.40.4-0.4-1.0-0.9
Distance traveled before self-admin0.10.20.8-0.70.0-0.90.00.30.3-0.3-0.20.2-0.2-0.7-0.4
Distance traveled after self-admin0.91.18.20.22.90.60.4-0.8-0.80.80.9-0.90.90.20.8
Extensor digitorum longus weight0.62.35.7-2.40.40.5-1.71.71.7-1.7-1.61.6-1.6-1.0-1.1
Bone: elastic displacement1.51.82.70.3-0.5-0.8-1.61.51.5-1.5-1.51.5-1.5-1.4-1.5
Bone: elastic work0.10.20.8-0.70.90.9-0.30.10.1-0.1-0.10.1-0.10.30.1
Bone: endosteal estimation3.47.59.8-1.52.73.02.6-2.8-2.82.82.8-2.82.83.13.0
Bone: endosteal perimeter1.83.94.4-0.92.11.72.0-2.1-2.12.12.1-2.12.12.12.0
Epididymis fat weight0.51.76.8-2.62.22.4-0.1-0.3-0.30.40.4-0.40.41.11.0
Delta time in closed arm before/after self-admin0.30.30.60.8-0.2-0.4-0.40.60.6-0.6-0.60.6-0.6-0.6-0.5
Delta time in open arm before/after self-admin1.31.33.3-1.71.11.8-1.30.90.9-0.9-1.01.0-1.0-0.1-0.6
Diff in mean of infusions in LGA sessions0.81.07.11.5-2.7-1.20.8-0.3-0.30.30.4-0.40.4-0.0-0.0
Delay discount exponential model param0.40.51.8-1.30.8-0.7-0.70.50.5-0.5-0.50.5-0.6-0.7-0.6
Extinction: sum of active levers before priming0.50.62.8-1.70.61.5-0.60.20.2-0.2-0.40.4-0.40.50.2
Active lever presses in extinction session 60.20.20.60.80.1-0.50.6-0.4-0.40.50.6-0.60.60.10.2
Bone: final force3.14.98.0-0.11.12.12.5-2.3-2.32.32.4-2.42.42.82.3
Bone: final moment2.64.26.9-0.21.11.92.3-2.2-2.22.22.2-2.22.22.62.2
Food consumed during 24 hour testing period1.72.45.30.9-1.6-2.3-1.11.41.4-1.4-1.41.4-1.4-2.0-1.6
Glucose0.81.22.00.1-0.0-1.0-1.31.21.2-1.2-1.21.2-1.2-1.4-1.3
Heart weight0.50.81.3-0.6-0.50.81.1-0.9-0.90.90.9-0.90.91.21.0
Delay discount hyperbolic model param0.30.42.0-1.41.1-0.4-0.60.30.3-0.3-0.30.4-0.4-0.4-0.4
Intermittent access intake day 1-15 change0.51.16.8-2.62.01.4-0.1-0.1-0.10.20.1-0.10.10.30.5
Intermittent access intake escalation0.40.95.5-2.31.71.20.1-0.2-0.20.30.2-0.20.20.30.5
Intermittent access intake escalation 23.03.412.3-2.93.53.20.6-1.0-1.01.01.0-1.01.01.21.6
Intermitt. access day 1 inactive lever presses0.20.81.71.30.90.60.7-0.9-0.91.00.9-0.90.90.40.9
Intermitt. access day 15 inactive lever presses0.91.87.5-2.52.72.4-0.1-0.3-0.30.30.3-0.20.20.61.2
Intermitt. access escalation Index0.50.74.61.2-2.1-1.50.8-0.1-0.10.00.1-0.10.1-0.2-0.3
Intermittent access day 1 total infusions3.35.413.4-3.70.10.0-2.62.62.6-2.6-2.52.5-2.5-1.6-1.8
Intermittent access day 15 total infusions2.94.426.3-5.11.91.0-1.91.71.7-1.6-1.61.6-1.6-0.8-0.8
Intermittent access terminal intake (last 3 days)2.73.520.9-4.61.90.9-1.71.51.5-1.5-1.51.5-1.4-0.8-0.7
Intermittent access total infusions4.45.220.6-4.51.20.6-2.42.22.2-2.2-2.22.2-2.2-1.4-1.4
Intermittent access day 1 locomotion3.94.916.9-4.10.61.1-2.62.32.3-2.3-2.32.3-2.3-1.1-1.3
Intermittent access day 15 total locomotion3.05.516.2-4.01.71.7-2.92.32.3-2.3-2.32.3-2.3-1.2-1.2
Intermittent access total locomotion6.17.312.7-3.60.10.1-3.23.13.1-3.1-2.92.9-2.9-2.2-2.2
Intermittent access standard deviation1.83.719.7-4.43.62.9-1.20.50.5-0.5-0.50.5-0.50.10.2
Left kidney weight0.62.910.3-2.33.22.00.9-1.3-1.31.31.3-1.31.31.41.6
Right kidney weight0.62.914.2-3.83.52.6-0.2-0.2-0.20.20.2-0.20.20.60.9
Cocaine induced anxiety0.40.64.1-2.01.2-0.10.3-0.3-0.30.30.5-0.50.5-0.60.7
Post-drug Anxiety0.40.54.3-2.10.9-0.30.0-0.1-0.10.10.1-0.10.1-0.40.3
Baseline Anxiety2.12.517.44.2-2.5-1.71.0-0.6-0.60.60.5-0.50.50.4-0.4
Tail length0.41.47.4-2.70.31.80.7-0.6-0.60.60.7-0.70.71.61.1
Length with tail0.31.54.1-2.00.71.91.1-0.8-0.80.81.0-1.01.01.61.2
Length without tail0.10.21.20.9-1.1-0.30.6-0.0-0.00.00.1-0.10.20.1-0.0
Times rat made contact with spout0.81.03.20.4-1.6-1.8-0.30.70.7-0.7-0.70.7-0.7-1.1-1.0
Lifetime Intake4.55.518.1-4.30.90.3-2.62.42.4-2.4-2.42.4-2.4-1.7-1.7
Liver weight, left0.50.81.0-0.90.9-0.6-1.00.90.9-0.9-0.90.9-0.9-0.9-0.9
Liver weight, right0.10.31.41.2-1.10.00.3-0.3-0.30.30.2-0.20.30.30.2
Locomotor activity1.32.14.10.0-0.4-1.7-1.41.51.5-1.5-1.41.4-1.4-2.0-1.6
Locomotor testing distance2.85.010.80.5-1.9-3.3-1.92.22.2-2.2-2.22.2-2.2-2.7-2.6
Locomotor testing rearing0.91.82.4-0.70.5-1.2-1.51.41.4-1.4-1.51.5-1.5-1.4-1.6
Locomotion in novel chamber1.72.29.92.6-3.1-2.90.7-0.0-0.00.00.2-0.20.1-0.9-0.5
Locomotion in novel chamber post-restriction3.55.621.73.5-3.0-4.7-1.01.31.3-1.3-1.51.5-1.5-2.6-2.3
Fecal boli incidents, locomotor time 11.62.314.7-3.82.51.50.6-0.6-0.60.60.7-0.70.70.91.1
Change in fecal boli incidents, locomotor task2.92.919.54.4-2.0-0.11.3-1.3-1.31.21.1-1.11.10.80.6
Time >=10cm from walls, locomotor time 10.20.20.8-0.20.90.80.1-0.3-0.30.30.2-0.20.20.50.4
Bouts of movement, locomotor time 11.82.17.02.6-0.9-0.41.5-1.5-1.51.51.4-1.41.41.01.1
Total resting periods, locomotor time 11.51.73.41.8-0.40.31.4-1.4-1.41.41.4-1.41.41.11.3
Rest time, locomotor task time 10.30.42.40.50.31.50.3-0.3-0.30.30.5-0.50.50.70.6
Distance moved, locomotor task time 10.40.66.1-2.50.40.10.5-0.4-0.40.30.3-0.30.30.30.4
Vertical activity count, locomotor time 10.20.52.6-1.6-0.7-1.60.7-0.3-0.30.30.2-0.20.20.10.1
Time >=10cm from walls, locomotor time 21.11.68.5-1.82.42.9-0.70.20.2-0.1-0.00.0-0.00.80.4
Bouts of movement, locomotor time 21.11.84.32.1-0.4-0.71.3-1.6-1.61.61.2-1.21.21.31.2
Total resting periods, locomotor time 21.42.57.52.7-0.8-1.41.5-1.7-1.71.71.3-1.31.41.21.1
Rest time, locomotor task time 21.11.413.03.6-1.4-0.80.6-0.6-0.60.60.2-0.20.20.2-0.0
Distance moved, locomotor task time 20.60.75.6-2.40.3-0.2-0.30.60.6-0.6-0.50.5-0.5-0.8-0.2
Vertical activity count, locomotor time 21.21.68.9-3.0-0.2-1.4-0.71.11.1-1.1-0.90.9-0.9-1.0-0.9
Light reinforcement 12.35.67.70.8-1.2-1.8-2.62.62.6-2.6-2.62.6-2.6-2.8-2.7
Light reinforcement 20.10.21.71.30.60.5-0.3-0.1-0.10.10.1-0.10.10.30.1
Bone: marrow area3.57.69.9-1.52.73.02.6-2.8-2.82.82.8-2.82.83.13.0
Bone: maximum diameter2.24.25.4-1.41.92.12.1-2.1-2.12.12.1-2.12.12.32.2
Bone: maximum force5.39.413.9-0.51.92.93.3-3.2-3.23.23.3-3.33.33.73.3
Bone: maximum moment4.88.412.5-0.71.92.83.1-3.1-3.13.13.1-3.13.13.53.2
Mean time between licks in bursts0.20.53.6-1.91.40.7-0.40.20.2-0.2-0.20.2-0.20.00.1
Mean num. licks in bursts0.71.16.02.4-1.5-1.2-0.50.60.6-0.6-0.60.6-0.6-1.0-0.8
Cd content in liver2.12.33.20.6-1.0-0.6-1.81.81.8-1.8-1.81.8-1.8-1.4-1.6
Co content in liver0.00.00.1-0.20.20.1-0.30.20.2-0.1-0.10.1-0.10.2-0.1
Cu content in liver0.40.42.3-1.11.01.5-0.30.10.1-0.1-0.00.0-0.00.50.4
Fe content in liver0.40.51.0-0.80.81.00.7-0.6-0.60.60.7-0.70.70.70.8
K content in liver0.40.40.70.4-0.5-0.30.9-0.6-0.60.60.7-0.70.60.70.5
Mg content in liver0.30.31.20.4-1.1-0.30.7-0.3-0.30.30.4-0.40.40.50.4
Mn content in liver0.50.52.51.6-1.1-0.70.6-0.5-0.50.50.4-0.40.40.50.2
Na content in liver0.10.10.30.5-0.2-0.5-0.30.30.3-0.3-0.40.4-0.4-0.4-0.3
Rb content in liver2.52.94.5-0.2-2.0-1.8-1.41.81.8-1.8-1.71.7-1.7-2.1-1.8
Se content in liver0.30.30.60.8-0.8-0.4-0.50.60.6-0.6-0.60.6-0.6-0.3-0.6
Sr content in liver0.20.20.80.70.4-0.9-0.2-0.0-0.00.0-0.10.1-0.1-0.6-0.3
Zn content in liver0.10.10.50.3-0.10.7-0.00.00.00.10.1-0.10.10.50.3
Bone: minimum diameter2.24.06.2-1.41.42.22.0-2.0-2.02.02.0-2.02.02.52.2
Time in familiar zone, hab. session 13.02.94.8-1.4-0.2-0.0-2.22.02.0-2.0-1.91.9-1.9-1.5-1.6
Time in novel zone, hab. session 15.35.38.12.00.30.12.9-2.7-2.72.72.6-2.62.61.92.1
Total zone transitions, hab. session 15.47.59.30.1-2.8-1.6-3.03.03.0-3.0-3.13.1-3.0-2.5-2.9
Total locomotion distance, hab. session 11.92.73.4-0.1-1.4-1.2-1.81.91.9-1.8-1.81.8-1.8-1.5-1.8
Locomotion velocity, hab. session 12.33.24.4-0.6-1.1-0.9-2.02.12.1-2.1-2.12.1-2.1-1.6-1.9
Time in familiar zone, hab. session 23.73.99.2-2.42.63.01.1-1.5-1.51.51.6-1.61.62.22.0
Time in novel zone, hab. session 21.51.63.21.2-1.4-1.8-0.81.11.1-1.1-1.11.1-1.1-1.6-1.3
Total zone transitions, hab. session 20.70.91.3-0.9-0.9-0.3-1.11.11.1-1.1-1.11.1-1.1-0.4-0.9
Total locomotion distance, hab. session 21.01.41.8-0.9-0.8-0.5-1.31.41.4-1.4-1.31.3-1.3-0.9-1.1
Locomotion velocity, hab. session 21.01.41.9-1.1-0.4-0.3-1.41.41.4-1.4-1.31.3-1.3-0.9-1.1
Novel to familiar place preference ratio2.62.94.21.2-1.5-2.1-1.51.71.7-1.7-1.71.7-1.7-1.9-1.9
Novelty place preference1.41.52.10.8-0.9-1.4-1.11.31.3-1.3-1.21.2-1.2-1.4-1.4
Time in novel zone, NPP test1.21.32.00.8-1.0-1.4-0.91.11.1-1.1-1.11.1-1.1-1.3-1.3
Total zone transitions, NPP test1.42.03.1-0.3-1.8-1.0-1.61.51.5-1.5-1.61.6-1.6-0.9-1.5
Total locomotion distance, NPP test0.20.30.9-0.3-0.9-0.4-0.50.60.6-0.6-0.60.6-0.6-0.3-0.5
Locomotion velocity, NPP test0.30.50.7-0.4-0.8-0.4-0.70.80.8-0.8-0.80.8-0.8-0.5-0.7
Intraocular pressure1.01.52.71.60.90.61.3-1.4-1.41.41.3-1.31.21.01.1
Delta distance traveled before/after self-admin0.50.52.71.31.70.6-0.0-0.5-0.50.50.4-0.40.40.20.4
Delta ambulatory time before/after self-admin0.20.31.31.11.10.2-0.1-0.3-0.30.30.3-0.30.30.10.3
Parametrial fat weight0.81.87.4-2.71.01.8-1.41.21.2-1.2-1.11.1-1.1-0.3-0.4
Pavlov. Cond. lever latency0.60.82.7-1.61.51.30.4-0.4-0.40.40.5-0.50.50.80.7
Pavlov. Cond. magazine entry latency1.01.35.32.1-2.3-1.70.9-0.5-0.50.50.5-0.50.5-0.1-0.0
Pavlov. Cond. change in total contacts1.11.15.62.1-2.4-1.70.4-0.2-0.20.20.1-0.10.1-0.2-0.3
Pavlov. Cond. index score1.21.56.72.2-2.6-1.9-0.10.40.4-0.4-0.50.5-0.5-0.9-0.8
Pavlov. Cond. latency score1.21.56.52.2-2.5-1.9-0.10.40.4-0.4-0.40.4-0.4-0.9-0.8
Pavlov. Cond. lever contacts0.81.04.32.1-1.9-1.5-0.20.30.3-0.3-0.40.4-0.4-0.8-0.6
Pavlov. Cond. magazine entry number0.60.84.6-1.32.21.5-0.2-0.1-0.10.10.2-0.20.20.60.5
Pavlov. Cond. intertrial magazine entries3.54.26.6-2.60.6-0.2-2.52.32.3-2.3-2.22.2-2.2-1.7-1.9
Pavlov. Cond. lever-magazine prob. diff.1.21.56.92.4-2.6-1.8-0.00.30.3-0.3-0.40.4-0.4-0.9-0.8
Pavlov. Cond. response bias0.80.95.01.7-2.2-1.60.6-0.2-0.20.20.1-0.10.1-0.4-0.2
Pavlov. Cond. lever latency0.40.50.9-1.0-0.4-0.2-0.80.80.8-0.8-0.80.8-0.8-0.4-0.6
Pavlov. Cond. magazine entry latency0.00.10.3-0.2-0.3-0.60.30.00.0-0.00.1-0.10.1-0.3-0.0
Pavlov. Cond. change in total contacts0.20.41.51.2-1.0-1.10.20.20.2-0.2-0.10.1-0.1-0.7-0.4
Pavlov. Cond. index score0.20.20.91.0-0.4-0.60.6-0.4-0.40.30.4-0.40.4-0.10.2
Pavlov. Cond. latency score0.10.10.20.4-0.2-0.30.5-0.3-0.30.30.4-0.40.40.00.2
Pavlov. Cond. lever contacts0.50.71.00.70.70.41.0-0.9-0.90.91.0-1.01.00.50.8
Pavlov. Cond. magazine entry number0.30.30.70.40.40.60.4-0.7-0.70.70.5-0.50.50.80.5
Pavlov. Cond. intertrial magazine entries0.20.40.50.4-0.3-0.7-0.70.60.6-0.6-0.70.7-0.7-0.5-0.7
Pavlov. Cond. lever-magazine prob. diff.0.20.31.21.1-0.6-0.80.7-0.4-0.40.40.5-0.50.5-0.10.2
Pavlov. Cond. response bias0.30.41.01.0-0.0-0.40.8-0.6-0.60.60.6-0.60.60.00.4
Time in closed arm before self-admin4.35.58.92.7-1.80.23.0-2.5-2.52.52.5-2.52.52.22.0
Time in closed arm after self-admin1.81.95.12.3-0.70.61.7-1.3-1.31.31.4-1.41.41.11.3
Time in open arm before self-admin1.61.83.1-0.10.1-1.8-1.41.41.4-1.4-1.41.4-1.4-1.6-1.4
Time in open arm after self-admin1.21.32.0-0.70.3-0.7-1.41.11.1-1.1-1.31.3-1.3-1.2-1.4
Bone: periosteal estimation3.88.011.8-1.92.63.32.7-2.8-2.82.82.8-2.82.83.43.1
Bone: periosteal perimeter1.32.22.6-0.61.51.51.5-1.5-1.51.61.5-1.51.51.61.5
Bone: post-yield work0.60.81.70.1-0.40.11.3-1.0-1.01.01.1-1.11.10.71.0
Progressive ratio test 1 active lever presses2.22.712.0-3.51.11.1-1.81.41.4-1.5-1.61.6-1.5-0.8-0.8
Progressive ratio test 1 breakpoint2.22.612.0-3.51.11.2-1.81.41.4-1.4-1.51.5-1.5-0.8-0.7
Progressive ratio test 1 inactive lever presses0.20.43.2-1.80.20.4-0.30.30.3-0.3-0.40.4-0.3-0.30.1
Progressive ratio test 2 active lever presses4.04.731.8-5.62.21.4-1.81.61.6-1.6-1.51.5-1.5-0.6-0.6
Progressive ratio test 2 breakpoint4.35.032.7-5.72.31.4-1.91.61.6-1.6-1.51.5-1.5-0.7-0.7
Progressive ratio test 2 inactive lever presses1.42.213.4-3.72.41.5-1.10.80.8-0.8-0.80.8-0.8-0.5-0.0
Incentive Sensitization - Responses1.31.88.5-2.90.6-0.1-1.31.41.4-1.3-1.21.2-1.2-0.8-0.9
Incentive Sensitization - Breakpoint1.41.810.0-3.20.90.1-1.21.31.3-1.2-1.11.1-1.0-0.7-0.8
Sum of active levers in priming session hrs 5-62.42.28.7-3.02.52.7-1.10.60.6-0.6-0.80.8-0.80.40.1
Progressive ratio1.01.53.40.8-1.1-1.81.6-1.2-1.21.21.3-1.31.30.40.6
Food seeking constrained by brief footshock2.12.58.6-2.91.61.41.1-1.3-1.31.31.4-1.41.31.81.7
Seeking ratio, punishment vs. effort2.13.112.8-3.63.33.3-0.5-0.1-0.10.10.0-0.00.01.01.0
Retroperitoneal fat weight0.52.29.6-3.12.32.8-0.1-0.2-0.20.20.4-0.40.41.31.0
Reaction time number correct4.79.126.4-5.11.93.2-3.52.92.9-2.9-3.03.0-3.0-1.0-1.6
Reaction time mean minus median0.20.41.91.3-1.4-0.70.6-0.2-0.20.20.4-0.40.40.10.0
Reaction time mean minus median AUC0.20.51.20.4-0.30.01.1-0.7-0.70.80.9-0.90.90.60.7
Reaction time num false alarms2.02.83.71.9-1.9-1.5-1.51.71.7-1.7-1.61.6-1.6-1.6-1.7
Reaction time num false alarms AUC2.13.35.62.4-2.4-2.1-1.41.71.7-1.6-1.61.6-1.6-1.7-1.9
Reaction time trials correct on left4.79.126.4-5.11.93.2-3.52.92.9-2.9-3.03.0-3.0-1.0-1.6
Reaction time trials on left5.09.326.5-5.11.83.2-3.53.03.0-3.0-3.13.1-3.1-1.0-1.7
Reaction time mean0.20.40.80.40.90.50.4-0.6-0.60.60.7-0.70.70.40.6
Reaction time mean AUC0.91.42.9-0.41.71.40.8-1.1-1.11.21.3-1.31.31.11.3
Median of all reaction times0.40.62.50.21.60.70.3-0.7-0.70.80.8-0.80.80.50.8
Reaction time omissions1.31.84.7-2.21.20.9-1.81.41.4-1.4-1.41.4-1.4-0.5-0.8
Reaction time false alarm rate2.33.220.04.5-2.6-3.10.7-0.3-0.30.30.4-0.40.4-0.8-0.5
Reaction time premature initiation rate0.71.05.12.3-1.8-1.5-0.30.20.2-0.2-0.40.4-0.4-0.7-0.7
Reaction time premature initiations1.83.35.5-0.7-0.70.2-2.32.02.0-2.1-2.22.2-2.3-1.4-1.8
Std. dev. reaction times0.00.00.00.0-0.10.1-0.20.20.2-0.2-0.00.0-0.0-0.0-0.0
Reaction time trials completed5.09.326.5-5.11.83.2-3.53.03.0-3.0-3.13.1-3.1-1.0-1.7
Reaction time trials AUC4.78.921.4-4.61.52.9-3.63.03.0-3.1-3.23.2-3.2-1.1-1.8
Run reversals in cocaine runway, females2.82.815.6-2.13.92.0-1.90.90.9-0.9-1.01.0-1.0-0.8-0.5
Run reversals in cocaine runway, males2.93.05.40.9-1.0-2.1-1.61.81.8-1.8-1.61.6-1.6-2.3-1.9
Latency to leave start box in cocaine runway0.20.20.50.10.10.50.7-0.5-0.50.50.5-0.60.60.50.6
Latency to leave start box in cocaine runway, F0.40.41.3-1.2-0.11.00.5-0.3-0.30.40.6-0.60.60.80.6
Latency to leave start box in cocaine runway, M0.20.21.50.81.20.40.0-0.1-0.10.0-0.20.2-0.1-0.30.0
Std. dev. time between licks in bursts2.83.721.7-4.72.92.5-1.51.01.0-1.0-1.01.0-1.00.0-0.1
Total sessions with >9 infusions3.94.713.2-3.60.10.2-2.52.32.3-2.3-2.32.2-2.2-1.6-1.7
Short access day 1 total inactive lever presses1.11.42.30.6-1.5-1.2-1.21.31.3-1.2-1.21.2-1.2-1.4-1.0
Short access day 10 total inactive lever presses0.51.24.0-0.22.01.20.8-0.9-0.91.01.1-1.11.10.61.2
Short access day 1 total infusions6.89.014.5-3.80.70.3-3.63.43.4-3.4-3.33.3-3.3-2.6-2.5
Short access day 10 total infusions3.03.97.1-2.70.3-1.0-2.22.12.1-2.1-2.12.1-2.1-1.9-1.9
Short access total infusions3.95.08.3-2.90.1-0.3-2.62.52.5-2.5-2.52.5-2.5-2.0-1.9
Short access day 1 locomotion4.75.87.7-2.7-0.9-1.1-2.82.72.7-2.7-2.62.6-2.5-2.0-2.4
Short access day 10 total locomotion1.52.83.8-1.3-1.2-1.1-1.81.91.9-1.9-1.81.8-1.8-1.7-1.6
Short access total locomotion4.15.07.1-2.7-1.0-0.8-2.62.62.6-2.6-2.42.4-2.4-1.9-2.1
One hour access (0.3 mA shock)2.83.218.5-4.31.81.9-1.61.41.4-1.4-1.31.3-1.3-0.2-0.5
Compulsive drug intake0.70.92.9-1.51.31.70.6-0.4-0.40.30.5-0.50.51.20.8
One hour access (shock baseline)1.01.510.8-3.31.11.1-1.10.80.8-0.8-0.80.7-0.7-0.1-0.2
Social response proportion3.23.74.6-0.6-1.6-1.4-2.22.12.1-2.1-2.12.1-2.1-1.8-2.0
Social responses5.16.610.4-3.0-0.2-0.0-3.22.92.9-2.9-3.03.0-3.0-1.9-2.2
Social time2.02.73.40.3-0.9-1.7-1.91.81.8-1.7-1.81.8-1.8-1.7-1.8
Soleus weight0.72.02.70.3-1.7-0.9-1.21.61.6-1.6-1.51.5-1.5-1.2-1.5
Bone: stiffness4.06.59.60.50.81.93.0-2.8-2.82.82.8-2.82.83.12.7
Tibialis anterior weight0.31.01.8-1.30.41.2-1.21.11.1-1.1-1.01.0-1.0-0.2-0.5
Time to tail flick, vehicle, before self-admin1.01.11.80.3-0.5-0.2-1.41.21.2-1.2-1.11.1-1.1-1.2-1.0
Time to tail flick, vehicle, after self-admin0.40.52.81.7-0.0-1.40.20.20.2-0.2-0.20.2-0.2-1.1-0.5
Time to tail flick, test, before self-admin0.90.92.8-1.70.60.6-1.30.90.9-0.9-1.01.0-1.00.1-0.7
Time to tail flick, test, after self-admin0.30.31.5-1.00.9-1.2-0.00.20.2-0.2-0.40.4-0.4-0.5-0.4
Delta time to tail flick, vehicle, before/after SA0.40.42.51.3-0.4-1.60.4-0.1-0.10.10.0-0.0-0.0-0.5-0.4
Delta time to tail flick, test, before/after SA0.50.63.90.0-0.3-2.01.0-0.4-0.40.30.4-0.40.4-1.00.2
Tibia length3.29.011.50.21.62.23.3-3.3-3.33.33.4-3.43.43.43.2
Ambulatory time before self-admin0.20.20.9-1.00.4-0.1-0.20.40.4-0.5-0.40.3-0.3-0.7-0.4
Ambulatory time after self-admin0.50.64.10.92.00.20.2-0.5-0.50.50.6-0.60.6-0.10.4
Bone: tissue strength0.10.10.50.7-0.4-0.60.4-0.2-0.20.30.3-0.30.30.20.1
Total heroin consumption0.60.71.2-0.7-0.00.4-1.11.01.0-1.0-0.90.9-0.9-0.6-0.8
Bone: trabecular number1.22.15.4-2.31.01.31.5-1.3-1.31.31.3-1.31.31.41.5
Bone: trabecular spacing5.47.29.20.6-2.0-1.7-3.03.03.0-3.0-3.03.0-3.0-2.6-2.9
Bone: trabecular thickness1.31.72.4-1.50.31.31.4-1.2-1.21.21.2-1.21.31.51.4
Bone: trabecular tissue density0.30.51.1-0.60.91.00.4-0.6-0.60.60.5-0.50.51.10.6
Water consumed over 24 hours0.40.62.20.7-1.5-1.21.1-0.5-0.50.50.6-0.60.60.00.2
Number of responses in last shaping day0.40.43.0-0.6-1.1-1.70.20.20.2-0.2-0.20.2-0.2-0.5-0.3