Hub : Genes

Timd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS NM_001013855.1 0.6 0.14 3.3e-07 0 0.06 0.07 0.04 1.1e-01 3.0e-07 7.9e-09 2.4e-05
2 NAcc alternative TSS XM_006246168.3 0.28 0.13 2.5e-03 0 0.01 0.02 0 1.4e-01 8.1e-03 1.0e-03 1.3e-01
3 Liver isoform ratio XM_008767669.3 0.76 0.09 0.0e+00 0.21 0.22 0.22 0.22 7.7e-23 1.3e-24 2.1e-24 1.4e-23
4 Liver intron excision ratio chr10_31079016_31094579 0.1 0.09 2.8e-05 0.04 0.03 0.03 0.03 7.8e-05 7.0e-04 2.4e-04 1.5e-04
5 Liver alternative TSS XM_008767669.3 0.48 0.15 1.5e-15 0.12 0.11 0.12 0.12 7.4e-13 3.5e-12 4.1e-13 2.9e-13
6 Liver alternative TSS NM_001013855.1 0.52 0.14 7.2e-16 0.12 0.1 0.11 0.12 8.9e-13 5.8e-11 1.5e-12 4.1e-13
7 Liver mRNA stability Timd2 0.03 0.03 4.5e-03 0.01 0.01 0.01 0.01 1.7e-02 1.8e-02 2.0e-02 1.9e-02
8 Liver alternative TSS XM_008767669.3 0.51 0.14 1.3e-15 0.12 0.1 0.12 0.12 9.3e-14 1.1e-11 5.0e-13 2.1e-13
9 Liver intron excision ratio chr10_31079016_31098770 0.21 0.13 3.7e-06 0.05 0.03 0.04 0.04 7.3e-06 1.3e-04 1.5e-05 1.4e-05
10 Eye gene expression Timd2 0.65 0.31 9.7e-04 0.04 0.02 0 -0.02 7.7e-02 1.5e-01 3.2e-01 9.8e-01
11 Liver gene expression Timd2 0.65 0.08 0.0e+00 0.26 0.29 0.3 0.26 6.8e-29 1.1e-32 2.8e-34 9.6e-29

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.50.91.30.20.30.9-1.11.1-1.11.1-1.11.1-1.0-0.2
Area under the delay curve0.10.10.1-0.0-0.20.3-0.40.3-0.30.2-0.20.20.2-0.3
BMI with tail1.34.421.6-4.6-3.4-2.31.1-1.11.1-1.21.1-1.1-0.3-1.6
BMI without tail1.02.18.5-2.9-2.6-1.40.5-0.50.5-0.60.5-0.5-0.4-2.0
Body weight0.52.010.1-3.2-2.8-0.7-0.10.1-0.10.1-0.10.1-1.1-1.4
Weight adjusted by age0.80.92.4-1.3-1.6-1.00.6-0.60.7-0.70.8-0.80.8-1.3
Bone surface1.52.73.80.31.01.5-1.81.9-1.91.9-1.91.9-2.0-1.0
Bone volume0.50.81.20.10.00.8-1.01.1-1.11.0-1.11.1-1.0-0.7
Breakpoint value in progressive ratio session0.70.81.30.6-1.1-0.71.0-1.01.0-0.71.0-1.01.10.2
Number of licking bursts0.10.10.5-0.0-0.5-0.40.2-0.20.2-0.20.2-0.2-0.0-0.7
Context. condit. distance diff. score0.30.31.21.10.70.6-0.50.5-0.50.5-0.40.4-0.50.1
Locomotion velocity, session 10.00.00.10.2-0.3-0.2-0.20.2-0.10.00.0-0.0-0.1-0.2
Locomotion distance, session 10.40.52.01.4-0.3-0.40.3-0.30.4-0.50.4-0.40.61.2
Locomotion velocity, session 21.51.72.50.80.41.3-1.61.6-1.61.5-1.61.6-1.3-0.2
Locomotion distance, session 20.10.11.10.5-1.0-0.30.0-0.10.1-0.20.2-0.20.00.0
Locomotion velocity, session 30.70.83.11.70.60.9-0.80.8-0.80.7-0.80.8-0.50.2
Locomotion distance, session 30.20.21.11.0-0.30.2-0.10.1-0.10.0-0.10.10.10.9
Stereotopy head waving bouts, day 30.60.73.11.80.91.1-0.60.6-0.60.6-0.50.5-0.21.1
Stereotopy head waving duration, day 30.30.41.71.30.60.8-0.40.4-0.40.4-0.40.4-0.20.5
Locomotion velocity, session 70.10.10.20.3-0.20.0-0.40.4-0.40.4-0.40.4-0.5-0.2
Locomotion distance, session 70.10.10.6-0.5-0.6-0.50.2-0.20.2-0.10.2-0.20.1-0.7
Stereotopy head waving bouts, day 71.61.87.02.62.41.5-1.00.9-0.90.9-0.90.9-0.40.0
Stereotopy head waving duration, day 72.12.66.12.42.51.9-1.41.4-1.41.4-1.31.3-1.00.6
Locomotion velocity, session 80.10.10.4-0.5-0.6-0.20.0-0.00.10.00.2-0.2-0.40.2
Locomotion distance, session 80.91.34.22.00.81.2-1.21.2-1.11.0-1.01.0-1.10.3
Degree of sensitization distance0.30.32.0-1.4-0.4-0.70.3-0.30.3-0.20.3-0.30.1-0.7
Degree of sensitization stereotypy1.31.44.81.92.21.3-0.90.9-0.90.8-0.90.9-0.5-0.3
Conditioned locomotion0.10.10.50.7-0.20.1-0.30.2-0.20.3-0.20.2-0.30.0
Cocaine response after cond. corrected1.61.82.4-0.40.0-1.31.4-1.51.5-1.51.5-1.51.51.6
Cocaine response after cond. not corrected2.72.94.3-0.0-0.3-1.61.9-1.91.9-1.92.0-2.02.11.7
Cocaine response before conditioning0.10.10.20.3-0.3-0.20.2-0.20.2-0.20.2-0.20.3-0.4
Saline control response0.20.31.5-0.7-0.9-0.2-0.00.0-0.00.10.1-0.1-0.2-1.2
Bone: connectivity density1.01.52.4-0.30.31.2-1.31.4-1.41.4-1.41.4-1.51.1
Bone: cortical apparent density0.30.40.70.4-0.5-0.60.6-0.60.6-0.70.7-0.70.8-0.5
Bone: cortical area1.31.93.10.10.11.1-1.61.6-1.61.6-1.51.5-1.5-1.8
Bone: cortical porosity0.30.31.31.10.40.6-0.50.5-0.40.4-0.40.4-0.40.4
Bone: cortical porosity0.00.10.50.7-0.00.2-0.10.1-0.10.0-0.10.1-0.10.1
Bone: cortical thickness0.10.21.3-0.1-0.8-0.50.1-0.10.1-0.10.2-0.20.4-1.2
Bone: cortical thickness0.70.82.61.61.20.9-0.70.7-0.70.6-0.70.7-0.3-0.9
Bone: cortical tissue density0.20.30.60.4-0.4-0.50.5-0.50.6-0.60.6-0.60.7-0.4
Condit. Reinf. active minus inactive responses1.21.32.20.2-0.5-1.21.3-1.31.3-1.41.3-1.31.5-0.4
Condit. Reinf. active-inactive response ratio0.20.30.40.2-0.5-0.50.6-0.60.6-0.60.5-0.50.60.0
Condit. Reinf. active responses1.41.72.3-0.3-0.8-1.51.4-1.41.4-1.51.4-1.41.4-1.4
Condit. Reinf. inactive responses0.30.42.3-0.4-0.2-0.70.4-0.40.4-0.50.4-0.40.3-1.5
Incentive salience index mean0.50.60.80.1-0.6-0.80.8-0.80.8-0.90.8-0.80.8-0.7
Condit. Reinf. lever presses0.10.21.2-0.3-0.7-0.1-0.10.0-0.0-0.0-0.00.0-0.4-1.1
Condit. Reinf. active minus inactive responses0.30.32.5-0.2-0.2-0.40.4-0.40.4-0.40.4-0.40.2-1.6
Condit. Reinf. active-inactive response ratio0.60.61.51.20.80.7-0.70.7-0.70.7-0.70.7-0.7-0.8
Condit. Reinf. active responses0.30.41.51.20.80.00.4-0.40.4-0.50.4-0.40.7-0.9
Condit. Reinf. inactive responses0.91.22.30.0-0.2-0.91.3-1.31.3-1.31.2-1.21.50.0
Condit. Reinf. lever presses0.30.42.41.11.60.5-0.20.2-0.20.1-0.10.10.00.8
Condit. Reinf. lever reinforcers received0.40.61.81.31.0-0.10.6-0.60.6-0.60.6-0.60.9-0.6
Conditioned reinforcement - actives2.42.44.6-1.7-2.1-1.61.5-1.51.5-1.51.5-1.51.01.1
Conditioned reinforcement - inactives5.05.712.2-3.5-3.3-2.52.3-2.22.2-2.02.0-2.01.9-1.5
Conditioned locomotion1.92.33.3-1.0-1.8-1.71.6-1.61.6-1.61.6-1.61.40.9
Patch foraging indifference point 0 sec0.91.410.33.21.40.70.0-0.00.00.00.1-0.10.41.5
Patch foraging indifference point AUC2.12.511.03.32.21.7-0.90.9-0.90.9-0.80.8-0.21.9
Delay disc. indifference point, 0s delay0.40.42.41.60.40.20.3-0.30.3-0.30.4-0.40.51.0
Delay disc. indifference point, 16s delay0.50.61.9-1.0-0.70.5-0.70.7-0.60.5-0.60.6-0.3-1.4
Delay disc. indifference point, 2s delay0.40.51.00.2-0.0-0.40.7-0.80.8-0.80.8-0.81.00.6
Delay disc. indifference point, 24s delay1.51.43.6-1.8-1.10.6-1.11.0-1.00.9-1.01.0-1.0-1.9
Delay disc. indifference point, 4s delay0.70.72.71.60.80.8-0.70.7-0.70.6-0.60.6-0.21.2
Delay disc. indifference point, 8s delay0.10.10.6-0.2-0.80.0-0.10.1-0.10.0-0.10.10.3-0.2
Indifference point function ln k0.91.25.7-2.4-1.8-1.20.7-0.70.7-0.70.7-0.70.0-0.3
Indifference point function log k0.91.25.7-2.4-1.8-1.20.7-0.70.7-0.70.7-0.70.0-0.3
Patch foraging total patch changes 0 sec0.91.510.13.21.30.60.2-0.20.2-0.20.3-0.30.71.9
Patch foraging total patch changes 12 sec1.41.88.02.81.40.40.5-0.50.6-0.60.6-0.61.32.3
Patch foraging total patch changes 18 sec0.40.52.41.61.20.30.0-0.10.1-0.10.2-0.20.41.0
Patch foraging total patch changes 24 sec1.31.611.13.32.01.3-0.30.3-0.30.3-0.30.30.30.7
Patch foraging total patch changes 6 sec1.31.910.33.21.01.1-0.30.4-0.40.3-0.40.4-0.02.8
Patch foraging time to switch 0 sec1.11.76.7-2.6-1.6-1.40.8-0.80.8-0.80.8-0.80.5-1.8
Patch foraging water rate 0 sec0.61.01.50.3-0.9-0.91.1-1.11.1-1.11.1-1.10.91.2
Patch foraging water rate 12 sec1.52.47.3-2.7-2.7-1.20.7-0.70.7-0.80.7-0.7-0.3-2.6
Patch foraging water rate 18 sec4.76.38.8-1.6-3.0-2.82.7-2.72.7-2.62.7-2.72.6-1.0
Patch foraging water rate 24 sec5.57.714.8-2.9-3.8-3.12.7-2.82.8-2.82.8-2.82.2-0.6
Patch foraging water rate 6 sec3.04.36.0-2.5-2.4-2.12.1-2.12.1-2.12.0-2.01.9-1.3
Seeking ratio, delayed vs. immediate footshock0.30.41.71.20.3-0.10.4-0.40.4-0.30.4-0.40.31.3
Distance traveled before self-admin0.70.84.1-2.0-0.5-0.70.6-0.70.7-0.90.7-0.70.3-0.9
Distance traveled after self-admin1.21.35.9-2.30.80.2-0.50.5-0.50.3-0.40.4-1.0-2.4
Extensor digitorum longus weight0.83.26.4-1.8-2.5-2.11.7-1.81.8-1.81.8-1.81.5-0.3
Bone: elastic displacement1.61.82.6-0.4-0.8-1.41.5-1.51.5-1.61.4-1.41.61.0
Bone: elastic work0.00.10.3-0.5-0.3-0.30.2-0.20.1-0.20.1-0.10.00.1
Bone: endosteal estimation3.27.011.10.51.62.7-3.03.0-3.03.0-3.03.0-3.3-0.8
Bone: endosteal perimeter2.14.45.90.21.72.1-2.42.4-2.42.4-2.42.4-2.4-0.7
Epididymis fat weight0.30.71.9-0.4-0.20.4-1.01.0-1.00.9-1.01.0-1.4-0.2
Delta time in closed arm before/after self-admin0.30.32.50.40.3-0.10.1-0.10.1-0.20.2-0.2-0.1-1.6
Delta time in open arm before/after self-admin2.92.87.6-2.8-2.3-2.01.5-1.51.5-1.51.4-1.41.10.4
Diff in mean of infusions in LGA sessions0.40.41.51.2-0.7-0.30.4-0.40.4-0.40.5-0.50.71.1
Delay discount exponential model param0.10.10.3-0.2-0.0-0.50.5-0.50.5-0.30.4-0.4-0.10.3
Extinction: sum of active levers before priming1.31.32.5-0.9-1.6-1.51.1-1.11.1-0.80.9-0.90.9-1.5
Active lever presses in extinction session 60.10.10.3-0.00.1-0.1-0.10.0-0.00.10.1-0.1-0.50.5
Bone: final force2.03.34.31.01.21.7-2.12.1-2.12.1-2.02.0-2.1-1.1
Bone: final moment1.72.73.70.91.01.5-1.91.9-1.91.9-1.81.8-1.9-1.0
Food consumed during 24 hour testing period1.41.72.4-0.7-1.3-1.11.5-1.51.5-1.51.4-1.41.40.9
Glucose0.20.30.6-0.50.2-0.70.6-0.60.6-0.70.6-0.60.60.4
Heart weight0.10.21.80.0-1.4-0.10.1-0.10.10.0-0.00.0-0.3-0.3
Delay discount hyperbolic model param0.10.10.2-0.5-0.1-0.50.4-0.40.4-0.30.3-0.3-0.20.1
Intermittent access intake day 1-15 change1.21.25.2-1.8-2.3-1.30.7-0.70.6-0.50.5-0.50.2-0.8
Intermittent access intake escalation1.31.34.9-1.9-2.2-1.10.6-0.50.5-0.30.3-0.30.1-1.9
Intermittent access intake escalation 21.71.76.8-2.6-1.5-0.3-0.40.4-0.50.6-0.60.6-1.1-2.6
Intermitt. access day 1 inactive lever presses0.20.20.60.50.30.8-0.30.3-0.30.4-0.40.4-0.7-0.0
Intermitt. access day 15 inactive lever presses1.01.13.0-1.6-1.2-1.20.9-0.90.8-0.80.8-0.80.0-1.7
Intermitt. access escalation Index0.30.32.2-0.1-0.7-0.30.0-0.10.1-0.20.2-0.20.7-1.5
Intermittent access day 1 total infusions7.99.115.4-3.7-3.9-3.33.0-3.02.9-2.92.9-2.92.6-1.6
Intermittent access day 15 total infusions6.16.817.3-4.1-4.2-3.02.2-2.12.0-1.91.9-1.91.5-2.4
Intermittent access terminal intake (last 3 days)4.75.112.3-3.5-3.5-2.71.9-1.81.8-1.61.6-1.61.6-2.1
Intermittent access total infusions6.87.614.8-3.8-3.8-3.12.5-2.52.5-2.32.3-2.31.9-2.4
Intermittent access day 1 locomotion7.57.815.0-3.8-3.9-2.82.6-2.52.5-2.32.3-2.32.0-3.1
Intermittent access day 15 total locomotion4.85.28.8-2.8-3.0-2.52.2-2.22.1-2.01.9-1.91.3-2.6
Intermittent access total locomotion8.39.518.1-3.6-4.3-3.43.1-3.13.1-3.03.0-3.02.3-1.3
Intermittent access standard deviation1.61.75.6-2.4-2.3-1.40.7-0.70.7-0.60.6-0.60.1-1.8
Left kidney weight1.02.75.3-1.2-0.21.2-1.51.6-1.61.7-1.71.7-2.3-2.2
Right kidney weight1.02.76.1-1.8-0.31.5-1.71.7-1.71.6-1.71.7-2.5-1.3
Cocaine induced anxiety0.80.91.6-1.20.50.7-1.01.0-1.00.9-0.90.9-1.11.3
Post-drug Anxiety1.31.42.6-1.00.91.0-1.41.3-1.31.3-1.31.3-1.6-0.0
Baseline Anxiety1.81.913.43.72.31.1-0.30.3-0.40.4-0.40.40.2-0.6
Tail length0.51.62.2-0.0-0.51.3-1.51.5-1.41.4-1.41.4-1.5-1.4
Length with tail0.51.82.80.3-0.01.6-1.61.6-1.61.7-1.51.5-1.4-0.7
Length without tail0.00.10.9-0.3-0.00.10.0-0.00.00.1-0.00.00.21.0
Times rat made contact with spout0.50.51.10.6-0.4-0.50.8-0.80.8-0.80.7-0.71.00.6
Lifetime Intake7.18.115.2-3.9-3.9-3.22.7-2.72.6-2.52.5-2.52.1-1.9
Liver weight, left0.40.74.22.01.50.30.2-0.20.2-0.10.2-0.20.70.5
Liver weight, right0.91.59.63.12.11.0-0.40.5-0.50.5-0.50.50.10.5
Locomotor activity1.11.83.0-0.4-0.8-1.41.6-1.51.5-1.41.4-1.41.70.7
Locomotor testing distance1.72.95.30.8-0.8-1.61.9-1.91.9-1.71.8-1.82.31.8
Locomotor testing rearing1.01.62.5-0.6-1.4-1.61.5-1.41.4-1.21.2-1.21.40.8
Locomotion in novel chamber0.70.95.52.31.30.40.1-0.20.2-0.30.3-0.30.41.3
Locomotion in novel chamber post-restriction2.32.75.82.11.6-0.91.6-1.51.5-1.51.5-1.52.41.5
Fecal boli incidents, locomotor time 10.60.72.9-1.7-0.9-0.4-0.40.3-0.30.2-0.10.1-0.7-1.6
Change in fecal boli incidents, locomotor task2.42.28.52.92.01.8-1.01.1-1.11.0-1.21.2-0.41.2
Time >=10cm from walls, locomotor time 10.20.20.6-0.30.80.5-0.50.5-0.50.5-0.50.50.0-0.5
Bouts of movement, locomotor time 12.52.85.72.41.71.9-1.61.6-1.61.8-1.51.5-1.40.7
Total resting periods, locomotor time 12.12.33.41.71.41.8-1.61.6-1.61.7-1.51.5-1.40.7
Rest time, locomotor task time 10.30.40.9-0.2-0.90.6-0.50.6-0.60.7-0.70.7-0.70.2
Distance moved, locomotor task time 10.00.10.3-0.30.3-0.0-0.10.1-0.10.0-0.10.1-0.6-0.1
Vertical activity count, locomotor time 10.20.20.90.90.60.4-0.20.2-0.20.1-0.20.20.10.9
Time >=10cm from walls, locomotor time 20.70.75.9-2.4-1.1-0.40.10.0-0.0-0.0-0.20.2-0.40.9
Bouts of movement, locomotor time 22.22.33.61.71.21.9-1.41.5-1.61.7-1.81.8-1.30.0
Total resting periods, locomotor time 23.03.25.82.41.72.2-1.61.7-1.81.9-1.91.9-1.30.3
Rest time, locomotor task time 20.81.03.61.90.31.1-0.60.7-0.81.0-1.01.0-0.21.1
Distance moved, locomotor task time 20.40.52.1-1.4-0.3-0.40.6-0.70.7-0.90.7-0.7-0.20.4
Vertical activity count, locomotor time 21.11.22.0-1.2-0.8-1.21.1-1.11.1-1.41.2-1.20.30.6
Light reinforcement 12.44.46.4-0.9-1.7-1.92.2-2.32.3-2.52.3-2.32.51.4
Light reinforcement 20.10.10.70.80.6-0.0-0.30.3-0.30.2-0.20.20.1-0.3
Bone: marrow area3.26.911.10.51.62.7-3.03.0-3.03.0-3.03.0-3.3-0.9
Bone: maximum diameter2.44.55.60.61.22.0-2.42.4-2.42.3-2.32.3-2.4-2.2
Bone: maximum force4.37.310.01.21.72.7-3.13.1-3.13.1-3.03.0-3.2-1.4
Bone: maximum moment3.96.89.21.11.62.6-3.03.0-3.03.0-2.92.9-3.0-1.3
Mean time between licks in bursts0.30.42.0-1.4-0.4-0.70.3-0.30.3-0.30.3-0.30.3-1.2
Mean num. licks in bursts0.30.31.30.40.2-0.00.5-0.50.5-0.50.5-0.50.91.2
Cd content in liver7.27.99.6-2.5-3.1-3.02.9-3.03.0-2.93.1-3.12.70.8
Co content in liver0.20.21.9-0.2-0.2-0.4-0.10.1-0.10.1-0.20.2-0.1-1.4
Cu content in liver0.60.86.5-0.8-0.5-0.60.2-0.20.2-0.30.3-0.30.0-2.6
Fe content in liver0.30.30.6-0.8-0.00.5-0.60.6-0.60.5-0.60.6-0.8-0.1
K content in liver0.40.41.70.30.40.5-0.50.5-0.60.6-0.60.6-0.5-1.3
Mg content in liver0.60.63.10.30.30.4-0.70.7-0.70.7-0.70.7-0.7-1.8
Mn content in liver0.91.02.81.71.20.8-0.70.8-0.80.9-0.90.9-0.7-1.4
Na content in liver0.20.20.30.10.10.6-0.40.5-0.50.4-0.50.5-0.4-0.4
Rb content in liver1.92.33.3-0.7-1.0-1.71.7-1.71.7-1.81.7-1.71.80.4
Se content in liver0.30.42.3-0.1-0.7-0.40.4-0.40.4-0.40.4-0.40.3-1.5
Sr content in liver0.20.20.6-0.30.8-0.10.4-0.40.4-0.40.4-0.40.40.5
Zn content in liver0.50.65.5-0.7-0.4-0.30.0-0.00.0-0.1-0.00.0-0.2-2.3
Bone: minimum diameter1.83.44.70.70.61.8-2.12.1-2.12.0-2.02.0-2.2-1.8
Time in familiar zone, hab. session 13.93.65.2-1.8-2.3-2.12.0-2.02.0-2.02.0-2.01.7-0.3
Time in novel zone, hab. session 18.17.918.73.24.32.9-2.72.7-2.72.7-2.72.7-2.1-0.9
Total zone transitions, hab. session 15.47.610.0-0.5-2.3-3.13.1-3.13.1-3.13.2-3.23.10.6
Total locomotion distance, hab. session 11.92.73.6-0.5-1.0-1.81.8-1.81.8-1.91.9-1.91.90.9
Locomotion velocity, hab. session 12.73.84.8-1.4-2.0-2.22.0-2.12.1-2.12.1-2.11.91.3
Time in familiar zone, hab. session 22.22.34.6-1.3-0.41.0-1.61.6-1.61.6-1.51.5-2.1-1.6
Time in novel zone, hab. session 21.11.12.20.5-0.0-0.71.1-1.11.1-1.21.1-1.11.41.5
Total zone transitions, hab. session 20.91.22.10.0-1.2-1.41.1-1.11.1-1.21.2-1.21.0-0.0
Total locomotion distance, hab. session 21.41.82.6-0.9-1.6-1.61.3-1.41.4-1.51.5-1.51.20.8
Locomotion velocity, hab. session 21.41.92.8-1.1-1.7-1.61.3-1.41.4-1.51.5-1.51.11.0
Novel to familiar place preference ratio1.92.04.1-0.1-0.4-1.31.6-1.61.6-1.71.6-1.62.00.5
Novelty place preference1.01.12.3-0.2-0.2-0.91.2-1.21.1-1.31.1-1.11.50.5
Time in novel zone, NPP test0.80.82.0-0.0-0.2-0.81.0-1.01.0-1.11.0-1.01.40.4
Total zone transitions, NPP test1.52.23.00.0-1.6-1.71.4-1.51.5-1.61.7-1.71.61.1
Total locomotion distance, NPP test0.40.51.4-0.1-0.8-0.60.5-0.60.6-0.70.7-0.70.61.2
Locomotion velocity, NPP test0.50.71.9-0.3-0.9-0.80.7-0.80.8-0.90.9-0.90.81.4
Intraocular pressure1.41.93.41.21.81.5-1.31.4-1.41.4-1.51.5-1.3-0.9
Delta distance traveled before/after self-admin0.30.30.8-0.20.90.4-0.50.5-0.50.6-0.50.5-0.5-0.4
Delta ambulatory time before/after self-admin0.30.31.70.71.30.5-0.50.5-0.50.5-0.40.4-0.3-0.0
Parametrial fat weight0.20.42.4-1.1-1.6-0.30.1-0.10.1-0.30.2-0.20.1-0.8
Pavlov. Cond. lever latency0.30.31.9-1.4-0.50.0-0.30.4-0.40.4-0.50.5-0.5-0.5
Pavlov. Cond. magazine entry latency0.81.07.12.71.10.9-0.60.5-0.50.5-0.50.5-0.00.5
Pavlov. Cond. change in total contacts0.60.65.42.31.10.4-0.10.1-0.10.1-0.20.20.2-0.1
Pavlov. Cond. index score0.40.63.81.90.60.00.4-0.40.4-0.50.5-0.50.70.4
Pavlov. Cond. latency score0.50.64.12.00.70.10.3-0.40.4-0.50.5-0.50.70.5
Pavlov. Cond. lever contacts0.30.31.01.00.2-0.10.3-0.40.4-0.40.5-0.50.41.0
Pavlov. Cond. magazine entry number0.20.32.7-1.6-0.4-0.2-0.10.1-0.10.2-0.20.2-0.4-0.2
Pavlov. Cond. intertrial magazine entries4.45.39.5-3.1-2.4-2.72.3-2.32.3-2.32.3-2.32.0-0.1
Pavlov. Cond. lever-magazine prob. diff.0.40.53.92.00.60.00.3-0.40.4-0.40.5-0.50.70.3
Pavlov. Cond. response bias0.30.32.51.60.30.5-0.20.2-0.10.1-0.00.00.10.8
Pavlov. Cond. lever latency0.50.71.0-0.4-1.0-1.00.9-0.90.9-0.80.9-0.90.8-0.0
Pavlov. Cond. magazine entry latency0.10.10.70.1-0.10.2-0.10.1-0.10.1-0.10.10.00.9
Pavlov. Cond. change in total contacts0.10.21.00.91.00.30.1-0.10.1-0.10.1-0.10.30.2
Pavlov. Cond. index score0.40.51.31.01.10.8-0.60.6-0.60.6-0.60.6-0.40.4
Pavlov. Cond. latency score0.20.20.40.50.70.6-0.40.4-0.40.4-0.40.4-0.30.4
Pavlov. Cond. lever contacts0.71.02.20.81.51.2-1.01.0-1.00.9-1.01.0-0.80.5
Pavlov. Cond. magazine entry number0.20.30.40.40.50.4-0.60.6-0.60.6-0.60.6-0.5-0.3
Pavlov. Cond. intertrial magazine entries0.20.30.4-0.3-0.6-0.60.6-0.50.5-0.60.5-0.50.60.3
Pavlov. Cond. lever-magazine prob. diff.0.40.61.51.21.20.9-0.60.6-0.60.5-0.60.6-0.30.4
Pavlov. Cond. response bias0.60.82.51.11.61.0-0.70.7-0.70.6-0.70.7-0.50.7
Time in closed arm before self-admin5.15.87.02.52.22.7-2.52.5-2.52.4-2.52.5-2.12.1
Time in closed arm after self-admin3.23.34.21.61.62.1-2.02.0-2.01.9-1.91.9-2.0-0.5
Time in open arm before self-admin0.91.01.3-0.7-0.7-1.11.1-1.11.1-1.01.1-1.10.8-1.0
Time in open arm after self-admin2.93.24.2-1.4-1.3-2.12.1-2.02.0-1.91.9-1.91.90.5
Bone: periosteal estimation3.26.59.40.61.32.5-3.03.0-3.02.9-2.92.9-3.1-1.7
Bone: periosteal perimeter1.93.24.00.51.51.8-2.02.0-2.02.0-2.02.0-1.8-1.6
Bone: post-yield work0.71.01.51.20.81.2-1.11.0-1.01.0-1.01.0-1.00.1
Progressive ratio test 1 active lever presses4.04.19.7-2.7-3.1-2.31.9-1.81.8-1.71.7-1.71.7-1.3
Progressive ratio test 1 breakpoint4.85.011.8-3.1-3.4-2.42.1-2.02.0-1.91.9-1.91.9-0.8
Progressive ratio test 1 inactive lever presses1.21.42.6-1.1-1.6-1.11.3-1.21.2-1.11.1-1.11.30.5
Progressive ratio test 2 active lever presses2.62.86.3-2.5-2.5-2.11.4-1.31.3-1.21.2-1.20.5-2.1
Progressive ratio test 2 breakpoint2.12.44.9-2.2-2.1-2.01.3-1.31.3-1.21.2-1.20.7-1.7
Progressive ratio test 2 inactive lever presses2.12.46.9-2.2-1.4-1.81.3-1.21.2-1.01.0-1.01.0-2.6
Incentive Sensitization - Responses0.50.61.40.5-0.6-1.20.8-0.80.8-0.80.8-0.80.60.0
Incentive Sensitization - Breakpoint0.50.51.30.5-0.5-1.10.7-0.70.7-0.70.7-0.70.6-0.1
Sum of active levers in priming session hrs 5-63.43.313.4-3.7-3.3-1.70.9-0.90.8-0.70.8-0.8-0.0-2.2
Progressive ratio1.41.64.82.21.61.3-0.90.9-0.90.8-0.90.9-0.71.6
Food seeking constrained by brief footshock2.12.69.4-0.9-0.81.1-1.71.7-1.71.5-1.61.6-3.10.0
Seeking ratio, punishment vs. effort1.62.012.2-3.5-2.1-0.6-0.20.2-0.20.2-0.20.2-1.4-1.7
Retroperitoneal fat weight0.41.43.2-1.3-1.10.7-1.21.2-1.21.1-1.21.2-1.80.2
Reaction time number correct9.513.735.4-5.8-5.9-4.03.1-3.13.1-3.03.0-3.01.6-2.5
Reaction time mean minus median0.40.52.71.61.00.7-0.30.3-0.30.1-0.30.30.0-0.9
Reaction time mean minus median AUC0.70.81.61.11.31.2-0.80.8-0.80.6-0.70.7-0.4-1.3
Reaction time num false alarms1.62.14.30.1-0.7-1.31.6-1.61.6-1.61.7-1.72.11.0
Reaction time num false alarms AUC1.72.35.20.6-0.4-1.31.6-1.71.7-1.61.7-1.72.31.3
Reaction time trials correct on left9.513.735.4-5.8-5.9-4.03.1-3.13.1-3.03.0-3.01.6-2.5
Reaction time trials on left9.814.036.0-5.9-6.0-4.03.2-3.23.2-3.13.1-3.11.7-2.4
Reaction time mean0.40.62.10.61.40.6-0.60.6-0.60.6-0.60.6-0.7-1.0
Reaction time mean AUC1.01.32.10.31.41.0-1.11.1-1.11.1-1.21.2-1.3-1.3
Median of all reaction times0.40.62.30.31.50.5-0.60.7-0.70.7-0.70.7-0.8-0.9
Reaction time omissions1.82.43.6-1.9-1.9-1.71.5-1.51.5-1.61.6-1.61.4-0.2
Reaction time false alarm rate1.72.410.93.32.91.1-0.40.4-0.40.4-0.30.30.92.0
Reaction time premature initiation rate0.20.32.21.50.40.10.1-0.10.1-0.20.2-0.20.10.9
Reaction time premature initiations3.04.29.6-1.9-3.1-2.32.0-2.02.1-2.12.1-2.11.3-0.5
Std. dev. reaction times0.10.21.70.20.2-0.10.2-0.20.2-0.30.2-0.20.2-1.3
Reaction time trials completed9.814.036.0-5.9-6.0-4.03.2-3.23.2-3.13.1-3.11.7-2.4
Reaction time trials AUC9.413.633.9-5.5-5.8-4.03.2-3.23.2-3.13.1-3.11.8-2.5
Run reversals in cocaine runway, females2.12.010.4-3.2-1.5-1.51.0-1.01.0-0.90.9-0.90.51.1
Run reversals in cocaine runway, males2.22.14.5-0.5-0.2-1.21.7-1.71.7-1.61.6-1.62.10.7
Latency to leave start box in cocaine runway0.40.51.30.51.10.7-0.60.6-0.60.6-0.70.7-0.7-0.4
Latency to leave start box in cocaine runway, F0.50.51.20.70.60.6-0.60.7-0.70.6-0.80.8-1.1-0.3
Latency to leave start box in cocaine runway, M0.70.72.3-1.50.2-0.60.7-0.70.7-0.80.7-0.71.1-0.1
Std. dev. time between licks in bursts2.12.59.9-3.1-2.8-1.70.9-1.01.0-0.91.0-1.00.5-1.0
Total sessions with >9 infusions2.83.19.2-2.5-3.0-1.91.6-1.61.6-1.51.5-1.50.9-0.6
Short access day 1 total inactive lever presses2.32.63.7-1.0-1.2-1.71.9-1.91.8-1.71.7-1.71.90.7
Short access day 10 total inactive lever presses0.60.71.50.71.21.0-0.80.8-0.80.7-0.70.7-1.20.2
Short access day 1 total infusions14.014.923.3-4.6-4.8-4.44.0-3.93.9-3.83.8-3.82.9-0.4
Short access day 10 total infusions4.75.27.3-2.7-2.6-2.62.4-2.42.4-2.32.3-2.31.9-0.7
Short access total infusions6.97.711.8-3.2-3.4-3.12.9-2.92.9-2.72.7-2.72.4-0.9
Short access day 1 locomotion6.46.98.6-1.5-2.7-2.92.9-2.92.9-2.82.9-2.92.60.9
Short access day 10 total locomotion4.04.410.9-2.6-3.3-2.12.1-2.02.0-2.02.0-2.01.4-0.8
Short access total locomotion6.16.313.3-2.7-3.6-2.72.6-2.62.5-2.42.5-2.51.9-0.7
One hour access (0.3 mA shock)1.82.28.0-2.6-2.8-1.50.8-0.90.9-0.90.9-0.90.8-1.1
Compulsive drug intake1.41.42.5-0.6-0.60.9-1.61.5-1.41.2-1.21.2-1.3-1.0
One hour access (shock baseline)1.31.54.0-1.8-2.0-1.31.1-1.11.1-0.90.9-0.90.9-0.9
Social response proportion3.43.76.0-1.1-2.4-2.12.1-2.12.1-2.12.0-2.01.81.1
Social responses6.28.014.6-3.2-3.8-3.22.9-2.92.9-2.82.8-2.82.20.2
Social time1.41.82.6-0.3-1.1-1.51.6-1.61.6-1.51.5-1.51.50.1
Soleus weight0.72.23.30.2-1.6-1.51.6-1.61.6-1.71.6-1.61.80.1
Bone: stiffness3.75.87.81.71.92.5-2.72.7-2.72.8-2.62.6-2.6-0.7
Tibialis anterior weight0.62.05.9-1.6-2.4-1.61.3-1.31.3-1.11.2-1.20.8-1.1
Time to tail flick, vehicle, before self-admin0.90.91.6-1.0-0.9-1.31.0-1.01.0-1.01.0-1.00.60.5
Time to tail flick, vehicle, after self-admin0.10.10.5-0.30.70.2-0.20.2-0.20.1-0.20.2-0.4-0.1
Time to tail flick, test, before self-admin0.10.10.6-0.0-0.8-0.60.1-0.10.10.10.1-0.1-0.3-0.2
Time to tail flick, test, after self-admin0.40.41.60.20.50.5-0.50.5-0.50.7-0.60.6-0.61.3
Delta time to tail flick, vehicle, before/after SA0.10.10.60.80.70.3-0.10.1-0.10.1-0.10.10.4-0.3
Delta time to tail flick, test, before/after SA0.50.41.4-0.30.80.9-0.50.5-0.50.4-0.50.5-0.21.2
Tibia length3.18.711.61.72.93.1-3.33.3-3.33.3-3.13.1-3.4-1.1
Ambulatory time before self-admin1.61.78.7-3.0-1.5-0.90.7-0.70.8-0.90.8-0.80.0-1.6
Ambulatory time after self-admin0.91.05.4-2.10.90.1-0.20.2-0.20.1-0.20.2-0.5-2.3
Bone: tissue strength0.20.20.70.80.40.3-0.30.2-0.20.3-0.20.2-0.00.6
Total heroin consumption1.72.03.7-0.4-1.9-1.61.5-1.51.5-1.31.5-1.51.60.3
Bone: trabecular number0.40.60.9-0.20.20.8-0.90.9-0.90.9-0.90.9-0.90.8
Bone: trabecular spacing5.06.58.4-1.5-2.6-2.92.7-2.82.8-2.82.8-2.82.7-0.4
Bone: trabecular thickness0.70.91.20.2-0.01.0-1.11.1-1.11.0-1.11.1-1.00.8
Bone: trabecular tissue density0.20.31.0-0.5-0.00.0-0.60.5-0.50.5-0.40.4-0.6-1.0
Water consumed over 24 hours0.70.93.31.81.21.1-0.70.7-0.70.7-0.70.7-0.30.6
Number of responses in last shaping day0.70.71.8-1.2-1.3-0.70.8-0.80.8-0.80.8-0.80.6-0.8