Hub : Genes

Thra

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Thra 0.08 0.05 2.8e-03 0.02 0 0 0 3.8e-02 2.4e-01 3.1e-01 2.6e-01
2 NAcc mRNA stability Thra 0.02 0.01 3.9e-04 0.02 0.02 0.01 0.02 1.2e-04 7.4e-04 3.7e-03 7.7e-04
3 Adipose alternative polyA NM_001017960.2 0.03 0.03 1.4e-03 0.01 0.01 0.01 0.01 1.7e-02 1.9e-02 4.5e-02 2.3e-02
4 Adipose alternative polyA NM_031134.2 0.03 0.03 2.2e-03 0.01 0.01 0.01 0.01 2.6e-02 3.1e-02 6.7e-02 3.9e-02
5 Brain gene expression Thra 0.08 0.04 1.2e-07 0.08 0.08 0.08 0.08 1.5e-07 6.5e-08 4.0e-08 1.1e-07
6 PL mRNA stability Thra 0.22 0.17 2.8e-05 0.04 0.04 0.04 0.04 7.1e-05 2.8e-05 8.5e-05 8.6e-05
7 Liver gene expression Thra 0.03 0.02 1.6e-03 0 0.01 0.01 0 7.5e-02 3.4e-02 2.7e-02 1.3e-01
8 PL intron excision ratio chr10_84221103_84224936 0.05 0.03 9.6e-04 0.02 0.02 0.02 0.02 5.6e-03 1.7e-03 3.4e-03 5.2e-03
9 PL intron excision ratio chr10_84221103_84224819 0.05 0.04 7.0e-04 0.01 0.02 0.02 0.02 4.0e-02 1.1e-03 5.0e-03 4.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.34.05.42.1-2.02.0-2.02.2-1.42.3-2.02.0
Area under the delay curve0.20.30.70.8-0.70.5-0.50.4-0.20.5-0.20.2
BMI with tail1.75.912.2-2.82.6-2.62.6-2.23.5-2.70.7-0.4
BMI without tail0.72.23.9-1.71.4-1.81.8-1.21.9-2.00.2-0.1
Body weight4.620.330.6-5.45.2-4.94.9-4.45.5-4.72.0-1.7
Weight adjusted by age0.40.72.0-0.71.3-0.10.1-0.01.40.7-0.80.8
Bone surface0.20.41.20.5-0.40.2-0.20.60.10.3-1.01.1
Bone volume0.51.02.70.7-0.70.5-0.51.10.10.9-1.61.6
Breakpoint value in progressive ratio session0.10.20.7-0.40.80.1-0.1-0.2-0.30.7-0.20.1
Number of licking bursts0.30.51.50.3-0.30.6-0.60.80.40.5-1.21.2
Context. condit. distance diff. score2.32.85.5-1.21.3-1.81.8-1.80.6-1.22.3-2.3
Locomotion velocity, session 10.30.30.7-0.40.8-0.70.7-0.60.7-0.60.1-0.1
Locomotion distance, session 11.62.03.8-1.31.7-1.71.7-1.21.4-2.00.3-0.2
Locomotion velocity, session 20.10.10.3-0.20.3-0.30.3-0.40.1-0.50.4-0.4
Locomotion distance, session 20.20.31.0-0.00.3-0.10.10.20.4-0.4-0.91.0
Locomotion velocity, session 30.00.00.1-0.0-0.10.1-0.10.1-0.4-0.10.3-0.3
Locomotion distance, session 30.20.30.5-0.70.7-0.40.4-0.40.6-0.60.2-0.1
Stereotopy head waving bouts, day 31.92.23.92.0-1.81.6-1.61.4-1.81.3-0.70.6
Stereotopy head waving duration, day 30.20.20.60.8-0.70.3-0.30.3-0.60.1-0.10.1
Locomotion velocity, session 70.80.92.3-0.81.2-0.90.9-0.71.5-1.10.1-0.1
Locomotion distance, session 70.40.50.9-0.30.9-0.80.8-0.60.8-0.90.3-0.3
Stereotopy head waving bouts, day 70.60.71.01.0-0.80.8-0.81.0-0.11.0-0.80.8
Stereotopy head waving duration, day 70.20.30.50.5-0.50.6-0.60.60.00.7-0.50.6
Locomotion velocity, session 87.38.811.2-2.93.1-3.33.3-3.22.4-3.02.6-2.6
Locomotion distance, session 81.21.72.7-1.31.4-1.71.7-1.31.1-1.41.0-0.9
Degree of sensitization distance0.91.01.4-0.60.8-1.21.2-1.10.6-1.11.0-1.0
Degree of sensitization stereotypy0.70.81.30.9-0.80.8-0.81.00.21.1-1.01.0
Conditioned locomotion0.20.20.50.5-0.40.5-0.50.4-0.40.7-0.0-0.0
Cocaine response after cond. corrected1.01.32.81.4-0.60.9-0.91.30.20.7-1.61.7
Cocaine response after cond. not corrected1.11.32.91.5-0.50.9-0.91.30.30.8-1.71.7
Cocaine response before conditioning0.00.00.10.30.1-0.00.0-0.1-0.20.00.2-0.3
Saline control response0.50.61.7-0.30.8-0.90.9-0.61.3-0.80.3-0.2
Bone: connectivity density3.25.06.32.5-2.42.3-2.32.4-1.92.3-2.01.9
Bone: cortical apparent density3.95.39.92.8-2.42.4-2.42.0-3.12.8-0.70.5
Bone: cortical area0.10.10.80.3-0.20.3-0.30.40.10.9-0.20.2
Bone: cortical porosity0.60.71.30.8-0.60.5-0.50.90.30.9-1.11.1
Bone: cortical porosity0.40.41.00.6-0.20.1-0.10.60.70.5-1.01.0
Bone: cortical thickness0.61.13.01.2-0.91.1-1.11.0-0.91.7-0.30.2
Bone: cortical thickness3.84.57.42.3-2.32.3-2.32.1-2.32.7-1.21.1
Bone: cortical tissue density3.95.410.02.8-2.42.4-2.42.0-3.22.8-0.70.5
Condit. Reinf. active minus inactive responses0.91.01.91.0-0.91.2-1.20.9-1.41.1-0.30.2
Condit. Reinf. active-inactive response ratio1.01.12.31.0-0.81.4-1.40.8-1.51.20.0-0.1
Condit. Reinf. active responses0.81.01.61.0-0.91.2-1.21.0-1.31.1-0.40.3
Condit. Reinf. inactive responses0.10.20.40.3-0.30.3-0.30.50.10.4-0.70.7
Incentive salience index mean1.92.33.01.6-1.61.7-1.71.6-1.71.7-0.90.8
Condit. Reinf. lever presses1.41.92.61.5-1.51.3-1.31.6-1.21.6-1.21.1
Condit. Reinf. active minus inactive responses1.11.42.00.8-1.01.3-1.31.2-1.01.4-1.31.2
Condit. Reinf. active-inactive response ratio1.21.42.10.8-1.11.2-1.21.3-0.81.2-1.41.4
Condit. Reinf. active responses1.82.63.41.2-1.41.7-1.71.6-1.11.8-1.81.8
Condit. Reinf. inactive responses1.62.12.41.5-1.31.5-1.51.5-1.01.5-1.61.5
Condit. Reinf. lever presses0.10.10.20.3-0.20.5-0.50.2-0.30.3-0.10.1
Condit. Reinf. lever reinforcers received1.92.63.61.3-1.41.8-1.81.6-1.31.9-1.71.6
Conditioned reinforcement - actives0.00.00.1-0.10.30.3-0.3-0.10.1-0.20.1-0.1
Conditioned reinforcement - inactives0.20.31.60.4-0.70.4-0.40.3-1.30.20.1-0.2
Conditioned locomotion0.40.51.00.7-0.11.0-1.00.6-0.30.1-0.90.8
Patch foraging indifference point 0 sec1.12.14.02.0-1.61.6-1.61.3-2.01.2-0.50.4
Patch foraging indifference point AUC0.00.00.30.10.1-0.20.20.00.50.2-0.10.1
Delay disc. indifference point, 0s delay1.51.73.11.8-1.31.3-1.31.3-1.21.3-1.00.9
Delay disc. indifference point, 16s delay0.40.41.00.6-0.70.1-0.10.0-0.61.00.8-0.8
Delay disc. indifference point, 2s delay1.01.12.01.4-0.60.9-0.91.2-0.30.7-1.41.3
Delay disc. indifference point, 24s delay0.20.20.5-0.3-0.0-0.40.4-0.50.5-0.40.7-0.7
Delay disc. indifference point, 4s delay1.01.01.71.1-0.91.1-1.11.0-0.51.3-0.90.9
Delay disc. indifference point, 8s delay0.10.10.40.4-0.70.3-0.30.30.2-0.0-0.20.2
Indifference point function ln k0.10.20.8-0.00.0-0.10.1-0.4-0.2-0.30.9-0.9
Indifference point function log k0.10.20.8-0.00.0-0.10.1-0.4-0.2-0.30.9-0.9
Patch foraging total patch changes 0 sec0.71.32.91.7-1.31.2-1.21.0-1.60.8-0.30.2
Patch foraging total patch changes 12 sec4.25.56.62.5-2.42.4-2.42.6-2.02.3-2.32.2
Patch foraging total patch changes 18 sec0.20.30.40.6-0.50.6-0.60.6-0.30.6-0.40.4
Patch foraging total patch changes 24 sec0.50.91.91.2-0.51.1-1.10.9-0.41.4-0.80.8
Patch foraging total patch changes 6 sec1.42.13.61.9-1.71.4-1.41.5-1.71.4-0.90.8
Patch foraging time to switch 0 sec0.10.10.30.2-0.20.4-0.40.4-0.30.3-0.50.5
Patch foraging water rate 0 sec0.10.20.40.4-0.60.4-0.40.2-0.60.2-0.00.0
Patch foraging water rate 12 sec0.10.20.6-0.80.60.1-0.1-0.40.00.10.4-0.5
Patch foraging water rate 18 sec0.60.91.60.7-0.71.0-1.01.1-0.41.3-1.01.0
Patch foraging water rate 24 sec0.60.81.90.7-1.30.8-0.80.8-1.40.7-0.50.4
Patch foraging water rate 6 sec1.72.53.01.6-1.71.7-1.71.7-1.61.6-1.21.2
Seeking ratio, delayed vs. immediate footshock0.50.61.70.30.7-0.10.1-0.5-1.00.31.2-1.3
Distance traveled before self-admin0.20.30.80.1-0.20.4-0.40.6-0.30.9-0.80.8
Distance traveled after self-admin0.20.20.5-0.70.1-0.60.6-0.40.4-0.50.2-0.2
Extensor digitorum longus weight8.834.440.6-6.26.4-6.16.1-6.35.4-6.25.1-4.9
Bone: elastic displacement0.00.00.10.20.2-0.20.2-0.1-0.1-0.30.2-0.2
Bone: elastic work0.10.20.40.5-0.20.2-0.20.5-0.10.6-0.60.6
Bone: endosteal estimation1.43.05.4-2.01.7-2.02.0-1.52.3-2.00.3-0.2
Bone: endosteal perimeter0.81.83.3-1.81.2-1.61.6-1.31.5-1.30.6-0.5
Epididymis fat weight0.10.41.3-0.51.0-0.50.5-0.31.1-0.3-0.30.4
Delta time in closed arm before/after self-admin3.63.45.0-1.92.1-2.22.2-1.91.9-1.21.3-1.2
Delta time in open arm before/after self-admin0.00.00.1-0.1-0.1-0.00.00.0-0.10.30.3-0.3
Diff in mean of infusions in LGA sessions0.10.10.2-0.30.30.2-0.20.0-0.20.3-0.50.4
Delay discount exponential model param0.10.10.4-0.60.6-0.30.3-0.30.1-0.30.1-0.1
Extinction: sum of active levers before priming1.21.33.2-1.21.1-1.31.3-1.11.8-0.90.7-0.6
Active lever presses in extinction session 61.71.75.01.0-0.60.7-0.71.40.51.1-2.22.2
Bone: final force0.81.32.41.2-0.90.9-0.91.30.21.4-1.51.6
Bone: final moment0.61.02.01.0-0.80.6-0.61.10.41.2-1.41.4
Food consumed during 24 hour testing period0.60.81.3-1.10.8-1.01.0-0.90.8-1.10.6-0.6
Glucose0.20.20.80.80.1-0.30.30.30.9-0.1-0.40.5
Heart weight2.94.56.5-2.02.5-2.52.5-2.21.6-2.01.7-1.6
Delay discount hyperbolic model param0.10.10.4-0.60.5-0.30.3-0.30.0-0.30.2-0.1
Intermittent access intake day 1-15 change0.10.20.60.1-0.40.5-0.50.3-0.70.8-0.30.3
Intermittent access intake escalation0.10.20.6-0.0-0.40.4-0.40.2-0.70.7-0.20.2
Intermittent access intake escalation 20.10.10.3-0.60.0-0.30.3-0.3-0.1-0.20.1-0.1
Intermitt. access day 1 inactive lever presses0.72.74.41.6-2.01.6-1.61.6-2.02.1-1.00.9
Intermitt. access day 15 inactive lever presses1.02.14.31.4-2.01.7-1.71.3-2.10.9-0.50.4
Intermitt. access escalation Index1.52.14.9-2.11.4-1.51.5-1.32.2-0.60.8-0.7
Intermittent access day 1 total infusions0.00.00.2-0.20.10.0-0.0-0.2-0.40.10.3-0.3
Intermittent access day 15 total infusions0.10.20.6-0.2-0.10.1-0.1-0.2-0.80.60.4-0.5
Intermittent access terminal intake (last 3 days)0.20.31.10.0-0.70.4-0.40.1-1.10.60.1-0.2
Intermittent access total infusions0.10.20.6-0.3-0.10.1-0.1-0.2-0.70.40.5-0.5
Intermittent access day 1 locomotion0.00.00.10.20.20.1-0.1-0.1-0.4-0.20.2-0.3
Intermittent access day 15 total locomotion0.10.30.60.8-0.10.5-0.50.4-0.50.0-0.60.6
Intermittent access total locomotion0.50.61.01.0-0.60.9-0.90.6-1.00.6-0.40.4
Intermittent access standard deviation1.02.25.81.1-1.81.5-1.51.2-2.41.5-0.80.7
Left kidney weight0.21.12.8-1.70.9-1.11.1-1.00.9-0.80.9-0.9
Right kidney weight0.10.30.9-0.2-0.40.1-0.10.50.40.4-0.91.0
Cocaine induced anxiety1.92.65.4-2.31.4-1.81.8-1.52.0-1.70.8-0.7
Post-drug Anxiety0.60.61.6-1.30.6-0.80.8-0.81.0-0.80.6-0.5
Baseline Anxiety1.11.32.51.6-0.81.4-1.41.0-0.81.3-0.70.6
Tail length0.41.42.3-1.21.5-1.21.2-1.30.6-1.11.2-1.2
Length with tail1.67.111.9-3.43.4-2.82.8-2.72.6-2.41.6-1.5
Length without tail2.37.312.1-3.13.5-2.82.8-2.73.2-2.61.4-1.3
Times rat made contact with spout0.91.01.41.1-1.20.9-0.91.2-0.70.9-1.11.1
Lifetime Intake0.20.21.1-0.0-0.20.3-0.3-0.0-1.10.70.4-0.4
Liver weight, left0.20.31.0-0.30.8-0.50.5-0.41.0-0.4-0.10.2
Liver weight, right0.30.51.31.1-1.00.4-0.40.8-0.51.0-0.20.2
Locomotor activity0.81.22.50.8-0.81.0-1.01.2-0.01.0-1.61.6
Locomotor testing distance1.73.03.81.7-1.91.9-1.91.9-1.01.8-1.71.6
Locomotor testing rearing3.77.410.93.2-3.33.0-3.02.7-2.92.7-1.51.4
Locomotion in novel chamber4.05.18.32.9-1.72.3-2.32.5-2.02.6-1.91.8
Locomotion in novel chamber post-restriction0.61.02.50.6-0.90.9-0.91.1-0.40.6-1.51.6
Fecal boli incidents, locomotor time 10.20.20.5-0.20.7-0.50.5-0.50.4-0.70.2-0.2
Change in fecal boli incidents, locomotor task0.10.10.30.5-0.10.1-0.10.20.1-0.4-0.10.0
Time >=10cm from walls, locomotor time 10.10.10.30.50.30.3-0.3-0.0-0.20.20.5-0.5
Bouts of movement, locomotor time 10.30.31.5-1.10.1-0.30.3-0.31.2-0.1-0.10.1
Total resting periods, locomotor time 10.70.72.6-1.40.6-0.70.7-0.71.6-0.50.00.1
Rest time, locomotor task time 10.10.10.3-0.2-0.60.1-0.10.2-0.00.1-0.50.6
Distance moved, locomotor task time 10.10.10.50.40.7-0.20.2-0.2-0.00.30.3-0.3
Vertical activity count, locomotor time 10.20.62.7-0.21.7-0.60.6-0.80.6-0.60.5-0.5
Time >=10cm from walls, locomotor time 20.50.81.41.20.11.2-1.20.9-0.00.9-0.80.7
Bouts of movement, locomotor time 20.30.40.80.3-0.90.9-0.90.6-0.40.9-0.10.0
Total resting periods, locomotor time 20.10.20.50.1-0.60.7-0.70.4-0.30.70.1-0.2
Rest time, locomotor task time 20.40.50.8-0.90.9-0.70.7-0.80.9-0.80.4-0.4
Distance moved, locomotor task time 20.20.20.90.20.9-0.60.6-0.30.6-0.10.2-0.1
Vertical activity count, locomotor time 20.50.72.1-0.31.5-0.80.8-0.90.7-0.80.6-0.6
Light reinforcement 11.74.35.22.0-2.32.2-2.22.2-2.12.1-1.81.7
Light reinforcement 20.61.01.71.3-1.00.5-0.51.2-0.60.7-1.31.3
Bone: marrow area1.32.84.9-1.91.6-2.02.0-1.42.2-1.90.4-0.2
Bone: maximum diameter0.10.20.5-0.2-0.30.3-0.30.40.20.7-0.60.6
Bone: maximum force0.10.10.60.00.1-0.30.30.10.80.1-0.40.5
Bone: maximum moment0.10.20.9-0.10.2-0.50.5-0.10.9-0.1-0.30.3
Mean time between licks in bursts0.61.52.7-1.61.2-1.41.4-1.11.3-1.30.8-0.7
Mean num. licks in bursts0.10.20.80.5-0.50.1-0.10.1-0.90.10.3-0.4
Cd content in liver1.01.11.9-1.41.2-1.31.3-1.20.70.00.8-0.8
Co content in liver1.82.13.1-1.61.4-1.61.6-1.80.50.01.8-1.7
Cu content in liver0.10.10.40.20.10.2-0.20.0-0.60.00.4-0.5
Fe content in liver1.01.22.1-1.31.3-1.51.5-1.11.40.00.5-0.4
K content in liver0.70.61.10.8-0.91.1-1.10.9-0.90.0-0.40.4
Mg content in liver0.50.51.20.7-0.80.8-0.80.3-1.10.00.5-0.6
Mn content in liver0.80.92.21.2-1.01.2-1.20.8-1.50.00.1-0.2
Na content in liver0.80.82.60.4-0.50.7-0.71.00.30.0-1.61.6
Rb content in liver1.11.33.41.8-1.51.1-1.11.2-1.40.0-0.50.4
Se content in liver5.66.69.92.8-3.03.1-3.12.8-3.00.0-1.81.6
Sr content in liver0.50.51.4-0.60.5-0.20.2-0.7-0.50.01.1-1.2
Zn content in liver2.83.15.11.9-2.12.0-2.01.9-2.30.0-1.21.1
Bone: minimum diameter0.30.61.6-0.80.8-1.01.0-0.61.3-0.40.3-0.2
Time in familiar zone, hab. session 10.50.51.70.5-0.50.3-0.30.8-0.0-0.0-1.31.3
Time in novel zone, hab. session 10.40.40.90.9-0.30.6-0.60.1-1.00.50.6-0.7
Total zone transitions, hab. session 11.82.53.3-1.51.7-1.81.8-1.80.9-1.81.4-1.4
Total locomotion distance, hab. session 10.10.20.4-0.20.3-0.20.2-0.4-0.6-0.40.5-0.5
Locomotion velocity, hab. session 10.30.51.0-1.00.8-0.60.6-0.80.0-0.50.7-0.7
Time in familiar zone, hab. session 20.60.71.10.7-0.70.7-0.70.9-0.60.8-1.01.0
Time in novel zone, hab. session 20.10.10.20.4-0.20.5-0.50.2-0.40.40.1-0.1
Total zone transitions, hab. session 21.01.32.0-0.61.4-1.31.3-1.21.1-1.40.7-0.7
Total locomotion distance, hab. session 20.20.30.6-0.50.8-0.60.6-0.50.4-0.7-0.00.1
Locomotion velocity, hab. session 20.40.51.0-0.81.0-0.80.8-0.80.7-0.90.2-0.1
Novel to familiar place preference ratio1.11.22.6-1.61.0-0.80.8-1.21.0-1.01.2-1.2
Novelty place preference1.21.32.5-1.60.9-0.80.8-1.20.8-1.01.3-1.4
Time in novel zone, NPP test0.60.61.4-1.20.7-0.40.4-0.80.6-0.61.0-1.0
Total zone transitions, NPP test0.40.61.2-0.51.0-1.11.1-0.60.9-0.9-0.10.2
Total locomotion distance, NPP test0.10.10.30.10.2-0.40.40.00.0-0.4-0.50.5
Locomotion velocity, NPP test0.30.40.9-0.60.4-0.90.9-0.50.3-0.90.1-0.1
Intraocular pressure2.94.17.7-2.11.7-2.22.2-2.11.7-2.81.6-1.5
Delta distance traveled before/after self-admin1.41.51.9-1.01.1-1.21.2-1.31.0-1.41.2-1.2
Delta ambulatory time before/after self-admin1.21.52.9-1.10.9-1.31.3-1.21.7-1.60.8-0.7
Parametrial fat weight0.71.73.60.8-1.21.2-1.21.5-0.60.9-1.91.9
Pavlov. Cond. lever latency2.83.55.3-1.91.9-1.71.7-2.10.9-1.52.3-2.3
Pavlov. Cond. magazine entry latency9.612.315.03.4-3.73.6-3.63.8-2.83.9-3.43.3
Pavlov. Cond. change in total contacts7.88.311.43.0-3.43.1-3.13.0-3.13.1-1.91.7
Pavlov. Cond. index score8.410.612.93.3-3.43.3-3.33.6-2.43.3-3.33.2
Pavlov. Cond. latency score6.68.310.42.9-3.02.9-2.93.2-2.02.8-3.13.0
Pavlov. Cond. lever contacts3.74.46.32.0-2.22.0-2.02.4-1.11.8-2.52.5
Pavlov. Cond. magazine entry number11.314.317.8-4.04.2-3.93.9-4.13.3-4.13.2-3.1
Pavlov. Cond. intertrial magazine entries1.51.72.7-0.91.6-1.21.2-1.40.9-1.71.4-1.4
Pavlov. Cond. lever-magazine prob. diff.9.812.114.73.6-3.73.5-3.53.8-2.83.6-3.43.3
Pavlov. Cond. response bias9.611.814.33.5-3.83.5-3.53.7-2.93.8-3.02.9
Pavlov. Cond. lever latency0.50.70.9-0.50.8-0.90.9-0.80.6-0.81.0-0.9
Pavlov. Cond. magazine entry latency0.10.10.2-0.50.5-0.20.2-0.30.3-0.1-0.10.1
Pavlov. Cond. change in total contacts0.40.61.40.8-0.90.9-0.90.7-1.20.6-0.40.3
Pavlov. Cond. index score0.20.20.40.2-0.40.5-0.50.4-0.30.2-0.70.6
Pavlov. Cond. latency score0.10.10.30.1-0.30.3-0.30.3-0.20.1-0.50.5
Pavlov. Cond. lever contacts0.60.81.20.7-0.90.9-0.90.9-0.50.7-1.11.1
Pavlov. Cond. magazine entry number0.10.10.2-0.20.1-0.30.3-0.20.2-0.20.4-0.4
Pavlov. Cond. intertrial magazine entries1.72.53.9-1.71.5-1.41.4-1.80.8-1.41.9-2.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.1-0.30.3-0.30.3-0.20.1-0.50.5
Pavlov. Cond. response bias1.01.41.90.9-1.11.3-1.31.2-0.81.3-1.41.3
Time in closed arm before self-admin1.62.16.31.6-2.51.3-1.31.2-2.10.7-0.20.1
Time in closed arm after self-admin0.60.62.0-0.4-0.2-0.50.5-0.8-0.50.11.4-1.4
Time in open arm before self-admin1.41.55.4-1.22.3-1.11.1-1.11.6-0.50.4-0.4
Time in open arm after self-admin0.20.20.7-0.40.9-0.50.5-0.40.4-0.10.2-0.2
Bone: periosteal estimation0.20.41.3-0.70.5-0.70.7-0.31.2-0.3-0.30.4
Bone: periosteal perimeter0.40.71.7-1.20.8-1.01.0-0.61.3-0.5-0.10.1
Bone: post-yield work1.11.62.2-1.51.0-1.51.5-1.31.1-1.41.1-1.0
Progressive ratio test 1 active lever presses0.00.00.1-0.0-0.10.2-0.20.10.20.30.1-0.1
Progressive ratio test 1 breakpoint0.00.00.1-0.1-0.10.1-0.1-0.00.30.10.2-0.2
Progressive ratio test 1 inactive lever presses0.20.30.80.2-0.80.5-0.50.3-0.90.80.1-0.1
Progressive ratio test 2 active lever presses0.70.81.30.8-0.71.1-1.10.8-1.21.1-0.60.5
Progressive ratio test 2 breakpoint0.80.91.30.9-0.81.1-1.10.8-1.21.1-0.70.6
Progressive ratio test 2 inactive lever presses0.10.21.10.2-0.30.4-0.40.2-1.10.3-0.10.1
Incentive Sensitization - Responses1.21.73.31.4-1.11.4-1.41.3-1.81.1-1.21.1
Incentive Sensitization - Breakpoint1.21.62.91.4-1.11.3-1.31.2-1.71.1-1.11.1
Sum of active levers in priming session hrs 5-60.20.20.40.50.10.0-0.00.30.40.6-0.50.5
Progressive ratio0.20.30.40.60.20.4-0.40.50.20.7-0.70.6
Food seeking constrained by brief footshock0.60.71.60.7-1.30.7-0.71.1-0.3-0.1-1.01.0
Seeking ratio, punishment vs. effort0.10.20.4-0.4-0.6-0.20.2-0.2-0.0-0.70.4-0.3
Retroperitoneal fat weight0.00.20.60.8-0.50.3-0.30.5-0.50.1-0.40.4
Reaction time number correct0.40.91.6-1.31.2-1.11.1-0.91.0-0.50.5-0.4
Reaction time mean minus median0.20.61.5-0.90.8-0.60.6-0.90.6-1.20.5-0.5
Reaction time mean minus median AUC0.00.10.3-0.30.2-0.10.1-0.30.4-0.50.1-0.1
Reaction time num false alarms0.60.81.60.9-0.70.6-0.60.9-0.31.2-1.31.3
Reaction time num false alarms AUC0.50.71.60.6-0.60.6-0.60.8-0.20.9-1.31.3
Reaction time trials correct on left0.40.91.6-1.31.2-1.11.1-0.91.0-0.50.5-0.4
Reaction time trials on left0.40.81.5-1.21.2-1.01.0-0.90.9-0.50.4-0.4
Reaction time mean0.20.30.9-0.2-0.40.7-0.70.1-0.90.50.1-0.1
Reaction time mean AUC0.20.30.9-0.1-0.40.7-0.70.1-1.00.60.1-0.2
Median of all reaction times0.81.12.60.4-1.11.3-1.30.7-1.61.3-0.30.2
Reaction time omissions0.30.51.10.4-0.70.7-0.70.6-1.10.7-0.60.5
Reaction time false alarm rate1.01.41.81.2-1.21.1-1.11.2-0.71.2-1.41.3
Reaction time premature initiation rate0.50.72.20.3-0.30.9-0.90.7-0.21.5-0.90.9
Reaction time premature initiations0.10.20.6-0.70.6-0.00.0-0.10.50.8-0.30.3
Std. dev. reaction times0.00.00.1-0.40.20.1-0.1-0.3-0.1-0.3-0.00.0
Reaction time trials completed0.40.81.5-1.21.2-1.01.0-0.90.9-0.50.4-0.4
Reaction time trials AUC0.40.81.5-1.21.2-1.01.0-0.90.9-0.50.6-0.5
Run reversals in cocaine runway, females2.72.74.7-1.71.7-1.41.4-2.00.6-0.82.2-2.2
Run reversals in cocaine runway, males0.20.20.30.6-0.40.3-0.30.5-0.40.1-0.30.3
Latency to leave start box in cocaine runway1.31.52.2-0.81.5-1.41.4-1.20.3-0.91.4-1.4
Latency to leave start box in cocaine runway, F1.61.93.1-1.41.8-1.51.5-1.41.0-0.81.3-1.3
Latency to leave start box in cocaine runway, M0.30.31.50.8-0.20.1-0.10.2-1.2-0.10.4-0.5
Std. dev. time between licks in bursts0.10.10.4-0.70.1-0.00.0-0.00.4-0.0-0.30.4
Total sessions with >9 infusions0.30.41.20.3-0.40.3-0.3-0.1-1.10.60.8-0.9
Short access day 1 total inactive lever presses1.52.05.71.7-1.41.3-1.31.3-2.41.2-0.60.6
Short access day 10 total inactive lever presses0.00.10.8-0.1-0.10.3-0.3-0.0-0.9-0.0-0.10.0
Short access day 1 total infusions0.40.61.70.8-0.60.5-0.50.3-1.31.10.7-0.7
Short access day 10 total infusions0.30.40.90.3-0.90.6-0.60.4-0.90.9-0.10.0
Short access total infusions0.30.41.40.4-0.50.6-0.60.3-1.21.10.2-0.3
Short access day 1 locomotion0.91.12.81.3-1.40.9-0.90.9-1.71.2-0.10.0
Short access day 10 total locomotion0.91.62.91.7-1.51.3-1.31.2-1.20.6-1.21.2
Short access total locomotion0.30.31.20.9-0.60.4-0.40.3-1.10.20.1-0.1
One hour access (0.3 mA shock)0.40.40.9-0.81.0-0.30.3-0.80.6-0.50.7-0.7
Compulsive drug intake0.81.03.2-0.50.5-0.30.3-1.00.3-0.81.8-1.8
One hour access (shock baseline)0.00.00.2-0.20.00.1-0.10.1-0.10.4-0.20.2
Social response proportion0.40.40.7-0.10.8-0.90.9-0.50.8-0.60.5-0.5
Social responses0.20.20.70.8-0.30.0-0.00.60.1-0.2-0.70.7
Social time0.30.41.5-0.30.1-0.10.10.30.7-0.5-1.11.2
Soleus weight0.20.61.80.30.2-0.10.10.41.3-0.5-1.21.3
Bone: stiffness0.00.10.2-0.2-0.1-0.10.10.10.50.4-0.30.3
Tibialis anterior weight1.34.46.6-2.32.3-2.32.3-2.02.3-2.61.2-1.1
Time to tail flick, vehicle, before self-admin0.20.20.80.1-0.60.0-0.00.1-0.4-0.9-0.40.5
Time to tail flick, vehicle, after self-admin0.30.41.1-0.00.30.5-0.50.40.8-0.3-1.11.1
Time to tail flick, test, before self-admin1.01.12.7-1.31.0-0.90.9-0.91.6-1.30.3-0.2
Time to tail flick, test, after self-admin0.30.30.90.6-0.6-0.00.00.6-0.4-0.2-0.90.9
Delta time to tail flick, vehicle, before/after SA1.11.02.80.5-0.30.8-0.81.00.70.7-1.71.7
Delta time to tail flick, test, before/after SA2.22.34.42.1-1.61.2-1.21.6-2.11.3-1.11.1
Tibia length1.33.57.2-1.91.9-2.32.3-1.52.7-2.00.6-0.4
Ambulatory time before self-admin0.10.10.3-0.2-0.30.3-0.30.2-0.50.5-0.30.3
Ambulatory time after self-admin0.80.91.9-1.40.4-1.11.1-0.91.1-1.20.3-0.2
Bone: tissue strength1.51.62.2-1.21.2-1.31.3-1.31.2-1.51.1-1.1
Total heroin consumption3.23.76.71.6-1.11.8-1.82.0-1.51.8-2.62.6
Bone: trabecular number5.69.211.23.3-3.03.0-3.03.3-2.13.3-3.03.0
Bone: trabecular spacing1.52.03.6-1.81.5-1.61.6-1.21.9-1.50.4-0.3
Bone: trabecular thickness0.10.20.20.4-0.40.3-0.30.4-0.40.4-0.40.4
Bone: trabecular tissue density0.50.82.7-0.30.6-0.30.3-0.9-0.3-0.61.6-1.6
Water consumed over 24 hours0.10.10.4-0.30.2-0.40.4-0.20.3-0.60.00.0
Number of responses in last shaping day0.50.52.50.5-0.80.4-0.40.1-1.60.10.7-0.7