Hub : Genes

Thra

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Thra 0.08 0.05 2.8e-03 0.02 0 0 0 3.8e-02 2.4e-01 3.1e-01 2.7e-01
2 NAcc mRNA stability Thra 0.02 0.01 3.9e-04 0.02 0.02 0.01 0.02 1.2e-04 7.4e-04 3.7e-03 7.1e-04
3 Adipose alternative polyA NM_001017960.2 0.03 0.03 1.4e-03 0.01 0.01 0.01 0.01 1.7e-02 1.9e-02 4.5e-02 2.2e-02
4 Adipose alternative polyA NM_031134.2 0.03 0.03 2.2e-03 0.01 0.01 0.01 0.01 2.6e-02 3.1e-02 6.7e-02 4.0e-02
5 Brain gene expression Thra 0.08 0.04 1.2e-07 0.08 0.08 0.08 0.08 1.5e-07 6.5e-08 4.0e-08 1.1e-07
6 PL mRNA stability Thra 0.22 0.17 2.8e-05 0.04 0.04 0.04 0.04 7.1e-05 2.8e-05 8.5e-05 9.2e-05
7 Liver gene expression Thra 0.03 0.02 1.6e-03 0 0.01 0.01 0 7.5e-02 3.4e-02 2.7e-02 1.3e-01
8 PL intron excision ratio chr10_84221103_84224936 0.05 0.03 9.6e-04 0.02 0.02 0.02 0.02 5.6e-03 1.7e-03 3.4e-03 4.5e-03
9 PL intron excision ratio chr10_84221103_84224819 0.05 0.04 7.0e-04 0.01 0.02 0.02 0.02 4.0e-02 1.1e-03 5.0e-03 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.24.05.4-2.12.0-2.02.0-2.2-1.4-2.3-2.02.0
Area under the delay curve0.20.30.7-0.80.7-0.50.5-0.4-0.2-0.5-0.20.2
BMI with tail1.75.912.22.8-2.62.6-2.62.23.52.70.7-0.4
BMI without tail0.42.23.91.7-1.41.8-1.81.21.92.00.2-0.1
Body weight4.620.330.65.4-5.24.9-4.94.45.54.72.0-1.7
Weight adjusted by age0.20.72.00.7-1.30.1-0.10.01.4-0.7-0.80.8
Bone surface0.20.41.2-0.50.4-0.20.2-0.60.1-0.3-1.01.1
Bone volume0.51.02.7-0.70.7-0.50.5-1.10.1-0.9-1.61.6
Breakpoint value in progressive ratio session0.10.20.70.4-0.8-0.10.10.2-0.3-0.7-0.20.1
Number of licking bursts0.20.51.5-0.30.3-0.60.6-0.80.4-0.5-1.21.2
Context. condit. distance diff. score2.32.85.51.2-1.31.8-1.81.80.61.22.3-2.3
Locomotion velocity, session 10.30.30.70.4-0.80.7-0.70.60.70.60.1-0.1
Locomotion distance, session 11.52.03.81.3-1.71.7-1.71.21.42.00.3-0.2
Locomotion velocity, session 20.10.10.30.2-0.30.3-0.30.40.10.50.4-0.4
Locomotion distance, session 20.20.31.00.0-0.30.1-0.1-0.20.40.4-0.91.0
Locomotion velocity, session 30.00.00.10.00.1-0.10.1-0.1-0.40.10.3-0.3
Locomotion distance, session 30.20.30.50.7-0.70.4-0.40.40.60.60.2-0.1
Stereotopy head waving bouts, day 31.92.23.9-2.01.8-1.61.6-1.4-1.8-1.3-0.70.6
Stereotopy head waving duration, day 30.20.20.6-0.80.7-0.30.3-0.3-0.6-0.1-0.10.1
Locomotion velocity, session 70.80.92.30.8-1.20.9-0.90.71.51.10.1-0.1
Locomotion distance, session 70.40.50.90.3-0.90.8-0.80.60.80.90.3-0.3
Stereotopy head waving bouts, day 70.60.71.0-1.00.8-0.80.8-1.0-0.1-1.0-0.80.8
Stereotopy head waving duration, day 70.20.30.5-0.50.5-0.60.6-0.60.0-0.7-0.50.6
Locomotion velocity, session 87.28.811.22.9-3.13.3-3.33.22.43.02.6-2.6
Locomotion distance, session 81.21.72.71.3-1.41.7-1.71.31.11.41.0-0.9
Degree of sensitization distance0.91.01.40.6-0.81.2-1.21.10.61.11.0-1.0
Degree of sensitization stereotypy0.70.81.3-0.90.8-0.80.8-1.00.2-1.1-1.01.0
Conditioned locomotion0.20.20.5-0.50.4-0.50.5-0.4-0.4-0.7-0.0-0.0
Cocaine response after cond. corrected0.81.32.8-1.40.6-0.90.9-1.30.2-0.7-1.61.7
Cocaine response after cond. not corrected0.91.32.9-1.50.5-0.90.9-1.30.3-0.8-1.71.7
Cocaine response before conditioning0.00.00.1-0.3-0.10.0-0.00.1-0.2-0.00.2-0.3
Saline control response0.40.61.70.3-0.80.9-0.90.61.30.80.3-0.2
Bone: connectivity density3.15.06.3-2.52.4-2.32.3-2.4-1.9-2.3-2.01.9
Bone: cortical apparent density3.45.39.9-2.82.4-2.42.4-2.0-3.1-2.8-0.70.5
Bone: cortical area0.10.10.8-0.30.2-0.30.3-0.40.1-0.9-0.20.2
Bone: cortical porosity0.60.71.3-0.80.6-0.50.5-0.90.3-0.9-1.11.1
Bone: cortical porosity0.40.41.0-0.60.2-0.10.1-0.60.7-0.5-1.01.0
Bone: cortical thickness0.61.13.0-1.20.9-1.11.1-1.0-0.9-1.7-0.30.2
Bone: cortical thickness3.74.57.4-2.32.3-2.32.3-2.1-2.3-2.7-1.21.1
Bone: cortical tissue density3.45.410.0-2.82.4-2.42.4-2.0-3.2-2.8-0.70.5
Condit. Reinf. active minus inactive responses0.91.01.9-1.00.9-1.21.2-0.9-1.4-1.1-0.30.2
Condit. Reinf. active-inactive response ratio1.01.12.3-1.00.8-1.41.4-0.8-1.5-1.20.0-0.1
Condit. Reinf. active responses0.81.01.6-1.00.9-1.21.2-1.0-1.3-1.1-0.40.3
Condit. Reinf. inactive responses0.10.20.4-0.30.3-0.30.3-0.50.1-0.4-0.70.7
Incentive salience index mean1.82.33.0-1.61.6-1.71.7-1.6-1.7-1.7-0.90.8
Condit. Reinf. lever presses1.31.92.6-1.51.5-1.31.3-1.6-1.2-1.6-1.21.1
Condit. Reinf. active minus inactive responses0.91.42.0-0.81.0-1.31.3-1.2-1.0-1.4-1.31.2
Condit. Reinf. active-inactive response ratio0.91.42.1-0.81.1-1.21.2-1.3-0.8-1.2-1.41.4
Condit. Reinf. active responses1.82.63.4-1.21.4-1.71.7-1.6-1.1-1.8-1.81.8
Condit. Reinf. inactive responses1.42.12.4-1.51.3-1.51.5-1.5-1.0-1.5-1.61.5
Condit. Reinf. lever presses0.10.10.2-0.30.2-0.50.5-0.2-0.3-0.3-0.10.1
Condit. Reinf. lever reinforcers received1.82.63.6-1.31.4-1.81.8-1.6-1.3-1.9-1.71.6
Conditioned reinforcement - actives0.00.00.10.1-0.3-0.30.30.10.10.20.1-0.1
Conditioned reinforcement - inactives0.10.31.6-0.40.7-0.40.4-0.3-1.3-0.20.1-0.2
Conditioned locomotion0.30.51.0-0.70.1-1.01.0-0.6-0.3-0.1-0.90.8
Patch foraging indifference point 0 sec0.72.14.0-2.01.6-1.61.6-1.3-2.0-1.2-0.50.4
Patch foraging indifference point AUC0.00.00.3-0.1-0.10.2-0.2-0.00.5-0.2-0.10.1
Delay disc. indifference point, 0s delay1.51.73.1-1.81.3-1.31.3-1.3-1.2-1.3-1.00.9
Delay disc. indifference point, 16s delay0.30.41.0-0.60.7-0.10.1-0.0-0.6-1.00.8-0.8
Delay disc. indifference point, 2s delay1.01.12.0-1.40.6-0.90.9-1.2-0.3-0.7-1.41.3
Delay disc. indifference point, 24s delay0.10.20.50.30.00.4-0.40.50.50.40.7-0.7
Delay disc. indifference point, 4s delay1.01.01.7-1.10.9-1.11.1-1.0-0.5-1.3-0.90.9
Delay disc. indifference point, 8s delay0.10.10.4-0.40.7-0.30.3-0.30.20.0-0.20.2
Indifference point function ln k0.10.20.80.0-0.00.1-0.10.4-0.20.30.9-0.9
Indifference point function log k0.10.20.80.0-0.00.1-0.10.4-0.20.30.9-0.9
Patch foraging total patch changes 0 sec0.51.32.9-1.71.3-1.21.2-1.0-1.6-0.8-0.30.2
Patch foraging total patch changes 12 sec4.15.56.6-2.52.4-2.42.4-2.6-2.0-2.3-2.32.2
Patch foraging total patch changes 18 sec0.10.30.4-0.60.5-0.60.6-0.6-0.3-0.6-0.40.4
Patch foraging total patch changes 24 sec0.30.91.9-1.20.5-1.11.1-0.9-0.4-1.4-0.80.8
Patch foraging total patch changes 6 sec1.22.13.6-1.91.7-1.41.4-1.5-1.7-1.4-0.90.8
Patch foraging time to switch 0 sec0.00.10.3-0.20.2-0.40.4-0.4-0.3-0.3-0.50.5
Patch foraging water rate 0 sec0.00.20.4-0.40.6-0.40.4-0.2-0.6-0.2-0.00.0
Patch foraging water rate 12 sec0.00.20.60.8-0.6-0.10.10.40.0-0.10.4-0.5
Patch foraging water rate 18 sec0.40.91.6-0.70.7-1.01.0-1.1-0.4-1.3-1.01.0
Patch foraging water rate 24 sec0.60.81.9-0.71.3-0.80.8-0.8-1.4-0.7-0.50.4
Patch foraging water rate 6 sec1.72.53.0-1.61.7-1.71.7-1.7-1.6-1.6-1.21.2
Seeking ratio, delayed vs. immediate footshock0.40.61.7-0.3-0.70.1-0.10.5-1.0-0.31.2-1.3
Distance traveled before self-admin0.10.30.8-0.10.2-0.40.4-0.6-0.3-0.9-0.80.8
Distance traveled after self-admin0.10.20.50.7-0.10.6-0.60.40.40.50.2-0.2
Extensor digitorum longus weight8.634.440.66.2-6.46.1-6.16.35.46.25.1-4.9
Bone: elastic displacement0.00.00.1-0.2-0.20.2-0.20.1-0.10.30.2-0.2
Bone: elastic work0.10.20.4-0.50.2-0.20.2-0.5-0.1-0.6-0.60.6
Bone: endosteal estimation1.23.05.42.0-1.72.0-2.01.52.32.00.3-0.2
Bone: endosteal perimeter0.71.83.31.8-1.21.6-1.61.31.51.30.6-0.5
Epididymis fat weight0.10.41.30.5-1.00.5-0.50.31.10.3-0.30.4
Delta time in closed arm before/after self-admin3.63.45.01.9-2.12.2-2.21.91.91.21.3-1.2
Delta time in open arm before/after self-admin0.00.00.10.10.10.0-0.0-0.0-0.1-0.30.3-0.3
Diff in mean of infusions in LGA sessions0.00.10.20.3-0.3-0.20.2-0.0-0.2-0.3-0.50.4
Delay discount exponential model param0.10.10.40.6-0.60.3-0.30.30.10.30.1-0.1
Extinction: sum of active levers before priming0.91.33.21.2-1.11.3-1.31.11.80.90.7-0.6
Active lever presses in extinction session 61.71.75.0-1.00.6-0.70.7-1.40.5-1.1-2.22.2
Bone: final force0.81.32.4-1.20.9-0.90.9-1.30.2-1.4-1.51.6
Bone: final moment0.61.02.0-1.00.8-0.60.6-1.10.4-1.2-1.41.4
Food consumed during 24 hour testing period0.40.81.31.1-0.81.0-1.00.90.81.10.6-0.6
Glucose0.20.20.8-0.8-0.10.3-0.3-0.30.90.1-0.40.5
Heart weight2.84.56.52.0-2.52.5-2.52.21.62.01.7-1.6
Delay discount hyperbolic model param0.10.10.40.6-0.50.3-0.30.30.00.30.2-0.1
Intermittent access intake day 1-15 change0.00.20.6-0.10.4-0.50.5-0.3-0.7-0.8-0.30.3
Intermittent access intake escalation0.00.20.60.00.4-0.40.4-0.2-0.7-0.7-0.20.2
Intermittent access intake escalation 20.00.10.30.6-0.00.3-0.30.3-0.10.20.1-0.1
Intermitt. access day 1 inactive lever presses0.22.74.4-1.62.0-1.61.6-1.6-2.0-2.1-1.00.9
Intermitt. access day 15 inactive lever presses0.42.14.3-1.42.0-1.71.7-1.3-2.1-0.9-0.50.4
Intermitt. access escalation Index0.72.14.92.1-1.41.5-1.51.32.20.60.8-0.7
Intermittent access day 1 total infusions0.00.00.20.2-0.1-0.00.00.2-0.4-0.10.3-0.3
Intermittent access day 15 total infusions0.10.20.60.20.1-0.10.10.2-0.8-0.60.4-0.5
Intermittent access terminal intake (last 3 days)0.10.31.1-0.00.7-0.40.4-0.1-1.1-0.60.1-0.2
Intermittent access total infusions0.10.20.60.30.1-0.10.10.2-0.7-0.40.5-0.5
Intermittent access day 1 locomotion0.00.00.1-0.2-0.2-0.10.10.1-0.40.20.2-0.3
Intermittent access day 15 total locomotion0.10.30.6-0.80.1-0.50.5-0.4-0.5-0.0-0.60.6
Intermittent access total locomotion0.50.61.0-1.00.6-0.90.9-0.6-1.0-0.6-0.40.4
Intermittent access standard deviation0.42.25.8-1.11.8-1.51.5-1.2-2.4-1.5-0.80.7
Left kidney weight0.11.12.81.7-0.91.1-1.11.00.90.80.9-0.9
Right kidney weight0.00.30.90.20.4-0.10.1-0.50.4-0.4-0.91.0
Cocaine induced anxiety1.02.65.42.3-1.41.8-1.81.52.01.70.8-0.7
Post-drug Anxiety0.60.61.61.3-0.60.8-0.80.81.00.80.6-0.5
Baseline Anxiety0.81.32.5-1.60.8-1.41.4-1.0-0.8-1.3-0.70.6
Tail length0.31.42.31.2-1.51.2-1.21.30.61.11.2-1.2
Length with tail1.67.111.93.4-3.42.8-2.82.72.62.41.6-1.5
Length without tail1.47.312.13.1-3.52.8-2.82.73.22.61.4-1.3
Times rat made contact with spout0.91.01.4-1.11.2-0.90.9-1.2-0.7-0.9-1.11.1
Lifetime Intake0.20.21.10.00.2-0.30.30.0-1.1-0.70.4-0.4
Liver weight, left0.20.31.00.3-0.80.5-0.50.41.00.4-0.10.2
Liver weight, right0.30.51.3-1.11.0-0.40.4-0.8-0.5-1.0-0.20.2
Locomotor activity0.81.22.5-0.80.8-1.01.0-1.2-0.0-1.0-1.61.6
Locomotor testing distance1.23.03.8-1.71.9-1.91.9-1.9-1.0-1.8-1.71.6
Locomotor testing rearing2.07.410.9-3.23.3-3.03.0-2.7-2.9-2.7-1.51.4
Locomotion in novel chamber3.85.18.3-2.91.7-2.32.3-2.5-2.0-2.6-1.91.8
Locomotion in novel chamber post-restriction0.31.02.5-0.60.9-0.90.9-1.1-0.4-0.6-1.51.6
Fecal boli incidents, locomotor time 10.10.20.50.2-0.70.5-0.50.50.40.70.2-0.2
Change in fecal boli incidents, locomotor task0.00.10.3-0.50.1-0.10.1-0.20.10.4-0.10.0
Time >=10cm from walls, locomotor time 10.10.10.3-0.5-0.3-0.30.30.0-0.2-0.20.5-0.5
Bouts of movement, locomotor time 10.30.31.51.1-0.10.3-0.30.31.20.1-0.10.1
Total resting periods, locomotor time 10.60.72.61.4-0.60.7-0.70.71.60.50.00.1
Rest time, locomotor task time 10.10.10.30.20.6-0.10.1-0.2-0.0-0.1-0.50.6
Distance moved, locomotor task time 10.00.10.5-0.4-0.70.2-0.20.2-0.0-0.30.3-0.3
Vertical activity count, locomotor time 10.10.62.70.2-1.70.6-0.60.80.60.60.5-0.5
Time >=10cm from walls, locomotor time 20.30.81.4-1.2-0.1-1.21.2-0.9-0.0-0.9-0.80.7
Bouts of movement, locomotor time 20.10.40.8-0.30.9-0.90.9-0.6-0.4-0.9-0.10.0
Total resting periods, locomotor time 20.10.20.5-0.10.6-0.70.7-0.4-0.3-0.70.1-0.2
Rest time, locomotor task time 20.30.50.80.9-0.90.7-0.70.80.90.80.4-0.4
Distance moved, locomotor task time 20.20.20.9-0.2-0.90.6-0.60.30.60.10.2-0.1
Vertical activity count, locomotor time 20.30.72.10.3-1.50.8-0.80.90.70.80.6-0.6
Light reinforcement 10.94.35.2-2.02.3-2.22.2-2.2-2.1-2.1-1.81.7
Light reinforcement 20.41.01.7-1.31.0-0.50.5-1.2-0.6-0.7-1.31.3
Bone: marrow area1.12.84.91.9-1.62.0-2.01.42.21.90.4-0.2
Bone: maximum diameter0.10.20.50.20.3-0.30.3-0.40.2-0.7-0.60.6
Bone: maximum force0.10.10.6-0.0-0.10.3-0.3-0.10.8-0.1-0.40.5
Bone: maximum moment0.10.20.90.1-0.20.5-0.50.10.90.1-0.30.3
Mean time between licks in bursts0.31.52.71.6-1.21.4-1.41.11.31.30.8-0.7
Mean num. licks in bursts0.10.20.8-0.50.5-0.10.1-0.1-0.9-0.10.3-0.4
Cd content in liver1.01.11.91.4-1.21.3-1.31.20.70.00.8-0.8
Co content in liver1.82.13.11.6-1.41.6-1.61.80.50.01.8-1.7
Cu content in liver0.10.10.4-0.2-0.1-0.20.2-0.0-0.60.00.4-0.5
Fe content in liver1.01.22.11.3-1.31.5-1.51.11.40.00.5-0.4
K content in liver0.60.61.1-0.80.9-1.11.1-0.9-0.90.0-0.40.4
Mg content in liver0.40.51.2-0.70.8-0.80.8-0.3-1.10.00.5-0.6
Mn content in liver0.80.92.2-1.21.0-1.21.2-0.8-1.50.00.1-0.2
Na content in liver0.70.82.6-0.40.5-0.70.7-1.00.30.0-1.61.6
Rb content in liver1.11.33.4-1.81.5-1.11.1-1.2-1.40.0-0.50.4
Se content in liver5.66.69.9-2.83.0-3.13.1-2.8-3.00.0-1.81.6
Sr content in liver0.50.51.40.6-0.50.2-0.20.7-0.50.01.1-1.2
Zn content in liver2.63.15.1-1.92.1-2.02.0-1.9-2.30.0-1.21.1
Bone: minimum diameter0.30.61.60.8-0.81.0-1.00.61.30.40.3-0.2
Time in familiar zone, hab. session 10.50.51.7-0.50.5-0.30.3-0.8-0.00.0-1.31.3
Time in novel zone, hab. session 10.40.40.9-0.90.3-0.60.6-0.1-1.0-0.50.6-0.7
Total zone transitions, hab. session 11.82.53.31.5-1.71.8-1.81.80.91.81.4-1.4
Total locomotion distance, hab. session 10.10.20.40.2-0.30.2-0.20.4-0.60.40.5-0.5
Locomotion velocity, hab. session 10.30.51.01.0-0.80.6-0.60.80.00.50.7-0.7
Time in familiar zone, hab. session 20.60.71.1-0.70.7-0.70.7-0.9-0.6-0.8-1.01.0
Time in novel zone, hab. session 20.10.10.2-0.40.2-0.50.5-0.2-0.4-0.40.1-0.1
Total zone transitions, hab. session 21.01.32.00.6-1.41.3-1.31.21.11.40.7-0.7
Total locomotion distance, hab. session 20.20.30.60.5-0.80.6-0.60.50.40.7-0.00.1
Locomotion velocity, hab. session 20.40.51.00.8-1.00.8-0.80.80.70.90.2-0.1
Novel to familiar place preference ratio0.91.22.61.6-1.00.8-0.81.21.01.01.2-1.2
Novelty place preference1.01.32.51.6-0.90.8-0.81.20.81.01.3-1.4
Time in novel zone, NPP test0.50.61.41.2-0.70.4-0.40.80.60.61.0-1.0
Total zone transitions, NPP test0.40.61.20.5-1.01.1-1.10.60.90.9-0.10.2
Total locomotion distance, NPP test0.10.10.3-0.1-0.20.4-0.4-0.00.00.4-0.50.5
Locomotion velocity, NPP test0.30.40.90.6-0.40.9-0.90.50.30.90.1-0.1
Intraocular pressure2.54.17.72.1-1.72.2-2.22.11.72.81.6-1.5
Delta distance traveled before/after self-admin1.31.51.91.0-1.11.2-1.21.31.01.41.2-1.2
Delta ambulatory time before/after self-admin0.91.52.91.1-0.91.3-1.31.21.71.60.8-0.7
Parametrial fat weight0.71.73.6-0.81.2-1.21.2-1.5-0.6-0.9-1.91.9
Pavlov. Cond. lever latency2.73.55.31.9-1.91.7-1.72.10.91.52.3-2.3
Pavlov. Cond. magazine entry latency9.612.315.0-3.43.7-3.63.6-3.8-2.8-3.9-3.43.3
Pavlov. Cond. change in total contacts7.78.311.4-3.03.4-3.13.1-3.0-3.1-3.1-1.91.7
Pavlov. Cond. index score8.310.612.9-3.33.4-3.33.3-3.6-2.4-3.3-3.33.2
Pavlov. Cond. latency score6.68.310.4-2.93.0-2.92.9-3.2-2.0-2.8-3.13.0
Pavlov. Cond. lever contacts3.64.46.3-2.02.2-2.02.0-2.4-1.1-1.8-2.52.5
Pavlov. Cond. magazine entry number11.214.317.84.0-4.23.9-3.94.13.34.13.2-3.1
Pavlov. Cond. intertrial magazine entries1.51.72.70.9-1.61.2-1.21.40.91.71.4-1.4
Pavlov. Cond. lever-magazine prob. diff.9.812.114.7-3.63.7-3.53.5-3.8-2.8-3.6-3.43.3
Pavlov. Cond. response bias9.511.814.3-3.53.8-3.53.5-3.7-2.9-3.8-3.02.9
Pavlov. Cond. lever latency0.50.70.90.5-0.80.9-0.90.80.60.81.0-0.9
Pavlov. Cond. magazine entry latency0.10.10.20.5-0.50.2-0.20.30.30.1-0.10.1
Pavlov. Cond. change in total contacts0.30.61.4-0.80.9-0.90.9-0.7-1.2-0.6-0.40.3
Pavlov. Cond. index score0.10.20.4-0.20.4-0.50.5-0.4-0.3-0.2-0.70.6
Pavlov. Cond. latency score0.10.10.3-0.10.3-0.30.3-0.3-0.2-0.1-0.50.5
Pavlov. Cond. lever contacts0.50.81.2-0.70.9-0.90.9-0.9-0.5-0.7-1.11.1
Pavlov. Cond. magazine entry number0.00.10.20.2-0.10.3-0.30.20.20.20.4-0.4
Pavlov. Cond. intertrial magazine entries1.22.53.91.7-1.51.4-1.41.80.81.41.9-2.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.10.3-0.30.3-0.3-0.2-0.1-0.50.5
Pavlov. Cond. response bias1.01.41.9-0.91.1-1.31.3-1.2-0.8-1.3-1.41.3
Time in closed arm before self-admin1.22.16.3-1.62.5-1.31.3-1.2-2.1-0.7-0.20.1
Time in closed arm after self-admin0.50.62.00.40.20.5-0.50.8-0.5-0.11.4-1.4
Time in open arm before self-admin1.31.55.41.2-2.31.1-1.11.11.60.50.4-0.4
Time in open arm after self-admin0.20.20.70.4-0.90.5-0.50.40.40.10.2-0.2
Bone: periosteal estimation0.20.41.30.7-0.50.7-0.70.31.20.3-0.30.4
Bone: periosteal perimeter0.40.71.71.2-0.81.0-1.00.61.30.5-0.10.1
Bone: post-yield work0.91.62.21.5-1.01.5-1.51.31.11.41.1-1.0
Progressive ratio test 1 active lever presses0.00.00.10.00.1-0.20.2-0.10.2-0.30.1-0.1
Progressive ratio test 1 breakpoint0.00.00.10.10.1-0.10.10.00.3-0.10.2-0.2
Progressive ratio test 1 inactive lever presses0.10.30.8-0.20.8-0.50.5-0.3-0.9-0.80.1-0.1
Progressive ratio test 2 active lever presses0.60.81.3-0.80.7-1.11.1-0.8-1.2-1.1-0.60.5
Progressive ratio test 2 breakpoint0.70.91.3-0.90.8-1.11.1-0.8-1.2-1.1-0.70.6
Progressive ratio test 2 inactive lever presses0.10.21.1-0.20.3-0.40.4-0.2-1.1-0.3-0.10.1
Incentive Sensitization - Responses0.61.73.3-1.41.1-1.41.4-1.3-1.8-1.1-1.21.1
Incentive Sensitization - Breakpoint0.71.62.9-1.41.1-1.31.3-1.2-1.7-1.1-1.11.1
Sum of active levers in priming session hrs 5-60.20.20.4-0.5-0.1-0.00.0-0.30.4-0.6-0.50.5
Progressive ratio0.10.30.4-0.6-0.2-0.40.4-0.50.2-0.7-0.70.6
Food seeking constrained by brief footshock0.60.71.6-0.71.3-0.70.7-1.1-0.30.1-1.01.0
Seeking ratio, punishment vs. effort0.10.20.40.40.60.2-0.20.2-0.00.70.4-0.3
Retroperitoneal fat weight0.00.20.6-0.80.5-0.30.3-0.5-0.5-0.1-0.40.4
Reaction time number correct0.20.91.61.3-1.21.1-1.10.91.00.50.5-0.4
Reaction time mean minus median0.10.61.50.9-0.80.6-0.60.90.61.20.5-0.5
Reaction time mean minus median AUC0.00.10.30.3-0.20.1-0.10.30.40.50.1-0.1
Reaction time num false alarms0.50.81.6-0.90.7-0.60.6-0.9-0.3-1.2-1.31.3
Reaction time num false alarms AUC0.30.71.6-0.60.6-0.60.6-0.8-0.2-0.9-1.31.3
Reaction time trials correct on left0.20.91.61.3-1.21.1-1.10.91.00.50.5-0.4
Reaction time trials on left0.20.81.51.2-1.21.0-1.00.90.90.50.4-0.4
Reaction time mean0.10.30.90.20.4-0.70.7-0.1-0.9-0.50.1-0.1
Reaction time mean AUC0.10.30.90.10.4-0.70.7-0.1-1.0-0.60.1-0.2
Median of all reaction times0.71.12.6-0.41.1-1.31.3-0.7-1.6-1.3-0.30.2
Reaction time omissions0.30.51.1-0.40.7-0.70.7-0.6-1.1-0.7-0.60.5
Reaction time false alarm rate1.01.41.8-1.21.2-1.11.1-1.2-0.7-1.2-1.41.3
Reaction time premature initiation rate0.40.72.2-0.30.3-0.90.9-0.7-0.2-1.5-0.90.9
Reaction time premature initiations0.10.20.60.7-0.60.0-0.00.10.5-0.8-0.30.3
Std. dev. reaction times0.00.00.10.4-0.2-0.10.10.3-0.10.3-0.00.0
Reaction time trials completed0.20.81.51.2-1.21.0-1.00.90.90.50.4-0.4
Reaction time trials AUC0.20.81.51.2-1.21.0-1.00.90.90.50.6-0.5
Run reversals in cocaine runway, females2.42.74.71.7-1.71.4-1.42.00.60.82.2-2.2
Run reversals in cocaine runway, males0.10.20.3-0.60.4-0.30.3-0.5-0.4-0.1-0.30.3
Latency to leave start box in cocaine runway1.11.52.20.8-1.51.4-1.41.20.30.91.4-1.4
Latency to leave start box in cocaine runway, F1.51.93.11.4-1.81.5-1.51.41.00.81.3-1.3
Latency to leave start box in cocaine runway, M0.30.31.5-0.80.2-0.10.1-0.2-1.20.10.4-0.5
Std. dev. time between licks in bursts0.10.10.40.7-0.10.0-0.00.00.40.0-0.30.4
Total sessions with >9 infusions0.30.41.2-0.30.4-0.30.30.1-1.1-0.60.8-0.9
Short access day 1 total inactive lever presses1.02.05.7-1.71.4-1.31.3-1.3-2.4-1.2-0.60.6
Short access day 10 total inactive lever presses0.00.10.80.10.1-0.30.30.0-0.90.0-0.10.0
Short access day 1 total infusions0.30.61.7-0.80.6-0.50.5-0.3-1.3-1.10.7-0.7
Short access day 10 total infusions0.20.40.9-0.30.9-0.60.6-0.4-0.9-0.9-0.10.0
Short access total infusions0.30.41.4-0.40.5-0.60.6-0.3-1.2-1.10.2-0.3
Short access day 1 locomotion0.71.12.8-1.31.4-0.90.9-0.9-1.7-1.2-0.10.0
Short access day 10 total locomotion0.41.62.9-1.71.5-1.31.3-1.2-1.2-0.6-1.21.2
Short access total locomotion0.20.31.2-0.90.6-0.40.4-0.3-1.1-0.20.1-0.1
One hour access (0.3 mA shock)0.40.40.90.8-1.00.3-0.30.80.60.50.7-0.7
Compulsive drug intake0.71.03.20.5-0.50.3-0.31.00.30.81.8-1.8
One hour access (shock baseline)0.00.00.20.2-0.0-0.10.1-0.1-0.1-0.4-0.20.2
Social response proportion0.30.40.70.1-0.80.9-0.90.50.80.60.5-0.5
Social responses0.20.20.7-0.80.3-0.00.0-0.60.10.2-0.70.7
Social time0.30.41.50.3-0.10.1-0.1-0.30.70.5-1.11.2
Soleus weight0.20.61.8-0.3-0.20.1-0.1-0.41.30.5-1.21.3
Bone: stiffness0.00.10.20.20.10.1-0.1-0.10.5-0.4-0.30.3
Tibialis anterior weight1.34.46.62.3-2.32.3-2.32.02.32.61.2-1.1
Time to tail flick, vehicle, before self-admin0.20.20.8-0.10.6-0.00.0-0.1-0.40.9-0.40.5
Time to tail flick, vehicle, after self-admin0.20.41.10.0-0.3-0.50.5-0.40.80.3-1.11.1
Time to tail flick, test, before self-admin0.91.12.71.3-1.00.9-0.90.91.61.30.3-0.2
Time to tail flick, test, after self-admin0.30.30.9-0.60.60.0-0.0-0.6-0.40.2-0.90.9
Delta time to tail flick, vehicle, before/after SA1.01.02.8-0.50.3-0.80.8-1.00.7-0.7-1.71.7
Delta time to tail flick, test, before/after SA1.82.34.4-2.11.6-1.21.2-1.6-2.1-1.3-1.11.1
Tibia length1.33.57.21.9-1.92.3-2.31.52.72.00.6-0.4
Ambulatory time before self-admin0.00.10.30.20.3-0.30.3-0.2-0.5-0.5-0.30.3
Ambulatory time after self-admin0.60.91.91.4-0.41.1-1.10.91.11.20.3-0.2
Bone: tissue strength1.51.62.21.2-1.21.3-1.31.31.21.51.1-1.1
Total heroin consumption3.13.76.7-1.61.1-1.81.8-2.0-1.5-1.8-2.62.6
Bone: trabecular number4.99.211.2-3.33.0-3.03.0-3.3-2.1-3.3-3.03.0
Bone: trabecular spacing1.42.03.61.8-1.51.6-1.61.21.91.50.4-0.3
Bone: trabecular thickness0.10.20.2-0.40.4-0.30.3-0.4-0.4-0.4-0.40.4
Bone: trabecular tissue density0.40.82.70.3-0.60.3-0.30.9-0.30.61.6-1.6
Water consumed over 24 hours0.10.10.40.3-0.20.4-0.40.20.30.60.00.0
Number of responses in last shaping day0.40.52.5-0.50.8-0.40.4-0.1-1.6-0.10.7-0.7