Hub : Genes

Tha1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Tha1 0.04 0.03 2.9e-06 0.04 0.04 0.04 0.04 1.6e-05 1.3e-05 2.0e-05 2.3e-05
2 Brain intron excision ratio chr10_103098301_103099841 0.03 0.03 6.0e-04 0.02 0.03 0.03 0.03 2.2e-03 8.1e-04 6.5e-04 4.2e-04
3 Liver gene expression Tha1 0.05 0.03 2.2e-08 0.06 0.06 0.05 0.06 6.7e-07 3.3e-07 5.4e-06 5.5e-07
4 Adipose gene expression Tha1 0.07 0.05 1.7e-11 0.1 0.09 0.09 0.1 3.2e-11 3.4e-10 7.0e-10 1.2e-10
5 Adipose alternative TSS XM_006247853.4 0.02 0.01 5.1e-03 0.02 0.01 0 0.01 6.1e-03 7.2e-03 7.3e-02 1.1e-02
6 NAcc isoform ratio XM_006247853.4 0.08 0.05 8.9e-04 0.01 0.02 0.02 0.01 5.7e-02 7.2e-04 2.0e-03 1.4e-02
7 NAcc gene expression Tha1 0.08 0.06 5.0e-03 0 0.02 0.01 0.02 1.3e-01 5.3e-03 3.4e-02 5.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.91.52.2-1.41.3-1.31.5-1.3-1.00.5
Area under the delay curve1.31.43.11.0-1.71.2-0.91.6-0.30.7
BMI with tail1.03.110.40.30.6-0.2-0.5-1.33.0-3.2
BMI without tail0.91.83.7-1.41.7-1.51.1-1.90.1-0.4
Body weight0.93.78.01.8-1.51.5-1.70.92.8-2.6
Weight adjusted by age0.00.00.10.1-0.40.1-0.4-0.10.1-0.2
Bone surface0.30.61.10.5-0.80.8-0.61.0-0.80.7
Bone volume0.10.10.6-0.3-0.1-0.10.10.1-0.80.5
Breakpoint value in progressive ratio session0.60.61.8-0.00.3-0.0-0.8-0.81.0-1.3
Number of licking bursts0.00.00.10.2-0.30.2-0.00.40.00.1
Context. condit. distance diff. score0.10.10.50.4-0.10.4-0.70.00.3-0.4
Locomotion velocity, session 10.70.81.90.9-1.20.9-0.31.4-0.20.5
Locomotion distance, session 11.72.23.7-1.81.4-1.91.7-1.5-1.00.8
Locomotion velocity, session 20.40.50.8-0.90.7-0.90.9-0.5-0.60.4
Locomotion distance, session 24.36.09.1-2.92.5-3.03.0-2.4-1.51.0
Locomotion velocity, session 30.40.51.30.2-0.60.30.10.9-0.81.2
Locomotion distance, session 30.20.20.4-0.30.6-0.40.4-0.60.4-0.4
Stereotopy head waving bouts, day 32.02.34.21.6-1.51.6-2.01.11.3-1.3
Stereotopy head waving duration, day 31.82.13.91.5-1.61.6-2.01.21.0-1.0
Locomotion velocity, session 70.30.41.1-0.30.3-0.20.4-0.1-1.01.0
Locomotion distance, session 72.83.55.0-2.22.2-2.12.0-2.1-1.30.9
Stereotopy head waving bouts, day 73.23.65.02.2-2.02.2-2.21.71.4-1.2
Stereotopy head waving duration, day 74.85.88.42.8-2.92.9-2.52.71.3-0.9
Locomotion velocity, session 80.40.50.70.6-0.70.8-0.50.8-0.60.7
Locomotion distance, session 82.23.24.7-2.22.1-2.21.7-2.1-1.00.6
Degree of sensitization distance3.53.54.7-2.21.8-1.91.9-1.5-2.11.7
Degree of sensitization stereotypy1.31.42.11.4-1.31.5-1.31.20.9-0.7
Conditioned locomotion0.10.10.3-0.60.4-0.50.2-0.3-0.20.1
Cocaine response after cond. corrected0.40.50.90.6-0.40.5-0.90.30.9-0.9
Cocaine response after cond. not corrected0.10.10.30.3-0.40.3-0.50.40.1-0.1
Cocaine response before conditioning0.81.03.1-0.50.1-0.30.90.2-1.71.7
Saline control response1.72.28.0-0.2-0.00.00.90.9-2.42.8
Bone: connectivity density1.62.53.6-1.51.6-1.31.9-1.2-1.91.5
Bone: cortical apparent density1.11.52.4-1.11.5-1.41.2-1.50.6-0.9
Bone: cortical area3.85.88.82.3-2.22.1-2.41.73.0-2.8
Bone: cortical porosity1.61.82.91.6-1.71.6-1.21.70.6-0.3
Bone: cortical porosity2.22.44.01.8-2.01.9-1.41.90.7-0.4
Bone: cortical thickness1.72.88.71.1-0.60.6-0.70.33.0-2.9
Bone: cortical thickness1.01.13.50.7-0.50.4-0.30.51.9-1.8
Bone: cortical tissue density1.21.52.5-1.21.5-1.41.3-1.60.5-0.9
Condit. Reinf. active minus inactive responses0.20.30.6-0.50.2-0.40.5-0.1-0.80.8
Condit. Reinf. active-inactive response ratio0.20.30.7-0.50.1-0.40.4-0.3-0.80.6
Condit. Reinf. active responses0.81.01.9-0.90.5-0.91.0-0.3-1.41.4
Condit. Reinf. inactive responses0.81.01.5-1.00.8-1.01.1-0.5-1.11.2
Incentive salience index mean0.20.20.7-0.2-0.1-0.10.30.3-0.80.8
Condit. Reinf. lever presses0.10.10.3-0.3-0.2-0.30.40.1-0.50.6
Condit. Reinf. active minus inactive responses0.40.50.70.5-0.80.7-0.40.8-0.60.8
Condit. Reinf. active-inactive response ratio0.20.20.50.3-0.50.4-0.10.5-0.50.7
Condit. Reinf. active responses0.10.10.4-0.40.0-0.30.2-0.1-0.60.5
Condit. Reinf. inactive responses0.50.71.0-1.00.8-0.90.8-0.7-0.80.6
Condit. Reinf. lever presses1.01.42.1-1.40.8-1.31.2-0.9-1.41.1
Condit. Reinf. lever reinforcers received0.10.20.3-0.60.3-0.50.3-0.6-0.40.1
Conditioned reinforcement - actives0.70.71.5-1.00.8-1.11.0-1.2-0.1-0.1
Conditioned reinforcement - inactives0.20.20.40.6-0.50.6-0.30.50.6-0.5
Conditioned locomotion1.01.23.1-1.20.9-1.31.0-1.80.1-0.4
Patch foraging indifference point 0 sec0.81.32.3-1.51.1-1.50.8-1.2-0.90.7
Patch foraging indifference point AUC2.73.14.7-1.61.6-1.51.9-1.1-2.22.2
Delay disc. indifference point, 0s delay1.41.63.51.3-1.91.3-0.81.9-0.10.5
Delay disc. indifference point, 16s delay0.30.30.4-0.60.4-0.60.5-0.5-0.70.6
Delay disc. indifference point, 2s delay0.70.82.70.6-1.60.7-0.51.2-0.20.5
Delay disc. indifference point, 24s delay0.10.10.3-0.2-0.2-0.10.20.1-0.50.5
Delay disc. indifference point, 4s delay1.41.42.81.2-1.71.3-0.91.7-0.30.7
Delay disc. indifference point, 8s delay3.53.66.82.1-2.42.3-1.72.60.00.5
Indifference point function ln k1.52.17.20.5-0.30.2-0.9-0.32.4-2.7
Indifference point function log k1.52.17.20.5-0.30.2-0.9-0.32.4-2.7
Patch foraging total patch changes 0 sec1.11.83.1-1.81.4-1.71.0-1.4-1.00.7
Patch foraging total patch changes 12 sec4.15.36.6-2.62.5-2.52.2-2.2-2.22.0
Patch foraging total patch changes 18 sec3.03.95.7-2.21.7-1.91.7-1.6-2.42.2
Patch foraging total patch changes 24 sec0.50.62.2-0.1-0.20.1-0.30.5-1.31.5
Patch foraging total patch changes 6 sec1.92.83.6-1.91.8-1.91.6-1.7-1.41.2
Patch foraging time to switch 0 sec0.20.30.60.8-0.50.8-0.50.50.4-0.3
Patch foraging water rate 0 sec0.71.11.6-1.30.9-1.20.7-0.7-1.31.2
Patch foraging water rate 12 sec0.81.23.5-0.30.8-0.6-0.3-1.11.6-1.9
Patch foraging water rate 18 sec0.30.40.9-0.70.7-0.70.3-0.90.2-0.5
Patch foraging water rate 24 sec1.52.13.5-1.71.7-1.71.1-1.9-0.80.5
Patch foraging water rate 6 sec0.20.30.9-0.10.2-0.3-0.2-0.50.8-0.9
Seeking ratio, delayed vs. immediate footshock0.40.51.1-0.40.5-0.30.90.2-1.01.1
Distance traveled before self-admin1.11.12.21.1-1.51.2-0.71.5-0.20.5
Distance traveled after self-admin1.41.52.7-1.51.4-1.41.0-1.7-0.80.5
Extensor digitorum longus weight0.93.66.1-2.32.2-2.52.1-2.1-0.4-0.0
Bone: elastic displacement0.70.81.3-0.91.1-1.10.9-1.00.3-0.6
Bone: elastic work1.01.33.80.8-0.40.5-0.80.21.9-2.0
Bone: endosteal estimation0.51.12.70.7-1.41.0-1.61.00.1-0.3
Bone: endosteal perimeter3.16.311.22.5-3.32.9-3.12.90.7-0.6
Epididymis fat weight0.51.23.80.4-0.10.2-0.9-0.41.8-2.0
Delta time in closed arm before/after self-admin0.30.30.40.5-0.20.6-0.60.6-0.40.6
Delta time in open arm before/after self-admin1.11.12.1-1.10.8-1.11.5-0.4-1.01.0
Diff in mean of infusions in LGA sessions0.70.81.50.6-0.70.6-1.2-0.01.1-1.2
Delay discount exponential model param1.61.73.7-1.21.9-1.41.0-1.80.2-0.6
Extinction: sum of active levers before priming0.20.20.60.1-0.10.0-0.3-0.30.7-0.8
Active lever presses in extinction session 60.40.41.1-0.40.8-0.4-0.2-1.10.4-0.6
Bone: final force1.32.23.01.6-1.31.5-1.41.01.7-1.7
Bone: final moment1.52.43.31.7-1.31.5-1.51.11.8-1.8
Food consumed during 24 hour testing period0.70.93.0-0.2-0.10.10.30.8-1.61.7
Glucose0.40.62.10.30.20.10.1-0.11.3-1.4
Heart weight1.31.85.70.7-0.30.4-0.9-0.42.3-2.4
Delay discount hyperbolic model param1.51.63.7-1.11.9-1.31.0-1.70.2-0.6
Intermittent access intake day 1-15 change0.40.41.00.4-0.20.50.20.9-0.71.0
Intermittent access intake escalation0.50.51.70.10.10.30.40.7-1.01.3
Intermittent access intake escalation 20.60.61.6-0.30.6-0.20.80.1-1.11.2
Intermitt. access day 1 inactive lever presses1.71.92.81.6-1.51.7-1.41.60.7-0.5
Intermitt. access day 15 inactive lever presses0.40.50.7-0.60.7-0.60.8-0.4-0.80.8
Intermitt. access escalation Index0.70.61.50.7-0.70.9-0.71.2-0.40.6
Intermittent access day 1 total infusions0.70.82.60.3-0.50.2-0.7-0.61.4-1.6
Intermittent access day 15 total infusions0.00.00.00.1-0.10.2-0.00.0-0.10.2
Intermittent access terminal intake (last 3 days)0.10.10.20.4-0.40.5-0.40.20.3-0.2
Intermittent access total infusions0.20.30.70.3-0.30.3-0.5-0.20.7-0.8
Intermittent access day 1 locomotion0.60.62.0-0.80.5-0.90.5-1.40.3-0.6
Intermittent access day 15 total locomotion0.20.30.70.3-0.30.2-0.3-0.30.8-0.9
Intermittent access total locomotion0.30.41.3-0.50.4-0.60.4-1.10.4-0.6
Intermittent access standard deviation3.94.25.82.4-2.12.3-2.11.81.9-1.5
Left kidney weight3.08.610.63.3-3.13.1-3.22.62.8-2.3
Right kidney weight1.23.54.12.0-1.91.9-1.91.62.0-1.7
Cocaine induced anxiety0.50.61.30.7-0.60.8-0.21.1-0.60.9
Post-drug Anxiety0.50.51.9-0.20.2-0.00.20.1-1.21.4
Baseline Anxiety0.10.10.2-0.10.1-0.2-0.1-0.50.4-0.5
Tail length0.51.44.0-0.90.3-0.60.9-0.1-1.92.0
Length with tail1.03.66.12.1-2.52.2-1.92.30.8-0.3
Length without tail4.29.111.23.3-3.23.1-3.22.73.0-2.6
Times rat made contact with spout0.40.40.8-0.60.5-0.60.7-0.2-0.90.8
Lifetime Intake0.40.51.20.5-0.40.5-0.7-0.11.0-1.1
Liver weight, left2.54.15.72.4-2.02.3-2.21.81.8-1.5
Liver weight, right1.01.62.21.5-1.41.4-1.21.01.3-1.0
Locomotor activity0.00.00.2-0.2-0.4-0.20.00.1-0.0-0.1
Locomotor testing distance0.00.00.1-0.1-0.4-0.1-0.2-0.10.1-0.3
Locomotor testing rearing1.01.52.1-1.40.8-1.31.4-0.7-1.51.3
Locomotion in novel chamber1.21.43.6-1.00.7-0.71.0-0.3-1.91.8
Locomotion in novel chamber post-restriction0.10.10.30.2-0.20.3-0.50.1-0.30.2
Fecal boli incidents, locomotor time 10.40.50.8-0.70.6-0.80.2-0.90.5-0.8
Change in fecal boli incidents, locomotor task0.10.10.3-0.2-0.1-0.30.1-0.50.3-0.3
Time >=10cm from walls, locomotor time 10.30.30.90.1-0.20.20.20.5-0.90.9
Bouts of movement, locomotor time 10.10.10.50.0-0.2-0.10.1-0.00.7-0.7
Total resting periods, locomotor time 10.10.10.4-0.1-0.0-0.20.3-0.20.6-0.6
Rest time, locomotor task time 10.80.92.60.6-0.10.4-0.6-0.51.6-1.6
Distance moved, locomotor task time 10.70.72.2-0.50.4-0.40.60.0-1.41.5
Vertical activity count, locomotor time 11.61.72.9-1.41.1-1.21.1-0.7-1.71.7
Time >=10cm from walls, locomotor time 20.30.30.9-0.50.6-0.50.9-0.3-0.40.4
Bouts of movement, locomotor time 20.20.20.40.4-0.20.4-0.5-0.10.6-0.6
Total resting periods, locomotor time 20.20.20.40.4-0.20.4-0.5-0.20.6-0.7
Rest time, locomotor task time 20.70.91.70.7-0.70.7-1.0-0.21.2-1.3
Distance moved, locomotor task time 20.10.10.3-0.30.3-0.30.40.1-0.40.5
Vertical activity count, locomotor time 20.10.10.3-0.40.2-0.5-0.0-0.10.00.0
Light reinforcement 11.83.34.3-2.02.1-2.01.8-1.9-1.51.3
Light reinforcement 20.30.41.0-0.40.7-0.30.2-0.4-0.81.0
Bone: marrow area0.51.12.80.8-1.51.1-1.71.00.1-0.3
Bone: maximum diameter6.111.115.23.5-3.93.6-3.83.32.6-2.3
Bone: maximum force1.62.85.21.6-1.21.4-1.80.62.2-2.3
Bone: maximum moment1.73.05.41.7-1.21.5-1.90.72.3-2.3
Mean time between licks in bursts0.00.00.10.1-0.20.10.30.20.2-0.3
Mean num. licks in bursts0.50.60.9-0.90.9-0.90.7-0.9-0.50.3
Cd content in liver0.80.81.1-0.71.0-0.90.9-1.00.8-1.0
Co content in liver0.50.51.2-0.81.1-0.80.5-0.90.2-0.4
Cu content in liver0.10.10.30.1-0.20.1-0.40.50.3-0.3
Fe content in liver0.30.30.80.1-0.50.3-0.20.6-0.80.9
K content in liver0.30.31.2-0.10.1-0.00.10.3-1.01.1
Mg content in liver1.71.72.1-1.41.5-1.41.4-1.2-1.31.0
Mn content in liver0.60.71.21.0-0.81.1-0.91.00.00.2
Na content in liver0.50.51.10.6-0.70.7-0.51.1-0.60.8
Rb content in liver2.43.04.2-1.92.0-1.92.1-1.8-1.21.0
Se content in liver1.21.44.1-0.80.4-0.61.00.2-2.02.0
Sr content in liver0.20.20.60.40.00.2-0.40.10.7-0.7
Zn content in liver1.51.72.01.4-1.41.3-1.41.31.2-1.1
Bone: minimum diameter2.03.86.62.0-2.62.1-2.32.11.1-1.0
Time in familiar zone, hab. session 10.00.00.1-0.20.2-0.30.2-0.2-0.10.1
Time in novel zone, hab. session 10.20.20.50.6-0.40.7-0.30.6-0.10.2
Total zone transitions, hab. session 11.72.33.4-1.81.5-1.81.8-1.3-1.30.9
Total locomotion distance, hab. session 11.31.83.0-1.71.3-1.71.5-1.2-1.00.8
Locomotion velocity, hab. session 11.62.34.0-1.91.4-2.01.7-1.4-1.00.7
Time in familiar zone, hab. session 20.20.20.5-0.20.7-0.3-0.1-0.70.2-0.3
Time in novel zone, hab. session 20.30.30.50.6-0.70.7-0.40.70.1-0.1
Total zone transitions, hab. session 25.16.59.6-3.12.9-3.12.7-2.8-1.61.0
Total locomotion distance, hab. session 24.66.19.3-2.92.9-3.12.5-2.9-1.20.7
Locomotion velocity, hab. session 24.66.29.5-3.02.8-3.12.5-2.8-1.40.9
Novel to familiar place preference ratio1.92.03.0-1.71.7-1.71.4-1.7-0.60.2
Novelty place preference1.51.52.2-1.51.5-1.51.2-1.5-0.50.2
Time in novel zone, NPP test1.81.82.8-1.61.6-1.61.4-1.7-0.60.2
Total zone transitions, NPP test3.65.17.4-2.72.5-2.72.3-2.2-1.71.3
Total locomotion distance, NPP test5.77.812.5-3.43.2-3.52.9-3.0-1.40.9
Locomotion velocity, NPP test4.86.811.0-3.23.0-3.32.7-2.8-1.30.9
Intraocular pressure0.70.92.1-1.11.3-1.00.4-1.4-0.2-0.0
Delta distance traveled before/after self-admin2.93.15.4-2.02.3-2.01.6-2.3-0.60.1
Delta ambulatory time before/after self-admin3.33.66.3-2.22.5-2.21.7-2.5-0.80.3
Parametrial fat weight0.10.10.40.1-0.00.0-0.6-0.20.5-0.4
Pavlov. Cond. lever latency0.70.92.1-0.91.4-0.80.7-1.3-0.50.3
Pavlov. Cond. magazine entry latency2.02.54.51.7-2.11.8-1.62.00.4-0.0
Pavlov. Cond. change in total contacts0.20.30.7-0.30.1-0.50.3-0.50.7-0.9
Pavlov. Cond. index score1.51.93.71.4-1.91.4-1.41.70.6-0.4
Pavlov. Cond. latency score2.02.54.71.7-2.21.6-1.62.00.8-0.4
Pavlov. Cond. lever contacts0.20.30.70.4-0.80.3-0.30.70.5-0.4
Pavlov. Cond. magazine entry number2.83.55.8-2.12.4-2.12.0-2.1-1.10.8
Pavlov. Cond. intertrial magazine entries2.12.53.8-1.71.7-1.71.9-1.6-1.31.0
Pavlov. Cond. lever-magazine prob. diff.1.11.32.81.2-1.71.2-1.11.50.5-0.3
Pavlov. Cond. response bias1.41.73.21.4-1.81.4-1.31.50.8-0.6
Pavlov. Cond. lever latency1.01.32.31.5-0.81.4-1.21.11.1-0.8
Pavlov. Cond. magazine entry latency0.50.51.2-0.60.6-0.70.2-1.10.6-0.9
Pavlov. Cond. change in total contacts0.71.01.7-1.30.9-1.21.0-1.3-0.3-0.0
Pavlov. Cond. index score0.50.71.3-1.10.5-1.10.9-1.0-0.40.1
Pavlov. Cond. latency score0.30.40.8-0.90.3-0.80.6-0.8-0.30.1
Pavlov. Cond. lever contacts1.31.72.6-1.60.6-1.41.4-0.8-1.61.3
Pavlov. Cond. magazine entry number0.60.81.71.1-0.81.1-0.71.3-0.10.4
Pavlov. Cond. intertrial magazine entries1.31.75.6-0.6-0.1-0.30.40.6-2.32.4
Pavlov. Cond. lever-magazine prob. diff.0.60.81.5-1.20.6-1.10.9-1.1-0.50.2
Pavlov. Cond. response bias0.70.91.7-1.30.6-1.21.1-0.9-0.80.5
Time in closed arm before self-admin0.10.10.40.1-0.1-0.10.2-0.20.6-0.6
Time in closed arm after self-admin2.12.12.91.6-1.31.6-1.71.01.5-1.3
Time in open arm before self-admin0.30.30.60.7-0.10.7-0.80.50.4-0.4
Time in open arm after self-admin0.70.71.2-0.91.1-0.80.9-0.6-0.90.7
Bone: periosteal estimation2.34.77.02.0-2.52.1-2.61.92.0-2.0
Bone: periosteal perimeter5.69.312.63.2-3.63.2-3.43.02.5-2.2
Bone: post-yield work0.50.71.8-0.91.0-0.90.6-1.30.0-0.4
Progressive ratio test 1 active lever presses0.10.10.3-0.40.3-0.30.2-0.6-0.20.1
Progressive ratio test 1 breakpoint0.10.10.4-0.30.3-0.20.0-0.60.1-0.2
Progressive ratio test 1 inactive lever presses0.20.20.60.5-0.80.6-0.30.60.00.1
Progressive ratio test 2 active lever presses0.20.20.7-0.40.3-0.50.1-0.80.4-0.6
Progressive ratio test 2 breakpoint0.20.30.7-0.50.4-0.50.3-0.80.3-0.5
Progressive ratio test 2 inactive lever presses0.00.00.10.10.10.10.1-0.20.3-0.3
Incentive Sensitization - Responses0.90.91.70.9-1.00.7-0.90.41.3-1.2
Incentive Sensitization - Breakpoint1.11.11.81.0-1.10.9-1.00.61.3-1.2
Sum of active levers in priming session hrs 5-60.30.30.70.3-0.40.3-0.7-0.10.7-0.9
Progressive ratio0.50.51.60.0-0.2-0.1-0.6-0.71.1-1.3
Food seeking constrained by brief footshock0.81.01.61.0-1.00.9-1.10.51.2-1.1
Seeking ratio, punishment vs. effort0.30.41.10.6-0.60.6-0.11.1-0.50.7
Retroperitoneal fat weight0.41.32.41.1-1.01.1-1.50.71.2-1.0
Reaction time number correct3.45.06.3-2.52.5-2.32.2-1.9-2.21.9
Reaction time mean minus median0.60.81.11.1-0.91.0-0.80.90.9-0.6
Reaction time mean minus median AUC0.81.01.61.2-1.11.2-1.01.30.3-0.0
Reaction time num false alarms0.10.10.3-0.50.1-0.40.1-0.5-0.10.1
Reaction time num false alarms AUC0.20.30.8-0.80.4-0.70.3-0.9-0.30.2
Reaction time trials correct on left3.45.06.3-2.52.5-2.32.2-1.9-2.21.9
Reaction time trials on left3.44.96.2-2.52.5-2.32.2-1.9-2.21.9
Reaction time mean0.10.10.20.3-0.30.3-0.10.10.5-0.4
Reaction time mean AUC0.10.10.30.1-0.10.10.0-0.10.5-0.6
Median of all reaction times0.00.10.10.2-0.30.10.10.10.4-0.4
Reaction time omissions0.60.81.41.0-0.91.0-1.11.20.4-0.1
Reaction time false alarm rate0.30.40.80.6-0.90.5-0.80.30.8-0.7
Reaction time premature initiation rate2.12.95.2-1.92.0-2.01.8-2.3-0.2-0.3
Reaction time premature initiations4.86.810.0-3.03.2-3.12.7-3.2-1.20.6
Std. dev. reaction times0.10.20.40.4-0.30.3-0.30.20.6-0.5
Reaction time trials completed3.44.96.2-2.52.5-2.32.2-1.9-2.21.9
Reaction time trials AUC4.05.87.4-2.72.7-2.62.4-2.1-2.31.9
Run reversals in cocaine runway, females0.20.20.50.3-0.70.3-0.60.30.5-0.3
Run reversals in cocaine runway, males0.90.92.60.30.20.1-0.8-0.61.6-1.6
Latency to leave start box in cocaine runway0.40.51.1-0.50.8-0.60.2-1.10.5-0.7
Latency to leave start box in cocaine runway, F0.60.71.6-0.81.3-0.80.6-1.1-0.30.2
Latency to leave start box in cocaine runway, M0.70.61.1-0.80.6-1.00.6-1.00.6-0.9
Std. dev. time between licks in bursts1.82.22.9-1.61.4-1.51.5-1.0-1.71.5
Total sessions with >9 infusions1.41.53.01.1-0.91.0-1.30.21.7-1.7
Short access day 1 total inactive lever presses0.40.40.60.7-0.40.6-0.80.30.7-0.8
Short access day 10 total inactive lever presses0.70.81.71.1-0.81.2-0.71.30.00.2
Short access day 1 total infusions1.41.52.21.2-0.91.1-1.40.61.5-1.5
Short access day 10 total infusions1.51.72.71.2-1.21.2-1.60.51.5-1.5
Short access total infusions0.60.71.90.6-0.30.5-0.9-0.21.3-1.4
Short access day 1 locomotion0.50.50.90.7-0.70.6-0.70.21.0-1.0
Short access day 10 total locomotion0.60.61.20.7-0.70.6-0.70.21.1-1.1
Short access total locomotion1.81.84.11.2-1.00.9-1.20.22.0-2.0
One hour access (0.3 mA shock)0.20.30.8-0.50.6-0.50.2-0.90.2-0.4
Compulsive drug intake0.60.61.1-0.71.1-0.80.6-1.00.3-0.5
One hour access (shock baseline)0.00.00.10.0-0.30.1-0.00.0-0.30.3
Social response proportion0.40.40.6-0.60.7-0.70.7-0.80.3-0.4
Social responses0.10.20.6-0.30.3-0.40.8-0.0-0.40.4
Social time0.40.50.9-0.80.8-0.90.7-0.70.2-0.3
Soleus weight0.41.22.1-1.21.3-1.41.4-1.20.0-0.1
Bone: stiffness1.72.63.71.8-1.51.6-1.51.11.9-1.8
Tibialis anterior weight0.10.30.5-0.60.5-0.70.6-0.60.4-0.5
Time to tail flick, vehicle, before self-admin0.40.51.2-0.70.5-0.81.10.1-0.50.5
Time to tail flick, vehicle, after self-admin2.12.35.21.4-0.81.2-1.40.32.3-2.2
Time to tail flick, test, before self-admin0.70.61.6-0.7-0.0-0.50.70.2-1.31.3
Time to tail flick, test, after self-admin0.80.81.00.9-0.70.9-1.00.81.0-0.9
Delta time to tail flick, vehicle, before/after SA0.50.51.20.40.00.3-0.8-0.61.0-1.1
Delta time to tail flick, test, before/after SA1.91.73.01.4-0.81.2-1.40.71.7-1.6
Tibia length10.629.941.66.4-6.26.4-5.86.13.5-2.2
Ambulatory time before self-admin1.71.83.51.5-1.91.5-1.01.80.10.4
Ambulatory time after self-admin0.50.61.4-0.80.9-0.80.4-1.2-0.50.3
Bone: tissue strength0.90.92.2-0.81.3-0.90.3-1.50.4-0.8
Total heroin consumption2.53.04.71.8-1.61.8-2.21.21.7-1.6
Bone: trabecular number0.50.71.5-0.80.7-0.61.0-0.4-1.21.0
Bone: trabecular spacing0.30.40.70.5-0.80.5-0.80.40.6-0.4
Bone: trabecular thickness0.40.51.0-0.80.7-0.81.0-0.5-0.50.2
Bone: trabecular tissue density0.20.20.70.3-0.80.3-0.60.60.10.2
Water consumed over 24 hours0.70.82.3-0.60.5-0.50.8-0.0-1.41.5
Number of responses in last shaping day2.32.43.41.7-1.81.6-1.41.51.5-1.3