Hub : Genes

Tha1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr10_103596983_103598523 0.03 0.03 7.0e-04 0.03 0.03 0.03 0.04 5.5e-04 8.5e-04 1.8e-03 1.9e-04
2 Liver mRNA stability Tha1 0.04 0.03 2.4e-06 0.04 0.04 0.04 0.04 8.9e-06 8.6e-06 3.9e-05 5.7e-05
3 NAcc isoform ratio XM_006247853.5 0.04 0.03 4.0e-04 0.02 0.02 0.01 0.01 1.0e-03 2.6e-04 7.0e-03 1.7e-03
4 BLA isoform ratio XM_006247853.5 0.06 0.05 3.7e-03 0.05 0.03 0.03 0.04 1.2e-03 1.0e-02 1.3e-02 3.6e-03
5 Adipose gene expression Tha1 0.07 0.04 2.6e-11 0.09 0.09 0.08 0.09 4.3e-10 4.4e-10 2.8e-09 7.1e-10
6 Liver gene expression Tha1 0.04 0.03 4.7e-08 0.05 0.05 0.04 0.06 1.1e-06 1.1e-06 2.2e-05 5.2e-07
7 NAcc gene expression Tha1 0.06 0.05 5.6e-03 0.01 0.01 0 0 2.8e-02 1.0e-02 7.5e-02 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.61.22.30.9-1.5-1.10.51.5-1.10.3
Area under the delay curve0.40.71.4-1.20.90.3-0.4-0.81.20.6
BMI with tail0.72.38.1-0.70.92.0-0.8-1.00.9-2.8
BMI without tail0.10.72.31.0-0.8-0.41.50.7-0.8-0.3
Body weight1.04.46.9-1.92.02.6-1.4-2.11.6-2.6
Weight adjusted by age0.00.00.1-0.2-0.1-0.0-0.1-0.2-0.1-0.1
Bone surface0.30.61.6-1.10.40.3-1.3-0.70.8-0.2
Bone volume0.10.10.6-0.5-0.3-0.1-0.8-0.10.2-0.3
Breakpoint value in progressive ratio session0.40.72.6-0.30.10.8-0.8-0.90.2-1.6
Number of licking bursts0.00.00.1-0.10.20.10.1-0.10.20.1
Context. condit. distance diff. score0.30.30.6-0.60.40.5-0.7-0.80.4-0.5
Locomotion velocity, session 10.40.40.8-0.80.90.3-0.2-0.30.90.7
Locomotion distance, session 12.32.94.11.9-1.8-1.72.01.7-1.61.1
Locomotion velocity, session 20.50.60.70.7-0.8-0.80.70.8-0.90.5
Locomotion distance, session 25.47.69.43.1-2.9-2.62.83.0-3.01.5
Locomotion velocity, session 30.30.31.6-0.00.2-0.50.6-0.00.41.3
Locomotion distance, session 30.10.10.40.4-0.2-0.10.60.3-0.1-0.1
Stereotopy head waving bouts, day 32.52.94.3-1.71.61.8-1.8-2.11.3-1.5
Stereotopy head waving duration, day 32.02.43.6-1.61.51.5-1.8-1.91.3-1.2
Locomotion velocity, session 70.30.30.90.3-0.4-0.70.50.4-0.11.0
Locomotion distance, session 73.03.85.62.1-2.2-1.91.82.0-2.40.9
Stereotopy head waving bouts, day 74.75.47.0-2.62.42.2-2.3-2.52.6-1.4
Stereotopy head waving duration, day 75.56.88.9-3.02.82.4-2.7-2.62.9-1.3
Locomotion velocity, session 80.20.20.5-0.70.60.1-0.5-0.50.30.5
Locomotion distance, session 82.13.14.52.0-2.1-1.71.61.6-2.00.7
Degree of sensitization distance3.84.15.52.0-2.3-2.21.72.0-2.31.5
Degree of sensitization stereotypy1.82.03.6-1.61.51.4-1.2-1.31.9-0.8
Conditioned locomotion0.40.41.20.7-0.6-0.61.10.4-0.60.3
Cocaine response after cond. corrected0.30.50.8-0.50.60.8-0.6-0.90.5-0.9
Cocaine response after cond. not corrected0.10.10.2-0.30.30.2-0.4-0.50.2-0.1
Cocaine response before conditioning0.80.92.80.5-0.6-1.20.40.9-0.61.7
Saline control response1.82.58.61.0-0.6-1.81.51.2-0.82.9
Bone: connectivity density1.52.54.11.4-1.7-1.71.12.0-1.61.3
Bone: cortical apparent density0.81.33.21.3-1.2-0.50.81.3-1.8-0.5
Bone: cortical area4.77.69.8-2.72.73.1-2.8-2.92.2-2.7
Bone: cortical porosity1.71.92.9-1.71.51.2-1.7-1.11.4-0.6
Bone: cortical porosity2.52.84.1-2.01.81.5-1.9-1.41.9-0.7
Bone: cortical thickness1.11.84.0-0.81.52.0-0.9-1.10.6-1.9
Bone: cortical thickness0.40.51.2-0.40.71.1-0.3-0.40.4-1.1
Bone: cortical tissue density0.91.43.41.3-1.3-0.50.81.3-1.8-0.5
Condit. Reinf. active minus inactive responses0.20.30.50.3-0.5-0.70.50.5-0.30.7
Condit. Reinf. active-inactive response ratio0.20.20.40.2-0.6-0.6-0.10.5-0.50.4
Condit. Reinf. active responses1.01.32.01.0-0.9-1.31.31.1-0.81.4
Condit. Reinf. inactive responses1.01.42.51.2-0.9-1.21.60.9-0.81.3
Incentive salience index mean0.10.20.60.1-0.2-0.50.30.4-0.10.8
Condit. Reinf. lever presses0.30.40.70.6-0.5-0.70.80.6-0.40.8
Condit. Reinf. active minus inactive responses0.10.10.4-0.40.3-0.2-0.4-0.20.30.6
Condit. Reinf. active-inactive response ratio0.10.10.4-0.20.3-0.20.0-0.10.20.6
Condit. Reinf. active responses0.20.20.40.3-0.6-0.60.10.5-0.50.4
Condit. Reinf. inactive responses0.71.01.51.0-1.2-1.10.71.0-1.20.6
Condit. Reinf. lever presses1.11.52.21.2-1.5-1.41.11.2-1.40.8
Condit. Reinf. lever reinforcers received0.20.30.60.4-0.8-0.50.10.5-0.7-0.1
Conditioned reinforcement - actives0.10.40.90.6-0.70.00.40.5-0.6-0.9
Conditioned reinforcement - inactives0.00.10.1-0.20.30.3-0.20.1-0.0-0.3
Conditioned locomotion0.50.71.40.8-1.2-0.40.60.9-1.0-0.7
Patch foraging indifference point 0 sec0.51.52.61.2-1.6-1.31.30.9-1.40.6
Patch foraging indifference point AUC1.33.05.31.6-1.4-2.11.81.7-1.12.3
Delay disc. indifference point, 0s delay0.50.51.3-1.21.00.2-0.5-0.50.60.8
Delay disc. indifference point, 16s delay0.20.30.40.4-0.5-0.60.60.5-0.50.5
Delay disc. indifference point, 2s delay0.40.41.6-0.90.50.1-0.1-0.51.20.4
Delay disc. indifference point, 24s delay0.00.10.20.0-0.1-0.30.20.1-0.30.5
Delay disc. indifference point, 4s delay0.80.81.6-1.21.00.3-0.6-0.81.30.7
Delay disc. indifference point, 8s delay1.72.84.7-2.12.01.2-1.4-1.82.20.2
Indifference point function ln k0.41.14.5-0.40.41.3-0.8-0.7-0.0-2.1
Indifference point function log k0.41.14.5-0.40.41.3-0.8-0.7-0.0-2.1
Patch foraging total patch changes 0 sec0.61.93.21.4-1.8-1.41.41.1-1.60.6
Patch foraging total patch changes 12 sec4.25.67.32.5-2.4-2.62.72.1-2.22.0
Patch foraging total patch changes 18 sec1.74.15.61.9-2.2-2.42.31.8-1.61.8
Patch foraging total patch changes 24 sec0.10.31.2-0.2-0.0-0.60.0-0.40.41.1
Patch foraging total patch changes 6 sec1.93.14.31.8-1.9-1.81.81.7-2.11.2
Patch foraging time to switch 0 sec0.10.30.4-0.40.60.6-0.5-0.50.5-0.3
Patch foraging water rate 0 sec0.31.21.71.2-1.3-1.31.20.7-1.01.0
Patch foraging water rate 12 sec0.10.52.00.5-0.40.4-0.1-0.1-1.0-1.4
Patch foraging water rate 18 sec0.10.30.60.5-0.7-0.20.30.2-0.7-0.6
Patch foraging water rate 24 sec1.31.93.01.7-1.7-1.31.51.1-1.60.3
Patch foraging water rate 6 sec0.10.10.40.2-0.20.20.2-0.1-0.1-0.6
Seeking ratio, delayed vs. immediate footshock0.20.30.90.3-0.2-0.60.10.6-0.30.9
Distance traveled before self-admin0.10.20.5-0.60.70.2-0.3-0.30.70.4
Distance traveled after self-admin0.71.32.41.2-1.5-1.11.01.1-1.40.2
Extensor digitorum longus weight0.93.86.42.2-2.1-1.52.52.0-2.10.4
Bone: elastic displacement0.70.91.61.3-0.9-0.61.01.0-1.1-0.0
Bone: elastic work1.01.33.1-0.71.01.5-1.0-1.00.3-1.7
Bone: endosteal estimation1.02.44.0-1.80.81.1-2.0-2.01.4-1.4
Bone: endosteal perimeter3.89.313.0-3.62.72.5-3.6-3.53.3-1.8
Epididymis fat weight0.10.62.9-0.10.21.0-0.3-0.50.0-1.7
Delta time in closed arm before/after self-admin0.30.20.70.5-0.4-0.70.40.2-0.20.8
Delta time in open arm before/after self-admin0.81.01.60.8-0.9-0.91.01.2-1.30.8
Diff in mean of infusions in LGA sessions0.71.31.9-1.20.71.1-1.3-1.41.0-1.4
Delay discount exponential model param0.70.91.91.3-1.1-0.50.61.0-1.4-0.5
Extinction: sum of active levers before priming0.10.10.8-0.0-0.20.30.1-0.2-0.1-0.9
Active lever presses in extinction session 60.10.10.70.3-0.20.20.2-0.3-0.0-0.8
Bone: final force1.82.94.0-1.81.82.0-1.9-1.51.1-1.7
Bone: final moment2.13.44.5-1.91.92.1-2.0-1.71.2-1.8
Food consumed during 24 hour testing period0.20.52.10.1-0.2-0.80.50.3-0.11.4
Glucose0.91.42.7-1.11.21.6-1.0-0.70.5-1.6
Heart weight1.32.14.5-0.91.31.9-1.0-1.21.2-2.1
Delay discount hyperbolic model param0.81.02.21.4-1.1-0.50.61.0-1.5-0.4
Intermittent access intake day 1-15 change0.00.20.4-0.30.70.2-0.2-0.10.60.6
Intermittent access intake escalation0.00.10.3-0.30.50.1-0.30.10.40.5
Intermittent access intake escalation 20.00.10.2-0.10.40.1-0.0-0.00.40.4
Intermitt. access day 1 inactive lever presses0.10.81.7-1.00.80.8-1.3-0.70.9-0.6
Intermitt. access day 15 inactive lever presses0.10.30.40.7-0.6-0.60.60.7-0.20.5
Intermitt. access escalation Index0.10.20.6-0.50.3-0.2-0.3-0.30.30.7
Intermittent access day 1 total infusions0.30.94.2-0.40.11.1-0.7-0.50.1-2.0
Intermittent access day 15 total infusions0.00.00.10.0-0.10.1-0.10.3-0.2-0.3
Intermittent access terminal intake (last 3 days)0.20.40.8-0.50.50.8-0.8-0.50.4-0.9
Intermittent access total infusions0.60.72.3-0.50.41.0-0.9-0.50.3-1.5
Intermittent access day 1 locomotion0.20.50.90.6-1.0-0.30.20.7-0.9-0.7
Intermittent access day 15 total locomotion0.10.20.9-0.20.10.5-0.4-0.10.2-1.0
Intermittent access total locomotion0.20.31.5-0.0-0.30.4-0.40.1-0.2-1.2
Intermittent access standard deviation1.68.410.3-2.73.03.2-2.8-3.03.0-2.5
Left kidney weight0.76.08.0-2.42.72.8-2.2-2.62.1-2.2
Right kidney weight0.32.13.4-1.31.51.8-1.1-1.41.0-1.7
Cocaine induced anxiety0.10.20.5-0.30.70.2-0.2-0.10.30.6
Post-drug Anxiety0.00.00.10.30.20.10.30.10.00.2
Baseline Anxiety0.10.10.40.2-0.6-0.10.20.0-0.3-0.6
Tail length0.10.72.60.3-0.3-1.01.10.3-0.41.6
Length with tail0.73.34.9-2.12.21.8-1.5-2.21.7-0.7
Length without tail1.89.611.6-3.23.23.4-3.1-3.32.7-2.8
Times rat made contact with spout0.40.50.80.5-0.7-0.80.90.8-0.40.7
Lifetime Intake0.80.93.1-0.60.51.2-1.0-0.70.2-1.8
Liver weight, left1.52.63.1-1.81.61.7-1.7-1.81.3-1.4
Liver weight, right0.81.42.3-1.51.41.1-1.2-1.21.2-0.6
Locomotor activity0.00.00.0-0.1-0.2-0.2-0.10.1-0.20.0
Locomotor testing distance0.00.10.3-0.1-0.40.0-0.40.1-0.3-0.5
Locomotor testing rearing0.41.42.20.9-1.4-1.50.81.3-0.91.1
Locomotion in novel chamber0.91.12.20.8-1.0-1.40.90.8-0.91.5
Locomotion in novel chamber post-restriction0.10.20.6-0.40.20.2-0.8-0.50.3-0.1
Fecal boli incidents, locomotor time 10.10.21.00.2-0.50.2-0.0-0.0-0.4-1.0
Change in fecal boli incidents, locomotor task0.00.00.1-0.1-0.00.20.1-0.0-0.0-0.3
Time >=10cm from walls, locomotor time 10.10.10.7-0.1-0.0-0.5-0.10.2-0.10.8
Bouts of movement, locomotor time 10.00.00.1-0.10.00.2-0.00.1-0.1-0.3
Total resting periods, locomotor time 10.00.00.10.0-0.10.10.10.3-0.2-0.3
Rest time, locomotor task time 10.71.13.0-0.60.81.4-1.0-0.80.6-1.7
Distance moved, locomotor task time 10.30.72.20.6-0.5-1.10.80.6-0.31.5
Vertical activity count, locomotor time 10.32.33.41.5-1.4-1.81.81.2-0.81.9
Time >=10cm from walls, locomotor time 20.20.50.90.5-0.4-0.60.60.9-0.90.6
Bouts of movement, locomotor time 20.10.30.7-0.40.40.7-0.6-0.50.3-0.8
Total resting periods, locomotor time 20.10.40.8-0.50.40.7-0.7-0.40.2-0.9
Rest time, locomotor task time 20.91.52.7-1.10.81.3-1.4-1.11.1-1.7
Distance moved, locomotor task time 20.40.51.10.7-0.3-0.70.90.5-0.51.1
Vertical activity count, locomotor time 20.10.20.70.6-0.4-0.40.90.0-0.20.3
Light reinforcement 11.04.46.02.4-2.2-2.32.52.0-1.51.7
Light reinforcement 20.30.61.40.9-0.5-0.91.10.4-0.11.2
Bone: marrow area1.02.43.8-1.80.81.1-2.0-2.01.4-1.3
Bone: maximum diameter8.216.520.3-4.53.94.0-4.5-4.43.9-3.1
Bone: maximum force2.14.15.9-2.01.82.4-2.1-1.91.2-2.4
Bone: maximum moment2.44.66.4-2.11.92.5-2.3-2.11.3-2.5
Mean time between licks in bursts0.00.00.1-0.20.20.2-0.30.2-0.2-0.1
Mean num. licks in bursts0.20.61.00.8-1.0-0.80.80.8-0.80.3
Cd content in liver0.60.71.21.0-1.1-0.50.70.9-1.0-0.4
Co content in liver0.00.00.1-0.1-0.00.1-0.2-0.20.1-0.2
Cu content in liver0.10.10.2-0.50.30.2-0.2-0.40.2-0.0
Fe content in liver0.10.20.6-0.1-0.2-0.60.4-0.30.00.8
K content in liver0.60.61.50.7-0.6-1.00.40.7-0.31.2
Mg content in liver2.52.83.51.7-1.8-1.91.31.9-1.61.4
Mn content in liver0.00.10.1-0.30.30.0-0.1-0.10.10.4
Na content in liver0.10.10.3-0.1-0.1-0.3-0.50.10.10.5
Rb content in liver1.61.92.61.5-1.5-1.41.41.6-1.30.9
Se content in liver1.51.82.81.2-1.3-1.61.21.2-0.91.7
Sr content in liver0.10.10.4-0.00.10.4-0.3-0.2-0.1-0.6
Zn content in liver0.10.20.2-0.50.30.3-0.4-0.40.5-0.3
Bone: minimum diameter3.26.19.4-2.82.22.2-3.1-2.82.3-1.6
Time in familiar zone, hab. session 10.00.00.10.3-0.2-0.20.20.2-0.00.2
Time in novel zone, hab. session 10.20.20.4-0.70.60.3-0.6-0.30.60.2
Total zone transitions, hab. session 11.92.73.31.7-1.7-1.61.81.7-1.81.0
Total locomotion distance, hab. session 11.82.53.11.8-1.6-1.51.71.6-1.61.0
Locomotion velocity, hab. session 12.33.34.32.0-1.9-1.72.01.8-2.11.0
Time in familiar zone, hab. session 20.00.10.10.4-0.2-0.00.0-0.1-0.3-0.3
Time in novel zone, hab. session 20.30.30.6-0.80.60.5-0.8-0.40.6-0.2
Total zone transitions, hab. session 25.36.79.82.9-2.9-2.42.62.6-3.11.1
Total locomotion distance, hab. session 25.47.010.13.2-2.9-2.42.72.5-3.11.1
Locomotion velocity, hab. session 25.67.510.53.2-2.9-2.52.92.6-3.21.3
Novel to familiar place preference ratio1.21.62.81.4-1.7-1.21.01.4-1.30.2
Novelty place preference0.91.22.11.2-1.5-1.00.91.2-1.10.2
Time in novel zone, NPP test1.21.52.61.3-1.6-1.21.01.4-1.30.2
Total zone transitions, NPP test3.95.77.42.7-2.6-2.42.62.2-2.61.5
Total locomotion distance, NPP test6.69.212.73.6-3.3-2.83.33.0-3.31.5
Locomotion velocity, NPP test5.67.911.03.3-3.1-2.63.12.8-3.01.4
Intraocular pressure0.30.41.00.8-1.0-0.40.90.2-0.2-0.5
Delta distance traveled before/after self-admin1.61.73.01.5-1.6-1.01.21.3-1.7-0.0
Delta ambulatory time before/after self-admin1.32.23.71.7-1.8-1.31.21.4-1.90.2
Parametrial fat weight0.00.10.3-0.2-0.00.2-0.0-0.4-0.2-0.5
Pavlov. Cond. lever latency0.20.20.60.5-0.8-0.50.40.5-0.50.0
Pavlov. Cond. magazine entry latency2.02.53.8-1.91.81.3-1.9-1.71.6-0.3
Pavlov. Cond. change in total contacts0.20.20.50.2-0.30.1-0.00.4-0.7-0.6
Pavlov. Cond. index score1.11.41.9-1.41.41.1-1.3-1.31.1-0.4
Pavlov. Cond. latency score1.41.82.6-1.61.61.2-1.4-1.51.4-0.4
Pavlov. Cond. lever contacts0.10.10.2-0.30.40.4-0.2-0.30.1-0.2
Pavlov. Cond. magazine entry number2.43.14.12.0-2.0-1.72.01.9-1.60.9
Pavlov. Cond. intertrial magazine entries2.12.53.81.6-1.7-1.61.62.0-1.41.0
Pavlov. Cond. lever-magazine prob. diff.0.70.91.3-1.11.10.9-1.1-1.00.8-0.3
Pavlov. Cond. response bias1.31.72.2-1.51.51.3-1.5-1.41.1-0.7
Pavlov. Cond. lever latency0.81.11.8-0.91.31.3-0.8-1.01.0-0.9
Pavlov. Cond. magazine entry latency0.10.20.90.4-0.60.10.10.2-0.2-0.9
Pavlov. Cond. change in total contacts0.40.91.81.0-1.3-0.80.71.1-0.9-0.0
Pavlov. Cond. index score0.30.51.10.8-1.1-0.70.50.8-0.7-0.0
Pavlov. Cond. latency score0.20.30.70.5-0.8-0.50.30.5-0.4-0.1
Pavlov. Cond. lever contacts1.31.92.71.3-1.6-1.61.31.3-1.21.1
Pavlov. Cond. magazine entry number0.20.20.6-0.60.80.3-0.4-0.40.40.4
Pavlov. Cond. intertrial magazine entries0.51.03.50.5-0.7-1.40.70.4-0.61.9
Pavlov. Cond. lever-magazine prob. diff.0.30.51.10.7-1.0-0.70.50.8-0.6-0.0
Pavlov. Cond. response bias0.91.32.21.3-1.5-1.11.11.1-1.10.3
Time in closed arm before self-admin0.10.20.4-0.30.50.7-0.2-0.10.3-0.7
Time in closed arm after self-admin1.01.21.7-0.80.91.2-1.2-1.10.9-1.3
Time in open arm before self-admin0.00.00.00.10.1-0.1-0.2-0.2-0.00.1
Time in open arm after self-admin0.91.01.91.0-1.0-1.00.90.9-1.40.7
Bone: periosteal estimation3.37.810.3-3.02.42.8-3.1-3.22.4-2.6
Bone: periosteal perimeter7.214.116.8-4.13.73.7-4.0-4.13.8-2.7
Bone: post-yield work0.10.20.50.3-0.6-0.0-0.10.4-0.5-0.7
Progressive ratio test 1 active lever presses0.10.20.40.4-0.5-0.00.10.2-0.6-0.6
Progressive ratio test 1 breakpoint0.10.20.40.4-0.5-0.00.10.2-0.6-0.6
Progressive ratio test 1 inactive lever presses0.00.00.1-0.20.10.2-0.3-0.00.1-0.2
Progressive ratio test 2 active lever presses0.20.30.70.4-0.60.00.10.5-0.7-0.8
Progressive ratio test 2 breakpoint0.20.20.70.3-0.50.1-0.00.4-0.6-0.9
Progressive ratio test 2 inactive lever presses0.00.10.3-0.10.20.4-0.20.00.0-0.6
Incentive Sensitization - Responses0.20.61.1-0.80.71.0-0.9-0.60.5-1.0
Incentive Sensitization - Breakpoint0.40.81.2-0.90.81.1-1.0-0.70.6-1.1
Sum of active levers in priming session hrs 5-60.50.51.8-0.40.20.8-0.7-0.50.5-1.3
Progressive ratio0.20.72.9-0.40.10.9-0.7-0.70.4-1.7
Food seeking constrained by brief footshock1.51.92.2-1.41.21.5-1.4-1.21.5-1.4
Seeking ratio, punishment vs. effort0.10.20.5-0.40.60.0-0.10.00.50.7
Retroperitoneal fat weight0.00.00.2-0.1-0.2-0.10.2-0.10.4-0.0
Reaction time number correct1.45.16.32.5-2.4-2.42.42.1-2.01.8
Reaction time mean minus median0.10.40.8-0.60.90.8-0.5-0.70.4-0.5
Reaction time mean minus median AUC0.10.61.3-0.81.20.7-0.7-0.90.80.1
Reaction time num false alarms0.00.10.2-0.1-0.2-0.0-0.3-0.20.5-0.2
Reaction time num false alarms AUC0.00.10.20.2-0.5-0.3-0.1-0.00.2-0.2
Reaction time trials correct on left1.45.16.32.5-2.4-2.42.42.1-2.01.8
Reaction time trials on left1.55.06.22.5-2.4-2.42.42.1-2.01.8
Reaction time mean0.00.10.2-0.20.20.3-0.10.0-0.3-0.4
Reaction time mean AUC0.00.10.2-0.10.00.20.10.1-0.5-0.5
Median of all reaction times0.00.10.2-0.30.00.2-0.10.2-0.4-0.4
Reaction time omissions0.61.12.1-1.11.20.9-0.7-1.51.1-0.3
Reaction time false alarm rate0.81.01.8-1.00.80.9-1.3-1.01.1-0.9
Reaction time premature initiation rate2.03.05.11.8-2.0-1.41.72.0-2.30.2
Reaction time premature initiations2.37.19.83.0-3.1-2.42.72.9-3.00.9
Std. dev. reaction times0.00.10.1-0.10.30.40.0-0.1-0.2-0.4
Reaction time trials completed1.55.06.22.5-2.4-2.42.42.1-2.01.8
Reaction time trials AUC1.75.97.32.7-2.6-2.62.62.3-2.21.8
Run reversals in cocaine runway, females0.30.41.3-0.40.50.50.1-0.71.2-0.3
Run reversals in cocaine runway, males0.50.52.2-0.10.20.9-0.5-0.70.1-1.5
Latency to leave start box in cocaine runway0.10.20.40.5-0.40.00.10.1-0.6-0.6
Latency to leave start box in cocaine runway, F0.40.51.01.0-0.8-0.60.50.6-0.90.1
Latency to leave start box in cocaine runway, M0.20.21.0-0.2-0.10.4-0.2-0.2-0.2-1.0
Std. dev. time between licks in bursts1.52.93.71.7-1.7-1.91.81.6-1.71.6
Total sessions with >9 infusions2.63.38.3-1.41.22.1-1.8-1.70.9-2.9
Short access day 1 total inactive lever presses1.12.22.9-1.51.51.7-1.7-1.51.1-1.4
Short access day 10 total inactive lever presses0.10.50.9-0.70.80.1-0.7-0.41.00.9
Short access day 1 total infusions1.32.55.5-1.31.21.9-1.5-1.50.9-2.3
Short access day 10 total infusions1.83.05.9-1.51.11.9-1.9-1.71.2-2.4
Short access total infusions1.31.85.2-0.90.71.6-1.3-1.20.5-2.3
Short access day 1 locomotion0.81.33.3-1.00.71.4-1.1-1.00.6-1.8
Short access day 10 total locomotion0.31.42.4-1.00.91.3-1.3-1.11.0-1.5
Short access total locomotion2.23.46.0-1.61.42.1-2.0-1.71.3-2.4
One hour access (0.3 mA shock)0.20.30.70.6-0.60.00.40.4-0.5-0.8
Compulsive drug intake0.40.50.80.9-0.7-0.60.80.6-0.80.4
One hour access (shock baseline)0.00.10.3-0.20.10.3-0.1-0.10.2-0.5
Social response proportion0.20.20.60.6-0.4-0.20.80.40.1-0.2
Social responses0.30.30.90.6-0.2-0.40.90.70.10.7
Social time0.10.20.60.8-0.4-0.20.70.3-0.3-0.1
Soleus weight0.51.33.01.2-0.9-0.81.71.4-1.10.5
Bone: stiffness1.73.14.2-1.91.82.0-1.8-1.51.3-1.8
Tibialis anterior weight0.10.30.80.5-0.5-0.10.90.6-0.7-0.4
Time to tail flick, vehicle, before self-admin0.30.30.60.4-0.4-0.50.70.7-0.80.6
Time to tail flick, vehicle, after self-admin1.02.12.9-1.21.51.7-1.5-1.41.4-1.4
Time to tail flick, test, before self-admin1.31.52.20.8-1.1-1.41.21.3-1.01.5
Time to tail flick, test, after self-admin1.92.02.6-1.51.61.5-1.3-1.51.4-0.9
Delta time to tail flick, vehicle, before/after SA0.80.91.4-0.80.80.9-1.1-1.01.2-0.8
Delta time to tail flick, test, before/after SA2.83.54.4-1.72.12.1-1.9-2.01.8-1.4
Tibia length10.930.241.8-6.06.55.4-5.3-5.76.1-2.6
Ambulatory time before self-admin0.30.81.6-1.11.10.6-0.6-0.81.30.2
Ambulatory time after self-admin0.40.61.20.9-1.0-0.70.60.6-1.10.1
Bone: tissue strength0.30.30.90.4-0.50.1-0.10.3-1.0-0.8
Total heroin consumption2.93.44.5-2.01.71.9-2.1-2.01.6-1.7
Bone: trabecular number0.20.40.90.4-0.7-0.80.31.0-0.40.7
Bone: trabecular spacing0.10.20.5-0.30.40.40.1-0.70.5-0.3
Bone: trabecular thickness0.20.30.60.3-0.6-0.40.10.8-0.7-0.0
Bone: trabecular tissue density0.10.20.4-0.00.3-0.10.4-0.60.60.5
Water consumed over 24 hours0.40.91.70.8-0.6-1.01.10.8-0.61.3
Number of responses in last shaping day2.22.93.6-1.81.51.9-1.7-1.51.5-1.8