Hub : Genes

Tgfbr3l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Tgfbr3l	0.1	0.07	3.7e-03	0.02	0.02	0.01	0.01	5.4e-02	6.0e-02	1.5e-01	1.0e-01
2	NAcc	gene expression	Tgfbr3l	0.05	0.03	5.3e-06	0.02	0.04	0.04	0.03	1.8e-04	4.2e-06	2.7e-06	1.1e-05
3	Brain	gene expression	Tgfbr3l	0.05	0.04	3.4e-05	0.04	0.04	0.02	0.03	1.8e-04	1.2e-04	2.8e-03	2.0e-03
4	PL	gene expression	Tgfbr3l	0.06	0.04	2.2e-08	0.06	0.06	0.05	0.06	3.3e-07	2.8e-07	2.0e-06	9.1e-07
5	BLA	gene expression	Tgfbr3l	0.06	0.05	6.6e-03	0.06	0.04	0.04	0.05	4.7e-04	6.1e-03	2.0e-03	1.1e-03
6	NAcc	isoform ratio	NM_001401205.1	0.04	0.03	5.4e-03	0.02	0.01	0	0.01	6.2e-04	3.1e-02	1.5e-01	1.8e-02
7	Liver	gene expression	Tgfbr3l	0.08	0.05	5.5e-06	0.04	0.03	0.03	0.04	8.2e-06	1.0e-04	1.3e-04	1.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	1.1	2.0	6.5	-2.6	-0.6	0.0	-0.7	1.6	1.6	1.1
Area under the delay curve	0.7	1.1	1.7	1.1	0.2	-1.3	-1.1	0.9	1.0	1.3
BMI with tail	0.8	2.6	4.6	-1.9	1.7	-0.4	-1.0	2.1	1.7	1.9
BMI without tail	0.4	2.1	10.2	-3.2	-0.4	0.7	-0.1	1.4	0.8	1.0
Body weight	2.3	10.0	53.1	-7.3	-1.9	2.4	0.6	1.9	1.6	1.1
Weight adjusted by age	0.2	0.5	1.1	-1.0	-1.1	0.8	0.6	-0.1	-0.6	-0.2
Bone surface	1.1	2.2	8.1	-2.8	-0.2	0.2	-0.6	1.6	1.6	1.1
Bone volume	1.4	2.7	5.0	-1.8	0.6	-0.7	-1.3	2.2	2.2	1.7
Breakpoint value in progressive ratio session	0.7	1.2	3.2	-0.2	1.8	-0.9	-1.1	1.2	0.9	1.0
Number of licking bursts	2.9	8.9	11.3	-1.3	-2.3	3.2	3.3	-3.3	-3.3	-3.4
Context. condit. distance diff. score	2.4	2.9	5.1	-2.1	0.3	-0.8	-1.6	2.0	2.3	2.0
Locomotion velocity, session 1	0.2	0.2	0.4	0.7	0.4	-0.6	-0.5	0.6	0.2	0.4
Locomotion distance, session 1	0.3	0.3	1.7	1.3	0.0	-0.6	-0.3	-0.1	0.1	0.4
Locomotion velocity, session 2	0.4	0.5	0.8	0.4	-0.6	0.5	0.7	-0.9	-0.8	-0.8
Locomotion distance, session 2	0.5	0.7	2.2	0.7	-1.5	0.1	0.3	-0.9	-1.1	-0.5
Locomotion velocity, session 3	0.8	0.9	1.8	-0.4	0.8	-0.7	-1.0	1.1	1.3	1.0
Locomotion distance, session 3	0.1	0.1	0.2	-0.2	0.3	-0.1	-0.2	-0.0	0.2	0.4
Stereotopy head waving bouts, day 3	0.6	0.7	2.9	-1.7	-1.0	0.9	0.5	0.0	-0.2	-0.2
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.3	-0.1	-0.1	0.0	0.3	0.0	-0.2
Locomotion velocity, session 7	0.2	0.2	0.8	0.9	-0.5	-0.5	-0.3	0.2	0.3	0.3
Locomotion distance, session 7	0.1	0.2	0.5	0.2	-0.7	-0.4	-0.4	0.1	0.5	0.4
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.5	0.3	-0.3	-0.3	0.3	-0.2	-0.0
Stereotopy head waving duration, day 7	0.1	0.2	0.8	0.9	0.1	-0.3	-0.1	0.1	-0.5	-0.2
Locomotion velocity, session 8	0.3	0.3	2.0	-0.3	-1.4	0.2	0.2	-0.1	-0.0	-0.3
Locomotion distance, session 8	0.6	0.9	2.2	-1.3	-1.5	-0.1	-0.5	0.7	1.0	0.8
Degree of sensitization distance	0.3	0.3	1.0	1.0	-0.6	-0.1	0.2	-0.4	-0.3	-0.6
Degree of sensitization stereotypy	0.3	0.4	0.6	0.7	0.8	-0.7	-0.6	0.6	0.2	0.3
Conditioned locomotion	0.9	1.1	2.9	-0.0	1.7	-0.9	-1.0	1.0	1.0	0.9
Cocaine response after cond. corrected	0.1	0.2	0.4	0.6	0.4	-0.0	0.2	0.5	0.6	-0.3
Cocaine response after cond. not corrected	0.9	1.3	2.7	0.6	0.9	-1.0	-1.0	1.6	1.6	0.9
Cocaine response before conditioning	2.8	3.4	5.7	-0.2	0.6	-2.0	-2.3	2.2	1.9	2.4
Saline control response	2.4	3.3	7.6	-2.8	-0.9	2.0	1.4	-1.6	-2.0	-1.4
Bone: connectivity density	1.4	2.3	11.7	-3.4	-1.0	0.7	-0.2	1.1	1.0	0.7
Bone: cortical apparent density	0.1	0.2	0.8	0.9	-0.4	-0.4	-0.1	0.4	0.3	0.2
Bone: cortical area	0.8	1.3	2.2	-1.5	1.5	-0.3	-0.8	1.2	1.3	1.1
Bone: cortical porosity	0.3	0.3	0.7	-0.2	-0.7	0.5	0.4	-0.4	-0.8	-0.8
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.2	-0.2	-0.2	-0.0	-0.5	-0.2
Bone: cortical thickness	0.4	0.7	2.0	-1.4	0.6	0.1	-0.3	0.8	1.0	0.6
Bone: cortical thickness	0.3	0.3	1.8	-1.4	-0.1	0.4	0.1	0.1	0.1	-0.4
Bone: cortical tissue density	0.1	0.2	0.9	1.0	-0.5	-0.3	-0.1	0.3	0.2	0.2
Condit. Reinf. active minus inactive responses	1.0	1.1	2.2	1.1	1.5	-1.1	-1.0	0.9	0.9	0.6
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.7	0.8	1.2	-1.1	-1.1	1.3	1.0	0.9
Condit. Reinf. active responses	0.8	1.0	1.8	0.8	1.3	-1.1	-1.1	0.8	0.9	0.7
Condit. Reinf. inactive responses	0.2	0.2	0.4	0.5	0.5	-0.6	-0.6	0.1	0.4	0.5
Incentive salience index mean	1.3	1.7	3.8	0.9	2.0	-1.5	-1.4	1.1	1.2	0.9
Condit. Reinf. lever presses	1.3	2.0	4.3	0.6	2.1	-1.5	-1.6	1.2	1.4	1.0
Condit. Reinf. active minus inactive responses	0.2	0.4	1.7	-1.3	-0.2	0.6	0.3	-0.3	-0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.4	0.6	-0.6	0.0	0.7	0.6	-0.7	-0.8	-0.6
Condit. Reinf. active responses	0.4	0.6	1.9	-1.4	0.8	-0.2	-0.6	0.7	0.8	0.3
Condit. Reinf. inactive responses	0.6	0.9	1.5	-0.8	0.9	-0.7	-1.1	1.1	1.2	0.6
Condit. Reinf. lever presses	1.3	1.9	2.9	-0.4	1.5	-1.2	-1.5	1.5	1.7	1.4
Condit. Reinf. lever reinforcers received	0.3	0.4	1.1	-1.1	0.6	-0.3	-0.6	0.5	0.7	0.2
Conditioned reinforcement - actives	0.4	1.5	5.6	-2.4	-0.7	1.5	1.0	-0.7	-0.4	-0.6
Conditioned reinforcement - inactives	0.5	1.4	2.0	-1.0	-0.7	1.4	1.3	-1.4	-1.1	-1.4
Conditioned locomotion	0.6	0.8	4.5	-2.1	-0.8	0.2	-0.4	0.4	0.4	0.4
Patch foraging indifference point 0 sec	0.0	0.1	0.3	-0.3	0.5	0.0	-0.1	-0.2	0.1	-0.0
Patch foraging indifference point AUC	0.7	1.8	3.7	-1.5	-1.9	1.3	1.1	-1.1	-1.0	-1.1
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	0.3	0.3	-0.3	-0.2	0.7	0.9	0.7
Delay disc. indifference point, 16s delay	0.3	0.4	1.7	0.4	-1.3	-0.5	-0.4	0.2	0.4	0.6
Delay disc. indifference point, 2s delay	5.3	5.9	8.7	2.1	3.0	-2.6	-2.4	2.3	2.4	2.2
Delay disc. indifference point, 24s delay	0.2	0.4	1.3	0.8	-1.1	-0.1	0.2	-0.5	-0.4	-0.4
Delay disc. indifference point, 4s delay	2.7	2.9	3.7	1.3	1.7	-1.9	-1.8	1.7	1.7	1.6
Delay disc. indifference point, 8s delay	0.3	0.4	1.0	0.6	0.1	-0.9	-0.8	0.4	0.4	1.0
Indifference point function ln k	0.1	0.2	0.4	-0.4	0.6	0.4	0.2	-0.4	-0.6	0.0
Indifference point function log k	0.1	0.2	0.4	-0.4	0.6	0.4	0.2	-0.4	-0.6	0.0
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.4	0.4	0.1	-0.0	-0.3	0.0	-0.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.6	-0.6	0.2	0.0	0.1	0.1	-0.0
Patch foraging total patch changes 18 sec	0.3	0.7	1.4	-0.7	-1.0	0.8	0.7	-0.9	-0.6	-1.2
Patch foraging total patch changes 24 sec	0.0	0.2	0.4	-0.5	-0.6	-0.2	-0.3	-0.4	-0.2	-0.2
Patch foraging total patch changes 6 sec	0.1	0.2	0.7	-0.8	-0.6	0.2	-0.0	-0.1	-0.0	-0.1
Patch foraging time to switch 0 sec	0.7	2.7	7.4	2.7	1.7	-1.4	-0.9	1.5	1.5	1.1
Patch foraging water rate 0 sec	0.7	2.7	9.4	-3.1	-1.2	1.6	0.9	-1.3	-1.2	-1.1
Patch foraging water rate 12 sec	0.1	0.3	1.2	-1.1	0.6	0.2	-0.2	-0.5	-0.3	0.1
Patch foraging water rate 18 sec	0.1	0.1	0.5	-0.3	0.1	-0.5	-0.7	-0.0	-0.4	0.2
Patch foraging water rate 24 sec	1.0	1.5	4.5	-2.1	-1.6	1.0	0.4	-0.6	-1.1	-0.6
Patch foraging water rate 6 sec	0.4	0.6	1.4	-1.2	0.8	-0.5	-0.9	0.5	0.6	0.7
Seeking ratio, delayed vs. immediate footshock	1.2	1.8	3.4	1.4	-0.1	0.7	1.3	-1.8	-1.4	-1.7
Distance traveled before self-admin	0.3	0.7	1.5	1.1	0.1	-1.2	-1.1	0.8	0.5	0.4
Distance traveled after self-admin	0.2	0.4	1.9	-0.1	-1.4	-0.6	-0.7	0.2	0.3	0.4
Extensor digitorum longus weight	1.2	5.0	23.5	-4.8	0.3	0.4	-0.9	1.8	2.0	1.8
Bone: elastic displacement	0.2	0.3	0.6	-0.8	-0.6	0.5	0.4	-0.3	-0.5	-0.4
Bone: elastic work	0.9	1.1	6.7	-2.6	-0.6	0.9	0.3	0.0	0.0	-0.1
Bone: endosteal estimation	0.5	1.3	3.6	-1.9	-0.3	1.3	0.9	-0.9	-0.9	-1.1
Bone: endosteal perimeter	0.3	0.7	3.1	-1.8	0.7	-0.1	-0.6	0.7	0.5	0.5
Epididymis fat weight	0.3	1.5	2.9	-0.1	0.3	-1.4	-1.5	1.7	1.4	1.1
Delta time in closed arm before/after self-admin	0.5	0.5	2.2	-0.6	-1.5	0.4	0.2	-0.2	-0.3	-0.6
Delta time in open arm before/after self-admin	3.4	4.1	14.0	2.1	3.7	-1.8	-1.4	1.2	1.3	1.4
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	-0.5	0.5	-0.2	-0.4	0.4	0.4	0.4
Delay discount exponential model param	1.1	1.5	2.3	-1.3	-0.4	1.5	1.3	-1.1	-1.1	-1.4
Extinction: sum of active levers before priming	1.2	1.8	2.9	0.7	1.7	-1.3	-1.3	1.3	1.5	1.4
Active lever presses in extinction session 6	0.3	0.3	0.8	-0.5	0.6	-0.3	-0.5	0.5	0.9	0.4
Bone: final force	1.0	1.6	5.2	-2.3	-0.4	1.6	1.2	-0.7	-0.6	-1.0
Bone: final moment	1.0	1.5	4.2	-2.1	-0.5	1.6	1.2	-0.9	-0.7	-1.1
Food consumed during 24 hour testing period	0.5	1.1	1.8	-0.7	0.1	1.2	1.2	-1.1	-1.3	-1.2
Glucose	0.6	0.9	3.6	1.9	0.2	-1.0	-0.6	0.5	0.9	0.4
Heart weight	0.7	1.2	3.0	-1.2	-1.7	0.7	0.5	-0.9	-1.0	-1.1
Delay discount hyperbolic model param	1.3	1.7	2.5	-1.3	-0.7	1.6	1.4	-1.2	-1.2	-1.5
Intermittent access intake day 1-15 change	0.4	2.0	3.3	-1.4	-0.7	1.8	1.7	-1.4	-1.2	-1.4
Intermittent access intake escalation	0.4	2.1	3.5	-1.4	-0.7	1.9	1.7	-1.5	-1.2	-1.4
Intermittent access intake escalation 2	0.5	0.8	1.4	-0.3	0.1	1.1	1.2	-1.1	-0.8	-1.1
Intermitt. access day 1 inactive lever presses	0.1	1.3	1.9	-0.6	-1.0	1.3	1.3	-1.4	-0.9	-1.2
Intermitt. access day 15 inactive lever presses	0.2	0.8	2.8	0.8	1.7	-0.3	-0.1	0.8	1.1	0.7
Intermitt. access escalation Index	0.1	0.4	1.2	0.2	0.0	-0.8	-0.9	0.4	0.3	1.1
Intermittent access day 1 total infusions	0.1	0.4	1.1	0.6	1.1	-0.7	-0.7	-0.1	0.2	0.5
Intermittent access day 15 total infusions	0.1	0.2	0.6	-0.4	0.5	0.4	0.3	-0.8	-0.4	-0.1
Intermittent access terminal intake (last 3 days)	0.1	0.2	1.0	-0.0	1.0	0.2	0.3	-0.5	-0.1	-0.1
Intermittent access total infusions	0.5	0.5	2.3	0.4	1.5	-0.6	-0.5	0.3	0.6	0.6
Intermittent access day 1 locomotion	1.1	2.0	3.1	0.8	1.3	-1.7	-1.7	1.1	1.0	1.8
Intermittent access day 15 total locomotion	0.1	0.3	0.7	-0.9	0.6	-0.4	-0.7	-0.2	0.1	0.7
Intermittent access total locomotion	1.0	1.2	2.2	0.2	1.5	-1.2	-1.4	0.7	0.9	1.1
Intermittent access standard deviation	0.1	0.5	1.2	-0.1	0.3	1.0	1.1	-0.6	-0.3	-0.7
Left kidney weight	1.2	9.9	47.4	-6.9	-3.3	3.0	1.4	0.4	0.2	0.1
Right kidney weight	1.2	8.5	36.6	-6.0	-3.4	2.9	1.6	0.1	-0.5	-0.3
Cocaine induced anxiety	0.7	1.9	3.4	0.4	1.5	-1.4	-1.5	1.4	1.9	1.2
Post-drug Anxiety	5.9	6.7	9.6	2.6	3.1	-2.5	-2.1	2.4	2.9	2.4
Baseline Anxiety	0.7	1.1	6.2	2.5	1.0	-0.5	0.1	0.4	0.1	0.6
Tail length	1.9	10.3	38.2	-6.2	-4.7	3.0	1.6	-0.1	-0.2	-0.5
Length with tail	4.4	19.6	79.6	-8.9	-5.6	4.4	2.4	-0.2	-0.1	-0.9
Length without tail	1.6	8.2	34.4	-5.9	-3.2	3.0	1.8	-0.1	0.1	-0.3
Times rat made contact with spout	1.0	1.1	2.0	-1.3	-0.1	1.2	1.0	-0.8	-1.4	-1.1
Lifetime Intake	0.6	0.7	2.8	0.8	1.7	-0.7	-0.6	0.5	0.6	0.7
Liver weight, left	2.7	4.7	7.9	-2.8	-1.7	2.8	2.3	-1.5	-1.9	-1.8
Liver weight, right	0.4	0.8	4.2	-2.0	-0.4	0.7	0.2	0.5	0.1	0.3
Locomotor activity	1.1	1.8	5.7	-2.3	-2.4	0.9	0.3	-0.3	-0.5	-0.2
Locomotor testing distance	0.6	1.6	5.7	-1.6	-2.4	1.0	0.7	-0.5	-0.8	-0.6
Locomotor testing rearing	0.0	0.1	0.2	-0.2	-0.2	-0.0	-0.1	0.4	-0.4	0.1
Locomotion in novel chamber	2.1	2.9	5.3	-1.6	-2.3	1.4	1.1	-1.7	-1.5	-2.0
Locomotion in novel chamber post-restriction	0.4	1.3	3.9	-1.7	-2.0	0.8	0.3	-1.0	-0.7	-0.6
Fecal boli incidents, locomotor time 1	0.5	1.4	5.1	-1.9	-2.3	0.7	0.2	-0.1	-0.5	-0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	0.7	0.3	0.3	0.6	-0.3	-0.2	-0.1
Time >=10cm from walls, locomotor time 1	2.4	3.0	3.9	1.3	1.3	-1.9	-1.7	2.0	1.8	1.9
Bouts of movement, locomotor time 1	1.4	1.8	8.0	-1.7	-2.8	1.0	0.6	-0.5	-0.4	-0.4
Total resting periods, locomotor time 1	1.5	1.8	8.3	-1.7	-2.9	0.8	0.4	-0.3	-0.2	-0.4
Rest time, locomotor task time 1	0.8	1.3	5.3	-1.6	-2.3	0.3	-0.1	0.5	0.5	0.6
Distance moved, locomotor task time 1	0.2	0.6	3.4	0.9	1.9	-0.3	-0.1	-0.3	-0.2	-0.2
Vertical activity count, locomotor time 1	0.0	0.2	0.6	-0.2	-0.0	0.3	0.3	-0.8	-0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.8	2.4	4.8	-0.1	0.2	-1.3	-1.5	2.2	1.8	2.1
Bouts of movement, locomotor time 2	0.2	0.8	2.1	-1.2	-1.5	-0.2	-0.6	0.8	0.5	0.9
Total resting periods, locomotor time 2	0.2	0.7	2.2	-1.2	-1.5	-0.1	-0.5	0.7	0.4	0.8
Rest time, locomotor task time 2	0.3	0.5	1.2	0.2	0.2	-0.8	-0.9	1.1	0.6	0.9
Distance moved, locomotor task time 2	1.5	2.0	3.4	-0.3	-0.9	1.5	1.7	-1.8	-1.4	-1.5
Vertical activity count, locomotor time 2	2.0	4.7	10.0	-1.8	-3.2	2.2	2.0	-2.2	-1.6	-1.8
Light reinforcement 1	0.4	1.6	2.5	1.6	1.4	-1.5	-1.2	0.7	1.1	1.3
Light reinforcement 2	0.2	0.4	0.8	0.6	-0.5	0.4	0.6	-0.9	-0.7	-0.7
Bone: marrow area	0.6	1.4	3.5	-1.9	-0.4	1.4	1.0	-1.0	-0.9	-1.1
Bone: maximum diameter	0.4	0.8	2.7	-1.6	1.1	0.1	-0.3	0.8	0.8	0.6
Bone: maximum force	0.5	1.0	5.2	-2.3	-0.5	1.1	0.6	-0.3	-0.2	-0.6
Bone: maximum moment	0.6	1.0	4.4	-2.1	-0.7	1.1	0.7	-0.4	-0.4	-0.7
Mean time between licks in bursts	0.1	0.8	2.2	1.5	1.3	-0.9	-0.6	0.2	0.2	0.7
Mean num. licks in bursts	1.0	2.7	4.0	0.3	1.6	-1.7	-1.9	2.0	1.6	1.8
Cd content in liver	0.3	0.3	0.9	-0.2	-0.0	0.2	0.1	-1.0	-0.9	-0.5
Co content in liver	3.4	4.0	6.2	-0.7	-0.9	2.0	2.1	-2.5	-2.5	-2.4
Cu content in liver	0.1	0.1	0.3	-0.2	0.6	-0.1	-0.2	-0.1	-0.4	0.3
Fe content in liver	3.9	4.9	9.4	-1.0	3.1	-1.8	-2.3	2.2	2.1	2.5
K content in liver	0.6	0.6	1.0	0.4	0.6	-0.9	-0.9	1.0	0.7	0.9
Mg content in liver	0.3	0.3	0.7	-0.4	-0.8	0.5	0.5	-0.4	-0.6	-0.3
Mn content in liver	1.1	1.2	1.6	0.4	-1.1	1.0	1.2	-1.3	-1.2	-1.3
Na content in liver	0.2	0.2	1.0	-1.0	-0.2	0.4	0.2	0.2	0.1	0.1
Rb content in liver	2.9	3.3	5.1	2.3	2.1	-2.2	-1.8	1.3	1.4	1.4
Se content in liver	6.4	7.5	11.5	-0.1	2.5	-2.5	-2.8	3.4	3.2	3.2
Sr content in liver	2.0	1.7	2.5	-0.6	-1.4	1.5	1.6	-1.4	-1.1	-1.3
Zn content in liver	1.2	1.5	5.0	-2.2	-0.7	1.4	1.0	-0.7	-0.8	-0.6
Bone: minimum diameter	0.3	0.5	2.5	0.1	1.6	0.3	0.3	-0.4	-0.5	-0.7
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.6	-0.4	0.2	0.4	0.0	-0.4	-0.6
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.6	-0.0	0.1	-0.0	0.2	0.3	0.3
Total zone transitions, hab. session 1	0.4	0.5	1.7	1.3	0.4	-1.0	-0.8	0.2	0.3	0.1
Total locomotion distance, hab. session 1	1.5	2.2	3.4	1.3	1.1	-1.8	-1.7	1.3	1.7	1.1
Locomotion velocity, hab. session 1	1.8	2.5	4.2	1.8	1.4	-2.0	-1.8	1.2	1.6	1.2
Time in familiar zone, hab. session 2	0.2	0.3	0.9	0.4	-1.0	-0.4	-0.3	0.7	0.4	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.8	0.3	0.9	-0.2	-0.1	-0.3	-0.1	0.1
Total zone transitions, hab. session 2	1.2	1.5	2.5	-0.6	-1.6	1.2	1.2	-1.3	-1.2	-1.3
Total locomotion distance, hab. session 2	0.0	0.1	0.1	0.3	0.3	-0.1	0.0	-0.4	-0.2	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.4	0.3	0.1	0.1	0.3	-0.6	-0.4	-0.5
Novel to familiar place preference ratio	0.5	0.6	1.0	0.0	-0.1	0.8	0.9	-1.0	-0.9	-0.8
Novelty place preference	0.4	0.5	0.9	0.4	-0.0	0.7	0.8	-1.0	-0.9	-0.8
Time in novel zone, NPP test	0.4	0.4	0.7	0.2	-0.5	0.7	0.8	-0.8	-0.8	-0.7
Total zone transitions, NPP test	0.1	0.2	1.2	-0.3	-1.1	0.1	0.0	-0.3	-0.2	-0.1
Total locomotion distance, NPP test	1.5	2.0	3.1	0.3	1.3	-1.5	-1.7	1.4	1.6	1.7
Locomotion velocity, NPP test	1.0	1.4	2.0	0.0	1.4	-1.2	-1.4	1.0	1.2	1.4
Intraocular pressure	0.5	0.8	3.1	-1.8	0.7	-0.2	-0.7	0.7	0.9	0.6
Delta distance traveled before/after self-admin	1.0	1.1	1.8	-1.1	-1.4	1.1	1.0	-1.2	-0.8	-0.7
Delta ambulatory time before/after self-admin	0.2	0.4	0.8	-0.2	-0.7	0.6	0.7	-0.9	-0.6	-0.5
Parametrial fat weight	0.4	1.1	2.1	0.4	1.5	-0.6	-0.5	1.2	1.2	1.3
Pavlov. Cond. lever latency	2.2	2.8	7.0	-1.9	-2.7	1.8	1.5	-0.9	-1.2	-0.9
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	-0.7	0.4	0.1	-0.1	0.2	0.3	0.6
Pavlov. Cond. change in total contacts	1.5	1.6	2.4	1.2	1.6	-1.3	-1.1	1.1	1.4	1.1
Pavlov. Cond. index score	0.8	1.0	2.4	0.5	1.6	-1.0	-1.0	0.8	1.0	0.9
Pavlov. Cond. latency score	1.1	1.4	3.2	0.7	1.8	-1.2	-1.1	0.9	1.1	1.0
Pavlov. Cond. lever contacts	2.1	2.5	6.4	1.7	2.5	-1.7	-1.4	0.9	1.2	1.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	0.5	-0.7	0.5	0.7	-0.6	-0.6	-1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	0.9	-0.7	-0.1	0.1	-0.6	-0.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.7	0.5	1.3	-1.0	-1.0	0.9	1.0	0.9
Pavlov. Cond. response bias	0.6	0.8	1.9	-0.1	1.4	-0.7	-0.9	0.7	0.8	0.9
Pavlov. Cond. lever latency	1.1	1.6	2.4	-0.4	-1.6	1.4	1.4	-1.2	-1.4	-1.1
Pavlov. Cond. magazine entry latency	1.7	2.5	3.4	1.7	1.8	-1.8	-1.6	1.3	1.5	1.1
Pavlov. Cond. change in total contacts	0.2	0.5	1.3	0.2	1.1	-0.7	-0.8	0.3	0.6	0.7
Pavlov. Cond. index score	1.1	1.7	2.5	1.1	1.6	-1.6	-1.5	1.0	1.2	1.0
Pavlov. Cond. latency score	1.1	1.8	2.6	1.1	1.6	-1.6	-1.5	1.1	1.4	1.0
Pavlov. Cond. lever contacts	1.6	2.4	3.6	0.6	1.9	-1.7	-1.8	1.5	1.7	1.5
Pavlov. Cond. magazine entry number	1.0	1.3	2.2	-1.5	-1.3	1.4	1.2	-0.6	-0.9	-0.7
Pavlov. Cond. intertrial magazine entries	0.4	1.0	2.1	-1.4	-0.9	1.1	0.8	-0.7	-1.0	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.6	2.8	1.1	1.7	-1.5	-1.4	0.8	1.1	0.9
Pavlov. Cond. response bias	2.5	3.5	5.6	1.0	2.4	-2.1	-2.1	1.6	1.9	1.6
Time in closed arm before self-admin	1.8	3.2	5.2	-1.7	-2.3	1.9	1.7	-1.9	-1.4	-1.4
Time in closed arm after self-admin	4.2	4.8	11.9	-2.0	-3.5	2.0	1.6	-2.0	-1.8	-2.0
Time in open arm before self-admin	0.1	0.1	0.2	-0.1	-0.5	-0.2	-0.3	0.1	0.0	0.4
Time in open arm after self-admin	3.6	4.0	11.8	1.6	3.4	-1.7	-1.5	1.6	1.6	1.8
Bone: periosteal estimation	0.4	0.8	4.7	-2.2	0.5	0.8	0.3	0.0	0.0	-0.2
Bone: periosteal perimeter	1.0	2.0	3.5	-1.2	1.9	-1.0	-1.4	1.5	1.4	1.4
Bone: post-yield work	0.4	0.7	1.0	-0.7	0.6	-0.7	-1.0	1.0	1.0	0.8
Progressive ratio test 1 active lever presses	0.3	0.5	1.2	-1.1	-0.8	0.8	0.6	-0.5	-0.5	-0.4
Progressive ratio test 1 breakpoint	0.3	0.5	1.2	-1.1	-0.9	0.8	0.6	-0.5	-0.5	-0.4
Progressive ratio test 1 inactive lever presses	0.8	2.2	2.6	-1.3	-1.4	1.6	1.4	-1.6	-1.5	-1.5
Progressive ratio test 2 active lever presses	0.9	1.3	2.1	-1.3	-0.3	1.4	1.2	-1.4	-1.0	-1.0
Progressive ratio test 2 breakpoint	1.0	1.3	2.1	-1.3	-0.3	1.4	1.2	-1.4	-1.0	-1.0
Progressive ratio test 2 inactive lever presses	0.8	2.5	6.0	-2.4	-1.3	1.8	1.2	-1.3	-1.2	-1.3
Incentive Sensitization - Responses	0.1	0.3	0.6	-0.0	0.8	0.5	0.6	-0.8	-0.4	-0.3
Incentive Sensitization - Breakpoint	0.1	0.3	0.8	0.0	0.9	0.4	0.5	-0.8	-0.4	-0.2
Sum of active levers in priming session hrs 5-6	2.0	1.9	4.3	0.4	2.0	-0.9	-0.9	1.3	2.1	1.3
Progressive ratio	0.3	0.9	2.0	0.8	0.4	0.6	1.0	-1.1	-1.4	-1.2
Food seeking constrained by brief footshock	0.5	0.6	3.0	1.0	1.7	-0.0	0.2	-0.3	-0.4	-0.3
Seeking ratio, punishment vs. effort	0.1	0.2	0.7	-0.8	-0.1	0.1	-0.2	0.3	0.6	0.5
Retroperitoneal fat weight	1.2	5.4	9.4	1.3	1.4	-2.5	-2.4	3.1	2.7	2.4
Reaction time number correct	0.3	1.0	2.1	-1.4	-0.5	1.2	0.9	-1.1	-0.9	-0.8
Reaction time mean minus median	0.5	3.3	5.6	-0.1	0.7	-1.9	-2.3	2.3	1.7	2.4
Reaction time mean minus median AUC	0.2	1.2	2.3	0.4	0.3	-1.4	-1.5	1.2	0.8	1.5
Reaction time num false alarms	0.3	0.5	0.9	0.1	0.5	-0.8	-1.0	0.7	0.5	0.9
Reaction time num false alarms AUC	0.4	0.8	1.6	-0.1	0.6	-1.0	-1.2	1.0	0.8	1.1
Reaction time trials correct on left	0.3	1.0	2.1	-1.4	-0.5	1.2	0.9	-1.1	-0.9	-0.8
Reaction time trials on left	0.3	0.9	2.0	-1.4	-0.4	1.1	0.9	-1.0	-0.9	-0.8
Reaction time mean	0.9	2.0	5.8	2.4	0.2	-1.7	-1.3	1.2	0.8	1.2
Reaction time mean AUC	0.9	2.2	5.6	2.4	0.3	-1.8	-1.4	1.3	0.9	1.3
Median of all reaction times	1.1	1.7	8.7	2.9	-0.1	-1.4	-0.7	0.7	0.4	0.6
Reaction time omissions	0.9	1.4	2.2	1.1	0.6	-1.4	-1.4	1.3	0.6	1.5
Reaction time false alarm rate	1.2	1.7	2.7	0.5	0.6	-1.5	-1.7	1.5	1.2	1.5
Reaction time premature initiation rate	0.1	0.2	0.3	0.2	0.6	-0.5	-0.5	0.3	0.3	0.1
Reaction time premature initiations	0.0	0.1	0.4	-0.3	0.6	-0.0	-0.1	-0.1	-0.0	-0.2
Std. dev. reaction times	0.8	2.7	3.9	1.0	0.9	-1.9	-1.9	1.9	1.5	2.0
Reaction time trials completed	0.3	0.9	2.0	-1.4	-0.4	1.1	0.9	-1.0	-0.9	-0.8
Reaction time trials AUC	0.2	0.6	1.5	-1.2	-0.2	0.9	0.7	-0.9	-0.7	-0.6
Run reversals in cocaine runway, females	0.6	0.6	0.9	1.0	0.0	-1.0	-0.8	0.7	0.8	0.9
Run reversals in cocaine runway, males	0.9	1.0	2.0	-0.4	-0.7	0.8	0.8	-1.2	-1.4	-1.1
Latency to leave start box in cocaine runway	0.1	0.1	0.4	0.5	-0.7	0.2	0.4	-0.0	-0.0	0.1
Latency to leave start box in cocaine runway, F	0.5	0.7	1.9	-0.0	-1.4	1.0	1.2	-0.5	-0.2	-0.4
Latency to leave start box in cocaine runway, M	0.3	0.3	0.5	0.6	0.7	-0.7	-0.7	0.3	0.1	0.7
Std. dev. time between licks in bursts	0.1	0.2	0.7	-0.7	0.3	-0.2	-0.5	0.2	0.1	0.8
Total sessions with >9 infusions	0.1	0.1	0.6	0.8	0.2	-0.1	0.1	0.0	-0.2	-0.1
Short access day 1 total inactive lever presses	0.1	0.2	0.5	-0.1	0.1	0.5	0.5	-0.1	-0.7	-0.4
Short access day 10 total inactive lever presses	0.1	1.0	2.2	-1.2	-0.8	1.5	1.3	-0.4	-0.7	-0.5
Short access day 1 total infusions	0.3	0.6	2.3	1.5	1.2	-0.6	-0.3	0.5	0.1	0.3
Short access day 10 total infusions	1.2	1.9	4.8	0.9	2.2	-1.3	-1.2	1.2	1.1	1.4
Short access total infusions	0.8	1.1	2.9	1.6	1.7	-0.9	-0.6	0.9	0.6	0.7
Short access day 1 locomotion	0.2	0.4	0.8	0.6	0.2	-0.9	-0.9	0.6	0.2	0.2
Short access day 10 total locomotion	0.0	0.0	0.3	-0.1	0.1	0.0	-0.1	0.0	-0.5	0.1
Short access total locomotion	0.6	0.9	1.3	1.1	0.8	-1.2	-1.0	1.0	0.5	0.9
One hour access (0.3 mA shock)	2.2	2.6	3.8	-1.8	-0.7	1.7	1.4	-2.0	-1.7	-1.6
Compulsive drug intake	0.3	0.5	1.7	1.3	-0.8	-0.3	0.1	-0.6	-0.7	-0.4
One hour access (shock baseline)	0.3	0.7	3.6	-1.9	0.3	0.8	0.3	-0.5	-0.3	-0.4
Social response proportion	1.6	2.0	5.5	-2.3	-1.3	1.7	1.2	-1.0	-0.5	-1.2
Social responses	0.5	0.6	4.0	-2.0	-0.3	0.4	-0.1	-0.1	0.1	0.0
Social time	0.4	0.6	2.8	1.7	-0.0	-0.4	0.0	-0.5	-0.8	-0.6
Soleus weight	0.7	2.1	5.7	-2.4	1.5	-0.3	-1.0	1.2	1.5	1.5
Bone: stiffness	0.1	0.3	1.3	-1.2	0.6	0.3	-0.0	-0.0	0.1	-0.1
Tibialis anterior weight	1.5	5.1	24.3	-4.9	-0.3	0.7	-0.6	1.9	2.0	1.6
Time to tail flick, vehicle, before self-admin	0.5	0.7	1.7	1.3	0.5	-0.8	-0.5	0.5	0.9	0.9
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	-0.2	0.2	-0.1
Time to tail flick, test, before self-admin	2.7	3.1	10.4	-1.6	-3.2	1.7	1.5	-1.2	-1.1	-0.9
Time to tail flick, test, after self-admin	0.6	0.6	2.0	1.0	1.4	-0.4	-0.2	0.3	1.0	0.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.3	0.1	0.2	-0.1
Delta time to tail flick, test, before/after SA	2.3	2.9	11.7	1.6	3.4	-1.4	-1.1	0.9	1.1	0.7
Tibia length	2.6	7.2	13.1	-3.6	-2.8	3.3	2.8	-1.7	-1.6	-2.2
Ambulatory time before self-admin	0.4	1.3	2.6	0.6	0.3	-1.6	-1.6	1.4	1.0	0.9
Ambulatory time after self-admin	0.4	0.6	1.1	0.1	-0.7	-1.0	-1.0	0.7	0.6	0.8
Bone: tissue strength	0.6	0.6	2.7	-0.2	-1.6	0.7	0.8	-0.6	-0.5	-0.3
Total heroin consumption	4.3	5.1	11.8	1.7	3.4	-2.4	-2.2	1.8	2.1	1.6
Bone: trabecular number	0.8	1.6	5.5	-2.3	-1.3	0.2	-0.4	1.3	1.3	0.8
Bone: trabecular spacing	1.1	1.5	5.7	2.4	1.9	-0.9	-0.4	-0.4	-0.4	-0.0
Bone: trabecular thickness	1.7	2.4	4.9	-2.2	0.1	-0.5	-1.2	1.9	2.0	1.5
Bone: trabecular tissue density	0.6	1.1	1.7	0.3	0.2	-1.1	-1.2	1.2	1.3	1.3
Water consumed over 24 hours	2.6	5.1	6.8	-2.3	-1.6	2.6	2.3	-2.0	-2.5	-2.3
Number of responses in last shaping day	0.2	0.2	0.5	0.7	0.7	-0.4	-0.3	0.4	0.1	0.3