Hub : Genes

Tepsin

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA alternative TSS XM_006247895.5 0.06 0.05 6.4e-04 0.04 0.04 0.05 0.04 6.5e-04 2.9e-04 1.4e-04 2.7e-04
2 NAcc alternative TSS NM_001100729.1 0.03 0.02 1.1e-04 0.01 0.02 0.01 0.02 4.6e-03 2.9e-04 2.5e-03 2.8e-04
3 OFC mRNA stability Tepsin 0.29 0.23 7.5e-03 0.09 0.05 0.07 0.07 3.7e-03 2.0e-02 9.6e-03 9.4e-03
4 NAcc alternative TSS XM_006247895.5 0.03 0.02 4.2e-04 0.02 0.02 0.02 0.02 1.1e-03 2.1e-04 6.0e-04 1.0e-03
5 PL alternative TSS XM_006247895.5 0.04 0.03 9.1e-05 0.04 0.03 0.03 0.04 1.9e-05 2.0e-04 2.2e-04 6.5e-05
6 Brain alternative TSS NM_001100729.1 0.07 0.05 5.1e-05 0.04 0.04 0.04 0.03 1.5e-04 1.1e-04 3.0e-04 4.8e-04
7 Brain alternative TSS XM_006247895.5 0.07 0.05 6.8e-05 0.04 0.04 0.04 0.04 6.9e-05 5.2e-05 2.0e-04 2.4e-04
8 NAcc gene expression Tepsin 0.13 0.07 1.7e-12 0.08 0.08 0.08 0.09 3.1e-12 2.1e-12 3.3e-12 5.5e-13
9 PL alternative TSS NM_001100729.1 0.03 0.02 4.1e-03 0.02 0.01 0.01 0.01 3.5e-03 1.5e-02 1.0e-02 1.3e-02
10 pVTA alternative TSS NM_001100729.1 0.08 0.05 1.4e-04 0.06 0.05 0.05 0.05 2.4e-05 1.1e-04 6.9e-05 7.0e-05
11 Adipose intron excision ratio chr10_105876056_105876909 0.03 0.02 2.4e-03 0.03 0.02 0.02 0.03 5.4e-04 3.0e-03 4.5e-03 8.1e-04
12 Brain intron excision ratio chr10_105876056_105876909 0.03 0.03 8.4e-03 0.01 0.02 0.02 0.02 1.4e-02 5.8e-03 6.5e-03 8.0e-03
13 Adipose mRNA stability Tepsin 0.14 0.1 1.3e-10 0.09 0.09 0.08 0.09 2.7e-10 2.4e-10 5.4e-09 5.3e-10
14 RMTg mRNA stability Tepsin 0.19 0.12 5.2e-03 0.05 0.09 0.06 0.08 1.7e-02 2.2e-03 1.0e-02 4.0e-03
15 BLA mRNA stability Tepsin 0.09 0.07 4.1e-03 0.03 0.02 0.01 0.03 6.4e-03 3.0e-02 7.3e-02 1.6e-02
16 Liver gene expression Tepsin 0.04 0.03 9.8e-04 0.02 0.02 0.01 0.02 1.7e-03 1.9e-03 1.5e-02 5.3e-03
17 NAcc mRNA stability Tepsin 0.18 0.13 3.2e-06 0.03 0.03 0.02 0.03 1.2e-05 7.3e-06 3.8e-04 2.7e-05
18 Adipose alternative TSS XM_039086442.2 0.03 0.03 3.2e-03 0.01 0.02 0.01 0.01 4.8e-02 2.9e-03 9.4e-03 2.3e-02
19 Liver mRNA stability Tepsin 0.06 0.04 4.2e-05 0.02 0.04 0.04 0.04 3.5e-03 2.2e-05 6.5e-05 6.9e-05
20 LHb mRNA stability Tepsin 0.54 0.29 1.3e-03 0.05 0.05 0.05 0.07 2.7e-02 2.7e-02 2.5e-02 1.1e-02
21 Brain mRNA stability Tepsin 0.37 0.12 0.0e+00 0.24 0.26 0.25 0.25 4.4e-22 9.1e-24 1.3e-23 3.5e-23
22 BLA gene expression Tepsin 0.13 0.08 2.0e-04 0.02 0.05 0.04 0.03 2.2e-02 1.0e-03 3.5e-03 9.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.10.20.7-0.40.80.1-0.6-0.50.6-0.60.70.70.80.00.30.20.30.10.50.00.40.40.50.20.3
Area under the delay curve0.70.92.11.3-1.20.91.00.9-1.01.0-0.9-1.0-1.01.40.90.80.91.40.90.80.50.40.10.70.4
BMI with tail0.62.25.2-1.61.80.4-1.9-2.32.2-2.22.32.11.60.70.70.70.80.70.71.01.11.21.41.21.4
BMI without tail1.44.412.4-2.93.5-0.8-3.3-3.03.4-3.33.23.12.9-0.10.00.30.1-0.3-0.80.50.81.00.70.61.0
Body weight1.25.215.8-4.03.8-2.3-3.2-2.63.2-3.12.82.72.2-2.0-1.6-1.3-1.6-1.9-2.3-0.9-0.6-0.4-0.7-1.0-0.5
Weight adjusted by age1.31.95.1-2.22.1-0.6-2.0-1.31.9-1.81.91.81.3-1.4-1.0-0.7-1.1-1.4-1.7-0.2-0.4-0.3-0.5-0.8-0.4
Bone surface0.30.51.2-0.60.4-0.90.00.5-0.20.2-0.4-0.30.0-1.1-0.8-0.8-0.8-1.0-0.8-1.1-0.7-0.7-0.9-1.0-1.0
Bone volume0.10.20.5-0.70.7-0.4-0.4-0.10.4-0.30.30.30.4-0.5-0.3-0.3-0.3-0.4-0.3-0.5-0.2-0.2-0.2-0.4-0.3
Breakpoint value in progressive ratio session0.30.31.1-0.60.10.5-0.4-0.61.0-1.00.80.7-0.80.1-0.4-0.7-0.30.10.20.2-0.4-0.40.70.50.6
Number of licking bursts0.10.10.5-0.20.6-0.6-0.5-0.30.2-0.20.1-0.00.7-0.4-0.00.1-0.1-0.4-0.5-0.20.20.2-0.4-0.3-0.2
Context. condit. distance diff. score2.73.24.90.01.81.5-2.0-2.21.9-1.92.22.22.11.21.71.71.71.31.41.62.02.12.11.71.9
Locomotion velocity, session 12.22.46.41.2-2.3-0.52.42.5-2.32.3-2.2-2.2-1.9-0.1-0.6-0.9-0.6-0.0-0.2-1.0-1.2-1.4-1.3-0.8-1.2
Locomotion distance, session 11.51.95.72.4-1.21.70.80.6-0.90.8-0.4-0.40.11.91.71.71.71.81.71.61.41.31.11.51.1
Locomotion velocity, session 22.32.77.32.5-2.70.82.62.4-2.72.7-2.5-2.5-1.60.60.30.20.30.60.7-0.2-0.3-0.5-0.7-0.2-0.6
Locomotion distance, session 20.60.81.61.3-0.21.2-0.1-0.2-0.0-0.00.30.20.81.11.21.31.21.00.91.11.21.10.91.01.0
Locomotion velocity, session 31.01.13.21.2-1.80.11.71.6-1.61.6-1.5-1.5-1.40.4-0.1-0.2-0.10.40.1-0.2-0.6-0.7-0.5-0.2-0.5
Locomotion distance, session 31.31.43.92.0-1.91.21.61.3-1.51.5-1.2-1.2-1.11.31.00.71.01.31.20.70.40.30.40.80.5
Stereotopy head waving bouts, day 30.60.71.80.6-1.2-0.11.11.1-1.11.1-1.2-1.3-1.4-0.3-0.4-0.5-0.5-0.40.1-0.5-0.7-0.7-0.3-0.5-0.7
Stereotopy head waving duration, day 30.20.30.90.7-0.90.30.80.8-0.80.8-0.8-0.9-0.7-0.0-0.0-0.1-0.1-0.10.4-0.1-0.2-0.30.2-0.2-0.2
Locomotion velocity, session 70.40.51.21.0-0.71.10.40.2-0.40.3-0.2-0.2-0.10.90.80.70.80.91.00.70.60.50.70.80.7
Locomotion distance, session 73.34.29.62.6-0.83.10.2-0.5-0.20.10.40.30.82.62.72.52.72.72.72.42.42.22.22.52.3
Stereotopy head waving bouts, day 70.10.10.5-0.70.5-0.3-0.5-0.40.6-0.60.50.60.0-0.1-0.2-0.2-0.2-0.2-0.10.0-0.1-0.00.20.00.1
Stereotopy head waving duration, day 70.30.30.8-0.70.5-0.9-0.4-0.00.3-0.20.00.00.1-0.9-0.7-0.5-0.7-0.9-0.6-0.5-0.5-0.4-0.1-0.7-0.6
Locomotion velocity, session 81.41.73.11.3-0.01.6-0.4-0.70.3-0.30.60.61.01.51.61.71.61.41.71.61.61.61.71.51.4
Locomotion distance, session 84.46.49.70.91.82.5-2.3-2.62.1-2.22.62.52.92.22.72.92.72.22.32.73.13.13.02.62.8
Degree of sensitization distance1.31.32.9-0.31.31.0-1.5-1.71.4-1.41.51.41.50.40.90.90.90.40.71.01.21.21.40.91.1
Degree of sensitization stereotypy0.40.41.2-0.60.80.1-0.9-1.01.0-1.11.01.10.50.20.20.20.20.20.20.50.40.40.60.40.6
Conditioned locomotion2.22.67.5-1.92.7-0.4-2.6-2.32.5-2.52.42.42.1-0.40.20.40.2-0.30.20.40.91.01.50.40.8
Cocaine response after cond. corrected0.10.10.7-0.1-0.60.10.4-0.0-0.1-0.00.0-0.0-0.80.60.0-0.20.10.70.10.3-0.2-0.20.10.50.3
Cocaine response after cond. not corrected0.30.31.30.6-1.20.30.90.5-0.70.6-0.5-0.5-1.00.80.2-0.00.20.90.30.2-0.1-0.20.00.40.2
Cocaine response before conditioning0.30.41.81.3-0.70.70.60.6-0.90.9-0.8-0.70.10.30.50.60.40.40.50.10.40.30.1-0.0-0.1
Saline control response1.01.34.3-1.92.1-1.3-1.7-1.31.6-1.51.31.31.3-1.1-0.7-0.5-0.8-0.9-0.9-0.6-0.2-0.1-0.2-0.7-0.4
Bone: connectivity density0.10.20.80.40.30.6-0.3-0.10.1-0.00.10.00.80.00.60.60.50.20.90.10.70.60.70.20.3
Bone: cortical apparent density1.11.53.71.9-1.91.31.61.0-1.51.4-1.1-1.2-1.31.41.00.81.01.41.70.80.50.31.01.00.6
Bone: cortical area2.74.112.6-3.52.6-2.7-1.9-1.11.9-1.81.31.40.9-2.4-2.2-2.0-2.2-2.4-2.7-1.9-1.5-1.3-1.3-1.9-1.5
Bone: cortical porosity2.42.55.2-1.5-0.4-1.80.80.9-0.50.5-0.9-0.8-1.9-1.6-2.1-2.3-2.0-1.7-1.7-1.8-2.2-2.2-1.7-1.7-1.7
Bone: cortical porosity1.92.14.4-1.90.1-1.70.30.40.0-0.0-0.4-0.3-1.5-1.6-2.0-2.1-1.9-1.6-1.6-1.6-1.9-1.9-1.4-1.5-1.4
Bone: cortical thickness2.74.413.5-3.72.0-2.9-1.4-0.71.5-1.40.70.70.2-2.7-2.6-2.4-2.6-2.7-2.8-2.1-2.0-1.8-1.3-2.1-1.7
Bone: cortical thickness0.60.72.6-1.61.0-1.1-0.8-0.61.0-1.00.80.90.2-0.6-0.8-0.8-0.8-0.7-1.1-0.4-0.6-0.5-0.4-0.4-0.3
Bone: cortical tissue density1.21.74.22.0-2.01.31.71.1-1.61.5-1.2-1.3-1.41.41.00.71.01.41.80.80.40.31.00.90.6
Condit. Reinf. active minus inactive responses1.01.13.0-1.71.7-0.6-1.7-1.51.7-1.71.51.61.2-0.4-0.3-0.2-0.3-0.4-0.60.00.10.20.40.00.3
Condit. Reinf. active-inactive response ratio0.60.71.9-1.21.1-0.0-1.2-1.31.4-1.41.31.30.8-0.00.00.00.1-0.0-0.10.30.30.40.60.40.6
Condit. Reinf. active responses1.62.05.9-2.32.4-1.0-2.2-1.92.2-2.11.92.01.7-0.9-0.6-0.3-0.6-0.9-0.9-0.20.10.20.3-0.30.1
Condit. Reinf. inactive responses0.30.41.3-1.01.2-0.5-1.0-0.81.0-0.90.80.90.7-0.4-0.3-0.2-0.3-0.5-0.4-0.2-0.00.10.1-0.3-0.1
Incentive salience index mean0.80.92.7-1.61.6-0.7-1.6-1.21.5-1.51.21.31.3-0.6-0.4-0.2-0.4-0.6-0.7-0.10.10.20.2-0.20.0
Condit. Reinf. lever presses0.20.30.80.10.50.4-0.7-0.60.5-0.50.40.50.90.30.50.60.40.20.20.60.70.70.60.30.4
Condit. Reinf. active minus inactive responses0.20.20.8-0.60.9-0.2-0.9-0.70.7-0.70.60.50.6-0.5-0.10.1-0.1-0.5-0.30.10.20.20.4-0.10.1
Condit. Reinf. active-inactive response ratio1.01.22.8-1.71.0-1.4-0.8-0.30.7-0.60.30.30.2-1.6-1.3-1.2-1.4-1.6-1.4-1.0-1.0-0.9-0.7-1.3-1.0
Condit. Reinf. active responses0.60.82.00.10.51.0-0.8-1.10.8-0.90.90.90.60.70.90.90.90.51.01.11.01.01.41.01.1
Condit. Reinf. inactive responses1.52.04.31.3-0.42.0-0.0-0.70.2-0.30.60.60.11.91.71.51.71.72.11.81.51.41.91.81.7
Condit. Reinf. lever presses1.82.54.00.11.11.7-1.4-1.91.6-1.71.81.81.01.31.41.41.51.41.61.81.61.62.01.81.9
Condit. Reinf. lever reinforcers received1.52.14.60.20.71.6-1.2-1.71.3-1.41.51.50.81.31.41.41.41.11.61.71.51.52.11.71.8
Conditioned reinforcement - actives0.10.10.90.10.20.9-0.3-0.50.1-0.10.1-0.00.30.00.30.40.3-0.00.30.50.40.40.40.10.3
Conditioned reinforcement - inactives0.30.51.3-1.11.1-0.7-0.9-1.00.8-0.81.00.90.7-0.8-0.4-0.3-0.4-0.8-0.60.1-0.1-0.1-0.1-0.4-0.1
Conditioned locomotion0.10.20.8-0.40.50.1-0.7-0.90.5-0.50.40.30.3-0.30.10.30.0-0.40.00.70.30.40.60.00.3
Patch foraging indifference point 0 sec0.20.31.2-0.30.50.3-0.5-0.90.7-0.80.60.60.30.30.20.10.20.30.80.40.30.31.10.50.6
Patch foraging indifference point AUC0.10.10.20.30.20.2-0.3-0.40.3-0.30.40.40.20.20.30.40.30.20.00.40.40.40.20.30.4
Delay disc. indifference point, 0s delay0.10.10.3-0.10.40.5-0.4-0.30.3-0.30.20.20.20.00.10.20.00.0-0.00.40.20.20.10.00.1
Delay disc. indifference point, 16s delay2.02.14.71.6-0.31.90.0-0.1-0.10.00.30.30.52.21.91.91.92.21.91.81.71.71.41.71.6
Delay disc. indifference point, 2s delay0.10.20.70.1-0.70.30.60.7-0.60.6-0.5-0.5-0.80.30.0-0.0-0.00.30.20.3-0.2-0.2-0.20.0-0.1
Delay disc. indifference point, 24s delay2.12.36.81.9-2.60.42.42.0-2.42.3-2.1-2.1-2.21.40.40.20.41.30.30.2-0.3-0.5-1.00.2-0.3
Delay disc. indifference point, 4s delay0.30.41.30.7-0.81.00.70.6-0.70.7-0.9-1.1-1.10.40.1-0.00.10.40.40.1-0.1-0.20.10.1-0.1
Delay disc. indifference point, 8s delay0.60.82.00.5-1.3-0.21.31.3-1.31.3-1.2-1.3-1.40.5-0.2-0.3-0.20.5-0.4-0.3-0.5-0.6-1.1-0.2-0.5
Indifference point function ln k0.40.72.01.1-0.81.40.6-0.0-0.40.4-0.2-0.3-0.21.11.00.81.01.11.40.70.70.60.90.90.8
Indifference point function log k0.40.72.01.1-0.81.40.6-0.0-0.40.4-0.2-0.3-0.21.11.00.81.01.11.40.70.70.60.90.90.8
Patch foraging total patch changes 0 sec0.40.72.3-0.30.60.6-0.8-1.31.0-1.10.90.90.40.60.50.40.50.71.10.80.60.61.50.91.0
Patch foraging total patch changes 12 sec0.00.00.20.10.1-0.10.0-0.10.1-0.20.00.0-0.4-0.2-0.3-0.4-0.3-0.30.1-0.1-0.3-0.30.3-0.1-0.0
Patch foraging total patch changes 18 sec1.31.94.11.00.61.7-0.8-1.20.9-1.01.21.21.01.51.51.41.51.51.81.61.51.52.01.71.7
Patch foraging total patch changes 24 sec0.50.82.6-0.91.4-0.5-1.4-1.41.5-1.51.51.61.0-0.1-0.00.1-0.0-0.2-0.40.60.30.40.40.30.5
Patch foraging total patch changes 6 sec0.30.51.1-0.60.3-1.1-0.3-0.10.3-0.20.10.1-0.3-0.9-1.0-0.9-1.0-0.9-0.8-0.7-0.8-0.8-0.4-0.8-0.7
Patch foraging time to switch 0 sec0.20.51.90.9-1.00.11.01.4-1.11.1-1.0-0.8-0.80.30.0-0.10.00.20.1-0.3-0.2-0.3-0.7-0.2-0.4
Patch foraging water rate 0 sec1.43.09.0-1.72.40.2-2.6-3.02.7-2.72.62.51.90.00.40.60.40.00.31.21.01.11.70.91.3
Patch foraging water rate 12 sec1.43.05.6-0.21.21.7-1.7-2.41.8-1.91.91.71.41.41.51.61.61.31.61.91.81.82.41.82.1
Patch foraging water rate 18 sec1.32.15.0-0.71.70.8-2.0-2.21.9-1.91.81.61.90.40.91.20.90.30.71.41.41.51.61.11.4
Patch foraging water rate 24 sec5.27.316.1-1.22.81.8-3.3-4.03.5-3.53.63.42.81.61.92.01.91.51.72.62.52.63.22.52.9
Patch foraging water rate 6 sec0.60.92.50.20.91.3-1.0-1.61.0-1.00.90.71.00.30.80.90.80.30.81.01.01.01.30.81.0
Seeking ratio, delayed vs. immediate footshock0.50.61.6-1.31.30.2-1.0-0.40.9-0.80.91.10.8-0.6-0.6-0.5-0.6-0.6-1.0-0.5-0.3-0.2-0.5-0.5-0.5
Distance traveled before self-admin0.40.51.6-1.30.9-0.3-0.9-0.91.1-1.20.91.00.4-0.4-0.7-0.7-0.6-0.4-0.8-0.2-0.5-0.4-0.1-0.2-0.0
Distance traveled after self-admin1.41.73.6-0.81.50.7-1.6-1.81.8-1.91.71.91.40.80.70.80.80.80.81.11.01.11.51.21.4
Extensor digitorum longus weight0.93.75.00.01.41.8-1.8-2.11.8-1.92.22.22.11.61.91.92.01.71.81.92.22.22.22.12.2
Bone: elastic displacement0.60.62.8-1.70.9-1.0-0.8-0.90.9-0.90.60.50.2-0.9-0.9-0.9-0.9-0.8-0.4-0.5-0.6-0.60.2-0.5-0.3
Bone: elastic work3.84.916.5-4.11.8-3.2-1.2-0.81.5-1.50.70.7-0.3-2.7-2.9-2.9-2.8-2.6-2.4-2.3-2.4-2.2-1.2-2.1-1.8
Bone: endosteal estimation0.40.81.30.60.61.0-0.7-0.70.6-0.71.01.11.01.01.11.11.11.00.61.01.21.20.41.01.0
Bone: endosteal perimeter0.51.02.3-1.21.1-1.3-0.60.00.5-0.40.30.40.3-1.1-1.1-1.0-1.1-1.1-1.5-1.2-0.8-0.8-1.5-1.1-1.0
Epididymis fat weight0.93.08.2-2.02.60.2-2.7-2.72.9-2.92.72.61.90.10.30.40.40.1-0.10.81.01.11.10.81.2
Delta time in closed arm before/after self-admin0.20.20.90.90.3-0.1-0.30.1-0.30.4-0.3-0.30.9-0.90.20.40.0-0.90.0-0.10.30.40.0-0.6-0.4
Delta time in open arm before/after self-admin0.30.30.8-0.20.30.7-0.4-0.60.6-0.60.60.50.30.90.40.50.40.80.10.80.40.50.30.70.6
Diff in mean of infusions in LGA sessions0.10.20.4-0.50.1-0.4-0.10.10.2-0.20.20.3-0.5-0.3-0.6-0.6-0.5-0.3-0.6-0.2-0.5-0.5-0.4-0.3-0.3
Delay discount exponential model param1.11.22.7-1.51.7-0.9-1.5-1.31.5-1.41.31.41.4-1.4-0.7-0.6-0.7-1.4-0.8-0.6-0.2-0.10.2-0.6-0.2
Extinction: sum of active levers before priming0.20.20.70.2-0.80.50.60.3-0.40.4-0.3-0.6-0.70.40.30.10.30.30.90.30.10.00.60.40.4
Active lever presses in extinction session 60.60.64.10.2-1.3-0.41.00.6-0.50.5-0.6-0.8-2.0-0.1-0.8-1.0-0.7-0.1-0.3-0.0-1.1-1.1-0.4-0.2-0.3
Bone: final force2.33.711.7-3.42.9-2.2-2.4-1.82.5-2.42.02.01.5-1.9-1.7-1.5-1.6-1.9-2.1-1.2-0.9-0.7-0.6-1.2-0.8
Bone: final moment2.74.314.4-3.83.0-2.5-2.5-1.92.6-2.52.12.11.4-2.1-2.0-1.8-1.9-2.0-2.3-1.4-1.2-1.0-0.7-1.4-0.9
Food consumed during 24 hour testing period0.30.51.4-0.80.8-0.6-1.0-1.11.2-1.21.00.90.3-0.10.00.10.1-0.00.30.60.30.31.10.40.6
Glucose5.28.224.42.0-4.70.24.64.1-4.14.0-4.0-4.0-4.90.2-1.2-1.8-1.10.30.0-1.4-2.4-2.7-1.7-0.9-1.7
Heart weight0.30.41.6-1.30.6-0.9-0.7-0.60.9-0.90.70.80.0-0.1-0.6-0.6-0.6-0.2-0.6-0.1-0.5-0.4-0.2-0.1-0.1
Delay discount hyperbolic model param1.01.12.5-1.31.6-0.8-1.5-1.31.4-1.31.21.41.5-1.3-0.6-0.5-0.6-1.3-0.8-0.5-0.1-0.00.2-0.6-0.2
Intermittent access intake day 1-15 change0.10.30.9-1.0-0.10.10.1-0.00.3-0.30.20.2-0.3-0.5-0.7-1.0-0.6-0.4-0.3-0.9-0.8-0.8-0.3-0.3-0.3
Intermittent access intake escalation0.10.20.8-0.9-0.10.10.10.00.2-0.20.10.2-0.2-0.5-0.6-0.9-0.5-0.4-0.3-0.9-0.7-0.7-0.2-0.3-0.2
Intermittent access intake escalation 20.70.82.5-1.20.1-0.4-0.0-0.10.5-0.40.30.4-0.3-1.2-1.3-1.6-1.2-1.1-0.8-1.4-1.2-1.2-0.6-0.8-0.7
Intermitt. access day 1 inactive lever presses0.62.36.0-1.62.4-1.0-2.3-2.22.4-2.52.32.31.70.30.20.40.30.2-0.21.00.80.91.00.71.0
Intermitt. access day 15 inactive lever presses0.81.74.2-1.11.90.7-1.9-2.01.8-1.81.91.81.90.10.60.70.60.00.51.11.01.11.30.61.1
Intermitt. access escalation Index0.40.61.7-0.81.3-0.4-1.2-1.01.0-1.01.01.01.20.10.30.50.20.2-0.30.50.60.70.20.20.3
Intermittent access day 1 total infusions0.00.10.1-0.30.20.4-0.3-0.40.3-0.30.30.20.3-0.00.00.10.0-0.10.00.10.10.10.30.10.1
Intermittent access day 15 total infusions0.10.20.9-0.90.50.2-0.5-0.40.6-0.60.60.60.5-0.5-0.4-0.4-0.4-0.4-0.5-0.3-0.3-0.2-0.1-0.2-0.1
Intermittent access terminal intake (last 3 days)0.30.41.1-1.10.60.3-0.6-0.60.7-0.70.60.60.5-0.8-0.7-0.7-0.6-0.8-0.7-0.5-0.5-0.4-0.3-0.5-0.3
Intermittent access total infusions0.10.10.7-0.80.40.6-0.4-0.50.5-0.50.50.40.4-0.2-0.2-0.1-0.1-0.1-0.3-0.1-0.0-0.00.1-0.00.0
Intermittent access day 1 locomotion0.10.10.3-0.20.3-0.5-0.4-0.50.2-0.20.20.10.3-0.4-0.10.1-0.1-0.5-0.10.10.10.10.1-0.2-0.0
Intermittent access day 15 total locomotion0.20.31.2-1.10.5-0.4-0.5-0.60.5-0.50.30.20.0-1.0-0.7-0.6-0.7-1.0-0.6-0.4-0.5-0.4-0.1-0.6-0.3
Intermittent access total locomotion0.10.10.4-0.60.4-0.2-0.5-0.60.4-0.40.40.30.3-0.7-0.3-0.3-0.3-0.7-0.3-0.1-0.2-0.10.1-0.3-0.1
Intermittent access standard deviation0.30.62.40.3-1.30.21.10.7-0.70.7-0.8-0.8-1.6-0.1-0.7-0.9-0.6-0.2-0.2-0.5-1.0-1.0-0.4-0.3-0.4
Left kidney weight0.31.21.9-0.5-0.4-1.20.51.0-0.60.6-0.9-1.0-0.9-1.4-1.4-1.3-1.4-1.3-1.3-1.1-1.3-1.3-1.3-1.4-1.3
Right kidney weight0.20.91.6-0.4-0.3-1.00.50.9-0.60.7-0.9-1.1-0.7-1.3-1.1-1.0-1.1-1.2-1.0-1.0-1.1-1.1-1.0-1.2-1.2
Cocaine induced anxiety1.41.95.0-2.20.2-1.90.00.10.3-0.30.20.3-0.8-1.4-1.9-2.0-1.8-1.4-2.1-1.2-1.9-1.8-1.6-1.2-1.2
Post-drug Anxiety0.80.93.1-1.0-0.9-1.11.00.6-0.50.4-0.5-0.5-1.8-0.3-1.1-1.4-1.0-0.3-0.8-0.6-1.4-1.4-0.9-0.4-0.6
Baseline Anxiety1.01.12.61.6-1.60.91.40.9-1.41.3-1.3-1.4-1.41.00.80.60.81.11.40.40.30.20.50.60.4
Tail length1.66.214.5-3.83.7-3.2-2.9-1.62.7-2.52.02.12.2-3.1-2.4-1.9-2.5-3.1-3.2-1.8-1.3-1.1-1.4-2.2-1.6
Length with tail1.77.415.8-3.42.3-3.7-1.3-0.21.1-0.90.30.50.2-4.0-3.4-3.1-3.5-3.8-4.0-2.8-2.7-2.5-2.8-3.3-2.8
Length without tail1.13.77.3-1.70.0-2.10.50.7-0.50.6-0.9-1.0-1.5-2.7-2.5-2.5-2.6-2.5-2.2-2.1-2.4-2.4-2.1-2.4-2.2
Times rat made contact with spout1.11.23.2-1.70.2-1.8-0.1-0.20.3-0.3-0.1-0.2-1.0-1.6-1.6-1.5-1.6-1.6-0.7-1.0-1.4-1.3-0.2-1.2-1.0
Lifetime Intake0.00.00.4-0.40.00.6-0.1-0.30.2-0.20.30.10.2-0.10.0-0.00.0-0.00.10.00.00.10.30.10.2
Liver weight, left0.50.92.10.7-1.2-0.61.31.4-1.31.3-1.3-1.3-1.1-0.3-0.6-0.6-0.6-0.3-0.4-0.6-0.8-0.9-1.0-0.7-0.9
Liver weight, right1.42.56.4-2.22.5-1.8-1.9-1.11.5-1.41.11.11.5-2.2-1.5-1.1-1.6-2.2-1.8-1.1-0.8-0.6-0.7-1.7-1.2
Locomotor activity0.30.42.11.4-0.91.10.70.5-0.70.6-0.6-0.5-0.70.60.50.40.50.60.80.60.20.20.50.40.3
Locomotor testing distance0.71.23.31.8-0.81.70.40.1-0.50.4-0.1-0.0-0.21.31.31.21.21.41.61.41.01.01.21.11.0
Locomotor testing rearing0.71.44.00.90.11.6-0.5-1.10.4-0.50.50.40.51.21.31.31.21.21.71.81.31.32.01.31.4
Locomotion in novel chamber0.20.20.80.10.50.0-0.5-0.50.2-0.10.30.10.80.10.50.80.40.00.20.90.60.70.40.20.3
Locomotion in novel chamber post-restriction0.91.44.3-2.11.4-1.8-1.0-0.81.1-1.00.80.61.0-1.4-1.2-1.1-1.2-1.4-1.5-1.5-0.8-0.7-0.9-1.0-0.8
Fecal boli incidents, locomotor time 10.10.21.01.0-0.40.70.30.4-0.50.5-0.2-0.2-0.10.20.40.50.40.20.30.30.30.30.30.20.1
Change in fecal boli incidents, locomotor task1.71.74.81.1-2.10.92.21.7-1.91.8-1.8-1.7-2.20.0-0.5-0.9-0.40.10.3-1.0-1.1-1.2-0.8-0.4-0.7
Time >=10cm from walls, locomotor time 10.60.71.60.20.81.0-0.8-1.20.8-0.80.60.41.20.20.80.80.80.21.10.11.01.01.20.60.8
Bouts of movement, locomotor time 10.70.82.21.4-1.50.41.41.3-1.21.2-1.0-1.0-1.01.10.60.40.61.00.40.20.10.0-0.40.60.2
Total resting periods, locomotor time 11.01.13.41.5-1.80.11.81.7-1.61.5-1.4-1.4-1.30.90.30.10.40.80.3-0.1-0.2-0.3-0.50.3-0.1
Rest time, locomotor task time 10.81.02.10.5-1.1-0.71.31.4-1.31.3-1.0-1.0-1.3-0.4-0.8-0.9-0.8-0.5-0.8-0.8-1.1-1.1-1.3-0.8-1.0
Distance moved, locomotor task time 10.20.31.1-0.61.00.0-1.0-0.90.9-0.80.70.70.8-0.10.10.20.0-0.1-0.10.20.40.40.30.10.2
Vertical activity count, locomotor time 10.61.43.5-0.91.70.0-1.8-1.91.7-1.61.51.41.60.00.50.70.50.10.80.61.01.11.40.50.9
Time >=10cm from walls, locomotor time 20.40.61.50.0-0.40.00.40.6-0.70.8-0.9-1.1-0.3-1.2-0.7-0.6-0.8-1.2-0.5-1.1-0.6-0.6-0.6-1.1-1.1
Bouts of movement, locomotor time 20.30.61.30.8-1.10.30.90.7-0.80.8-0.7-0.8-0.21.20.90.70.91.10.70.50.50.50.10.70.5
Total resting periods, locomotor time 20.20.40.80.6-0.60.20.40.4-0.50.5-0.4-0.50.30.90.90.80.90.90.60.50.70.70.20.60.5
Rest time, locomotor task time 20.20.30.80.1-0.3-0.90.60.5-0.70.7-0.6-0.7-0.3-0.6-0.3-0.3-0.3-0.6-0.3-0.6-0.4-0.4-0.6-0.5-0.6
Distance moved, locomotor task time 20.00.10.10.20.30.4-0.30.20.1-0.10.10.10.2-0.2-0.2-0.0-0.3-0.3-0.40.0-0.1-0.0-0.3-0.3-0.3
Vertical activity count, locomotor time 20.30.40.80.60.70.7-0.8-0.70.6-0.60.70.60.90.40.60.70.50.30.70.60.80.80.90.40.5
Light reinforcement 11.02.45.7-1.22.10.2-2.4-2.22.2-2.22.02.02.30.30.81.20.80.10.51.11.41.61.80.91.2
Light reinforcement 21.01.54.2-2.02.1-1.2-2.0-1.51.7-1.71.41.41.9-0.9-0.4-0.0-0.5-1.0-1.0-0.20.20.40.1-0.5-0.1
Bone: marrow area0.40.91.40.60.61.0-0.7-0.70.6-0.71.01.11.01.01.11.11.11.00.71.01.21.20.51.01.0
Bone: maximum diameter1.12.04.9-1.91.4-1.9-0.9-0.10.7-0.60.20.30.5-1.9-1.7-1.4-1.7-1.9-2.2-1.6-1.2-1.1-1.7-1.7-1.5
Bone: maximum force2.13.711.2-3.33.0-2.3-2.5-1.82.5-2.42.12.11.6-1.8-1.6-1.3-1.6-1.8-2.1-1.2-0.8-0.6-0.6-1.2-0.8
Bone: maximum moment2.44.213.5-3.73.1-2.5-2.5-1.82.6-2.52.12.21.4-2.0-1.9-1.6-1.8-2.0-2.2-1.4-1.0-0.8-0.7-1.3-0.9
Mean time between licks in bursts0.30.72.41.5-1.30.01.11.1-1.21.1-0.9-1.0-0.60.90.70.70.70.90.10.60.40.3-0.40.50.2
Mean num. licks in bursts0.10.20.8-0.8-0.2-0.40.1-0.10.3-0.40.20.3-0.9-0.2-0.6-0.7-0.5-0.30.4-0.0-0.6-0.60.7-0.10.0
Cd content in liver2.32.64.61.20.12.0-0.7-1.20.7-0.81.21.20.91.91.91.92.01.91.72.11.91.92.02.12.0
Co content in liver0.10.10.3-0.30.1-0.3-0.1-0.10.1-0.1-0.0-0.1-0.2-0.2-0.3-0.3-0.3-0.2-0.6-0.1-0.3-0.2-0.3-0.2-0.2
Cu content in liver0.91.02.2-1.50.3-1.1-0.0-0.10.2-0.2-0.1-0.2-0.7-1.4-1.4-1.5-1.4-1.4-1.1-1.2-1.3-1.3-0.7-1.1-1.0
Fe content in liver0.50.61.50.9-0.10.7-0.2-0.20.2-0.20.40.50.31.01.01.01.01.00.91.20.90.91.01.11.0
K content in liver1.11.13.7-0.91.7-0.4-1.8-1.41.5-1.41.31.31.9-0.40.20.50.1-0.4-0.00.40.70.80.80.00.3
Mg content in liver1.41.54.70.31.40.7-1.6-1.51.2-1.11.31.22.20.41.21.51.10.40.71.11.61.61.30.71.0
Mn content in liver0.10.10.5-0.20.3-0.3-0.2-0.1-0.00.1-0.2-0.30.1-0.7-0.4-0.3-0.4-0.70.0-0.4-0.2-0.20.2-0.6-0.4
Na content in liver0.20.20.90.00.60.0-0.5-0.30.3-0.30.30.41.00.10.40.60.30.10.10.30.50.60.50.20.2
Rb content in liver1.82.05.0-0.71.90.6-2.1-2.22.1-2.12.12.01.90.20.70.90.70.20.41.01.21.31.30.91.2
Se content in liver0.50.61.4-0.60.90.4-0.9-1.21.0-1.01.01.00.90.20.40.40.40.20.60.50.60.61.10.60.8
Sr content in liver0.90.82.1-0.3-1.0-0.51.11.0-0.90.9-1.0-1.0-1.5-0.4-0.8-1.0-0.8-0.4-0.4-0.8-1.1-1.1-0.7-0.6-0.8
Zn content in liver0.70.81.6-1.31.2-1.0-1.0-0.80.8-0.70.50.41.1-1.2-0.7-0.5-0.8-1.2-1.2-0.7-0.3-0.2-0.6-0.9-0.6
Bone: minimum diameter1.52.79.2-3.02.1-1.8-1.8-1.21.9-1.81.41.50.5-1.8-1.8-1.6-1.7-1.8-2.1-1.3-1.2-1.0-0.9-1.3-0.9
Time in familiar zone, hab. session 10.10.10.5-0.2-0.40.40.30.1-0.0-0.0-0.0-0.0-0.70.30.1-0.10.10.30.60.2-0.1-0.10.60.40.3
Time in novel zone, hab. session 10.10.10.60.20.30.0-0.3-0.20.2-0.10.20.10.8-0.10.10.20.1-0.1-0.10.10.20.30.1-0.00.0
Total zone transitions, hab. session 10.70.91.90.8-0.21.1-0.2-0.30.3-0.30.50.60.31.41.21.11.21.41.21.31.11.11.11.31.2
Total locomotion distance, hab. session 11.31.82.80.00.81.0-1.3-1.51.5-1.51.61.61.11.31.21.21.21.31.01.71.41.41.61.61.6
Locomotion velocity, hab. session 11.21.62.7-0.00.90.8-1.3-1.51.4-1.51.71.71.21.31.11.21.11.20.71.61.31.41.31.51.5
Time in familiar zone, hab. session 20.80.81.90.6-0.21.1-0.1-0.60.3-0.40.60.70.21.41.11.01.11.41.01.20.90.91.01.31.2
Time in novel zone, hab. session 20.20.20.60.2-0.2-0.30.40.6-0.60.6-0.7-0.8-0.1-0.6-0.4-0.3-0.4-0.7-0.1-0.6-0.4-0.4-0.3-0.7-0.6
Total zone transitions, hab. session 22.02.64.21.10.61.7-1.0-1.10.9-1.01.21.31.61.82.02.11.91.81.72.02.12.11.91.81.8
Total locomotion distance, hab. session 22.12.75.10.21.61.1-1.9-1.81.7-1.72.01.92.31.11.51.81.51.21.11.71.92.01.81.51.6
Locomotion velocity, hab. session 21.92.55.3-0.11.80.8-2.1-1.91.9-1.92.12.02.30.91.31.61.30.90.71.51.81.81.51.21.5
Novel to familiar place preference ratio1.01.15.2-2.31.0-0.7-0.8-1.11.2-1.20.90.8-0.5-1.3-1.2-1.4-1.1-1.2-0.3-0.8-0.9-0.90.5-0.6-0.2
Novelty place preference1.01.14.9-2.20.9-0.8-0.7-0.91.1-1.10.70.6-0.5-1.3-1.3-1.4-1.2-1.3-0.4-0.9-1.0-1.00.3-0.7-0.4
Time in novel zone, NPP test0.80.83.9-2.00.9-0.5-0.8-1.01.1-1.10.80.7-0.4-1.1-1.0-1.1-0.9-1.0-0.1-0.7-0.8-0.70.6-0.5-0.1
Total zone transitions, NPP test2.13.05.61.50.61.8-1.1-1.00.8-0.81.21.31.91.92.22.42.11.91.62.12.32.31.81.91.9
Total locomotion distance, NPP test2.94.06.60.81.51.7-1.9-2.01.7-1.82.12.12.61.72.22.42.11.91.22.32.52.61.92.02.2
Locomotion velocity, NPP test2.23.15.10.41.51.3-1.9-1.91.7-1.82.02.02.31.51.82.01.81.60.81.92.12.21.61.81.9
Intraocular pressure0.50.71.9-0.71.00.5-1.1-1.21.3-1.31.41.20.70.30.40.30.40.40.40.40.60.60.80.60.8
Delta distance traveled before/after self-admin1.01.12.10.70.21.2-0.4-0.80.5-0.50.60.60.61.21.21.31.21.21.41.41.21.21.41.31.3
Delta ambulatory time before/after self-admin1.11.33.01.3-0.41.60.1-0.3-0.20.10.0-0.10.21.41.51.51.41.41.71.41.41.31.41.31.2
Parametrial fat weight0.30.72.7-1.31.6-0.7-1.3-1.01.2-1.21.11.11.1-0.5-0.10.1-0.1-0.5-0.40.00.30.40.2-0.10.1
Pavlov. Cond. lever latency4.45.59.41.70.03.0-0.8-1.61.0-1.11.71.61.12.92.82.72.93.02.92.92.72.62.83.13.0
Pavlov. Cond. magazine entry latency2.02.66.2-2.40.7-2.5-0.30.10.4-0.3-0.2-0.0-0.5-1.8-2.1-2.0-2.1-1.9-2.4-1.7-1.9-1.8-1.9-1.7-1.6
Pavlov. Cond. change in total contacts1.01.02.2-1.2-0.4-1.00.60.5-0.30.3-0.7-0.6-1.4-0.9-1.3-1.5-1.3-1.0-0.9-1.1-1.4-1.4-0.9-0.9-0.9
Pavlov. Cond. index score3.13.98.5-2.61.2-2.9-0.50.10.5-0.3-0.3-0.1-0.1-2.5-2.5-2.3-2.6-2.6-2.9-2.2-2.1-2.0-2.2-2.4-2.2
Pavlov. Cond. latency score3.74.79.6-2.40.8-3.1-0.10.7-0.00.2-0.8-0.6-0.4-2.7-2.8-2.5-2.8-2.9-3.1-2.6-2.4-2.3-2.6-2.7-2.6
Pavlov. Cond. lever contacts2.12.65.0-1.40.3-2.20.20.8-0.40.5-0.9-0.8-0.4-2.0-2.0-1.8-2.0-2.2-2.2-1.9-1.8-1.7-1.9-2.1-2.0
Pavlov. Cond. magazine entry number2.93.77.52.6-0.32.7-0.2-0.5-0.10.00.60.41.22.12.62.62.52.22.52.22.42.32.32.12.0
Pavlov. Cond. intertrial magazine entries1.01.12.0-0.01.10.9-1.2-1.41.1-1.11.31.31.30.61.01.01.00.70.90.91.21.21.31.01.1
Pavlov. Cond. lever-magazine prob. diff.2.63.37.2-2.61.2-2.7-0.6-0.10.6-0.5-0.10.1-0.1-2.3-2.3-2.1-2.3-2.4-2.6-2.0-1.9-1.8-1.9-2.1-1.9
Pavlov. Cond. response bias2.93.57.1-2.30.3-2.70.20.6-0.10.2-0.8-0.7-0.9-2.2-2.5-2.4-2.4-2.3-2.5-2.2-2.3-2.2-2.3-2.2-2.1
Pavlov. Cond. lever latency2.23.05.80.5-1.8-1.22.12.4-2.22.2-2.4-2.4-1.8-1.0-1.3-1.4-1.3-1.1-0.8-1.8-1.7-1.8-1.6-1.6-1.8
Pavlov. Cond. magazine entry latency2.93.57.82.0-0.52.8-0.2-0.80.3-0.40.80.80.42.42.32.22.32.42.42.42.12.02.12.42.3
Pavlov. Cond. change in total contacts2.13.45.70.90.52.2-1.0-1.61.2-1.41.71.70.92.22.01.92.12.21.82.32.02.02.02.42.4
Pavlov. Cond. index score2.53.35.60.80.52.2-1.1-1.71.4-1.51.81.80.82.11.91.82.02.11.82.41.91.92.12.32.4
Pavlov. Cond. latency score2.43.25.50.80.62.1-1.2-1.71.4-1.51.81.81.02.01.91.92.02.01.72.32.02.02.02.22.3
Pavlov. Cond. lever contacts2.33.15.6-0.21.71.4-2.0-2.42.1-2.22.32.41.71.21.41.51.51.31.01.91.81.81.71.72.0
Pavlov. Cond. magazine entry number2.73.36.9-1.60.3-2.60.41.1-0.60.7-1.0-1.0-0.5-2.3-2.2-2.0-2.2-2.3-2.3-2.4-2.0-2.0-2.2-2.3-2.3
Pavlov. Cond. intertrial magazine entries0.50.82.5-1.51.6-1.0-1.4-1.11.2-1.21.01.01.1-0.8-0.5-0.3-0.5-0.9-0.5-0.3-0.10.00.3-0.5-0.2
Pavlov. Cond. lever-magazine prob. diff.2.53.35.81.00.32.3-0.9-1.51.2-1.31.61.60.62.22.01.92.02.31.92.41.91.92.12.42.4
Pavlov. Cond. response bias2.33.14.90.50.82.1-1.3-1.91.5-1.61.91.91.11.81.81.71.81.91.62.21.91.92.02.12.2
Time in closed arm before self-admin0.70.92.10.1-1.4-1.11.41.3-1.21.2-1.1-1.0-1.40.1-0.5-0.7-0.40.1-0.3-1.0-0.9-1.0-0.9-0.3-0.7
Time in closed arm after self-admin1.92.04.01.0-1.9-1.42.02.0-2.02.0-2.0-1.9-1.6-0.9-0.7-0.9-0.7-0.9-0.2-1.5-1.1-1.2-1.1-1.0-1.2
Time in open arm before self-admin0.30.31.20.30.9-0.0-0.8-0.40.2-0.10.20.11.0-1.10.00.3-0.1-1.1-0.20.10.30.40.1-0.7-0.3
Time in open arm after self-admin0.60.71.20.10.71.1-0.9-0.90.8-0.80.90.70.90.80.70.90.70.80.41.10.90.90.70.80.8
Bone: periosteal estimation0.61.43.8-1.91.9-1.2-1.5-1.01.5-1.41.31.41.1-1.1-0.9-0.8-0.9-1.1-1.4-0.7-0.4-0.3-0.7-0.7-0.5
Bone: periosteal perimeter3.56.111.9-3.01.4-3.4-0.50.60.4-0.2-0.3-0.2-0.5-3.1-3.2-3.0-3.2-3.2-3.4-3.0-2.7-2.6-2.9-3.0-2.8
Bone: post-yield work0.10.10.30.50.10.4-0.3-0.10.1-0.10.20.20.40.30.50.50.40.40.10.40.50.50.20.30.3
Progressive ratio test 1 active lever presses0.20.20.7-0.50.60.3-0.6-0.80.8-0.80.80.70.60.00.10.00.20.00.30.10.20.30.60.30.4
Progressive ratio test 1 breakpoint0.20.20.7-0.60.60.2-0.6-0.80.8-0.80.80.70.6-0.10.0-0.00.1-0.10.2-0.00.20.20.50.20.3
Progressive ratio test 1 inactive lever presses1.92.76.9-1.42.6-0.4-2.6-2.62.6-2.62.52.42.3-0.20.20.50.2-0.3-0.20.80.91.01.20.51.0
Progressive ratio test 2 active lever presses0.10.10.4-0.30.30.3-0.4-0.60.5-0.50.40.30.2-0.10.10.00.1-0.00.30.10.20.20.50.20.3
Progressive ratio test 2 breakpoint0.10.10.4-0.30.30.4-0.4-0.60.5-0.50.50.40.2-0.00.10.00.1-0.00.30.10.20.20.50.20.3
Progressive ratio test 2 inactive lever presses0.10.20.4-0.60.50.2-0.4-0.50.5-0.50.50.40.1-0.6-0.5-0.4-0.5-0.6-0.5-0.0-0.4-0.3-0.0-0.3-0.1
Incentive Sensitization - Responses0.00.00.10.10.3-0.2-0.3-0.20.3-0.30.30.20.2-0.1-0.0-0.00.0-0.00.1-0.00.10.10.20.00.1
Incentive Sensitization - Breakpoint0.00.00.10.10.3-0.1-0.2-0.20.3-0.30.20.20.1-0.1-0.0-0.0-0.0-0.00.10.00.00.10.20.10.1
Sum of active levers in priming session hrs 5-60.90.92.0-0.2-0.10.6-0.5-0.81.3-1.41.31.3-0.81.40.2-0.20.41.40.70.90.10.11.11.41.3
Progressive ratio0.30.41.81.1-0.91.30.80.5-0.80.8-0.7-0.7-0.50.60.50.40.50.70.70.50.20.10.20.40.3
Food seeking constrained by brief footshock0.20.31.4-0.5-0.80.50.80.4-0.50.5-0.5-0.5-1.2-0.1-0.4-0.6-0.3-0.10.2-0.2-0.6-0.6-0.0-0.0-0.1
Seeking ratio, punishment vs. effort0.10.10.5-0.70.4-0.3-0.5-0.40.5-0.50.60.70.30.20.20.20.20.20.10.10.30.30.30.30.3
Retroperitoneal fat weight1.98.322.1-4.14.7-0.7-4.5-4.54.7-4.64.34.23.3-0.6-0.00.30.0-0.6-0.61.01.11.41.60.71.5
Reaction time number correct4.79.013.91.12.22.8-2.8-3.32.6-2.73.02.83.62.73.23.53.22.52.43.43.73.73.23.13.4
Reaction time mean minus median0.41.01.4-0.1-0.8-1.01.01.1-1.01.1-1.1-1.0-0.9-1.0-0.9-0.9-0.9-1.1-0.7-1.2-1.1-1.1-1.1-1.1-1.2
Reaction time mean minus median AUC0.40.92.2-0.3-0.1-1.40.30.7-0.70.7-0.8-0.9-0.1-1.4-0.9-0.7-1.0-1.5-1.2-1.0-0.8-0.8-1.3-1.3-1.3
Reaction time num false alarms0.20.20.90.6-1.00.20.50.7-0.40.3-0.1-0.1-0.70.80.30.20.40.80.10.20.10.1-0.30.40.2
Reaction time num false alarms AUC0.20.41.21.0-1.10.50.70.9-0.60.6-0.3-0.4-0.60.90.50.40.50.90.30.30.30.2-0.20.50.3
Reaction time trials correct on left4.79.013.91.12.22.8-2.8-3.32.6-2.73.02.83.62.73.23.53.22.52.43.43.73.73.23.13.4
Reaction time trials on left4.99.214.21.12.22.8-2.8-3.42.6-2.73.02.93.72.73.23.53.22.52.43.43.73.83.23.13.4
Reaction time mean0.20.30.7-0.70.70.1-0.7-0.80.7-0.70.80.80.6-0.00.20.20.2-0.00.10.10.40.40.20.20.4
Reaction time mean AUC0.30.51.0-0.50.90.2-1.0-0.90.9-0.91.01.01.00.20.50.60.50.20.20.50.70.80.40.40.6
Median of all reaction times0.50.71.6-0.71.00.4-1.1-1.21.1-1.11.31.21.00.40.60.60.60.30.30.50.80.80.50.60.8
Reaction time omissions0.20.20.8-0.20.9-0.2-0.9-0.50.7-0.70.80.80.8-0.2-0.00.2-0.1-0.2-0.40.20.20.3-0.2-0.20.0
Reaction time false alarm rate1.72.35.90.4-2.1-0.92.02.4-1.81.8-1.8-1.7-2.3-0.5-1.1-1.3-1.0-0.4-0.8-1.4-1.6-1.6-1.7-1.1-1.4
Reaction time premature initiation rate0.70.92.41.3-1.50.81.20.6-1.01.0-0.6-0.4-1.41.40.80.60.91.41.20.80.40.30.40.90.6
Reaction time premature initiations2.23.97.31.7-0.22.3-0.4-1.30.5-0.61.11.20.72.72.52.42.52.62.52.52.32.32.22.52.4
Std. dev. reaction times0.10.10.40.6-0.60.40.40.4-0.50.5-0.2-0.2-0.20.30.40.40.40.30.40.10.30.2-0.10.20.2
Reaction time trials completed4.99.214.21.12.22.8-2.8-3.42.6-2.73.02.93.72.73.23.53.22.52.43.43.73.83.23.13.4
Reaction time trials AUC4.99.314.31.02.32.8-2.9-3.42.7-2.73.12.93.72.73.23.53.22.52.53.43.73.83.33.13.4
Run reversals in cocaine runway, females1.81.85.11.2-0.71.80.1-0.20.1-0.20.30.40.22.31.71.61.82.31.61.41.51.41.21.91.6
Run reversals in cocaine runway, males1.31.32.8-1.30.5-0.9-0.10.10.2-0.20.1-0.1-0.3-1.7-1.5-1.6-1.5-1.6-1.4-1.5-1.4-1.3-1.1-1.3-1.2
Latency to leave start box in cocaine runway0.30.30.70.4-0.50.80.40.3-0.40.3-0.4-0.5-0.00.90.70.70.70.90.70.50.50.50.40.60.5
Latency to leave start box in cocaine runway, F0.91.02.20.80.21.1-0.6-0.40.3-0.30.40.40.91.21.31.51.21.21.01.41.41.41.01.01.1
Latency to leave start box in cocaine runway, M0.30.30.7-0.3-0.80.00.90.6-0.60.6-0.7-0.8-0.8-0.0-0.3-0.5-0.2-0.00.1-0.6-0.5-0.6-0.2-0.1-0.3
Std. dev. time between licks in bursts2.53.46.90.31.9-0.2-2.2-1.91.9-1.92.12.12.61.41.92.21.91.30.52.02.42.41.61.81.9
Total sessions with >9 infusions0.10.10.90.4-0.40.90.4-0.0-0.40.4-0.2-0.40.2-0.00.30.20.3-0.10.80.10.20.20.60.20.3
Short access day 1 total inactive lever presses0.10.10.4-0.00.6-0.6-0.6-0.20.3-0.20.40.50.5-0.20.10.40.0-0.1-0.40.50.30.4-0.1-0.2-0.1
Short access day 10 total inactive lever presses0.71.85.3-1.92.3-1.5-2.1-1.92.1-2.01.81.81.5-0.7-0.5-0.2-0.5-0.7-1.00.20.10.30.2-0.20.2
Short access day 1 total infusions0.60.82.11.1-1.21.21.00.5-0.90.9-0.7-0.9-0.41.00.90.70.90.91.40.60.60.50.80.70.6
Short access day 10 total infusions0.40.51.5-1.20.7-0.9-0.7-0.90.9-0.90.80.70.4-0.8-0.7-0.7-0.7-0.8-0.8-0.4-0.5-0.4-0.1-0.4-0.2
Short access total infusions0.10.20.7-0.2-0.10.6-0.1-0.50.3-0.30.40.20.20.40.40.30.40.40.70.40.30.30.90.50.6
Short access day 1 locomotion0.20.20.80.1-0.80.20.90.4-0.70.7-0.7-0.9-0.6-0.1-0.2-0.3-0.2-0.20.1-0.5-0.4-0.5-0.3-0.2-0.3
Short access day 10 total locomotion0.61.21.9-0.0-0.8-0.91.00.8-0.90.9-1.0-1.1-1.1-1.2-1.2-1.3-1.1-1.3-0.8-1.2-1.3-1.4-1.0-1.2-1.1
Short access total locomotion0.60.71.5-0.4-0.5-0.50.70.5-0.70.7-0.7-0.9-0.7-1.1-0.9-1.1-0.9-1.2-0.6-1.1-1.0-1.1-0.7-1.0-0.9
One hour access (0.3 mA shock)0.30.41.2-0.40.30.8-0.6-0.90.7-0.80.70.60.60.30.50.40.50.40.90.30.60.61.10.60.8
Compulsive drug intake0.91.02.5-0.31.6-0.5-1.4-1.01.3-1.31.41.51.60.50.70.80.70.60.30.71.01.10.70.70.8
One hour access (shock baseline)0.10.10.4-0.4-0.20.3-0.0-0.1-0.10.2-0.2-0.30.0-0.6-0.2-0.2-0.3-0.6-0.3-0.3-0.2-0.2-0.2-0.4-0.3
Social response proportion0.40.51.10.80.11.1-0.2-0.60.1-0.20.30.30.30.70.90.90.80.60.61.00.80.80.70.80.8
Social responses0.10.20.40.30.40.6-0.3-0.60.2-0.20.20.00.50.30.40.50.40.20.20.50.50.50.40.30.4
Social time0.20.31.50.40.11.2-0.2-0.50.2-0.20.20.10.20.60.60.60.60.50.70.60.60.60.70.60.7
Soleus weight0.72.14.6-2.21.9-2.1-1.5-0.71.2-1.10.80.91.4-1.7-1.4-1.1-1.5-1.7-2.1-1.2-0.8-0.7-1.3-1.5-1.2
Bone: stiffness0.20.41.3-0.81.1-0.7-0.9-0.40.7-0.70.70.80.7-0.5-0.3-0.2-0.4-0.5-0.9-0.5-0.1-0.0-0.5-0.4-0.3
Tibialis anterior weight0.00.10.70.10.50.4-0.3-0.10.1-0.10.30.30.80.10.40.40.40.20.2-0.00.50.5-0.10.10.2
Time to tail flick, vehicle, before self-admin0.40.40.90.5-0.7-0.80.60.9-0.80.9-0.7-0.9-0.4-0.3-0.3-0.2-0.3-0.4-0.5-0.4-0.4-0.4-0.8-0.6-0.7
Time to tail flick, vehicle, after self-admin0.81.03.21.4-1.4-0.61.31.6-1.81.8-1.6-1.5-0.8-0.20.00.1-0.1-0.2-0.2-0.2-0.3-0.3-0.9-0.7-0.8
Time to tail flick, test, before self-admin0.40.41.30.1-0.9-0.30.91.1-0.90.9-0.8-0.8-0.7-0.3-0.3-0.4-0.3-0.3-0.2-0.6-0.6-0.6-0.6-0.5-0.6
Time to tail flick, test, after self-admin1.01.02.20.8-1.3-0.11.41.2-1.41.5-1.4-1.5-1.4-0.8-0.6-0.7-0.7-0.8-0.2-0.6-0.9-1.0-0.7-0.9-0.9
Delta time to tail flick, vehicle, before/after SA0.20.20.50.00.70.3-0.6-0.70.4-0.40.30.50.70.10.40.60.30.10.20.70.60.60.50.20.4
Delta time to tail flick, test, before/after SA0.30.41.10.5-0.80.70.90.5-0.80.8-0.8-0.9-1.1-0.3-0.3-0.5-0.3-0.30.2-0.4-0.5-0.6-0.2-0.3-0.3
Tibia length5.114.137.3-6.13.8-5.4-2.6-1.12.6-2.31.31.30.9-4.9-4.6-4.2-4.6-4.7-4.9-4.0-3.4-3.1-3.0-4.1-3.4
Ambulatory time before self-admin0.91.34.0-2.01.6-0.7-1.6-1.61.9-1.91.51.60.9-0.5-0.8-0.8-0.7-0.6-1.0-0.2-0.4-0.30.0-0.10.1
Ambulatory time after self-admin1.21.43.0-0.61.20.8-1.4-1.71.7-1.71.51.61.10.70.60.70.70.70.81.10.91.01.51.11.3
Bone: tissue strength1.01.02.9-1.41.7-0.5-1.7-1.61.6-1.61.41.41.3-0.6-0.2-0.0-0.2-0.6-0.40.10.30.40.6-0.10.2
Total heroin consumption0.10.20.7-0.4-0.00.2-0.2-0.10.5-0.60.50.5-0.8-0.2-0.4-0.5-0.4-0.2-0.00.3-0.4-0.40.40.10.2
Bone: trabecular number0.10.20.6-0.10.1-0.40.30.6-0.40.4-0.5-0.4-0.0-0.5-0.4-0.4-0.4-0.4-0.1-0.8-0.4-0.4-0.6-0.6-0.6
Bone: trabecular spacing4.25.68.20.61.52.2-2.3-2.92.3-2.42.72.72.51.92.32.42.31.91.82.82.72.72.82.52.7
Bone: trabecular thickness2.02.54.5-1.6-0.3-1.90.81.3-0.60.7-1.0-0.9-1.5-1.7-2.0-2.1-1.9-1.7-1.7-2.0-2.0-2.0-1.8-1.8-1.8
Bone: trabecular tissue density0.30.41.71.3-1.00.20.80.8-1.01.0-0.7-0.7-0.50.70.50.50.40.50.30.40.20.2-0.10.2-0.0
Water consumed over 24 hours0.81.01.6-0.3-0.8-0.70.91.0-0.80.9-1.1-1.2-1.3-1.2-1.2-1.2-1.2-1.1-0.3-1.0-1.2-1.3-0.3-1.1-1.1
Number of responses in last shaping day0.10.20.8-0.20.5-0.7-0.2-0.3-0.00.10.1-0.00.3-0.7-0.3-0.2-0.4-0.9-0.6-0.1-0.2-0.2-0.4-0.6-0.4