Hub : Genes

Tent4b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Tent4b 0.04 0.03 3.0e-03 0.01 0.03 0.03 0.03 5.1e-02 1.3e-03 2.4e-03 2.1e-03
2 PL gene expression Tent4b 0.04 0.03 1.5e-04 0.03 0.03 0.02 0.03 2.5e-04 3.1e-04 4.9e-03 8.1e-04
3 PL alternative TSS NM_001107416.2 0.12 0.09 2.6e-03 0.02 0.02 0.04 0.03 1.5e-03 2.7e-03 7.3e-05 1.8e-04
4 Adipose alternative TSS XM_063278017.1 0.05 0.04 8.2e-04 0.03 0.01 0.02 0.02 4.9e-04 1.0e-02 2.1e-03 3.6e-03
5 Adipose isoform ratio XM_063278017.1 0.06 0.04 9.6e-04 0.03 0.02 0.02 0.02 4.4e-04 5.1e-03 1.6e-03 2.0e-03
6 Adipose alternative TSS XM_063278017.1 0.06 0.05 1.5e-03 0.02 0.01 0.02 0.02 1.6e-03 1.3e-02 4.1e-03 6.1e-03
7 Brain mRNA stability Tent4b 0.06 0.04 8.5e-04 0.03 0.03 0.01 0.03 6.1e-04 1.1e-03 1.4e-02 5.3e-04
8 PL isoform ratio XM_063278017.1 0.06 0.04 9.2e-03 0 0.01 0.02 0.01 8.1e-02 5.8e-02 3.8e-03 2.8e-02
9 PL alternative TSS XM_063278017.1 0.06 0.05 7.4e-03 0 0 0.01 0.01 8.4e-02 7.9e-02 1.1e-02 4.6e-02
10 PL mRNA stability Tent4b 0.05 0.04 3.7e-03 -0 -0 -0 -0 6.3e-01 7.0e-01 8.1e-01 8.2e-01
11 BLA mRNA stability Tent4b 0.14 0.09 1.8e-03 0.01 0.02 -0 0 8.4e-02 4.1e-02 4.9e-01 3.3e-01
12 LHb alternative TSS XM_039097723.2 0.16 0.11 5.9e-03 0.01 0.06 0.06 0 1.4e-01 1.9e-02 1.8e-02 2.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.91.63.81.91.81.6-1.3-1.3-1.20.7-1.0-1.00.91.00.2
Area under the delay curve0.20.20.5-0.6-0.70.20.50.50.5-0.5-0.1-0.2-0.7-0.3-0.4
BMI with tail1.65.511.8-2.2-2.9-2.43.43.43.00.42.42.20.3-0.4-1.8
BMI without tail0.10.41.0-0.3-0.6-0.50.80.80.80.50.50.51.00.20.3
Body weight0.62.78.7-0.8-1.2-2.91.71.71.51.22.42.31.00.3-0.1
Weight adjusted by age2.23.47.0-1.3-2.1-1.72.62.62.30.41.91.80.0-0.0-2.2
Bone surface0.61.13.31.81.60.0-0.8-0.8-0.71.50.20.31.51.10.1
Bone volume1.32.37.02.62.30.2-1.4-1.4-1.31.8-0.00.11.81.70.8
Breakpoint value in progressive ratio session1.11.32.4-0.20.71.4-1.3-1.3-1.3-1.1-1.5-1.5-1.1-1.00.4
Number of licking bursts0.40.61.20.10.60.7-1.0-1.0-0.9-0.6-0.9-0.9-0.4-0.31.1
Context. condit. distance diff. score3.23.910.3-3.2-2.30.51.01.00.8-2.5-0.7-0.8-2.6-3.0-2.3
Locomotion velocity, session 10.60.62.40.91.0-0.2-0.8-0.8-0.90.4-0.1-0.10.40.71.5
Locomotion distance, session 10.60.81.6-0.7-0.10.9-0.7-0.7-0.7-1.3-1.1-1.1-1.0-1.00.5
Locomotion velocity, session 20.10.20.3-0.20.10.4-0.5-0.5-0.6-0.2-0.5-0.5-0.3-0.50.2
Locomotion distance, session 20.40.61.5-1.1-0.60.5-0.1-0.1-0.2-1.2-0.6-0.6-1.2-1.1-0.5
Locomotion velocity, session 31.51.73.0-1.1-1.6-1.41.71.71.60.11.41.3-0.4-0.2-1.5
Locomotion distance, session 30.20.20.6-0.6-0.7-0.40.40.40.4-0.60.20.2-0.8-0.3-0.2
Stereotopy head waving bouts, day 30.60.71.9-0.9-0.7-0.91.11.10.9-0.10.80.7-0.5-0.6-1.4
Stereotopy head waving duration, day 30.70.81.9-1.1-0.9-0.61.21.21.0-0.30.50.5-0.6-0.7-1.4
Locomotion velocity, session 72.22.45.2-1.8-1.11.80.10.10.1-2.3-1.6-1.7-2.1-2.0-1.5
Locomotion distance, session 72.32.97.2-0.70.42.7-1.1-1.1-1.0-2.2-2.4-2.4-2.0-1.6-0.7
Stereotopy head waving bouts, day 71.61.85.5-0.5-0.8-2.31.51.51.40.81.91.90.50.4-0.4
Stereotopy head waving duration, day 71.31.65.60.70.4-2.40.60.60.51.51.81.91.11.20.7
Locomotion velocity, session 82.53.07.1-2.0-0.91.6-0.1-0.1-0.3-2.6-1.6-1.7-2.7-2.4-1.8
Locomotion distance, session 82.73.99.7-2.9-1.61.20.10.1-0.1-3.0-1.5-1.6-3.0-3.1-1.6
Degree of sensitization distance1.51.54.8-0.30.62.2-0.8-0.8-0.8-1.2-1.8-1.9-1.0-1.1-0.9
Degree of sensitization stereotypy1.21.33.2-0.3-0.8-1.81.31.31.30.81.61.60.70.6-0.0
Conditioned locomotion0.10.10.30.30.30.3-0.3-0.3-0.10.3-0.2-0.10.40.30.5
Cocaine response after cond. corrected1.61.94.1-1.9-1.31.60.50.50.5-2.0-1.3-1.4-1.7-1.6-0.7
Cocaine response after cond. not corrected0.60.71.9-1.4-0.90.70.60.60.6-1.2-0.5-0.6-1.1-0.9-0.3
Cocaine response before conditioning2.12.55.01.91.6-2.1-0.7-0.7-0.72.21.61.71.61.71.5
Saline control response3.64.88.9-0.01.42.9-2.7-2.7-2.4-1.9-3.0-2.9-1.6-1.70.6
Bone: connectivity density0.91.44.41.31.52.1-1.2-1.2-1.10.1-1.4-1.40.30.2-0.5
Bone: cortical apparent density0.60.91.9-0.8-0.61.40.20.20.2-1.2-1.0-1.1-1.1-0.8-1.4
Bone: cortical area0.20.30.80.70.5-0.90.00.0-0.20.80.70.70.80.4-0.2
Bone: cortical porosity0.40.42.0-0.1-0.2-1.40.50.50.40.31.01.00.10.30.1
Bone: cortical porosity0.20.31.40.20.2-1.20.10.10.10.30.70.80.30.30.3
Bone: cortical thickness0.20.40.80.4-0.1-0.80.70.70.50.60.80.80.90.5-0.4
Bone: cortical thickness0.40.51.1-0.6-0.41.1-0.0-0.0-0.1-0.7-0.9-0.9-0.7-0.9-0.9
Bone: cortical tissue density0.81.02.2-0.9-0.71.50.30.30.2-1.3-1.1-1.2-1.2-0.9-1.5
Condit. Reinf. active minus inactive responses0.70.72.4-1.6-1.1-0.20.60.60.5-1.0-0.0-0.1-1.1-1.2-0.6
Condit. Reinf. active-inactive response ratio0.91.03.8-1.9-1.3-0.50.60.60.4-1.00.10.0-1.2-1.6-0.6
Condit. Reinf. active responses0.00.00.10.00.0-0.3-0.0-0.00.0-0.00.10.1-0.00.00.2
Condit. Reinf. inactive responses1.82.27.12.72.20.6-1.4-1.4-1.21.1-0.5-0.31.51.91.3
Incentive salience index mean0.20.30.6-0.10.40.1-0.7-0.7-0.7-0.5-0.5-0.5-0.5-0.40.7
Condit. Reinf. lever presses1.01.53.31.41.50.5-1.7-1.7-1.60.2-0.8-0.70.40.61.8
Condit. Reinf. active minus inactive responses0.20.20.4-0.4-0.4-0.60.60.60.4-0.00.50.5-0.2-0.0-0.5
Condit. Reinf. active-inactive response ratio1.21.32.30.6-0.5-1.31.11.11.11.41.51.51.21.40.1
Condit. Reinf. active responses0.10.20.6-0.4-0.1-0.60.40.40.1-0.30.30.2-0.5-0.3-0.8
Condit. Reinf. inactive responses0.60.82.2-1.2-0.20.20.10.1-0.3-1.3-0.6-0.7-1.4-1.5-1.3
Condit. Reinf. lever presses0.40.61.2-0.9-0.7-0.71.01.00.7-0.40.50.4-0.4-0.6-1.1
Condit. Reinf. lever reinforcers received0.30.41.0-0.5-0.4-1.00.90.90.5-0.10.80.7-0.3-0.2-0.9
Conditioned reinforcement - actives0.10.10.5-0.40.1-0.3-0.2-0.2-0.5-0.4-0.1-0.2-0.3-0.7-0.2
Conditioned reinforcement - inactives0.40.52.0-1.2-0.3-1.40.40.40.1-0.40.70.7-0.2-1.2-0.1
Conditioned locomotion0.10.10.30.00.20.6-0.3-0.3-0.4-0.3-0.4-0.5-0.1-0.3-0.3
Patch foraging indifference point 0 sec0.61.12.9-1.6-1.20.10.40.40.4-1.3-0.3-0.3-1.7-1.5-1.4
Patch foraging indifference point AUC0.50.81.61.11.20.6-1.1-1.1-1.30.0-0.7-0.70.20.50.8
Delay disc. indifference point, 0s delay0.50.61.40.91.2-0.5-1.0-1.0-1.00.4-0.00.00.10.51.2
Delay disc. indifference point, 16s delay0.50.61.5-0.6-1.0-0.31.21.21.0-0.20.40.3-0.1-0.1-0.9
Delay disc. indifference point, 2s delay0.40.41.40.1-0.70.21.01.01.20.20.30.30.60.7-0.3
Delay disc. indifference point, 24s delay0.00.00.1-0.0-0.0-0.0-0.0-0.00.1-0.1-0.1-0.0-0.10.00.3
Delay disc. indifference point, 4s delay1.21.22.9-0.7-0.31.7-0.2-0.2-0.3-1.6-1.6-1.6-1.5-1.0-0.5
Delay disc. indifference point, 8s delay0.50.61.4-1.2-1.1-0.60.80.80.7-0.60.30.3-1.0-0.6-0.4
Indifference point function ln k0.50.82.4-1.3-1.5-0.11.11.11.3-0.30.40.4-0.3-0.6-1.0
Indifference point function log k0.50.82.4-1.3-1.5-0.11.11.11.3-0.30.40.4-0.3-0.6-1.0
Patch foraging total patch changes 0 sec0.71.33.0-1.7-1.3-0.00.60.60.5-1.3-0.2-0.2-1.7-1.6-1.5
Patch foraging total patch changes 12 sec1.31.72.8-0.40.71.1-1.5-1.5-1.6-1.4-1.5-1.5-1.7-1.40.0
Patch foraging total patch changes 18 sec1.01.53.30.41.41.1-1.6-1.6-1.8-0.7-1.4-1.4-1.0-0.8-0.1
Patch foraging total patch changes 24 sec0.81.42.7-0.10.80.8-1.4-1.4-1.6-1.3-1.3-1.3-1.5-1.1-0.1
Patch foraging total patch changes 6 sec0.30.50.9-0.20.20.5-0.9-0.9-0.9-0.8-0.8-0.7-0.8-0.70.1
Patch foraging time to switch 0 sec0.10.21.1-0.40.1-1.0-0.0-0.0-0.10.20.60.6-0.2-0.4-0.1
Patch foraging water rate 0 sec0.10.31.00.60.21.0-0.1-0.10.0-0.2-0.6-0.60.30.70.6
Patch foraging water rate 12 sec0.20.41.21.10.90.5-0.5-0.5-0.50.6-0.3-0.30.90.80.7
Patch foraging water rate 18 sec2.03.17.52.71.8-0.4-1.1-1.1-0.82.00.40.62.42.62.5
Patch foraging water rate 24 sec0.10.10.30.50.20.4-0.1-0.10.10.2-0.1-0.10.50.60.6
Patch foraging water rate 6 sec2.33.46.02.22.52.1-2.3-2.3-2.00.1-1.9-1.70.70.81.5
Seeking ratio, delayed vs. immediate footshock2.22.67.2-2.5-2.7-0.51.81.81.9-1.10.60.5-0.9-1.4-1.8
Distance traveled before self-admin1.62.14.1-1.0-1.7-1.71.81.82.00.71.81.80.50.3-0.4
Distance traveled after self-admin2.02.54.90.9-0.2-2.10.90.91.02.22.12.22.01.80.7
Extensor digitorum longus weight0.72.86.91.40.2-1.90.70.70.82.42.02.12.62.00.7
Bone: elastic displacement0.20.30.9-0.2-0.20.9-0.1-0.1-0.1-0.9-0.7-0.8-0.5-0.3-0.3
Bone: elastic work0.00.00.20.30.10.00.30.30.10.00.10.00.20.4-0.2
Bone: endosteal estimation0.00.10.4-0.3-0.20.1-0.3-0.3-0.4-0.2-0.2-0.2-0.6-0.4-0.0
Bone: endosteal perimeter0.20.51.6-0.9-0.40.3-0.3-0.3-0.5-0.8-0.5-0.5-1.1-1.3-0.7
Epididymis fat weight0.10.51.0-1.0-0.8-1.00.70.70.5-0.40.70.6-0.4-0.5-0.2
Delta time in closed arm before/after self-admin0.20.20.4-0.7-0.60.00.50.50.5-0.40.0-0.0-0.2-0.4-0.2
Delta time in open arm before/after self-admin0.60.61.20.80.91.0-1.1-1.1-0.9-0.0-0.9-0.8-0.10.20.5
Diff in mean of infusions in LGA sessions1.92.44.6-1.2-0.22.1-0.7-0.7-0.8-2.0-1.9-2.0-2.0-2.0-1.1
Delay discount exponential model param0.20.20.50.50.6-0.4-0.5-0.5-0.50.60.30.40.70.30.4
Extinction: sum of active levers before priming2.12.35.1-1.9-2.2-0.12.32.32.1-0.80.50.4-0.6-0.8-1.6
Active lever presses in extinction session 60.20.20.60.3-0.10.40.30.30.60.3-0.00.00.80.60.5
Bone: final force1.62.54.92.21.7-1.9-0.3-0.3-0.62.21.51.51.82.01.1
Bone: final moment1.32.14.21.81.3-2.0-0.0-0.0-0.32.01.61.61.71.70.9
Food consumed during 24 hour testing period2.43.28.12.12.80.9-2.6-2.6-2.80.3-1.3-1.2-0.30.31.1
Glucose0.30.41.80.91.4-0.4-0.7-0.7-0.80.50.10.10.20.40.5
Heart weight0.81.22.4-1.6-1.20.80.70.70.6-1.3-0.6-0.6-1.2-1.5-1.5
Delay discount hyperbolic model param0.20.30.60.60.6-0.5-0.4-0.4-0.40.70.40.40.80.30.4
Intermittent access intake day 1-15 change1.73.57.81.92.60.1-2.7-2.7-2.80.4-0.8-0.71.00.42.6
Intermittent access intake escalation1.42.96.41.72.30.2-2.4-2.4-2.40.4-0.8-0.71.20.42.5
Intermittent access intake escalation 22.12.45.70.92.00.3-2.4-2.4-2.4-0.5-1.1-1.00.3-0.52.0
Intermitt. access day 1 inactive lever presses0.10.41.4-0.8-0.1-0.70.40.40.1-0.20.20.2-1.2-0.9-1.0
Intermitt. access day 15 inactive lever presses0.51.02.7-1.6-1.0-0.00.60.60.6-1.1-0.1-0.1-1.1-1.5-1.3
Intermitt. access escalation Index0.30.52.0-0.3-0.51.40.30.30.5-1.1-0.9-0.9-0.3-0.2-0.0
Intermittent access day 1 total infusions0.91.43.0-1.3-1.6-1.01.71.71.6-0.21.01.0-0.0-0.4-1.0
Intermittent access day 15 total infusions0.10.21.20.1-0.1-0.60.10.10.00.30.50.51.10.20.6
Intermittent access terminal intake (last 3 days)0.10.10.3-0.6-0.5-0.20.10.10.0-0.40.10.00.1-0.6-0.1
Intermittent access total infusions0.10.10.2-0.2-0.2-0.50.20.20.0-0.10.40.30.3-0.10.1
Intermittent access day 1 locomotion0.50.61.10.5-0.4-0.50.90.90.71.00.80.80.91.0-0.3
Intermittent access day 15 total locomotion0.61.12.10.6-0.4-1.30.80.80.71.41.41.41.31.30.3
Intermittent access total locomotion0.70.92.10.4-0.3-1.40.60.60.51.11.31.31.21.00.6
Intermittent access standard deviation0.51.02.80.71.30.3-1.5-1.5-1.7-0.3-0.7-0.70.0-0.21.1
Left kidney weight0.52.14.52.12.0-0.6-1.4-1.4-1.41.50.20.31.41.52.1
Right kidney weight0.20.82.80.71.0-1.3-0.8-0.8-0.70.70.50.70.50.51.7
Cocaine induced anxiety1.21.75.1-2.1-0.90.7-0.0-0.0-0.1-2.2-1.0-1.1-1.6-2.3-0.8
Post-drug Anxiety0.90.92.8-1.5-0.70.90.00.00.0-1.7-0.9-1.0-0.9-1.5-0.5
Baseline Anxiety0.60.72.01.30.60.1-0.2-0.20.11.20.30.41.31.41.0
Tail length0.72.75.52.22.30.8-2.1-2.1-1.90.8-0.9-0.71.21.02.1
Length with tail0.31.12.21.11.2-1.5-0.7-0.7-0.71.30.91.01.00.91.3
Length without tail0.51.77.5-0.5-0.6-2.71.01.00.71.02.02.00.20.1-0.4
Times rat made contact with spout0.40.51.20.80.4-0.70.40.40.31.10.80.80.70.8-0.3
Lifetime Intake0.10.10.2-0.4-0.0-0.3-0.1-0.1-0.3-0.40.00.0-0.1-0.50.2
Liver weight, left0.10.20.60.00.6-0.5-0.7-0.7-0.80.0-0.0-0.0-0.2-0.40.6
Liver weight, right0.40.83.20.30.0-1.80.50.50.30.91.21.30.60.70.8
Locomotor activity0.20.30.70.1-0.2-0.50.80.80.80.40.60.60.70.5-0.1
Locomotor testing distance0.10.10.4-0.3-0.20.10.50.50.6-0.10.10.10.2-0.2-0.3
Locomotor testing rearing0.51.11.8-0.20.90.7-1.3-1.3-1.4-1.0-1.2-1.1-1.0-1.20.4
Locomotion in novel chamber0.50.72.2-0.8-0.5-1.51.01.00.7-0.21.00.9-0.6-0.3-0.4
Locomotion in novel chamber post-restriction0.40.61.81.21.0-0.1-0.3-0.3-0.40.90.10.01.11.01.3
Fecal boli incidents, locomotor time 10.71.02.50.20.90.6-1.6-1.6-1.3-0.6-1.1-0.9-0.3-0.70.8
Change in fecal boli incidents, locomotor task0.50.51.5-0.5-0.10.70.10.1-0.4-0.9-0.7-0.8-1.2-0.7-1.0
Time >=10cm from walls, locomotor time 10.60.71.40.90.4-1.0-0.0-0.00.01.00.80.91.01.21.1
Bouts of movement, locomotor time 10.50.61.50.50.81.2-0.8-0.8-0.9-0.2-1.0-1.0-0.1-0.20.0
Total resting periods, locomotor time 10.40.41.40.20.51.2-0.6-0.6-0.6-0.3-0.9-1.0-0.0-0.4-0.3
Rest time, locomotor task time 10.20.20.90.60.60.1-0.6-0.6-0.30.70.10.11.00.30.3
Distance moved, locomotor task time 10.40.61.5-0.8-0.80.80.60.60.4-1.0-0.6-0.7-1.2-0.5-0.8
Vertical activity count, locomotor time 10.10.20.70.50.8-0.3-0.5-0.5-0.70.1-0.1-0.1-0.20.20.3
Time >=10cm from walls, locomotor time 20.81.22.20.3-0.7-1.41.11.11.11.11.51.51.01.20.2
Bouts of movement, locomotor time 20.10.20.7-0.2-0.30.90.50.50.4-0.2-0.4-0.5-0.0-0.1-0.6
Total resting periods, locomotor time 20.20.41.5-0.2-0.11.20.10.1-0.0-0.5-0.9-1.0-0.4-0.5-0.7
Rest time, locomotor task time 20.81.03.5-0.30.31.9-0.8-0.8-0.6-0.8-1.5-1.4-0.4-1.1-0.9
Distance moved, locomotor task time 21.01.22.2-0.7-1.3-1.31.51.51.50.21.21.20.00.60.3
Vertical activity count, locomotor time 20.40.52.40.30.6-1.6-0.5-0.5-0.60.30.70.8-0.20.31.2
Light reinforcement 15.413.327.54.45.21.9-5.2-5.2-4.90.8-2.6-2.30.91.63.9
Light reinforcement 25.07.715.93.64.01.8-3.9-3.9-3.50.9-2.0-1.71.11.52.7
Bone: marrow area0.00.10.3-0.4-0.30.1-0.3-0.3-0.3-0.2-0.2-0.2-0.6-0.4-0.1
Bone: maximum diameter0.10.20.6-0.7-0.7-0.70.50.50.3-0.10.50.4-0.2-0.5-0.4
Bone: maximum force0.40.61.51.00.8-1.00.20.2-0.21.20.90.90.90.90.0
Bone: maximum moment0.30.51.30.70.4-1.10.30.30.01.01.00.90.70.7-0.2
Mean time between licks in bursts0.10.30.8-0.9-0.4-0.3-0.2-0.2-0.0-0.9-0.1-0.1-0.4-0.80.5
Mean num. licks in bursts0.61.01.60.4-0.4-0.91.21.21.01.21.21.20.80.8-1.3
Cd content in liver2.62.96.2-2.5-2.11.40.70.70.5-2.3-1.2-1.4-2.4-2.2-1.2
Co content in liver0.81.02.8-1.7-1.6-0.41.01.00.8-0.80.30.2-1.0-1.1-0.8
Cu content in liver0.20.20.70.2-0.2-0.90.20.20.20.50.60.60.40.50.5
Fe content in liver4.45.312.03.11.7-1.7-0.3-0.3-0.03.41.92.03.53.42.4
K content in liver1.91.83.60.0-0.7-1.91.41.41.41.41.91.91.31.10.2
Mg content in liver0.91.02.2-0.5-0.8-1.51.11.11.10.61.41.40.50.3-0.3
Mn content in liver1.11.22.5-1.6-1.20.70.80.80.7-1.4-0.5-0.6-1.3-1.4-1.6
Na content in liver2.02.24.71.30.5-1.70.60.60.72.21.81.82.11.91.0
Rb content in liver0.40.50.90.90.8-0.9-0.6-0.6-0.60.90.50.60.60.60.5
Se content in liver3.03.58.02.51.6-2.0-0.2-0.2-0.32.81.81.92.32.61.4
Sr content in liver0.30.20.5-0.5-0.6-0.70.60.60.6-0.00.60.6-0.2-0.1-0.0
Zn content in liver1.11.23.0-1.4-1.7-0.41.51.51.6-0.40.60.6-0.4-0.5-1.1
Bone: minimum diameter0.40.71.91.41.2-0.5-0.7-0.7-0.91.00.20.30.70.80.6
Time in familiar zone, hab. session 10.40.40.90.60.9-0.5-0.7-0.7-0.90.40.10.1-0.10.31.0
Time in novel zone, hab. session 10.50.51.9-0.1-0.90.41.01.01.40.40.30.30.80.5-0.6
Total zone transitions, hab. session 10.20.20.6-0.7-0.70.5-0.1-0.10.0-0.8-0.4-0.4-0.5-0.6-0.2
Total locomotion distance, hab. session 10.40.61.3-0.9-1.10.90.40.40.4-0.9-0.5-0.5-0.7-0.8-0.9
Locomotion velocity, hab. session 10.40.61.2-0.9-1.11.10.20.20.3-1.1-0.8-0.8-0.8-0.9-0.7
Time in familiar zone, hab. session 21.51.62.80.41.31.4-1.6-1.6-1.7-1.0-1.6-1.5-1.0-0.80.3
Time in novel zone, hab. session 22.22.35.4-1.1-2.1-1.02.22.22.30.61.41.40.80.3-0.9
Total zone transitions, hab. session 20.30.40.8-0.40.00.7-0.6-0.6-0.6-0.8-0.8-0.8-0.9-0.7-0.2
Total locomotion distance, hab. session 20.30.51.4-0.5-0.41.2-0.3-0.3-0.0-0.9-1.0-0.9-0.6-0.7-0.3
Locomotion velocity, hab. session 20.20.31.1-0.1-0.11.1-0.5-0.5-0.2-0.6-0.9-0.8-0.2-0.30.1
Novel to familiar place preference ratio0.50.51.4-0.7-1.1-0.11.11.11.20.00.50.50.3-0.0-0.7
Novelty place preference0.40.41.1-0.6-0.90.00.90.91.00.20.50.40.40.0-0.6
Time in novel zone, NPP test0.60.61.5-0.3-0.8-0.41.01.01.20.60.90.90.90.5-0.3
Total zone transitions, NPP test0.10.10.5-0.5-0.1-0.7-0.2-0.2-0.2-0.20.20.3-0.6-0.5-0.1
Total locomotion distance, NPP test0.20.20.4-0.1-0.6-0.70.50.50.50.40.60.70.30.2-0.4
Locomotion velocity, NPP test0.10.10.5-0.3-0.3-0.60.20.20.00.10.40.4-0.2-0.3-0.7
Intraocular pressure2.63.78.3-2.7-2.91.21.91.92.1-2.1-0.6-0.7-1.6-1.8-2.1
Delta distance traveled before/after self-admin1.51.63.92.01.7-0.6-1.1-1.1-1.21.50.40.41.31.51.3
Delta ambulatory time before/after self-admin1.82.34.72.22.1-0.4-1.8-1.8-1.81.2-0.10.01.11.41.9
Parametrial fat weight0.40.82.5-1.10.00.0-0.6-0.6-0.8-1.3-0.7-0.7-1.5-1.60.1
Pavlov. Cond. lever latency0.30.30.9-0.60.00.5-0.2-0.2-0.2-0.8-0.6-0.6-0.9-0.9-0.3
Pavlov. Cond. magazine entry latency0.30.40.80.2-0.3-0.80.50.50.50.90.90.90.80.50.1
Pavlov. Cond. change in total contacts1.41.53.91.71.0-0.9-0.4-0.4-0.21.80.91.02.01.61.3
Pavlov. Cond. index score0.40.50.90.1-0.5-0.90.60.60.60.80.91.00.90.60.2
Pavlov. Cond. latency score0.10.20.3-0.1-0.5-0.50.40.40.40.50.60.60.40.2-0.0
Pavlov. Cond. lever contacts0.50.61.30.6-0.1-0.90.40.40.51.01.01.01.10.90.3
Pavlov. Cond. magazine entry number1.41.84.0-0.50.42.0-0.9-0.9-0.9-1.8-1.9-1.9-1.6-1.2-0.5
Pavlov. Cond. intertrial magazine entries0.20.20.9-0.5-0.20.60.00.00.3-1.0-0.6-0.5-0.6-0.4-0.1
Pavlov. Cond. lever-magazine prob. diff.0.50.61.1-0.0-0.7-1.00.70.70.80.91.01.10.90.60.2
Pavlov. Cond. response bias1.62.04.20.9-0.2-1.70.80.81.01.91.71.82.11.70.8
Pavlov. Cond. lever latency0.20.20.9-0.3-0.81.00.30.30.7-0.1-0.3-0.3-0.10.0-0.6
Pavlov. Cond. magazine entry latency0.10.20.4-0.20.4-0.5-0.4-0.4-0.6-0.5-0.1-0.1-0.3-0.40.6
Pavlov. Cond. change in total contacts0.20.31.80.00.3-1.30.10.1-0.10.20.70.80.30.20.7
Pavlov. Cond. index score0.20.21.40.00.5-1.20.10.1-0.20.10.60.60.20.10.6
Pavlov. Cond. latency score0.20.21.30.10.5-1.10.00.0-0.20.10.60.60.20.10.6
Pavlov. Cond. lever contacts0.30.41.20.61.1-0.9-0.6-0.6-0.90.10.20.20.20.10.8
Pavlov. Cond. magazine entry number0.10.10.70.2-0.20.8-0.0-0.00.10.0-0.4-0.4-0.20.1-0.5
Pavlov. Cond. intertrial magazine entries0.30.40.80.80.80.8-0.9-0.9-0.80.0-0.7-0.7-0.10.1-0.0
Pavlov. Cond. lever-magazine prob. diff.0.20.31.50.00.5-1.20.10.1-0.20.10.60.60.20.10.7
Pavlov. Cond. response bias0.30.31.60.30.8-1.3-0.2-0.2-0.50.20.60.60.30.20.8
Time in closed arm before self-admin1.92.55.42.32.1-0.3-1.7-1.7-1.51.40.00.21.51.62.2
Time in closed arm after self-admin1.01.02.61.51.20.2-1.1-1.1-0.90.8-0.2-0.11.01.11.6
Time in open arm before self-admin1.21.33.3-1.8-1.5-0.71.11.10.8-0.90.40.3-1.3-1.3-1.3
Time in open arm after self-admin0.60.71.1-0.9-1.1-0.71.11.11.0-0.10.70.6-0.5-0.3-1.0
Bone: periosteal estimation0.00.10.20.30.3-0.4-0.3-0.3-0.40.30.10.20.1-0.0-0.0
Bone: periosteal perimeter0.10.20.9-0.7-0.10.3-0.2-0.2-0.2-0.6-0.4-0.4-0.5-1.0-0.4
Bone: post-yield work0.10.10.5-0.2-0.30.5-0.1-0.1-0.2-0.1-0.3-0.4-0.3-0.6-0.7
Progressive ratio test 1 active lever presses0.60.82.50.3-0.2-1.60.40.40.21.01.21.21.10.80.5
Progressive ratio test 1 breakpoint0.70.82.60.3-0.2-1.60.50.50.31.11.31.31.10.80.5
Progressive ratio test 1 inactive lever presses0.50.73.8-0.4-0.3-1.90.70.70.30.61.41.30.1-0.1-0.3
Progressive ratio test 2 active lever presses0.30.31.2-0.1-0.4-1.10.40.40.20.50.90.90.50.30.1
Progressive ratio test 2 breakpoint0.20.30.9-0.1-0.5-0.90.50.50.30.40.80.80.50.2-0.1
Progressive ratio test 2 inactive lever presses0.50.92.1-1.4-1.3-0.41.01.00.8-0.80.40.3-0.7-1.0-1.1
Incentive Sensitization - Responses0.10.10.4-0.5-0.30.1-0.0-0.0-0.2-0.6-0.2-0.2-0.4-0.6-0.4
Incentive Sensitization - Breakpoint0.10.10.4-0.4-0.20.3-0.1-0.1-0.3-0.6-0.3-0.3-0.5-0.6-0.4
Sum of active levers in priming session hrs 5-60.30.30.6-0.6-0.40.80.20.20.3-0.6-0.5-0.5-0.6-0.7-0.8
Progressive ratio0.20.31.20.60.71.1-0.5-0.5-0.4-0.1-0.7-0.70.10.1-0.4
Food seeking constrained by brief footshock1.92.34.21.41.81.7-2.0-2.0-2.0-0.5-1.8-1.7-0.10.21.1
Seeking ratio, punishment vs. effort0.50.72.20.91.0-0.6-1.1-1.1-1.10.50.00.10.40.61.5
Retroperitoneal fat weight0.52.36.6-2.4-1.20.00.30.3-0.1-2.1-0.6-0.7-2.3-2.6-1.5
Reaction time number correct0.30.51.5-0.7-0.9-0.01.21.21.2-0.40.30.3-0.2-0.1-0.6
Reaction time mean minus median1.43.67.1-0.2-1.4-2.72.12.12.01.72.62.61.11.0-1.3
Reaction time mean minus median AUC1.33.26.5-0.5-1.5-2.62.02.01.91.52.52.40.90.6-1.2
Reaction time num false alarms2.43.310.0-3.2-2.7-0.71.61.61.6-1.90.40.3-2.0-2.1-1.4
Reaction time num false alarms AUC1.82.98.5-2.9-2.5-0.31.41.41.4-1.90.10.1-1.9-2.0-1.4
Reaction time trials correct on left0.30.51.5-0.7-0.9-0.01.21.21.2-0.40.30.3-0.2-0.1-0.6
Reaction time trials on left0.30.71.8-0.8-1.0-0.11.31.31.3-0.40.40.3-0.2-0.1-0.7
Reaction time mean3.04.78.1-1.2-2.5-2.82.72.72.71.32.82.80.60.6-1.1
Reaction time mean AUC2.74.47.1-1.3-2.5-2.72.62.62.61.22.72.60.50.5-1.0
Median of all reaction times2.53.55.8-1.2-2.3-2.32.42.42.41.02.42.30.40.4-0.8
Reaction time omissions1.92.85.2-1.6-1.8-2.32.12.11.90.12.01.9-0.6-0.5-1.5
Reaction time false alarm rate1.01.34.5-2.1-1.6-0.20.50.50.6-1.5-0.1-0.2-1.6-1.7-0.7
Reaction time premature initiation rate3.34.69.40.82.41.9-3.0-3.0-3.1-1.4-2.4-2.4-1.4-1.11.1
Reaction time premature initiations1.42.54.20.21.61.6-2.0-2.0-2.1-1.5-2.0-1.9-1.4-1.10.5
Std. dev. reaction times1.73.16.7-0.6-1.6-2.62.02.02.01.42.52.50.70.7-0.9
Reaction time trials completed0.30.71.8-0.8-1.0-0.11.31.31.3-0.40.40.3-0.2-0.1-0.7
Reaction time trials AUC0.40.71.8-0.8-1.1-0.11.31.31.3-0.40.40.4-0.2-0.1-0.7
Run reversals in cocaine runway, females0.40.40.9-0.2-0.5-0.90.60.60.70.40.80.80.50.30.0
Run reversals in cocaine runway, males0.30.30.8-0.0-0.4-0.20.80.80.70.50.40.40.90.4-0.1
Latency to leave start box in cocaine runway0.40.41.2-0.8-0.71.10.30.30.6-0.8-0.8-0.8-0.5-0.6-0.0
Latency to leave start box in cocaine runway, F0.60.62.2-0.3-1.00.21.31.31.50.50.40.40.60.3-0.5
Latency to leave start box in cocaine runway, M2.72.54.4-0.80.41.8-1.5-1.5-1.3-2.0-2.1-2.0-1.8-1.70.7
Std. dev. time between licks in bursts0.20.30.90.20.40.3-0.7-0.7-0.6-0.4-0.5-0.40.10.01.0
Total sessions with >9 infusions0.00.10.10.1-0.2-0.20.20.20.20.20.20.20.40.30.2
Short access day 1 total inactive lever presses0.30.41.30.30.3-1.20.10.1-0.10.60.70.81.00.51.0
Short access day 10 total inactive lever presses0.10.20.7-0.00.8-0.3-0.5-0.5-0.7-0.5-0.3-0.3-0.6-0.50.4
Short access day 1 total infusions0.30.30.8-0.8-0.9-0.30.80.80.8-0.30.30.3-0.1-0.3-0.5
Short access day 10 total infusions0.10.10.3-0.4-0.10.10.10.1-0.1-0.4-0.2-0.3-0.4-0.5-0.4
Short access total infusions0.10.10.3-0.5-0.3-0.30.10.10.0-0.40.10.1-0.0-0.50.1
Short access day 1 locomotion1.11.43.2-1.2-1.7-0.01.61.61.5-0.40.50.4-0.6-0.4-1.8
Short access day 10 total locomotion0.00.10.3-0.1-0.4-0.10.50.50.30.10.20.20.30.1-0.0
Short access total locomotion0.20.30.8-0.6-0.90.20.80.80.6-0.30.10.0-0.2-0.3-0.7
One hour access (0.3 mA shock)1.21.44.1-1.6-0.60.9-0.1-0.1-0.2-1.7-0.9-1.0-1.6-2.0-1.4
Compulsive drug intake0.60.71.9-0.7-0.21.4-0.2-0.2-0.0-0.9-1.0-1.0-0.8-1.2-1.3
One hour access (shock baseline)0.30.41.0-0.9-0.50.20.20.2-0.0-0.9-0.2-0.3-0.9-1.0-0.9
Social response proportion0.30.40.90.0-0.4-1.00.50.50.50.60.80.80.60.60.6
Social responses0.91.13.1-1.3-0.40.9-0.3-0.3-0.4-1.8-1.2-1.2-1.5-1.50.1
Social time0.30.40.80.90.80.8-0.6-0.6-0.50.1-0.7-0.60.10.60.6
Soleus weight0.20.51.2-0.6-0.10.6-0.5-0.5-0.5-1.0-0.7-0.7-0.9-1.1-0.6
Bone: stiffness0.71.12.41.00.7-1.50.30.30.21.61.31.41.41.00.4
Tibialis anterior weight0.61.93.2-0.7-1.2-1.71.81.81.70.91.81.71.00.3-0.7
Time to tail flick, vehicle, before self-admin1.41.45.6-0.4-0.22.4-0.5-0.5-0.4-1.3-1.7-1.8-1.1-0.9-0.7
Time to tail flick, vehicle, after self-admin1.31.73.3-0.20.61.8-1.4-1.4-1.4-1.2-1.8-1.8-1.3-1.2-0.4
Time to tail flick, test, before self-admin0.60.71.4-1.2-1.20.90.50.50.7-1.1-0.6-0.6-0.7-0.8-0.5
Time to tail flick, test, after self-admin0.70.72.31.51.0-0.0-0.2-0.2-0.31.30.30.31.21.20.3
Delta time to tail flick, vehicle, before/after SA0.30.30.70.10.60.2-0.8-0.8-0.8-0.3-0.5-0.4-0.2-0.30.4
Delta time to tail flick, test, before/after SA3.13.17.62.41.3-2.00.20.20.12.81.91.92.32.50.8
Tibia length1.74.610.61.2-0.1-3.31.61.61.32.73.03.02.62.10.2
Ambulatory time before self-admin1.42.04.6-1.3-1.9-1.32.02.02.20.31.51.50.30.0-0.7
Ambulatory time after self-admin1.41.63.41.30.5-1.40.00.00.21.81.41.51.81.71.3
Bone: tissue strength0.30.31.00.1-0.0-1.00.40.40.20.50.80.80.50.50.4
Total heroin consumption0.20.20.8-0.9-0.5-0.1-0.2-0.20.0-0.5-0.00.0-0.6-0.9-0.0
Bone: trabecular number0.81.43.71.91.71.7-1.0-1.0-0.90.7-1.0-0.90.91.0-0.3
Bone: trabecular spacing0.70.92.8-1.7-1.7-0.90.80.80.8-0.90.50.4-0.6-0.80.5
Bone: trabecular thickness1.82.38.22.92.10.3-0.9-0.9-0.91.90.20.21.82.20.5
Bone: trabecular tissue density0.20.41.5-0.6-1.20.00.80.81.0-0.40.20.2-0.10.0-0.1
Water consumed over 24 hours0.91.33.31.61.8-0.0-1.5-1.5-1.60.8-0.2-0.20.50.71.0
Number of responses in last shaping day1.41.53.3-1.7-1.50.21.11.10.8-1.3-0.1-0.2-1.6-1.4-1.8