Hub : Genes

Tekt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Tekt1 0.04 0.03 2.2e-05 0.04 0.03 0.03 0.03 3.7e-06 3.0e-05 1.6e-05 1.4e-05
2 PL gene expression Tekt1 0.08 0.05 1.2e-07 0.06 0.06 0.07 0.07 1.9e-07 4.0e-07 3.1e-08 4.8e-08
3 Adipose gene expression Tekt1 0.04 0.03 1.7e-04 0 0.01 0.01 0.01 1.5e-01 8.4e-03 2.9e-02 4.5e-02
4 RMTg gene expression Tekt1 0.12 0.09 8.5e-03 0.02 0.05 0 0.05 1.0e-01 1.7e-02 2.4e-01 2.0e-02
5 BLA gene expression Tekt1 0.07 0.05 5.8e-03 0.01 0.03 0.02 0.02 7.1e-02 8.5e-03 1.8e-02 2.3e-02
6 Brain gene expression Tekt1 0.07 0.05 2.1e-06 0.04 0.07 0.07 0.06 1.4e-04 6.9e-07 7.0e-07 1.3e-06
7 pVTA gene expression Tekt1 0.11 0.06 5.9e-09 0.1 0.05 0.1 0.1 1.4e-08 3.4e-05 4.9e-08 1.0e-08
8 NAcc gene expression Tekt1 0.11 0.08 1.7e-10 0.06 0.07 0.07 0.07 4.1e-09 2.1e-10 2.1e-10 1.8e-10
9 LHb gene expression Tekt1 0.22 0.14 1.6e-03 0.07 0.08 0.04 0.07 9.8e-03 6.7e-03 3.9e-02 8.7e-03
10 IC gene expression Tekt1 0.07 0.06 5.6e-03 0.05 0.04 0.05 0.05 4.3e-03 9.5e-03 3.3e-03 4.5e-03
11 PL mRNA stability Tekt1 0.03 0.02 3.3e-03 0.02 0.01 0.03 0.01 2.5e-03 1.3e-02 8.4e-04 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.11.93.6-0.91.11.11.31.21.61.91.71.81.10.8
Area under the delay curve0.10.10.30.4-0.2-0.2-0.3-0.2-0.4-0.6-0.4-0.5-0.2-0.0
BMI with tail0.31.01.50.71.21.21.11.21.21.00.81.01.00.6
BMI without tail1.44.26.5-0.72.01.71.91.82.32.62.42.52.41.5
Body weight2.310.215.3-1.22.92.83.02.93.43.93.93.83.42.9
Weight adjusted by age0.50.72.51.60.91.11.01.00.70.1-0.60.2-0.40.3
Bone surface0.81.52.50.31.11.51.61.51.61.31.21.50.20.3
Bone volume1.12.03.10.51.51.71.81.71.71.41.31.50.70.8
Breakpoint value in progressive ratio session1.21.52.80.31.31.41.51.41.51.71.21.40.50.4
Number of licking bursts0.40.62.5-0.1-0.9-0.6-0.6-0.6-0.6-0.4-0.6-0.5-1.2-1.6
Context. condit. distance diff. score1.31.62.30.71.51.51.51.51.51.21.01.31.11.0
Locomotion velocity, session 13.84.14.90.12.22.12.12.12.22.12.12.22.12.0
Locomotion distance, session 10.60.71.10.81.11.11.01.00.90.50.50.60.60.8
Locomotion velocity, session 20.40.51.3-1.20.30.10.20.20.50.91.00.81.00.5
Locomotion distance, session 20.40.60.9-0.20.80.70.80.80.90.90.90.90.90.7
Locomotion velocity, session 31.82.13.8-1.3-1.9-1.7-1.7-1.6-1.5-1.0-0.6-1.1-1.4-1.4
Locomotion distance, session 30.10.10.3-0.2-0.5-0.4-0.4-0.4-0.3-0.2-0.1-0.2-0.4-0.6
Stereotopy head waving bouts, day 30.00.00.2-0.4-0.10.10.10.10.20.30.40.3-0.00.0
Stereotopy head waving duration, day 30.50.61.20.8-0.6-0.4-0.5-0.4-0.8-1.1-0.9-1.0-1.0-0.5
Locomotion velocity, session 70.00.10.30.60.10.10.10.10.1-0.1-0.3-0.10.0-0.3
Locomotion distance, session 70.00.00.20.3-0.0-0.1-0.0-0.1-0.00.0-0.3-0.1-0.1-0.5
Stereotopy head waving bouts, day 71.51.72.60.91.61.61.51.51.41.00.91.21.11.1
Stereotopy head waving duration, day 71.11.31.90.71.41.41.41.41.30.91.01.11.01.0
Locomotion velocity, session 80.70.81.40.90.91.21.11.21.00.60.90.80.30.3
Locomotion distance, session 82.43.44.50.52.02.02.02.02.11.91.92.01.81.5
Degree of sensitization distance0.50.51.10.81.00.80.80.70.70.40.00.40.70.7
Degree of sensitization stereotypy1.71.92.60.41.61.51.51.51.51.31.21.41.41.2
Conditioned locomotion0.91.01.5-0.4-1.2-1.2-1.2-1.2-1.1-1.0-0.9-1.0-0.9-0.9
Cocaine response after cond. corrected0.30.41.5-1.20.1-0.2-0.1-0.10.20.80.70.60.90.7
Cocaine response after cond. not corrected0.30.40.9-0.90.40.10.20.20.40.90.70.70.90.7
Cocaine response before conditioning0.40.51.01.01.01.00.90.90.80.40.30.50.30.3
Saline control response0.50.61.41.21.10.90.90.90.70.2-0.10.40.50.7
Bone: connectivity density1.72.63.9-0.41.61.61.71.61.92.01.82.01.41.3
Bone: cortical apparent density1.21.72.8-0.9-1.5-1.7-1.6-1.7-1.5-1.1-1.1-1.2-0.7-0.7
Bone: cortical area0.30.51.00.4-0.6-0.5-0.6-0.6-0.7-1.0-0.8-0.8-0.7-0.4
Bone: cortical porosity0.80.93.8-2.0-0.0-0.3-0.2-0.20.31.11.10.81.31.1
Bone: cortical porosity0.50.52.9-1.7-0.3-0.5-0.4-0.4-0.00.70.80.40.80.6
Bone: cortical thickness1.42.33.9-1.5-1.8-2.0-1.9-1.9-1.7-1.2-1.0-1.3-0.7-0.9
Bone: cortical thickness1.01.25.7-2.4-1.1-1.4-1.3-1.3-0.80.10.2-0.10.50.1
Bone: cortical tissue density1.01.32.3-0.9-1.3-1.5-1.5-1.5-1.3-0.9-1.0-1.1-0.6-0.5
Condit. Reinf. active minus inactive responses0.20.31.6-1.3-0.3-0.6-0.4-0.5-0.10.50.10.20.40.1
Condit. Reinf. active-inactive response ratio0.20.20.9-0.9-0.2-0.5-0.4-0.4-0.10.4-0.00.10.30.3
Condit. Reinf. active responses0.20.21.5-1.2-0.1-0.4-0.3-0.40.00.60.10.30.60.3
Condit. Reinf. inactive responses0.00.00.1-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.0-0.2
Incentive salience index mean0.50.63.0-1.7-0.0-0.5-0.3-0.40.20.90.50.61.00.6
Condit. Reinf. lever presses1.21.75.0-2.20.50.00.20.10.81.71.41.31.81.5
Condit. Reinf. active minus inactive responses0.20.21.2-1.1-0.2-0.3-0.2-0.30.10.60.40.40.30.0
Condit. Reinf. active-inactive response ratio0.30.31.8-1.3-0.4-0.6-0.5-0.6-0.20.40.10.10.20.2
Condit. Reinf. active responses0.10.10.4-0.6-0.2-0.2-0.1-0.10.10.40.30.30.0-0.2
Condit. Reinf. inactive responses0.20.20.80.9-0.10.10.00.0-0.2-0.4-0.4-0.3-0.7-0.9
Condit. Reinf. lever presses0.91.21.60.1-1.1-1.1-1.1-1.1-1.2-1.1-1.3-1.2-1.2-1.3
Condit. Reinf. lever reinforcers received0.00.10.2-0.5-0.3-0.3-0.2-0.3-0.10.20.00.1-0.2-0.4
Conditioned reinforcement - actives0.30.60.80.60.90.90.90.90.80.60.70.60.60.7
Conditioned reinforcement - inactives1.31.96.42.51.61.91.81.71.3-0.0-0.20.6-0.3-0.2
Conditioned locomotion0.70.94.82.20.20.40.20.3-0.4-1.4-1.0-0.9-0.7-0.3
Patch foraging indifference point 0 sec0.30.52.0-1.4-0.7-1.0-0.9-1.0-0.50.5-0.0-0.0-0.0-0.5
Patch foraging indifference point AUC0.30.51.91.40.20.20.10.1-0.3-0.8-1.1-0.8-0.80.1
Delay disc. indifference point, 0s delay1.11.22.11.41.51.31.31.31.00.40.40.60.91.1
Delay disc. indifference point, 16s delay0.20.20.70.6-0.0-0.1-0.2-0.1-0.5-0.8-0.2-0.60.10.3
Delay disc. indifference point, 2s delay0.20.20.3-0.1-0.4-0.5-0.5-0.5-0.5-0.4-0.4-0.4-0.1-0.4
Delay disc. indifference point, 24s delay0.50.61.1-0.8-1.0-0.9-0.9-0.8-0.7-0.4-0.2-0.5-0.8-0.9
Delay disc. indifference point, 4s delay0.20.20.70.80.40.50.50.40.3-0.0-0.30.0-0.3-0.0
Delay disc. indifference point, 8s delay0.00.00.10.1-0.1-0.1-0.1-0.1-0.2-0.2-0.1-0.20.00.1
Indifference point function ln k1.11.89.4-3.1-1.4-1.5-1.3-1.3-0.50.71.20.50.7-0.6
Indifference point function log k1.11.89.4-3.1-1.4-1.5-1.3-1.3-0.50.71.20.50.7-0.6
Patch foraging total patch changes 0 sec0.20.41.3-1.2-0.5-0.9-0.7-0.8-0.40.5-0.1-0.0-0.0-0.5
Patch foraging total patch changes 12 sec0.30.31.61.30.80.60.60.50.30.0-0.7-0.1-0.20.2
Patch foraging total patch changes 18 sec0.10.10.40.60.60.30.40.30.20.1-0.4-0.00.00.6
Patch foraging total patch changes 24 sec0.10.20.90.90.0-0.1-0.1-0.1-0.3-0.5-0.8-0.5-0.5-0.2
Patch foraging total patch changes 6 sec0.40.62.81.70.30.20.10.0-0.3-0.8-1.4-0.8-0.8-0.1
Patch foraging time to switch 0 sec0.81.52.71.61.61.61.61.61.30.50.30.70.61.1
Patch foraging water rate 0 sec0.61.22.1-0.6-1.4-1.3-1.3-1.3-1.1-0.8-0.7-0.9-0.7-1.5
Patch foraging water rate 12 sec0.30.71.00.50.91.01.01.01.00.80.60.90.90.3
Patch foraging water rate 18 sec0.50.71.8-0.90.30.30.40.40.81.21.31.11.2-0.1
Patch foraging water rate 24 sec0.10.21.30.6-0.20.20.10.10.0-0.3-0.2-0.1-0.1-1.1
Patch foraging water rate 6 sec0.30.41.9-0.0-0.8-0.6-0.6-0.5-0.5-0.6-0.1-0.3-0.3-1.4
Seeking ratio, delayed vs. immediate footshock0.60.71.1-0.5-1.0-1.0-1.0-1.0-1.0-0.7-0.6-0.8-0.7-0.5
Distance traveled before self-admin0.50.71.81.1-0.2-0.4-0.5-0.5-0.9-1.3-1.1-1.2-0.30.4
Distance traveled after self-admin1.72.17.92.81.71.81.61.70.9-0.6-0.5-0.00.11.7
Extensor digitorum longus weight2.08.013.13.33.63.63.53.52.81.41.31.92.02.7
Bone: elastic displacement0.60.81.2-0.0-0.7-1.0-1.0-1.0-1.1-1.0-1.1-1.1-0.2-0.1
Bone: elastic work1.51.93.0-0.9-1.5-1.7-1.7-1.7-1.6-1.4-1.2-1.4-0.8-0.7
Bone: endosteal estimation0.91.99.53.11.21.71.51.60.8-0.5-0.5-0.0-1.0-0.2
Bone: endosteal perimeter0.91.98.22.91.41.81.71.71.0-0.3-0.30.2-0.80.1
Epididymis fat weight5.920.329.51.75.45.05.15.05.04.13.74.44.64.5
Delta time in closed arm before/after self-admin0.10.10.30.60.20.30.20.20.0-0.20.2-0.1-0.10.1
Delta time in open arm before/after self-admin0.40.40.80.60.90.70.70.60.60.5-0.20.40.40.7
Diff in mean of infusions in LGA sessions1.11.32.3-0.31.11.11.21.11.31.51.41.41.00.6
Delay discount exponential model param0.10.10.2-0.20.30.30.30.30.40.50.30.40.30.3
Extinction: sum of active levers before priming1.92.04.30.41.71.61.61.61.51.31.01.31.12.1
Active lever presses in extinction session 62.92.96.5-0.21.81.61.61.61.61.61.71.61.82.5
Bone: final force0.10.20.40.50.30.50.50.50.3-0.1-0.20.1-0.6-0.2
Bone: final moment0.10.20.50.70.30.50.40.40.2-0.3-0.4-0.1-0.6-0.2
Food consumed during 24 hour testing period0.20.31.3-1.1-0.1-0.3-0.3-0.2-0.00.40.80.41.00.5
Glucose3.55.58.10.6-2.2-2.2-2.3-2.3-2.5-2.5-2.8-2.7-2.2-2.6
Heart weight1.31.92.60.31.51.51.61.51.61.51.41.51.31.1
Delay discount hyperbolic model param0.10.10.2-0.10.40.30.30.30.40.40.30.40.40.4
Intermittent access intake day 1-15 change0.50.92.71.6-0.2-0.1-0.3-0.2-0.8-1.5-1.5-1.3-0.50.5
Intermittent access intake escalation0.61.23.51.9-0.1-0.1-0.3-0.3-0.9-1.7-1.8-1.4-0.70.6
Intermittent access intake escalation 21.31.53.21.1-0.8-0.8-1.0-0.9-1.3-1.8-1.8-1.7-0.90.0
Intermitt. access day 1 inactive lever presses1.03.98.21.8-1.3-1.0-1.1-1.1-1.5-2.4-2.9-2.1-2.8-2.6
Intermitt. access day 15 inactive lever presses0.30.72.30.6-0.7-0.3-0.4-0.4-0.5-0.9-1.1-0.8-1.5-1.2
Intermitt. access escalation Index0.60.82.2-0.40.80.70.80.70.91.51.11.10.90.7
Intermittent access day 1 total infusions0.81.33.71.91.51.51.51.51.00.10.00.50.10.7
Intermittent access day 15 total infusions1.52.211.93.41.51.61.41.40.6-1.0-1.1-0.5-0.51.1
Intermittent access terminal intake (last 3 days)1.72.28.62.91.81.81.71.71.0-0.4-0.40.10.31.5
Intermittent access total infusions1.41.76.12.51.51.51.41.40.8-0.5-0.40.00.41.5
Intermittent access day 1 locomotion0.91.24.02.01.21.51.41.41.00.10.10.5-0.3-0.1
Intermittent access day 15 total locomotion0.71.37.62.80.81.21.01.10.4-1.0-0.7-0.3-0.60.1
Intermittent access total locomotion0.91.15.22.30.91.31.11.20.6-0.6-0.4-0.0-0.40.4
Intermittent access standard deviation0.91.910.63.30.91.21.01.10.1-1.3-1.3-0.9-1.00.7
Left kidney weight0.00.10.20.1-0.00.20.10.2-0.0-0.5-0.1-0.1-0.30.4
Right kidney weight0.10.30.6-0.20.50.60.60.60.60.20.60.60.60.8
Cocaine induced anxiety0.20.30.6-0.7-0.8-0.6-0.6-0.6-0.5-0.4-0.3-0.4-0.6-0.4
Post-drug Anxiety0.70.82.0-1.20.60.20.40.30.61.10.80.91.41.3
Baseline Anxiety1.21.42.8-0.21.40.91.00.91.21.51.01.21.71.1
Tail length2.38.914.5-1.62.62.42.62.63.13.73.83.63.22.6
Length with tail2.19.116.0-2.02.52.42.62.63.13.84.03.73.22.8
Length without tail1.34.37.0-0.91.91.92.02.02.22.52.62.42.01.9
Times rat made contact with spout0.40.41.7-1.3-0.7-0.9-0.8-0.8-0.50.20.1-0.10.1-0.1
Lifetime Intake1.82.28.22.91.81.91.81.81.1-0.3-0.40.20.21.3
Liver weight, left4.47.312.8-2.12.22.02.22.12.73.33.63.33.12.5
Liver weight, right5.08.811.5-0.73.02.93.03.03.33.33.33.42.92.8
Locomotor activity0.30.51.31.11.01.00.90.90.80.2-0.00.40.30.2
Locomotor testing distance1.12.05.92.41.91.91.81.71.30.2-0.20.50.60.9
Locomotor testing rearing0.81.77.12.71.61.51.41.40.8-0.3-0.8-0.00.20.9
Locomotion in novel chamber1.82.36.02.0-0.6-0.8-1.0-0.9-1.5-2.5-2.4-2.0-0.9-0.5
Locomotion in novel chamber post-restriction0.20.30.6-0.2-0.5-0.8-0.7-0.8-0.7-0.6-0.6-0.7-0.2-0.1
Fecal boli incidents, locomotor time 10.10.20.5-0.7-0.4-0.5-0.5-0.4-0.4-0.10.2-0.20.40.3
Change in fecal boli incidents, locomotor task0.40.41.3-0.5-0.8-0.6-0.5-0.6-0.4-0.2-0.4-0.3-1.1-1.1
Time >=10cm from walls, locomotor time 10.00.10.2-0.5-0.3-0.2-0.2-0.2-0.00.30.30.2-0.0-0.0
Bouts of movement, locomotor time 10.30.41.6-1.3-0.0-0.3-0.2-0.20.00.50.60.31.00.7
Total resting periods, locomotor time 10.50.63.2-1.8-0.7-0.9-0.8-0.8-0.40.30.50.10.50.1
Rest time, locomotor task time 10.81.01.8-0.7-1.4-1.2-1.2-1.2-1.1-0.8-0.6-0.9-1.0-0.9
Distance moved, locomotor task time 10.30.51.11.01.00.90.90.90.70.30.00.40.30.2
Vertical activity count, locomotor time 10.30.71.31.11.11.11.11.00.90.60.20.60.50.2
Time >=10cm from walls, locomotor time 20.20.20.6-0.6-0.8-0.6-0.6-0.6-0.4-0.00.1-0.1-0.6-0.5
Bouts of movement, locomotor time 20.30.41.9-1.4-0.8-0.8-0.8-0.8-0.40.10.0-0.1-0.3-0.3
Total resting periods, locomotor time 20.20.31.5-1.2-0.5-0.6-0.5-0.5-0.20.30.30.10.00.1
Rest time, locomotor task time 20.50.61.4-0.9-1.2-1.0-1.0-0.9-0.8-0.3-0.1-0.5-0.7-0.7
Distance moved, locomotor task time 20.60.73.11.81.21.00.90.90.5-0.2-0.40.00.40.6
Vertical activity count, locomotor time 20.40.51.21.11.00.90.90.80.70.20.00.40.60.3
Light reinforcement 10.51.35.22.31.51.41.31.30.9-0.1-0.40.20.40.4
Light reinforcement 20.10.10.50.70.20.10.10.1-0.1-0.5-0.5-0.3-0.1-0.2
Bone: marrow area0.81.89.13.01.21.71.51.50.8-0.5-0.5-0.0-0.9-0.2
Bone: maximum diameter0.20.42.51.60.20.40.30.3-0.1-0.9-0.7-0.5-0.7-0.1
Bone: maximum force0.20.31.01.00.40.70.60.60.4-0.2-0.30.0-0.6-0.2
Bone: maximum moment0.20.31.61.30.40.60.50.50.2-0.4-0.5-0.2-0.5-0.2
Mean time between licks in bursts1.22.84.00.82.01.81.81.81.71.41.51.51.81.9
Mean num. licks in bursts0.30.41.9-0.60.40.10.10.10.30.50.50.41.11.4
Cd content in liver0.80.93.01.71.01.31.21.20.90.10.10.4-0.10.1
Co content in liver0.40.41.3-0.20.60.40.40.50.50.50.70.60.91.2
Cu content in liver1.21.42.3-1.4-1.5-1.5-1.4-1.5-1.1-0.4-0.5-0.7-0.9-1.4
Fe content in liver0.91.01.4-0.21.01.11.11.11.21.11.11.20.80.9
K content in liver0.80.81.8-0.90.50.60.60.60.81.01.31.10.91.0
Mg content in liver0.10.10.6-0.7-0.3-0.3-0.3-0.3-0.10.20.30.10.10.1
Mn content in liver0.70.73.3-1.8-0.9-1.1-1.0-1.0-0.70.10.3-0.10.2-0.1
Na content in liver0.10.10.20.3-0.0-0.1-0.2-0.1-0.3-0.5-0.3-0.40.20.3
Rb content in liver0.50.61.11.01.01.11.01.00.80.40.20.50.30.5
Se content in liver0.60.71.5-0.4-1.1-0.9-0.9-0.9-0.8-0.6-0.6-0.7-1.1-1.2
Sr content in liver1.21.11.60.91.31.21.21.21.00.70.60.81.01.2
Zn content in liver0.30.30.9-0.60.30.40.50.40.70.90.80.80.2-0.1
Bone: minimum diameter0.61.14.42.11.21.41.31.40.8-0.10.00.3-0.10.4
Time in familiar zone, hab. session 10.20.20.50.7-0.1-0.1-0.1-0.1-0.3-0.5-0.7-0.5-0.4-0.5
Time in novel zone, hab. session 10.10.10.6-0.8-0.1-0.1-0.1-0.00.10.50.60.40.40.3
Total zone transitions, hab. session 11.62.39.63.11.91.91.81.81.2-0.1-0.30.30.40.6
Total locomotion distance, hab. session 10.20.30.70.80.80.60.60.60.50.2-0.00.30.60.2
Locomotion velocity, hab. session 10.20.30.91.00.70.60.60.50.40.0-0.20.10.40.3
Time in familiar zone, hab. session 20.20.20.8-0.90.1-0.00.00.00.20.50.50.40.30.6
Time in novel zone, hab. session 20.50.51.20.3-0.7-0.7-0.7-0.7-0.7-0.7-0.9-0.8-0.6-1.1
Total zone transitions, hab. session 21.31.73.11.71.71.71.61.61.30.60.40.80.90.9
Total locomotion distance, hab. session 20.30.30.80.80.90.70.70.70.60.30.10.30.60.4
Locomotion velocity, hab. session 20.20.30.70.80.80.70.70.70.50.20.10.30.50.4
Novel to familiar place preference ratio0.20.20.40.6-0.2-0.1-0.2-0.2-0.3-0.5-0.7-0.5-0.4-0.5
Novelty place preference0.00.00.10.3-0.0-0.0-0.0-0.0-0.1-0.1-0.3-0.1-0.1-0.3
Time in novel zone, NPP test0.00.00.00.20.10.10.10.10.10.1-0.10.10.1-0.1
Total zone transitions, NPP test1.31.95.22.31.81.81.71.71.20.30.00.50.70.9
Total locomotion distance, NPP test0.20.21.01.00.10.00.0-0.0-0.2-0.6-0.8-0.5-0.2-0.3
Locomotion velocity, NPP test0.40.61.41.0-0.3-0.4-0.5-0.5-0.7-1.1-1.2-1.0-0.7-0.7
Intraocular pressure0.81.23.61.8-0.1-0.2-0.3-0.3-0.7-1.6-1.9-1.3-1.0-0.2
Delta distance traveled before/after self-admin2.72.95.11.52.12.32.22.21.91.00.81.40.81.5
Delta ambulatory time before/after self-admin1.41.72.90.91.61.71.71.71.50.90.51.10.71.5
Parametrial fat weight8.620.330.42.05.55.15.15.15.04.03.44.24.54.5
Pavlov. Cond. lever latency0.50.73.82.00.61.00.80.90.4-0.4-0.1-0.1-0.5-0.3
Pavlov. Cond. magazine entry latency0.91.27.5-2.7-0.8-1.0-0.9-0.9-0.30.80.80.50.60.3
Pavlov. Cond. change in total contacts1.21.32.4-1.4-1.3-1.6-1.5-1.5-1.2-0.5-0.8-0.8-0.5-0.8
Pavlov. Cond. index score0.70.95.5-2.3-0.3-0.7-0.5-0.6-0.00.90.70.60.90.7
Pavlov. Cond. latency score0.81.16.3-2.5-0.2-0.6-0.4-0.50.11.10.90.81.00.8
Pavlov. Cond. lever contacts0.50.63.8-1.9-0.5-0.9-0.7-0.8-0.30.50.10.10.60.4
Pavlov. Cond. magazine entry number0.50.73.51.90.81.10.91.00.5-0.3-0.10.0-0.2-0.1
Pavlov. Cond. intertrial magazine entries1.01.26.42.51.21.21.11.10.6-0.4-0.6-0.10.10.1
Pavlov. Cond. lever-magazine prob. diff.0.60.85.1-2.3-0.5-0.8-0.7-0.8-0.20.70.50.40.70.5
Pavlov. Cond. response bias0.60.84.8-2.2-0.5-0.9-0.7-0.8-0.30.60.40.30.60.4
Pavlov. Cond. lever latency1.92.63.10.11.71.71.71.71.81.71.71.71.61.6
Pavlov. Cond. magazine entry latency0.70.81.3-0.8-1.1-1.1-1.1-1.1-1.0-0.5-0.6-0.8-0.9-0.9
Pavlov. Cond. change in total contacts0.71.21.7-0.8-1.3-1.3-1.3-1.3-1.2-0.9-0.8-1.0-0.9-0.8
Pavlov. Cond. index score2.02.73.3-0.2-1.7-1.7-1.7-1.7-1.8-1.7-1.8-1.8-1.7-1.6
Pavlov. Cond. latency score2.43.23.9-0.1-1.9-1.8-1.8-1.8-2.0-1.9-1.9-2.0-1.9-1.7
Pavlov. Cond. lever contacts1.01.41.8-0.3-1.3-1.3-1.3-1.3-1.3-1.1-1.2-1.2-1.1-1.3
Pavlov. Cond. magazine entry number0.70.91.20.61.11.11.11.11.00.80.90.91.00.7
Pavlov. Cond. intertrial magazine entries0.71.11.80.91.31.31.31.21.20.80.60.90.90.7
Pavlov. Cond. lever-magazine prob. diff.2.02.73.3-0.2-1.7-1.7-1.7-1.7-1.8-1.7-1.7-1.8-1.7-1.5
Pavlov. Cond. response bias1.31.82.4-0.7-1.5-1.6-1.5-1.6-1.4-1.1-1.2-1.3-1.2-1.3
Time in closed arm before self-admin0.40.52.7-1.60.2-0.00.10.00.51.10.70.80.70.4
Time in closed arm after self-admin0.20.20.5-0.7-0.6-0.6-0.6-0.6-0.5-0.20.1-0.2-0.2-0.6
Time in open arm before self-admin1.92.04.00.1-1.6-1.3-1.4-1.3-1.4-1.4-1.1-1.4-1.8-2.0
Time in open arm after self-admin0.91.02.91.2-0.5-0.4-0.5-0.5-0.8-1.2-1.7-1.2-1.2-1.0
Bone: periosteal estimation0.40.94.92.20.71.10.91.00.4-0.7-0.6-0.2-0.9-0.2
Bone: periosteal perimeter0.30.52.31.50.60.80.70.70.3-0.5-0.4-0.2-0.70.1
Bone: post-yield work0.91.32.00.31.21.31.41.31.41.41.11.30.60.5
Progressive ratio test 1 active lever presses0.40.51.21.11.00.80.80.80.5-0.10.10.20.60.9
Progressive ratio test 1 breakpoint0.50.61.41.21.10.90.90.90.6-0.10.10.20.61.0
Progressive ratio test 1 inactive lever presses0.71.05.92.40.61.00.70.90.3-1.2-0.9-0.4-0.4-0.2
Progressive ratio test 2 active lever presses0.20.20.50.70.70.60.60.60.4-0.00.00.10.20.7
Progressive ratio test 2 breakpoint0.30.30.60.80.80.70.70.70.4-0.00.10.20.20.8
Progressive ratio test 2 inactive lever presses0.71.15.62.41.11.21.01.00.6-0.6-0.8-0.1-0.1-0.1
Incentive Sensitization - Responses0.10.10.30.20.20.40.40.40.30.20.10.2-0.6-0.2
Incentive Sensitization - Breakpoint0.10.10.40.20.20.40.40.40.30.20.10.2-0.6-0.2
Sum of active levers in priming session hrs 5-63.12.96.1-1.01.51.21.31.21.62.11.81.82.12.5
Progressive ratio0.30.41.31.10.30.10.10.0-0.3-0.8-1.1-0.7-0.40.6
Food seeking constrained by brief footshock0.10.10.6-0.1-0.5-0.3-0.3-0.3-0.4-0.2-0.1-0.3-0.8-0.4
Seeking ratio, punishment vs. effort0.20.30.9-1.0-0.7-0.5-0.5-0.4-0.20.30.60.2-0.0-0.9
Retroperitoneal fat weight0.31.22.40.91.51.31.31.31.20.70.40.81.11.0
Reaction time number correct0.10.30.40.40.40.50.50.50.60.40.50.60.5-0.6
Reaction time mean minus median0.51.22.1-0.4-1.1-1.3-1.2-1.3-1.2-1.0-1.4-1.2-0.9-0.7
Reaction time mean minus median AUC0.10.30.7-0.2-0.5-0.6-0.6-0.7-0.6-0.5-0.9-0.6-0.5-0.5
Reaction time num false alarms0.91.22.0-0.9-1.2-1.4-1.3-1.4-1.2-0.7-1.0-1.0-0.7-0.9
Reaction time num false alarms AUC0.71.11.7-0.7-1.2-1.3-1.3-1.3-1.1-0.7-0.9-0.9-0.8-1.0
Reaction time trials correct on left0.10.30.40.40.40.50.50.50.60.40.50.60.5-0.6
Reaction time trials on left0.10.20.40.40.40.50.50.50.60.40.50.60.5-0.7
Reaction time mean0.30.40.6-0.5-0.7-0.8-0.7-0.8-0.7-0.5-0.6-0.6-0.6-0.5
Reaction time mean AUC0.60.91.3-0.6-1.1-1.1-1.1-1.1-1.1-0.8-1.0-1.0-1.0-0.7
Median of all reaction times0.10.20.2-0.4-0.5-0.5-0.4-0.5-0.4-0.3-0.3-0.4-0.5-0.3
Reaction time omissions0.00.10.10.40.30.30.30.20.20.1-0.20.10.1-0.0
Reaction time false alarm rate0.71.01.6-0.8-1.1-1.3-1.2-1.3-1.2-0.7-1.0-1.0-0.8-0.5
Reaction time premature initiation rate0.30.51.9-1.4-0.6-0.6-0.5-0.6-0.10.70.60.30.1-1.0
Reaction time premature initiations0.20.41.5-1.0-0.4-0.3-0.2-0.20.10.80.90.60.3-1.2
Std. dev. reaction times0.91.72.5-1.0-1.5-1.6-1.5-1.6-1.4-0.9-1.2-1.2-1.0-1.0
Reaction time trials completed0.10.20.40.40.40.50.50.50.60.40.50.60.5-0.7
Reaction time trials AUC0.10.20.40.30.40.40.40.50.50.40.50.50.4-0.6
Run reversals in cocaine runway, females0.20.20.8-0.2-0.5-0.1-0.2-0.1-0.2-0.3-0.4-0.2-0.9-0.5
Run reversals in cocaine runway, males0.70.73.92.00.60.50.40.4-0.1-0.9-1.2-0.7-0.2-0.1
Latency to leave start box in cocaine runway0.10.10.4-0.3-0.3-0.2-0.1-0.1-0.10.20.20.0-0.4-0.7
Latency to leave start box in cocaine runway, F0.20.30.9-0.80.00.20.30.20.41.00.80.6-0.1-0.4
Latency to leave start box in cocaine runway, M0.20.10.91.00.30.20.10.1-0.1-0.5-0.4-0.30.10.1
Std. dev. time between licks in bursts0.60.91.60.71.21.00.91.00.90.60.70.71.31.2
Total sessions with >9 infusions0.91.13.71.91.21.31.31.20.8-0.1-0.30.2-0.41.0
Short access day 1 total inactive lever presses0.40.62.41.60.30.60.50.50.3-0.4-0.7-0.2-1.1-1.0
Short access day 10 total inactive lever presses0.61.43.21.3-1.0-0.4-0.6-0.5-1.0-1.5-1.3-1.3-1.8-1.3
Short access day 1 total infusions0.91.26.42.50.80.90.70.80.1-1.2-1.4-0.7-0.70.7
Short access day 10 total infusions0.50.62.91.70.60.70.70.60.2-0.7-0.7-0.3-0.60.3
Short access total infusions1.21.57.62.81.21.31.21.20.5-0.8-1.0-0.3-0.60.6
Short access day 1 locomotion0.60.72.41.6-0.1-0.0-0.2-0.1-0.5-1.3-1.3-1.0-0.8-0.2
Short access day 10 total locomotion0.51.03.31.8-0.20.20.00.1-0.4-1.3-1.3-1.0-1.5-0.7
Short access total locomotion1.01.23.11.5-0.6-0.2-0.3-0.2-0.8-1.6-1.2-1.2-1.8-1.0
One hour access (0.3 mA shock)1.41.63.81.91.71.61.51.51.10.20.00.50.81.5
Compulsive drug intake0.50.61.8-0.60.60.40.60.50.81.31.11.00.80.3
One hour access (shock baseline)0.40.62.51.60.90.90.80.90.4-0.4-0.4-0.10.40.9
Social response proportion2.32.75.6-2.00.90.80.90.91.52.42.12.02.01.3
Social responses2.32.94.60.72.11.92.01.92.01.81.21.71.61.5
Social time1.82.53.40.31.81.71.71.71.81.61.31.71.71.5
Soleus weight4.112.113.90.03.73.53.63.63.73.53.73.73.73.7
Bone: stiffness1.93.15.00.71.92.22.22.22.21.71.61.90.81.0
Tibialis anterior weight3.210.916.72.24.13.93.93.93.52.52.32.93.13.4
Time to tail flick, vehicle, before self-admin1.21.22.9-0.60.81.01.11.01.21.71.61.40.60.4
Time to tail flick, vehicle, after self-admin0.10.20.30.10.50.50.50.50.50.40.30.50.30.2
Time to tail flick, test, before self-admin1.01.06.0-2.4-0.9-1.0-0.9-0.9-0.30.80.80.40.6-0.4
Time to tail flick, test, after self-admin0.30.31.1-1.1-0.6-0.8-0.7-0.7-0.40.10.2-0.10.3-0.1
Delta time to tail flick, vehicle, before/after SA0.80.82.51.6-0.2-0.0-0.2-0.1-0.5-1.4-1.4-1.0-0.7-0.5
Delta time to tail flick, test, before/after SA0.40.42.61.60.30.40.20.3-0.1-0.8-0.7-0.5-0.40.2
Tibia length0.61.64.1-2.00.40.40.50.51.01.71.91.61.31.1
Ambulatory time before self-admin0.30.51.30.9-0.2-0.5-0.5-0.5-0.9-1.1-0.9-1.1-0.10.5
Ambulatory time after self-admin1.31.64.01.61.61.51.41.51.00.20.20.50.82.0
Bone: tissue strength0.60.61.80.7-0.6-0.4-0.4-0.4-0.6-0.8-0.9-0.8-1.3-1.2
Total heroin consumption3.44.07.0-0.51.92.02.12.02.32.62.32.41.31.5
Bone: trabecular number0.91.52.8-1.30.90.70.80.81.21.71.51.51.41.0
Bone: trabecular spacing0.60.82.71.0-0.7-0.2-0.3-0.3-0.6-1.0-0.9-0.8-1.6-1.4
Bone: trabecular thickness0.30.40.7-0.20.60.60.70.70.80.80.80.80.60.3
Bone: trabecular tissue density2.02.94.2-0.8-2.0-1.9-1.9-1.9-1.9-1.6-1.4-1.6-1.8-1.6
Water consumed over 24 hours1.01.45.5-2.3-1.5-1.4-1.3-1.2-0.70.40.70.1-0.2-1.1
Number of responses in last shaping day1.21.33.61.1-0.8-0.6-0.8-0.7-1.0-1.7-1.9-1.3-1.0-0.8