Hub : Genes

Tef

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC mRNA stability Tef 0.15 0.09 2.6e-03 0.09 0.08 0.03 0.07 3.8e-03 6.5e-03 6.2e-02 8.6e-03
2 IL mRNA stability Tef 0.15 0.1 5.4e-03 0.04 0.02 -0.01 0.02 4.3e-02 9.7e-02 5.8e-01 1.1e-01
3 Liver mRNA stability Tef 0.06 0.03 1.2e-07 0.04 0.04 0.03 0.03 1.2e-05 8.8e-05 3.5e-04 3.3e-04
4 NAcc mRNA stability Tef 0.02 0.02 4.9e-03 0.01 0 0.01 0.01 3.1e-03 5.0e-02 3.3e-02 2.2e-02
5 NAcc alternative TSS XM_006242068.5 0.01 0.01 9.6e-03 0.01 0.01 0 0 2.2e-02 2.5e-02 3.3e-01 7.0e-02
6 IC mRNA stability Tef 0.08 0.05 4.4e-03 0.03 0.04 0.02 0.03 2.6e-02 7.7e-03 3.4e-02 2.5e-02
7 Brain mRNA stability Tef 0.03 0.02 3.0e-03 0.02 0.02 0.02 0.02 1.0e-02 1.1e-02 1.1e-02 6.8e-03
8 PL gene expression Tef 0.15 0.08 1.8e-04 0.05 0.04 0.03 0.04 9.0e-06 3.2e-05 2.2e-04 5.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.20.40.90.50.60.70.90.40.4-0.60.9
Area under the delay curve0.30.30.90.90.50.20.30.80.5-0.5-0.1
BMI with tail1.13.65.6-2.4-1.7-1.9-1.9-1.9-2.11.81.4
BMI without tail0.00.20.6-0.4-0.2-0.20.0-0.4-0.1-0.40.8
Body weight1.15.07.1-2.7-2.1-2.2-2.2-2.4-2.12.41.6
Weight adjusted by age0.20.20.80.6-0.40.10.10.40.9-0.70.3
Bone surface0.50.92.31.10.40.70.81.31.5-0.90.7
Bone volume0.10.20.40.40.10.20.40.60.6-0.40.6
Breakpoint value in progressive ratio session0.10.10.6-0.20.1-0.0-0.0-0.4-0.40.20.8
Number of licking bursts0.61.12.01.40.90.90.91.31.3-0.80.4
Context. condit. distance diff. score6.37.610.2-3.0-3.2-3.2-3.1-2.8-2.42.6-0.9
Locomotion velocity, session 10.50.62.00.9-0.00.10.21.21.4-0.6-0.1
Locomotion distance, session 13.84.98.02.71.91.92.02.82.7-2.0-0.9
Locomotion velocity, session 20.20.20.4-0.3-0.6-0.6-0.2-0.30.00.20.6
Locomotion distance, session 22.83.86.12.51.92.02.12.31.9-1.60.9
Locomotion velocity, session 30.20.21.2-0.1-0.3-0.4-0.3-0.00.40.1-1.1
Locomotion distance, session 32.32.54.01.71.31.31.21.91.8-1.2-2.0
Stereotopy head waving bouts, day 30.91.01.7-1.0-1.2-1.1-0.8-1.1-0.60.81.3
Stereotopy head waving duration, day 33.74.46.3-2.3-2.5-2.4-2.0-2.4-1.51.71.8
Locomotion velocity, session 70.10.10.2-0.3-0.1-0.4-0.5-0.2-0.10.3-0.3
Locomotion distance, session 70.10.10.50.30.70.1-0.10.3-0.20.4-0.3
Stereotopy head waving bouts, day 71.41.53.4-1.5-1.8-1.4-1.3-1.5-0.20.8-0.2
Stereotopy head waving duration, day 71.61.93.7-1.9-1.7-1.4-1.2-1.9-0.80.8-0.5
Locomotion velocity, session 81.82.15.1-1.0-2.3-1.8-1.7-1.0-0.81.41.1
Locomotion distance, session 80.71.02.0-0.9-1.4-1.4-1.1-0.9-0.70.8-0.7
Degree of sensitization distance4.04.27.1-2.3-1.5-1.9-1.8-2.3-2.72.11.5
Degree of sensitization stereotypy1.01.12.4-1.2-1.5-1.2-1.1-1.2-0.20.7-0.4
Conditioned locomotion0.60.71.2-0.8-1.1-1.1-0.7-0.8-0.60.5-0.6
Cocaine response after cond. corrected0.10.10.3-0.3-0.2-0.2-0.4-0.5-0.10.30.1
Cocaine response after cond. not corrected0.10.10.3-0.3-0.3-0.3-0.3-0.6-0.00.00.0
Cocaine response before conditioning0.10.10.60.30.0-0.00.50.10.3-0.7-0.3
Saline control response0.40.52.6-0.0-0.5-0.80.10.20.2-0.6-1.6
Bone: connectivity density0.10.21.00.20.30.40.50.10.3-0.11.0
Bone: cortical apparent density1.01.42.21.31.41.11.21.51.1-1.2-0.3
Bone: cortical area1.52.33.1-1.5-1.8-1.7-1.7-1.2-1.21.31.6
Bone: cortical porosity0.60.71.8-1.1-0.6-0.7-0.5-1.3-0.90.60.1
Bone: cortical porosity1.81.93.6-1.7-1.4-1.4-1.2-1.9-1.21.20.5
Bone: cortical thickness0.60.93.3-0.6-0.6-0.8-0.8-0.4-1.10.91.8
Bone: cortical thickness0.70.93.5-0.3-0.8-0.8-0.8-0.3-0.90.91.9
Bone: cortical tissue density1.01.32.11.31.31.11.21.41.1-1.1-0.3
Condit. Reinf. active minus inactive responses0.20.20.50.60.40.20.30.70.3-0.30.6
Condit. Reinf. active-inactive response ratio0.20.20.4-0.4-0.5-0.6-0.7-0.2-0.30.3-0.0
Condit. Reinf. active responses1.11.32.01.31.21.01.31.40.8-1.4-0.1
Condit. Reinf. inactive responses2.22.74.01.71.81.62.01.71.1-1.9-1.0
Incentive salience index mean0.40.51.20.90.70.50.71.10.4-0.60.6
Condit. Reinf. lever presses0.70.91.71.10.90.81.21.30.7-1.10.2
Condit. Reinf. active minus inactive responses0.20.31.30.50.0-0.0-0.30.90.00.21.1
Condit. Reinf. active-inactive response ratio0.50.53.5-0.00.0-0.0-0.30.1-0.40.61.9
Condit. Reinf. active responses0.40.51.0-0.1-1.0-0.8-1.00.3-0.30.60.9
Condit. Reinf. inactive responses0.60.82.1-0.4-1.4-1.3-1.3-0.1-0.30.6-0.1
Condit. Reinf. lever presses0.30.40.80.70.50.60.50.90.4-0.60.5
Condit. Reinf. lever reinforcers received0.20.30.8-0.1-0.7-0.5-0.70.4-0.20.40.9
Conditioned reinforcement - actives0.30.61.4-0.8-0.5-0.8-1.2-0.6-0.60.50.6
Conditioned reinforcement - inactives0.30.41.30.4-0.1-0.3-0.51.1-0.50.21.1
Conditioned locomotion2.02.53.4-1.8-1.2-1.6-1.7-1.4-1.71.41.8
Patch foraging indifference point 0 sec0.30.61.10.60.80.70.70.60.4-1.00.9
Patch foraging indifference point AUC0.81.22.81.70.90.80.71.51.4-0.8-0.4
Delay disc. indifference point, 0s delay1.11.32.0-1.4-1.1-1.3-1.1-1.0-1.40.90.2
Delay disc. indifference point, 16s delay1.21.32.51.61.21.21.01.41.2-0.8-0.3
Delay disc. indifference point, 2s delay0.00.10.20.2-0.2-0.4-0.30.2-0.1-0.10.1
Delay disc. indifference point, 24s delay0.70.81.91.40.80.50.41.21.4-0.40.4
Delay disc. indifference point, 4s delay0.10.10.30.5-0.3-0.2-0.00.4-0.0-0.20.5
Delay disc. indifference point, 8s delay0.60.81.51.21.10.70.91.00.8-0.7-0.4
Indifference point function ln k0.91.62.9-1.7-1.3-1.2-1.0-1.6-1.21.10.2
Indifference point function log k0.91.62.9-1.7-1.3-1.2-1.0-1.6-1.21.10.2
Patch foraging total patch changes 0 sec0.40.71.40.70.90.90.90.70.5-1.20.7
Patch foraging total patch changes 12 sec0.10.10.20.50.20.10.10.50.3-0.30.3
Patch foraging total patch changes 18 sec0.20.30.60.70.20.30.20.70.2-0.60.8
Patch foraging total patch changes 24 sec0.40.71.11.00.80.70.70.90.9-1.0-0.4
Patch foraging total patch changes 6 sec0.60.92.21.20.30.50.61.20.9-0.91.5
Patch foraging time to switch 0 sec0.10.20.5-0.70.30.10.2-0.6-0.4-0.1-0.5
Patch foraging water rate 0 sec0.10.31.10.5-0.20.30.30.50.3-0.31.0
Patch foraging water rate 12 sec0.30.71.10.60.71.00.81.00.8-1.0-0.4
Patch foraging water rate 18 sec1.21.92.91.41.01.61.51.71.6-1.20.5
Patch foraging water rate 24 sec0.10.10.5-0.4-0.50.0-0.1-0.1-0.20.30.7
Patch foraging water rate 6 sec1.11.72.91.40.91.21.31.51.7-1.2-0.9
Seeking ratio, delayed vs. immediate footshock2.73.36.01.62.42.12.02.21.3-1.60.2
Distance traveled before self-admin0.10.10.50.50.40.10.20.1-0.7-0.20.2
Distance traveled after self-admin0.40.53.00.40.5-0.00.00.40.1-0.41.7
Extensor digitorum longus weight0.10.51.10.30.90.70.90.70.5-1.0-0.4
Bone: elastic displacement0.00.10.3-0.0-0.30.00.00.20.5-0.10.2
Bone: elastic work2.22.94.1-1.9-2.0-1.7-1.7-1.7-1.41.61.4
Bone: endosteal estimation0.30.72.2-1.1-1.5-1.1-0.7-0.80.10.3-0.3
Bone: endosteal perimeter1.02.24.3-1.9-2.1-1.7-1.7-1.5-0.61.1-0.1
Epididymis fat weight2.58.512.5-3.5-2.7-3.1-2.9-3.5-3.32.80.2
Delta time in closed arm before/after self-admin0.40.40.80.3-0.6-0.6-0.7-0.6-0.60.60.9
Delta time in open arm before/after self-admin0.60.62.2-0.2-0.10.40.20.80.9-0.8-1.5
Diff in mean of infusions in LGA sessions0.30.32.00.5-0.4-0.3-0.3-0.2-0.00.41.4
Delay discount exponential model param0.40.41.1-1.1-0.5-0.2-0.4-0.9-0.60.60.2
Extinction: sum of active levers before priming1.11.21.9-1.0-1.2-1.1-1.0-1.2-1.01.40.9
Active lever presses in extinction session 60.30.30.6-0.7-0.8-0.6-0.4-0.5-0.50.20.5
Bone: final force1.62.53.6-1.4-1.6-1.7-1.6-1.2-1.51.71.9
Bone: final moment1.72.74.4-1.4-1.7-1.7-1.7-1.2-1.41.82.1
Food consumed during 24 hour testing period1.72.43.6-1.4-1.6-1.5-1.5-1.3-1.51.61.9
Glucose0.10.20.6-0.20.1-0.10.10.0-0.6-0.50.8
Heart weight7.111.017.0-3.5-4.1-4.0-3.7-3.0-3.12.52.1
Delay discount hyperbolic model param0.20.30.9-0.9-0.3-0.1-0.3-0.8-0.50.50.2
Intermittent access intake day 1-15 change0.10.30.70.30.80.60.80.00.1-0.5-0.2
Intermittent access intake escalation0.20.51.10.71.00.80.90.30.4-0.7-0.4
Intermittent access intake escalation 20.40.51.40.41.20.80.90.20.3-0.6-0.6
Intermitt. access day 1 inactive lever presses0.41.42.9-1.2-1.1-1.0-1.0-0.8-1.70.91.6
Intermitt. access day 15 inactive lever presses0.30.51.50.2-0.6-0.7-0.50.5-1.20.41.2
Intermitt. access escalation Index0.30.41.51.20.40.40.60.80.5-0.60.4
Intermittent access day 1 total infusions0.50.71.5-0.3-1.0-1.1-1.2-0.5-1.00.60.8
Intermittent access day 15 total infusions0.10.10.40.50.40.10.20.20.1-0.7-0.4
Intermittent access terminal intake (last 3 days)0.10.10.30.20.5-0.00.1-0.1-0.1-0.4-0.5
Intermittent access total infusions0.10.20.4-0.1-0.2-0.5-0.6-0.4-0.60.20.3
Intermittent access day 1 locomotion0.30.40.9-0.5-0.7-0.5-0.5-0.3-0.90.30.8
Intermittent access day 15 total locomotion0.20.30.6-0.7-0.3-0.2-0.4-0.6-0.70.60.5
Intermittent access total locomotion0.40.51.0-0.8-0.3-0.4-0.5-0.8-1.00.70.6
Intermittent access standard deviation0.71.43.6-1.4-0.3-0.9-0.7-1.8-1.90.70.6
Left kidney weight9.845.565.1-7.0-8.1-7.9-7.5-6.3-6.06.73.3
Right kidney weight12.054.470.2-7.8-8.4-8.3-7.8-7.1-7.17.54.0
Cocaine induced anxiety1.01.42.4-1.2-0.2-0.5-0.9-1.3-1.51.61.4
Post-drug Anxiety0.10.10.40.10.70.5-0.0-0.3-0.00.20.3
Baseline Anxiety2.42.84.21.91.21.31.31.82.0-1.8-1.9
Tail length0.62.23.81.51.21.51.60.81.9-2.0-1.0
Length with tail0.10.40.8-0.7-0.9-0.7-0.7-0.8-0.20.70.0
Length without tail2.06.59.3-2.9-2.5-2.4-2.7-2.5-2.53.11.5
Times rat made contact with spout0.50.61.2-0.2-0.9-1.0-0.9-0.1-0.50.91.1
Lifetime Intake0.70.91.6-0.5-0.7-1.1-1.2-0.6-1.20.81.1
Liver weight, left0.71.23.0-1.0-1.1-1.2-1.4-0.7-0.30.6-1.7
Liver weight, right1.83.14.6-2.1-1.7-2.0-1.9-1.9-1.41.3-1.6
Locomotor activity1.62.64.3-2.1-1.6-1.5-1.7-2.0-1.21.70.3
Locomotor testing distance0.10.10.50.10.70.40.3-0.10.2-0.3-0.3
Locomotor testing rearing1.02.12.9-1.5-1.4-1.7-1.6-1.7-1.31.3-0.1
Locomotion in novel chamber0.91.13.60.10.30.30.21.01.3-1.5-1.9
Locomotion in novel chamber post-restriction0.71.11.90.81.21.11.10.71.0-1.0-1.4
Fecal boli incidents, locomotor time 10.20.30.40.60.30.60.60.50.6-0.30.5
Change in fecal boli incidents, locomotor task0.20.20.6-0.1-0.6-0.5-0.6-0.30.40.80.1
Time >=10cm from walls, locomotor time 10.30.30.7-0.5-0.2-0.3-0.4-0.6-0.40.60.8
Bouts of movement, locomotor time 10.30.41.1-0.7-0.1-0.4-0.5-0.7-0.81.00.0
Total resting periods, locomotor time 10.30.30.9-0.50.1-0.2-0.3-0.5-0.91.00.4
Rest time, locomotor task time 11.01.32.6-1.1-0.5-1.0-0.9-0.9-1.61.61.1
Distance moved, locomotor task time 10.30.41.0-0.5-1.0-0.7-0.6-0.8-0.2-0.1-0.6
Vertical activity count, locomotor time 10.00.00.30.00.00.10.2-0.20.2-0.5-0.2
Time >=10cm from walls, locomotor time 20.20.20.80.30.50.30.40.40.5-0.40.9
Bouts of movement, locomotor time 20.30.51.2-0.8-0.2-0.7-0.6-0.0-1.10.90.5
Total resting periods, locomotor time 20.20.41.0-0.6-0.1-0.6-0.5-0.0-1.00.90.7
Rest time, locomotor task time 20.00.10.10.40.40.20.20.20.10.20.2
Distance moved, locomotor task time 20.60.71.3-1.0-1.0-1.2-1.0-1.0-0.70.3-0.3
Vertical activity count, locomotor time 20.10.20.5-0.5-0.4-0.5-0.3-0.7-0.2-0.00.1
Light reinforcement 10.10.20.50.0-0.2-0.3-0.30.20.7-0.70.3
Light reinforcement 20.60.91.6-1.2-0.4-1.2-1.0-1.3-1.10.8-0.1
Bone: marrow area0.40.82.5-1.1-1.6-1.2-0.8-0.90.00.4-0.2
Bone: maximum diameter3.46.39.4-2.7-3.1-2.9-2.8-2.3-1.82.32.0
Bone: maximum force2.44.35.9-1.8-2.3-2.2-2.2-1.7-1.82.12.4
Bone: maximum moment2.74.76.6-1.9-2.4-2.3-2.2-1.7-1.82.22.6
Mean time between licks in bursts0.20.50.90.60.90.80.80.50.4-0.90.1
Mean num. licks in bursts1.42.23.0-1.6-1.7-1.7-1.6-1.4-1.51.6-0.0
Cd content in liver0.80.91.8-0.5-1.3-1.2-1.2-0.3-0.41.10.7
Co content in liver0.40.53.30.3-0.1-0.1-0.20.5-0.10.41.8
Cu content in liver6.17.29.12.92.73.02.92.92.7-3.0-0.2
Fe content in liver0.81.01.8-1.2-1.1-0.9-0.7-1.3-0.60.61.1
K content in liver1.21.11.91.40.61.01.31.21.1-1.10.1
Mg content in liver0.90.91.51.20.71.11.11.20.7-0.80.7
Mn content in liver0.20.20.50.4-0.7-0.10.00.30.4-0.2-0.6
Na content in liver1.71.92.91.41.41.71.51.21.3-1.6-0.5
Rb content in liver0.30.42.30.2-0.5-0.3-0.40.4-0.10.51.5
Se content in liver0.60.70.90.70.80.90.90.51.0-0.9-0.8
Sr content in liver1.91.72.51.51.61.41.21.20.9-1.5-0.7
Zn content in liver0.20.20.80.7-0.10.20.20.90.7-0.40.0
Bone: minimum diameter0.30.61.0-1.0-1.0-0.8-1.0-0.8-0.30.40.3
Time in familiar zone, hab. session 10.10.10.20.3-0.2-0.1-0.40.50.50.20.3
Time in novel zone, hab. session 10.80.82.4-1.3-0.9-0.8-0.4-1.5-0.90.4-0.1
Total zone transitions, hab. session 15.17.111.43.12.32.42.53.43.1-2.4-1.9
Total locomotion distance, hab. session 13.34.67.52.31.41.71.82.32.7-2.2-2.5
Locomotion velocity, hab. session 13.54.97.42.41.61.82.02.52.7-2.3-2.1
Time in familiar zone, hab. session 20.40.42.9-0.10.30.0-0.30.20.2-0.4-1.7
Time in novel zone, hab. session 20.30.31.80.0-0.5-0.20.1-0.4-0.20.31.4
Total zone transitions, hab. session 21.72.15.12.00.70.91.42.31.7-1.20.3
Total locomotion distance, hab. session 21.01.32.21.50.70.91.21.51.3-1.20.2
Locomotion velocity, hab. session 21.72.33.71.91.11.31.61.91.7-1.60.1
Novel to familiar place preference ratio1.82.03.6-1.7-1.9-1.4-1.4-1.7-0.91.40.3
Novelty place preference2.42.64.4-1.9-2.1-1.6-1.7-1.9-1.01.60.2
Time in novel zone, NPP test3.13.35.8-2.1-2.4-1.9-1.9-2.1-1.21.90.3
Total zone transitions, NPP test4.56.410.83.21.92.12.43.33.1-2.3-1.3
Total locomotion distance, NPP test2.02.84.42.11.21.51.82.02.0-1.5-0.6
Locomotion velocity, NPP test2.94.15.72.41.81.92.22.32.3-2.0-0.9
Intraocular pressure0.20.30.8-0.4-0.5-0.4-0.9-0.9-0.30.6-0.5
Delta distance traveled before/after self-admin0.40.41.3-0.3-0.7-0.7-0.8-0.10.50.21.1
Delta ambulatory time before/after self-admin0.50.62.0-0.2-1.0-0.8-0.9-0.00.50.31.4
Parametrial fat weight0.10.32.0-0.20.2-0.10.1-0.60.0-0.3-1.4
Pavlov. Cond. lever latency0.30.40.9-0.7-0.8-0.6-1.0-0.5-0.40.70.1
Pavlov. Cond. magazine entry latency0.40.51.00.91.00.70.70.80.3-0.40.4
Pavlov. Cond. change in total contacts1.01.12.01.41.00.71.01.30.6-0.81.2
Pavlov. Cond. index score0.20.20.50.60.70.30.60.5-0.1-0.10.5
Pavlov. Cond. latency score0.10.20.40.50.60.30.60.4-0.1-0.20.5
Pavlov. Cond. lever contacts1.11.32.31.31.51.21.51.10.7-1.2-0.3
Pavlov. Cond. magazine entry number0.40.51.1-1.0-1.1-0.6-0.7-0.8-0.20.3-0.3
Pavlov. Cond. intertrial magazine entries1.01.21.51.21.21.21.21.21.0-1.10.5
Pavlov. Cond. lever-magazine prob. diff.0.30.40.80.80.90.50.70.70.1-0.30.4
Pavlov. Cond. response bias0.60.71.41.11.20.81.00.90.3-0.60.2
Pavlov. Cond. lever latency0.50.71.1-0.7-0.7-0.9-1.1-0.9-0.50.9-0.9
Pavlov. Cond. magazine entry latency2.53.05.31.72.32.32.11.61.0-1.21.2
Pavlov. Cond. change in total contacts0.60.96.00.40.40.60.60.6-0.1-0.12.4
Pavlov. Cond. index score1.31.72.61.31.51.61.61.40.7-1.01.0
Pavlov. Cond. latency score1.82.43.51.61.81.91.81.70.9-1.31.1
Pavlov. Cond. lever contacts0.71.01.50.80.91.11.21.10.7-1.10.8
Pavlov. Cond. magazine entry number1.51.83.5-1.3-1.8-1.9-1.6-1.3-0.80.9-0.9
Pavlov. Cond. intertrial magazine entries2.43.65.6-1.6-2.2-2.4-2.3-1.4-2.01.91.2
Pavlov. Cond. lever-magazine prob. diff.1.41.93.11.31.61.81.71.40.8-1.20.9
Pavlov. Cond. response bias0.81.11.60.91.01.31.21.10.6-0.91.2
Time in closed arm before self-admin4.35.59.22.03.02.62.91.52.0-2.9-0.6
Time in closed arm after self-admin0.10.10.30.20.4-0.10.2-0.6-0.1-0.4-0.1
Time in open arm before self-admin0.10.10.30.2-0.10.1-0.0-0.20.10.3-0.6
Time in open arm after self-admin0.50.52.3-0.2-0.10.60.30.51.0-0.4-1.5
Bone: periosteal estimation0.91.93.8-1.6-2.0-1.7-1.4-1.3-0.61.00.7
Bone: periosteal perimeter2.94.97.6-2.7-2.8-2.5-2.6-2.2-1.51.90.7
Bone: post-yield work0.50.73.1-0.1-0.8-0.7-0.7-0.3-0.40.81.8
Progressive ratio test 1 active lever presses0.20.30.60.2-0.3-0.5-0.5-0.4-0.80.20.8
Progressive ratio test 1 breakpoint0.10.20.40.3-0.1-0.4-0.4-0.3-0.60.10.7
Progressive ratio test 1 inactive lever presses0.81.23.9-0.8-0.7-1.2-1.2-0.2-2.00.71.2
Progressive ratio test 2 active lever presses0.10.20.50.4-0.0-0.3-0.50.1-0.40.10.7
Progressive ratio test 2 breakpoint0.10.10.40.50.0-0.2-0.40.1-0.30.10.6
Progressive ratio test 2 inactive lever presses0.20.40.91.00.60.50.40.7-0.2-0.8-0.4
Incentive Sensitization - Responses0.10.20.70.80.20.2-0.10.80.2-0.3-0.0
Incentive Sensitization - Breakpoint0.10.10.40.60.10.0-0.30.70.0-0.10.1
Sum of active levers in priming session hrs 5-60.10.10.5-0.2-0.7-0.00.1-0.3-0.20.30.1
Progressive ratio0.00.00.2-0.10.30.20.40.0-0.20.1-0.1
Food seeking constrained by brief footshock1.01.32.7-1.1-0.6-1.3-1.6-0.7-1.11.30.9
Seeking ratio, punishment vs. effort0.40.61.3-0.7-0.6-1.0-1.1-0.6-0.60.70.8
Retroperitoneal fat weight4.017.122.5-4.7-4.1-4.4-4.3-4.7-4.14.31.4
Reaction time number correct1.22.33.11.41.61.61.31.41.8-1.4-1.6
Reaction time mean minus median0.10.30.7-0.7-0.8-0.5-0.2-0.5-0.40.1-0.8
Reaction time mean minus median AUC0.51.32.1-1.4-1.3-1.0-0.8-1.4-1.20.8-0.9
Reaction time num false alarms0.10.20.6-0.00.1-0.1-0.10.10.5-0.8-0.7
Reaction time num false alarms AUC0.30.41.10.30.20.10.10.40.8-1.0-1.0
Reaction time trials correct on left1.22.33.11.41.61.61.31.41.8-1.4-1.6
Reaction time trials on left1.32.53.41.51.61.61.31.51.8-1.5-1.7
Reaction time mean0.10.10.3-0.10.10.50.5-0.5-0.2-0.3-0.2
Reaction time mean AUC0.10.10.2-0.00.20.50.4-0.5-0.1-0.2-0.2
Median of all reaction times0.20.20.80.20.50.90.7-0.30.1-0.50.0
Reaction time omissions0.30.51.40.60.10.40.40.70.8-0.9-1.2
Reaction time false alarm rate0.20.20.5-0.6-0.5-0.7-0.6-0.4-0.4-0.1-0.1
Reaction time premature initiation rate0.40.63.70.40.70.40.4-0.10.1-0.11.9
Reaction time premature initiations0.40.71.40.81.20.90.70.30.7-0.51.1
Std. dev. reaction times0.30.50.9-0.9-0.9-0.7-0.5-0.9-0.70.3-0.7
Reaction time trials completed1.32.53.41.51.61.61.31.51.8-1.5-1.7
Reaction time trials AUC1.01.92.71.31.41.41.11.21.6-1.3-1.5
Run reversals in cocaine runway, females0.70.71.20.90.80.50.71.11.1-0.9-0.4
Run reversals in cocaine runway, males0.40.41.00.1-1.0-0.7-0.8-0.50.10.5-0.7
Latency to leave start box in cocaine runway0.40.41.2-0.9-0.1-0.4-0.3-1.1-0.80.5-0.0
Latency to leave start box in cocaine runway, F0.10.10.2-0.00.50.40.50.00.2-0.3-0.1
Latency to leave start box in cocaine runway, M1.51.43.1-1.6-0.7-1.0-1.0-1.8-1.51.10.0
Std. dev. time between licks in bursts1.31.72.21.41.11.31.51.41.1-1.41.2
Total sessions with >9 infusions5.26.38.0-1.9-2.6-2.8-2.7-1.9-2.72.42.8
Short access day 1 total inactive lever presses1.62.15.7-1.1-1.7-1.6-1.4-0.2-1.31.02.4
Short access day 10 total inactive lever presses0.41.02.1-1.4-0.6-1.2-1.1-1.1-1.01.0-0.1
Short access day 1 total infusions1.92.54.1-1.1-1.8-2.0-1.9-0.5-1.71.11.8
Short access day 10 total infusions1.72.14.0-1.2-1.0-1.5-1.4-2.0-1.81.11.4
Short access total infusions3.13.96.3-1.2-2.0-2.2-2.2-1.3-2.31.72.5
Short access day 1 locomotion0.91.11.9-0.9-1.0-1.2-0.9-0.8-1.40.81.3
Short access day 10 total locomotion0.20.31.1-0.9-0.1-0.2-0.1-0.9-1.1-0.00.2
Short access total locomotion1.82.13.7-1.5-1.2-1.4-1.2-1.6-1.91.11.6
One hour access (0.3 mA shock)0.20.21.0-0.11.00.30.2-0.3-0.3-0.6-0.4
Compulsive drug intake0.40.51.30.90.10.50.21.11.0-0.20.6
One hour access (shock baseline)0.20.30.8-0.40.90.10.1-0.7-0.7-0.4-0.6
Social response proportion0.70.81.8-1.2-0.6-0.4-0.0-1.3-1.10.61.3
Social responses0.10.20.60.40.40.20.40.40.8-0.50.1
Social time1.41.92.81.51.51.51.71.61.1-1.3-0.4
Soleus weight0.30.82.71.1-0.20.20.31.60.7-0.31.2
Bone: stiffness1.62.73.5-1.6-1.7-1.7-1.6-1.6-1.51.51.9
Tibialis anterior weight0.62.03.41.41.91.61.51.80.9-1.40.1
Time to tail flick, vehicle, before self-admin0.10.10.8-0.0-0.9-0.20.0-0.10.2-0.10.2
Time to tail flick, vehicle, after self-admin1.41.83.01.21.01.21.01.61.7-1.5-1.4
Time to tail flick, test, before self-admin0.50.50.8-0.6-0.4-0.9-0.9-0.7-0.50.8-0.6
Time to tail flick, test, after self-admin0.40.40.70.80.60.50.30.40.6-0.8-0.7
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.10.40.1-0.20.3-0.1-0.1-0.1
Delta time to tail flick, test, before/after SA2.52.54.31.81.31.61.61.91.5-2.1-0.4
Tibia length0.61.62.3-0.9-1.4-1.3-1.5-0.9-0.71.51.4
Ambulatory time before self-admin0.10.20.70.80.20.10.20.5-0.2-0.5-0.4
Ambulatory time after self-admin1.31.52.31.51.00.90.91.51.4-1.40.8
Bone: tissue strength0.10.10.2-0.3-0.2-0.2-0.4-0.50.00.40.4
Total heroin consumption0.40.51.60.2-0.8-0.7-0.5-0.3-0.40.81.2
Bone: trabecular number0.00.00.10.00.20.30.20.10.3-0.2-0.2
Bone: trabecular spacing1.41.92.9-1.2-1.4-1.4-1.5-1.3-1.31.71.2
Bone: trabecular thickness0.20.20.60.20.40.50.80.40.0-0.7-0.5
Bone: trabecular tissue density1.42.14.01.31.71.72.01.40.9-1.60.4
Water consumed over 24 hours0.40.51.4-0.2-0.8-0.9-0.7-0.2-0.30.81.2
Number of responses in last shaping day0.40.51.50.50.50.10.80.3-0.8-0.51.2