Hub : Genes

Tcf19

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Tcf19 0.26 0.1 0.0e+00 0.16 0.21 0.2 0.21 1.7e-14 1.4e-19 1.9e-18 2.7e-19
2 Eye mRNA stability Tcf19 0.39 0.18 3.4e-03 0.08 0.1 0.09 0.12 2.7e-02 1.3e-02 1.6e-02 6.5e-03
3 BLA gene expression Tcf19 0.23 0.09 4.1e-11 0.17 0.18 0.12 0.17 1.7e-09 7.0e-10 6.0e-07 1.9e-09
4 OFC gene expression Tcf19 0.26 0.13 1.5e-04 0.16 0.14 0.12 0.14 1.5e-04 3.9e-04 9.2e-04 2.7e-04
5 IL gene expression Tcf19 0.36 0.14 1.3e-06 0.26 0.24 0.23 0.24 4.6e-07 1.4e-06 2.7e-06 1.9e-06
6 PL gene expression Tcf19 0.34 0.1 0.0e+00 0.21 0.32 0.32 0.3 7.4e-23 2.0e-35 1.3e-35 3.8e-33
7 Adipose gene expression Tcf19 0.09 0.05 7.3e-13 0.11 0.11 0.12 0.1 6.5e-12 5.0e-12 9.5e-13 2.5e-11
8 pVTA gene expression Tcf19 0.06 0.03 1.8e-04 0.02 0.04 0.02 0.02 5.1e-03 7.2e-04 7.5e-03 1.8e-02
9 IC gene expression Tcf19 0.37 0.12 3.0e-12 0.12 0.24 0.23 0.22 7.4e-06 2.0e-10 5.8e-10 1.2e-09
10 NAcc gene expression Tcf19 0.06 0.03 6.2e-07 0.02 0.04 0.03 0.02 4.0e-04 8.7e-07 4.5e-05 1.1e-04
11 Liver gene expression Tcf19 0.08 0.04 1.2e-06 0.05 0.03 0.04 0.04 4.9e-06 1.7e-04 1.0e-05 4.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.83.04.7-2.0-0.8-2.0-1.6-1.6-2.20.4-2.1-2.0-2.1-1.6
Area under the delay curve0.91.02.20.61.01.01.51.40.9-0.80.90.61.10.8
BMI with tail0.72.35.9-0.32.40.92.01.90.4-2.41.10.81.2-1.3
BMI without tail1.85.511.50.63.41.83.03.01.5-3.42.21.82.2-1.0
Body weight4.620.231.03.74.35.25.65.54.1-3.25.14.85.00.7
Weight adjusted by age2.74.17.02.10.62.41.91.72.3-1.02.62.62.61.1
Bone surface0.20.30.60.7-0.00.70.60.60.70.40.60.60.50.6
Bone volume0.00.10.2-0.20.40.00.30.3-0.1-0.3-0.0-0.1-0.1-0.4
Breakpoint value in progressive ratio session0.20.30.7-0.2-0.3-0.5-0.8-0.8-0.30.4-0.5-0.4-0.50.4
Number of licking bursts0.60.93.30.9-1.00.4-0.4-0.40.91.80.30.40.41.8
Context. condit. distance diff. score3.64.313.70.5-3.5-0.9-2.6-2.6-0.63.7-1.1-0.6-1.41.9
Locomotion velocity, session 10.20.20.90.3-0.9-0.1-0.4-0.4-0.10.8-0.2-0.1-0.20.5
Locomotion distance, session 10.81.11.9-1.40.0-1.2-0.8-0.8-1.30.2-1.2-1.4-1.1-1.0
Locomotion velocity, session 20.10.10.30.2-0.40.10.00.00.30.5-0.1-0.1-0.00.5
Locomotion distance, session 20.40.61.0-0.7-0.5-0.7-0.7-0.7-1.01.0-0.9-0.9-0.8-0.5
Locomotion velocity, session 30.30.31.2-0.70.7-0.50.10.1-0.4-1.1-0.4-0.5-0.3-0.8
Locomotion distance, session 31.51.72.6-1.2-0.8-1.4-1.4-1.4-1.40.8-1.6-1.5-1.6-0.7
Stereotopy head waving bouts, day 32.32.73.91.90.61.91.61.62.0-0.01.91.91.91.7
Stereotopy head waving duration, day 31.61.92.71.60.61.51.31.31.6-0.51.61.61.61.3
Locomotion velocity, session 73.94.35.9-1.5-2.3-2.0-2.4-2.4-2.12.1-2.3-2.0-2.4-0.7
Locomotion distance, session 74.15.17.4-2.0-1.9-2.4-2.4-2.4-2.51.8-2.7-2.6-2.7-1.1
Stereotopy head waving bouts, day 71.82.04.31.01.61.42.12.11.4-1.21.20.91.30.5
Stereotopy head waving duration, day 71.82.24.21.11.61.52.02.01.5-1.21.41.11.40.5
Locomotion velocity, session 82.53.08.22.3-1.61.50.10.11.82.61.21.51.12.9
Locomotion distance, session 82.33.312.80.1-2.9-0.8-2.1-2.1-0.93.6-1.2-0.8-1.31.2
Degree of sensitization distance0.50.51.70.7-1.20.2-0.4-0.40.41.30.20.30.21.2
Degree of sensitization stereotypy0.60.61.70.21.20.61.31.30.7-0.80.40.10.50.1
Conditioned locomotion1.01.11.71.20.31.31.01.01.20.11.31.31.20.9
Cocaine response after cond. corrected0.50.61.9-0.4-0.8-0.5-0.9-0.9-0.61.4-0.6-0.5-0.50.2
Cocaine response after cond. not corrected0.60.71.61.1-0.30.90.30.30.91.00.80.90.91.3
Cocaine response before conditioning5.36.38.22.71.62.82.82.82.8-1.52.92.72.71.6
Saline control response1.52.010.1-0.52.10.21.41.4-0.0-3.20.60.30.5-1.6
Bone: connectivity density1.82.94.3-1.3-1.7-1.8-2.1-2.1-1.91.2-1.8-1.5-2.0-0.9
Bone: cortical apparent density0.50.72.3-1.11.1-0.50.20.2-0.8-1.4-0.3-0.5-0.2-1.5
Bone: cortical area1.01.63.00.91.31.41.71.71.2-0.71.31.11.40.4
Bone: cortical porosity0.40.51.00.21.00.40.90.90.8-1.00.40.20.50.5
Bone: cortical porosity0.60.71.50.80.60.80.90.91.2-0.50.70.60.81.0
Bone: cortical thickness1.42.48.2-1.02.90.31.91.9-0.1-2.40.3-0.20.6-1.7
Bone: cortical thickness1.31.54.2-1.51.7-0.60.70.7-1.0-2.1-0.4-0.7-0.3-2.0
Bone: cortical tissue density0.40.61.9-1.01.0-0.50.10.1-0.7-1.3-0.3-0.4-0.2-1.4
Condit. Reinf. active minus inactive responses0.60.71.1-0.6-0.9-1.0-1.0-1.0-0.80.5-1.0-0.9-1.0-0.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.50.3-0.40.10.1-0.3-0.6-0.3-0.4-0.3-0.6
Condit. Reinf. active responses1.21.52.2-1.0-1.1-1.4-1.3-1.3-1.40.6-1.4-1.3-1.5-0.9
Condit. Reinf. inactive responses2.83.45.7-1.9-1.0-2.0-1.8-1.8-2.40.4-2.1-2.0-2.2-1.8
Incentive salience index mean1.01.23.80.1-1.9-0.6-1.2-1.2-0.52.0-0.8-0.6-0.90.5
Condit. Reinf. lever presses1.82.610.70.6-2.9-0.4-1.7-1.7-0.43.3-0.8-0.4-0.91.2
Condit. Reinf. active minus inactive responses1.11.52.21.20.61.31.41.41.5-0.71.41.31.40.9
Condit. Reinf. active-inactive response ratio2.93.35.81.90.92.01.91.92.4-0.42.01.92.11.8
Condit. Reinf. active responses0.00.00.10.3-0.40.0-0.0-0.00.2-0.20.20.30.10.2
Condit. Reinf. inactive responses1.31.72.8-1.0-1.1-1.4-1.6-1.6-1.70.1-1.2-1.0-1.4-1.2
Condit. Reinf. lever presses0.40.51.0-0.3-1.0-0.8-1.0-1.0-0.60.2-0.7-0.6-0.8-0.2
Condit. Reinf. lever reinforcers received0.00.10.20.3-0.5-0.1-0.2-0.20.10.00.10.20.00.3
Conditioned reinforcement - actives0.71.23.9-0.22.00.51.81.90.4-0.90.40.20.5-0.7
Conditioned reinforcement - inactives0.60.84.0-0.22.00.41.31.40.3-0.90.40.20.6-0.3
Conditioned locomotion0.20.30.80.40.70.50.80.90.50.30.50.50.50.2
Patch foraging indifference point 0 sec0.50.95.3-1.01.6-0.50.00.0-0.7-2.3-0.0-0.2-0.0-0.6
Patch foraging indifference point AUC0.71.12.30.80.81.11.51.51.1-0.60.90.61.10.8
Delay disc. indifference point, 0s delay0.60.71.70.90.51.00.70.70.80.50.80.70.91.3
Delay disc. indifference point, 16s delay0.90.93.0-0.81.70.01.31.3-0.1-1.70.1-0.40.5-0.2
Delay disc. indifference point, 2s delay1.82.03.21.41.31.51.11.11.6-0.21.61.41.81.8
Delay disc. indifference point, 24s delay0.20.21.1-0.00.50.20.50.40.4-1.10.40.20.60.4
Delay disc. indifference point, 4s delay2.42.54.21.51.11.72.02.11.7-0.91.71.51.71.0
Delay disc. indifference point, 8s delay0.10.10.40.10.30.30.60.50.2-0.20.20.00.30.4
Indifference point function ln k0.20.31.40.4-1.00.0-0.3-0.30.21.2-0.10.1-0.10.9
Indifference point function log k0.20.31.40.4-1.00.0-0.3-0.30.21.2-0.10.1-0.10.9
Patch foraging total patch changes 0 sec0.61.16.3-1.11.8-0.40.30.3-0.6-2.5-0.0-0.20.1-0.7
Patch foraging total patch changes 12 sec0.60.84.2-0.81.6-0.20.60.6-0.4-2.10.1-0.20.3-0.4
Patch foraging total patch changes 18 sec1.32.04.7-2.11.3-1.3-0.2-0.1-1.6-2.2-1.0-1.3-0.9-1.7
Patch foraging total patch changes 24 sec1.73.06.2-2.50.7-2.0-1.1-1.2-2.2-1.5-1.7-2.0-1.6-1.7
Patch foraging total patch changes 6 sec0.91.36.0-1.41.7-0.70.10.2-1.0-2.4-0.3-0.5-0.0-1.5
Patch foraging time to switch 0 sec0.40.82.8-1.20.0-0.9-0.7-0.7-1.3-0.5-0.7-0.6-0.7-1.7
Patch foraging water rate 0 sec0.30.61.60.40.50.70.91.00.8-0.40.80.60.91.3
Patch foraging water rate 12 sec0.20.41.0-1.00.2-0.8-0.1-0.0-0.6-0.5-0.8-0.9-0.7-0.6
Patch foraging water rate 18 sec0.20.30.70.5-0.00.60.80.80.5-0.50.60.50.40.2
Patch foraging water rate 24 sec0.81.13.60.31.00.91.91.90.8-0.90.70.40.80.2
Patch foraging water rate 6 sec0.10.10.4-0.70.1-0.40.30.3-0.3-0.4-0.3-0.5-0.2-0.1
Seeking ratio, delayed vs. immediate footshock0.40.51.00.50.90.51.00.90.6-0.90.60.50.50.3
Distance traveled before self-admin0.40.51.21.1-0.11.00.40.20.70.80.81.00.60.3
Distance traveled after self-admin1.21.52.51.41.01.50.90.81.4-0.61.51.61.40.6
Extensor digitorum longus weight0.10.61.31.1-0.40.90.20.20.80.60.81.00.70.8
Bone: elastic displacement0.40.51.6-0.81.0-0.40.40.4-0.4-1.3-0.4-0.6-0.3-1.0
Bone: elastic work1.11.43.10.31.81.01.71.70.8-1.40.90.61.1-0.4
Bone: endosteal estimation4.810.619.24.4-0.23.82.32.34.10.73.84.13.43.5
Bone: endosteal perimeter2.24.610.13.2-1.82.10.40.42.52.02.02.51.73.1
Epididymis fat weight3.311.231.4-4.54.4-2.31.00.8-3.2-5.1-1.5-2.3-1.1-5.6
Delta time in closed arm before/after self-admin0.40.40.90.50.50.70.30.40.7-0.40.80.70.90.7
Delta time in open arm before/after self-admin0.20.20.70.10.30.20.70.7-0.1-0.40.20.1-0.0-0.9
Diff in mean of infusions in LGA sessions3.34.07.1-1.7-1.0-2.2-2.7-2.7-1.91.9-2.3-2.1-2.10.3
Delay discount exponential model param1.01.12.2-0.6-0.9-1.0-1.5-1.5-0.90.9-1.0-0.7-1.2-0.9
Extinction: sum of active levers before priming0.50.61.8-0.0-0.9-0.4-1.2-1.10.10.9-0.3-0.2-0.21.3
Active lever presses in extinction session 60.50.51.0-1.00.2-0.8-0.7-0.6-1.0-0.5-0.7-0.8-0.6-0.8
Bone: final force2.84.59.10.73.02.03.03.01.4-2.22.01.52.1-0.6
Bone: final moment2.54.18.20.72.81.92.92.91.3-2.11.91.52.0-0.6
Food consumed during 24 hour testing period1.01.42.41.5-0.01.51.21.21.10.31.41.51.20.8
Glucose2.64.111.62.6-2.71.3-0.6-0.61.73.11.11.60.93.4
Heart weight1.93.04.91.22.01.71.81.81.8-1.22.01.82.21.1
Delay discount hyperbolic model param1.01.22.3-0.6-1.0-1.0-1.5-1.5-1.00.9-1.0-0.7-1.3-1.0
Intermittent access intake day 1-15 change0.10.10.4-0.1-0.3-0.2-0.2-0.2-0.40.1-0.3-0.3-0.4-0.7
Intermittent access intake escalation0.20.41.8-0.50.3-0.30.00.1-0.6-0.7-0.4-0.5-0.6-1.3
Intermittent access intake escalation 20.10.10.40.7-0.50.40.10.10.20.30.20.2-0.1-0.2
Intermitt. access day 1 inactive lever presses0.51.94.61.7-0.41.50.30.41.71.21.41.51.62.1
Intermitt. access day 15 inactive lever presses0.71.42.41.00.71.41.51.61.3-0.71.31.21.4-0.1
Intermitt. access escalation Index1.72.45.0-0.7-2.2-1.4-1.8-1.8-1.42.2-1.5-1.3-1.60.2
Intermittent access day 1 total infusions0.60.92.0-1.31.4-1.0-0.3-0.2-1.1-0.1-1.1-1.1-0.9-1.1
Intermittent access day 15 total infusions0.60.92.5-1.01.6-0.70.30.3-1.0-0.8-0.8-0.9-0.9-1.5
Intermittent access terminal intake (last 3 days)0.50.73.3-0.81.8-0.40.60.7-0.5-0.9-0.3-0.5-0.2-1.0
Intermittent access total infusions0.50.62.5-0.81.6-0.40.50.6-0.6-0.6-0.4-0.5-0.4-1.0
Intermittent access day 1 locomotion0.20.30.9-0.40.7-0.40.00.1-0.70.1-0.4-0.3-0.6-1.0
Intermittent access day 15 total locomotion0.91.75.00.91.41.22.22.20.8-0.41.11.00.9-0.6
Intermittent access total locomotion0.91.13.40.41.50.81.81.90.5-0.80.70.60.4-0.9
Intermittent access standard deviation0.91.95.70.12.40.91.71.80.6-2.01.10.91.1-0.9
Left kidney weight3.214.828.02.44.23.95.35.23.2-3.74.03.63.9-0.2
Right kidney weight3.616.430.82.84.44.35.65.43.4-3.54.33.94.1-0.2
Cocaine induced anxiety0.50.82.80.6-1.70.1-1.0-1.0-0.01.50.00.2-0.11.0
Post-drug Anxiety0.60.61.90.3-1.4-0.1-1.2-1.2-0.00.80.00.2-0.00.9
Baseline Anxiety0.40.40.9-0.90.0-1.0-0.8-0.8-0.4-0.5-0.6-0.6-0.3-0.2
Tail length4.417.225.54.82.25.04.34.24.7-1.24.94.84.62.7
Length with tail6.126.541.05.92.86.45.45.45.7-1.46.16.15.73.0
Length without tail5.317.026.04.32.75.14.64.54.3-1.04.94.94.72.1
Times rat made contact with spout3.13.55.3-2.30.1-2.2-1.3-1.3-2.3-1.1-2.1-2.2-2.1-2.2
Lifetime Intake0.50.64.0-0.62.0-0.10.60.7-0.3-0.7-0.1-0.3-0.1-0.9
Liver weight, left2.54.18.52.9-0.62.41.31.22.31.02.32.71.92.3
Liver weight, right3.86.611.73.40.43.22.12.13.10.42.93.12.72.5
Locomotor activity1.92.96.32.5-0.92.01.41.42.20.01.92.11.51.6
Locomotor testing distance0.61.12.31.5-1.11.10.40.41.30.41.11.30.91.3
Locomotor testing rearing0.61.32.51.6-0.51.40.90.91.30.01.41.51.10.4
Locomotion in novel chamber0.70.83.00.41.00.71.71.70.4-0.60.60.40.60.1
Locomotion in novel chamber post-restriction0.50.81.60.20.90.71.11.20.5-1.30.90.80.9-0.6
Fecal boli incidents, locomotor time 10.30.41.1-0.50.3-0.7-0.8-1.1-0.80.2-0.5-0.3-0.7-0.1
Change in fecal boli incidents, locomotor task1.41.32.71.20.31.30.50.71.40.81.31.21.61.6
Time >=10cm from walls, locomotor time 12.12.24.11.80.11.70.91.11.80.51.82.01.71.6
Bouts of movement, locomotor time 10.50.63.3-0.0-1.8-0.5-0.4-0.5-0.50.7-0.7-0.6-0.9-0.2
Total resting periods, locomotor time 10.20.21.50.2-1.2-0.10.0-0.1-0.20.6-0.4-0.2-0.60.0
Rest time, locomotor task time 10.40.41.31.1-0.00.90.20.30.70.20.80.90.60.7
Distance moved, locomotor task time 10.20.30.8-0.20.90.30.60.70.3-0.70.30.20.5-0.2
Vertical activity count, locomotor time 10.00.10.3-0.30.10.10.50.50.1-0.60.20.10.3-0.5
Time >=10cm from walls, locomotor time 20.81.22.41.3-0.31.00.20.41.30.71.31.51.31.5
Bouts of movement, locomotor time 20.50.71.61.3-0.61.01.21.20.9-0.10.70.80.40.4
Total resting periods, locomotor time 20.50.92.31.5-1.01.11.11.01.00.40.80.90.40.8
Rest time, locomotor task time 21.01.33.31.8-1.61.10.30.11.01.70.81.10.41.0
Distance moved, locomotor task time 20.40.51.8-0.81.3-0.00.20.5-0.2-1.30.2-0.00.4-0.7
Vertical activity count, locomotor time 20.10.10.5-0.5-0.3-0.3-0.7-0.5-0.2-0.50.1-0.00.2-0.0
Light reinforcement 10.10.10.5-0.50.7-0.1-0.4-0.4-0.5-0.0-0.1-0.10.10.3
Light reinforcement 20.50.71.61.10.31.30.50.50.80.31.11.11.00.6
Bone: marrow area4.810.418.94.4-0.23.82.32.34.00.63.84.13.43.4
Bone: maximum diameter1.52.85.42.3-0.61.90.90.92.21.31.61.81.52.3
Bone: maximum force2.44.28.41.02.52.12.92.91.5-1.82.01.72.1-0.3
Bone: maximum moment2.23.97.61.12.32.12.82.81.6-1.72.01.72.1-0.2
Mean time between licks in bursts0.81.84.71.9-1.61.1-0.1-0.11.32.10.81.10.62.2
Mean num. licks in bursts1.72.77.9-2.01.0-1.4-0.3-0.3-1.9-2.3-1.3-1.4-1.4-2.8
Cd content in liver0.40.51.3-0.90.2-0.6-0.6-0.5-1.0-0.3-0.6-0.5-0.6-1.1
Co content in liver0.50.62.1-0.61.30.00.70.6-0.1-1.40.40.20.5-0.9
Cu content in liver3.44.06.0-2.4-0.5-2.5-1.8-1.8-2.4-0.4-2.3-2.4-2.3-1.9
Fe content in liver0.40.52.3-0.51.10.00.70.7-0.1-1.50.2-0.10.2-1.0
K content in liver0.30.30.7-0.7-0.4-0.5-0.2-0.3-0.60.4-0.7-0.8-0.5-0.2
Mg content in liver0.90.94.10.4-1.4-0.1-0.8-0.80.12.0-0.3-0.2-0.21.4
Mn content in liver2.22.58.91.5-2.70.5-1.2-1.30.73.00.30.80.22.1
Na content in liver0.40.40.9-1.00.7-0.40.60.5-0.4-0.6-0.5-0.9-0.2-0.7
Rb content in liver0.60.71.4-0.5-1.2-0.8-1.2-1.1-1.00.9-0.8-0.6-0.7-0.1
Se content in liver1.41.64.71.7-1.70.8-0.2-0.31.32.00.50.70.42.2
Sr content in liver0.90.81.21.10.01.11.00.81.10.11.01.10.90.6
Zn content in liver0.10.10.30.4-0.40.2-0.1-0.10.10.50.20.30.20.5
Bone: minimum diameter2.03.77.62.7-0.82.21.11.12.21.32.12.41.92.3
Time in familiar zone, hab. session 15.65.48.5-2.7-0.5-2.7-2.0-2.0-2.9-0.8-2.6-2.6-2.6-2.6
Time in novel zone, hab. session 13.63.65.42.30.22.21.41.42.30.62.22.32.12.2
Total zone transitions, hab. session 10.50.71.1-0.7-0.7-0.9-1.0-1.0-1.00.6-0.9-0.8-0.8-0.3
Total locomotion distance, hab. session 10.40.61.2-0.8-0.5-0.8-0.9-0.9-1.10.5-0.9-0.8-0.8-0.4
Locomotion velocity, hab. session 10.20.30.7-0.7-0.1-0.7-0.6-0.6-0.80.2-0.7-0.7-0.5-0.3
Time in familiar zone, hab. session 20.80.82.0-1.10.1-1.0-0.6-0.6-1.1-0.7-0.9-0.9-1.0-1.4
Time in novel zone, hab. session 20.40.40.60.60.30.70.60.60.8-0.10.70.70.70.7
Total zone transitions, hab. session 20.10.10.2-0.50.1-0.3-0.2-0.2-0.50.4-0.3-0.4-0.1-0.4
Total locomotion distance, hab. session 21.01.42.1-1.1-0.9-1.2-1.3-1.3-1.41.2-1.3-1.2-1.1-0.6
Locomotion velocity, hab. session 21.11.52.1-1.1-1.0-1.1-1.4-1.4-1.41.5-1.3-1.2-1.1-0.5
Novel to familiar place preference ratio0.10.10.2-0.40.4-0.3-0.0-0.0-0.1-0.2-0.3-0.4-0.1-0.0
Novelty place preference0.10.10.3-0.20.5-0.00.20.20.2-0.3-0.0-0.20.10.1
Time in novel zone, NPP test0.10.10.40.00.60.20.40.40.4-0.40.1-0.00.30.3
Total zone transitions, NPP test0.91.31.9-0.8-1.2-1.1-1.4-1.4-1.31.4-1.2-1.1-1.1-0.3
Total locomotion distance, NPP test1.11.52.6-1.2-0.7-1.2-1.3-1.3-1.61.1-1.3-1.2-1.2-0.7
Locomotion velocity, NPP test1.82.54.0-1.6-1.1-1.6-1.8-1.8-2.01.4-1.8-1.6-1.6-0.9
Intraocular pressure0.81.12.2-1.0-0.5-1.2-1.1-1.1-1.30.1-1.2-1.0-1.5-0.6
Delta distance traveled before/after self-admin1.41.53.30.61.81.01.11.21.1-1.81.21.01.30.6
Delta ambulatory time before/after self-admin1.01.31.60.91.11.11.21.21.2-1.21.21.11.31.0
Parametrial fat weight0.81.94.70.41.61.12.22.20.6-1.71.11.00.8-1.1
Pavlov. Cond. lever latency1.31.66.9-1.32.1-0.50.40.4-0.9-2.6-0.0-0.20.1-1.9
Pavlov. Cond. magazine entry latency1.01.34.70.9-2.2-0.1-1.0-1.00.31.9-0.4-0.1-0.61.6
Pavlov. Cond. change in total contacts0.90.91.91.4-0.41.10.90.91.40.80.70.70.71.3
Pavlov. Cond. index score1.51.97.21.3-2.50.3-0.8-0.80.62.7-0.20.1-0.42.0
Pavlov. Cond. latency score1.41.87.01.4-2.20.5-0.5-0.50.92.6-0.00.2-0.12.1
Pavlov. Cond. lever contacts1.51.87.11.5-1.90.8-0.2-0.21.02.70.30.50.22.0
Pavlov. Cond. magazine entry number1.11.45.5-0.62.40.51.41.40.1-1.80.60.30.8-1.2
Pavlov. Cond. intertrial magazine entries1.51.84.1-1.80.5-1.4-0.8-0.8-1.7-0.9-1.2-1.2-1.2-2.0
Pavlov. Cond. lever-magazine prob. diff.1.51.97.11.1-2.60.1-1.0-1.00.42.7-0.3-0.1-0.51.9
Pavlov. Cond. response bias1.41.86.51.0-2.6-0.0-1.2-1.20.32.4-0.4-0.0-0.61.7
Pavlov. Cond. lever latency0.50.71.10.90.31.00.70.70.90.60.90.91.00.9
Pavlov. Cond. magazine entry latency0.30.30.60.60.30.70.70.70.70.10.50.50.50.5
Pavlov. Cond. change in total contacts0.10.10.5-0.10.50.00.50.50.3-0.70.1-0.10.1-0.1
Pavlov. Cond. index score0.00.00.00.1-0.1-0.10.10.10.1-0.2-0.1-0.1-0.1-0.0
Pavlov. Cond. latency score0.00.00.2-0.00.2-0.00.20.20.1-0.50.0-0.10.0-0.2
Pavlov. Cond. lever contacts0.30.40.6-0.7-0.2-0.8-0.4-0.4-0.6-0.6-0.7-0.7-0.7-0.7
Pavlov. Cond. magazine entry number0.10.20.4-0.3-0.4-0.4-0.6-0.6-0.50.2-0.3-0.2-0.30.0
Pavlov. Cond. intertrial magazine entries0.60.92.70.5-1.6-0.3-1.2-1.2-0.21.5-0.4-0.1-0.60.9
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.0-0.1-0.10.00.0-0.0-0.2-0.1-0.1-0.2-0.1
Pavlov. Cond. response bias0.10.10.3-0.2-0.5-0.4-0.3-0.3-0.30.1-0.5-0.5-0.6-0.1
Time in closed arm before self-admin0.10.10.30.2-0.50.00.50.50.20.40.10.20.20.5
Time in closed arm after self-admin0.40.41.2-0.10.80.41.11.10.3-0.60.50.20.80.3
Time in open arm before self-admin0.10.20.40.0-0.3-0.4-0.6-0.5-0.10.3-0.5-0.4-0.60.3
Time in open arm after self-admin0.00.10.20.3-0.2-0.1-0.4-0.3-0.10.2-0.10.1-0.4-0.1
Bone: periosteal estimation3.37.110.63.20.73.22.42.43.3-0.23.13.23.02.3
Bone: periosteal perimeter1.62.85.22.3-0.22.01.31.32.20.61.81.91.71.9
Bone: post-yield work1.11.73.71.9-1.71.2-0.1-0.11.21.51.11.50.81.7
Progressive ratio test 1 active lever presses0.20.31.8-0.61.3-0.30.40.4-0.3-0.3-0.2-0.2-0.0-0.4
Progressive ratio test 1 breakpoint0.20.31.9-0.51.4-0.20.40.5-0.2-0.4-0.1-0.20.1-0.3
Progressive ratio test 1 inactive lever presses0.40.61.4-1.21.2-0.70.20.3-0.6-0.8-0.5-0.7-0.3-1.0
Progressive ratio test 2 active lever presses0.70.81.4-1.20.7-1.0-0.2-0.1-1.0-0.1-1.1-1.1-1.0-1.2
Progressive ratio test 2 breakpoint0.80.91.6-1.30.7-1.1-0.2-0.1-1.0-0.2-1.1-1.2-1.1-1.3
Progressive ratio test 2 inactive lever presses0.30.51.80.31.30.61.01.10.60.20.50.40.60.3
Incentive Sensitization - Responses0.60.91.4-0.9-0.2-1.1-0.8-0.7-0.90.3-1.2-1.2-1.2-1.0
Incentive Sensitization - Breakpoint0.81.01.7-1.0-0.3-1.2-0.7-0.7-1.00.3-1.3-1.3-1.3-1.2
Sum of active levers in priming session hrs 5-60.20.20.40.0-0.7-0.4-0.6-0.6-0.20.3-0.2-0.1-0.30.4
Progressive ratio3.25.013.60.93.71.92.82.81.4-2.72.11.82.1-0.9
Food seeking constrained by brief footshock0.10.10.4-0.30.1-0.40.10.2-0.4-0.4-0.3-0.3-0.4-0.6
Seeking ratio, punishment vs. effort2.63.810.6-0.8-3.3-1.8-2.4-2.3-1.22.3-1.8-1.6-1.80.9
Retroperitoneal fat weight0.21.02.70.21.30.91.71.60.3-1.00.70.50.5-0.8
Reaction time number correct0.30.52.5-1.00.8-0.50.50.5-0.5-1.6-0.1-0.3-0.0-0.5
Reaction time mean minus median0.51.13.81.8-2.01.00.10.10.81.70.40.7-0.2-0.4
Reaction time mean minus median AUC0.30.83.71.3-1.90.6-0.0-0.00.51.70.10.3-0.4-0.4
Reaction time num false alarms0.30.40.60.6-0.00.70.80.80.80.30.50.40.70.8
Reaction time num false alarms AUC0.50.81.80.80.20.91.01.01.10.20.70.51.01.4
Reaction time trials correct on left0.30.52.5-1.00.8-0.50.50.5-0.5-1.6-0.1-0.3-0.0-0.5
Reaction time trials on left0.20.42.4-0.90.8-0.40.50.5-0.4-1.5-0.0-0.20.0-0.4
Reaction time mean1.11.76.81.8-2.20.9-0.4-0.41.02.60.40.80.00.7
Reaction time mean AUC1.01.66.41.8-2.20.9-0.4-0.50.92.50.40.8-0.00.6
Median of all reaction times0.91.35.41.5-1.80.8-0.4-0.50.92.30.40.80.20.9
Reaction time omissions0.71.03.61.6-1.30.9-0.3-0.31.01.90.50.80.10.7
Reaction time false alarm rate0.71.02.21.3-0.31.10.60.61.31.10.70.70.91.5
Reaction time premature initiation rate1.01.42.40.81.41.31.41.41.2-0.71.41.21.50.2
Reaction time premature initiations1.01.83.50.21.91.01.71.71.0-1.61.31.11.5-0.0
Std. dev. reaction times0.91.64.72.2-1.71.40.20.21.42.00.81.10.30.7
Reaction time trials completed0.20.42.4-0.90.8-0.40.50.5-0.4-1.5-0.0-0.20.0-0.4
Reaction time trials AUC0.20.42.1-0.90.7-0.50.40.5-0.4-1.5-0.1-0.3-0.0-0.4
Run reversals in cocaine runway, females0.50.51.5-0.91.0-0.60.10.1-0.7-0.8-0.4-0.5-0.3-1.2
Run reversals in cocaine runway, males1.31.33.21.80.01.70.90.91.50.61.21.30.90.6
Latency to leave start box in cocaine runway0.20.21.10.1-0.60.1-0.3-0.30.31.0-0.1-0.10.20.9
Latency to leave start box in cocaine runway, F0.40.42.2-0.0-1.5-0.3-0.5-0.6-0.01.2-0.4-0.3-0.20.5
Latency to leave start box in cocaine runway, M0.60.61.50.41.20.80.80.90.7-0.20.70.60.90.8
Std. dev. time between licks in bursts2.33.29.02.4-1.41.60.30.32.12.01.51.71.43.0
Total sessions with >9 infusions0.40.53.1-0.41.80.00.60.7-0.1-0.70.0-0.10.1-1.1
Short access day 1 total inactive lever presses2.22.84.71.71.32.02.12.22.00.11.71.61.70.8
Short access day 10 total inactive lever presses0.10.30.7-0.1-0.5-0.3-0.8-0.8-0.30.9-0.4-0.4-0.40.1
Short access day 1 total infusions0.10.21.2-0.31.1-0.2-0.3-0.2-0.30.1-0.2-0.2-0.1-0.5
Short access day 10 total infusions0.50.62.8-0.71.7-0.20.80.9-0.4-0.9-0.3-0.4-0.3-0.9
Short access total infusions0.40.64.1-0.52.00.00.70.8-0.2-0.60.0-0.10.1-0.7
Short access day 1 locomotion0.91.21.7-1.0-0.4-1.2-1.3-1.2-1.11.0-1.3-1.2-1.2-0.5
Short access day 10 total locomotion0.91.62.51.6-0.21.31.01.11.50.31.51.61.51.2
Short access total locomotion0.20.30.40.50.20.40.30.40.50.60.50.60.60.6
One hour access (0.3 mA shock)1.41.62.8-1.2-0.0-1.4-1.3-1.2-1.30.8-1.7-1.6-1.7-0.7
Compulsive drug intake2.42.89.10.0-2.7-0.8-2.1-2.2-0.63.0-1.0-0.6-0.91.3
One hour access (shock baseline)0.81.24.1-0.81.8-0.30.70.7-0.6-1.7-0.5-0.6-0.7-2.0
Social response proportion0.80.92.41.2-0.00.90.20.21.10.21.11.31.11.5
Social responses0.60.82.20.80.40.80.70.61.1-0.31.01.01.11.5
Social time1.42.04.42.1-1.41.50.40.41.72.01.01.30.91.3
Soleus weight2.67.617.13.7-1.22.91.01.03.32.62.73.12.74.1
Bone: stiffness0.40.61.2-0.11.10.51.11.1-0.0-1.10.50.40.6-0.9
Tibialis anterior weight0.20.82.2-1.21.1-0.60.20.2-1.0-1.2-0.5-0.7-0.4-1.5
Time to tail flick, vehicle, before self-admin0.60.61.5-0.5-1.0-0.7-0.5-0.8-0.60.7-1.0-0.9-1.2-0.4
Time to tail flick, vehicle, after self-admin0.20.31.40.4-0.9-0.1-0.4-0.5-0.11.2-0.3-0.1-0.40.5
Time to tail flick, test, before self-admin0.30.31.0-0.5-0.4-0.5-0.0-0.2-0.6-0.4-0.6-0.6-0.7-1.0
Time to tail flick, test, after self-admin0.80.91.9-0.4-1.0-0.7-0.9-0.9-0.90.1-1.1-1.0-1.4-1.1
Delta time to tail flick, vehicle, before/after SA0.20.20.4-0.50.1-0.4-0.5-0.4-0.60.2-0.4-0.5-0.4-0.4
Delta time to tail flick, test, before/after SA0.50.50.8-0.8-0.3-0.8-0.7-0.6-0.80.1-0.9-0.9-0.9-0.7
Tibia length3.39.214.63.70.83.72.72.83.5-0.13.73.83.52.5
Ambulatory time before self-admin0.10.10.30.50.10.60.30.00.30.50.40.40.3-0.2
Ambulatory time after self-admin1.31.52.31.41.21.51.21.01.3-0.71.51.51.40.6
Bone: tissue strength2.42.44.90.82.11.62.22.21.2-1.31.51.21.6-0.3
Total heroin consumption0.10.10.20.50.10.30.00.10.40.20.30.30.20.2
Bone: trabecular number2.23.76.1-2.3-0.6-2.1-1.5-1.5-2.50.3-2.3-2.3-2.3-1.9
Bone: trabecular spacing4.35.78.72.41.52.72.52.52.9-0.82.82.62.81.8
Bone: trabecular thickness1.82.23.4-1.6-0.8-1.6-1.3-1.3-1.90.3-1.7-1.7-1.8-1.5
Bone: trabecular tissue density0.81.12.40.61.31.01.51.51.1-1.00.90.61.10.3
Water consumed over 24 hours0.10.10.40.4-0.20.40.20.20.40.40.30.30.40.6
Number of responses in last shaping day1.41.53.81.20.81.20.70.71.60.31.41.31.71.9