Tbkbp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr10_82133847_82135618	0.04	0.03	7.4e-03	0.01	0.01	0.01	0.01	8.3e-03	1.5e-02	6.8e-03	7.2e-03
2	Liver	intron excision ratio	chr10_82133847_82134261	0.04	0.03	6.0e-03	0.01	0.01	0.01	0.01	1.3e-02	1.4e-02	6.8e-03	7.2e-03
3	Liver	gene expression	Tbkbp1	0.1	0.09	6.7e-05	0.01	0.03	0.03	0.02	3.5e-02	2.4e-04	3.0e-04	1.1e-03
4	pVTA	gene expression	Tbkbp1	0.09	0.06	1.6e-03	0.08	0.07	0.06	0.07	2.1e-04	5.0e-04	9.9e-04	5.6e-04
5	NAcc	gene expression	Tbkbp1	0.45	0.09	0.0e+00	0.41	0.42	0.42	0.42	1.0e-51	1.9e-52	5.9e-52	4.8e-52
6	Brain	gene expression	Tbkbp1	0.16	0.11	3.4e-07	0.08	0.06	0.07	0.08	3.9e-08	1.1e-06	1.8e-07	1.2e-07
7	Brain	mRNA stability	Tbkbp1	0.06	0.04	3.2e-04	0.04	0.03	0.03	0.03	2.2e-04	8.7e-04	1.5e-03	3.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	1.0	1.7	5.3	0.3	-0.2	2.3	1.1	-1.4	1.3	1.3
Area under the delay curve	1.2	1.2	2.0	1.1	-1.1	0.8	-1.4	1.0	-1.1	-1.1
BMI with tail	6.0	19.4	32.9	-5.6	5.7	2.2	3.6	-4.0	4.4	4.3
BMI without tail	0.4	0.9	2.5	-1.5	1.6	1.0	0.1	-0.3	0.3	0.3
Body weight	2.3	9.8	20.9	-4.6	4.5	-2.1	-2.8	2.4	-2.2	-2.2
Weight adjusted by age	0.4	0.4	1.1	0.2	-0.3	-1.1	-0.6	0.7	-0.6	-0.6
Bone surface	0.1	0.2	0.7	-0.8	0.8	0.4	-0.4	0.0	-0.0	-0.0
Bone volume	0.3	0.6	1.2	-0.9	1.0	1.1	0.2	-0.6	0.5	0.6
Breakpoint value in progressive ratio session	2.3	2.6	4.7	0.4	-0.5	-2.2	-1.6	1.9	-1.8	-1.9
Number of licking bursts	0.2	0.2	0.5	0.7	-0.7	0.3	0.2	-0.4	0.4	0.3
Context. condit. distance diff. score	0.2	0.3	0.9	-1.0	1.0	-0.2	0.1	-0.1	0.1	0.2
Locomotion velocity, session 1	0.6	0.6	1.8	-1.3	1.3	-0.4	0.3	-0.3	0.5	0.5
Locomotion distance, session 1	2.9	3.8	7.3	-0.6	0.5	-2.7	-2.1	2.3	-2.1	-2.1
Locomotion velocity, session 2	1.7	2.0	3.4	-0.1	0.1	-1.0	-1.9	1.8	-1.8	-1.8
Locomotion distance, session 2	2.6	3.7	5.6	0.3	-0.4	-2.1	-2.4	2.4	-2.2	-2.3
Locomotion velocity, session 3	0.2	0.2	0.5	-0.1	0.1	-0.2	-0.6	0.7	-0.7	-0.6
Locomotion distance, session 3	2.9	3.1	4.9	0.5	-0.6	-1.6	-2.1	2.2	-2.2	-2.1
Stereotopy head waving bouts, day 3	3.4	4.0	9.9	0.3	-0.2	3.1	2.3	-2.2	1.9	2.0
Stereotopy head waving duration, day 3	1.5	1.8	4.3	-0.4	0.5	2.1	1.6	-1.4	1.3	1.4
Locomotion velocity, session 7	1.4	1.5	2.3	0.4	-0.5	-1.2	-1.5	1.5	-1.4	-1.4
Locomotion distance, session 7	3.7	4.7	6.6	1.6	-1.7	-1.4	-2.5	2.5	-2.5	-2.6
Stereotopy head waving bouts, day 7	1.0	1.1	2.1	0.2	-0.1	1.0	1.4	-1.2	1.1	1.3
Stereotopy head waving duration, day 7	0.6	0.7	1.7	-0.1	0.1	0.3	1.3	-1.0	1.0	1.1
Locomotion velocity, session 8	2.1	2.5	6.1	-2.5	2.4	-2.0	-0.7	0.7	-0.5	-0.4
Locomotion distance, session 8	1.3	1.9	2.8	-0.7	0.6	-1.7	-1.5	1.6	-1.5	-1.4
Degree of sensitization distance	0.1	0.1	0.1	-0.1	0.1	-0.3	-0.3	0.3	-0.2	-0.3
Degree of sensitization stereotypy	0.9	1.0	1.3	1.1	-1.0	0.4	1.2	-1.0	0.9	1.0
Conditioned locomotion	0.3	0.4	1.5	-0.5	0.5	1.2	0.3	-0.4	0.4	0.3
Cocaine response after cond. corrected	2.2	2.5	9.4	-0.7	0.8	3.1	1.4	-1.4	1.3	1.2
Cocaine response after cond. not corrected	1.5	1.7	9.7	0.2	-0.1	3.1	0.8	-0.8	0.6	0.5
Cocaine response before conditioning	1.8	2.2	5.1	2.2	-2.3	-0.0	-1.0	1.1	-1.2	-1.2
Saline control response	0.3	0.3	1.2	1.1	-1.1	0.2	0.3	-0.1	0.1	0.1
Bone: connectivity density	0.8	1.3	2.8	1.2	-1.2	1.7	0.7	-1.0	0.9	0.8
Bone: cortical apparent density	3.1	4.1	14.1	3.7	-3.8	-0.4	-0.2	0.2	-0.2	-0.4
Bone: cortical area	0.1	0.2	0.4	0.2	-0.2	0.7	-0.5	0.3	-0.5	-0.3
Bone: cortical porosity	0.4	0.5	1.7	0.3	-0.3	1.3	0.7	-0.6	0.5	0.6
Bone: cortical porosity	0.5	0.5	2.2	0.6	-0.6	1.5	0.5	-0.4	0.3	0.3
Bone: cortical thickness	0.6	1.0	2.1	1.5	-1.5	0.8	-0.6	0.6	-0.8	-0.7
Bone: cortical thickness	2.8	3.3	7.3	2.7	-2.7	1.6	-1.0	1.0	-1.4	-1.3
Bone: cortical tissue density	3.2	4.2	14.4	3.8	-3.8	-0.4	-0.2	0.2	-0.2	-0.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	0.7	-0.7	0.3	-0.1	-0.2	0.2	0.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.1	0.5	-0.5	1.0	0.6	-0.8	0.8	0.7
Condit. Reinf. active responses	0.2	0.2	0.5	0.7	-0.7	0.4	0.2	-0.4	0.4	0.4
Condit. Reinf. inactive responses	0.2	0.2	0.6	0.8	-0.8	0.1	0.2	-0.2	0.2	0.1
Incentive salience index mean	0.5	0.5	1.7	1.3	-1.3	0.5	0.0	-0.2	0.2	0.1
Condit. Reinf. lever presses	0.6	0.8	2.6	1.6	-1.6	-0.0	0.0	-0.1	0.1	0.1
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	0.7	-0.6	0.9	0.4	-0.6	0.6	0.6
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.5	-0.0	0.0	0.5	1.1	-1.1	1.2	1.2
Condit. Reinf. active responses	0.5	0.7	1.4	1.2	-1.2	1.0	0.4	-0.5	0.5	0.4
Condit. Reinf. inactive responses	1.1	1.3	4.0	2.0	-2.0	1.1	0.2	-0.2	0.1	0.1
Condit. Reinf. lever presses	0.3	0.4	0.9	0.9	-0.9	-0.4	-0.5	0.5	-0.4	-0.7
Condit. Reinf. lever reinforcers received	0.5	0.7	1.8	1.3	-1.3	0.8	0.3	-0.4	0.4	0.3
Conditioned reinforcement - actives	1.7	1.7	3.6	0.4	-0.4	1.9	1.2	-1.5	1.4	1.5
Conditioned reinforcement - inactives	1.0	1.1	3.3	1.8	-1.8	0.3	0.3	-0.6	0.5	0.6
Conditioned locomotion	2.6	3.1	7.4	-0.2	0.3	2.7	1.6	-2.0	1.9	2.0
Patch foraging indifference point 0 sec	0.6	1.0	4.9	0.4	-0.3	2.2	0.7	-0.7	0.6	0.7
Patch foraging indifference point AUC	0.2	0.2	1.0	-0.3	0.3	-1.0	-0.0	-0.1	0.2	0.2
Delay disc. indifference point, 0s delay	0.9	0.9	2.5	1.6	-1.6	0.2	-0.2	0.7	-0.7	-0.7
Delay disc. indifference point, 16s delay	0.5	0.5	1.9	0.5	-0.5	1.4	-0.9	0.3	-0.4	-0.4
Delay disc. indifference point, 2s delay	1.5	1.7	3.1	1.8	-1.8	1.2	-1.0	0.9	-1.1	-1.0
Delay disc. indifference point, 24s delay	0.7	0.7	2.3	0.3	-0.3	-0.1	-1.5	0.9	-0.8	-1.0
Delay disc. indifference point, 4s delay	4.6	4.9	7.5	1.5	-1.6	-0.2	-2.7	2.7	-2.7	-2.7
Delay disc. indifference point, 8s delay	0.5	0.5	0.8	0.9	-0.9	0.9	-0.7	0.4	-0.4	-0.5
Indifference point function ln k	0.1	0.2	0.4	0.1	-0.1	0.6	-0.3	0.5	-0.7	-0.4
Indifference point function log k	0.1	0.2	0.4	0.1	-0.1	0.6	-0.3	0.5	-0.7	-0.4
Patch foraging total patch changes 0 sec	0.4	0.7	4.1	0.1	-0.1	2.0	0.5	-0.4	0.3	0.4
Patch foraging total patch changes 12 sec	1.3	1.7	4.5	1.3	-1.3	2.1	0.9	-1.1	0.9	1.0
Patch foraging total patch changes 18 sec	1.2	1.5	2.5	-0.5	0.5	1.0	1.5	-1.5	1.6	1.6
Patch foraging total patch changes 24 sec	0.9	1.1	3.1	0.0	0.0	1.8	1.1	-1.1	1.2	1.0
Patch foraging total patch changes 6 sec	0.8	1.2	2.5	0.1	-0.0	1.6	1.0	-1.3	1.4	1.2
Patch foraging time to switch 0 sec	0.2	0.3	0.6	0.0	-0.0	0.4	0.5	-0.7	0.8	0.6
Patch foraging water rate 0 sec	0.2	0.3	0.6	-0.7	0.7	0.8	-0.5	0.4	-0.5	-0.4
Patch foraging water rate 12 sec	0.7	1.0	1.8	-0.3	0.3	-0.5	-1.2	1.3	-1.4	-1.3
Patch foraging water rate 18 sec	1.2	1.6	2.2	1.5	-1.5	0.5	-1.2	1.2	-1.4	-1.3
Patch foraging water rate 24 sec	0.2	0.3	1.9	0.1	-0.1	1.4	0.1	-0.2	0.1	0.3
Patch foraging water rate 6 sec	0.3	0.4	1.4	1.2	-1.2	0.5	0.3	-0.1	0.0	0.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.7	-0.2	0.2	0.2	0.8	-0.9	0.8	0.8
Distance traveled before self-admin	0.4	0.4	0.8	0.3	-0.4	-0.4	-0.8	0.8	-0.5	-0.9
Distance traveled after self-admin	1.1	1.2	4.2	-2.0	2.1	0.2	0.4	-0.0	0.2	0.1
Extensor digitorum longus weight	2.6	10.4	23.6	-4.9	4.8	-3.8	-2.2	1.8	-1.3	-1.5
Bone: elastic displacement	0.0	0.0	0.2	-0.1	0.1	0.4	0.2	-0.2	0.2	0.1
Bone: elastic work	0.2	0.3	0.5	-0.1	0.1	0.3	-0.7	0.7	-0.7	-0.7
Bone: endosteal estimation	0.8	1.8	4.8	-2.2	2.2	-0.6	-1.0	0.7	-0.8	-0.6
Bone: endosteal perimeter	0.7	1.4	4.7	-2.2	2.2	-0.6	-0.5	0.3	-0.2	-0.1
Epididymis fat weight	0.2	0.4	0.9	-0.3	0.2	-0.1	-0.9	0.8	-0.8	-0.8
Delta time in closed arm before/after self-admin	1.4	1.4	3.3	-1.8	1.8	-1.4	-0.6	0.6	-0.3	-0.5
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.6	-0.6	-0.4	0.3	-0.2	0.3	0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.7	0.0	-0.0	-0.8	0.1	-0.2	0.1	0.1
Delay discount exponential model param	1.4	1.5	3.0	-0.9	0.9	-0.6	1.7	-1.3	1.4	1.4
Extinction: sum of active levers before priming	0.8	0.8	1.5	-0.0	0.0	-0.9	-0.7	1.2	-1.2	-1.2
Active lever presses in extinction session 6	0.2	0.2	0.3	0.1	-0.0	0.5	0.5	-0.4	0.5	0.2
Bone: final force	0.4	0.6	2.8	0.8	-0.7	1.7	0.1	-0.3	0.0	0.2
Bone: final moment	0.3	0.5	2.9	0.6	-0.6	1.7	-0.0	-0.1	-0.1	0.1
Food consumed during 24 hour testing period	0.9	1.0	3.5	-0.4	0.3	-1.9	-1.0	1.0	-0.9	-0.9
Glucose	0.4	0.5	2.9	0.3	-0.3	1.7	-0.4	0.3	-0.4	-0.5
Heart weight	1.0	1.4	4.8	-2.2	2.2	-0.6	-0.1	0.1	0.1	0.0
Delay discount hyperbolic model param	1.8	1.9	3.3	-1.2	1.2	-0.6	1.8	-1.5	1.5	1.5
Intermittent access intake day 1-15 change	0.7	0.7	1.8	-0.4	0.5	1.3	0.8	-0.9	0.9	0.8
Intermittent access intake escalation	0.9	0.9	1.5	-0.6	0.7	1.2	1.0	-0.9	1.0	0.9
Intermittent access intake escalation 2	0.7	0.7	1.2	-1.1	1.1	0.5	0.7	-0.7	0.8	0.7
Intermitt. access day 1 inactive lever presses	0.7	0.7	2.2	1.5	-1.5	0.3	0.4	-0.4	0.5	0.3
Intermitt. access day 15 inactive lever presses	2.5	2.7	4.8	1.1	-1.0	1.0	1.6	-2.1	2.2	2.0
Intermitt. access escalation Index	1.6	1.4	4.5	-2.1	2.1	0.6	0.1	-0.4	0.4	0.5
Intermittent access day 1 total infusions	0.1	0.1	0.4	0.6	-0.6	0.2	0.0	-0.0	-0.1	-0.1
Intermittent access day 15 total infusions	0.3	0.3	0.9	0.1	-0.1	0.9	0.6	-0.6	0.5	0.5
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.7	0.1	-0.0	0.7	0.8	-0.8	0.8	0.8
Intermittent access total infusions	0.0	0.0	0.2	0.1	-0.0	0.5	0.0	-0.1	0.1	0.1
Intermittent access day 1 locomotion	0.2	0.2	0.7	0.8	-0.8	0.4	-0.1	-0.0	-0.0	-0.1
Intermittent access day 15 total locomotion	0.5	0.5	1.0	0.4	-0.4	1.0	0.8	-0.8	0.7	0.6
Intermittent access total locomotion	0.6	0.7	2.1	0.3	-0.3	1.5	0.7	-0.9	0.8	0.7
Intermittent access standard deviation	0.7	0.7	1.4	-0.4	0.5	1.2	0.9	-0.8	0.9	0.7
Left kidney weight	2.5	7.0	10.3	-2.0	1.9	-1.4	-3.2	3.1	-3.1	-3.1
Right kidney weight	0.8	2.2	3.1	-1.5	1.5	0.2	-1.7	1.6	-1.7	-1.6
Cocaine induced anxiety	0.7	0.9	2.2	-1.5	1.4	-1.2	-0.4	0.3	-0.1	-0.1
Post-drug Anxiety	0.3	0.3	1.1	0.4	-0.4	-1.0	0.4	-0.3	0.4	0.5
Baseline Anxiety	2.0	2.1	2.7	1.7	-1.6	0.9	1.4	-1.5	1.4	1.6
Tail length	10.5	31.8	52.3	2.0	-2.2	-3.8	-6.9	6.9	-7.2	-7.1
Length with tail	10.1	37.1	59.3	-0.1	-0.1	-5.2	-7.6	7.6	-7.7	-7.6
Length without tail	2.2	4.8	6.0	-1.8	1.7	-2.4	-2.4	2.4	-2.3	-2.2
Times rat made contact with spout	0.2	0.2	0.5	0.7	-0.7	0.4	0.3	-0.4	0.3	0.4
Lifetime Intake	0.0	0.0	0.1	0.1	-0.1	0.3	0.0	-0.2	0.1	0.0
Liver weight, left	0.6	0.9	2.0	0.6	-0.6	-1.0	-1.4	1.0	-0.8	-1.0
Liver weight, right	2.3	3.7	6.4	1.2	-1.2	-0.2	-2.5	2.3	-2.3	-2.5
Locomotor activity	1.1	1.7	2.8	0.0	0.1	1.1	1.6	-1.7	1.7	1.6
Locomotor testing distance	3.1	5.2	7.7	1.0	-0.9	2.3	2.8	-2.8	2.7	2.6
Locomotor testing rearing	2.6	4.0	5.1	2.3	-2.2	1.9	2.1	-1.9	1.7	1.8
Locomotion in novel chamber	1.0	1.3	3.7	1.9	-1.9	0.8	-0.5	0.3	-0.4	-0.6
Locomotion in novel chamber post-restriction	1.7	2.1	3.3	-0.5	0.6	1.2	1.8	-1.8	1.8	1.8
Fecal boli incidents, locomotor time 1	1.3	1.4	2.2	-1.5	1.5	0.4	1.1	-1.2	1.2	1.3
Change in fecal boli incidents, locomotor task	1.2	1.1	1.7	1.0	-1.0	-0.5	-1.0	1.2	-1.2	-1.3
Time >=10cm from walls, locomotor time 1	0.7	0.7	2.0	0.9	-0.9	0.4	1.4	-0.6	0.4	0.4
Bouts of movement, locomotor time 1	0.1	0.1	0.6	-0.2	0.1	-0.1	-0.8	0.2	-0.3	-0.3
Total resting periods, locomotor time 1	0.2	0.2	1.1	-0.2	0.2	0.0	-1.0	0.4	-0.4	-0.5
Rest time, locomotor task time 1	0.1	0.1	0.4	-0.1	0.1	0.5	-0.7	0.1	0.2	-0.3
Distance moved, locomotor task time 1	0.4	0.4	0.8	0.8	-0.8	-0.2	-0.4	0.7	-0.9	-0.7
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.0	0.0	-0.2	0.4	0.1	-0.3	-0.2
Time >=10cm from walls, locomotor time 2	1.0	1.0	3.2	1.8	-1.8	0.7	0.4	0.0	-0.2	-0.2
Bouts of movement, locomotor time 2	0.2	0.2	0.4	0.4	-0.4	0.5	0.6	-0.5	0.3	0.5
Total resting periods, locomotor time 2	0.2	0.2	0.5	0.3	-0.2	0.4	0.7	-0.5	0.4	0.6
Rest time, locomotor task time 2	0.4	0.5	3.3	-0.1	0.0	-1.8	-0.3	0.2	0.1	-0.1
Distance moved, locomotor task time 2	1.1	1.3	2.4	0.0	-0.0	0.3	-1.4	1.5	-1.5	-1.6
Vertical activity count, locomotor time 2	0.8	0.9	1.5	-0.3	0.4	0.8	-1.1	1.1	-1.1	-1.2
Light reinforcement 1	1.6	3.0	4.1	1.1	-1.0	1.7	2.0	-2.0	1.9	2.0
Light reinforcement 2	0.2	0.3	0.7	0.5	-0.4	0.8	0.4	-0.6	0.6	0.5
Bone: marrow area	0.7	1.6	4.2	-2.1	2.0	-0.7	-1.0	0.7	-0.8	-0.6
Bone: maximum diameter	0.1	0.2	0.6	-0.6	0.7	0.8	0.0	-0.3	0.2	0.4
Bone: maximum force	0.2	0.3	1.6	-0.5	0.5	1.3	-0.3	0.2	-0.3	-0.2
Bone: maximum moment	0.3	0.5	1.7	-0.6	0.6	1.3	-0.5	0.4	-0.5	-0.4
Mean time between licks in bursts	0.4	0.6	1.6	-1.3	1.3	-0.8	-0.0	0.0	0.1	0.0
Mean num. licks in bursts	0.0	0.1	0.1	0.2	-0.2	-0.0	-0.1	0.3	-0.4	-0.2
Cd content in liver	0.3	0.3	0.9	0.9	-0.9	-0.3	0.0	0.2	-0.3	-0.3
Co content in liver	0.5	0.6	1.5	-1.2	1.2	-0.9	-0.3	0.4	-0.3	-0.3
Cu content in liver	0.7	0.9	4.2	-0.1	0.1	-2.0	-0.9	0.7	-0.5	-0.6
Fe content in liver	2.0	2.4	3.9	-0.3	0.2	-1.7	-2.0	1.8	-1.9	-1.8
K content in liver	0.1	0.0	0.3	0.0	0.0	0.6	0.2	-0.0	-0.0	0.0
Mg content in liver	0.3	0.3	0.7	0.8	-0.8	-0.4	-0.2	0.3	-0.4	-0.2
Mn content in liver	0.7	0.8	2.3	1.5	-1.5	-1.0	0.1	0.0	0.0	0.0
Na content in liver	1.0	1.0	1.7	-0.3	0.4	0.6	1.3	-1.2	1.3	1.3
Rb content in liver	0.9	1.1	1.6	1.3	-1.3	0.5	0.8	-1.0	1.1	1.1
Se content in liver	0.6	0.7	2.0	1.1	-1.0	1.4	0.5	-0.5	0.3	0.3
Sr content in liver	1.7	1.5	2.6	0.5	-0.6	-0.9	-1.4	1.5	-1.6	-1.6
Zn content in liver	0.9	1.0	1.5	1.2	-1.2	1.0	1.1	-0.8	0.6	0.8
Bone: minimum diameter	0.5	0.9	1.5	-0.8	0.8	-0.1	-1.1	1.0	-1.2	-0.9
Time in familiar zone, hab. session 1	0.6	0.6	1.1	1.0	-1.0	-0.1	0.7	-0.7	0.6	0.7
Time in novel zone, hab. session 1	1.2	1.2	3.2	-0.5	0.5	1.8	1.1	-1.0	1.0	1.0
Total zone transitions, hab. session 1	3.6	5.0	11.7	0.4	-0.5	-3.4	-2.5	2.5	-2.3	-2.3
Total locomotion distance, hab. session 1	1.1	1.5	1.9	1.2	-1.3	-1.4	-1.2	1.2	-1.1	-1.2
Locomotion velocity, hab. session 1	2.0	2.9	4.0	0.8	-0.9	-2.0	-1.9	1.9	-1.8	-1.9
Time in familiar zone, hab. session 2	1.0	1.0	1.8	0.3	-0.3	0.7	1.3	-1.3	1.3	1.2
Time in novel zone, hab. session 2	0.3	0.3	0.6	0.2	-0.2	0.3	-0.6	0.7	-0.8	-0.7
Total zone transitions, hab. session 2	0.7	0.9	2.9	0.2	-0.3	-1.7	-0.9	0.9	-0.8	-0.8
Total locomotion distance, hab. session 2	0.0	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1	-0.1	-0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.1	0.1	-0.3	-0.5	0.5	-0.4	-0.5
Novel to familiar place preference ratio	1.8	1.9	2.9	-0.6	0.5	-1.3	-1.6	1.6	-1.7	-1.7
Novelty place preference	1.7	1.7	2.9	-0.3	0.2	-1.1	-1.6	1.6	-1.7	-1.6
Time in novel zone, NPP test	1.0	1.0	1.9	0.1	-0.1	-0.7	-1.2	1.3	-1.4	-1.3
Total zone transitions, NPP test	1.6	2.3	4.0	1.0	-1.1	-2.0	-1.6	1.7	-1.5	-1.6
Total locomotion distance, NPP test	0.4	0.6	0.9	0.9	-1.0	-0.7	-0.6	0.7	-0.6	-0.7
Locomotion velocity, NPP test	0.9	1.3	1.9	0.6	-0.6	-1.3	-1.3	1.4	-1.2	-1.3
Intraocular pressure	1.3	1.9	3.2	-0.3	0.3	-1.4	-1.6	1.6	-1.6	-1.8
Delta distance traveled before/after self-admin	1.9	2.1	4.9	-2.2	2.2	0.3	1.3	-1.0	1.0	1.1
Delta ambulatory time before/after self-admin	1.4	1.5	2.7	-1.6	1.6	0.9	1.2	-1.0	0.9	1.1
Parametrial fat weight	0.3	0.5	2.0	0.8	-0.8	1.4	0.2	-0.4	0.2	0.3
Pavlov. Cond. lever latency	1.5	1.9	6.5	-2.6	2.6	-0.4	-0.1	0.1	-0.1	-0.1
Pavlov. Cond. magazine entry latency	3.3	4.2	8.7	2.9	-2.9	2.7	1.3	-1.3	0.9	1.0
Pavlov. Cond. change in total contacts	2.7	2.9	9.6	3.1	-3.1	1.0	0.5	-0.4	0.2	0.2
Pavlov. Cond. index score	3.0	3.9	10.2	3.2	-3.1	1.8	1.0	-1.0	0.8	0.9
Pavlov. Cond. latency score	2.4	3.0	8.6	2.9	-2.9	1.5	0.7	-0.7	0.5	0.6
Pavlov. Cond. lever contacts	1.4	1.7	5.9	2.4	-2.4	0.1	0.1	-0.1	0.1	0.1
Pavlov. Cond. magazine entry number	4.5	5.6	11.7	-3.4	3.4	-2.4	-1.7	1.7	-1.4	-1.5
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.2	-0.8	0.7	-1.5	-1.1	1.1	-0.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.2	10.9	3.3	-3.2	2.1	1.0	-1.0	0.8	0.9
Pavlov. Cond. response bias	3.5	4.2	10.7	3.3	-3.2	1.9	1.2	-1.2	1.0	1.1
Pavlov. Cond. lever latency	0.4	0.5	1.0	0.0	-0.0	-0.9	-0.8	0.9	-1.0	-0.7
Pavlov. Cond. magazine entry latency	0.7	0.8	1.6	0.4	-0.4	-0.4	-1.0	1.1	-1.1	-1.3
Pavlov. Cond. change in total contacts	0.3	0.4	0.9	0.4	-0.4	1.0	0.6	-0.7	0.7	0.4
Pavlov. Cond. index score	0.1	0.1	0.7	0.1	-0.0	0.8	0.1	-0.1	0.2	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.4	0.1	-0.1	0.7	-0.3	0.2	-0.1	-0.4
Pavlov. Cond. lever contacts	0.5	0.7	1.6	0.5	-0.4	1.3	0.9	-0.9	1.0	0.6
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	-0.3	0.3	-0.6	0.6	-0.5	0.4	0.7
Pavlov. Cond. intertrial magazine entries	0.9	1.1	5.2	-0.1	0.1	-2.3	-0.9	0.9	-0.9	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.6	-0.1	0.1	0.8	0.0	-0.1	0.2	-0.2
Pavlov. Cond. response bias	0.4	0.6	2.0	0.5	-0.5	1.4	0.7	-0.7	0.8	0.4
Time in closed arm before self-admin	0.8	0.9	1.8	0.7	-0.7	1.3	0.7	-0.9	0.9	1.0
Time in closed arm after self-admin	0.4	0.5	1.5	-1.2	1.2	-0.2	-0.3	0.0	0.2	0.1
Time in open arm before self-admin	0.9	1.0	2.4	-1.5	1.5	-1.5	0.0	0.3	-0.1	-0.3
Time in open arm after self-admin	0.3	0.3	1.4	-0.1	0.1	-1.2	0.7	-0.4	0.4	0.4
Bone: periosteal estimation	0.2	0.5	1.2	-1.1	1.1	0.5	-0.5	0.3	-0.5	-0.2
Bone: periosteal perimeter	0.3	0.6	1.7	-1.3	1.3	-0.1	-0.6	0.4	-0.4	-0.3
Bone: post-yield work	0.5	0.6	1.8	-1.3	1.3	-0.2	-0.5	0.4	-0.5	-0.4
Progressive ratio test 1 active lever presses	0.4	0.5	1.1	0.9	-0.9	1.1	-0.1	0.3	-0.4	-0.5
Progressive ratio test 1 breakpoint	0.7	0.7	1.4	1.2	-1.2	1.0	-0.3	0.5	-0.6	-0.7
Progressive ratio test 1 inactive lever presses	0.5	0.6	1.3	0.9	-0.9	1.1	0.4	-0.6	0.6	0.4
Progressive ratio test 2 active lever presses	0.5	0.5	1.0	1.0	-1.0	0.8	0.5	-0.5	0.4	0.3
Progressive ratio test 2 breakpoint	0.4	0.5	0.9	1.0	-0.9	0.8	0.4	-0.5	0.4	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	0.3	-0.3	-0.3	0.5	-0.4	0.5	0.4
Incentive Sensitization - Responses	0.5	0.5	0.7	0.8	-0.8	0.8	0.5	-0.7	0.6	0.6
Incentive Sensitization - Breakpoint	0.4	0.4	0.8	0.6	-0.6	0.9	0.5	-0.7	0.6	0.6
Sum of active levers in priming session hrs 5-6	1.3	1.3	2.4	1.5	-1.5	-0.6	-0.8	1.0	-1.1	-1.1
Progressive ratio	0.2	0.2	0.3	0.5	-0.6	-0.5	-0.4	0.5	-0.4	-0.5
Food seeking constrained by brief footshock	0.3	0.4	1.2	0.0	0.0	1.1	0.8	-0.7	0.5	0.6
Seeking ratio, punishment vs. effort	0.3	0.3	1.2	-0.2	0.3	1.1	0.5	-0.6	0.3	0.4
Retroperitoneal fat weight	0.3	1.0	1.8	-0.6	0.6	1.2	-1.4	0.9	-1.1	-0.9
Reaction time number correct	0.3	0.4	1.4	-0.3	0.3	-1.2	-0.5	0.6	-0.4	-0.4
Reaction time mean minus median	0.1	0.2	0.4	-0.0	0.0	-0.6	0.4	-0.5	0.5	0.5
Reaction time mean minus median AUC	0.5	0.6	0.8	0.8	-0.8	-0.2	0.9	-0.9	0.9	0.8
Reaction time num false alarms	0.5	0.7	2.1	1.4	-1.4	0.4	0.5	-0.0	-0.3	0.2
Reaction time num false alarms AUC	0.4	0.6	1.9	1.4	-1.4	0.3	0.3	0.2	-0.5	-0.0
Reaction time trials correct on left	0.3	0.4	1.4	-0.3	0.3	-1.2	-0.5	0.6	-0.4	-0.4
Reaction time trials on left	0.2	0.3	1.4	-0.3	0.2	-1.2	-0.5	0.6	-0.4	-0.4
Reaction time mean	0.7	1.0	1.7	-0.5	0.6	-0.1	1.2	-1.3	1.3	1.3
Reaction time mean AUC	0.6	0.9	1.5	-0.5	0.5	-0.1	1.1	-1.2	1.2	1.2
Median of all reaction times	1.1	1.5	2.6	-0.4	0.4	0.4	1.5	-1.6	1.5	1.6
Reaction time omissions	0.2	0.3	0.8	0.6	-0.6	0.9	0.4	-0.5	0.4	0.3
Reaction time false alarm rate	0.5	0.7	1.7	1.3	-1.3	1.0	0.6	-0.2	-0.1	0.2
Reaction time premature initiation rate	0.3	0.4	0.6	0.8	-0.8	0.3	-0.5	0.6	-0.6	-0.6
Reaction time premature initiations	0.4	0.5	0.9	0.5	-0.5	-0.6	-0.8	1.0	-0.9	-0.8
Std. dev. reaction times	0.1	0.1	0.2	0.0	-0.0	-0.2	0.4	-0.5	0.4	0.4
Reaction time trials completed	0.2	0.3	1.4	-0.3	0.2	-1.2	-0.5	0.6	-0.4	-0.4
Reaction time trials AUC	0.2	0.3	1.3	-0.2	0.1	-1.1	-0.4	0.5	-0.4	-0.3
Run reversals in cocaine runway, females	1.5	1.5	1.9	-1.2	1.2	-0.8	-1.3	1.3	-1.4	-1.3
Run reversals in cocaine runway, males	2.9	2.8	5.5	0.1	-0.1	0.5	1.9	-2.2	2.3	2.4
Latency to leave start box in cocaine runway	1.7	1.9	5.6	-2.4	2.4	-0.4	0.8	-0.5	0.5	0.8
Latency to leave start box in cocaine runway, F	2.1	2.2	6.9	-2.6	2.6	0.1	0.8	-0.5	0.7	0.8
Latency to leave start box in cocaine runway, M	0.4	0.4	0.8	-0.9	0.9	-0.1	0.5	-0.6	0.4	0.5
Std. dev. time between licks in bursts	0.8	1.0	1.7	-1.3	1.3	0.2	0.9	-0.9	0.9	1.0
Total sessions with >9 infusions	0.4	0.4	2.2	0.3	-0.3	1.5	0.4	-0.5	0.5	0.3
Short access day 1 total inactive lever presses	1.9	2.2	7.4	2.7	-2.7	-0.4	-0.5	0.1	-0.1	-0.2
Short access day 10 total inactive lever presses	0.4	0.4	2.2	0.4	-0.5	-1.5	-0.2	-0.0	0.2	0.1
Short access day 1 total infusions	0.1	0.1	0.3	0.3	-0.3	0.2	0.2	-0.4	0.5	0.4
Short access day 10 total infusions	0.2	0.2	0.6	-0.2	0.3	0.8	0.4	-0.4	0.4	0.3
Short access total infusions	0.0	0.0	0.0	-0.2	0.2	0.2	-0.0	-0.0	0.0	-0.1
Short access day 1 locomotion	0.9	0.9	3.1	0.6	-0.6	1.8	0.5	-0.9	1.0	0.7
Short access day 10 total locomotion	0.8	0.9	2.7	1.0	-1.0	1.6	1.0	-0.5	0.4	0.3
Short access total locomotion	0.4	0.4	1.9	0.3	-0.2	1.4	0.6	-0.4	0.4	0.3
One hour access (0.3 mA shock)	0.2	0.2	0.6	0.8	-0.8	-0.3	-0.2	0.1	-0.2	-0.1
Compulsive drug intake	3.1	3.2	4.7	1.5	-1.6	-1.7	-2.2	1.8	-1.8	-1.8
One hour access (shock baseline)	1.4	1.7	2.4	-0.5	0.6	1.5	1.5	-1.5	1.4	1.5
Social response proportion	1.3	1.4	2.9	0.8	-0.8	0.1	-1.2	1.4	-1.7	-1.5
Social responses	0.1	0.1	0.4	0.4	-0.4	0.4	-0.1	0.3	-0.6	-0.3
Social time	0.4	0.6	1.3	-0.2	0.2	-0.3	1.1	-0.9	0.8	1.1
Soleus weight	0.4	1.1	5.1	0.1	0.0	2.3	0.7	-0.8	0.8	0.8
Bone: stiffness	0.1	0.2	0.5	-0.0	0.0	0.7	-0.4	0.4	-0.6	-0.3
Tibialis anterior weight	0.6	2.1	4.7	-1.1	1.0	-2.2	-1.7	1.4	-1.2	-1.3
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.8	0.9	-0.9	-0.8	-0.4	0.3	-0.6	-0.3
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.6	-0.3	0.3	0.1	0.8	-0.5	0.8	0.5
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.6	0.6	-0.6	-0.2	-0.1	0.1	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.4	0.4	0.4	-0.4	0.2	-0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.2	-0.2	0.3	1.1	0.9	-0.9	1.1	0.7
Delta time to tail flick, test, before/after SA	0.8	0.7	0.9	1.0	-0.9	1.0	-0.8	0.7	-0.7	-0.8
Tibia length	0.5	1.4	3.4	-1.8	1.8	-0.1	-1.1	0.8	-0.8	-0.8
Ambulatory time before self-admin	0.3	0.3	0.5	0.2	-0.2	-0.6	-0.6	0.7	-0.6	-0.7
Ambulatory time after self-admin	1.7	1.8	6.4	-2.5	2.5	0.0	0.2	0.3	-0.2	-0.2
Bone: tissue strength	0.3	0.3	0.8	-0.9	0.9	-0.4	0.2	-0.2	0.2	0.2
Total heroin consumption	0.4	0.5	1.3	1.1	-1.1	-0.8	-0.2	0.1	-0.0	-0.2
Bone: trabecular number	1.9	3.0	6.3	1.5	-1.4	2.5	1.5	-1.8	1.6	1.6
Bone: trabecular spacing	0.2	0.3	1.0	-0.5	0.5	-1.0	0.4	-0.1	0.2	0.2
Bone: trabecular thickness	0.4	0.5	1.5	-1.0	1.0	1.2	-0.2	-0.0	-0.1	0.0
Bone: trabecular tissue density	0.1	0.1	0.4	0.6	-0.6	-0.2	-0.2	0.3	-0.2	-0.3
Water consumed over 24 hours	0.0	0.1	0.3	0.2	-0.2	-0.5	-0.0	-0.1	0.2	0.0
Number of responses in last shaping day	0.3	0.3	0.7	-0.3	0.3	-0.4	0.8	-0.5	0.7	0.5