Hub : Genes

Tbcd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio XM_006247864.4 0.08 0.04 7.2e-09 0.08 0.08 0.08 0.08 2.0e-09 7.2e-10 1.9e-09 2.2e-09
2 BLA isoform ratio XM_006247864.4 0.17 0.08 1.8e-06 0.12 0.12 0.11 0.05 7.2e-07 4.3e-07 2.1e-06 1.5e-03
3 Brain mRNA stability Tbcd 0.03 0.02 7.3e-03 -0 0 -0 -0 6.6e-01 1.6e-01 6.6e-01 8.8e-01
4 Brain intron excision ratio chr10_106868314_106868880 0.05 0.03 1.8e-05 0.05 0.06 0.03 0.05 8.9e-06 4.7e-06 1.4e-03 1.6e-05
5 PL mRNA stability Tbcd 0.03 0.02 2.2e-04 0.04 0.04 0.04 0.04 1.3e-05 8.5e-05 6.8e-05 3.2e-05
6 BLA isoform ratio NM_001271364.2 0.2 0.06 1.8e-11 0.22 0.21 0.2 0.22 5.3e-12 1.7e-11 3.5e-11 6.9e-12
7 pVTA isoform ratio XM_006247864.4 0.13 0.06 1.6e-05 0.11 0.13 0.15 0.12 1.4e-05 2.9e-06 7.3e-07 1.0e-05
8 Brain isoform ratio NM_001271364.2 0.14 0.05 0.0e+00 0.2 0.2 0.21 0.19 1.3e-18 1.1e-18 7.4e-19 1.1e-17
9 Adipose mRNA stability Tbcd 0.15 0.07 9.4e-10 0.08 0.08 0.07 0 1.7e-09 6.3e-09 2.1e-08 3.0e-01
10 PL isoform ratio XM_006247864.4 0.08 0.04 2.1e-09 0.09 0.09 0.09 0.09 2.7e-10 4.9e-10 5.6e-10 4.1e-10
11 BLA mRNA stability Tbcd 0.08 0.05 3.8e-04 0.07 0.05 0.04 0.03 1.3e-04 9.1e-04 2.7e-03 1.6e-02
12 PL gene expression Tbcd 0.06 0.03 4.7e-07 0.08 0.06 0.06 0.07 5.5e-09 4.6e-07 8.6e-07 3.5e-08
13 Brain isoform ratio XM_006247864.4 0.1 0.04 8.9e-14 0.14 0.16 0.15 0.15 7.4e-13 1.0e-14 4.3e-14 4.8e-14
14 PL isoform ratio NM_001271364.2 0.16 0.07 0.0e+00 0.2 0.17 0.19 0.2 7.8e-22 3.7e-18 3.9e-20 5.1e-21
15 PL intron excision ratio chr10_106868989_106870530 0.04 0.02 1.4e-06 0.07 0.06 0.06 0.06 4.9e-08 1.7e-07 2.2e-07 1.3e-07
16 Adipose gene expression Tbcd 0.47 0.1 0.0e+00 0.36 0.36 0.38 0.12 1.1e-41 9.1e-42 4.3e-45 7.8e-13
17 NAcc isoform ratio NM_001271364.2 0.1 0.04 2.8e-16 0.15 0.15 0.14 0.15 2.4e-17 3.6e-17 6.3e-16 1.6e-16
18 pVTA isoform ratio NM_001271364.2 0.17 0.08 2.7e-07 0.18 0.15 0.13 0.16 1.9e-08 7.2e-07 3.3e-06 1.9e-07
19 OFC isoform ratio NM_001271364.2 0.29 0.15 9.4e-04 0.13 0.02 0.09 0.12 4.8e-04 1.2e-01 3.1e-03 1.0e-03
20 Liver gene expression Tbcd 0.15 0.06 0.0e+00 0.15 0.14 0.14 0.14 5.3e-16 9.9e-16 5.4e-15 1.1e-15
21 NAcc gene expression Tbcd 0.09 0.04 1.0e-08 0.06 0.08 0.06 0.05 4.2e-07 2.4e-09 7.1e-08 7.3e-07
22 pVTA intron excision ratio chr10_106868989_106870530 0.2 0.11 7.1e-06 0.07 0.14 0.15 0.1 7.5e-04 1.3e-06 3.3e-07 4.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.30.52.1-1.0-0.70.60.5-0.5-0.60.8-0.70.60.6-0.60.7-0.5-0.7-0.61.0-0.8-0.8-0.40.9-0.6-1.4
Area under the delay curve2.32.43.51.51.9-1.4-1.61.71.7-1.91.5-1.7-1.61.6-1.61.61.51.5-1.31.31.31.4-1.21.81.1
BMI with tail0.61.85.0-2.0-2.11.61.7-1.4-1.41.5-1.11.31.2-1.31.2-1.3-1.2-1.21.0-0.9-0.92.20.5-0.60.3
BMI without tail5.110.521.4-4.0-3.34.62.9-3.4-3.42.2-3.43.33.3-3.33.3-3.6-3.3-3.22.6-3.0-3.0-2.62.8-3.6-2.2
Body weight2.711.518.3-4.3-4.04.14.0-3.8-3.73.3-3.83.63.6-3.53.5-3.7-3.5-3.53.3-2.9-2.90.92.8-2.0-1.9
Weight adjusted by age2.93.35.7-1.7-2.21.52.0-2.3-2.02.4-2.12.32.2-1.81.8-1.8-1.4-1.51.8-1.4-1.4-0.81.3-1.3-2.1
Bone surface0.61.02.9-1.0-0.80.90.7-0.9-0.81.0-1.10.90.9-0.80.9-0.9-0.8-0.81.1-1.1-1.1-1.21.2-0.9-1.7
Bone volume0.50.82.2-1.0-0.80.80.7-0.8-0.70.9-0.90.80.8-0.80.8-0.8-0.8-0.71.0-1.0-1.0-1.11.0-1.0-1.5
Breakpoint value in progressive ratio session1.01.12.31.11.2-0.3-0.40.81.2-0.80.5-1.1-1.11.4-1.40.41.41.4-1.11.01.00.5-1.01.50.8
Number of licking bursts0.30.30.7-0.7-0.50.50.3-0.7-0.60.3-0.50.70.7-0.60.6-0.4-0.6-0.60.5-0.8-0.8-0.40.7-0.8-0.4
Context. condit. distance diff. score0.70.92.0-1.4-0.91.40.5-0.9-0.90.4-1.10.90.9-0.90.9-0.9-0.9-0.90.7-0.9-0.9-0.81.0-1.3-1.0
Locomotion velocity, session 11.81.94.21.91.1-2.0-1.01.61.5-0.71.4-1.5-1.51.4-1.41.41.41.4-1.21.11.10.9-1.31.31.7
Locomotion distance, session 11.11.43.70.70.9-1.1-1.51.11.1-1.31.4-1.2-1.21.2-1.21.51.21.2-1.11.01.01.9-1.11.00.3
Locomotion velocity, session 24.75.56.52.42.4-2.4-2.42.42.4-2.42.6-2.4-2.42.3-2.32.52.32.3-2.42.22.22.1-2.42.42.0
Locomotion distance, session 20.10.21.8-0.20.20.0-0.60.20.2-0.90.4-0.2-0.20.0-0.10.60.10.0-0.2-0.1-0.11.3-0.20.50.1
Locomotion velocity, session 33.03.55.92.12.0-2.2-1.71.91.9-1.91.7-1.9-1.91.8-1.92.01.91.8-1.51.81.81.8-1.72.41.1
Locomotion distance, session 35.05.57.42.32.5-2.4-2.32.42.3-2.52.2-2.4-2.42.3-2.42.52.42.3-2.12.42.42.6-2.32.71.4
Stereotopy head waving bouts, day 30.20.20.60.60.2-0.8-0.30.40.4-0.10.5-0.4-0.40.5-0.50.60.50.5-0.30.40.40.7-0.30.60.4
Stereotopy head waving duration, day 30.00.00.40.1-0.2-0.3-0.1-0.00.0-0.10.2-0.00.00.1-0.10.30.10.1-0.00.20.20.6-0.00.30.1
Locomotion velocity, session 71.01.11.60.91.2-0.9-1.21.21.2-1.11.0-1.1-1.11.1-1.11.11.11.1-1.01.21.20.7-0.90.90.4
Locomotion distance, session 73.13.96.11.62.2-1.6-2.32.12.0-2.52.0-2.1-2.01.9-1.92.11.91.9-2.12.22.21.6-1.91.51.3
Stereotopy head waving bouts, day 70.50.61.2-0.9-1.10.90.7-0.9-0.80.7-0.70.90.9-0.70.7-0.7-0.7-0.70.7-0.7-0.70.20.7-0.6-0.5
Stereotopy head waving duration, day 70.70.81.2-1.0-1.10.90.9-1.1-1.00.9-0.91.01.0-0.90.9-0.8-0.9-0.90.9-0.9-0.9-0.10.9-0.6-0.9
Locomotion velocity, session 80.20.21.9-0.40.3-0.2-0.50.40.3-0.60.3-0.4-0.40.2-0.20.60.20.2-0.00.20.21.4-0.20.6-0.6
Locomotion distance, session 80.60.92.9-1.7-0.91.60.1-0.9-0.9-0.3-0.90.90.9-1.00.9-0.5-0.9-1.00.7-1.0-1.00.50.9-0.9-1.3
Degree of sensitization distance0.90.92.5-1.0-0.81.20.6-0.8-0.80.7-0.80.80.8-1.01.0-1.0-1.0-1.00.7-0.8-0.8-1.60.9-1.5-0.6
Degree of sensitization stereotypy0.60.61.1-1.0-1.01.00.8-0.9-0.90.6-0.80.90.9-0.70.8-0.8-0.8-0.70.7-0.7-0.70.10.7-0.6-0.5
Conditioned locomotion5.66.58.6-2.9-2.52.92.3-2.7-2.62.1-2.62.62.6-2.62.6-2.6-2.6-2.62.5-2.7-2.7-1.82.5-2.5-2.3
Cocaine response after cond. corrected0.50.50.90.80.9-0.8-0.40.80.8-0.40.5-0.8-0.80.7-0.70.50.70.7-0.60.80.80.6-0.60.90.9
Cocaine response after cond. not corrected1.21.31.81.21.3-1.1-0.91.21.2-1.01.0-1.2-1.21.2-1.21.01.21.2-1.11.21.20.8-1.11.21.0
Cocaine response before conditioning0.60.71.70.60.9-0.5-1.20.70.8-1.31.1-0.7-0.70.7-0.71.10.80.7-1.00.80.80.7-0.90.70.2
Saline control response2.33.03.9-1.7-1.31.61.7-1.7-1.81.3-1.81.71.7-2.02.0-1.8-1.9-1.92.0-2.0-2.0-1.61.8-1.3-1.3
Bone: connectivity density0.20.32.2-0.7-0.20.3-0.1-0.2-0.30.2-0.30.30.2-0.40.4-0.1-0.5-0.40.7-0.6-0.6-0.60.7-0.5-1.5
Bone: cortical apparent density3.14.06.02.32.1-2.4-1.92.12.0-2.12.0-2.1-2.12.0-2.02.12.02.0-1.91.91.91.2-1.91.91.8
Bone: cortical area6.39.415.3-3.7-3.92.93.7-3.4-3.33.4-3.23.23.2-3.23.2-2.8-3.2-3.23.4-2.8-2.82.22.5-0.9-2.1
Bone: cortical porosity0.10.20.80.4-0.50.10.9-0.4-0.30.9-0.40.40.4-0.10.1-0.6-0.1-0.10.20.10.1-0.1-0.00.20.6
Bone: cortical porosity0.40.41.4-0.1-0.90.41.1-0.8-0.61.2-0.70.70.7-0.50.4-0.9-0.4-0.50.5-0.3-0.3-0.50.4-0.20.0
Bone: cortical thickness5.08.314.6-3.2-3.82.03.8-3.1-3.13.4-2.82.92.9-3.03.0-2.5-3.0-3.03.4-2.5-2.53.32.2-0.2-0.8
Bone: cortical thickness2.02.35.5-1.6-2.20.92.1-1.6-1.61.9-1.21.51.5-1.51.6-1.2-1.6-1.51.6-1.3-1.32.41.0-0.10.5
Bone: cortical tissue density3.54.66.82.52.3-2.6-2.12.32.2-2.22.2-2.2-2.22.2-2.22.32.22.2-2.12.02.01.0-2.01.91.9
Condit. Reinf. active minus inactive responses2.52.83.8-1.8-1.71.81.7-1.7-1.71.6-1.91.71.7-1.71.7-1.8-1.7-1.71.8-1.6-1.6-1.31.7-1.4-1.5
Condit. Reinf. active-inactive response ratio1.01.13.0-1.3-1.00.91.1-0.9-1.00.9-1.31.01.0-1.01.0-1.0-1.0-1.01.4-1.0-1.0-0.31.1-0.4-1.7
Condit. Reinf. active responses4.55.56.7-2.5-2.42.62.3-2.4-2.42.2-2.62.42.4-2.42.4-2.5-2.4-2.42.2-2.2-2.2-2.02.4-2.4-1.5
Condit. Reinf. inactive responses1.21.42.8-1.1-1.11.41.1-1.2-1.21.2-1.21.21.2-1.21.2-1.4-1.1-1.10.9-1.2-1.2-1.61.2-1.70.1
Incentive salience index mean1.92.23.0-1.7-1.51.71.4-1.5-1.51.3-1.71.51.5-1.51.5-1.6-1.5-1.51.5-1.4-1.4-1.31.5-1.5-1.4
Condit. Reinf. lever presses0.00.10.4-0.10.10.4-0.30.00.1-0.20.1-0.0-0.00.1-0.1-0.00.10.1-0.30.30.3-0.6-0.0-0.5-0.0
Condit. Reinf. active minus inactive responses1.92.44.2-2.0-1.71.51.6-1.5-1.61.7-1.71.51.4-1.51.5-1.5-1.5-1.61.8-1.5-1.5-0.11.4-0.8-1.9
Condit. Reinf. active-inactive response ratio3.73.95.8-2.2-2.31.82.3-2.0-2.12.4-2.22.02.0-1.91.9-2.1-1.9-2.02.1-1.8-1.8-0.81.9-1.5-1.6
Condit. Reinf. active responses0.60.82.3-1.3-0.91.00.9-0.7-0.91.0-1.00.70.7-0.80.8-0.8-0.7-0.81.0-0.8-0.80.10.8-0.3-1.5
Condit. Reinf. inactive responses0.60.81.40.61.1-0.6-0.91.00.9-1.00.7-1.0-0.90.9-0.90.91.00.9-0.70.80.81.0-0.81.2-0.2
Condit. Reinf. lever presses0.20.30.7-0.8-0.40.80.4-0.5-0.60.1-0.60.50.5-0.60.6-0.5-0.6-0.60.6-0.8-0.8-0.30.7-0.5-0.6
Condit. Reinf. lever reinforcers received0.50.72.2-1.4-0.91.10.8-0.7-0.80.9-1.00.70.7-0.80.8-0.8-0.7-0.80.9-0.8-0.80.10.8-0.4-1.5
Conditioned reinforcement - actives0.10.10.3-0.3-0.10.2-0.1-0.3-0.1-0.30.10.10.3-0.30.3-0.0-0.5-0.40.1-0.5-0.5-0.20.3-0.5-0.1
Conditioned reinforcement - inactives0.10.10.4-0.00.20.60.5-0.4-0.5-0.3-0.60.30.3-0.20.2-0.5-0.2-0.30.1-0.3-0.3-0.60.20.10.6
Conditioned locomotion0.10.10.50.10.20.3-0.30.00.4-0.70.2-0.4-0.2-0.30.30.1-0.3-0.3-0.1-0.2-0.2-0.40.40.1-0.3
Patch foraging indifference point 0 sec0.00.10.30.10.4-0.1-0.10.20.1-0.1-0.2-0.2-0.20.1-0.00.00.30.20.10.20.2-0.50.00.2-0.5
Patch foraging indifference point AUC0.20.31.3-0.2-0.60.40.3-0.4-0.40.3-0.20.40.3-0.40.2-0.4-0.6-0.50.2-0.8-0.8-1.10.5-0.90.0
Delay disc. indifference point, 0s delay0.10.11.5-0.10.0-0.4-0.0-0.30.00.4-0.00.20.30.1-0.00.30.00.00.10.40.41.2-0.30.60.1
Delay disc. indifference point, 16s delay1.81.84.71.11.8-0.9-1.81.41.2-2.21.4-1.2-1.11.4-1.41.61.41.5-1.41.11.11.2-1.11.30.5
Delay disc. indifference point, 2s delay0.60.71.10.80.7-0.7-0.70.70.9-0.60.7-0.9-0.80.8-0.80.70.70.7-0.81.11.10.8-0.91.00.8
Delay disc. indifference point, 24s delay6.05.87.52.72.6-2.5-2.42.62.7-2.62.4-2.7-2.72.6-2.62.52.42.6-2.12.02.01.8-2.02.71.1
Delay disc. indifference point, 4s delay0.70.71.80.71.1-1.2-0.71.30.8-0.90.8-0.8-0.90.6-0.61.00.50.5-0.30.60.61.2-0.51.30.4
Delay disc. indifference point, 8s delay1.51.52.71.31.5-1.4-0.91.21.3-1.21.0-1.2-1.21.3-1.31.11.31.3-0.91.11.11.3-1.11.61.2
Indifference point function ln k0.91.36.30.61.0-1.2-1.10.90.8-1.01.1-0.9-0.80.9-0.71.31.00.9-0.71.51.52.5-1.11.50.3
Indifference point function log k0.91.36.30.61.0-1.2-1.10.90.8-1.01.1-0.9-0.80.9-0.71.31.00.9-0.71.51.52.5-1.11.50.3
Patch foraging total patch changes 0 sec0.00.00.30.00.4-0.1-0.10.20.1-0.1-0.2-0.2-0.10.10.00.00.30.10.10.10.1-0.40.10.2-0.6
Patch foraging total patch changes 12 sec0.10.11.00.40.1-0.10.10.20.20.1-0.0-0.2-0.20.1-0.2-0.20.10.1-0.2-0.1-0.1-1.0-0.0-0.30.4
Patch foraging total patch changes 18 sec0.10.10.60.10.4-0.1-0.40.40.3-0.50.1-0.3-0.30.3-0.30.20.20.2-0.20.10.1-0.8-0.10.1-0.8
Patch foraging total patch changes 24 sec0.20.20.9-0.4-0.30.40.5-0.2-0.30.3-0.60.30.2-0.50.4-0.5-0.4-0.40.5-0.7-0.7-1.00.5-0.3-0.6
Patch foraging total patch changes 6 sec0.30.51.7-0.4-0.60.50.7-0.6-0.60.7-0.60.60.5-0.60.6-0.7-0.7-0.60.7-0.9-0.9-1.30.8-0.7-0.1
Patch foraging time to switch 0 sec0.40.60.90.80.7-0.6-0.90.80.8-0.50.6-0.8-0.60.8-0.90.70.90.9-0.90.90.90.1-0.60.30.7
Patch foraging water rate 0 sec0.61.01.6-1.1-0.51.31.1-0.9-1.00.3-1.20.90.9-1.11.2-1.2-1.1-1.01.1-1.0-1.0-0.70.9-0.4-1.1
Patch foraging water rate 12 sec0.10.21.6-0.6-0.40.30.4-0.3-0.30.0-0.30.20.3-0.40.4-0.2-0.2-0.30.2-0.0-0.01.30.00.30.3
Patch foraging water rate 18 sec0.50.71.8-1.3-0.81.00.6-0.8-0.90.3-0.80.80.8-0.90.9-0.6-0.8-1.00.9-0.7-0.70.50.7-0.3-1.3
Patch foraging water rate 24 sec1.01.35.4-1.7-1.01.61.0-1.0-1.10.3-1.41.01.1-1.11.2-1.0-1.1-1.11.2-0.8-0.80.11.0-0.3-2.3
Patch foraging water rate 6 sec0.30.45.10.00.3-0.2-0.20.30.3-0.70.1-0.4-0.20.3-0.20.50.40.4-0.30.70.72.3-0.61.30.3
Seeking ratio, delayed vs. immediate footshock1.61.82.6-1.5-1.21.21.4-1.0-1.31.4-1.31.21.0-1.51.4-1.4-1.4-1.61.6-1.5-1.5-0.81.4-1.2-1.2
Distance traveled before self-admin0.30.31.30.0-0.10.10.7-0.2-0.20.1-0.70.30.2-0.60.6-0.5-0.7-0.50.9-0.6-0.6-0.70.70.5-1.2
Distance traveled after self-admin0.50.54.9-0.20.10.90.1-0.4-0.2-0.5-0.50.40.3-0.60.5-0.6-0.6-0.60.3-0.7-0.7-2.20.7-1.0-1.0
Extensor digitorum longus weight0.31.13.4-1.8-1.41.60.6-1.2-1.00.9-0.81.11.1-1.01.0-0.9-1.0-1.00.7-0.5-0.50.10.8-1.6-1.2
Bone: elastic displacement1.21.42.4-1.1-1.40.81.4-1.3-1.41.0-1.21.31.3-1.41.4-1.1-1.4-1.41.5-0.9-0.9-0.11.1-0.6-0.8
Bone: elastic work6.07.813.9-2.6-3.42.03.7-3.0-3.03.6-3.02.93.0-3.03.0-2.9-3.0-3.03.4-2.4-2.40.12.5-1.4-1.4
Bone: endosteal estimation0.10.32.6-0.7-0.21.2-0.3-0.2-0.1-0.1-0.30.20.20.1-0.0-0.30.10.1-0.20.00.0-0.90.0-0.7-1.6
Bone: endosteal perimeter0.81.66.4-1.4-1.11.51.0-1.2-1.11.4-1.41.11.2-1.01.0-1.3-1.0-1.01.2-1.0-1.0-1.51.1-1.0-2.5
Epididymis fat weight0.61.33.0-1.5-1.21.71.1-1.4-1.30.7-1.11.31.3-1.21.1-1.3-1.1-1.10.8-1.1-1.1-0.40.9-1.2-0.5
Delta time in closed arm before/after self-admin0.10.10.2-0.30.0-0.2-0.0-0.1-0.30.50.10.20.20.1-0.10.00.10.2-0.10.50.50.1-0.4-0.50.4
Delta time in open arm before/after self-admin0.40.41.20.70.6-0.3-0.50.70.9-1.10.4-0.7-0.80.5-0.50.50.50.4-0.70.50.5-0.4-0.70.50.2
Diff in mean of infusions in LGA sessions1.51.72.71.31.6-1.0-1.21.41.6-1.01.4-1.5-1.61.4-1.41.01.31.3-1.41.31.30.1-1.31.01.1
Delay discount exponential model param3.33.44.8-1.9-2.21.81.8-2.2-2.12.2-1.82.12.1-1.91.9-1.9-1.7-1.81.6-1.6-1.6-1.61.5-2.1-1.3
Extinction: sum of active levers before priming2.22.23.81.80.8-1.9-1.11.31.7-0.61.6-1.5-1.61.6-1.71.51.61.6-1.21.41.41.2-1.31.51.8
Active lever presses in extinction session 64.74.69.02.32.1-1.8-1.42.42.5-1.91.7-2.5-2.42.3-2.31.72.12.1-2.02.12.11.9-2.03.01.7
Bone: final force5.18.212.9-3.5-3.62.93.5-3.1-3.13.0-3.02.93.0-3.03.0-2.8-3.0-2.93.1-2.7-2.72.02.3-0.8-1.7
Bone: final moment5.89.514.9-3.7-3.93.13.8-3.3-3.33.4-3.33.13.2-3.23.2-3.0-3.2-3.13.4-2.9-2.91.82.5-1.1-1.9
Food consumed during 24 hour testing period0.50.61.2-0.8-0.60.70.7-0.7-0.70.9-0.80.70.7-0.80.8-0.8-0.8-0.70.8-1.0-1.0-1.01.0-1.10.3
Glucose3.95.810.43.22.1-2.9-1.52.32.4-1.32.2-2.3-2.22.6-2.62.12.62.5-2.32.72.71.7-2.52.92.5
Heart weight1.42.05.3-1.5-2.31.41.6-1.7-1.61.7-1.41.61.6-1.51.6-1.3-1.4-1.51.2-1.1-1.10.41.2-0.9-0.4
Delay discount hyperbolic model param3.03.24.4-1.8-2.11.81.7-2.1-2.02.0-1.82.02.0-1.81.8-1.9-1.6-1.71.5-1.5-1.5-1.61.4-2.1-1.3
Intermittent access intake day 1-15 change0.20.23.10.20.70.40.2-0.0-0.0-0.4-0.40.00.10.0-0.0-0.5-0.1-0.00.1-0.4-0.4-1.80.3-0.10.1
Intermittent access intake escalation0.30.33.20.20.80.6-0.00.10.1-0.7-0.3-0.2-0.10.0-0.0-0.4-0.00.0-0.1-0.5-0.5-1.80.4-0.10.3
Intermittent access intake escalation 20.20.22.50.50.40.50.50.00.1-0.3-0.5-0.2-0.1-0.00.0-0.6-0.1-0.0-0.0-0.3-0.3-1.60.20.30.1
Intermitt. access day 1 inactive lever presses0.10.10.6-0.20.10.50.6-0.4-0.30.0-0.60.20.1-0.20.2-0.6-0.2-0.20.00.10.1-0.6-0.30.00.8
Intermitt. access day 15 inactive lever presses0.60.61.2-0.8-0.21.00.4-0.7-0.9-0.2-1.10.70.7-0.80.8-0.6-0.7-0.80.9-1.1-1.1-0.80.9-0.1-1.1
Intermitt. access escalation Index1.71.53.2-1.6-1.11.20.8-1.1-1.01.1-1.11.01.1-1.01.0-1.2-1.2-1.01.2-1.4-1.4-1.41.3-1.8-1.4
Intermittent access day 1 total infusions0.80.91.3-1.1-1.01.10.9-1.1-1.00.9-0.90.81.0-1.11.1-0.9-1.1-1.10.9-1.1-1.1-0.11.1-1.0-0.3
Intermittent access day 15 total infusions0.50.51.5-0.7-0.21.00.5-0.5-0.50.2-0.80.30.5-0.60.6-0.8-0.7-0.70.5-1.1-1.1-1.21.0-0.8-0.1
Intermittent access terminal intake (last 3 days)0.60.72.5-0.6-0.31.00.7-0.6-0.60.4-0.90.40.5-0.70.7-1.0-0.8-0.70.6-1.1-1.1-1.61.1-0.9-0.2
Intermittent access total infusions0.60.71.2-0.9-0.41.00.6-0.7-0.80.4-0.80.60.7-0.90.9-0.8-1.0-1.00.8-1.1-1.1-0.61.1-0.8-0.2
Intermittent access day 1 locomotion0.10.10.2-0.40.20.50.1-0.20.1-0.5-0.2-0.2-0.1-0.30.3-0.1-0.3-0.3-0.0-0.1-0.10.5-0.00.20.2
Intermittent access day 15 total locomotion0.10.10.5-0.30.10.50.3-0.3-0.1-0.1-0.50.00.2-0.60.6-0.4-0.5-0.60.4-0.4-0.4-0.70.30.00.0
Intermittent access total locomotion0.10.10.4-0.20.40.50.1-0.10.2-0.6-0.3-0.2-0.1-0.30.3-0.2-0.2-0.3-0.0-0.1-0.10.1-0.10.40.4
Intermittent access standard deviation2.93.06.52.32.3-1.7-1.31.31.6-1.71.4-1.6-1.51.9-1.91.51.81.8-1.71.61.61.3-1.62.51.7
Left kidney weight0.20.74.1-1.0-1.50.51.0-0.9-0.71.4-0.80.70.7-0.40.5-0.5-0.4-0.40.60.00.02.00.20.3-0.5
Right kidney weight0.20.56.2-0.9-1.10.20.6-0.7-0.60.7-0.50.50.6-0.30.5-0.1-0.2-0.30.50.10.12.50.10.6-0.2
Cocaine induced anxiety0.60.73.1-0.2-0.60.41.8-0.4-0.51.7-1.10.60.7-0.50.5-1.3-0.5-0.50.9-0.6-0.6-0.20.70.30.4
Post-drug Anxiety0.30.31.50.70.6-0.60.30.60.70.1-0.0-0.5-0.40.5-0.50.00.50.5-0.30.60.60.5-0.61.20.4
Baseline Anxiety3.84.07.21.62.0-1.9-2.61.71.8-2.72.1-1.9-1.91.9-1.92.51.91.9-2.02.22.21.8-2.21.90.2
Tail length4.814.525.0-4.1-3.15.03.3-3.9-3.92.5-4.33.93.9-3.83.8-4.2-3.8-3.83.2-3.6-3.6-4.43.7-3.9-3.3
Length with tail1.55.78.3-2.7-2.32.82.7-2.8-2.62.3-2.92.72.7-2.42.5-2.7-2.5-2.42.3-2.0-2.0-0.62.2-1.5-1.7
Length without tail0.92.016.11.10.5-1.6-0.10.81.00.10.9-1.0-1.01.2-1.11.01.21.1-0.71.31.34.0-1.32.41.5
Times rat made contact with spout1.92.211.5-0.4-1.10.81.3-1.2-1.21.7-1.41.31.2-1.11.1-1.5-1.2-1.11.3-1.8-1.8-3.41.7-1.90.1
Lifetime Intake0.10.10.3-0.4-0.00.40.2-0.3-0.30.2-0.30.10.3-0.40.4-0.4-0.4-0.40.3-0.6-0.6-0.40.5-0.50.3
Liver weight, left0.20.31.20.90.3-0.5-0.20.40.4-0.20.5-0.5-0.50.6-0.60.40.60.6-0.70.40.40.6-0.70.91.1
Liver weight, right1.11.83.2-1.5-1.51.81.5-1.4-1.41.2-1.51.31.3-1.41.3-1.5-1.4-1.31.1-1.7-1.7-0.31.1-0.9-0.7
Locomotor activity1.01.62.51.31.1-1.0-1.21.21.2-1.51.4-1.3-1.11.4-1.31.21.21.2-1.61.41.40.8-1.51.11.2
Locomotor testing distance0.71.22.10.81.0-0.8-1.31.01.1-1.21.4-1.1-1.01.2-1.21.21.21.1-1.31.31.30.9-1.30.80.2
Locomotor testing rearing0.81.22.11.11.4-0.8-1.31.31.2-1.51.1-1.2-1.11.2-1.11.01.11.0-1.31.21.2-0.5-1.10.50.3
Locomotion in novel chamber0.10.10.7-0.20.2-0.2-0.3-0.2-0.10.30.2-0.00.00.2-0.30.30.30.4-0.20.70.70.6-0.80.2-0.6
Locomotion in novel chamber post-restriction2.83.44.4-2.0-1.72.11.9-1.8-2.02.0-2.02.01.9-1.81.8-2.1-1.9-1.81.7-1.9-1.9-1.61.7-1.9-1.2
Fecal boli incidents, locomotor time 10.10.10.40.30.0-0.0-0.60.30.4-0.60.6-0.5-0.50.0-0.20.50.10.2-0.60.40.40.1-0.3-0.10.4
Change in fecal boli incidents, locomotor task3.73.55.32.32.1-2.0-1.42.12.1-1.31.8-2.1-2.02.1-2.01.52.02.0-1.82.02.00.7-2.01.61.5
Time >=10cm from walls, locomotor time 10.70.72.7-1.1-0.11.00.3-0.6-0.70.2-1.20.50.6-0.60.7-0.7-0.6-0.61.0-1.0-1.0-1.21.1-0.7-1.7
Bouts of movement, locomotor time 10.60.71.60.90.4-1.2-0.90.80.7-0.41.3-0.7-0.80.7-0.71.10.80.8-0.70.70.71.0-0.70.40.9
Total resting periods, locomotor time 10.91.02.11.20.6-1.4-1.01.01.0-0.61.4-0.9-1.10.8-0.91.20.91.0-0.80.80.81.1-0.80.71.1
Rest time, locomotor task time 10.10.10.30.60.0-0.3-0.2-0.00.0-0.00.4-0.1-0.10.1-0.10.30.10.3-0.30.40.40.0-0.40.10.5
Distance moved, locomotor task time 10.30.31.40.21.2-0.1-0.30.80.7-0.9-0.0-0.6-0.70.8-0.70.20.80.6-0.40.20.20.1-0.20.7-0.2
Vertical activity count, locomotor time 10.10.10.5-0.70.10.70.2-0.0-0.3-0.2-0.60.40.3-0.20.2-0.4-0.2-0.30.2-0.2-0.2-0.30.1-0.1-0.4
Time >=10cm from walls, locomotor time 21.11.12.0-1.4-1.40.61.0-1.3-1.11.1-1.11.01.1-1.31.3-0.7-1.2-1.31.3-0.9-0.90.61.0-0.7-0.6
Bouts of movement, locomotor time 21.21.32.00.71.2-0.9-1.11.31.0-1.01.1-1.1-1.21.3-1.21.11.11.2-1.21.21.21.4-1.00.81.4
Total resting periods, locomotor time 20.60.61.20.30.8-0.5-0.91.00.6-0.80.8-0.7-0.80.9-0.90.80.70.9-0.90.70.71.1-0.60.40.9
Rest time, locomotor task time 20.10.10.5-0.00.10.3-0.20.2-0.20.30.3-0.0-0.00.0-0.0-0.1-0.10.0-0.1-0.3-0.3-0.60.2-0.70.2
Distance moved, locomotor task time 20.10.21.70.10.4-0.4-0.10.10.5-0.50.0-0.1-0.10.2-0.20.30.40.2-0.00.10.11.3-0.00.80.4
Vertical activity count, locomotor time 20.10.21.4-0.6-0.40.60.1-0.4-0.0-0.5-0.40.40.4-0.30.3-0.0-0.1-0.20.00.00.01.20.00.30.0
Light reinforcement 11.42.55.8-2.0-1.81.61.4-1.6-1.71.9-1.31.61.4-1.71.6-1.7-1.5-1.61.4-1.0-1.0-1.51.4-2.4-1.2
Light reinforcement 21.72.33.3-1.8-1.71.71.6-1.6-1.61.7-1.31.61.5-1.51.5-1.7-1.5-1.61.4-1.4-1.4-1.01.3-1.8-1.2
Bone: marrow area0.10.32.5-0.7-0.11.1-0.3-0.2-0.1-0.2-0.30.20.20.1-0.1-0.30.10.2-0.30.10.1-0.9-0.0-0.6-1.6
Bone: maximum diameter1.42.74.6-2.1-2.01.81.8-1.8-1.71.9-1.71.71.7-1.61.6-1.5-1.6-1.61.8-1.3-1.30.81.2-0.5-2.1
Bone: maximum force5.79.915.5-3.9-3.93.43.7-3.5-3.43.4-3.33.33.3-3.23.2-3.1-3.2-3.23.3-2.8-2.81.92.5-1.2-2.0
Bone: maximum moment6.611.317.8-4.1-4.23.54.0-3.7-3.63.7-3.63.53.6-3.53.4-3.4-3.4-3.43.6-3.0-3.01.62.7-1.5-2.2
Mean time between licks in bursts2.02.83.41.61.7-1.6-1.71.81.8-1.71.7-1.8-1.71.7-1.71.71.81.8-1.81.81.81.1-1.71.40.9
Mean num. licks in bursts0.20.32.80.1-0.30.20.6-0.2-0.30.7-0.50.20.2-0.30.3-0.6-0.4-0.20.4-0.4-0.4-1.70.5-0.50.3
Cd content in liver1.92.13.81.21.2-1.3-1.41.41.5-1.51.4-1.5-1.51.4-1.41.51.41.4-1.51.31.32.0-1.31.41.9
Co content in liver0.30.40.60.50.7-0.4-0.70.70.7-0.50.5-0.7-0.70.8-0.80.60.80.8-0.70.70.7-0.3-0.60.40.1
Cu content in liver0.10.11.10.40.1-0.50.30.10.00.2-0.1-0.10.0-0.20.0-0.0-0.2-0.20.20.00.00.1-0.00.41.0
Fe content in liver1.72.03.01.31.6-0.9-1.61.61.6-1.71.3-1.6-1.61.5-1.51.41.51.5-1.61.51.50.3-1.41.20.4
K content in liver1.51.43.2-1.3-0.81.40.8-1.0-1.10.6-1.21.11.1-1.31.2-1.2-1.3-1.31.1-1.4-1.4-1.81.3-1.5-0.8
Mg content in liver0.20.21.8-0.50.20.7-0.3-0.1-0.2-0.7-0.20.20.2-0.40.3-0.2-0.4-0.40.1-0.6-0.6-1.30.4-0.9-0.1
Mn content in liver0.20.20.4-0.3-0.40.30.5-0.5-0.50.2-0.40.50.5-0.50.5-0.3-0.5-0.50.5-0.7-0.70.00.4-0.00.3
Na content in liver0.20.20.50.50.7-0.4-0.40.50.4-0.40.3-0.4-0.50.4-0.40.30.40.4-0.20.40.4-0.4-0.20.40.1
Rb content in liver1.31.62.4-1.5-1.31.41.1-1.2-1.30.7-1.21.21.3-1.61.5-1.1-1.6-1.61.4-1.4-1.4-0.41.3-1.0-1.0
Se content in liver0.40.54.2-0.2-0.10.40.3-0.4-0.40.2-0.60.50.4-0.50.5-0.5-0.5-0.50.6-0.7-0.7-2.10.9-0.9-0.8
Sr content in liver0.10.11.00.80.3-1.00.10.20.20.20.1-0.2-0.20.3-0.30.20.30.30.1-0.0-0.0-0.3-0.10.5-0.3
Zn content in liver0.10.10.20.20.5-0.0-0.40.40.4-0.40.2-0.4-0.30.4-0.40.20.40.4-0.40.30.30.2-0.30.30.1
Bone: minimum diameter2.95.47.6-2.7-2.72.22.6-2.4-2.42.7-2.62.42.4-2.42.4-2.3-2.3-2.32.6-2.0-2.0-0.32.0-1.3-2.5
Time in familiar zone, hab. session 10.10.10.70.3-0.1-0.30.20.00.10.3-0.0-0.0-0.00.2-0.10.00.10.2-0.10.10.10.2-0.10.20.8
Time in novel zone, hab. session 10.00.00.1-0.20.0-0.0-0.00.0-0.0-0.10.1-0.0-0.0-0.20.2-0.0-0.2-0.20.1-0.1-0.10.00.1-0.3-0.1
Total zone transitions, hab. session 10.10.21.10.30.2-0.4-0.50.20.2-0.50.5-0.2-0.20.3-0.30.60.30.3-0.40.20.21.0-0.40.40.8
Total locomotion distance, hab. session 10.40.51.0-0.9-1.00.80.4-0.9-0.90.4-0.50.90.9-0.80.8-0.4-0.8-0.80.5-0.8-0.80.30.7-0.70.1
Locomotion velocity, hab. session 10.40.61.1-0.9-1.00.90.4-1.0-1.00.4-0.51.01.0-0.90.8-0.5-0.8-0.90.6-0.9-0.90.20.7-0.8-0.2
Time in familiar zone, hab. session 20.30.30.70.50.5-0.3-0.60.70.7-0.40.5-0.7-0.60.6-0.60.50.60.6-0.90.50.5-0.1-0.60.00.7
Time in novel zone, hab. session 20.10.10.7-0.0-0.0-0.20.0-0.1-0.1-0.20.10.10.0-0.10.00.2-0.0-0.10.3-0.0-0.00.80.00.5-0.3
Total zone transitions, hab. session 20.30.41.1-1.0-0.90.70.0-0.7-0.60.2-0.20.60.6-0.60.6-0.1-0.6-0.60.4-0.6-0.60.60.5-0.8-0.5
Total locomotion distance, hab. session 21.52.03.9-2.0-1.71.70.9-1.6-1.51.0-1.11.61.6-1.51.5-1.1-1.5-1.51.1-1.3-1.3-0.21.3-1.9-0.8
Locomotion velocity, hab. session 21.92.64.8-2.2-1.91.91.1-1.8-1.81.2-1.31.81.8-1.71.7-1.3-1.7-1.71.4-1.5-1.5-0.21.6-2.0-0.9
Novel to familiar place preference ratio2.12.13.9-1.3-1.61.02.0-1.5-1.61.9-1.61.51.5-1.51.5-1.6-1.5-1.51.7-1.5-1.5-0.31.5-0.8-0.6
Novelty place preference2.12.13.9-1.3-1.61.02.0-1.5-1.51.9-1.61.51.5-1.51.5-1.6-1.5-1.51.8-1.4-1.4-0.21.4-0.8-0.6
Time in novel zone, NPP test1.71.83.3-1.2-1.50.91.8-1.4-1.41.8-1.51.41.4-1.31.4-1.5-1.4-1.31.6-1.3-1.3-0.11.3-0.8-0.5
Total zone transitions, NPP test0.10.10.6-0.60.00.5-0.7-0.1-0.1-0.80.30.0-0.0-0.10.00.4-0.0-0.1-0.2-0.2-0.20.40.0-0.4-0.6
Total locomotion distance, NPP test0.50.61.9-1.3-0.71.4-0.0-0.9-0.8-0.2-0.40.80.8-0.80.8-0.4-0.8-0.80.3-0.9-0.9-0.10.7-1.2-0.4
Locomotion velocity, NPP test0.60.82.1-1.4-0.91.40.2-1.0-1.00.1-0.60.90.9-0.90.9-0.6-0.9-0.90.6-1.1-1.1-0.20.9-1.3-0.6
Intraocular pressure0.91.22.7-1.4-0.81.70.8-1.1-1.10.2-1.31.11.1-1.21.2-1.2-1.1-1.11.0-0.9-0.9-1.01.0-0.9-1.4
Delta distance traveled before/after self-admin0.40.51.10.40.8-0.1-1.00.70.8-1.00.8-0.8-0.80.6-0.70.50.60.4-0.90.50.5-0.9-0.5-0.50.4
Delta ambulatory time before/after self-admin1.11.22.20.81.1-0.4-1.41.31.5-1.41.4-1.5-1.40.9-1.00.91.00.8-1.40.90.9-0.7-1.0-0.40.8
Parametrial fat weight1.52.84.9-1.5-1.81.91.8-1.9-1.81.7-1.81.81.8-1.71.7-2.0-1.7-1.61.2-1.5-1.5-1.51.6-2.20.3
Pavlov. Cond. lever latency0.50.61.90.20.8-0.1-1.20.80.8-1.40.8-0.8-0.80.8-0.80.90.70.8-0.90.50.51.1-0.80.7-0.2
Pavlov. Cond. magazine entry latency1.01.32.9-0.6-1.00.71.7-1.1-1.11.7-1.41.11.1-1.11.1-1.4-1.1-1.01.2-0.9-0.9-1.61.1-0.7-0.6
Pavlov. Cond. change in total contacts0.10.10.60.6-0.1-0.40.4-0.1-0.00.4-0.10.10.10.1-0.1-0.10.10.1-0.10.40.4-0.4-0.10.20.8
Pavlov. Cond. index score2.02.54.4-1.2-1.61.22.0-1.7-1.72.1-1.81.71.7-1.61.6-1.8-1.6-1.61.7-1.3-1.3-1.71.6-1.4-0.7
Pavlov. Cond. latency score1.51.93.7-0.9-1.40.91.8-1.4-1.41.9-1.51.41.4-1.41.4-1.6-1.3-1.31.4-1.2-1.2-1.71.4-1.3-0.4
Pavlov. Cond. lever contacts0.40.41.0-0.3-0.60.40.8-0.7-0.71.0-0.70.70.7-0.70.7-0.8-0.6-0.60.6-0.4-0.4-1.00.7-0.70.0
Pavlov. Cond. magazine entry number0.81.02.60.21.0-0.4-1.61.01.0-1.61.2-1.0-1.00.9-0.91.30.90.9-1.00.60.61.4-0.90.50.1
Pavlov. Cond. intertrial magazine entries0.60.71.4-1.1-0.91.20.6-0.8-0.80.5-0.80.80.8-0.90.8-0.8-0.8-0.80.6-1.0-1.0-0.60.9-1.2-0.4
Pavlov. Cond. lever-magazine prob. diff.1.92.34.1-1.1-1.51.12.0-1.6-1.62.0-1.81.61.6-1.61.6-1.8-1.5-1.51.7-1.3-1.3-1.51.5-1.2-0.8
Pavlov. Cond. response bias0.70.92.2-0.3-0.90.51.5-0.9-0.91.5-1.10.91.0-0.90.9-1.2-0.9-0.81.0-0.6-0.6-1.20.8-0.6-0.1
Pavlov. Cond. lever latency0.91.22.31.41.1-1.5-0.71.11.1-0.71.0-1.0-1.01.0-1.01.11.01.0-0.91.11.11.0-1.21.31.3
Pavlov. Cond. magazine entry latency1.61.83.51.21.4-0.7-1.81.31.4-1.91.7-1.3-1.31.4-1.41.41.41.4-1.71.31.30.5-1.40.60.9
Pavlov. Cond. change in total contacts0.10.10.5-0.10.40.3-0.60.30.3-0.60.2-0.3-0.30.3-0.30.30.40.3-0.40.30.30.2-0.20.1-0.7
Pavlov. Cond. index score0.10.10.60.10.40.4-0.60.20.3-0.70.4-0.2-0.20.3-0.30.20.40.3-0.50.10.1-0.3-0.1-0.2-0.1
Pavlov. Cond. latency score0.10.10.3-0.10.10.5-0.50.00.1-0.60.2-0.0-0.00.2-0.20.10.20.2-0.40.00.0-0.40.0-0.4-0.3
Pavlov. Cond. lever contacts1.31.83.2-1.6-1.21.80.9-1.3-1.30.8-1.21.31.3-1.31.3-1.3-1.3-1.31.2-1.4-1.4-1.31.5-1.6-1.6
Pavlov. Cond. magazine entry number1.41.73.8-1.1-1.50.61.8-1.3-1.32.0-1.51.31.2-1.31.3-1.3-1.4-1.31.7-1.1-1.1-0.41.2-0.7-1.0
Pavlov. Cond. intertrial magazine entries2.43.14.1-1.9-1.71.61.8-1.8-1.91.7-2.01.81.8-1.81.8-1.7-1.9-1.82.0-2.0-2.0-0.91.8-1.1-1.8
Pavlov. Cond. lever-magazine prob. diff.0.20.20.80.20.60.2-0.80.30.4-0.90.5-0.4-0.40.5-0.50.40.50.5-0.70.20.2-0.3-0.3-0.10.1
Pavlov. Cond. response bias0.10.10.7-0.5-0.10.8-0.1-0.2-0.2-0.3-0.10.20.2-0.20.2-0.3-0.2-0.20.0-0.4-0.4-0.40.3-0.6-0.4
Time in closed arm before self-admin0.30.31.30.70.5-0.5-0.20.80.8-0.80.5-0.8-0.70.3-0.30.40.40.3-0.2-0.0-0.00.70.01.10.1
Time in closed arm after self-admin1.41.42.41.51.5-1.4-0.71.41.3-1.01.2-1.3-1.11.1-1.10.91.21.3-1.11.11.11.0-1.11.51.3
Time in open arm before self-admin0.50.62.6-1.1-1.20.30.5-0.9-0.81.6-0.30.70.8-0.70.6-0.4-0.6-0.60.7-0.4-0.40.10.3-1.4-0.5
Time in open arm after self-admin0.10.10.2-0.2-0.3-0.1-0.2-0.00.40.20.1-0.3-0.30.1-0.20.20.1-0.0-0.20.40.40.2-0.5-0.3-0.2
Bone: periosteal estimation2.14.47.9-2.8-2.62.52.2-2.3-2.22.2-2.32.22.2-2.02.0-2.1-2.0-2.02.1-1.7-1.70.71.6-1.0-2.4
Bone: periosteal perimeter2.64.48.2-2.3-2.61.92.6-2.2-2.12.9-2.42.12.2-2.12.1-2.2-2.0-2.02.4-1.7-1.70.31.8-0.8-2.1
Bone: post-yield work0.10.11.0-0.6-0.10.4-0.1-0.1-0.00.1-0.20.10.10.0-0.0-0.00.00.10.1-0.0-0.00.70.00.2-1.0
Progressive ratio test 1 active lever presses0.50.51.3-0.9-0.31.10.6-0.4-0.60.4-0.80.40.5-0.80.8-0.9-0.8-0.90.6-0.6-0.6-1.10.4-0.8-0.6
Progressive ratio test 1 breakpoint1.11.12.0-1.2-0.81.41.0-0.8-1.00.8-1.10.80.9-1.21.2-1.3-1.2-1.30.9-0.9-0.9-1.40.7-1.2-0.8
Progressive ratio test 1 inactive lever presses0.91.01.6-1.2-0.71.21.1-0.6-0.90.5-1.30.80.7-1.11.1-1.2-1.1-1.21.1-1.2-1.2-0.61.1-0.7-0.2
Progressive ratio test 2 active lever presses0.40.41.1-0.6-0.40.90.5-0.9-0.60.5-0.60.60.6-0.60.6-0.8-0.5-0.60.3-0.5-0.5-1.00.3-0.7-0.3
Progressive ratio test 2 breakpoint0.50.61.2-0.8-0.61.10.6-1.1-0.80.6-0.80.80.8-0.70.7-0.9-0.7-0.80.5-0.6-0.6-1.10.4-0.9-0.5
Progressive ratio test 2 inactive lever presses0.10.10.2-0.30.00.30.4-0.2-0.20.4-0.40.00.1-0.10.1-0.4-0.1-0.20.2-0.3-0.3-0.30.10.1-0.2
Incentive Sensitization - Responses0.90.92.0-0.8-1.01.00.8-1.4-1.11.0-0.81.11.1-0.90.9-1.0-0.8-0.90.7-0.8-0.8-1.40.7-1.3-0.4
Incentive Sensitization - Breakpoint0.80.81.8-0.7-1.00.90.8-1.3-1.00.9-0.71.01.0-0.80.8-0.9-0.8-0.80.6-0.7-0.7-1.40.6-1.2-0.4
Sum of active levers in priming session hrs 5-60.20.20.70.60.30.20.30.00.40.2-0.2-0.3-0.10.6-0.5-0.30.50.6-0.50.20.2-0.4-0.30.40.8
Progressive ratio0.50.61.20.70.7-0.3-0.91.00.7-1.10.4-0.9-0.90.9-0.90.81.00.9-0.80.70.70.6-0.50.90.1
Food seeking constrained by brief footshock0.20.30.90.80.7-0.7-0.40.50.6-0.40.4-0.6-0.60.5-0.50.50.30.5-0.30.30.3-0.3-0.30.51.0
Seeking ratio, punishment vs. effort0.30.40.7-0.5-0.40.20.6-0.7-0.40.8-0.30.50.6-0.70.8-0.5-0.8-0.70.7-0.6-0.6-0.70.4-0.70.2
Retroperitoneal fat weight3.812.418.8-3.6-3.44.33.4-3.8-3.72.9-3.73.73.6-3.73.7-3.9-3.6-3.83.1-3.5-3.5-3.13.4-3.5-2.2
Reaction time number correct0.30.42.9-1.4-0.51.1-0.2-0.4-0.5-0.4-0.40.40.5-0.60.6-0.2-0.5-0.50.4-0.1-0.10.20.4-0.8-1.7
Reaction time mean minus median0.60.71.71.30.9-0.8-0.60.90.9-0.80.8-0.9-0.81.1-1.00.60.80.7-1.00.80.8-0.1-0.90.51.2
Reaction time mean minus median AUC0.10.10.20.50.3-0.2-0.20.30.2-0.30.3-0.3-0.20.4-0.30.20.20.2-0.30.10.10.0-0.30.20.4
Reaction time num false alarms0.10.10.80.1-0.2-0.2-0.20.20.30.20.0-0.2-0.10.3-0.30.20.50.3-0.10.30.3-0.1-0.1-0.2-0.9
Reaction time num false alarms AUC0.20.30.60.40.2-0.4-0.70.50.6-0.30.5-0.5-0.40.6-0.60.60.80.6-0.40.60.60.1-0.30.0-0.7
Reaction time trials correct on left0.30.42.9-1.4-0.51.1-0.2-0.4-0.5-0.4-0.40.40.5-0.60.6-0.2-0.5-0.50.4-0.1-0.10.20.4-0.8-1.7
Reaction time trials on left0.30.42.9-1.4-0.41.1-0.3-0.4-0.4-0.4-0.30.40.5-0.60.6-0.1-0.5-0.50.3-0.1-0.10.20.4-0.7-1.7
Reaction time mean0.20.30.6-0.4-0.70.70.6-0.6-0.60.5-0.60.60.6-0.30.4-0.6-0.5-0.50.3-0.5-0.5-0.50.4-0.8-0.0
Reaction time mean AUC0.30.40.8-0.6-0.80.80.4-0.7-0.70.4-0.60.70.8-0.50.5-0.6-0.7-0.60.4-0.7-0.7-0.30.5-0.9-0.3
Median of all reaction times0.30.40.7-0.7-0.90.70.6-0.7-0.70.6-0.80.70.8-0.50.6-0.7-0.7-0.60.5-0.6-0.6-0.30.5-0.8-0.3
Reaction time omissions0.00.10.30.10.30.1-0.30.30.2-0.50.2-0.3-0.10.3-0.20.10.00.1-0.30.10.1-0.4-0.2-0.3-0.1
Reaction time false alarm rate0.30.41.11.00.4-0.9-0.50.60.8-0.00.5-0.6-0.60.8-0.80.50.90.8-0.50.60.6-0.2-0.50.40.1
Reaction time premature initiation rate0.70.91.61.00.8-1.1-1.00.90.9-0.71.1-0.9-0.91.1-1.11.01.01.0-1.11.31.30.3-1.00.50.7
Reaction time premature initiations0.30.41.00.10.5-0.2-1.00.50.5-0.90.8-0.5-0.40.7-0.60.70.60.5-0.81.01.00.3-0.6-0.0-0.3
Std. dev. reaction times0.30.40.70.90.6-0.5-0.70.70.6-0.80.7-0.6-0.50.8-0.80.60.60.6-0.80.50.50.1-0.60.30.6
Reaction time trials completed0.30.42.9-1.4-0.41.1-0.3-0.4-0.4-0.4-0.30.40.5-0.60.6-0.1-0.5-0.50.3-0.1-0.10.20.4-0.7-1.7
Reaction time trials AUC0.40.53.1-1.5-0.61.1-0.2-0.5-0.5-0.3-0.50.50.6-0.70.7-0.2-0.6-0.60.4-0.2-0.20.10.5-0.8-1.8
Run reversals in cocaine runway, females0.10.11.4-0.00.00.1-0.50.40.4-0.40.3-0.2-0.20.2-0.20.20.10.3-0.30.30.3-0.3-0.1-0.3-1.2
Run reversals in cocaine runway, males0.60.61.8-0.3-0.80.71.1-0.6-0.71.0-0.80.70.7-0.90.7-1.1-0.9-1.00.6-0.6-0.6-1.40.4-0.70.1
Latency to leave start box in cocaine runway0.10.10.60.0-0.10.3-0.50.50.3-0.80.5-0.6-0.50.1-0.00.20.00.1-0.4-0.2-0.2-0.20.2-0.5-0.0
Latency to leave start box in cocaine runway, F0.20.20.8-0.5-0.70.7-0.40.3-0.1-0.70.3-0.2-0.2-0.50.50.1-0.4-0.50.1-0.7-0.7-0.10.6-0.9-0.4
Latency to leave start box in cocaine runway, M0.10.10.30.20.30.20.1-0.00.2-0.10.0-0.2-0.10.3-0.2-0.30.30.3-0.40.20.2-0.5-0.1-0.30.2
Std. dev. time between licks in bursts0.50.62.0-1.4-0.51.30.1-0.7-0.8-0.3-0.70.70.8-0.90.9-0.5-0.8-0.80.5-0.5-0.50.10.6-0.6-1.2
Total sessions with >9 infusions0.20.20.70.30.5-0.3-0.60.40.5-0.60.5-0.6-0.50.5-0.50.50.40.4-0.60.40.40.8-0.40.40.5
Short access day 1 total inactive lever presses0.10.10.4-0.6-0.30.6-0.1-0.1-0.2-0.10.00.10.10.0-0.0-0.1-0.10.1-0.3-0.1-0.10.2-0.0-0.70.6
Short access day 10 total inactive lever presses1.31.42.8-1.2-0.91.31.6-1.7-1.51.2-1.71.51.5-1.11.1-1.6-1.1-1.11.0-0.8-0.8-0.50.7-0.7-0.3
Short access day 1 total infusions2.12.22.91.51.4-1.7-1.41.31.5-0.91.6-1.7-1.41.7-1.71.51.71.7-1.51.51.51.3-1.61.21.1
Short access day 10 total infusions0.10.20.8-0.20.10.50.4-0.4-0.20.4-0.50.10.2-0.30.3-0.6-0.3-0.30.3-0.5-0.5-0.90.5-0.40.0
Short access total infusions0.00.00.40.20.2-0.2-0.1-0.00.10.10.2-0.3-0.10.1-0.10.00.00.1-0.1-0.0-0.0-0.0-0.0-0.20.6
Short access day 1 locomotion0.60.61.40.90.5-1.2-0.50.50.80.00.8-0.8-0.70.9-0.90.80.91.0-0.60.70.71.0-0.81.00.8
Short access day 10 total locomotion0.91.03.01.21.1-1.2-0.40.81.1-0.70.8-1.1-1.00.7-0.70.70.70.6-0.90.90.90.9-1.21.21.7
Short access total locomotion0.70.81.90.90.8-1.1-0.50.70.9-0.50.8-1.0-1.00.6-0.60.80.60.6-0.70.90.91.2-1.11.01.4
One hour access (0.3 mA shock)1.82.13.0-1.4-1.21.61.2-1.7-1.61.2-1.41.51.7-1.41.4-1.5-1.4-1.51.2-1.6-1.6-1.71.4-1.7-0.7
Compulsive drug intake0.80.81.6-0.9-1.10.80.8-1.3-1.20.3-0.81.21.2-1.01.0-0.7-1.0-1.00.9-0.9-0.9-0.30.8-0.7-0.5
One hour access (shock baseline)0.60.81.8-1.0-0.71.00.5-0.8-0.90.9-0.60.70.8-0.90.9-0.8-0.8-0.90.7-1.1-1.1-0.91.0-1.3-0.1
Social response proportion1.61.72.90.81.4-0.8-1.11.41.3-1.40.9-1.5-1.41.4-1.31.11.41.5-1.31.41.41.7-1.41.60.4
Social responses0.60.84.00.20.8-0.8-0.70.80.6-0.70.8-0.8-0.80.7-0.70.80.80.8-0.71.11.12.0-1.01.00.4
Social time0.20.22.7-0.2-0.1-0.2-0.20.20.2-0.20.3-0.2-0.20.3-0.20.40.40.4-0.30.70.71.7-0.60.5-0.2
Soleus weight1.95.66.3-2.5-2.42.22.3-2.4-2.52.4-2.22.42.4-2.42.4-2.4-2.4-2.42.5-2.4-2.4-1.92.3-2.4-2.2
Bone: stiffness1.01.66.9-1.7-1.71.51.4-1.4-1.31.1-1.01.21.3-1.11.1-1.0-1.0-1.00.9-1.0-1.02.60.50.20.0
Tibialis anterior weight0.30.92.9-1.2-1.11.10.6-1.0-0.91.0-0.70.90.9-0.90.9-0.9-0.9-0.90.8-0.7-0.7-1.00.8-1.7-1.0
Time to tail flick, vehicle, before self-admin0.40.51.1-0.3-0.40.40.2-0.5-0.80.1-0.60.90.7-0.60.6-0.2-0.9-0.70.8-1.0-1.0-0.71.0-0.2-0.8
Time to tail flick, vehicle, after self-admin1.01.12.60.70.5-1.1-1.11.31.0-0.71.4-1.0-1.00.8-0.81.31.30.9-1.01.01.01.6-1.20.70.9
Time to tail flick, test, before self-admin0.60.53.00.61.10.0-0.31.00.8-1.70.4-0.8-1.00.1-0.00.20.20.0-0.70.40.4-0.2-0.20.51.6
Time to tail flick, test, after self-admin1.81.83.21.51.7-1.3-1.21.51.6-1.81.3-1.6-1.51.2-1.21.31.11.2-1.31.11.11.0-1.11.51.0
Delta time to tail flick, vehicle, before/after SA0.20.20.9-0.1-0.1-0.0-0.40.60.3-0.10.7-0.5-0.50.1-0.10.20.60.2-0.60.60.60.4-0.6-0.61.0
Delta time to tail flick, test, before/after SA0.90.82.20.90.4-1.3-0.50.60.90.30.8-0.9-0.71.2-1.30.91.01.2-0.80.80.81.5-0.91.10.3
Tibia length9.125.637.6-5.4-6.04.66.1-5.5-5.65.9-5.45.45.4-5.25.2-5.2-5.2-5.25.8-4.9-4.90.34.6-2.6-3.4
Ambulatory time before self-admin0.70.81.8-0.4-0.50.41.1-0.6-0.80.6-1.20.90.8-0.91.0-0.8-1.0-0.91.3-0.9-0.9-0.41.00.3-1.2
Ambulatory time after self-admin0.20.22.30.10.30.3-0.10.10.3-0.5-0.2-0.2-0.2-0.10.1-0.2-0.2-0.30.0-0.3-0.3-1.50.3-0.3-0.8
Bone: tissue strength1.51.43.3-1.8-1.41.61.1-1.3-1.30.8-1.21.21.2-1.31.2-1.0-1.3-1.21.3-0.8-0.80.80.9-0.5-1.5
Total heroin consumption1.01.13.70.90.5-0.6-0.21.11.5-0.50.6-1.4-1.41.1-1.10.61.11.0-0.70.70.71.9-0.61.90.8
Bone: trabecular number0.10.20.8-0.3-0.30.10.3-0.2-0.20.6-0.30.20.2-0.30.3-0.3-0.4-0.30.6-0.5-0.5-0.90.6-0.6-0.9
Bone: trabecular spacing0.20.21.5-1.0-0.11.2-0.2-0.4-0.4-0.8-0.30.30.3-0.30.3-0.2-0.3-0.3-0.0-0.3-0.30.30.2-0.4-0.7
Bone: trabecular thickness0.30.32.6-0.0-0.7-0.21.1-0.4-0.41.6-0.60.40.4-0.30.3-0.7-0.3-0.20.6-0.4-0.4-0.60.4-0.3-0.0
Bone: trabecular tissue density1.11.63.21.31.4-0.9-1.41.21.3-1.81.2-1.3-1.31.3-1.21.31.31.2-1.41.11.11.1-1.21.41.2
Water consumed over 24 hours0.10.10.70.40.1-0.60.10.10.10.50.0-0.0-0.10.1-0.10.00.00.20.2-0.2-0.2-0.80.2-0.20.8
Number of responses in last shaping day0.20.20.6-0.7-0.50.40.6-0.4-0.40.6-0.60.30.4-0.40.4-0.4-0.5-0.50.5-0.5-0.50.80.30.10.0