Hub : Genes

Tbc1d31

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Tbc1d31	0.03	0.04	5.2e-03	0.03	0.03	0.03	0.03	2.5e-03	2.7e-03	1.8e-03	2.3e-03
2	Adipose	mRNA stability	Tbc1d31	0.02	0.03	2.4e-03	0.01	0.01	0.01	0.01	7.0e-03	8.0e-03	2.7e-02	2.1e-02
3	pVTA	intron excision ratio	chr7_91345587_91349257	0.44	0.2	4.2e-03	0.03	0.03	0.03	0.02	3.2e-03	3.2e-03	1.7e-03	6.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.3	2.2	3.4	1.8	1.5	-0.9
Area under the delay curve	0.4	0.4	1.2	0.1	0.1	1.1
BMI with tail	4.3	14.9	17.0	4.1	3.8	-3.7
BMI without tail	2.3	6.9	8.3	2.6	2.4	-2.9
Body weight	5.1	22.3	27.7	4.5	4.4	-5.3
Weight adjusted by age	2.2	3.3	4.2	1.9	2.1	-1.5
Bone surface	0.1	0.1	0.2	0.2	0.4	-0.3
Bone volume	0.1	0.1	0.2	0.3	0.4	-0.0
Breakpoint value in progressive ratio session	0.9	1.1	1.7	-1.2	-1.3	-0.4
Number of licking bursts	1.1	1.7	2.7	-1.3	-1.6	0.9
Context. condit. distance diff. score	0.2	0.3	0.5	0.5	0.7	-0.1
Locomotion velocity, session 1	0.1	0.1	0.4	-0.2	0.2	0.6
Locomotion distance, session 1	0.1	0.1	0.2	0.4	0.3	0.2
Locomotion velocity, session 2	1.0	1.2	1.8	1.0	0.9	-1.4
Locomotion distance, session 2	0.2	0.2	0.7	0.1	-0.2	-0.8
Locomotion velocity, session 3	0.2	0.2	0.6	-0.3	-0.2	0.8
Locomotion distance, session 3	0.2	0.2	0.5	-0.3	-0.7	0.3
Stereotopy head waving bouts, day 3	1.1	1.3	2.2	0.9	1.5	-0.9
Stereotopy head waving duration, day 3	0.2	0.2	0.7	0.2	0.8	-0.0
Locomotion velocity, session 7	1.7	1.8	2.3	-1.5	-1.3	1.2
Locomotion distance, session 7	4.1	5.1	7.4	-2.7	-2.6	1.2
Stereotopy head waving bouts, day 7	0.4	0.5	0.5	0.6	0.7	-0.7
Stereotopy head waving duration, day 7	0.1	0.1	0.1	0.3	0.3	-0.4
Locomotion velocity, session 8	1.1	1.3	2.2	1.5	1.3	-0.5
Locomotion distance, session 8	0.0	0.1	0.1	0.3	0.1	0.3
Degree of sensitization distance	1.7	1.8	2.8	-1.7	-1.4	0.7
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.0	-0.1	-0.1
Conditioned locomotion	2.1	2.4	3.3	-1.8	-1.7	1.0
Cocaine response after cond. corrected	0.5	0.6	1.2	0.7	0.3	-1.1
Cocaine response after cond. not corrected	0.9	1.1	1.3	1.2	0.8	-1.2
Cocaine response before conditioning	1.0	1.2	1.9	1.1	1.4	-0.6
Saline control response	0.0	0.0	0.1	-0.0	-0.2	0.3
Bone: connectivity density	0.8	1.3	1.6	1.2	0.9	-1.3
Bone: cortical apparent density	2.9	4.0	5.2	-2.2	-1.5	2.3
Bone: cortical area	0.2	0.3	0.4	-0.6	-0.5	0.5
Bone: cortical porosity	0.5	0.6	1.3	0.7	1.1	0.1
Bone: cortical porosity	0.4	0.4	1.1	0.4	1.0	0.2
Bone: cortical thickness	0.0	0.1	0.2	0.3	0.4	0.0
Bone: cortical thickness	0.3	0.3	0.8	-0.1	-0.3	-0.9
Bone: cortical tissue density	3.0	4.1	5.1	-2.2	-1.5	2.3
Condit. Reinf. active minus inactive responses	0.5	0.6	1.5	0.0	-0.5	-1.2
Condit. Reinf. active-inactive response ratio	0.9	0.9	2.2	-0.2	-0.7	-1.5
Condit. Reinf. active responses	0.2	0.3	0.6	0.4	0.2	-0.8
Condit. Reinf. inactive responses	0.6	0.7	1.3	0.8	1.1	0.4
Incentive salience index mean	0.6	0.8	2.2	0.2	-0.2	-1.5
Condit. Reinf. lever presses	0.5	0.7	2.1	0.3	0.3	-1.4
Condit. Reinf. active minus inactive responses	1.1	1.4	2.2	1.5	1.4	0.1
Condit. Reinf. active-inactive response ratio	0.8	0.9	2.4	0.4	0.5	1.5
Condit. Reinf. active responses	1.6	2.2	3.5	1.9	1.7	-0.4
Condit. Reinf. inactive responses	0.8	1.0	1.6	1.0	0.7	-1.3
Condit. Reinf. lever presses	1.8	2.5	3.9	2.0	1.7	-0.9
Condit. Reinf. lever reinforcers received	1.2	1.7	2.9	1.7	1.5	-0.2
Conditioned reinforcement - actives	0.2	0.3	0.7	0.5	0.3	-0.8
Conditioned reinforcement - inactives	0.5	0.8	1.3	-1.2	-1.0	-0.3
Conditioned locomotion	0.2	0.2	0.4	0.4	0.3	0.6
Patch foraging indifference point 0 sec	0.9	1.7	3.8	1.1	0.3	-1.9
Patch foraging indifference point AUC	0.2	0.2	0.5	0.4	0.2	-0.7
Delay disc. indifference point, 0s delay	0.7	0.8	1.9	0.1	0.7	1.4
Delay disc. indifference point, 16s delay	1.9	2.1	3.9	-1.1	-1.1	2.0
Delay disc. indifference point, 2s delay	1.4	1.6	2.3	1.5	1.5	0.4
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.0	-0.4	0.1
Delay disc. indifference point, 4s delay	0.8	0.9	1.3	1.1	0.8	-0.8
Delay disc. indifference point, 8s delay	0.4	0.5	0.8	-0.5	-0.5	0.9
Indifference point function ln k	0.5	0.9	1.4	1.2	1.1	-0.3
Indifference point function log k	0.5	0.9	1.4	1.2	1.1	-0.3
Patch foraging total patch changes 0 sec	0.5	1.0	2.4	0.8	0.1	-1.6
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	-0.3	-0.7	-0.1
Patch foraging total patch changes 18 sec	0.2	0.3	0.7	0.4	0.1	-0.9
Patch foraging total patch changes 24 sec	0.5	0.9	0.9	-0.9	-1.0	-0.9
Patch foraging total patch changes 6 sec	0.3	0.5	0.9	0.0	-0.9	-0.8
Patch foraging time to switch 0 sec	0.8	1.6	2.2	-1.4	-0.8	1.5
Patch foraging water rate 0 sec	1.6	3.3	4.6	2.1	1.2	-1.9
Patch foraging water rate 12 sec	0.2	0.3	0.7	0.8	0.5	-0.2
Patch foraging water rate 18 sec	0.7	1.0	1.6	1.1	1.3	-0.3
Patch foraging water rate 24 sec	0.5	0.8	1.6	1.3	0.8	0.1
Patch foraging water rate 6 sec	1.7	2.5	3.3	1.8	1.6	-1.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.5	-0.6	-0.3	0.7
Distance traveled before self-admin	0.1	0.1	0.2	0.2	-0.3	0.4
Distance traveled after self-admin	0.6	0.7	1.6	0.6	0.3	1.3
Extensor digitorum longus weight	4.3	16.7	17.4	4.2	3.9	-4.2
Bone: elastic displacement	0.9	1.1	1.9	1.1	1.4	0.5
Bone: elastic work	1.1	1.4	2.5	1.3	1.6	0.2
Bone: endosteal estimation	0.7	1.5	2.3	-1.3	-1.5	0.6
Bone: endosteal perimeter	1.0	2.1	2.8	-1.7	-1.4	1.2
Epididymis fat weight	0.0	0.1	0.2	-0.1	0.1	-0.4
Delta time in closed arm before/after self-admin	0.9	0.8	2.3	-0.2	-0.4	1.5
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.1	-0.0	-0.2
Diff in mean of infusions in LGA sessions	0.7	0.8	1.9	0.6	0.4	-1.4
Delay discount exponential model param	0.2	0.3	0.7	-0.1	-0.0	-0.9
Extinction: sum of active levers before priming	2.7	3.0	4.0	-1.9	-2.0	-1.2
Active lever presses in extinction session 6	0.4	0.4	0.7	-0.7	-0.9	-0.2
Bone: final force	1.0	1.6	2.0	1.2	1.4	-1.0
Bone: final moment	0.7	1.1	1.4	1.0	1.2	-0.9
Food consumed during 24 hour testing period	0.2	0.2	0.3	-0.5	-0.6	-0.4
Glucose	3.4	5.3	5.8	-2.2	-2.3	2.4
Heart weight	0.5	0.8	1.7	0.6	0.5	-1.3
Delay discount hyperbolic model param	0.2	0.2	0.5	-0.4	-0.3	-0.7
Intermittent access intake day 1-15 change	0.7	1.5	2.6	-1.6	-1.3	0.4
Intermittent access intake escalation	0.5	1.0	1.8	-1.4	-1.1	0.2
Intermittent access intake escalation 2	0.5	0.6	0.9	-0.8	-0.9	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.3	0.0	-0.1
Intermitt. access day 15 inactive lever presses	0.2	0.4	1.0	0.5	1.0	-0.1
Intermitt. access escalation Index	0.8	1.2	2.5	0.8	0.6	-1.6
Intermittent access day 1 total infusions	1.0	1.6	2.0	-1.4	-1.0	1.4
Intermittent access day 15 total infusions	2.1	3.2	4.8	-2.2	-1.7	1.4
Intermittent access terminal intake (last 3 days)	3.6	4.7	7.2	-2.7	-2.3	1.2
Intermittent access total infusions	2.7	3.2	4.8	-2.2	-1.8	1.3
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.3	-0.0	-0.4
Intermittent access day 15 total locomotion	0.3	0.5	1.3	-1.1	-0.4	0.1
Intermittent access total locomotion	0.3	0.3	0.7	-0.8	-0.4	-0.3
Intermittent access standard deviation	0.8	1.7	2.6	-1.6	-1.6	-0.0
Left kidney weight	1.6	7.2	8.8	2.7	3.0	-2.3
Right kidney weight	1.4	6.3	7.8	2.8	2.7	-2.0
Cocaine induced anxiety	3.2	4.6	6.4	-2.1	-2.5	1.7
Post-drug Anxiety	2.7	2.9	4.3	-1.6	-2.1	1.4
Baseline Anxiety	0.4	0.4	0.8	0.7	0.9	-0.0
Tail length	0.1	0.2	0.7	0.1	0.2	-0.8
Length with tail	1.0	4.4	8.2	1.5	1.7	-2.9
Length without tail	2.0	6.3	8.5	2.2	2.3	-2.9
Times rat made contact with spout	2.4	2.8	3.8	-1.7	-1.3	2.0
Lifetime Intake	1.9	2.3	3.7	-1.9	-1.6	0.8
Liver weight, left	1.1	1.9	3.8	0.9	1.1	-1.9
Liver weight, right	2.5	4.3	4.4	2.1	2.0	-2.1
Locomotor activity	2.4	3.8	4.9	2.2	2.2	-1.3
Locomotor testing distance	1.1	2.1	3.7	1.5	1.9	-0.4
Locomotor testing rearing	0.4	0.9	1.2	1.1	1.0	-0.6
Locomotion in novel chamber	1.6	2.0	2.9	1.6	1.7	-0.7
Locomotion in novel chamber post-restriction	0.3	0.4	1.2	0.4	-0.1	-1.1
Fecal boli incidents, locomotor time 1	1.5	2.2	2.8	-1.7	-1.7	1.1
Change in fecal boli incidents, locomotor task	0.6	0.6	1.7	0.3	-0.1	-1.3
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.2	-0.5	-0.0	-1.1
Bouts of movement, locomotor time 1	2.5	2.8	4.4	-2.1	-1.9	0.6
Total resting periods, locomotor time 1	2.2	2.5	3.8	-1.9	-1.9	0.0
Rest time, locomotor task time 1	4.1	5.1	6.0	-2.2	-2.5	2.0
Distance moved, locomotor task time 1	1.0	1.5	2.1	0.9	1.3	-1.5
Vertical activity count, locomotor time 1	1.2	3.0	3.8	1.5	2.0	-1.7
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	-0.6	-0.5	0.3
Bouts of movement, locomotor time 2	0.6	0.9	1.9	-1.4	-0.6	0.6
Total resting periods, locomotor time 2	0.5	0.9	1.8	-1.3	-0.5	0.7
Rest time, locomotor task time 2	0.9	1.2	1.9	-1.2	-1.4	0.6
Distance moved, locomotor task time 2	0.9	1.1	2.1	0.8	0.8	-1.4
Vertical activity count, locomotor time 2	0.9	1.2	2.0	0.8	1.0	-1.4
Light reinforcement 1	0.1	0.2	0.2	-0.5	0.2	0.5
Light reinforcement 2	0.3	0.5	1.1	-1.1	-0.4	-0.1
Bone: marrow area	0.6	1.4	2.3	-1.3	-1.5	0.5
Bone: maximum diameter	1.8	3.4	4.3	-2.1	-1.9	1.5
Bone: maximum force	0.5	0.8	1.2	1.0	1.1	-0.5
Bone: maximum moment	0.3	0.5	0.8	0.8	0.9	-0.3
Mean time between licks in bursts	0.7	1.7	3.3	-1.4	-0.1	1.8
Mean num. licks in bursts	0.1	0.2	0.4	0.1	0.7	0.2
Cd content in liver	0.6	0.6	1.0	0.4	1.0	-0.8
Co content in liver	0.0	0.0	0.0	0.1	0.1	0.1
Cu content in liver	0.6	0.7	1.2	0.9	1.1	0.3
Fe content in liver	0.2	0.3	0.6	0.5	0.8	0.3
K content in liver	1.3	1.3	3.8	0.1	0.3	1.9
Mg content in liver	0.3	0.3	1.0	-0.0	-0.0	1.0
Mn content in liver	0.6	0.6	1.9	-0.1	0.2	1.4
Na content in liver	0.0	0.0	0.1	0.1	-0.1	-0.3
Rb content in liver	0.7	0.8	1.8	-0.8	-1.3	-0.2
Se content in liver	2.4	2.9	4.6	2.2	1.6	-1.1
Sr content in liver	1.1	1.0	1.2	0.9	1.1	-1.0
Zn content in liver	1.0	1.1	1.7	1.3	1.2	0.2
Bone: minimum diameter	1.3	2.4	2.9	-1.7	-1.4	1.5
Time in familiar zone, hab. session 1	0.4	0.4	0.8	-0.9	-0.1	0.5
Time in novel zone, hab. session 1	0.5	0.5	1.1	-0.4	-1.0	0.4
Total zone transitions, hab. session 1	2.6	3.6	4.4	2.1	1.8	-1.8
Total locomotion distance, hab. session 1	2.0	2.8	3.7	1.9	1.9	-1.1
Locomotion velocity, hab. session 1	1.2	1.7	2.6	1.6	1.5	-0.6
Time in familiar zone, hab. session 2	2.3	2.4	3.1	-1.8	-1.6	1.2
Time in novel zone, hab. session 2	0.5	0.5	0.9	1.0	0.6	-0.2
Total zone transitions, hab. session 2	0.5	0.7	1.4	1.2	0.8	-0.0
Total locomotion distance, hab. session 2	0.4	0.6	1.1	1.0	0.6	0.5
Locomotion velocity, hab. session 2	0.3	0.4	0.8	0.9	0.5	0.3
Novel to familiar place preference ratio	1.5	1.7	1.9	1.4	1.3	-1.2
Novelty place preference	1.5	1.6	2.2	1.5	1.4	-0.9
Time in novel zone, NPP test	1.3	1.4	1.8	1.4	1.2	-0.9
Total zone transitions, NPP test	0.7	1.0	2.0	1.4	0.8	-0.6
Total locomotion distance, NPP test	0.5	0.7	1.5	1.2	0.7	0.2
Locomotion velocity, NPP test	0.5	0.7	1.3	1.1	0.8	0.4
Intraocular pressure	0.7	1.0	2.1	-0.1	-0.9	-1.4
Delta distance traveled before/after self-admin	0.2	0.2	0.3	0.3	0.3	0.6
Delta ambulatory time before/after self-admin	0.1	0.2	0.2	0.5	0.4	0.4
Parametrial fat weight	0.5	1.3	2.0	1.2	1.4	-0.8
Pavlov. Cond. lever latency	1.0	1.3	1.9	1.3	1.4	0.2
Pavlov. Cond. magazine entry latency	0.8	1.0	1.6	-1.2	-1.3	-0.2
Pavlov. Cond. change in total contacts	1.0	1.1	1.6	-1.3	-1.2	0.3
Pavlov. Cond. index score	1.7	2.1	3.5	-1.9	-1.6	0.3
Pavlov. Cond. latency score	1.8	2.3	3.4	-1.9	-1.8	0.2
Pavlov. Cond. lever contacts	0.9	1.1	1.6	-1.3	-1.3	-0.2
Pavlov. Cond. magazine entry number	0.9	1.1	1.8	1.3	1.3	-0.1
Pavlov. Cond. intertrial magazine entries	2.8	3.3	4.7	2.2	1.9	-1.4
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	3.2	-1.8	-1.5	0.2
Pavlov. Cond. response bias	0.7	0.9	1.5	-1.2	-1.1	0.1
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.8	-0.6	0.4
Pavlov. Cond. magazine entry latency	0.4	0.5	1.1	0.1	0.6	-1.0
Pavlov. Cond. change in total contacts	0.9	1.5	1.6	1.2	1.2	-1.2
Pavlov. Cond. index score	0.5	0.7	1.4	0.6	0.6	-1.2
Pavlov. Cond. latency score	0.8	1.1	1.7	0.9	0.9	-1.3
Pavlov. Cond. lever contacts	0.1	0.2	0.3	0.6	0.4	-0.1
Pavlov. Cond. magazine entry number	0.9	1.1	2.4	-0.6	-0.7	1.6
Pavlov. Cond. intertrial magazine entries	1.0	1.6	3.6	-0.5	-0.9	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.8	0.6	0.6	-1.4
Pavlov. Cond. response bias	0.1	0.1	0.1	0.3	0.3	-0.3
Time in closed arm before self-admin	0.1	0.2	0.5	0.2	0.2	0.7
Time in closed arm after self-admin	2.8	3.0	6.5	-0.9	-1.3	2.5
Time in open arm before self-admin	2.3	2.5	3.2	1.6	1.2	-1.8
Time in open arm after self-admin	1.0	1.1	1.4	1.2	1.1	-0.8
Bone: periosteal estimation	0.9	2.0	2.5	-1.6	-1.6	1.0
Bone: periosteal perimeter	1.7	3.0	3.8	-2.0	-1.9	1.3
Bone: post-yield work	0.3	0.4	0.6	-0.7	-0.8	-0.5
Progressive ratio test 1 active lever presses	0.9	1.1	1.8	-1.3	-1.1	0.6
Progressive ratio test 1 breakpoint	1.1	1.4	2.0	-1.4	-1.2	0.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	0.2	0.6	0.1
Progressive ratio test 2 active lever presses	0.5	0.6	1.2	-1.1	-0.5	-0.4
Progressive ratio test 2 breakpoint	0.5	0.5	1.1	-1.0	-0.5	-0.5
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.0	-1.0	-0.6	-0.7
Incentive Sensitization - Responses	0.5	0.7	1.9	0.0	0.5	-1.4
Incentive Sensitization - Breakpoint	0.5	0.6	1.8	-0.2	0.3	-1.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	0.2	0.2	-0.5
Progressive ratio	0.2	0.3	0.6	-0.4	0.3	-0.8
Food seeking constrained by brief footshock	1.6	2.0	5.9	0.4	0.1	-2.4
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.3	-0.4	-0.6
Retroperitoneal fat weight	1.3	5.4	7.6	2.4	2.8	-1.6
Reaction time number correct	0.2	0.4	1.0	0.1	0.4	1.0
Reaction time mean minus median	0.4	1.0	1.3	-0.8	-1.0	-1.1
Reaction time mean minus median AUC	0.2	0.4	0.8	-0.5	-0.5	-0.9
Reaction time num false alarms	1.3	1.8	3.3	-1.4	-0.6	1.8
Reaction time num false alarms AUC	1.2	1.8	3.3	-1.3	-0.5	1.8
Reaction time trials correct on left	0.2	0.4	1.0	0.1	0.4	1.0
Reaction time trials on left	0.2	0.4	1.0	0.1	0.4	1.0
Reaction time mean	0.2	0.3	0.6	-0.5	-0.4	-0.8
Reaction time mean AUC	0.2	0.3	0.4	-0.6	-0.4	-0.6
Median of all reaction times	0.1	0.1	0.3	-0.5	-0.3	-0.2
Reaction time omissions	0.5	0.7	1.3	-1.2	-0.8	0.4
Reaction time false alarm rate	0.5	0.7	1.1	-1.1	-0.5	0.9
Reaction time premature initiation rate	3.2	4.4	4.9	2.2	2.1	-2.0
Reaction time premature initiations	1.5	2.6	3.4	1.8	1.9	-1.0
Std. dev. reaction times	0.3	0.5	1.4	-0.1	0.0	-1.2
Reaction time trials completed	0.2	0.4	1.0	0.1	0.4	1.0
Reaction time trials AUC	0.3	0.6	1.6	-0.1	0.3	1.3
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.2	0.5	0.4
Run reversals in cocaine runway, males	0.7	0.7	1.1	0.8	0.7	-1.0
Latency to leave start box in cocaine runway	4.7	5.4	7.4	-2.5	-2.7	1.6
Latency to leave start box in cocaine runway, F	4.8	5.4	5.9	-2.3	-2.4	2.3
Latency to leave start box in cocaine runway, M	1.1	1.1	1.4	-1.2	-1.1	-0.7
Std. dev. time between licks in bursts	0.4	0.5	1.4	0.3	1.2	0.1
Total sessions with >9 infusions	0.6	0.7	1.1	-1.0	-0.9	0.5
Short access day 1 total inactive lever presses	0.4	0.5	1.0	-0.7	-1.0	0.1
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.1	-0.2	0.1
Short access day 1 total infusions	0.7	0.9	1.0	-0.8	-1.0	-1.0
Short access day 10 total infusions	0.6	0.7	1.3	-1.2	-0.8	0.4
Short access total infusions	0.6	0.7	1.3	-1.1	-1.0	-0.2
Short access day 1 locomotion	0.0	0.0	0.1	0.2	0.2	0.2
Short access day 10 total locomotion	0.3	0.5	0.8	-0.6	-0.9	-0.6
Short access total locomotion	0.1	0.1	0.2	0.3	0.1	-0.4
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.5	-0.2	-0.0
Compulsive drug intake	1.2	1.4	2.5	1.6	1.0	-0.8
One hour access (shock baseline)	0.7	1.0	1.9	-1.4	-0.8	0.7
Social response proportion	3.6	4.1	6.4	2.0	1.4	-2.5
Social responses	6.4	8.2	9.9	3.1	2.8	-2.7
Social time	1.8	2.4	3.5	1.5	1.2	-1.9
Soleus weight	2.7	8.0	14.6	2.4	1.9	-3.8
Bone: stiffness	0.0	0.1	0.1	-0.1	-0.2	-0.4
Tibialis anterior weight	4.4	15.0	17.1	4.1	3.9	-3.6
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.5	0.4	0.7	-1.2
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.4	-0.6	-0.6	-0.3
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.1	0.3	-0.3
Time to tail flick, test, after self-admin	0.8	0.8	2.4	-0.2	0.1	1.5
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.2	-0.4	-0.4	0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.5	0.3	0.5
Tibia length	1.8	5.0	6.6	2.5	2.6	-1.4
Ambulatory time before self-admin	0.1	0.1	0.2	0.0	-0.4	0.2
Ambulatory time after self-admin	0.5	0.6	1.0	1.0	0.5	0.7
Bone: tissue strength	0.3	0.3	0.4	0.6	0.7	0.1
Total heroin consumption	2.2	2.5	3.4	-1.8	-1.8	1.0
Bone: trabecular number	2.4	4.0	5.1	2.3	2.1	-1.5
Bone: trabecular spacing	1.1	1.4	2.4	-1.4	-1.5	0.0
Bone: trabecular thickness	0.7	0.9	1.5	1.2	1.2	-0.1
Bone: trabecular tissue density	0.5	0.7	1.1	-0.9	-1.0	0.3
Water consumed over 24 hours	0.3	0.3	0.7	-0.5	-0.8	-0.3
Number of responses in last shaping day	1.2	1.3	1.4	-1.1	-1.1	1.2