Hub : Genes

Tbc1d22b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Tbc1d22b 0.17 0.12 5.2e-03 0.04 0.05 0.03 0.04 4.9e-03 3.9e-03 2.7e-02 7.9e-03
2 PL gene expression Tbc1d22b 0.14 0.12 2.3e-05 0.04 0.04 0.04 0.04 1.2e-05 2.7e-05 1.2e-05 1.4e-05
3 IL gene expression Tbc1d22b 0.26 0.26 5.4e-03 0.07 0.04 0.07 0.05 7.5e-03 3.5e-02 9.1e-03 2.5e-02
4 Adipose gene expression Tbc1d22b 0.09 0.11 1.1e-03 0.03 0.03 0.02 0.03 4.8e-04 8.0e-04 2.1e-03 5.7e-04
5 OFC gene expression Tbc1d22b 0.15 0.12 1.6e-03 0.1 0.09 0.09 0.1 1.9e-03 3.9e-03 4.4e-03 2.7e-03
6 Brain gene expression Tbc1d22b 0.11 0.08 9.7e-12 0.1 0.11 0.1 0.11 6.3e-10 3.5e-10 5.8e-10 3.3e-10
7 Liver gene expression Tbc1d22b 0.13 0.1 2.2e-16 0.14 0.14 0.14 0.14 2.2e-15 1.6e-15 9.5e-15 9.0e-15
8 NAcc gene expression Tbc1d22b 0.05 0.03 5.8e-08 0.07 0.07 0.08 0.07 1.7e-08 1.3e-08 2.2e-09 4.9e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.61.9-1.41.41.41.41.0-1.3-1.11.1
Area under the delay curve1.11.21.61.1-1.1-0.8-0.9-1.11.11.1-1.3
BMI with tail2.78.811.13.3-3.2-3.1-3.0-2.62.82.8-2.8
BMI without tail1.73.44.12.0-1.9-1.9-1.8-1.72.01.8-1.9
Body weight6.929.131.95.2-5.7-5.5-5.3-5.25.45.4-5.3
Weight adjusted by age3.33.87.52.7-1.8-2.2-2.3-0.91.91.4-1.6
Bone surface0.00.00.10.1-0.00.00.10.2-0.2-0.0-0.1
Bone volume0.00.00.1-0.10.10.20.30.0-0.10.0-0.1
Breakpoint value in progressive ratio session0.30.30.4-0.60.60.40.40.5-0.5-0.60.6
Number of licking bursts0.50.60.7-0.70.80.80.80.8-0.7-0.90.8
Context. condit. distance diff. score0.10.10.3-0.30.40.30.10.4-0.3-0.40.5
Locomotion velocity, session 11.11.22.3-1.51.01.01.10.8-1.2-0.91.1
Locomotion distance, session 13.54.54.9-1.92.22.02.12.2-2.2-2.12.2
Locomotion velocity, session 20.20.30.4-0.40.70.50.50.5-0.6-0.50.5
Locomotion distance, session 20.71.01.3-0.81.10.90.91.2-1.0-1.01.1
Locomotion velocity, session 30.10.10.5-0.4-0.1-0.2-0.2-0.70.30.5-0.1
Locomotion distance, session 30.60.61.0-1.00.80.81.00.5-0.8-0.60.9
Stereotopy head waving bouts, day 31.82.12.71.1-1.3-1.5-1.5-1.61.51.5-1.3
Stereotopy head waving duration, day 30.40.40.80.8-0.6-0.7-0.9-0.40.70.5-0.5
Locomotion velocity, session 70.20.20.5-0.50.70.60.50.1-0.3-0.30.3
Locomotion distance, session 71.21.52.5-1.11.41.41.60.9-1.1-1.11.2
Stereotopy head waving bouts, day 70.20.30.50.0-0.3-0.4-0.7-0.70.50.6-0.4
Stereotopy head waving duration, day 70.81.01.50.6-0.8-0.9-1.2-1.21.01.1-1.0
Locomotion velocity, session 80.00.00.0-0.20.10.00.1-0.00.10.00.1
Locomotion distance, session 80.60.91.2-0.71.10.90.81.1-0.8-1.01.1
Degree of sensitization distance0.10.10.40.6-0.1-0.2-0.30.00.3-0.0-0.3
Degree of sensitization stereotypy0.10.10.6-0.80.50.50.1-0.0-0.2-0.20.3
Conditioned locomotion2.22.63.51.3-1.6-1.5-1.6-1.91.81.7-1.5
Cocaine response after cond. corrected1.92.23.81.9-1.7-1.7-1.6-0.81.21.2-1.3
Cocaine response after cond. not corrected1.71.82.71.6-1.5-1.6-1.5-0.81.11.2-1.3
Cocaine response before conditioning0.20.20.7-0.80.50.50.5-0.2-0.2-0.20.2
Saline control response0.60.81.20.5-0.8-0.8-0.9-1.11.10.9-0.8
Bone: connectivity density0.71.21.4-1.21.11.11.11.0-1.1-1.00.9
Bone: cortical apparent density0.10.10.2-0.40.40.40.40.0-0.3-0.10.1
Bone: cortical area0.71.11.91.4-1.1-1.1-1.0-0.70.90.9-1.1
Bone: cortical porosity0.00.00.10.2-0.3-0.3-0.2-0.00.00.1-0.1
Bone: cortical porosity0.00.00.10.4-0.2-0.2-0.2-0.00.00.1-0.1
Bone: cortical thickness0.00.00.00.10.10.10.10.2-0.1-0.20.0
Bone: cortical thickness0.00.00.10.0-0.0-0.0-0.3-0.30.30.10.0
Bone: cortical tissue density0.00.10.1-0.30.30.30.3-0.0-0.2-0.10.0
Condit. Reinf. active minus inactive responses1.21.31.8-1.31.11.21.01.1-1.3-1.11.1
Condit. Reinf. active-inactive response ratio0.10.10.2-0.30.20.30.20.4-0.4-0.20.3
Condit. Reinf. active responses0.60.81.7-1.30.81.00.80.5-0.9-0.70.8
Condit. Reinf. inactive responses0.80.92.0-1.41.01.11.00.4-0.9-0.70.9
Incentive salience index mean0.50.60.9-0.90.70.90.60.7-0.9-0.70.7
Condit. Reinf. lever presses0.00.00.1-0.10.10.30.00.3-0.3-0.20.1
Condit. Reinf. active minus inactive responses1.11.32.4-1.51.00.91.01.1-1.2-1.01.3
Condit. Reinf. active-inactive response ratio0.30.30.7-0.80.30.30.30.8-0.6-0.60.7
Condit. Reinf. active responses1.01.42.5-1.61.11.11.11.0-1.2-1.01.4
Condit. Reinf. inactive responses0.10.10.2-0.50.20.20.3-0.3-0.10.10.2
Condit. Reinf. lever presses4.15.67.2-2.52.32.32.32.1-2.4-2.22.7
Condit. Reinf. lever reinforcers received1.82.63.8-1.91.51.51.51.4-1.6-1.41.8
Conditioned reinforcement - actives0.60.60.80.6-0.9-0.9-0.9-0.80.80.8-0.5
Conditioned reinforcement - inactives0.30.40.8-0.90.60.60.60.2-0.5-0.50.7
Conditioned locomotion0.70.81.10.9-1.1-0.9-0.9-0.91.00.9-0.8
Patch foraging indifference point 0 sec0.30.50.70.8-0.7-0.7-0.7-0.70.80.7-0.7
Patch foraging indifference point AUC0.10.10.2-0.50.20.20.30.1-0.1-0.20.4
Delay disc. indifference point, 0s delay1.11.22.71.6-1.4-1.1-1.1-0.21.00.7-0.8
Delay disc. indifference point, 16s delay0.10.10.3-0.50.00.20.2-0.5-0.00.4-0.3
Delay disc. indifference point, 2s delay0.10.10.40.6-0.20.0-0.00.20.0-0.1-0.1
Delay disc. indifference point, 24s delay2.42.33.31.3-1.4-1.3-1.4-1.61.51.7-1.8
Delay disc. indifference point, 4s delay1.71.82.11.5-1.3-1.4-1.4-1.21.31.3-1.4
Delay disc. indifference point, 8s delay1.71.72.41.1-1.3-1.1-1.1-1.61.41.4-1.5
Indifference point function ln k0.10.10.30.10.20.30.30.5-0.3-0.40.1
Indifference point function log k0.10.10.30.10.20.30.30.5-0.3-0.40.1
Patch foraging total patch changes 0 sec0.30.50.70.8-0.7-0.7-0.6-0.70.80.6-0.7
Patch foraging total patch changes 12 sec0.00.00.0-0.0-0.2-0.1-0.0-0.10.10.00.2
Patch foraging total patch changes 18 sec0.40.51.30.4-0.5-0.6-0.4-1.20.70.8-0.5
Patch foraging total patch changes 24 sec0.20.20.4-0.30.30.30.40.6-0.6-0.50.6
Patch foraging total patch changes 6 sec0.10.10.20.3-0.4-0.4-0.2-0.20.50.3-0.2
Patch foraging time to switch 0 sec1.32.02.71.2-1.6-1.6-1.6-1.31.21.5-1.2
Patch foraging water rate 0 sec0.10.20.40.40.40.40.40.6-0.2-0.60.2
Patch foraging water rate 12 sec0.10.20.4-0.20.60.50.60.6-0.2-0.50.4
Patch foraging water rate 18 sec0.91.31.7-1.11.31.31.30.9-1.1-1.01.0
Patch foraging water rate 24 sec0.30.50.9-0.30.90.80.80.7-0.5-0.60.5
Patch foraging water rate 6 sec0.10.10.3-0.00.50.40.40.4-0.1-0.40.3
Seeking ratio, delayed vs. immediate footshock0.60.72.2-1.50.91.10.9-0.2-0.7-0.30.3
Distance traveled before self-admin0.91.01.21.0-1.1-1.0-1.0-1.00.90.9-0.9
Distance traveled after self-admin0.00.10.10.2-0.2-0.2-0.2-0.30.20.1-0.3
Extensor digitorum longus weight0.20.81.0-0.90.90.81.00.8-0.8-0.91.0
Bone: elastic displacement0.10.10.1-0.40.20.20.20.2-0.3-0.20.1
Bone: elastic work0.10.10.20.4-0.3-0.3-0.2-0.20.30.3-0.4
Bone: endosteal estimation3.57.58.22.7-2.9-2.8-2.7-2.72.62.8-2.7
Bone: endosteal perimeter2.34.95.92.3-2.4-2.4-2.2-1.82.12.2-2.2
Epididymis fat weight2.14.85.62.1-2.3-2.4-2.3-1.92.42.1-2.1
Delta time in closed arm before/after self-admin3.23.14.12.0-2.0-2.0-2.0-1.31.81.5-1.4
Delta time in open arm before/after self-admin1.01.01.2-1.01.01.11.10.9-1.1-0.90.9
Diff in mean of infusions in LGA sessions0.80.91.2-0.81.00.90.91.1-0.9-1.01.0
Delay discount exponential model param0.80.91.3-0.90.90.70.81.0-0.9-1.01.1
Extinction: sum of active levers before priming0.10.10.30.0-0.2-0.4-0.40.4-0.0-0.30.5
Active lever presses in extinction session 60.00.00.1-0.1-0.2-0.1-0.10.00.00.2-0.1
Bone: final force4.87.78.12.8-2.8-2.8-2.8-2.72.72.8-2.8
Bone: final moment4.16.77.02.6-2.6-2.6-2.6-2.62.52.7-2.6
Food consumed during 24 hour testing period0.70.91.11.0-1.0-1.0-1.1-0.70.90.8-1.0
Glucose0.30.41.11.1-0.7-0.8-0.7-0.00.50.4-0.7
Heart weight1.62.33.5-1.01.31.61.51.9-1.6-1.81.3
Delay discount hyperbolic model param0.60.60.9-0.90.80.60.60.8-0.8-0.81.0
Intermittent access intake day 1-15 change0.20.21.0-0.60.10.00.0-1.00.30.5-0.3
Intermittent access intake escalation0.40.41.5-0.5-0.2-0.2-0.2-1.20.50.8-0.5
Intermittent access intake escalation 20.70.72.0-1.40.90.90.90.1-0.7-0.50.7
Intermitt. access day 1 inactive lever presses0.20.20.60.8-0.5-0.5-0.50.20.3-0.10.0
Intermitt. access day 15 inactive lever presses0.50.61.7-0.1-0.6-0.6-0.6-1.30.80.9-0.7
Intermitt. access escalation Index0.40.30.5-0.40.60.60.60.7-0.6-0.60.4
Intermittent access day 1 total infusions0.30.40.5-0.70.60.60.60.5-0.6-0.60.6
Intermittent access day 15 total infusions0.10.10.3-0.50.10.10.1-0.4-0.00.10.0
Intermittent access terminal intake (last 3 days)0.10.10.30.1-0.4-0.3-0.3-0.50.40.4-0.3
Intermittent access total infusions0.10.10.3-0.50.40.40.40.1-0.4-0.30.3
Intermittent access day 1 locomotion0.20.20.30.4-0.5-0.5-0.5-0.50.50.4-0.3
Intermittent access day 15 total locomotion2.83.06.40.6-1.6-1.5-1.5-2.51.82.0-1.7
Intermittent access total locomotion0.91.02.80.1-0.8-0.7-0.7-1.71.01.2-1.0
Intermittent access standard deviation0.91.01.20.9-1.1-1.1-1.1-1.01.00.9-0.8
Left kidney weight2.77.69.02.5-3.0-2.8-2.7-2.92.62.9-2.7
Right kidney weight3.49.511.62.7-3.2-3.0-2.9-3.43.03.2-3.1
Cocaine induced anxiety0.40.51.0-1.00.80.80.80.1-0.6-0.50.5
Post-drug Anxiety0.60.71.2-1.10.80.90.90.5-0.8-0.70.8
Baseline Anxiety0.10.10.40.6-0.2-0.3-0.30.60.0-0.20.1
Tail length1.03.03.91.5-1.6-1.7-1.5-2.02.01.8-1.8
Length with tail2.07.49.02.2-2.7-2.7-2.5-3.02.92.9-2.8
Length without tail1.63.64.31.6-2.1-1.9-1.9-1.91.92.0-1.9
Times rat made contact with spout4.14.75.7-2.42.22.22.21.9-2.0-2.02.3
Lifetime Intake0.00.00.10.1-0.2-0.2-0.2-0.30.10.2-0.1
Liver weight, left3.75.910.41.8-2.1-2.2-2.1-3.22.62.8-2.3
Liver weight, right2.03.45.01.6-1.7-1.7-1.6-2.22.01.9-1.8
Locomotor activity0.10.20.70.4-0.1-0.1-0.3-0.60.80.3-0.3
Locomotor testing distance0.10.20.70.8-0.1-0.3-0.4-0.20.80.1-0.4
Locomotor testing rearing1.11.82.51.4-1.1-1.2-1.2-1.51.61.3-1.3
Locomotion in novel chamber0.20.20.50.30.40.30.50.7-0.5-0.60.2
Locomotion in novel chamber post-restriction1.82.22.51.5-1.4-1.5-1.5-1.51.41.6-1.5
Fecal boli incidents, locomotor time 10.00.00.10.00.10.30.2-0.1-0.10.1-0.2
Change in fecal boli incidents, locomotor task2.82.66.32.5-1.7-2.0-2.0-0.31.50.8-0.9
Time >=10cm from walls, locomotor time 12.92.94.52.1-1.6-2.0-2.0-1.11.61.4-1.5
Bouts of movement, locomotor time 10.50.50.8-0.90.70.90.80.5-0.8-0.50.5
Total resting periods, locomotor time 10.30.30.7-0.80.50.60.60.1-0.5-0.30.3
Rest time, locomotor task time 10.20.20.40.6-0.6-0.4-0.4-0.30.30.4-0.5
Distance moved, locomotor task time 10.10.10.2-0.1-0.3-0.4-0.3-0.30.40.3-0.1
Vertical activity count, locomotor time 10.40.40.50.4-0.7-0.7-0.6-0.70.70.7-0.6
Time >=10cm from walls, locomotor time 211.211.918.04.2-3.4-3.8-3.9-2.43.52.9-3.1
Bouts of movement, locomotor time 20.10.10.2-0.50.4-0.00.1-0.3-0.10.2-0.1
Total resting periods, locomotor time 20.10.10.4-0.50.70.30.30.2-0.4-0.20.3
Rest time, locomotor task time 20.00.10.20.3-0.5-0.1-0.2-0.10.10.1-0.2
Distance moved, locomotor task time 22.02.43.41.3-1.4-1.8-1.7-1.61.61.5-1.3
Vertical activity count, locomotor time 21.21.31.91.2-0.8-1.4-1.3-1.11.21.1-1.1
Light reinforcement 12.34.14.92.0-2.0-2.1-2.2-2.02.22.0-1.8
Light reinforcement 22.33.03.51.7-1.7-1.7-1.7-1.81.61.9-1.7
Bone: marrow area3.67.88.42.7-2.9-2.9-2.7-2.82.72.9-2.8
Bone: maximum diameter0.81.52.31.5-1.4-1.3-1.2-0.81.01.1-1.3
Bone: maximum force1.83.23.41.8-1.8-1.8-1.7-1.71.71.8-1.8
Bone: maximum moment1.42.42.71.6-1.6-1.6-1.5-1.51.51.6-1.6
Mean time between licks in bursts0.60.81.2-0.90.90.90.91.1-1.0-0.90.7
Mean num. licks in bursts0.40.50.8-0.90.70.70.70.5-0.7-0.50.7
Cd content in liver0.50.61.00.4-0.7-0.6-0.6-1.00.71.0-0.9
Co content in liver2.63.03.71.7-1.8-1.9-1.7-1.61.81.7-1.6
Cu content in liver3.03.64.4-1.52.02.01.82.1-1.7-2.11.9
Fe content in liver3.34.04.61.6-1.9-2.1-1.9-2.12.02.2-2.1
K content in liver1.01.01.8-0.60.81.00.81.3-1.0-1.11.0
Mg content in liver1.71.73.3-0.81.11.21.11.8-1.4-1.51.4
Mn content in liver0.00.00.20.20.00.1-0.20.4-0.1-0.20.2
Na content in liver0.20.20.5-0.70.40.50.30.5-0.6-0.50.5
Rb content in liver0.20.30.40.6-0.6-0.5-0.6-0.50.50.5-0.5
Se content in liver2.32.84.6-1.31.61.71.52.1-1.6-1.91.6
Sr content in liver0.00.00.00.10.00.00.00.1-0.0-0.10.1
Zn content in liver3.13.57.42.7-1.9-1.8-1.9-1.21.91.4-1.6
Bone: minimum diameter2.44.46.32.5-2.3-2.3-2.2-1.51.91.9-2.1
Time in familiar zone, hab. session 10.10.10.4-0.60.10.30.2-0.1-0.2-0.10.3
Time in novel zone, hab. session 10.50.51.21.1-0.6-0.7-0.7-0.40.70.6-0.8
Total zone transitions, hab. session 13.04.25.0-2.12.12.01.91.9-2.0-2.12.2
Total locomotion distance, hab. session 11.92.73.3-1.71.71.61.41.6-1.5-1.71.8
Locomotion velocity, hab. session 11.72.43.1-1.51.61.41.31.5-1.4-1.61.8
Time in familiar zone, hab. session 21.21.21.7-0.81.31.21.21.0-1.1-1.11.0
Time in novel zone, hab. session 21.01.01.50.5-1.1-1.1-1.0-1.11.01.2-0.8
Total zone transitions, hab. session 20.30.40.6-0.30.80.60.50.8-0.6-0.70.7
Total locomotion distance, hab. session 22.12.83.5-1.31.91.71.51.8-1.6-1.71.9
Locomotion velocity, hab. session 22.53.44.2-1.42.11.81.62.0-1.8-2.02.0
Novel to familiar place preference ratio0.70.81.20.9-1.0-1.0-1.1-0.60.90.7-0.7
Novelty place preference0.60.61.00.8-0.9-0.9-1.0-0.60.80.6-0.6
Time in novel zone, NPP test0.60.61.00.7-0.9-0.9-1.0-0.60.70.7-0.6
Total zone transitions, NPP test1.31.92.5-0.91.41.31.31.6-1.5-1.41.5
Total locomotion distance, NPP test1.01.31.8-0.61.21.11.01.3-1.2-1.21.3
Locomotion velocity, NPP test1.42.02.8-0.71.51.41.31.7-1.4-1.61.5
Intraocular pressure0.81.11.70.7-1.1-0.9-0.8-1.21.11.3-1.0
Delta distance traveled before/after self-admin0.60.60.7-0.80.80.80.80.8-0.6-0.80.8
Delta ambulatory time before/after self-admin0.91.01.2-1.01.11.11.10.8-0.9-1.00.9
Parametrial fat weight1.01.94.80.3-1.2-1.1-0.8-2.21.41.7-1.3
Pavlov. Cond. lever latency0.20.30.60.2-0.5-0.6-0.4-0.80.60.7-0.4
Pavlov. Cond. magazine entry latency0.30.40.6-0.30.50.70.60.8-0.7-0.60.6
Pavlov. Cond. change in total contacts0.30.30.50.2-0.7-0.5-0.5-0.70.50.7-0.6
Pavlov. Cond. index score0.10.10.20.20.10.30.20.5-0.2-0.30.1
Pavlov. Cond. latency score0.00.00.20.4-0.00.1-0.10.40.0-0.2-0.0
Pavlov. Cond. lever contacts0.10.20.4-0.20.40.40.30.6-0.4-0.50.3
Pavlov. Cond. magazine entry number0.70.91.50.6-0.8-0.9-1.0-1.21.10.9-0.9
Pavlov. Cond. intertrial magazine entries0.20.20.7-0.90.40.40.30.1-0.5-0.30.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.20.10.20.20.4-0.2-0.20.1
Pavlov. Cond. response bias1.01.21.5-1.00.91.11.11.2-1.2-1.01.1
Pavlov. Cond. lever latency2.63.64.42.1-2.0-2.0-2.0-1.51.81.6-2.1
Pavlov. Cond. magazine entry latency0.10.10.3-0.3-0.1-0.0-0.1-0.50.20.3-0.1
Pavlov. Cond. change in total contacts1.92.63.6-1.91.71.61.61.3-1.5-1.41.8
Pavlov. Cond. index score1.01.32.3-1.51.21.21.20.7-1.0-0.81.3
Pavlov. Cond. latency score0.70.81.6-1.30.90.90.90.5-0.8-0.61.0
Pavlov. Cond. lever contacts2.33.14.7-2.21.91.91.91.1-1.6-1.42.0
Pavlov. Cond. magazine entry number0.00.00.20.4-0.2-0.2-0.10.30.0-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.60.81.2-0.60.90.81.01.1-0.9-0.90.9
Pavlov. Cond. lever-magazine prob. diff.0.60.81.7-1.31.01.01.00.4-0.8-0.61.0
Pavlov. Cond. response bias1.62.23.8-2.01.61.61.50.8-1.3-1.11.7
Time in closed arm before self-admin0.10.20.60.40.20.10.10.8-0.2-0.50.3
Time in closed arm after self-admin0.60.61.31.1-0.9-0.9-0.9-0.10.80.5-0.5
Time in open arm before self-admin1.31.43.2-1.81.41.31.30.3-1.1-0.80.9
Time in open arm after self-admin3.84.26.1-2.52.32.32.31.3-2.1-1.71.7
Bone: periosteal estimation2.75.66.32.5-2.5-2.5-2.3-2.22.22.4-2.3
Bone: periosteal perimeter1.42.32.91.7-1.7-1.7-1.5-1.11.41.5-1.5
Bone: post-yield work0.20.30.50.5-0.6-0.6-0.7-0.30.50.6-0.4
Progressive ratio test 1 active lever presses0.00.00.10.1-0.1-0.2-0.20.00.10.00.1
Progressive ratio test 1 breakpoint0.10.10.10.4-0.3-0.4-0.40.10.20.00.1
Progressive ratio test 1 inactive lever presses0.70.81.20.3-1.0-0.9-0.9-1.10.90.9-0.7
Progressive ratio test 2 active lever presses0.10.10.5-0.70.10.10.1-0.0-0.1-0.10.4
Progressive ratio test 2 breakpoint0.10.10.5-0.70.30.20.20.1-0.2-0.10.5
Progressive ratio test 2 inactive lever presses0.80.92.0-1.40.90.90.90.4-0.9-0.81.0
Incentive Sensitization - Responses1.71.73.2-1.81.31.31.31.0-1.3-1.11.4
Incentive Sensitization - Breakpoint1.31.32.9-1.71.21.11.10.7-1.1-0.91.1
Sum of active levers in priming session hrs 5-60.30.30.5-0.60.40.40.40.6-0.7-0.70.7
Progressive ratio1.61.83.90.5-1.0-1.0-1.1-2.01.41.7-1.5
Food seeking constrained by brief footshock0.00.00.1-0.00.30.20.20.3-0.1-0.20.1
Seeking ratio, punishment vs. effort0.70.92.90.10.50.50.61.7-0.9-1.31.0
Retroperitoneal fat weight1.75.76.82.4-2.6-2.5-2.4-2.22.62.3-2.2
Reaction time number correct0.20.31.0-0.2-0.5-0.3-0.2-1.00.40.8-0.4
Reaction time mean minus median0.20.31.2-1.10.60.50.5-0.4-0.40.10.4
Reaction time mean minus median AUC0.10.20.6-0.80.30.30.4-0.4-0.30.20.2
Reaction time num false alarms0.20.20.3-0.50.40.60.50.1-0.5-0.50.4
Reaction time num false alarms AUC0.60.81.1-0.80.81.00.90.7-0.9-1.00.8
Reaction time trials correct on left0.20.31.0-0.2-0.5-0.3-0.2-1.00.40.8-0.4
Reaction time trials on left0.20.30.9-0.3-0.5-0.3-0.2-1.00.40.7-0.4
Reaction time mean0.10.10.30.1-0.2-0.4-0.4-0.50.40.5-0.2
Reaction time mean AUC0.30.40.70.2-0.4-0.6-0.5-0.90.70.8-0.4
Median of all reaction times0.30.40.60.6-0.6-0.8-0.8-0.50.70.7-0.4
Reaction time omissions0.30.41.3-1.10.60.70.8-0.0-0.4-0.20.5
Reaction time false alarm rate0.81.11.9-0.51.01.00.91.3-1.1-1.40.9
Reaction time premature initiation rate0.10.10.20.00.10.10.10.5-0.2-0.40.4
Reaction time premature initiations0.00.00.10.0-0.3-0.2-0.1-0.20.20.10.0
Std. dev. reaction times0.10.20.6-0.80.50.40.4-0.1-0.2-0.00.4
Reaction time trials completed0.20.30.9-0.3-0.5-0.3-0.2-1.00.40.7-0.4
Reaction time trials AUC0.20.30.9-0.3-0.5-0.3-0.2-0.90.40.7-0.4
Run reversals in cocaine runway, females0.10.10.3-0.40.10.10.0-0.6-0.00.3-0.2
Run reversals in cocaine runway, males1.11.13.4-1.91.31.11.2-0.6-0.6-0.20.3
Latency to leave start box in cocaine runway0.40.51.10.9-0.7-0.8-0.81.00.2-0.30.3
Latency to leave start box in cocaine runway, F0.40.41.10.9-0.5-0.8-0.81.00.1-0.20.3
Latency to leave start box in cocaine runway, M0.20.10.40.6-0.5-0.5-0.40.10.40.0-0.1
Std. dev. time between licks in bursts1.61.93.92.0-1.6-1.6-1.5-0.51.20.9-1.2
Total sessions with >9 infusions0.10.20.30.5-0.5-0.5-0.5-0.20.40.3-0.1
Short access day 1 total inactive lever presses0.10.10.1-0.30.30.20.20.3-0.2-0.30.3
Short access day 10 total inactive lever presses0.00.00.1-0.20.0-0.0-0.0-0.30.10.00.0
Short access day 1 total infusions0.50.60.9-0.40.60.60.60.9-0.8-0.90.9
Short access day 10 total infusions0.00.00.0-0.00.00.10.10.0-0.1-0.20.1
Short access total infusions0.10.10.20.5-0.4-0.4-0.4-0.10.20.1-0.1
Short access day 1 locomotion0.20.20.40.6-0.6-0.6-0.60.10.30.10.1
Short access day 10 total locomotion0.40.41.21.1-0.7-0.6-0.60.60.3-0.30.4
Short access total locomotion0.60.71.81.3-1.0-1.0-1.0-0.10.70.3-0.3
One hour access (0.3 mA shock)1.21.42.1-1.41.21.11.11.0-1.2-1.11.3
Compulsive drug intake1.21.23.3-0.20.70.70.71.8-1.1-1.51.3
One hour access (shock baseline)0.20.31.2-1.10.40.50.5-0.6-0.20.20.1
Social response proportion0.40.51.91.4-0.7-0.5-0.5-0.10.40.3-0.7
Social responses0.10.10.70.8-0.4-0.4-0.40.10.10.0-0.1
Social time0.30.40.8-0.90.40.60.60.4-0.7-0.50.6
Soleus weight0.82.33.71.9-1.6-1.6-1.5-0.91.51.1-1.5
Bone: stiffness1.32.12.41.4-1.5-1.4-1.3-1.51.41.5-1.4
Tibialis anterior weight0.72.23.0-1.41.31.31.51.7-1.5-1.61.7
Time to tail flick, vehicle, before self-admin0.90.92.7-0.0-0.5-0.5-0.5-1.61.01.2-1.1
Time to tail flick, vehicle, after self-admin0.10.10.20.4-0.1-0.1-0.10.4-0.1-0.20.1
Time to tail flick, test, before self-admin0.30.30.4-0.70.40.60.60.3-0.5-0.40.4
Time to tail flick, test, after self-admin0.80.82.0-1.41.30.90.9-0.1-0.7-0.30.4
Delta time to tail flick, vehicle, before/after SA0.50.51.70.20.40.30.31.3-0.8-0.80.7
Delta time to tail flick, test, before/after SA0.90.81.60.5-0.4-0.8-0.8-1.30.91.1-1.0
Tibia length2.05.76.82.0-2.4-2.4-2.3-2.62.32.6-2.5
Ambulatory time before self-admin0.30.40.60.5-0.7-0.6-0.6-0.60.50.6-0.6
Ambulatory time after self-admin0.30.40.6-0.80.70.70.70.2-0.5-0.60.4
Bone: tissue strength0.00.00.00.10.10.10.2-0.0-0.0-0.00.0
Total heroin consumption1.31.63.0-1.71.31.41.40.6-1.1-1.11.2
Bone: trabecular number1.52.32.8-1.61.61.71.51.4-1.4-1.41.3
Bone: trabecular spacing2.33.03.81.9-1.7-1.7-1.6-1.81.81.6-1.7
Bone: trabecular thickness0.10.10.4-0.2-0.1-0.10.0-0.60.20.5-0.3
Bone: trabecular tissue density0.10.10.3-0.50.20.30.3-0.1-0.20.00.3
Water consumed over 24 hours0.81.01.9-0.70.80.90.81.4-1.0-1.20.9
Number of responses in last shaping day0.50.51.51.2-0.7-0.6-0.61.00.1-0.50.4