Hub : Genes

Tbc1d22b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Tbc1d22b 0.17 0.1 1.5e-05 0.04 0.06 0.05 0.05 1.7e-04 1.4e-05 1.2e-04 9.5e-05
2 Adipose gene expression Tbc1d22b 0.13 0.13 4.8e-04 0.03 0.03 0.03 0.03 3.2e-04 2.6e-04 5.8e-04 3.4e-04
3 PL gene expression Tbc1d22b 0.04 0.03 1.5e-04 0.04 0.03 0.04 0.04 1.8e-05 4.0e-04 5.6e-05 4.0e-05
4 Brain gene expression Tbc1d22b 0.12 0.09 1.0e-10 0.1 0.09 0.09 0.1 3.0e-09 4.1e-09 9.9e-09 3.8e-09
5 Liver gene expression Tbc1d22b 0.13 0.1 1.7e-16 0.14 0.14 0.14 0.14 1.2e-15 1.0e-15 3.3e-15 4.6e-15
6 NAcc isoform ratio NM_001025059.1 0.01 0.01 9.1e-03 0.01 0.01 0.01 0.01 2.2e-03 9.0e-03 5.6e-03 6.3e-03
7 NAcc gene expression Tbc1d22b 0.06 0.04 4.5e-08 0.04 0.05 0.05 0.05 4.6e-07 1.0e-07 1.5e-07 7.5e-08
8 OFC gene expression Tbc1d22b 0.16 0.12 1.1e-03 0.12 0.12 0.11 0.12 8.1e-04 1.1e-03 1.2e-03 7.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.81.42.2-1.3-1.3-1.4-1.5-1.10.8-1.2-0.8
Area under the delay curve0.91.01.50.90.91.00.91.1-0.91.21.2
BMI with tail2.79.411.33.33.33.43.13.1-2.63.02.7
BMI without tail2.37.07.92.62.72.72.82.7-2.52.62.5
Body weight5.725.027.74.54.95.15.35.2-5.24.75.0
Weight adjusted by age2.33.46.82.62.51.82.21.3-0.91.90.7
Bone surface0.00.00.10.10.1-0.0-0.30.0-0.10.1-0.0
Bone volume0.00.00.1-0.1-0.0-0.1-0.30.1-0.30.10.3
Breakpoint value in progressive ratio session0.10.10.3-0.5-0.4-0.4-0.1-0.2-0.0-0.5-0.2
Number of licking bursts0.30.50.7-0.6-0.6-0.8-0.8-0.80.7-0.7-0.6
Context. condit. distance diff. score0.20.30.7-0.3-0.4-0.4-0.1-0.40.7-0.5-0.8
Locomotion velocity, session 11.31.42.6-1.6-1.4-0.9-1.3-0.90.8-1.5-0.8
Locomotion distance, session 13.54.55.1-1.9-2.1-2.2-2.2-2.12.1-2.2-2.1
Locomotion velocity, session 20.20.30.3-0.5-0.5-0.6-0.5-0.60.6-0.5-0.5
Locomotion distance, session 20.81.11.6-0.8-0.9-1.1-1.1-1.11.2-1.2-1.0
Locomotion velocity, session 30.20.20.7-0.6-0.30.1-0.00.5-0.8-0.20.6
Locomotion distance, session 30.60.61.1-1.0-1.0-0.8-1.0-0.50.5-0.9-0.4
Stereotopy head waving bouts, day 31.72.02.51.11.31.41.61.6-1.61.21.5
Stereotopy head waving duration, day 30.40.50.90.90.90.71.00.5-0.30.60.2
Locomotion velocity, session 70.20.20.6-0.5-0.5-0.8-0.4-0.30.1-0.3-0.1
Locomotion distance, session 71.01.22.3-1.0-1.1-1.5-1.2-1.10.9-1.1-0.8
Stereotopy head waving bouts, day 70.60.71.60.20.40.70.81.0-1.20.71.1
Stereotopy head waving duration, day 70.70.81.70.50.60.80.81.1-1.30.81.1
Locomotion velocity, session 80.00.00.1-0.2-0.2-0.10.1-0.00.1-0.2-0.1
Locomotion distance, session 80.71.01.7-0.7-0.8-1.1-0.7-1.01.2-1.0-1.3
Degree of sensitization distance0.20.20.60.80.60.10.60.00.10.50.0
Degree of sensitization stereotypy0.20.20.7-0.8-0.6-0.5-0.3-0.2-0.2-0.4-0.0
Conditioned locomotion2.22.53.61.31.51.31.91.6-1.81.51.6
Cocaine response after cond. corrected1.82.24.02.01.81.61.51.3-0.71.60.7
Cocaine response after cond. not corrected1.51.72.71.71.61.61.31.2-0.71.40.8
Cocaine response before conditioning0.20.30.9-0.9-0.8-0.3-0.5-0.1-0.1-0.50.4
Saline control response0.40.50.90.40.40.70.90.7-0.80.50.9
Bone: connectivity density0.60.91.4-1.1-1.0-1.1-1.2-0.90.6-0.9-0.7
Bone: cortical apparent density0.10.20.3-0.6-0.6-0.4-0.4-0.30.1-0.4-0.2
Bone: cortical area0.50.71.21.11.00.90.80.7-0.21.00.7
Bone: cortical porosity0.00.00.00.10.20.20.10.00.00.10.1
Bone: cortical porosity0.00.00.10.30.30.20.10.10.10.20.1
Bone: cortical thickness0.10.20.7-0.3-0.4-0.4-0.4-0.50.8-0.4-0.3
Bone: cortical thickness0.00.00.1-0.2-0.2-0.10.20.00.0-0.30.3
Bone: cortical tissue density0.10.10.2-0.5-0.5-0.3-0.3-0.2-0.0-0.3-0.2
Condit. Reinf. active minus inactive responses1.11.31.7-1.3-1.3-0.9-1.1-1.10.9-1.3-1.0
Condit. Reinf. active-inactive response ratio0.10.10.1-0.3-0.3-0.0-0.3-0.20.3-0.3-0.3
Condit. Reinf. active responses0.60.81.7-1.3-1.1-0.7-1.0-0.70.3-1.0-0.4
Condit. Reinf. inactive responses0.81.02.2-1.5-1.3-1.0-1.0-0.80.3-1.1-0.3
Incentive salience index mean0.50.60.8-0.9-0.9-0.6-0.8-0.70.5-0.9-0.7
Condit. Reinf. lever presses0.00.00.0-0.0-0.10.0-0.0-0.10.0-0.1-0.1
Condit. Reinf. active minus inactive responses1.11.42.5-1.6-1.3-0.9-1.4-0.90.8-1.4-0.6
Condit. Reinf. active-inactive response ratio0.30.30.7-0.9-0.6-0.3-0.6-0.50.4-0.8-0.4
Condit. Reinf. active responses1.01.52.6-1.6-1.5-1.0-1.3-0.90.9-1.5-0.5
Condit. Reinf. inactive responses0.10.10.2-0.5-0.5-0.1-0.30.1-0.1-0.30.4
Condit. Reinf. lever presses4.46.17.5-2.6-2.7-2.3-2.6-2.32.5-2.7-2.1
Condit. Reinf. lever reinforcers received1.82.63.9-2.0-1.9-1.4-1.7-1.31.4-1.9-1.0
Conditioned reinforcement - actives0.20.30.60.00.20.50.50.8-0.70.20.8
Conditioned reinforcement - inactives0.00.10.2-0.4-0.3-0.2-0.2-0.20.1-0.4-0.0
Conditioned locomotion1.01.32.00.60.81.21.11.3-1.40.91.4
Patch foraging indifference point 0 sec0.30.60.90.80.70.70.80.7-0.60.81.0
Patch foraging indifference point AUC0.20.30.4-0.6-0.6-0.6-0.4-0.50.5-0.6-0.6
Delay disc. indifference point, 0s delay0.91.02.21.51.21.21.10.7-0.11.00.3
Delay disc. indifference point, 16s delay0.20.20.5-0.7-0.5-0.1-0.20.4-0.50.10.7
Delay disc. indifference point, 2s delay0.10.10.40.60.40.10.0-0.20.50.3-0.2
Delay disc. indifference point, 24s delay1.82.02.51.11.21.41.31.6-1.51.51.6
Delay disc. indifference point, 4s delay1.51.61.91.31.31.21.21.3-1.11.41.2
Delay disc. indifference point, 8s delay1.51.72.91.11.11.21.21.5-1.31.41.7
Indifference point function ln k0.00.00.10.10.00.0-0.2-0.30.3-0.0-0.3
Indifference point function log k0.00.00.10.10.00.0-0.2-0.30.3-0.0-0.3
Patch foraging total patch changes 0 sec0.40.70.91.00.80.70.80.7-0.50.90.9
Patch foraging total patch changes 12 sec0.00.00.00.10.00.10.10.10.20.00.1
Patch foraging total patch changes 18 sec0.30.51.10.60.50.50.60.9-0.70.71.1
Patch foraging total patch changes 24 sec0.10.20.5-0.0-0.2-0.3-0.6-0.50.7-0.2-0.5
Patch foraging total patch changes 6 sec0.10.10.20.40.40.50.50.4-0.20.40.4
Patch foraging time to switch 0 sec0.71.32.11.01.21.40.91.4-1.10.91.2
Patch foraging water rate 0 sec0.10.20.40.60.4-0.20.3-0.40.40.4-0.5
Patch foraging water rate 12 sec0.00.10.3-0.2-0.2-0.50.2-0.40.3-0.2-0.3
Patch foraging water rate 18 sec0.40.61.0-1.0-1.0-0.9-0.8-0.70.5-0.7-0.4
Patch foraging water rate 24 sec0.20.30.7-0.4-0.6-0.9-0.2-0.60.6-0.4-0.6
Patch foraging water rate 6 sec0.10.10.30.20.0-0.60.4-0.40.20.0-0.4
Seeking ratio, delayed vs. immediate footshock0.81.02.9-1.7-1.4-0.8-1.2-0.3-0.3-0.70.2
Distance traveled before self-admin0.70.91.10.80.90.90.91.0-1.00.91.0
Distance traveled after self-admin0.10.10.30.10.2-0.00.30.2-0.60.30.5
Extensor digitorum longus weight0.20.91.1-0.9-0.9-0.9-0.9-1.01.0-1.0-1.0
Bone: elastic displacement0.10.10.2-0.4-0.4-0.1-0.3-0.10.2-0.3-0.0
Bone: elastic work0.10.10.10.30.30.30.30.30.00.30.3
Bone: endosteal estimation3.26.97.82.62.72.82.42.8-2.62.82.4
Bone: endosteal perimeter2.24.75.82.32.32.42.22.2-1.82.31.8
Epididymis fat weight0.72.53.41.41.51.81.81.7-1.31.41.5
Delta time in closed arm before/after self-admin4.13.85.62.32.32.12.41.8-1.21.91.4
Delta time in open arm before/after self-admin1.31.32.0-1.4-1.4-1.2-1.3-1.00.7-1.1-0.7
Diff in mean of infusions in LGA sessions0.30.31.0-0.0-0.2-0.5-0.2-0.70.7-0.4-1.0
Delay discount exponential model param0.70.81.3-0.8-0.8-0.8-0.8-1.00.8-1.1-1.1
Extinction: sum of active levers before priming0.20.20.50.50.60.70.60.10.3-0.2-0.2
Active lever presses in extinction session 60.10.10.3-0.6-0.50.2-0.20.10.1-0.4-0.1
Bone: final force3.96.37.02.52.52.62.32.6-2.32.72.4
Bone: final moment3.35.36.12.42.32.42.12.4-2.02.52.2
Food consumed during 24 hour testing period0.81.12.11.11.11.41.01.0-0.70.90.9
Glucose0.30.51.41.21.00.70.60.20.30.7-0.1
Heart weight0.50.82.40.2-0.0-0.7-0.3-1.21.5-0.4-1.4
Delay discount hyperbolic model param0.50.60.8-0.8-0.7-0.7-0.6-0.80.6-0.9-0.9
Intermittent access intake day 1-15 change0.20.41.2-0.4-0.10.30.30.7-1.00.21.1
Intermittent access intake escalation0.20.41.4-0.7-0.40.10.10.7-1.10.11.2
Intermittent access intake escalation 20.40.41.4-1.2-0.9-0.4-0.5-0.1-0.5-0.50.5
Intermitt. access day 1 inactive lever presses0.20.61.60.1-0.0-0.4-0.4-1.01.2-0.7-1.3
Intermitt. access day 15 inactive lever presses0.10.31.0-0.4-0.10.00.10.5-1.00.10.9
Intermitt. access escalation Index0.40.50.7-0.6-0.7-0.8-0.7-0.80.8-0.5-0.8
Intermittent access day 1 total infusions0.60.91.2-1.1-1.1-1.1-1.0-0.80.8-1.0-0.8
Intermittent access day 15 total infusions0.30.41.2-1.1-0.9-0.7-0.7-0.1-0.2-0.50.2
Intermittent access terminal intake (last 3 days)0.10.10.2-0.5-0.3-0.2-0.20.1-0.3-0.20.3
Intermittent access total infusions0.40.51.0-1.0-0.9-0.8-0.8-0.40.2-0.7-0.2
Intermittent access day 1 locomotion0.10.10.20.10.10.10.20.4-0.50.30.5
Intermittent access day 15 total locomotion1.73.17.4-0.10.61.51.42.1-2.71.02.7
Intermittent access total locomotion0.60.71.9-0.7-0.30.30.20.9-1.30.11.4
Intermittent access standard deviation0.81.61.91.11.21.11.31.4-1.31.21.3
Left kidney weight2.913.315.93.23.43.63.63.9-4.03.54.0
Right kidney weight4.922.227.84.04.34.54.55.1-5.34.65.2
Cocaine induced anxiety0.10.20.4-0.5-0.5-0.6-0.6-0.50.1-0.4-0.1
Post-drug Anxiety0.50.50.9-0.9-0.8-0.8-0.9-0.70.3-0.7-0.3
Baseline Anxiety0.30.30.80.90.70.60.60.30.20.4-0.2
Tail length0.72.95.31.11.41.31.91.8-2.31.62.0
Length with tail1.87.912.52.02.42.63.13.0-3.52.53.2
Length without tail3.19.911.82.83.03.43.43.3-3.22.83.1
Times rat made contact with spout4.04.65.6-2.4-2.4-2.2-2.2-2.01.7-2.4-1.8
Lifetime Intake0.10.10.2-0.4-0.4-0.3-0.30.1-0.2-0.20.2
Liver weight, left1.83.04.02.01.91.51.71.8-1.61.71.6
Liver weight, right3.05.26.62.62.52.22.22.3-2.12.42.1
Locomotor activity0.10.20.70.40.30.10.80.3-0.30.30.2
Locomotor testing distance0.20.41.50.90.70.31.20.20.10.40.0
Locomotor testing rearing0.81.62.41.41.31.21.51.2-1.11.21.1
Locomotion in novel chamber0.20.20.60.3-0.0-0.4-0.4-0.50.80.1-0.7
Locomotion in novel chamber post-restriction1.52.52.81.61.61.61.31.7-1.61.61.6
Fecal boli incidents, locomotor time 10.00.10.20.30.2-0.10.00.2-0.20.50.1
Change in fecal boli incidents, locomotor task3.73.67.62.72.62.22.31.2-0.51.60.7
Time >=10cm from walls, locomotor time 12.93.15.22.32.31.72.01.5-1.11.71.1
Bouts of movement, locomotor time 10.50.51.1-0.9-0.9-0.7-1.0-0.50.4-0.7-0.4
Total resting periods, locomotor time 10.30.30.8-0.9-0.7-0.5-0.8-0.20.0-0.5-0.0
Rest time, locomotor task time 10.30.30.70.70.70.90.40.4-0.30.60.3
Distance moved, locomotor task time 10.00.10.2-0.00.10.40.40.3-0.30.00.2
Vertical activity count, locomotor time 10.20.50.70.50.60.80.80.8-0.90.60.7
Time >=10cm from walls, locomotor time 27.811.518.54.34.23.43.82.9-2.23.42.2
Bouts of movement, locomotor time 20.10.10.3-0.6-0.4-0.5-0.20.1-0.2-0.30.2
Total resting periods, locomotor time 20.10.20.5-0.6-0.5-0.7-0.4-0.20.2-0.5-0.2
Rest time, locomotor task time 20.10.10.20.30.30.50.10.10.00.20.1
Distance moved, locomotor task time 21.92.32.71.31.61.51.61.7-1.61.21.5
Vertical activity count, locomotor time 21.01.42.01.31.41.11.41.1-1.11.11.0
Light reinforcement 11.53.74.52.02.11.72.11.9-1.81.91.9
Light reinforcement 21.82.73.41.71.61.51.21.8-1.71.71.7
Bone: marrow area3.37.28.12.62.72.92.52.8-2.62.82.5
Bone: maximum diameter0.61.21.91.41.31.21.01.0-0.61.20.9
Bone: maximum force1.32.32.81.61.61.61.41.6-1.31.71.4
Bone: maximum moment1.01.82.21.51.41.41.21.4-1.01.51.2
Mean time between licks in bursts0.41.11.8-0.9-1.0-0.8-1.3-1.11.0-0.8-1.3
Mean num. licks in bursts0.30.50.8-0.9-0.9-0.7-0.7-0.60.5-0.9-0.6
Cd content in liver0.00.00.1-0.4-0.2-0.2-0.0-0.0-0.3-0.10.2
Co content in liver2.22.63.31.61.71.61.81.5-1.61.51.5
Cu content in liver2.52.94.2-1.3-1.4-2.0-1.3-2.01.8-1.6-2.1
Fe content in liver1.51.82.81.01.21.21.31.4-1.71.31.5
K content in liver0.60.61.0-0.4-0.5-0.8-0.6-0.90.9-0.7-1.0
Mg content in liver0.60.61.3-0.2-0.4-0.7-0.6-0.91.1-0.6-1.1
Mn content in liver0.10.10.20.40.30.10.30.1-0.00.3-0.1
Na content in liver0.30.30.5-0.7-0.6-0.7-0.7-0.50.1-0.7-0.3
Rb content in liver0.00.00.10.30.20.00.10.10.20.10.1
Se content in liver1.21.42.0-0.8-1.0-1.4-0.9-1.41.3-1.1-1.4
Sr content in liver0.00.00.0-0.2-0.1-0.1-0.0-0.10.1-0.1-0.0
Zn content in liver0.30.31.10.3-0.0-0.30.1-0.51.0-0.3-0.9
Bone: minimum diameter2.24.15.92.42.32.32.01.9-1.22.31.5
Time in familiar zone, hab. session 10.20.20.5-0.7-0.6-0.1-0.3-0.10.1-0.6-0.1
Time in novel zone, hab. session 10.70.71.41.21.10.60.80.6-0.61.00.5
Total zone transitions, hab. session 13.14.35.6-2.2-2.1-2.2-2.0-2.11.9-2.4-1.8
Total locomotion distance, hab. session 11.92.73.6-1.7-1.6-1.6-1.4-1.71.6-1.9-1.5
Locomotion velocity, hab. session 11.72.43.2-1.5-1.5-1.5-1.3-1.61.5-1.8-1.5
Time in familiar zone, hab. session 21.21.32.1-0.7-0.9-1.4-0.9-1.21.3-1.0-1.5
Time in novel zone, hab. session 21.11.12.40.40.71.20.71.3-1.30.71.6
Total zone transitions, hab. session 20.30.40.7-0.3-0.4-0.8-0.5-0.70.7-0.6-0.7
Total locomotion distance, hab. session 22.12.73.7-1.2-1.4-1.9-1.4-1.71.8-1.7-1.8
Locomotion velocity, hab. session 22.43.34.5-1.3-1.5-2.1-1.6-2.02.0-1.8-2.0
Novel to familiar place preference ratio0.60.71.10.91.01.01.00.7-0.50.70.5
Novelty place preference0.50.50.80.80.80.90.90.6-0.50.60.4
Time in novel zone, NPP test0.40.50.90.60.71.00.70.7-0.60.50.5
Total zone transitions, NPP test1.21.72.5-0.8-1.0-1.5-1.2-1.41.6-1.3-1.4
Total locomotion distance, NPP test0.91.32.1-0.5-0.8-1.4-1.0-1.31.4-1.1-1.3
Locomotion velocity, NPP test1.31.93.2-0.6-0.9-1.7-1.0-1.61.8-1.2-1.7
Intraocular pressure0.60.91.60.50.51.00.81.3-1.20.91.2
Delta distance traveled before/after self-admin0.30.30.5-0.4-0.4-0.6-0.3-0.70.7-0.6-0.7
Delta ambulatory time before/after self-admin0.30.40.7-0.6-0.5-0.8-0.5-0.80.5-0.5-0.6
Parametrial fat weight2.04.69.80.61.11.82.02.6-3.11.53.1
Pavlov. Cond. lever latency0.20.30.50.30.40.50.40.7-0.70.50.6
Pavlov. Cond. magazine entry latency0.30.40.8-0.4-0.6-0.6-0.6-0.60.9-0.7-0.6
Pavlov. Cond. change in total contacts0.40.40.80.10.30.80.60.8-0.80.40.9
Pavlov. Cond. index score0.00.10.30.2-0.0-0.10.0-0.20.5-0.1-0.3
Pavlov. Cond. latency score0.10.10.20.50.20.10.4-0.10.40.1-0.2
Pavlov. Cond. lever contacts0.00.00.10.10.0-0.00.0-0.30.3-0.1-0.2
Pavlov. Cond. magazine entry number0.60.71.40.50.70.70.90.8-1.20.80.9
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.9-0.6-0.3-0.6-0.3-0.1-0.6-0.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.20.2-0.0-0.1-0.0-0.20.4-0.1-0.3
Pavlov. Cond. response bias0.70.91.1-0.9-1.0-0.8-1.0-0.91.0-1.0-0.9
Pavlov. Cond. lever latency2.53.45.02.12.21.81.71.6-1.72.11.2
Pavlov. Cond. magazine entry latency0.10.20.8-0.4-0.30.3-0.10.4-0.4-0.10.9
Pavlov. Cond. change in total contacts1.32.13.4-1.8-1.8-1.5-1.3-1.21.2-1.7-0.8
Pavlov. Cond. index score0.81.02.0-1.4-1.4-0.8-1.0-0.70.7-1.3-0.3
Pavlov. Cond. latency score0.50.71.5-1.2-1.2-0.6-0.8-0.60.5-1.1-0.2
Pavlov. Cond. lever contacts2.12.84.3-2.0-2.1-1.7-1.5-1.51.5-2.0-1.0
Pavlov. Cond. magazine entry number0.10.10.20.40.40.00.2-0.10.20.2-0.5
Pavlov. Cond. intertrial magazine entries0.50.71.4-0.6-0.7-1.0-0.6-0.90.9-0.8-1.2
Pavlov. Cond. lever-magazine prob. diff.0.60.81.6-1.3-1.2-0.7-0.8-0.60.5-1.1-0.1
Pavlov. Cond. response bias1.31.83.2-1.8-1.8-1.3-1.2-1.00.9-1.6-0.5
Time in closed arm before self-admin0.20.30.80.30.1-0.5-0.2-0.70.9-0.3-0.9
Time in closed arm after self-admin0.70.71.91.41.20.71.20.30.40.6-0.3
Time in open arm before self-admin0.30.30.6-0.7-0.7-0.6-0.6-0.40.1-0.5-0.2
Time in open arm after self-admin1.82.03.7-1.9-1.8-1.7-1.7-1.20.5-1.3-0.6
Bone: periosteal estimation2.14.35.22.22.22.31.92.1-1.72.21.9
Bone: periosteal perimeter1.01.72.21.51.41.51.31.3-0.91.41.1
Bone: post-yield work0.20.30.40.60.60.60.40.6-0.50.60.5
Progressive ratio test 1 active lever presses0.10.10.20.50.50.20.40.20.10.1-0.0
Progressive ratio test 1 breakpoint0.10.10.30.50.50.10.30.10.20.1-0.2
Progressive ratio test 1 inactive lever presses0.20.30.8-0.00.30.60.40.7-0.80.30.9
Progressive ratio test 2 active lever presses0.10.20.6-0.8-0.6-0.2-0.20.1-0.0-0.60.1
Progressive ratio test 2 breakpoint0.20.20.8-0.9-0.7-0.3-0.3-0.00.1-0.70.1
Progressive ratio test 2 inactive lever presses0.20.30.7-0.8-0.6-0.5-0.6-0.30.1-0.6-0.0
Incentive Sensitization - Responses1.21.72.8-1.7-1.6-1.3-1.3-1.01.0-1.5-0.9
Incentive Sensitization - Breakpoint1.01.32.6-1.6-1.5-1.2-1.2-0.80.7-1.3-0.6
Sum of active levers in priming session hrs 5-60.30.30.6-0.7-0.5-0.4-0.7-0.40.1-0.7-0.2
Progressive ratio1.32.04.30.40.71.21.11.7-2.01.12.1
Food seeking constrained by brief footshock0.10.10.3-0.1-0.3-0.4-0.2-0.20.5-0.2-0.4
Seeking ratio, punishment vs. effort0.71.03.00.1-0.2-0.6-0.5-1.21.6-0.6-1.7
Retroperitoneal fat weight0.83.65.21.31.42.02.22.1-2.11.62.3
Reaction time number correct0.20.41.2-0.5-0.20.40.10.7-1.10.11.0
Reaction time mean minus median0.20.41.1-1.0-0.8-0.5-0.50.1-0.6-0.60.5
Reaction time mean minus median AUC0.10.20.5-0.7-0.7-0.3-0.30.3-0.5-0.30.5
Reaction time num false alarms0.20.30.5-0.6-0.6-0.7-0.7-0.70.4-0.6-0.4
Reaction time num false alarms AUC0.71.11.5-0.9-0.9-1.2-1.1-1.21.0-1.0-1.0
Reaction time trials correct on left0.20.41.2-0.5-0.20.40.10.7-1.10.11.0
Reaction time trials on left0.20.41.2-0.5-0.30.40.10.7-1.10.11.0
Reaction time mean0.10.20.30.10.20.20.40.6-0.50.10.6
Reaction time mean AUC0.20.40.80.20.20.40.60.9-0.80.30.9
Median of all reaction times0.20.30.50.50.50.40.60.7-0.50.40.6
Reaction time omissions0.10.20.6-0.7-0.6-0.2-0.10.1-0.3-0.40.3
Reaction time false alarm rate0.91.32.4-0.4-0.6-1.2-1.0-1.51.6-0.9-1.5
Reaction time premature initiation rate0.10.10.2-0.1-0.0-0.2-0.1-0.40.5-0.4-0.3
Reaction time premature initiations0.00.00.2-0.2-0.00.20.10.1-0.3-0.20.4
Std. dev. reaction times0.10.20.5-0.7-0.6-0.5-0.20.0-0.3-0.60.2
Reaction time trials completed0.20.41.2-0.5-0.30.40.10.7-1.10.11.0
Reaction time trials AUC0.20.41.2-0.5-0.30.40.10.7-1.10.10.9
Run reversals in cocaine runway, females0.10.10.2-0.3-0.20.2-0.20.4-0.30.10.5
Run reversals in cocaine runway, males1.31.33.9-2.0-1.5-1.1-1.2-0.1-0.9-0.70.8
Latency to leave start box in cocaine runway0.50.51.80.60.60.40.5-0.51.0-0.3-1.3
Latency to leave start box in cocaine runway, F0.40.51.50.60.50.40.6-0.30.9-0.3-1.2
Latency to leave start box in cocaine runway, M0.20.20.60.70.70.50.5-0.10.10.3-0.2
Std. dev. time between licks in bursts1.41.94.22.01.81.71.31.1-0.21.40.4
Total sessions with >9 infusions0.00.00.0-0.1-0.1-0.1-0.1-0.00.2-0.2-0.1
Short access day 1 total inactive lever presses0.10.10.3-0.5-0.3-0.1-0.20.1-0.5-0.20.4
Short access day 10 total inactive lever presses0.40.91.2-1.1-1.0-1.1-1.1-0.90.6-0.9-0.6
Short access day 1 total infusions0.10.20.4-0.2-0.2-0.3-0.4-0.50.5-0.5-0.6
Short access day 10 total infusions0.60.81.6-1.3-1.2-1.1-1.1-0.50.2-0.7-0.2
Short access total infusions0.00.00.0-0.2-0.2-0.1-0.10.0-0.0-0.2-0.0
Short access day 1 locomotion0.10.10.20.40.30.30.2-0.10.40.0-0.4
Short access day 10 total locomotion0.40.72.01.41.30.80.8-0.10.40.4-0.5
Short access total locomotion0.40.51.41.21.10.80.70.20.10.5-0.1
One hour access (0.3 mA shock)2.63.03.8-1.8-1.8-1.7-1.7-1.61.7-2.0-1.6
Compulsive drug intake1.11.33.0-0.3-0.4-0.8-0.9-1.51.6-1.0-1.7
One hour access (shock baseline)0.61.02.7-1.6-1.5-1.0-1.0-0.2-0.0-0.90.1
Social response proportion0.70.82.51.61.20.70.50.20.11.1-0.2
Social responses0.20.20.70.90.70.50.20.10.30.4-0.3
Social time0.30.40.7-0.8-0.7-0.6-0.7-0.50.3-0.7-0.4
Soleus weight0.92.64.52.12.01.71.71.3-0.81.81.0
Bone: stiffness1.01.72.01.41.31.31.21.4-1.21.41.3
Tibialis anterior weight0.51.92.2-1.3-1.3-1.2-1.3-1.41.4-1.5-1.5
Time to tail flick, vehicle, before self-admin1.01.13.1-0.4-0.10.50.41.2-1.70.71.8
Time to tail flick, vehicle, after self-admin0.30.40.8-0.1-0.3-0.8-0.5-0.70.8-0.4-0.9
Time to tail flick, test, before self-admin0.60.61.0-0.9-1.0-0.6-0.9-0.70.7-0.7-0.7
Time to tail flick, test, after self-admin1.51.63.4-1.8-1.7-1.7-1.5-0.50.1-1.00.0
Delta time to tail flick, vehicle, before/after SA1.71.63.4-0.3-0.7-1.2-1.1-1.41.8-1.0-1.9
Delta time to tail flick, test, before/after SA0.40.41.10.30.40.10.40.8-1.00.61.0
Tibia length2.15.78.71.92.22.32.12.5-3.02.42.5
Ambulatory time before self-admin0.10.10.20.10.20.40.40.4-0.40.20.4
Ambulatory time after self-admin0.10.10.5-0.6-0.4-0.7-0.2-0.4-0.1-0.30.0
Bone: tissue strength0.00.00.10.30.20.10.00.1-0.00.30.0
Total heroin consumption1.21.42.4-1.6-1.4-1.2-1.3-1.20.5-1.2-0.8
Bone: trabecular number1.11.82.4-1.5-1.5-1.5-1.4-1.31.0-1.3-1.1
Bone: trabecular spacing2.22.93.51.91.81.71.91.6-1.51.81.4
Bone: trabecular thickness0.20.21.0-0.2-0.10.10.10.5-0.70.21.0
Bone: trabecular tissue density0.10.20.4-0.7-0.5-0.4-0.5-0.1-0.3-0.30.1
Water consumed over 24 hours0.60.81.4-0.7-0.7-0.6-0.9-1.01.2-1.0-1.0
Number of responses in last shaping day1.51.74.82.21.91.31.2-0.00.71.0-0.6