Hub : Genes

Tbc1d22a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Tbc1d22a	0.03	0.03	8.4e-03	0.01	0.01	0.01	0.01	6.6e-02	1.4e-02	1.6e-02	3.0e-02
2	Adipose	mRNA stability	Tbc1d22a	0.04	0.02	1.1e-05	0.03	0.04	0.04	0.03	1.4e-04	7.6e-05	8.6e-05	1.4e-04
3	Liver	gene expression	Tbc1d22a	0.15	0.08	0.0e+00	0.14	0.12	0.13	0.13	2.5e-15	1.6e-13	5.5e-14	1.0e-14
4	Adipose	gene expression	Tbc1d22a	0.1	0.05	1.3e-14	0.11	0.11	0.11	0.11	4.6e-12	4.8e-12	3.8e-12	4.4e-12
5	RMTg	mRNA stability	Tbc1d22a	0.12	0.09	8.5e-03	-0	0.03	0.01	0.01	4.4e-01	6.0e-02	2.2e-01	1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.5	0.9	1.0	1.0	1.0	-0.9	1.0	0.8
Area under the delay curve	5.1	5.4	6.0	2.4	2.4	-2.4	2.5	1.9
BMI with tail	3.4	11.0	12.5	-2.5	-3.4	3.5	-3.5	-3.5
BMI without tail	1.3	2.7	4.2	-2.0	-1.8	1.4	-1.8	-0.9
Body weight	2.6	11.1	12.8	-3.5	-3.6	3.4	-3.6	-2.4
Weight adjusted by age	1.8	2.1	2.6	-1.2	-1.4	1.6	-1.5	-1.5
Bone surface	0.2	0.4	0.5	0.5	0.7	-0.7	0.6	0.6
Bone volume	0.4	0.7	0.9	0.7	0.9	-0.9	0.9	0.9
Breakpoint value in progressive ratio session	0.2	0.2	0.6	0.8	0.2	-0.0	0.0	-0.6
Number of licking bursts	0.4	0.5	1.5	-0.0	0.5	-0.6	0.5	1.2
Context. condit. distance diff. score	1.0	1.2	1.4	-1.0	-1.2	1.1	-1.2	-1.1
Locomotion velocity, session 1	1.1	1.2	2.7	-1.7	-1.1	0.8	-1.0	-0.1
Locomotion distance, session 1	0.5	0.6	1.3	0.1	0.6	-0.9	0.7	1.1
Locomotion velocity, session 2	3.3	3.9	6.3	-2.5	-2.1	1.9	-2.1	-0.8
Locomotion distance, session 2	0.2	0.2	0.5	0.7	0.5	-0.4	0.4	0.1
Locomotion velocity, session 3	1.7	2.0	5.3	-2.3	-1.3	1.0	-1.3	0.4
Locomotion distance, session 3	0.3	0.3	1.1	-0.7	-0.0	-0.1	0.0	1.1
Stereotopy head waving bouts, day 3	0.3	0.4	0.6	-0.7	-0.7	0.4	-0.7	-0.5
Stereotopy head waving duration, day 3	1.0	1.2	1.6	-1.1	-1.2	0.8	-1.3	-1.0
Locomotion velocity, session 7	0.8	0.9	1.9	-1.4	-1.0	0.6	-1.0	-0.1
Locomotion distance, session 7	0.3	0.3	0.7	-0.9	-0.6	0.6	-0.6	0.1
Stereotopy head waving bouts, day 7	0.8	0.9	1.3	-1.2	-1.0	0.8	-1.1	-0.6
Stereotopy head waving duration, day 7	0.2	0.3	0.5	-0.7	-0.6	0.4	-0.6	-0.2
Locomotion velocity, session 8	5.4	6.4	7.2	-2.3	-2.7	2.7	-2.6	-2.3
Locomotion distance, session 8	0.5	0.7	0.9	-1.0	-0.9	0.8	-0.8	-0.5
Degree of sensitization distance	1.4	1.4	2.3	-0.6	-1.2	1.3	-1.2	-1.5
Degree of sensitization stereotypy	0.5	0.6	0.8	-0.9	-0.8	0.7	-0.8	-0.5
Conditioned locomotion	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.4	-0.2
Cocaine response after cond. corrected	0.4	0.5	1.0	-1.0	-0.7	0.8	-0.6	0.0
Cocaine response after cond. not corrected	0.3	0.3	1.0	-1.0	-0.4	0.4	-0.4	0.6
Cocaine response before conditioning	0.4	0.5	0.9	0.3	0.6	-0.8	0.7	0.9
Saline control response	0.3	0.4	0.6	-0.6	-0.7	0.8	-0.5	-0.5
Bone: connectivity density	0.3	0.5	0.7	0.5	0.8	-0.7	0.7	0.9
Bone: cortical apparent density	1.2	1.6	2.3	1.5	1.4	-1.2	1.3	0.8
Bone: cortical area	1.6	2.4	3.2	-1.1	-1.6	1.6	-1.6	-1.8
Bone: cortical porosity	2.1	2.3	3.3	-1.1	-1.5	1.8	-1.4	-1.7
Bone: cortical porosity	1.9	2.1	2.9	-1.0	-1.4	1.7	-1.3	-1.6
Bone: cortical thickness	0.1	0.2	0.6	0.4	-0.1	0.4	-0.1	-0.8
Bone: cortical thickness	2.2	2.5	4.8	-0.6	-1.5	1.8	-1.5	-2.2
Bone: cortical tissue density	0.9	1.2	1.9	1.4	1.2	-1.1	1.2	0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.3	0.4	-0.4	0.7	0.4
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.9	1.1	1.1	-1.1	1.4	0.9
Condit. Reinf. active responses	0.7	0.9	1.6	0.3	0.8	-0.9	1.1	1.3
Condit. Reinf. inactive responses	0.2	0.3	1.0	-0.4	0.2	-0.4	0.3	1.0
Incentive salience index mean	0.2	0.2	0.8	-0.9	-0.4	0.2	-0.0	0.3
Condit. Reinf. lever presses	1.2	1.5	4.1	-2.0	-1.3	1.0	-1.0	0.1
Condit. Reinf. active minus inactive responses	0.5	0.6	0.9	-0.6	-0.8	0.8	-0.7	-1.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.3	-0.3	0.2	-0.2	-0.4
Condit. Reinf. active responses	1.7	2.3	2.9	-1.3	-1.6	1.5	-1.5	-1.7
Condit. Reinf. inactive responses	2.9	3.5	4.0	-1.6	-2.0	1.9	-2.0	-1.9
Condit. Reinf. lever presses	0.5	0.7	0.9	-0.7	-0.9	0.6	-0.9	-1.0
Condit. Reinf. lever reinforcers received	1.2	1.6	2.1	-1.0	-1.3	1.3	-1.3	-1.5
Conditioned reinforcement - actives	0.3	0.3	0.6	-0.8	-0.2	0.2	-0.1	0.7
Conditioned reinforcement - inactives	1.1	1.2	2.1	-1.2	-1.1	1.4	-1.0	-0.6
Conditioned locomotion	2.3	2.7	4.2	-2.1	-1.8	1.6	-1.6	-1.0
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	0.1
Patch foraging indifference point AUC	0.3	0.4	0.5	0.5	0.6	-0.7	0.7	0.5
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.0	-0.1	0.4	-0.1	0.0
Delay disc. indifference point, 16s delay	5.2	5.2	6.2	2.5	2.5	-2.3	2.3	1.8
Delay disc. indifference point, 2s delay	0.8	0.9	1.2	1.1	0.9	-1.0	1.1	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.6	0.2	-0.2	0.4	-0.3
Delay disc. indifference point, 4s delay	7.0	7.4	8.5	2.8	2.9	-2.9	2.8	2.0
Delay disc. indifference point, 8s delay	4.7	4.9	5.7	2.4	2.3	-2.3	2.3	1.7
Indifference point function ln k	3.5	4.8	5.7	-2.3	-2.3	2.4	-2.3	-1.5
Indifference point function log k	3.5	4.8	5.7	-2.3	-2.3	2.4	-2.3	-1.5
Patch foraging total patch changes 0 sec	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.3
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.1	0.0	-0.2	0.1	-0.1
Patch foraging total patch changes 18 sec	0.6	0.7	1.0	0.5	0.8	-0.9	0.9	1.0
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.1	0.3	-0.4	0.3	0.5
Patch foraging total patch changes 6 sec	0.6	0.9	1.1	1.0	1.0	-1.0	1.0	0.6
Patch foraging time to switch 0 sec	0.3	0.5	1.0	1.0	0.7	-0.8	0.6	0.1
Patch foraging water rate 0 sec	0.3	0.6	0.7	-0.7	-0.8	0.7	-0.7	-0.8
Patch foraging water rate 12 sec	0.7	1.1	2.1	-1.4	-1.0	1.2	-1.0	-0.1
Patch foraging water rate 18 sec	0.1	0.2	0.5	-0.7	-0.4	0.2	-0.2	-0.1
Patch foraging water rate 24 sec	0.7	1.0	1.5	-0.8	-1.1	1.2	-0.9	-1.0
Patch foraging water rate 6 sec	0.1	0.2	0.7	-0.6	0.0	-0.0	0.2	0.8
Seeking ratio, delayed vs. immediate footshock	1.0	1.1	1.8	1.3	1.2	-1.0	1.0	0.7
Distance traveled before self-admin	0.2	0.2	0.6	-0.8	-0.5	0.3	-0.4	0.1
Distance traveled after self-admin	1.1	1.2	1.4	-0.9	-1.1	1.2	-1.1	-1.1
Extensor digitorum longus weight	0.5	1.9	2.4	-1.4	-1.5	1.5	-1.5	-1.0
Bone: elastic displacement	0.5	0.5	1.2	-1.1	-0.8	0.6	-0.7	-0.0
Bone: elastic work	3.6	4.7	5.3	-1.9	-2.3	2.3	-2.2	-2.1
Bone: endosteal estimation	2.0	4.3	5.1	-2.1	-2.2	1.9	-2.3	-1.8
Bone: endosteal perimeter	3.2	6.7	7.8	-2.7	-2.8	2.5	-2.8	-2.1
Epididymis fat weight	0.5	1.2	1.8	-1.2	-1.1	1.4	-1.0	-0.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.3	-0.0	0.2	-0.1	-0.5
Delta time in open arm before/after self-admin	0.4	0.4	1.1	-0.6	0.1	-0.6	0.2	1.0
Diff in mean of infusions in LGA sessions	0.5	0.6	1.8	0.2	-0.5	0.7	-0.6	-1.3
Delay discount exponential model param	5.3	5.6	6.2	-2.4	-2.5	2.5	-2.5	-1.9
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.6	0.3	-0.0	0.3	-0.2
Active lever presses in extinction session 6	1.2	1.1	2.3	-0.3	-0.9	1.1	-1.1	-1.5
Bone: final force	1.1	1.8	4.6	-0.1	-1.1	1.3	-1.2	-2.1
Bone: final moment	1.4	2.2	5.7	-0.2	-1.2	1.4	-1.3	-2.4
Food consumed during 24 hour testing period	4.8	5.8	6.7	-2.3	-2.6	2.4	-2.4	-2.3
Glucose	0.0	0.0	0.1	0.3	0.0	0.2	0.2	-0.3
Heart weight	0.3	0.4	1.1	1.1	0.7	-0.6	0.4	-0.1
Delay discount hyperbolic model param	4.9	5.2	5.9	-2.3	-2.4	2.4	-2.4	-1.8
Intermittent access intake day 1-15 change	0.5	0.5	0.9	-0.9	-0.8	1.0	-0.5	-0.5
Intermittent access intake escalation	1.3	1.2	1.8	-1.2	-1.2	1.4	-0.9	-0.8
Intermittent access intake escalation 2	0.2	0.2	0.5	-0.2	-0.4	0.7	-0.1	-0.6
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.8	0.4	-0.4	0.6	-0.6	-1.3
Intermitt. access day 15 inactive lever presses	3.3	3.6	5.6	-1.2	-1.9	2.0	-1.9	-2.4
Intermitt. access escalation Index	0.5	0.4	0.6	-0.6	-0.7	0.8	-0.7	-0.5
Intermittent access day 1 total infusions	3.3	3.8	5.9	-2.4	-2.0	2.1	-1.9	-0.8
Intermittent access day 15 total infusions	4.4	4.9	6.7	-2.6	-2.3	2.6	-2.1	-1.2
Intermittent access terminal intake (last 3 days)	6.8	7.5	10.2	-3.0	-2.9	3.2	-2.6	-1.8
Intermittent access total infusions	5.9	6.5	9.0	-2.8	-2.7	3.0	-2.5	-1.6
Intermittent access day 1 locomotion	1.7	1.7	3.3	-1.8	-1.3	1.4	-1.3	-0.1
Intermittent access day 15 total locomotion	3.5	3.8	6.5	-2.6	-2.1	1.9	-1.9	-0.7
Intermittent access total locomotion	3.7	4.2	5.5	-2.3	-2.2	2.3	-2.0	-1.2
Intermittent access standard deviation	1.3	1.3	2.3	-0.8	-1.1	1.5	-1.0	-1.3
Left kidney weight	12.3	34.5	40.2	-5.4	-6.2	5.9	-6.3	-5.4
Right kidney weight	12.1	34.1	38.7	-5.0	-6.1	6.0	-6.2	-5.7
Cocaine induced anxiety	2.1	2.4	4.9	-0.4	-1.4	1.7	-1.5	-2.2
Post-drug Anxiety	1.7	1.9	5.8	0.5	-0.9	1.3	-1.1	-2.4
Baseline Anxiety	0.8	0.9	1.0	0.9	1.0	-1.0	1.0	0.8
Tail length	0.5	1.5	4.6	-0.7	0.6	-1.3	0.8	2.2
Length with tail	0.4	1.6	3.9	-2.0	-1.3	1.1	-1.1	0.2
Length without tail	1.9	4.1	6.3	-1.6	-2.1	2.5	-1.9	-1.9
Times rat made contact with spout	0.5	0.5	1.3	-1.1	-0.7	0.5	-0.8	0.1
Lifetime Intake	5.6	6.4	8.4	-2.9	-2.7	2.9	-2.4	-1.4
Liver weight, left	0.3	0.6	0.8	-0.4	-0.7	0.9	-0.8	-0.8
Liver weight, right	0.9	1.4	3.4	-1.8	-1.2	1.1	-1.1	0.3
Locomotor activity	3.2	5.0	7.5	-2.7	-2.4	2.2	-2.4	-1.2
Locomotor testing distance	0.5	0.8	1.6	-1.3	-1.0	0.8	-1.0	-0.3
Locomotor testing rearing	0.8	1.3	2.5	-1.6	-1.2	0.9	-1.3	-0.3
Locomotion in novel chamber	1.2	1.5	3.6	-0.4	0.7	-1.6	0.8	1.9
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.3	0.2	-0.5	0.1	-0.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.2	-0.2	0.1	-0.5	-0.1
Change in fecal boli incidents, locomotor task	0.6	0.6	1.0	0.2	0.7	-1.0	0.8	0.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.2	-0.1	-0.0	-0.2	-0.5
Bouts of movement, locomotor time 1	0.7	0.7	0.9	-0.7	-0.9	1.0	-0.8	-0.9
Total resting periods, locomotor time 1	0.3	0.4	1.0	-0.1	-0.5	0.6	-0.5	-1.0
Rest time, locomotor task time 1	0.4	0.4	0.6	-0.7	-0.6	0.5	-0.8	-0.6
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.1	-0.2	-0.0	-0.1	-0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.3	0.5	0.2	-0.3	0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.3	-0.2	-0.6	0.9	-0.6	-1.1
Bouts of movement, locomotor time 2	1.0	1.1	2.4	1.6	1.1	-0.9	1.1	0.2
Total resting periods, locomotor time 2	1.0	1.1	2.3	1.5	1.1	-0.9	1.1	0.3
Rest time, locomotor task time 2	2.8	3.2	6.7	0.6	1.7	-1.9	1.6	2.6
Distance moved, locomotor task time 2	3.6	4.2	4.9	-1.6	-2.2	2.2	-2.1	-2.2
Vertical activity count, locomotor time 2	3.8	4.2	5.9	-1.4	-2.2	2.2	-1.9	-2.4
Light reinforcement 1	0.4	0.7	1.9	-1.4	-0.9	0.4	-0.8	0.0
Light reinforcement 2	3.9	5.3	6.1	-2.4	-2.5	2.4	-2.4	-1.7
Bone: marrow area	2.0	4.3	5.1	-2.1	-2.2	2.0	-2.3	-1.8
Bone: maximum diameter	6.3	11.7	13.1	-3.1	-3.6	3.5	-3.6	-3.3
Bone: maximum force	1.4	2.4	6.3	-0.1	-1.3	1.5	-1.4	-2.5
Bone: maximum moment	1.7	2.9	7.5	-0.2	-1.4	1.6	-1.5	-2.7
Mean time between licks in bursts	1.2	1.7	2.5	0.8	1.3	-1.6	1.3	1.4
Mean num. licks in bursts	1.4	1.7	2.4	-0.9	-1.3	1.3	-1.3	-1.6
Cd content in liver	0.1	0.1	0.3	0.6	0.4	-0.3	0.4	-0.0
Co content in liver	0.7	0.8	1.5	-1.2	-1.0	0.7	-0.9	-0.4
Cu content in liver	7.5	9.1	10.3	3.2	3.2	-3.1	3.1	2.4
Fe content in liver	0.3	0.4	0.6	-0.5	-0.7	0.8	-0.6	-0.6
K content in liver	0.2	0.2	0.6	0.5	-0.1	0.4	-0.1	-0.8
Mg content in liver	0.2	0.2	0.5	0.6	-0.0	0.4	-0.0	-0.7
Mn content in liver	1.3	1.5	2.6	-1.6	-1.3	1.2	-1.3	-0.4
Na content in liver	2.6	2.7	4.3	2.1	1.8	-1.4	1.7	1.0
Rb content in liver	0.6	0.8	1.7	1.3	0.9	-0.8	0.8	-0.1
Se content in liver	0.1	0.1	0.2	-0.4	-0.1	0.0	0.0	0.4
Sr content in liver	2.4	2.2	3.6	0.4	1.3	-1.9	1.4	1.9
Zn content in liver	0.9	1.0	1.3	0.7	1.0	-1.1	1.0	1.1
Bone: minimum diameter	1.9	3.5	4.7	-2.2	-2.0	1.9	-1.9	-1.3
Time in familiar zone, hab. session 1	1.3	1.3	1.7	-1.0	-1.2	1.1	-1.3	-1.0
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.5	0.4	-0.5	0.6	0.1
Total zone transitions, hab. session 1	2.2	3.0	3.4	1.8	1.9	-1.8	1.8	1.4
Total locomotion distance, hab. session 1	0.1	0.2	0.4	-0.0	0.3	-0.5	0.3	0.6
Locomotion velocity, hab. session 1	0.1	0.2	0.5	-0.2	0.2	-0.5	0.3	0.7
Time in familiar zone, hab. session 2	0.3	0.3	0.8	-0.9	-0.4	0.2	-0.4	0.3
Time in novel zone, hab. session 2	0.7	0.7	1.4	1.2	0.9	-0.7	0.9	0.1
Total zone transitions, hab. session 2	0.2	0.3	0.8	0.2	-0.3	0.4	-0.4	-0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.2	-0.3	0.2	-0.3	-0.4
Locomotion velocity, hab. session 2	0.0	0.1	0.1	-0.2	-0.3	0.1	-0.2	-0.3
Novel to familiar place preference ratio	0.6	0.7	1.0	0.6	0.9	-1.0	0.8	0.7
Novelty place preference	0.3	0.3	0.6	0.3	0.6	-0.8	0.5	0.6
Time in novel zone, NPP test	0.4	0.5	0.8	0.4	0.7	-0.9	0.7	0.7
Total zone transitions, NPP test	0.9	1.3	1.6	1.3	1.2	-1.1	1.1	0.8
Total locomotion distance, NPP test	0.1	0.2	0.2	0.3	0.4	-0.4	0.4	0.4
Locomotion velocity, NPP test	0.1	0.2	0.3	0.3	0.4	-0.5	0.4	0.6
Intraocular pressure	0.8	1.1	2.5	-1.6	-1.0	1.0	-0.9	0.3
Delta distance traveled before/after self-admin	0.4	0.4	0.5	-0.6	-0.7	0.7	-0.7	-0.5
Delta ambulatory time before/after self-admin	0.3	0.4	0.4	-0.4	-0.6	0.6	-0.7	-0.7
Parametrial fat weight	0.5	1.0	2.5	-0.0	0.7	-1.0	0.9	1.6
Pavlov. Cond. lever latency	0.8	1.0	2.5	1.6	1.0	-1.0	0.8	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.0	0.1	0.0	0.3	0.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	-0.5	-0.5	0.6	-0.3	-0.5
Pavlov. Cond. index score	0.3	0.3	0.6	-0.8	-0.6	0.7	-0.4	-0.2
Pavlov. Cond. latency score	0.4	0.6	1.0	-1.0	-0.8	0.8	-0.6	-0.4
Pavlov. Cond. lever contacts	1.6	1.8	4.1	-2.0	-1.4	1.3	-1.1	-0.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.3	0.2	-0.3	0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.1	0.9	0.9	-0.8	1.1	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	-0.7	-0.4	0.5	-0.2	0.0
Pavlov. Cond. response bias	0.7	0.8	1.8	-1.3	-0.9	1.0	-0.7	-0.1
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.4	0.5	-0.4	0.5	0.6
Pavlov. Cond. magazine entry latency	1.3	1.5	4.0	2.0	1.2	-0.8	1.1	-0.2
Pavlov. Cond. change in total contacts	0.3	0.4	1.3	0.6	-0.0	0.1	-0.1	-1.2
Pavlov. Cond. index score	0.2	0.2	0.7	0.8	0.3	-0.2	0.3	-0.6
Pavlov. Cond. latency score	0.2	0.3	0.6	0.8	0.2	-0.1	0.2	-0.8
Pavlov. Cond. lever contacts	0.4	0.5	1.4	-0.2	-0.6	0.6	-0.7	-1.2
Pavlov. Cond. magazine entry number	0.6	0.7	1.8	-1.4	-0.8	0.6	-0.7	0.3
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.8	-0.6	-1.0	1.2	-1.1	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	0.8	0.4	-0.3	0.3	-0.4
Pavlov. Cond. response bias	0.1	0.2	0.7	0.4	-0.1	0.1	-0.1	-0.8
Time in closed arm before self-admin	0.2	0.2	0.5	0.7	0.4	0.0	0.4	-0.1
Time in closed arm after self-admin	0.1	0.1	0.2	-0.0	-0.2	0.5	-0.2	-0.3
Time in open arm before self-admin	0.5	0.5	1.2	0.2	0.6	-0.8	0.5	1.1
Time in open arm after self-admin	0.6	0.6	1.2	0.5	0.7	-1.1	0.6	0.9
Bone: periosteal estimation	2.5	5.2	5.8	-2.0	-2.4	2.3	-2.4	-2.3
Bone: periosteal perimeter	4.4	7.4	8.6	-2.9	-2.9	2.7	-2.8	-2.1
Bone: post-yield work	0.8	1.1	2.5	1.6	1.1	-1.0	0.9	-0.1
Progressive ratio test 1 active lever presses	1.9	1.9	4.3	-2.1	-1.4	1.4	-1.2	0.2
Progressive ratio test 1 breakpoint	1.7	1.8	4.0	-2.0	-1.3	1.3	-1.2	0.2
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.8	-0.9	-0.7	0.8	-0.9	-0.2
Progressive ratio test 2 active lever presses	0.7	0.8	1.5	-0.7	-0.9	1.2	-0.8	-0.7
Progressive ratio test 2 breakpoint	0.6	0.7	1.4	-0.6	-0.9	1.2	-0.7	-0.7
Progressive ratio test 2 inactive lever presses	2.1	2.5	4.1	-1.3	-1.6	2.0	-1.5	-1.4
Incentive Sensitization - Responses	0.6	0.6	1.5	-0.1	-0.7	0.9	-0.6	-1.2
Incentive Sensitization - Breakpoint	0.7	0.7	1.6	-0.2	-0.7	0.9	-0.6	-1.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.7	0.4	-0.1	0.1	-0.1	-0.8
Progressive ratio	0.5	0.5	0.9	0.4	0.7	-0.9	0.7	0.9
Food seeking constrained by brief footshock	0.9	1.2	1.6	-0.7	-1.0	1.2	-1.2	-1.2
Seeking ratio, punishment vs. effort	1.4	1.7	3.4	-0.2	-1.1	1.5	-1.2	-1.8
Retroperitoneal fat weight	2.8	9.1	10.7	-3.3	-3.2	3.2	-3.2	-2.0
Reaction time number correct	0.3	0.5	0.7	0.4	0.7	-0.7	0.7	0.8
Reaction time mean minus median	0.3	0.4	0.6	0.4	0.6	-0.4	0.7	0.8
Reaction time mean minus median AUC	0.2	0.2	0.7	0.2	0.4	-0.3	0.4	0.8
Reaction time num false alarms	0.2	0.3	0.8	-0.9	-0.2	0.1	-0.1	0.8
Reaction time num false alarms AUC	0.3	0.4	1.2	-1.1	-0.3	0.1	-0.1	0.9
Reaction time trials correct on left	0.3	0.5	0.7	0.4	0.7	-0.7	0.7	0.8
Reaction time trials on left	0.3	0.5	0.8	0.4	0.7	-0.8	0.7	0.9
Reaction time mean	2.0	2.8	4.8	2.2	1.8	-1.5	1.8	0.8
Reaction time mean AUC	2.4	3.3	5.1	2.3	2.0	-1.7	1.9	1.0
Median of all reaction times	2.5	3.5	6.4	2.5	2.0	-1.7	2.0	0.7
Reaction time omissions	1.4	1.9	2.6	1.6	1.5	-1.3	1.5	0.8
Reaction time false alarm rate	0.4	0.5	1.5	-1.2	-0.7	0.6	-0.5	0.3
Reaction time premature initiation rate	0.6	0.8	2.8	0.5	-0.5	0.7	-0.5	-1.7
Reaction time premature initiations	0.2	0.3	0.9	0.8	0.0	0.1	0.1	-1.0
Std. dev. reaction times	0.8	1.2	1.4	1.1	1.2	-0.9	1.2	1.0
Reaction time trials completed	0.3	0.5	0.8	0.4	0.7	-0.8	0.7	0.9
Reaction time trials AUC	0.1	0.2	0.4	0.2	0.4	-0.5	0.4	0.6
Run reversals in cocaine runway, females	0.6	0.6	1.4	-0.1	0.5	-0.9	0.8	1.2
Run reversals in cocaine runway, males	0.5	0.5	1.6	-1.2	-0.5	0.1	-0.4	0.6
Latency to leave start box in cocaine runway	2.0	2.1	2.5	-1.5	-1.6	1.4	-1.5	-1.3
Latency to leave start box in cocaine runway, F	1.0	1.1	1.2	-1.1	-1.1	1.1	-1.1	-0.8
Latency to leave start box in cocaine runway, M	1.9	1.9	2.3	-1.3	-1.5	1.3	-1.3	-1.4
Std. dev. time between licks in bursts	0.2	0.2	0.7	0.8	0.4	-0.3	0.3	-0.3
Total sessions with >9 infusions	3.7	4.1	7.8	-2.8	-2.1	2.0	-1.9	-0.7
Short access day 1 total inactive lever presses	3.7	4.2	4.8	-2.1	-2.2	2.1	-2.1	-1.7
Short access day 10 total inactive lever presses	0.5	0.6	1.5	-0.2	-0.7	0.6	-0.7	-1.2
Short access day 1 total infusions	2.3	2.4	4.8	-2.2	-1.7	1.4	-1.5	-0.5
Short access day 10 total infusions	5.1	5.7	8.0	-2.8	-2.5	2.6	-2.4	-1.2
Short access total infusions	6.3	7.1	9.4	-3.1	-2.9	2.8	-2.7	-1.7
Short access day 1 locomotion	0.2	0.2	0.4	-0.6	-0.5	0.5	-0.5	-0.3
Short access day 10 total locomotion	0.5	0.6	1.8	-1.3	-0.5	0.2	-0.5	0.8
Short access total locomotion	2.2	2.3	3.2	-1.8	-1.6	1.6	-1.6	-0.9
One hour access (0.3 mA shock)	1.3	1.5	2.3	-1.3	-1.2	1.5	-1.2	-0.6
Compulsive drug intake	1.1	1.1	2.3	1.5	1.1	-1.1	0.9	-0.0
One hour access (shock baseline)	3.3	3.8	5.9	-2.4	-2.0	2.3	-1.8	-0.7
Social response proportion	1.6	1.7	2.0	-1.2	-1.3	1.4	-1.4	-1.2
Social responses	1.4	1.8	3.3	-1.8	-1.4	1.1	-1.4	-0.5
Social time	0.3	0.3	1.3	-0.4	0.3	-0.3	0.4	1.1
Soleus weight	0.3	0.8	1.3	-0.5	-0.9	1.0	-0.9	-1.1
Bone: stiffness	0.8	1.3	3.2	1.8	0.4	-0.0	0.2	-1.7
Tibialis anterior weight	0.1	0.4	0.9	1.0	0.7	-0.7	0.5	0.1
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	0.1	0.4	-0.5	0.2	0.7
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.9	-0.9	-0.7	0.4	-0.5	-0.2
Time to tail flick, test, before self-admin	1.8	1.7	3.4	-1.8	-1.4	1.3	-1.3	-0.4
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.2	-0.1	0.5	-0.0	-0.6
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.2	-0.3	-0.7	0.7	-0.6	-1.1
Delta time to tail flick, test, before/after SA	1.7	1.5	3.2	1.8	1.3	-0.9	1.3	0.1
Tibia length	0.2	0.6	0.8	-0.8	-0.9	0.9	-0.7	-0.7
Ambulatory time before self-admin	0.1	0.1	0.3	-0.6	-0.2	-0.0	-0.1	0.4
Ambulatory time after self-admin	0.2	0.2	0.3	-0.3	-0.5	0.6	-0.4	-0.5
Bone: tissue strength	0.5	0.5	1.5	1.2	0.6	-0.4	0.4	-0.5
Total heroin consumption	0.5	0.6	1.9	0.3	-0.5	0.4	-0.6	-1.4
Bone: trabecular number	0.6	0.9	1.7	0.5	0.9	-0.9	1.0	1.3
Bone: trabecular spacing	2.5	3.3	4.1	-1.6	-1.9	1.6	-2.0	-1.8
Bone: trabecular thickness	0.1	0.1	0.3	0.2	0.4	-0.2	0.5	0.5
Bone: trabecular tissue density	1.3	1.8	3.4	1.8	1.5	-1.3	1.4	0.5
Water consumed over 24 hours	2.2	2.6	2.9	-1.6	-1.7	1.6	-1.7	-1.5
Number of responses in last shaping day	0.0	0.0	0.0	-0.2	-0.0	-0.2	0.0	0.1