Hub : Genes

Tbc1d22a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Tbc1d22a 0.18 0.09 0.0e+00 0.15 0.14 0.14 0.15 1.5e-16 4.6e-15 5.3e-15 4.7e-16
2 NAcc gene expression Tbc1d22a 0.02 0.02 1.2e-03 0.02 0.01 0.02 0.02 2.6e-04 4.7e-03 1.4e-03 1.0e-03
3 Adipose mRNA stability Tbc1d22a 0.04 0.02 1.8e-05 0.04 0.03 0.03 0.03 7.7e-05 9.5e-05 9.4e-05 1.7e-04
4 Adipose gene expression Tbc1d22a 0.09 0.05 2.9e-13 0.1 0.1 0.1 0.1 4.2e-11 6.7e-11 8.3e-11 7.0e-11
5 Adipose alternative polyA XM_039080326.2 0.03 0.03 6.5e-03 0.01 0.01 0.01 0.01 1.4e-02 2.7e-02 5.0e-02 1.8e-02
6 PL mRNA stability Tbc1d22a 0.04 0.03 2.1e-03 0.01 0.02 0.01 0.02 1.6e-02 2.0e-03 7.6e-03 2.2e-03
7 BLA isoform ratio XM_039080323.2 0.05 0.04 6.8e-03 0.01 0 -0 0 1.2e-01 2.1e-01 4.8e-01 3.2e-01
8 RMTg mRNA stability Tbc1d22a 0.14 0.1 7.1e-03 0.02 0.05 -0 0.01 7.6e-02 2.3e-02 4.6e-01 1.5e-01
9 Eye isoform ratio XR_005487292.2 0.65 0.17 6.6e-03 0.1 0.13 0.09 0.14 1.1e-02 5.5e-03 1.6e-02 3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.40.61.00.80.80.8-0.8-0.81.0-0.90.40.6
Area under the delay curve3.54.15.92.22.42.1-2.4-2.02.2-1.81.51.2
BMI with tail2.27.710.2-3.1-3.0-3.03.03.0-2.13.2-3.10.0
BMI without tail0.41.11.6-1.2-1.0-1.11.11.1-1.11.3-1.0-0.5
Body weight1.67.29.4-2.9-2.9-2.72.92.8-2.93.1-1.9-1.7
Weight adjusted by age0.91.32.1-1.5-1.1-1.01.11.0-1.31.3-1.0-0.8
Bone surface0.20.30.50.70.70.7-0.7-0.70.6-0.30.4-0.0
Bone volume0.30.60.90.90.90.9-0.9-0.90.8-0.60.60.2
Breakpoint value in progressive ratio session0.80.92.2-0.8-1.0-0.90.90.90.10.4-1.51.3
Number of licking bursts0.30.51.60.60.60.6-0.6-0.60.0-0.61.3-0.8
Context. condit. distance diff. score1.11.31.7-1.2-1.2-1.31.21.3-1.11.3-1.0-0.5
Locomotion velocity, session 11.11.23.7-0.9-0.9-0.80.90.8-1.70.90.2-1.9
Locomotion distance, session 10.50.61.30.90.80.8-0.8-0.80.1-0.51.2-0.9
Locomotion velocity, session 23.03.56.2-2.0-2.0-1.72.01.7-2.51.8-0.5-2.1
Locomotion distance, session 20.10.20.50.30.30.4-0.3-0.40.6-0.2-0.10.7
Locomotion velocity, session 32.12.48.8-1.1-1.1-1.01.11.0-2.21.10.9-3.0
Locomotion distance, session 30.40.41.90.10.10.2-0.1-0.2-0.6-0.01.3-1.4
Stereotopy head waving bouts, day 30.40.41.4-0.4-0.4-0.40.40.4-0.81.2-0.4-1.0
Stereotopy head waving duration, day 31.21.54.3-0.9-0.9-1.00.91.0-1.32.1-1.0-1.3
Locomotion velocity, session 70.91.03.1-0.7-0.8-0.70.80.7-1.41.30.2-1.8
Locomotion distance, session 70.30.40.7-0.6-0.7-0.60.70.6-0.80.20.2-0.7
Stereotopy head waving bouts, day 71.01.12.5-0.8-0.9-0.90.90.9-1.31.2-0.2-1.6
Stereotopy head waving duration, day 70.30.41.1-0.4-0.4-0.50.40.5-0.80.8-0.1-1.1
Locomotion velocity, session 85.46.47.9-2.8-2.7-2.72.82.7-2.52.7-2.2-1.1
Locomotion distance, session 80.50.81.1-0.9-1.0-1.01.01.0-1.10.7-0.4-0.6
Degree of sensitization distance1.51.52.6-1.3-1.4-1.41.41.4-0.70.8-1.60.6
Degree of sensitization stereotypy0.60.61.0-0.7-0.7-0.80.70.8-1.00.9-0.3-1.0
Conditioned locomotion0.10.10.3-0.3-0.2-0.20.20.2-0.20.5-0.2-0.2
Cocaine response after cond. corrected0.40.40.8-0.7-0.6-0.70.60.7-0.90.20.2-0.8
Cocaine response after cond. not corrected0.30.41.6-0.3-0.3-0.40.30.4-0.8-0.00.7-1.2
Cocaine response before conditioning0.40.40.80.80.70.7-0.7-0.70.4-0.60.9-0.4
Saline control response0.30.40.7-0.8-0.7-0.80.70.8-0.4-0.3-0.50.2
Bone: connectivity density0.20.40.50.60.70.7-0.7-0.70.5-0.50.7-0.2
Bone: cortical apparent density1.52.02.41.51.51.5-1.5-1.51.5-1.40.91.2
Bone: cortical area2.03.14.0-1.9-2.0-2.02.02.0-1.51.7-1.8-0.3
Bone: cortical porosity1.61.82.7-1.6-1.6-1.51.61.5-1.00.6-1.50.5
Bone: cortical porosity1.71.82.7-1.6-1.6-1.51.61.5-1.00.8-1.60.4
Bone: cortical thickness0.20.41.0-0.7-0.6-0.50.60.50.10.2-1.00.9
Bone: cortical thickness2.32.75.7-1.8-1.7-1.71.71.7-0.81.4-2.40.8
Bone: cortical tissue density1.21.61.91.31.31.4-1.3-1.41.4-1.30.81.1
Condit. Reinf. active minus inactive responses0.30.30.90.50.50.5-0.5-0.50.4-0.90.40.5
Condit. Reinf. active-inactive response ratio1.21.31.81.21.31.2-1.3-1.21.2-1.30.80.8
Condit. Reinf. active responses0.80.91.81.01.01.0-1.0-1.00.5-1.21.3-0.1
Condit. Reinf. inactive responses0.30.41.40.40.30.4-0.3-0.4-0.2-0.51.2-0.9
Incentive salience index mean0.10.20.5-0.2-0.2-0.20.20.2-0.7-0.30.5-0.7
Condit. Reinf. lever presses1.21.63.9-1.1-1.1-1.11.11.1-2.00.90.3-2.0
Condit. Reinf. active minus inactive responses0.50.71.2-1.0-0.9-0.90.90.9-0.60.7-1.10.2
Condit. Reinf. active-inactive response ratio0.00.10.1-0.3-0.2-0.10.20.2-0.20.2-0.40.0
Condit. Reinf. active responses1.82.53.3-1.7-1.8-1.71.81.7-1.31.7-1.8-0.1
Condit. Reinf. inactive responses2.83.64.7-1.9-2.1-2.12.12.0-1.72.2-1.9-0.5
Condit. Reinf. lever presses0.71.02.6-0.7-0.9-1.00.91.0-0.91.6-0.9-0.6
Condit. Reinf. lever reinforcers received1.31.82.4-1.4-1.5-1.41.51.4-1.01.3-1.50.0
Conditioned reinforcement - actives0.20.40.6-0.7-0.7-0.80.60.7-0.6-0.4-0.3-0.2
Conditioned reinforcement - inactives0.60.91.7-1.3-1.1-1.31.01.2-0.7-0.0-0.9-0.0
Conditioned locomotion1.62.13.7-1.5-1.4-1.71.41.7-1.90.9-0.4-1.6
Patch foraging indifference point 0 sec0.00.00.10.10.0-0.2-0.00.20.1-0.30.00.1
Patch foraging indifference point AUC0.40.51.11.01.00.6-0.9-0.60.6-0.40.70.3
Delay disc. indifference point, 0s delay0.00.00.2-0.50.0-0.00.00.1-0.00.0-0.20.0
Delay disc. indifference point, 16s delay3.94.35.72.12.42.3-2.4-2.32.3-1.91.51.2
Delay disc. indifference point, 2s delay0.80.81.20.91.11.0-1.1-0.71.1-0.90.40.9
Delay disc. indifference point, 24s delay0.10.21.00.10.3-0.1-0.20.20.4-0.1-0.41.0
Delay disc. indifference point, 4s delay6.56.810.32.93.22.9-3.2-2.72.9-1.81.61.6
Delay disc. indifference point, 8s delay3.23.85.32.22.32.0-2.3-1.92.2-1.61.31.2
Indifference point function ln k2.34.05.5-2.3-2.1-2.12.22.1-2.31.7-1.2-1.7
Indifference point function log k2.34.05.5-2.3-2.1-2.12.22.1-2.31.7-1.2-1.7
Patch foraging total patch changes 0 sec0.10.10.20.40.30.2-0.4-0.20.3-0.50.30.1
Patch foraging total patch changes 12 sec0.00.00.10.30.3-0.1-0.30.00.10.10.1-0.0
Patch foraging total patch changes 18 sec0.40.61.10.90.90.7-0.9-0.70.5-0.91.0-0.1
Patch foraging total patch changes 24 sec0.10.10.40.50.30.1-0.3-0.10.0-0.00.6-0.4
Patch foraging total patch changes 6 sec0.60.91.51.21.20.9-1.1-0.91.1-0.70.70.6
Patch foraging time to switch 0 sec0.20.51.00.60.60.8-0.5-0.81.0-0.3-0.10.9
Patch foraging water rate 0 sec0.20.50.8-0.6-0.6-0.90.50.9-0.80.9-0.7-0.2
Patch foraging water rate 12 sec0.40.91.8-1.1-0.9-1.00.91.0-1.40.20.1-1.2
Patch foraging water rate 18 sec0.10.20.5-0.1-0.1-0.50.10.5-0.70.00.2-0.6
Patch foraging water rate 24 sec0.60.91.4-1.2-1.0-1.11.01.1-0.90.5-0.9-0.1
Patch foraging water rate 6 sec0.20.31.00.10.2-0.1-0.30.0-0.5-0.61.0-0.8
Seeking ratio, delayed vs. immediate footshock1.11.41.91.11.21.3-1.2-1.31.4-1.30.70.9
Distance traveled before self-admin0.20.31.4-0.2-0.2-0.20.10.2-0.8-0.30.7-1.2
Distance traveled after self-admin0.50.71.1-0.9-0.9-1.00.81.0-0.90.4-0.7-0.2
Extensor digitorum longus weight0.41.72.1-1.4-1.4-1.31.41.3-1.41.4-0.8-1.3
Bone: elastic displacement0.40.50.9-0.7-0.8-0.80.80.8-0.90.1-0.1-0.5
Bone: elastic work3.54.65.9-2.4-2.4-2.42.42.4-2.02.0-2.1-0.5
Bone: endosteal estimation2.04.45.5-2.0-2.1-2.32.12.3-2.32.4-1.6-1.6
Bone: endosteal perimeter3.16.68.1-2.7-2.7-2.92.72.9-2.92.6-1.8-1.8
Epididymis fat weight0.82.94.2-2.0-2.0-1.92.02.0-1.01.0-1.80.7
Delta time in closed arm before/after self-admin0.20.20.9-0.3-0.2-0.10.20.10.3-0.1-0.60.9
Delta time in open arm before/after self-admin0.90.94.80.20.30.2-0.3-0.2-0.8-0.11.4-2.2
Diff in mean of infusions in LGA sessions1.82.23.4-1.5-1.7-1.71.71.7-0.80.7-1.81.0
Delay discount exponential model param3.74.15.9-2.2-2.4-2.22.42.0-2.21.9-1.5-1.2
Extinction: sum of active levers before priming0.50.61.5-0.5-0.7-0.80.60.80.10.2-1.21.2
Active lever presses in extinction session 61.61.62.2-1.4-1.4-1.41.41.4-0.91.5-1.30.1
Bone: final force1.22.04.5-1.4-1.4-1.51.41.5-0.51.4-2.10.7
Bone: final moment1.52.45.7-1.5-1.5-1.61.51.6-0.51.6-2.40.9
Food consumed during 24 hour testing period3.64.96.0-2.3-2.3-2.42.32.4-2.42.4-2.0-1.1
Glucose0.10.20.3-0.5-0.4-0.50.40.6-0.2-0.6-0.30.6
Heart weight1.72.66.0-1.7-1.5-1.51.61.5-0.92.5-2.0-0.2
Delay discount hyperbolic model param4.04.46.3-2.3-2.5-2.22.52.1-2.21.9-1.6-1.3
Intermittent access intake day 1-15 change1.22.43.8-1.9-1.9-1.81.91.8-1.60.4-1.4-0.5
Intermittent access intake escalation0.61.11.8-1.3-1.3-1.21.31.1-1.2-0.1-0.7-0.7
Intermittent access intake escalation 20.80.91.3-1.2-1.1-1.01.11.0-0.7-0.6-1.10.3
Intermitt. access day 1 inactive lever presses0.20.61.4-0.7-0.8-0.70.80.60.10.3-1.21.0
Intermitt. access day 15 inactive lever presses1.42.95.0-1.8-1.9-2.21.82.2-1.41.0-1.90.3
Intermitt. access escalation Index0.10.10.30.30.40.3-0.4-0.30.4-0.60.10.2
Intermittent access day 1 total infusions1.93.05.4-2.0-1.8-1.81.81.8-2.31.0-0.2-2.0
Intermittent access day 15 total infusions2.63.86.6-2.4-2.1-2.12.12.1-2.60.4-0.4-2.1
Intermittent access terminal intake (last 3 days)4.76.29.6-3.1-2.8-2.82.82.8-3.00.8-1.1-1.9
Intermittent access total infusions4.04.87.7-2.8-2.4-2.52.42.5-2.60.7-0.8-1.7
Intermittent access day 1 locomotion0.70.92.5-0.9-0.8-0.80.70.8-1.4-0.10.7-1.6
Intermittent access day 15 total locomotion2.44.47.5-2.3-2.3-2.42.32.3-2.71.1-0.5-2.0
Intermittent access total locomotion3.34.06.3-2.3-2.2-2.32.22.3-2.50.8-0.6-1.7
Intermittent access standard deviation1.93.96.0-2.4-2.3-2.42.32.3-1.81.0-1.7-0.4
Left kidney weight11.051.465.1-7.7-7.7-7.67.77.6-7.18.1-6.1-3.7
Right kidney weight11.150.664.7-7.8-7.8-7.67.87.5-6.68.0-6.7-2.7
Cocaine induced anxiety0.60.82.4-0.9-0.8-0.80.80.8-0.10.9-1.51.0
Post-drug Anxiety0.60.63.60.10.0-0.1-0.00.11.0-0.3-1.01.9
Baseline Anxiety0.40.51.30.80.60.5-0.6-0.50.4-1.01.1-0.3
Tail length0.41.54.50.90.90.9-0.9-0.9-0.4-1.52.1-1.6
Length with tail0.41.85.1-1.1-1.2-1.11.21.1-2.00.70.4-2.3
Length without tail1.75.67.7-2.6-2.8-2.62.72.7-2.02.2-2.2-0.3
Times rat made contact with spout0.70.83.0-0.5-0.5-0.50.50.5-1.11.10.3-1.7
Lifetime Intake3.74.56.9-2.6-2.3-2.42.32.4-2.60.7-0.8-1.8
Liver weight, left2.13.45.1-1.9-1.9-1.91.92.0-2.31.7-0.6-2.0
Liver weight, right1.11.96.3-0.9-1.0-1.01.11.1-2.00.90.7-2.5
Locomotor activity2.74.37.3-2.1-1.9-2.11.92.1-2.72.1-0.7-2.4
Locomotor testing distance0.30.51.5-0.6-0.5-0.60.50.6-1.00.50.2-1.2
Locomotor testing rearing0.71.54.6-0.9-1.0-1.11.01.1-1.61.2-0.1-2.1
Locomotion in novel chamber1.72.25.71.51.41.1-1.5-1.1-0.4-0.32.2-2.4
Locomotion in novel chamber post-restriction0.20.30.60.80.60.4-0.7-0.40.60.10.20.5
Fecal boli incidents, locomotor time 10.10.20.3-0.3-0.6-0.50.60.5-0.40.5-0.1-0.4
Change in fecal boli incidents, locomotor task0.20.20.40.60.50.5-0.5-0.5-0.1-0.00.6-0.5
Time >=10cm from walls, locomotor time 10.20.21.90.00.0-0.0-0.0-0.10.11.4-0.50.1
Bouts of movement, locomotor time 10.60.71.1-1.0-0.9-1.00.91.0-0.70.5-0.80.0
Total resting periods, locomotor time 10.40.51.1-0.6-0.7-0.80.70.7-0.20.6-1.00.6
Rest time, locomotor task time 10.60.71.7-0.5-0.8-0.90.80.9-0.91.3-0.3-0.9
Distance moved, locomotor task time 10.00.00.00.20.20.1-0.2-0.10.1-0.1-0.00.2
Vertical activity count, locomotor time 10.10.30.90.50.70.5-0.7-0.50.7-0.2-0.20.9
Time >=10cm from walls, locomotor time 20.40.51.3-0.7-0.6-0.60.60.6-0.10.8-1.10.9
Bouts of movement, locomotor time 20.71.24.00.80.80.7-0.8-0.71.5-1.1-0.22.0
Total resting periods, locomotor time 20.71.13.70.80.80.8-0.8-0.71.5-1.1-0.11.9
Rest time, locomotor task time 22.43.07.01.71.71.9-1.7-1.80.7-1.52.7-1.3
Distance moved, locomotor task time 22.52.93.9-1.9-1.9-2.01.91.8-1.41.6-2.0-0.1
Vertical activity count, locomotor time 22.02.85.1-1.8-1.7-1.91.61.9-1.11.8-2.30.5
Light reinforcement 10.41.03.3-0.4-0.5-0.50.50.6-1.31.60.1-1.8
Light reinforcement 23.35.16.4-2.5-2.5-2.52.52.5-2.42.2-1.6-1.2
Bone: marrow area2.04.35.4-2.0-2.1-2.32.12.3-2.22.3-1.6-1.6
Bone: maximum diameter6.311.814.9-3.7-3.7-3.93.83.9-3.53.4-3.0-1.6
Bone: maximum force1.42.56.2-1.5-1.5-1.61.51.6-0.51.7-2.50.9
Bone: maximum moment1.73.07.6-1.7-1.7-1.81.71.8-0.61.9-2.81.0
Mean time between licks in bursts0.61.62.21.51.51.4-1.5-1.40.8-0.91.4-0.3
Mean num. licks in bursts0.91.52.1-1.3-1.3-1.31.31.3-1.01.2-1.5-0.0
Cd content in liver0.00.10.30.10.10.0-0.1-0.0-0.10.6-0.3-0.2
Co content in liver0.10.10.40.30.30.2-0.3-0.2-0.30.10.4-0.6
Cu content in liver6.98.211.83.13.13.0-3.1-3.03.4-2.81.72.2
Fe content in liver0.50.61.5-0.7-0.7-0.70.70.7-0.10.5-1.21.0
K content in liver0.10.10.3-0.1-0.1-0.10.10.10.1-0.2-0.20.6
Mg content in liver0.20.20.90.10.10.0-0.1-0.10.6-0.3-0.30.9
Mn content in liver1.01.12.1-1.1-1.1-1.21.11.1-1.50.50.1-1.1
Na content in liver2.22.33.41.51.41.8-1.4-1.81.8-1.40.81.4
Rb content in liver0.70.94.30.40.30.3-0.3-0.31.3-0.2-1.12.1
Se content in liver0.00.10.20.10.1-0.1-0.10.1-0.1-0.30.5-0.4
Sr content in liver1.81.62.81.71.71.0-1.7-1.00.4-0.61.6-0.9
Zn content in liver0.30.31.10.60.60.4-0.6-0.40.00.00.6-1.1
Bone: minimum diameter1.83.34.8-1.9-1.9-2.01.92.0-2.21.5-0.9-1.7
Time in familiar zone, hab. session 11.31.32.5-1.1-1.1-1.11.11.1-1.11.6-0.8-1.0
Time in novel zone, hab. session 10.30.30.40.50.50.5-0.5-0.50.5-0.60.00.6
Total zone transitions, hab. session 11.92.63.21.81.71.8-1.7-1.81.8-1.61.11.0
Total locomotion distance, hab. session 10.10.20.50.50.40.5-0.4-0.50.1-0.30.7-0.4
Locomotion velocity, hab. session 10.20.20.70.50.40.5-0.4-0.5-0.1-0.30.8-0.5
Time in familiar zone, hab. session 20.30.31.3-0.3-0.4-0.40.40.4-0.80.20.5-1.1
Time in novel zone, hab. session 20.70.71.30.70.80.8-0.8-0.81.1-0.8-0.11.1
Total zone transitions, hab. session 20.30.31.1-0.4-0.5-0.40.50.50.00.5-1.00.6
Total locomotion distance, hab. session 20.10.10.1-0.2-0.3-0.30.30.3-0.20.1-0.40.1
Locomotion velocity, hab. session 20.00.00.1-0.1-0.3-0.20.30.2-0.20.0-0.30.1
Novel to familiar place preference ratio0.70.71.21.01.11.0-1.1-1.00.6-0.30.7-0.4
Novelty place preference0.50.50.80.80.90.8-0.9-0.80.20.00.6-0.8
Time in novel zone, NPP test0.60.71.00.91.00.9-1.0-0.90.30.00.7-0.8
Total zone transitions, NPP test0.71.11.71.01.01.0-1.0-1.01.3-1.20.60.9
Total locomotion distance, NPP test0.10.20.40.40.30.3-0.3-0.30.4-0.60.40.3
Locomotion velocity, NPP test0.10.20.50.50.30.4-0.3-0.30.4-0.70.60.2
Intraocular pressure0.60.82.1-0.8-0.8-0.70.80.7-1.30.80.5-1.4
Delta distance traveled before/after self-admin0.60.61.1-0.8-0.8-0.80.80.8-0.71.0-0.8-0.4
Delta ambulatory time before/after self-admin0.40.40.8-0.7-0.6-0.70.70.7-0.50.9-0.8-0.2
Parametrial fat weight0.61.33.51.11.31.2-1.2-1.20.5-0.81.9-0.7
Pavlov. Cond. lever latency1.21.53.11.31.31.3-1.3-1.31.7-0.5-0.01.4
Pavlov. Cond. magazine entry latency0.10.10.4-0.2-0.2-0.10.20.1-0.1-0.7-0.10.4
Pavlov. Cond. change in total contacts0.20.30.3-0.6-0.6-0.50.60.5-0.50.0-0.50.4
Pavlov. Cond. index score0.30.30.5-0.7-0.7-0.70.70.7-0.7-0.1-0.2-0.1
Pavlov. Cond. latency score0.40.50.8-0.9-0.9-0.80.90.8-0.90.1-0.3-0.4
Pavlov. Cond. lever contacts1.21.43.0-1.3-1.3-1.31.31.3-1.70.40.1-1.3
Pavlov. Cond. magazine entry number0.10.10.50.20.20.2-0.3-0.20.10.7-0.0-0.4
Pavlov. Cond. intertrial magazine entries0.81.01.81.01.00.9-1.0-0.91.1-1.30.80.9
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.5-0.5-0.50.50.5-0.6-0.30.0-0.1
Pavlov. Cond. response bias0.60.71.2-1.0-1.0-0.91.00.9-1.1-0.1-0.1-0.5
Pavlov. Cond. lever latency0.40.61.00.60.80.8-0.8-0.80.5-1.01.00.1
Pavlov. Cond. magazine entry latency1.11.45.70.70.70.6-0.7-0.61.8-0.6-0.92.4
Pavlov. Cond. change in total contacts0.30.52.0-0.2-0.3-0.40.30.40.40.5-1.41.3
Pavlov. Cond. index score0.20.31.10.1-0.0-0.10.00.10.60.2-0.91.1
Pavlov. Cond. latency score0.30.31.3-0.0-0.1-0.20.10.20.50.4-1.11.2
Pavlov. Cond. lever contacts0.30.51.1-0.6-0.7-0.70.70.7-0.30.7-1.00.3
Pavlov. Cond. magazine entry number0.40.52.0-0.5-0.5-0.30.50.3-1.10.20.6-1.4
Pavlov. Cond. intertrial magazine entries0.81.22.1-1.2-1.3-1.11.31.2-0.50.7-1.40.7
Pavlov. Cond. lever-magazine prob. diff.0.20.21.00.20.10.0-0.1-0.00.60.2-0.71.0
Pavlov. Cond. response bias0.10.10.50.0-0.1-0.10.10.10.40.2-0.70.7
Time in closed arm before self-admin0.71.03.60.70.70.9-0.6-0.90.9-1.90.80.8
Time in closed arm after self-admin0.30.31.00.20.40.6-0.3-0.60.3-1.00.7-0.0
Time in open arm before self-admin0.10.10.20.40.40.4-0.4-0.40.20.50.4-0.3
Time in open arm after self-admin0.10.10.20.20.20.0-0.2-0.0-0.10.40.3-0.4
Bone: periosteal estimation2.75.87.2-2.5-2.6-2.72.62.7-2.42.5-2.1-1.3
Bone: periosteal perimeter4.57.810.5-2.9-2.9-3.12.93.1-3.22.7-1.7-2.1
Bone: post-yield work0.71.12.11.11.21.0-1.1-1.01.40.0-0.31.2
Progressive ratio test 1 active lever presses0.80.92.4-1.1-0.7-0.90.70.9-1.40.10.6-1.5
Progressive ratio test 1 breakpoint0.70.82.3-1.0-0.6-0.80.70.7-1.3-0.00.7-1.5
Progressive ratio test 1 inactive lever presses0.71.11.6-1.2-1.1-1.11.21.0-1.30.8-0.2-1.0
Progressive ratio test 2 active lever presses0.91.12.0-1.4-1.2-1.41.11.3-0.70.2-1.00.6
Progressive ratio test 2 breakpoint0.81.01.8-1.3-1.1-1.31.01.2-0.70.1-0.80.5
Progressive ratio test 2 inactive lever presses0.81.42.5-1.6-1.4-1.51.31.5-0.90.1-0.90.3
Incentive Sensitization - Responses0.91.22.2-1.1-1.1-1.21.01.2-0.20.2-1.51.5
Incentive Sensitization - Breakpoint1.01.32.4-1.2-1.2-1.31.11.3-0.30.3-1.61.4
Sum of active levers in priming session hrs 5-60.10.10.5-0.0-0.1-0.20.00.20.20.1-0.60.7
Progressive ratio0.20.30.80.80.50.4-0.4-0.40.4-0.90.60.1
Food seeking constrained by brief footshock0.91.11.5-1.2-1.1-1.11.11.1-0.61.2-1.20.3
Seeking ratio, punishment vs. effort1.42.04.5-1.6-1.4-1.31.41.3-0.31.6-2.11.2
Retroperitoneal fat weight2.912.217.1-4.1-4.0-3.94.13.8-3.03.3-3.1-0.6
Reaction time number correct0.30.60.90.70.81.0-0.9-0.90.5-0.60.9-0.2
Reaction time mean minus median0.20.40.80.60.50.6-0.5-0.60.4-0.90.90.2
Reaction time mean minus median AUC0.10.20.90.40.40.5-0.4-0.50.2-0.20.9-0.3
Reaction time num false alarms0.40.52.6-0.2-0.2-0.20.20.1-0.9-0.20.9-1.6
Reaction time num false alarms AUC0.40.73.4-0.3-0.3-0.30.30.2-1.1-0.31.0-1.8
Reaction time trials correct on left0.30.60.90.70.81.0-0.9-0.90.5-0.60.9-0.2
Reaction time trials on left0.30.61.00.80.91.0-0.9-1.00.5-0.60.9-0.2
Reaction time mean1.72.75.61.61.51.5-1.5-1.42.1-1.70.52.4
Reaction time mean AUC1.93.14.81.81.71.7-1.7-1.62.2-1.80.72.2
Median of all reaction times2.23.17.41.61.61.5-1.6-1.52.4-1.80.22.7
Reaction time omissions1.11.62.61.31.31.6-1.3-1.61.4-1.00.80.9
Reaction time false alarm rate0.50.82.1-0.7-0.8-0.80.70.8-1.20.00.4-1.4
Reaction time premature initiation rate1.01.44.5-0.9-0.7-0.90.80.80.30.5-2.12.0
Reaction time premature initiations0.30.63.2-0.2-0.0-0.10.10.10.70.1-1.31.8
Std. dev. reaction times0.61.21.91.11.01.1-1.0-1.01.1-1.41.01.0
Reaction time trials completed0.30.61.00.80.91.0-0.9-1.00.5-0.60.9-0.2
Reaction time trials AUC0.20.30.50.50.60.7-0.6-0.70.3-0.40.7-0.2
Run reversals in cocaine runway, females0.90.91.41.11.10.9-1.1-0.90.1-0.61.2-0.9
Run reversals in cocaine runway, males0.90.93.9-0.4-0.4-0.60.40.6-1.50.50.7-2.0
Latency to leave start box in cocaine runway1.51.62.3-1.2-1.3-1.51.21.5-1.41.5-1.1-0.7
Latency to leave start box in cocaine runway, F1.41.62.1-1.3-1.4-1.41.31.4-1.31.5-1.1-0.7
Latency to leave start box in cocaine runway, M0.30.30.6-0.4-0.3-0.80.30.8-0.70.5-0.4-0.3
Std. dev. time between licks in bursts0.20.21.00.30.30.3-0.3-0.30.7-0.1-0.51.0
Total sessions with >9 infusions2.42.94.7-1.8-1.7-1.81.61.7-2.21.5-0.8-1.9
Short access day 1 total inactive lever presses3.95.17.0-2.6-2.6-2.62.62.5-2.21.9-1.9-0.8
Short access day 10 total inactive lever presses0.41.11.9-1.1-1.3-1.11.41.1-0.70.8-1.00.1
Short access day 1 total infusions1.31.73.1-1.5-1.2-1.41.21.3-1.80.8-0.4-1.7
Short access day 10 total infusions2.83.65.6-2.3-2.1-2.12.12.1-2.41.0-0.7-1.6
Short access total infusions3.44.36.2-2.5-2.3-2.42.32.3-2.41.3-1.2-1.5
Short access day 1 locomotion0.10.20.3-0.5-0.4-0.50.40.5-0.60.0-0.2-0.3
Short access day 10 total locomotion0.61.15.30.20.1-0.0-0.1-0.0-1.30.11.6-2.3
Short access total locomotion0.70.91.8-1.0-0.9-0.90.90.9-1.40.40.1-1.3
One hour access (0.3 mA shock)2.22.64.4-2.1-1.9-1.81.91.8-1.60.8-1.0-0.8
Compulsive drug intake0.20.20.80.30.10.2-0.1-0.20.60.2-0.60.9
One hour access (shock baseline)2.13.25.1-2.3-2.0-2.02.02.0-2.10.6-0.6-1.4
Social response proportion1.61.82.3-1.5-1.5-1.41.41.4-1.31.5-1.2-0.8
Social responses1.41.83.7-1.1-1.3-1.11.21.1-1.81.6-0.2-1.9
Social time0.30.41.50.20.20.3-0.2-0.3-0.4-0.71.2-1.1
Soleus weight0.41.21.9-1.2-1.3-1.21.31.2-0.70.9-1.40.4
Bone: stiffness0.71.25.3-0.0-0.0-0.10.00.11.30.5-1.92.3
Tibialis anterior weight0.10.50.90.90.80.8-0.8-0.91.0-0.20.10.3
Time to tail flick, vehicle, before self-admin0.20.20.30.50.40.5-0.4-0.50.2-0.00.6-0.4
Time to tail flick, vehicle, after self-admin0.10.10.3-0.1-0.2-0.30.30.3-0.5-0.30.2-0.5
Time to tail flick, test, before self-admin1.41.42.8-1.1-1.2-1.11.21.1-1.61.2-0.2-1.7
Time to tail flick, test, after self-admin0.40.40.9-0.5-0.7-0.70.70.7-0.2-0.0-0.90.9
Delta time to tail flick, vehicle, before/after SA0.80.81.3-0.9-0.9-1.00.81.0-0.60.9-1.10.2
Delta time to tail flick, test, before/after SA1.41.44.80.90.90.8-0.8-0.81.5-1.5-0.12.2
Tibia length0.30.71.3-1.0-1.0-1.01.01.1-0.90.2-0.6-0.1
Ambulatory time before self-admin0.30.52.4-0.0-0.0-0.0-0.10.0-0.8-0.41.1-1.6
Ambulatory time after self-admin0.10.10.2-0.3-0.2-0.20.10.2-0.3-0.40.0-0.3
Bone: tissue strength0.40.42.00.20.10.3-0.1-0.31.0-0.3-0.61.4
Total heroin consumption1.61.83.9-0.9-1.3-1.51.21.5-0.11.2-2.01.7
Bone: trabecular number0.61.01.40.91.01.1-1.0-1.10.7-1.21.2-0.2
Bone: trabecular spacing2.33.16.4-1.7-1.7-1.81.71.8-1.72.5-1.6-1.0
Bone: trabecular thickness0.10.20.90.20.30.1-0.3-0.10.2-1.00.40.4
Bone: trabecular tissue density1.21.72.61.41.31.4-1.3-1.41.6-1.30.61.4
Water consumed over 24 hours1.01.31.7-1.1-1.1-1.21.11.2-1.31.3-0.9-0.8
Number of responses in last shaping day0.30.30.50.60.70.6-0.7-0.70.5-0.20.30.1