Hub : Genes

Tbc1d16

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Tbc1d16 0.11 0.06 5.2e-09 0.03 0.07 0.07 0.07 1.4e-04 6.7e-08 2.2e-08 2.4e-08
2 PL gene expression Tbc1d16 0.14 0.08 5.2e-13 0.1 0.11 0.11 0.11 2.3e-11 3.9e-12 6.1e-12 7.5e-12
3 Brain gene expression Tbc1d16 0.11 0.06 1.5e-10 0.1 0.1 0.09 0.1 5.6e-10 4.9e-10 6.3e-09 3.1e-09
4 Adipose gene expression Tbc1d16 0.06 0.03 2.4e-07 0.06 0.06 0.05 0.06 4.9e-07 1.2e-07 2.4e-06 4.9e-07
5 NAcc gene expression Tbc1d16 0.08 0.04 2.4e-13 0.07 0.08 0.08 0.07 3.6e-11 1.4e-12 1.2e-11 5.6e-11
6 NAcc mRNA stability Tbc1d16 0.08 0.04 2.6e-13 0.09 0.09 0.09 0.09 1.0e-13 3.6e-13 1.7e-13 1.2e-13
7 BLA gene expression Tbc1d16 0.09 0.05 1.0e-04 0.06 0.04 0.03 0.05 6.7e-04 2.5e-03 8.7e-03 1.6e-03
8 IC gene expression Tbc1d16 0.14 0.08 5.3e-05 0.1 0.07 0.07 0.09 7.9e-05 7.4e-04 7.7e-04 1.8e-04
9 pVTA gene expression Tbc1d16 0.07 0.06 4.0e-04 0.06 0.04 0.05 0.04 3.1e-05 7.2e-04 8.4e-05 2.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.71.32.0-1.3-1.3-1.2-0.9-0.81.4-1.0-1.3-0.8
Area under the delay curve2.63.15.42.31.91.70.71.1-2.32.02.01.0
BMI with tail0.20.62.3-1.2-0.4-0.60.5-1.50.2-0.2-0.6-0.5
BMI without tail0.51.44.2-1.9-0.7-1.01.2-2.01.1-0.6-0.8-0.4
Body weight0.62.711.2-0.31.61.23.3-0.7-1.51.61.01.7
Weight adjusted by age0.50.83.2-0.40.60.41.8-0.4-0.60.90.41.3
Bone surface0.20.30.70.10.60.80.60.8-0.50.1-0.00.6
Bone volume0.20.30.9-0.9-0.3-0.2-0.1-0.00.5-0.8-0.9-0.2
Breakpoint value in progressive ratio session0.40.51.2-1.1-0.6-0.70.0-1.00.9-0.3-0.6-0.2
Number of licking bursts0.10.10.20.20.40.30.5-0.0-0.50.40.40.4
Context. condit. distance diff. score0.40.52.3-0.9-0.3-0.60.2-1.50.0-0.6-0.2-0.8
Locomotion velocity, session 12.42.66.32.21.71.90.12.5-1.41.31.30.9
Locomotion distance, session 11.01.23.1-0.3-1.2-1.1-1.8-0.51.4-0.7-0.8-1.3
Locomotion velocity, session 20.70.83.20.8-0.5-0.1-1.81.30.9-0.4-0.4-0.6
Locomotion distance, session 22.33.25.0-1.6-2.2-2.1-1.9-1.32.2-1.3-1.8-1.4
Locomotion velocity, session 30.60.72.01.10.81.0-0.21.4-0.60.60.70.4
Locomotion distance, session 30.30.41.90.5-0.3-0.1-1.40.50.5-0.0-0.1-0.6
Stereotopy head waving bouts, day 30.30.30.90.50.80.90.20.9-0.60.10.10.2
Stereotopy head waving duration, day 30.20.20.60.00.70.70.20.6-0.4-0.3-0.2-0.1
Locomotion velocity, session 70.10.20.30.60.30.3-0.40.3-0.3-0.10.6-0.5
Locomotion distance, session 72.93.76.6-1.4-1.7-1.7-2.4-1.31.8-2.2-1.8-2.6
Stereotopy head waving bouts, day 70.70.71.60.41.21.01.30.1-1.10.70.70.7
Stereotopy head waving duration, day 71.31.62.90.71.61.51.70.6-1.51.11.11.2
Locomotion velocity, session 80.20.30.50.30.70.50.2-0.4-0.6-0.10.7-0.7
Locomotion distance, session 83.45.08.0-2.6-2.2-2.4-1.4-2.82.1-2.0-2.0-2.2
Degree of sensitization distance2.32.33.9-2.0-1.4-1.5-0.6-1.81.2-1.8-1.5-1.4
Degree of sensitization stereotypy0.20.20.8-0.20.50.30.9-0.5-0.40.40.10.3
Conditioned locomotion0.91.04.0-1.5-0.8-1.10.7-2.00.2-0.3-0.5-0.1
Cocaine response after cond. corrected0.00.00.10.10.20.3-0.00.2-0.30.0-0.1-0.0
Cocaine response after cond. not corrected0.20.20.60.50.50.6-0.20.8-0.40.10.20.0
Cocaine response before conditioning0.20.30.70.80.50.6-0.20.8-0.20.20.6-0.0
Saline control response0.40.62.4-0.10.70.61.6-0.2-0.70.70.60.9
Bone: connectivity density0.30.50.9-0.5-0.8-0.8-0.8-0.50.9-0.4-0.5-0.6
Bone: cortical apparent density1.21.64.7-0.3-1.4-1.2-2.2-0.21.7-0.9-1.0-1.3
Bone: cortical area2.84.39.21.31.71.43.00.2-2.12.42.42.6
Bone: cortical porosity1.31.52.30.81.41.51.31.5-1.20.80.71.3
Bone: cortical porosity1.82.02.81.01.61.61.71.3-1.51.11.21.4
Bone: cortical thickness1.72.96.21.00.90.62.4-0.1-1.32.42.12.5
Bone: cortical thickness0.81.02.40.80.40.11.1-0.4-0.61.61.51.2
Bone: cortical tissue density1.31.85.1-0.3-1.5-1.3-2.3-0.11.7-1.0-1.1-1.4
Condit. Reinf. active minus inactive responses0.30.41.4-0.4-0.5-0.70.6-1.20.20.40.30.4
Condit. Reinf. active-inactive response ratio0.30.41.6-0.5-0.7-0.90.2-1.30.4-0.00.1-0.1
Condit. Reinf. active responses0.50.61.9-0.6-0.7-0.90.9-1.40.30.50.20.6
Condit. Reinf. inactive responses0.10.20.3-0.5-0.5-0.50.3-0.60.40.1-0.30.3
Incentive salience index mean0.30.30.9-0.2-0.4-0.60.7-1.00.10.70.50.6
Condit. Reinf. lever presses0.20.30.6-0.5-0.7-0.7-0.2-0.80.6-0.2-0.3-0.3
Condit. Reinf. active minus inactive responses0.70.91.90.70.80.61.2-0.3-1.01.31.40.8
Condit. Reinf. active-inactive response ratio1.01.22.70.60.90.81.60.1-1.01.41.21.3
Condit. Reinf. active responses0.20.31.4-0.4-0.4-0.6-0.0-1.20.30.00.1-0.5
Condit. Reinf. inactive responses1.41.82.4-1.1-1.4-1.4-1.5-1.21.3-1.3-1.2-1.6
Condit. Reinf. lever presses2.12.94.9-2.0-1.6-1.8-0.9-2.21.6-1.6-1.6-1.6
Condit. Reinf. lever reinforcers received0.71.03.2-1.0-1.0-1.2-0.4-1.80.8-0.5-0.4-1.0
Conditioned reinforcement - actives0.71.32.5-1.4-1.3-1.1-0.9-0.60.6-1.3-1.6-0.9
Conditioned reinforcement - inactives0.10.10.4-0.40.0-0.00.6-0.40.3-0.4-0.0-0.3
Conditioned locomotion0.91.12.0-1.3-1.4-1.3-0.5-1.10.2-1.3-1.0-0.7
Patch foraging indifference point 0 sec2.03.75.9-2.3-2.1-2.1-1.1-1.82.4-1.7-2.1-1.4
Patch foraging indifference point AUC0.00.10.3-0.2-0.2-0.30.0-0.50.0-0.1-0.1-0.1
Delay disc. indifference point, 0s delay1.92.14.01.31.61.41.30.6-2.01.41.81.1
Delay disc. indifference point, 16s delay0.20.20.60.3-0.2-0.4-0.7-0.6-0.00.20.2-0.8
Delay disc. indifference point, 2s delay2.42.64.41.81.81.61.11.0-1.82.11.81.4
Delay disc. indifference point, 24s delay0.91.03.01.70.60.7-0.91.4-0.81.10.50.4
Delay disc. indifference point, 4s delay3.03.25.41.82.11.81.40.9-2.32.01.91.2
Delay disc. indifference point, 8s delay5.86.810.13.02.92.81.52.2-3.22.72.71.9
Indifference point function ln k1.01.72.6-1.2-1.3-1.1-1.6-0.41.3-1.6-1.5-1.4
Indifference point function log k1.01.72.6-1.2-1.3-1.1-1.6-0.41.3-1.6-1.5-1.4
Patch foraging total patch changes 0 sec2.65.07.1-2.7-2.4-2.4-1.3-2.22.6-2.1-2.4-1.7
Patch foraging total patch changes 12 sec1.62.14.7-1.6-1.6-1.6-0.8-1.22.2-0.9-1.7-0.8
Patch foraging total patch changes 18 sec2.13.24.9-2.0-1.9-2.1-1.2-2.21.9-1.2-1.8-1.5
Patch foraging total patch changes 24 sec0.20.31.3-0.8-0.3-0.50.7-1.10.20.2-0.30.3
Patch foraging total patch changes 6 sec1.01.54.3-1.4-1.4-1.3-0.4-0.92.1-0.5-1.5-0.1
Patch foraging time to switch 0 sec0.40.71.91.40.80.9-0.11.1-0.41.10.80.4
Patch foraging water rate 0 sec1.12.46.3-2.5-1.2-1.50.5-2.50.6-1.4-1.2-0.7
Patch foraging water rate 12 sec1.83.85.9-2.2-2.1-2.2-1.2-2.41.0-2.3-1.3-2.1
Patch foraging water rate 18 sec2.53.99.5-3.1-1.6-1.7-0.3-2.21.4-2.3-2.3-1.6
Patch foraging water rate 24 sec6.28.717.6-4.2-2.7-3.0-0.7-3.92.2-3.1-2.9-2.5
Patch foraging water rate 6 sec0.60.91.8-1.3-0.9-1.0-0.3-1.30.7-1.0-0.7-1.0
Seeking ratio, delayed vs. immediate footshock0.60.82.20.10.80.71.20.4-0.11.40.31.5
Distance traveled before self-admin0.40.52.0-0.10.90.71.4-0.1-0.10.70.70.7
Distance traveled after self-admin2.02.54.3-2.1-1.6-1.7-0.5-2.01.5-1.5-1.4-1.4
Extensor digitorum longus weight1.24.77.2-2.1-2.4-2.6-1.6-2.72.4-1.7-1.9-1.8
Bone: elastic displacement0.50.61.3-1.1-1.1-1.10.1-1.10.8-0.2-0.50.2
Bone: elastic work0.91.24.1-0.00.40.22.0-0.2-0.71.31.01.9
Bone: endosteal estimation0.00.10.3-0.20.10.1-0.0-0.3-0.0-0.5-0.3-0.5
Bone: endosteal perimeter1.63.44.71.62.12.02.11.3-2.21.51.81.7
Epididymis fat weight0.20.73.1-1.0-0.3-0.61.0-1.8-0.4-0.30.0-0.2
Delta time in closed arm before/after self-admin0.30.30.90.80.20.10.2-0.1-0.60.51.00.2
Delta time in open arm before/after self-admin0.90.82.4-1.2-0.8-0.8-0.3-0.81.6-0.8-0.9-0.5
Diff in mean of infusions in LGA sessions0.10.20.50.20.40.30.60.00.20.70.20.5
Delay discount exponential model param3.23.56.2-2.5-2.1-1.9-0.7-1.42.4-2.2-2.0-1.1
Extinction: sum of active levers before priming0.60.71.2-0.4-1.0-0.9-1.1-0.50.6-0.9-0.6-1.1
Active lever presses in extinction session 60.10.10.6-0.10.10.00.10.00.70.30.10.3
Bone: final force1.62.57.80.41.41.02.8-0.3-1.41.81.52.0
Bone: final moment1.52.48.30.11.30.92.9-0.4-1.41.71.42.0
Food consumed during 24 hour testing period0.20.20.9-0.60.0-0.20.7-1.0-0.5-0.10.0-0.1
Glucose1.32.08.62.10.81.3-1.32.9-0.80.50.60.5
Heart weight0.40.61.50.80.50.41.00.1-0.90.91.20.7
Delay discount hyperbolic model param3.33.76.1-2.5-2.1-1.9-0.8-1.42.4-2.2-2.1-1.2
Intermittent access intake day 1-15 change0.20.52.10.70.40.40.40.3-1.50.30.80.5
Intermittent access intake escalation0.20.42.00.60.30.30.30.2-1.40.10.70.4
Intermittent access intake escalation 20.70.82.90.70.80.80.80.6-1.70.60.90.9
Intermitt. access day 1 inactive lever presses0.41.43.9-1.9-0.8-1.10.7-2.00.6-0.9-1.0-0.6
Intermitt. access day 15 inactive lever presses0.40.82.6-1.2-0.8-1.00.2-1.60.9-0.4-0.5-0.7
Intermitt. access escalation Index0.20.30.6-0.4-0.2-0.40.4-0.70.80.40.00.8
Intermittent access day 1 total infusions0.71.11.5-1.2-1.2-1.1-0.7-0.71.2-0.9-1.2-0.9
Intermittent access day 15 total infusions0.10.20.5-0.5-0.7-0.6-0.1-0.5-0.1-0.4-0.3-0.2
Intermittent access terminal intake (last 3 days)0.00.10.2-0.2-0.3-0.30.2-0.2-0.4-0.10.00.1
Intermittent access total infusions0.20.20.5-0.6-0.7-0.7-0.2-0.50.2-0.3-0.6-0.3
Intermittent access day 1 locomotion0.40.60.9-0.9-0.9-0.9-0.5-0.60.7-0.8-0.9-0.5
Intermittent access day 15 total locomotion0.10.20.8-0.1-0.2-0.20.4-0.3-0.9-0.40.3-0.0
Intermittent access total locomotion0.20.30.6-0.6-0.6-0.6-0.1-0.6-0.3-0.8-0.4-0.4
Intermittent access standard deviation1.53.25.72.21.81.71.11.1-2.41.72.31.0
Left kidney weight0.83.55.51.72.32.31.91.5-1.91.61.81.5
Right kidney weight0.52.33.31.61.61.51.41.0-1.41.81.71.4
Cocaine induced anxiety1.62.24.00.91.61.52.00.9-1.31.61.22.0
Post-drug Anxiety0.40.50.80.70.90.80.70.5-0.90.40.60.6
Baseline Anxiety1.01.22.8-0.3-1.0-0.8-1.7-0.10.6-1.4-1.0-1.6
Tail length0.83.112.50.21.61.23.5-0.3-1.11.61.62.1
Length with tail2.310.019.52.13.53.24.41.6-2.93.33.03.5
Length without tail2.27.210.82.32.92.82.81.8-2.73.32.32.9
Times rat made contact with spout0.20.20.6-0.8-0.4-0.30.5-0.30.2-0.1-0.40.4
Lifetime Intake0.20.20.5-0.5-0.7-0.6-0.4-0.40.2-0.3-0.5-0.5
Liver weight, left0.50.82.50.81.11.30.31.6-0.50.30.30.6
Liver weight, right1.11.86.10.21.31.02.5-0.0-0.71.71.01.8
Locomotor activity0.20.41.3-0.5-0.2-0.1-0.70.20.4-1.1-0.6-0.9
Locomotor testing distance0.40.71.9-0.9-0.5-0.4-0.9-0.30.5-1.4-1.0-1.2
Locomotor testing rearing0.91.72.5-1.6-1.2-1.3-0.8-1.61.1-1.5-1.1-1.5
Locomotion in novel chamber0.20.30.5-0.7-0.4-0.4-0.1-0.60.6-0.7-0.7-0.5
Locomotion in novel chamber post-restriction0.10.20.6-0.6-0.10.00.60.0-0.0-0.7-0.40.1
Fecal boli incidents, locomotor time 10.40.51.2-0.4-1.1-0.9-1.1-0.20.9-0.3-0.6-0.4
Change in fecal boli incidents, locomotor task0.40.41.20.1-0.10.1-1.10.90.5-0.6-0.8-0.3
Time >=10cm from walls, locomotor time 10.30.30.9-0.6-0.3-0.5-0.2-1.00.0-0.3-0.2-0.9
Bouts of movement, locomotor time 10.40.41.90.3-0.7-0.5-1.40.30.5-0.4-0.4-0.7
Total resting periods, locomotor time 10.60.72.60.2-0.8-0.6-1.60.50.7-0.7-0.7-0.8
Rest time, locomotor task time 10.20.21.30.30.10.4-0.41.20.20.0-0.40.1
Distance moved, locomotor task time 10.10.20.70.00.40.10.8-0.5-0.20.50.50.3
Vertical activity count, locomotor time 10.10.31.4-0.5-0.4-0.60.3-1.2-0.2-0.20.3-0.3
Time >=10cm from walls, locomotor time 20.00.00.1-0.2-0.0-0.00.10.00.00.3-0.30.3
Bouts of movement, locomotor time 20.10.20.80.8-0.2-0.1-0.90.3-0.2-0.20.5-0.4
Total resting periods, locomotor time 20.10.20.50.7-0.2-0.2-0.70.1-0.3-0.30.5-0.3
Rest time, locomotor task time 20.10.10.30.50.10.2-0.10.5-0.5-0.10.2-0.1
Distance moved, locomotor task time 20.40.51.10.40.70.60.90.1-0.51.00.61.0
Vertical activity count, locomotor time 20.10.10.30.10.0-0.10.3-0.6-0.10.50.60.1
Light reinforcement 11.12.75.8-2.1-2.0-2.1-0.4-2.41.5-1.2-1.2-1.1
Light reinforcement 20.20.41.4-0.20.1-0.11.2-0.7-0.60.50.60.6
Bone: marrow area0.00.10.2-0.20.20.1-0.0-0.3-0.0-0.5-0.3-0.5
Bone: maximum diameter3.66.89.22.32.82.63.01.4-3.02.52.92.5
Bone: maximum force1.01.86.70.01.10.82.6-0.4-1.11.51.11.8
Bone: maximum moment1.01.76.8-0.21.00.72.6-0.5-1.01.30.91.8
Mean time between licks in bursts0.10.10.40.40.20.3-0.60.6-0.5-0.20.1-0.2
Mean num. licks in bursts0.50.71.1-1.0-1.1-1.0-0.5-0.61.0-0.7-1.0-0.5
Cd content in liver3.43.84.7-1.9-2.1-2.2-1.7-2.12.1-1.6-1.9-1.9
Co content in liver0.20.20.4-0.5-0.7-0.6-0.3-0.20.6-0.2-0.30.0
Cu content in liver0.20.30.70.20.50.50.80.4-0.60.40.50.7
Fe content in liver0.40.51.1-1.0-0.3-0.3-0.4-0.60.4-1.1-0.9-1.0
K content in liver0.30.21.1-0.5-0.5-0.70.4-1.00.1-0.10.00.1
Mg content in liver1.81.82.7-1.4-1.6-1.7-0.9-1.61.3-1.2-1.1-1.1
Mn content in liver0.40.40.90.40.70.60.70.3-1.00.60.70.5
Na content in liver0.00.00.0-0.00.00.00.1-0.1-0.2-0.00.2-0.0
Rb content in liver1.11.24.3-1.5-1.0-1.30.2-2.10.7-0.6-0.7-0.6
Se content in liver0.40.41.1-0.9-0.6-0.7-0.1-1.00.3-0.6-0.6-0.6
Sr content in liver0.10.10.50.2-0.2-0.0-0.40.70.1-0.1-0.20.2
Zn content in liver0.10.10.4-0.2-0.1-0.10.6-0.2-0.20.10.10.6
Bone: minimum diameter1.01.86.10.21.31.02.5-0.1-1.31.11.01.7
Time in familiar zone, hab. session 10.90.81.3-1.0-0.9-0.9-0.8-0.60.9-1.1-1.1-0.8
Time in novel zone, hab. session 10.90.91.30.91.21.10.90.5-1.11.01.10.6
Total zone transitions, hab. session 11.21.62.2-1.2-1.3-1.3-1.2-1.11.4-1.1-1.5-1.2
Total locomotion distance, hab. session 11.21.73.3-1.6-1.3-1.5-0.5-1.81.3-0.9-1.2-1.0
Locomotion velocity, hab. session 11.41.93.2-1.7-1.5-1.6-0.6-1.81.4-1.0-1.4-1.0
Time in familiar zone, hab. session 20.70.71.3-1.0-0.6-0.6-0.8-0.60.5-1.1-1.1-1.1
Time in novel zone, hab. session 20.30.30.50.70.50.50.30.5-0.30.70.70.6
Total zone transitions, hab. session 24.55.87.1-2.6-2.6-2.6-2.0-2.22.6-2.1-2.7-2.1
Total locomotion distance, hab. session 23.85.07.2-2.6-2.6-2.7-1.4-2.52.5-1.6-2.2-1.6
Locomotion velocity, hab. session 23.14.26.4-2.4-2.4-2.5-1.1-2.42.2-1.3-2.0-1.3
Novel to familiar place preference ratio1.61.83.3-1.6-1.7-1.8-0.3-1.71.6-0.5-1.2-0.1
Novelty place preference1.31.42.5-1.5-1.5-1.6-0.2-1.51.4-0.4-1.1-0.0
Time in novel zone, NPP test1.81.93.3-1.7-1.7-1.8-0.5-1.61.6-0.7-1.4-0.3
Total zone transitions, NPP test2.33.34.1-1.8-2.0-2.0-1.6-1.82.0-1.5-1.7-1.8
Total locomotion distance, NPP test5.77.810.4-3.2-3.2-3.2-2.0-2.93.1-2.3-2.8-2.2
Locomotion velocity, NPP test4.46.38.6-2.9-2.9-2.9-1.7-2.72.8-2.0-2.4-1.9
Intraocular pressure0.91.32.9-1.0-1.4-1.6-0.6-1.71.2-0.6-0.8-0.8
Delta distance traveled before/after self-admin2.22.43.7-1.3-1.9-1.9-1.5-1.51.0-1.6-1.3-1.7
Delta ambulatory time before/after self-admin2.32.84.1-1.2-2.0-1.9-2.0-1.31.2-1.7-1.6-1.9
Parametrial fat weight0.40.92.6-1.3-0.8-0.80.1-1.00.3-1.6-0.9-0.8
Pavlov. Cond. lever latency1.72.24.7-1.4-1.1-1.2-1.4-1.61.1-1.7-1.2-2.2
Pavlov. Cond. magazine entry latency2.83.65.81.42.01.92.41.1-2.01.91.82.1
Pavlov. Cond. change in total contacts0.10.10.40.0-0.5-0.4-0.10.00.60.2-0.20.4
Pavlov. Cond. index score2.12.75.31.01.51.42.30.9-1.51.81.42.2
Pavlov. Cond. latency score2.63.35.81.31.71.72.31.4-1.71.91.62.4
Pavlov. Cond. lever contacts0.40.51.80.40.30.40.80.7-0.20.80.31.3
Pavlov. Cond. magazine entry number2.73.45.1-1.4-1.9-1.9-2.3-1.41.8-1.8-1.6-2.2
Pavlov. Cond. intertrial magazine entries1.61.93.2-1.3-1.8-1.8-1.1-1.51.6-1.0-1.2-1.0
Pavlov. Cond. lever-magazine prob. diff.1.51.94.30.81.21.12.10.6-1.31.61.22.0
Pavlov. Cond. response bias1.92.34.01.31.41.41.81.2-1.41.61.42.0
Pavlov. Cond. lever latency2.02.75.52.21.61.80.42.3-1.41.31.71.2
Pavlov. Cond. magazine entry latency3.23.95.0-1.8-1.9-1.9-2.0-1.81.9-2.1-2.1-2.2
Pavlov. Cond. change in total contacts2.54.05.2-2.0-2.2-2.3-1.7-2.22.0-1.7-2.0-1.8
Pavlov. Cond. index score2.83.75.2-2.2-2.0-2.1-1.4-2.31.8-1.8-2.0-1.8
Pavlov. Cond. latency score2.33.14.8-1.9-1.8-1.9-1.2-2.21.6-1.6-1.8-1.7
Pavlov. Cond. lever contacts2.53.46.1-2.4-1.8-2.0-0.7-2.51.7-1.5-2.0-1.5
Pavlov. Cond. magazine entry number2.83.54.01.71.92.01.81.9-1.81.71.92.0
Pavlov. Cond. intertrial magazine entries0.40.62.00.20.70.51.4-0.3-0.80.71.10.8
Pavlov. Cond. lever-magazine prob. diff.2.83.74.6-2.1-1.9-2.1-1.5-2.11.8-1.8-2.0-1.9
Pavlov. Cond. response bias3.34.55.9-2.4-2.2-2.3-1.4-2.42.0-1.9-2.3-1.9
Time in closed arm before self-admin0.30.41.10.90.50.6-0.11.0-0.50.20.30.4
Time in closed arm after self-admin0.80.92.91.70.50.6-0.41.0-1.40.01.00.3
Time in open arm before self-admin0.20.20.80.00.30.30.40.2-0.50.90.30.4
Time in open arm after self-admin1.11.23.3-1.6-0.8-0.8-0.4-0.81.8-0.7-1.3-0.9
Bone: periosteal estimation0.81.84.10.81.31.12.00.1-1.51.41.41.5
Bone: periosteal perimeter5.59.512.62.63.23.03.52.2-3.33.13.13.5
Bone: post-yield work0.30.51.1-0.4-0.9-0.9-0.7-0.61.0-0.2-0.5-0.4
Progressive ratio test 1 active lever presses0.50.61.1-0.7-1.0-1.0-0.5-0.80.6-0.6-0.6-0.7
Progressive ratio test 1 breakpoint0.40.51.0-0.7-1.0-0.9-0.5-0.70.6-0.6-0.5-0.6
Progressive ratio test 1 inactive lever presses0.60.93.8-1.4-0.7-1.00.9-2.00.5-0.2-0.3-0.4
Progressive ratio test 2 active lever presses0.70.81.2-1.0-1.0-1.0-0.6-0.80.5-1.1-0.9-1.1
Progressive ratio test 2 breakpoint0.60.71.1-0.9-1.0-1.0-0.5-0.80.4-1.0-0.8-1.0
Progressive ratio test 2 inactive lever presses0.00.10.2-0.10.0-0.10.5-0.30.3-0.20.3-0.2
Incentive Sensitization - Responses0.00.10.2-0.2-0.1-0.10.0-0.1-0.3-0.4-0.1-0.5
Incentive Sensitization - Breakpoint0.00.10.2-0.2-0.1-0.10.0-0.1-0.4-0.4-0.0-0.5
Sum of active levers in priming session hrs 5-60.80.71.2-0.9-1.0-1.0-0.5-1.01.1-0.2-0.7-0.8
Progressive ratio0.50.71.7-0.6-0.9-0.8-1.2-0.11.2-0.3-1.3-0.4
Food seeking constrained by brief footshock0.20.20.90.50.50.50.20.4-0.31.00.30.2
Seeking ratio, punishment vs. effort0.40.61.60.80.80.60.8-0.0-1.10.51.30.1
Retroperitoneal fat weight0.62.49.8-1.8-0.3-0.92.3-3.1-1.1-0.70.3-0.0
Reaction time number correct3.67.011.2-3.1-2.5-2.7-1.4-3.32.2-2.7-2.5-2.9
Reaction time mean minus median0.20.61.40.90.70.80.21.2-0.80.50.60.7
Reaction time mean minus median AUC0.51.31.51.21.21.21.11.0-1.21.21.11.2
Reaction time num false alarms0.20.30.5-0.3-0.3-0.2-0.60.10.6-0.7-0.7-0.5
Reaction time num false alarms AUC0.30.40.9-0.5-0.4-0.3-0.80.10.7-0.8-1.0-0.7
Reaction time trials correct on left3.67.011.2-3.1-2.5-2.7-1.4-3.32.2-2.7-2.5-2.9
Reaction time trials on left3.76.911.3-3.2-2.4-2.7-1.3-3.42.2-2.7-2.5-2.9
Reaction time mean0.00.10.3-0.3-0.1-0.20.1-0.5-0.2-0.1-0.1-0.0
Reaction time mean AUC0.10.20.5-0.6-0.3-0.4-0.0-0.70.1-0.4-0.3-0.3
Median of all reaction times0.10.20.7-0.6-0.2-0.40.1-0.8-0.0-0.3-0.3-0.3
Reaction time omissions0.81.11.80.61.31.11.40.4-1.11.20.91.0
Reaction time false alarm rate0.60.93.11.20.91.1-0.01.8-0.50.50.40.8
Reaction time premature initiation rate1.52.14.8-0.4-1.8-1.7-2.2-0.61.2-1.7-1.0-1.5
Reaction time premature initiations4.17.49.3-2.2-3.0-3.0-2.7-2.52.4-3.0-2.4-3.0
Std. dev. reaction times0.00.00.20.2-0.1-0.1-0.50.10.0-0.2-0.1-0.2
Reaction time trials completed3.76.911.3-3.2-2.4-2.7-1.3-3.42.2-2.7-2.5-2.9
Reaction time trials AUC4.17.812.2-3.4-2.6-2.8-1.4-3.52.4-2.8-2.7-3.0
Run reversals in cocaine runway, females0.60.61.5-0.4-0.5-0.6-0.9-0.80.7-0.7-0.5-1.2
Run reversals in cocaine runway, males0.20.20.4-0.50.20.40.50.60.60.1-0.60.6
Latency to leave start box in cocaine runway0.91.01.7-0.9-0.9-0.7-1.2-0.01.1-1.3-1.3-0.9
Latency to leave start box in cocaine runway, F1.51.72.4-1.5-1.1-1.1-1.0-0.91.5-1.6-1.5-1.3
Latency to leave start box in cocaine runway, M0.20.20.70.1-0.4-0.2-0.90.60.2-0.5-0.4-0.2
Std. dev. time between licks in bursts1.41.94.4-2.1-1.3-1.4-0.4-2.00.6-1.4-1.2-1.1
Total sessions with >9 infusions0.10.10.5-0.1-0.4-0.3-0.7-0.00.2-0.2-0.3-0.5
Short access day 1 total inactive lever presses0.50.61.20.61.11.01.10.4-0.70.51.00.4
Short access day 10 total inactive lever presses0.30.84.0-0.70.80.42.0-1.0-0.40.50.50.7
Short access day 1 total infusions0.40.51.50.0-0.5-0.4-1.1-0.10.5-0.8-0.4-1.2
Short access day 10 total infusions0.20.20.7-0.9-0.5-0.40.3-0.40.6-0.2-0.6-0.2
Short access total infusions0.30.40.8-0.4-0.8-0.8-0.7-0.70.4-0.5-0.4-0.9
Short access day 1 locomotion0.10.10.50.50.20.3-0.30.70.2-0.20.1-0.2
Short access day 10 total locomotion0.20.31.30.40.50.70.11.20.10.3-0.10.6
Short access total locomotion0.40.51.10.80.60.80.21.1-0.40.60.50.7
One hour access (0.3 mA shock)1.21.42.2-1.2-1.5-1.5-0.9-1.30.5-1.1-1.1-1.1
Compulsive drug intake0.20.20.8-0.7-0.2-0.40.3-0.90.6-0.1-0.20.2
One hour access (shock baseline)0.10.20.4-0.2-0.7-0.5-0.4-0.1-0.2-0.6-0.4-0.6
Social response proportion0.10.10.5-0.3-0.2-0.4-0.2-0.70.00.1-0.2-0.2
Social responses0.10.10.5-0.2-0.0-0.20.2-0.7-0.00.2-0.0-0.1
Social time0.20.20.7-0.3-0.6-0.7-0.5-0.80.00.2-0.4-0.2
Soleus weight0.10.41.3-0.1-0.4-0.51.0-0.50.10.80.41.2
Bone: stiffness0.81.31.90.91.31.11.40.5-1.21.21.31.0
Tibialis anterior weight0.20.61.0-0.4-1.0-0.9-0.9-0.51.0-0.5-0.8-0.4
Time to tail flick, vehicle, before self-admin0.20.20.50.60.10.2-0.20.6-0.70.10.10.3
Time to tail flick, vehicle, after self-admin0.60.71.81.30.80.9-0.11.3-0.50.90.60.5
Time to tail flick, test, before self-admin0.10.10.50.20.10.2-0.40.7-0.0-0.2-0.2-0.0
Time to tail flick, test, after self-admin2.52.64.01.91.81.71.01.2-1.62.01.71.3
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.4-0.0-0.10.3-0.50.50.10.1-0.2
Delta time to tail flick, test, before/after SA1.71.72.81.71.51.40.80.9-1.41.51.60.8
Tibia length12.735.057.14.46.55.87.62.6-6.66.16.45.8
Ambulatory time before self-admin0.71.04.1-0.31.10.82.0-0.4-0.41.00.91.0
Ambulatory time after self-admin1.31.53.4-1.7-1.2-1.4-0.2-1.91.0-0.9-0.9-1.1
Bone: tissue strength1.41.43.4-1.9-1.2-1.30.2-1.61.2-0.7-1.2-0.3
Total heroin consumption0.60.82.40.30.90.81.00.2-0.71.60.80.9
Bone: trabecular number0.00.10.20.1-0.10.0-0.30.50.30.0-0.10.1
Bone: trabecular spacing0.91.25.3-1.6-0.4-0.80.4-2.30.3-0.5-0.7-1.0
Bone: trabecular thickness0.10.20.80.2-0.3-0.0-0.10.90.3-0.0-0.20.7
Bone: trabecular tissue density0.60.92.01.40.90.90.11.0-1.00.91.00.5
Water consumed over 24 hours0.00.10.3-0.1-0.10.1-0.10.60.2-0.2-0.20.1
Number of responses in last shaping day0.30.30.90.40.60.70.50.60.30.90.30.4