Tbc1d16

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Tbc1d16	0.09	0.06	1.7e-03	0.06	0.05	0.05	0.05	1.1e-03	2.6e-03	3.0e-03	3.0e-03
2	BLA	gene expression	Tbc1d16	0.08	0.06	4.3e-04	0.02	0.03	0.07	0.04	3.7e-02	1.1e-02	1.2e-04	5.5e-03
3	Brain	gene expression	Tbc1d16	0.1	0.05	6.7e-10	0.09	0.11	0.07	0.1	7.0e-09	2.8e-10	4.7e-07	9.9e-10
4	PL	gene expression	Tbc1d16	0.22	0.13	1.1e-13	0.12	0.12	0.12	0.12	3.2e-13	8.0e-13	1.9e-13	1.2e-13
5	NAcc	mRNA stability	Tbc1d16	0.08	0.05	1.5e-06	0.06	0.04	0.05	0.06	7.5e-08	5.8e-06	6.6e-07	5.0e-07
6	Adipose	gene expression	Tbc1d16	0.07	0.04	1.2e-07	0.05	0.07	0.06	0.06	7.6e-06	6.1e-08	5.7e-07	1.3e-07
7	NAcc	gene expression	Tbc1d16	0.06	0.03	1.1e-06	0.02	0.05	0.05	0.05	1.2e-03	1.4e-06	2.4e-06	3.8e-06
8	Liver	gene expression	Tbc1d16	0.1	0.06	1.1e-08	0.04	0.07	0.06	0.07	5.5e-05	6.8e-08	3.1e-07	3.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.5	0.8	1.4	0.8	0.5	-1.1	-1.0	-1.2	-0.8	-0.9	-0.6
Area under the delay curve	2.1	2.3	3.5	-1.9	-0.6	1.8	1.7	1.7	0.9	1.2	1.7
BMI with tail	0.3	1.1	3.3	0.8	0.2	-1.2	-0.7	-0.9	0.4	-1.8	-1.5
BMI without tail	2.1	4.4	11.0	1.8	0.5	-2.3	-1.4	-1.3	1.0	-3.3	-3.3
Body weight	1.0	4.3	15.9	-1.6	-2.6	0.9	1.9	2.0	4.0	-0.5	-0.7
Weight adjusted by age	0.6	0.7	2.3	-0.5	-1.5	0.2	0.6	0.5	1.5	-0.1	-0.4
Bone surface	0.4	0.7	1.5	-1.2	-0.5	0.8	0.7	0.9	0.7	0.8	0.9
Bone volume	0.0	0.0	0.1	-0.1	0.2	-0.3	-0.3	-0.2	-0.1	-0.2	-0.1
Breakpoint value in progressive ratio session	0.6	0.7	1.3	0.8	0.3	-1.0	-0.8	-0.8	-0.1	-1.1	-1.1
Number of licking bursts	0.1	0.1	0.3	-0.2	-0.4	0.2	0.2	0.2	0.6	-0.0	-0.0
Context. condit. distance diff. score	0.7	0.9	2.8	0.7	0.8	-0.7	-0.6	0.1	0.5	-1.3	-1.7
Locomotion velocity, session 1	2.3	2.5	6.0	-1.2	-0.5	2.0	1.2	1.1	-0.1	2.3	2.4
Locomotion distance, session 1	1.3	1.7	3.1	1.3	1.5	-1.1	-1.4	-1.6	-1.7	-0.8	-0.3
Locomotion velocity, session 2	1.0	1.2	4.2	0.6	1.2	-0.1	-0.9	-1.0	-2.1	0.8	1.0
Locomotion distance, session 2	2.5	3.5	6.6	2.2	1.1	-2.0	-1.9	-2.6	-1.9	-1.6	-1.2
Locomotion velocity, session 3	0.5	0.6	1.6	-0.6	0.0	1.0	0.4	0.5	-0.3	1.3	1.2
Locomotion distance, session 3	0.5	0.6	2.0	0.7	1.1	-0.1	-0.6	-0.6	-1.4	0.2	0.5
Stereotopy head waving bouts, day 3	0.3	0.4	0.9	-0.7	0.0	0.9	0.5	0.7	0.3	0.9	0.7
Stereotopy head waving duration, day 3	0.3	0.3	0.6	-0.7	0.3	0.8	0.3	0.7	0.4	0.7	0.3
Locomotion velocity, session 7	0.1	0.2	0.8	-0.2	0.9	0.4	-0.0	0.1	-0.2	0.3	0.3
Locomotion distance, session 7	3.2	4.0	11.5	1.9	3.4	-1.5	-2.0	-1.6	-2.0	-1.4	-1.5
Stereotopy head waving bouts, day 7	0.4	0.5	1.6	-0.6	-0.5	0.7	0.5	1.0	1.3	0.1	-0.2
Stereotopy head waving duration, day 7	1.7	2.0	3.6	-1.5	-1.6	1.4	1.4	1.6	1.9	0.9	0.7
Locomotion velocity, session 8	0.4	0.5	1.2	-1.0	1.1	0.5	0.4	0.9	0.8	-0.2	-0.1
Locomotion distance, session 8	3.7	5.4	8.2	2.5	2.0	-2.5	-2.3	-2.1	-1.0	-2.8	-2.9
Degree of sensitization distance	1.8	1.8	3.6	1.1	1.3	-1.5	-1.3	-1.1	-0.4	-1.6	-1.9
Degree of sensitization stereotypy	0.3	0.3	1.3	-0.3	-0.4	0.2	0.2	0.5	1.1	-0.3	-0.5
Conditioned locomotion	0.8	1.0	2.9	0.2	-0.5	-1.1	-0.2	-0.4	0.9	-1.7	-1.6
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.1	-0.1	0.2	0.2	0.2	0.0	0.2	0.3
Cocaine response after cond. not corrected	0.2	0.2	0.5	-0.1	0.2	0.6	0.3	0.5	-0.2	0.7	0.7
Cocaine response before conditioning	0.3	0.3	0.6	-0.2	0.5	0.6	0.3	0.8	-0.3	0.8	0.6
Saline control response	0.7	0.9	3.2	-0.6	-1.4	0.7	0.6	0.7	1.8	0.3	-0.2
Bone: connectivity density	0.2	0.3	0.5	-0.1	0.6	-0.7	-0.5	-0.6	-0.7	-0.6	-0.1
Bone: cortical apparent density	1.4	1.8	5.3	1.1	1.5	-1.1	-1.3	-1.6	-2.3	-0.4	0.1
Bone: cortical area	2.5	3.8	9.0	-2.2	-3.0	1.1	2.0	1.8	2.8	0.4	0.5
Bone: cortical porosity	1.5	1.7	3.1	-0.7	-1.4	1.6	1.3	1.1	1.2	1.8	1.1
Bone: cortical porosity	1.6	1.8	2.4	-1.0	-1.4	1.5	1.4	1.3	1.5	1.5	0.9
Bone: cortical thickness	1.5	2.5	11.0	-1.3	-3.3	0.4	1.5	0.9	2.0	0.1	0.4
Bone: cortical thickness	0.9	1.0	2.5	-1.3	-1.6	0.2	1.2	0.8	1.1	-0.2	0.4
Bone: cortical tissue density	1.5	2.0	5.9	1.1	1.7	-1.1	-1.4	-1.6	-2.4	-0.4	0.1
Condit. Reinf. active minus inactive responses	0.4	0.5	1.0	0.1	-0.9	-0.8	0.1	-0.4	0.5	-1.0	-0.9
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.4	-0.0	-0.3	-0.9	0.1	-0.3	0.2	-1.2	-0.9
Condit. Reinf. active responses	0.6	0.7	1.4	0.3	-1.2	-1.0	-0.1	-0.6	0.7	-1.2	-1.1
Condit. Reinf. inactive responses	0.3	0.3	0.7	0.7	-0.5	-0.6	-0.6	-0.8	0.1	-0.5	-0.6
Incentive salience index mean	0.3	0.4	1.1	0.1	-1.1	-0.6	0.2	-0.2	0.6	-0.8	-0.7
Condit. Reinf. lever presses	0.2	0.3	0.5	0.7	-0.0	-0.6	-0.5	-0.6	-0.2	-0.6	-0.6
Condit. Reinf. active minus inactive responses	1.2	1.4	3.9	-1.3	-2.0	0.7	1.2	1.0	1.7	0.0	0.2
Condit. Reinf. active-inactive response ratio	1.2	1.3	4.7	-0.8	-2.2	0.8	1.0	0.7	1.7	0.3	0.3
Condit. Reinf. active responses	0.2	0.3	1.0	-0.2	-0.7	-0.4	-0.1	-0.2	0.5	-1.0	-0.8
Condit. Reinf. inactive responses	0.9	1.1	1.5	0.7	1.2	-1.2	-1.0	-1.0	-1.1	-1.2	-1.0
Condit. Reinf. lever presses	1.8	2.5	4.3	1.3	1.0	-1.7	-1.6	-1.6	-0.5	-2.1	-2.1
Condit. Reinf. lever reinforcers received	0.6	0.8	2.7	0.3	-0.2	-1.0	-0.6	-0.7	0.2	-1.6	-1.4
Conditioned reinforcement - actives	0.3	0.3	0.7	0.8	-0.1	-0.7	-0.5	-0.5	-0.2	-0.5	-0.7
Conditioned reinforcement - inactives	0.2	0.3	1.0	-0.2	-0.7	0.1	0.2	0.6	1.0	-0.1	-0.4
Conditioned locomotion	0.3	0.4	0.8	0.9	-0.3	-0.7	-0.7	-0.7	-0.2	-0.4	-0.7
Patch foraging indifference point 0 sec	1.8	2.9	4.1	1.8	1.2	-1.9	-1.9	-2.0	-1.1	-1.7	-1.8
Patch foraging indifference point AUC	0.1	0.2	0.3	0.3	0.5	-0.5	-0.3	-0.3	-0.2	-0.5	-0.5
Delay disc. indifference point, 0s delay	1.9	2.1	3.2	-1.5	-1.1	1.6	1.7	1.8	1.5	1.0	1.0
Delay disc. indifference point, 16s delay	0.3	0.3	1.0	0.1	1.0	-0.5	-0.5	-0.5	-0.6	-0.8	-0.2
Delay disc. indifference point, 2s delay	2.1	2.3	3.4	-1.8	-1.3	1.6	1.7	1.7	1.2	1.1	1.5
Delay disc. indifference point, 24s delay	0.7	0.6	2.1	-0.4	0.5	0.7	0.1	-0.1	-1.1	1.0	1.4
Delay disc. indifference point, 4s delay	2.5	2.7	3.9	-2.0	-1.0	1.9	1.9	2.0	1.6	1.1	1.4
Delay disc. indifference point, 8s delay	5.6	5.8	7.8	-2.7	-1.4	2.8	2.8	2.7	1.6	2.2	2.6
Indifference point function ln k	1.0	1.3	2.2	1.1	1.4	-0.9	-1.4	-1.4	-1.5	-0.6	-0.6
Indifference point function log k	1.0	1.3	2.2	1.1	1.4	-0.9	-1.4	-1.4	-1.5	-0.6	-0.6
Patch foraging total patch changes 0 sec	2.6	4.2	5.8	2.1	1.5	-2.4	-2.2	-2.4	-1.3	-2.1	-2.2
Patch foraging total patch changes 12 sec	2.2	2.8	4.3	2.1	1.1	-1.8	-1.8	-2.1	-1.3	-1.4	-1.6
Patch foraging total patch changes 18 sec	2.6	3.3	5.0	1.7	1.6	-2.1	-1.7	-1.8	-1.1	-2.2	-2.0
Patch foraging total patch changes 24 sec	0.4	0.5	1.4	0.4	-0.2	-0.7	-0.2	-0.3	0.6	-1.1	-1.2
Patch foraging total patch changes 6 sec	0.9	1.3	2.5	1.3	0.2	-1.4	-1.2	-1.6	-0.8	-0.9	-1.0
Patch foraging time to switch 0 sec	0.3	0.4	1.1	-0.3	-0.2	0.9	0.3	0.3	-0.1	1.0	1.0
Patch foraging water rate 0 sec	1.1	1.7	5.0	0.4	0.2	-1.5	-0.4	-0.6	1.0	-2.2	-2.2
Patch foraging water rate 12 sec	2.5	3.8	6.1	2.1	1.5	-2.1	-1.9	-1.9	-0.8	-2.3	-2.5
Patch foraging water rate 18 sec	1.6	2.2	4.7	1.5	0.9	-1.7	-1.4	-1.1	0.0	-1.9	-2.2
Patch foraging water rate 24 sec	5.2	7.3	15.1	2.4	1.7	-3.1	-2.5	-2.2	-0.2	-3.7	-3.9
Patch foraging water rate 6 sec	0.5	0.7	1.5	0.9	0.4	-0.9	-0.7	-0.6	-0.0	-1.2	-1.0
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	2.6	-1.1	-1.6	0.5	1.0	0.6	1.0	0.4	0.6
Distance traveled before self-admin	1.5	1.6	2.8	-1.5	-1.5	1.1	1.3	1.4	1.7	0.5	0.6
Distance traveled after self-admin	1.8	2.0	3.1	1.4	0.8	-1.7	-1.5	-1.3	-0.6	-1.7	-1.8
Extensor digitorum longus weight	1.8	6.9	9.3	2.7	2.4	-2.9	-2.7	-2.5	-1.6	-2.9	-3.0
Bone: elastic displacement	0.6	0.7	1.2	0.7	-0.8	-1.1	-0.6	-1.0	-0.1	-1.0	-0.9
Bone: elastic work	1.0	1.3	6.5	-0.8	-2.6	0.1	0.9	0.4	1.6	0.0	0.0
Bone: endosteal estimation	0.1	0.2	1.2	-0.3	1.1	-0.2	-0.3	0.0	0.2	-0.4	-0.6
Bone: endosteal perimeter	1.4	3.0	5.2	-2.3	-1.1	1.7	1.8	2.1	1.9	1.3	1.1
Epididymis fat weight	0.3	0.6	1.5	0.1	-0.2	-0.6	-0.1	-0.1	1.1	-1.2	-1.2
Delta time in closed arm before/after self-admin	0.9	0.9	1.2	-1.1	-1.0	1.0	1.1	0.8	0.9	0.8	1.0
Delta time in open arm before/after self-admin	1.0	0.9	1.9	0.8	0.5	-1.2	-0.9	-1.0	-0.4	-1.4	-1.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.0	0.0	-0.2	-0.1
Delay discount exponential model param	2.5	2.6	3.9	2.0	0.6	-1.9	-1.8	-1.8	-0.8	-1.4	-2.0
Extinction: sum of active levers before priming	0.5	0.5	1.2	0.7	1.0	-0.6	-0.9	-0.7	-1.1	-0.4	-0.2
Active lever presses in extinction session 6	0.1	0.1	0.4	-0.1	0.1	-0.4	-0.0	-0.2	0.2	-0.6	-0.5
Bone: final force	1.8	2.9	7.4	-1.8	-2.7	0.8	1.6	1.3	2.7	0.1	0.2
Bone: final moment	1.7	2.7	7.6	-1.7	-2.7	0.7	1.5	1.1	2.8	0.0	0.0
Food consumed during 24 hour testing period	0.3	0.3	0.8	-0.5	-0.0	-0.2	0.2	0.3	0.9	-0.8	-0.9
Glucose	0.6	0.9	3.0	0.4	0.3	0.4	-0.5	-0.5	-1.7	1.3	1.3
Heart weight	0.2	0.3	0.6	0.7	0.1	-0.6	-0.6	-0.6	0.0	-0.5	-0.7
Delay discount hyperbolic model param	2.5	2.7	4.0	2.0	0.7	-1.9	-1.9	-1.8	-0.9	-1.4	-1.9
Intermittent access intake day 1-15 change	0.4	0.4	0.9	-0.8	-0.4	0.6	0.6	1.0	0.8	0.3	0.2
Intermittent access intake escalation	0.3	0.2	0.6	-0.6	-0.3	0.4	0.5	0.8	0.7	0.1	0.0
Intermittent access intake escalation 2	0.6	0.6	1.1	-0.7	-0.9	0.8	0.6	0.8	1.0	0.6	0.4
Intermitt. access day 1 inactive lever presses	0.7	0.8	2.1	-0.7	-0.9	0.5	0.9	1.2	1.4	0.0	-0.2
Intermitt. access day 15 inactive lever presses	0.5	0.5	1.5	0.4	-0.2	-0.7	-0.3	-0.1	0.6	-1.1	-1.2
Intermitt. access escalation Index	0.3	0.2	0.8	-0.2	-0.6	-0.1	0.5	0.3	0.9	-0.4	-0.5
Intermittent access day 1 total infusions	0.2	0.3	0.5	0.7	-0.0	-0.7	-0.6	-0.5	-0.3	-0.5	-0.6
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.0	-0.4	-0.2	0.1	0.4	0.4	-0.3	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.7	-0.1	-0.8	0.0	0.2	0.5	0.6	-0.0	-0.2
Intermittent access total infusions	0.1	0.1	0.3	0.4	-0.3	-0.5	-0.3	-0.0	0.1	-0.4	-0.6
Intermittent access day 1 locomotion	0.5	0.5	0.9	0.8	0.2	-0.9	-0.7	-0.7	-0.2	-0.8	-1.0
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.1	-0.5	0.2	0.3	0.4	0.4	0.2	-0.0
Intermittent access total locomotion	0.2	0.2	0.6	0.6	-0.0	-0.6	-0.4	-0.2	0.1	-0.5	-0.8
Intermittent access standard deviation	2.1	2.2	3.4	-1.7	-1.0	1.7	1.5	1.9	1.2	1.3	1.4
Left kidney weight	2.3	6.6	8.2	-2.6	-2.4	2.9	2.7	2.8	2.5	2.4	2.1
Right kidney weight	1.4	3.8	4.9	-2.2	-2.0	2.0	2.2	2.1	2.0	1.4	1.6
Cocaine induced anxiety	2.0	2.3	6.0	-1.2	-2.0	1.0	1.8	1.6	2.5	0.3	0.0
Post-drug Anxiety	0.4	0.4	1.6	-0.4	-0.1	0.2	0.6	0.7	1.2	-0.5	-0.5
Baseline Anxiety	1.1	1.2	4.2	0.5	2.0	-0.2	-1.0	-0.7	-1.8	0.1	0.5
Tail length	0.9	2.6	10.8	-0.6	-2.1	0.1	1.0	1.2	3.3	-0.9	-1.4
Length with tail	2.4	8.8	18.6	-2.9	-3.4	2.6	3.1	3.4	4.3	1.6	1.1
Length without tail	3.9	8.6	10.6	-3.2	-2.4	3.3	3.1	3.1	2.2	3.0	2.9
Times rat made contact with spout	0.2	0.3	1.0	0.4	-1.0	-0.3	-0.2	-0.5	0.3	-0.1	-0.5
Lifetime Intake	0.0	0.0	0.1	0.2	-0.3	-0.2	-0.1	0.1	0.0	-0.1	-0.2
Liver weight, left	1.9	3.1	4.0	-1.8	-1.4	2.0	1.8	1.9	1.2	1.9	1.8
Liver weight, right	2.5	4.1	8.7	-2.3	-3.0	1.6	2.2	1.7	2.4	1.2	1.3
Locomotor activity	0.1	0.1	0.3	0.1	0.6	0.0	-0.4	-0.2	-0.4	0.1	0.1
Locomotor testing distance	0.0	0.1	0.4	0.2	0.6	-0.1	-0.3	-0.0	-0.2	-0.2	-0.1
Locomotor testing rearing	0.8	1.3	2.5	0.8	0.8	-1.3	-1.2	-1.1	-0.4	-1.6	-1.4
Locomotion in novel chamber	0.3	0.4	0.6	0.6	0.7	-0.6	-0.6	-0.4	-0.2	-0.7	-0.7
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.5	0.1	-0.2	-0.5	-0.4	0.1	0.1	-0.4
Fecal boli incidents, locomotor time 1	0.9	1.0	2.1	1.1	0.8	-1.0	-1.1	-1.3	-1.5	-0.5	-0.4
Change in fecal boli incidents, locomotor task	0.7	0.7	2.1	0.4	1.4	0.0	-0.5	-0.4	-1.5	0.5	0.7
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	0.0	0.9	-0.4	-0.1	0.0	0.1	-0.9	-0.7
Bouts of movement, locomotor time 1	0.6	0.7	2.4	0.8	1.1	-0.5	-0.7	-0.6	-1.6	0.0	0.3
Total resting periods, locomotor time 1	0.8	0.9	3.4	1.0	1.2	-0.5	-0.8	-0.8	-1.8	0.2	0.4
Rest time, locomotor task time 1	0.2	0.2	0.5	0.5	-0.2	0.1	-0.3	-0.1	-0.6	0.7	0.5
Distance moved, locomotor task time 1	0.2	0.2	0.8	-0.5	-0.2	0.0	0.3	0.2	0.9	-0.4	-0.4
Vertical activity count, locomotor time 1	0.4	0.4	1.2	0.2	0.2	-0.7	-0.2	-0.3	0.4	-1.1	-1.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.2	0.4	0.2	-0.1	-0.1	-0.3	-0.1	-0.1	-0.2
Bouts of movement, locomotor time 2	0.2	0.2	0.7	-0.1	0.7	-0.0	-0.0	-0.1	-0.8	0.1	0.5
Total resting periods, locomotor time 2	0.1	0.1	0.5	-0.0	0.7	-0.1	-0.0	-0.1	-0.7	0.0	0.3
Rest time, locomotor task time 2	0.1	0.1	0.2	0.2	0.1	0.2	0.1	0.3	-0.2	0.4	0.3
Distance moved, locomotor task time 2	0.4	0.4	0.9	-0.9	-0.8	0.6	0.6	0.4	0.9	0.3	0.4
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.4	-0.2	-0.1	0.1	-0.0	0.5	-0.6	-0.4
Light reinforcement 1	1.4	2.6	5.3	1.5	-0.0	-2.0	-1.4	-1.7	-0.2	-2.1	-2.3
Light reinforcement 2	0.4	0.6	2.3	-0.2	-1.5	-0.0	0.4	0.2	1.3	-0.4	-0.6
Bone: marrow area	0.1	0.2	1.0	-0.3	1.0	-0.1	-0.2	0.1	0.2	-0.4	-0.5
Bone: maximum diameter	3.0	5.5	8.6	-2.9	-2.1	2.2	2.6	2.7	2.9	1.5	1.2
Bone: maximum force	1.2	2.1	5.9	-1.4	-2.4	0.5	1.2	1.1	2.4	-0.1	-0.0
Bone: maximum moment	1.1	1.9	5.8	-1.2	-2.4	0.4	1.1	0.8	2.4	-0.2	-0.3
Mean time between licks in bursts	0.2	0.2	0.9	0.0	0.9	0.2	-0.4	-0.3	-0.7	0.4	0.3
Mean num. licks in bursts	0.5	0.5	1.0	0.7	0.1	-0.9	-0.8	-1.0	-0.6	-0.6	-0.8
Cd content in liver	1.2	1.3	1.9	0.7	1.4	-1.2	-1.2	-1.2	-1.3	-1.3	-0.6
Co content in liver	1.2	1.4	2.0	1.2	1.0	-1.4	-1.3	-1.0	-1.1	-1.2	-1.1
Cu content in liver	0.1	0.2	0.4	-0.3	-0.6	0.3	0.4	0.2	0.1	0.6	0.5
Fe content in liver	0.4	0.4	1.6	0.6	1.3	-0.3	-0.8	-0.4	-0.6	-0.1	-0.4
K content in liver	0.2	0.2	0.6	-0.1	-0.4	-0.3	-0.0	-0.1	0.8	-0.5	-0.7
Mg content in liver	1.9	1.9	2.5	1.4	1.1	-1.6	-1.5	-1.6	-0.9	-1.4	-1.5
Mn content in liver	1.3	1.5	2.2	-1.5	-0.9	1.4	1.3	1.5	1.3	1.1	0.7
Na content in liver	0.6	0.7	1.0	-0.8	-1.0	0.8	0.8	0.7	0.5	0.9	0.9
Rb content in liver	1.3	1.6	3.1	1.0	0.4	-1.5	-1.2	-1.3	-0.2	-1.8	-1.7
Se content in liver	0.1	0.1	0.3	-0.1	0.2	-0.2	-0.1	0.2	0.5	-0.5	-0.5
Sr content in liver	0.5	0.4	1.3	-0.2	-0.7	0.5	0.3	0.0	-0.3	1.1	1.1
Zn content in liver	0.8	0.9	1.9	-0.7	-1.0	1.0	0.8	0.7	0.2	1.3	1.4
Bone: minimum diameter	0.9	1.7	5.4	-1.3	-1.7	0.7	1.1	1.3	2.3	0.1	-0.2
Time in familiar zone, hab. session 1	0.6	0.6	0.8	0.8	0.6	-0.9	-0.8	-0.7	-0.8	-0.6	-0.6
Time in novel zone, hab. session 1	1.0	1.0	1.7	-1.2	-0.6	1.1	1.1	1.3	1.1	0.6	0.7
Total zone transitions, hab. session 1	1.4	1.9	2.7	1.6	1.2	-1.4	-1.4	-1.6	-1.2	-1.3	-1.2
Total locomotion distance, hab. session 1	1.1	1.6	3.2	1.0	0.7	-1.5	-1.2	-1.2	-0.4	-1.8	-1.6
Locomotion velocity, hab. session 1	1.5	2.1	3.3	1.4	0.9	-1.7	-1.4	-1.6	-0.6	-1.8	-1.7
Time in familiar zone, hab. session 2	0.5	0.5	0.8	0.9	0.9	-0.6	-0.8	-0.5	-0.5	-0.6	-0.8
Time in novel zone, hab. session 2	0.3	0.3	0.5	-0.7	-0.3	0.5	0.7	0.5	0.2	0.5	0.6
Total zone transitions, hab. session 2	5.0	6.5	9.3	3.1	1.9	-2.6	-2.8	-2.9	-2.0	-2.4	-2.4
Total locomotion distance, hab. session 2	4.3	5.6	7.7	2.7	1.0	-2.7	-2.5	-2.8	-1.4	-2.6	-2.6
Locomotion velocity, hab. session 2	3.6	4.8	6.9	2.5	0.7	-2.5	-2.3	-2.6	-1.1	-2.5	-2.5
Novel to familiar place preference ratio	2.2	2.2	3.7	1.7	-0.7	-1.9	-1.3	-1.9	-0.6	-1.6	-1.6
Novelty place preference	1.7	1.8	2.8	1.6	-0.8	-1.6	-1.1	-1.7	-0.5	-1.4	-1.4
Time in novel zone, NPP test	2.1	2.2	3.4	1.8	-0.5	-1.9	-1.3	-1.8	-0.7	-1.6	-1.6
Total zone transitions, NPP test	2.8	4.0	5.6	2.1	1.8	-2.1	-2.1	-2.4	-1.6	-2.0	-1.9
Total locomotion distance, NPP test	5.7	7.8	10.7	2.9	1.7	-3.2	-2.9	-3.3	-1.9	-3.1	-2.9
Locomotion velocity, NPP test	4.5	6.4	9.3	2.7	1.3	-2.9	-2.6	-3.0	-1.6	-2.8	-2.6
Intraocular pressure	1.4	2.0	3.0	1.2	0.9	-1.7	-1.5	-1.7	-0.8	-1.7	-1.5
Delta distance traveled before/after self-admin	3.5	3.8	4.9	2.1	1.7	-2.2	-2.0	-2.0	-1.5	-2.0	-2.0
Delta ambulatory time before/after self-admin	3.7	4.0	5.1	2.3	2.0	-2.1	-2.1	-2.1	-1.9	-1.7	-1.7
Parametrial fat weight	0.2	0.3	1.2	0.2	-0.7	-0.0	0.3	0.3	1.1	-0.2	-0.6
Pavlov. Cond. lever latency	1.7	2.2	5.5	0.9	2.3	-1.4	-1.3	-0.7	-1.0	-1.8	-1.7
Pavlov. Cond. magazine entry latency	2.2	2.8	4.6	-1.5	-2.1	1.7	1.8	1.7	2.2	1.4	0.9
Pavlov. Cond. change in total contacts	0.3	0.3	0.9	0.6	-0.5	-0.5	-0.4	-1.0	-0.5	-0.0	-0.0
Pavlov. Cond. index score	2.0	2.5	6.6	-1.1	-2.6	1.4	1.5	1.2	2.0	1.2	0.9
Pavlov. Cond. latency score	2.5	3.2	7.3	-1.4	-2.7	1.7	1.7	1.4	2.0	1.7	1.3
Pavlov. Cond. lever contacts	0.5	0.5	2.8	-0.1	-1.7	0.4	0.4	-0.1	0.4	0.8	0.7
Pavlov. Cond. magazine entry number	2.3	2.9	4.0	1.4	2.0	-1.8	-1.8	-1.7	-2.0	-1.7	-1.1
Pavlov. Cond. intertrial magazine entries	1.8	2.2	3.2	1.6	0.9	-1.8	-1.4	-1.6	-1.2	-1.6	-1.6
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	5.9	-0.9	-2.4	1.1	1.3	0.9	1.9	0.9	0.6
Pavlov. Cond. response bias	1.4	1.8	3.9	-1.0	-2.0	1.2	1.4	1.0	1.5	1.3	0.9
Pavlov. Cond. lever latency	2.6	3.5	6.4	-1.9	-0.9	2.1	1.9	1.8	0.5	2.3	2.5
Pavlov. Cond. magazine entry latency	3.5	4.0	6.6	2.1	2.6	-2.0	-2.0	-1.6	-1.7	-2.1	-1.8
Pavlov. Cond. change in total contacts	2.8	3.9	5.5	1.9	1.7	-2.2	-2.1	-2.0	-1.4	-2.3	-2.1
Pavlov. Cond. index score	3.0	3.9	5.8	2.0	1.8	-2.2	-2.0	-1.7	-1.1	-2.4	-2.3
Pavlov. Cond. latency score	2.8	3.4	5.5	1.8	1.7	-2.1	-1.8	-1.5	-0.9	-2.3	-2.2
Pavlov. Cond. lever contacts	2.3	3.2	6.4	1.8	0.8	-2.0	-1.7	-1.7	-0.3	-2.4	-2.5
Pavlov. Cond. magazine entry number	4.0	4.9	6.0	-2.4	-2.5	2.4	2.3	1.8	1.8	2.4	2.1
Pavlov. Cond. intertrial magazine entries	0.7	0.9	2.4	-1.1	-1.3	0.6	0.8	0.6	1.6	0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.3	5.9	2.2	2.0	-2.3	-2.1	-1.8	-1.3	-2.4	-2.3
Pavlov. Cond. response bias	2.7	3.7	5.7	2.2	1.3	-2.1	-1.9	-1.8	-0.9	-2.4	-2.4
Time in closed arm before self-admin	0.1	0.1	0.3	0.1	0.5	0.3	-0.0	0.2	-0.5	0.5	0.5
Time in closed arm after self-admin	1.2	1.3	2.7	-0.9	-0.2	1.4	1.1	1.0	0.1	1.6	1.6
Time in open arm before self-admin	0.6	0.6	0.8	-0.9	-0.9	0.9	0.8	0.7	0.6	0.8	0.8
Time in open arm after self-admin	0.3	0.3	0.4	0.4	0.3	-0.6	-0.7	-0.6	-0.3	-0.6	-0.6
Bone: periosteal estimation	0.7	1.4	3.9	-1.6	-1.3	0.7	1.2	1.3	2.0	0.1	-0.0
Bone: periosteal perimeter	4.4	7.3	10.4	-3.2	-3.0	2.4	2.9	2.9	2.9	2.0	1.9
Bone: post-yield work	0.7	0.9	1.6	0.7	0.7	-1.3	-0.9	-1.1	-1.0	-1.1	-0.7
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	0.3	-0.3	-0.6	-0.2	-0.1	0.1	-0.5	-0.8
Progressive ratio test 1 breakpoint	0.2	0.3	0.8	0.4	-0.2	-0.7	-0.3	-0.2	-0.0	-0.6	-0.9
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.9	-0.4	-1.1	-0.2	0.5	0.7	1.4	-0.7	-0.9
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.1	0.2	0.2	-0.2	-0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.3	-0.2	-0.3	-0.2	0.2	0.2	-0.3	-0.6
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.5	-0.3	-0.6	0.3	0.3	0.7	0.7	0.1	-0.1
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.2	-0.4	0.4	0.1	0.4	0.3	0.4	0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.3	-0.4	0.5	0.2	0.5	0.4	0.5	0.3
Sum of active levers in priming session hrs 5-6	0.4	0.3	0.8	0.5	0.1	-0.8	-0.4	-0.5	-0.1	-0.9	-0.8
Progressive ratio	0.6	0.7	1.5	1.2	0.6	-0.7	-0.9	-1.1	-1.1	-0.3	-0.3
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.0	-0.1	0.3	0.2	0.1	0.1	0.1	0.1
Seeking ratio, punishment vs. effort	0.5	0.6	1.1	-1.1	-0.4	0.6	0.9	1.0	1.0	0.1	0.3
Retroperitoneal fat weight	0.8	2.7	10.7	-0.6	-1.6	-0.2	0.9	1.0	3.3	-1.4	-1.9
Reaction time number correct	5.4	7.7	11.9	3.1	2.7	-2.9	-2.8	-2.2	-1.0	-3.3	-3.5
Reaction time mean minus median	0.6	0.8	1.4	-0.8	-0.7	1.0	1.0	1.0	0.2	1.2	0.9
Reaction time mean minus median AUC	1.1	1.5	2.2	-1.2	-1.3	1.3	1.5	1.3	1.1	1.1	0.8
Reaction time num false alarms	0.3	0.5	0.9	0.8	0.8	-0.4	-0.7	-0.9	-0.7	-0.2	-0.3
Reaction time num false alarms AUC	0.5	0.6	1.5	0.9	1.2	-0.4	-0.8	-1.0	-0.9	-0.3	-0.3
Reaction time trials correct on left	5.4	7.7	11.9	3.1	2.7	-2.9	-2.8	-2.2	-1.0	-3.3	-3.5
Reaction time trials on left	5.4	7.7	12.1	3.1	2.7	-2.9	-2.8	-2.2	-0.9	-3.3	-3.5
Reaction time mean	0.1	0.1	0.2	-0.0	-0.0	-0.1	0.2	0.2	0.4	-0.4	-0.5
Reaction time mean AUC	0.1	0.2	0.5	0.2	0.1	-0.4	-0.0	0.0	0.2	-0.7	-0.7
Median of all reaction times	0.1	0.2	0.6	0.2	0.2	-0.4	-0.0	-0.0	0.4	-0.8	-0.7
Reaction time omissions	0.5	0.6	1.4	-0.6	-0.7	0.7	0.9	1.2	1.2	0.2	0.0
Reaction time false alarm rate	0.6	0.8	2.1	-0.7	-0.2	1.1	0.6	0.2	-0.4	1.4	1.4
Reaction time premature initiation rate	2.1	2.8	4.9	1.9	1.9	-1.5	-1.8	-1.9	-2.2	-0.9	-0.9
Reaction time premature initiations	6.2	8.8	11.3	3.4	3.3	-3.0	-3.1	-2.9	-2.5	-2.6	-2.8
Std. dev. reaction times	0.1	0.1	0.4	0.1	0.6	0.0	0.1	0.2	-0.4	0.0	-0.2
Reaction time trials completed	5.4	7.7	12.1	3.1	2.7	-2.9	-2.8	-2.2	-0.9	-3.3	-3.5
Reaction time trials AUC	5.9	8.4	13.0	3.3	2.8	-3.0	-2.9	-2.4	-1.0	-3.4	-3.6
Run reversals in cocaine runway, females	1.0	1.0	2.2	0.8	1.5	-0.9	-1.1	-0.9	-0.7	-1.1	-0.8
Run reversals in cocaine runway, males	0.2	0.2	0.6	0.1	-0.7	0.5	0.4	0.2	0.3	0.8	0.3
Latency to leave start box in cocaine runway	0.8	0.9	1.6	1.1	1.0	-0.7	-1.1	-1.0	-1.3	-0.2	-0.3
Latency to leave start box in cocaine runway, F	0.9	1.0	1.5	1.2	1.2	-0.9	-1.2	-1.0	-0.9	-0.7	-0.8
Latency to leave start box in cocaine runway, M	0.8	0.8	1.7	0.9	0.5	-0.8	-1.1	-1.2	-1.3	-0.1	-0.1
Std. dev. time between licks in bursts	1.1	1.3	3.4	0.7	0.6	-1.4	-0.8	-1.0	-0.0	-1.9	-1.6
Total sessions with >9 infusions	0.3	0.3	0.6	-0.5	-0.2	0.6	0.5	0.6	-0.1	0.7	0.7
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.4	-0.7	0.4	0.3	0.4	0.6	0.3	0.1
Short access day 10 total inactive lever presses	1.0	1.1	3.9	-1.0	-1.2	0.5	1.0	1.0	2.0	-0.2	-0.3
Short access day 1 total infusions	0.1	0.1	0.3	-0.1	0.4	0.3	-0.1	-0.0	-0.5	0.4	0.6
Short access day 10 total infusions	0.1	0.1	0.5	-0.0	-0.7	-0.0	0.1	0.3	0.3	0.0	-0.1
Short access total infusions	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.2	-0.1	-0.3	0.0	-0.0
Short access day 1 locomotion	0.5	0.5	1.3	-0.5	-0.5	0.9	0.4	0.5	0.1	1.1	1.0
Short access day 10 total locomotion	0.4	0.4	1.0	-0.7	-0.4	0.8	0.4	0.3	0.1	1.0	0.9
Short access total locomotion	0.6	0.7	1.7	-0.6	-0.5	0.9	0.5	0.6	-0.1	1.3	1.2
One hour access (0.3 mA shock)	0.6	0.7	1.8	1.0	0.0	-1.0	-0.6	-0.4	0.1	-1.1	-1.3
Compulsive drug intake	0.5	0.5	1.3	0.8	0.4	-0.9	-0.2	-0.4	0.1	-1.1	-1.2
One hour access (shock baseline)	0.1	0.1	0.4	0.1	-0.6	0.0	-0.1	0.1	0.2	0.2	-0.0
Social response proportion	0.2	0.3	0.7	0.2	0.6	-0.5	-0.2	-0.4	-0.2	-0.8	-0.8
Social responses	0.1	0.1	0.6	-0.0	0.1	-0.2	0.1	0.1	0.4	-0.6	-0.8
Social time	0.3	0.5	1.1	0.6	0.3	-1.0	-0.3	-0.5	-0.6	-1.1	-0.7
Soleus weight	0.2	0.7	1.6	0.8	-1.3	-1.0	-0.4	-0.8	0.3	-0.8	-0.9
Bone: stiffness	1.0	1.5	2.3	-1.5	-1.4	1.1	1.3	1.3	1.5	0.7	0.8
Tibialis anterior weight	0.3	1.1	1.5	1.2	1.0	-1.1	-1.2	-1.1	-1.0	-0.7	-0.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	0.2	-0.1	-0.3	-0.3	-0.4	-0.2	-0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.9	-0.2	0.5	0.5	0.0	0.1	-0.8	0.9	1.0
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.2	-0.0	0.3	0.1	0.2	0.1	0.4	0.3
Time to tail flick, test, after self-admin	0.7	0.7	1.2	-1.0	-0.6	0.8	1.1	1.0	0.9	0.3	0.6
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.8	0.7	0.9	-0.7	-0.7	-0.6	-0.5	-0.6	-0.7
Delta time to tail flick, test, before/after SA	0.5	0.4	0.8	-0.8	-0.2	0.7	0.9	0.8	0.5	0.4	0.6
Tibia length	12.4	34.9	58.9	-6.4	-6.6	5.7	6.4	6.3	7.7	3.7	3.0
Ambulatory time before self-admin	2.2	2.2	4.8	-1.7	-1.7	1.2	1.7	1.7	2.2	0.4	0.4
Ambulatory time after self-admin	0.7	0.8	1.8	0.7	0.3	-1.1	-0.7	-0.7	0.0	-1.3	-1.3
Bone: tissue strength	2.0	2.0	3.5	1.6	-0.0	-1.7	-1.3	-1.6	-0.3	-1.7	-1.9
Total heroin consumption	0.9	1.1	1.7	-1.3	-1.3	0.9	1.2	1.1	1.0	0.5	0.7
Bone: trabecular number	0.0	0.1	0.2	-0.1	0.0	-0.1	-0.1	-0.4	-0.5	0.1	0.3
Bone: trabecular spacing	0.9	1.2	3.8	0.4	0.4	-0.8	-0.3	-0.1	1.0	-1.9	-1.9
Bone: trabecular thickness	0.2	0.3	0.5	0.2	-0.6	-0.1	-0.0	-0.5	-0.7	0.6	0.7
Bone: trabecular tissue density	0.4	0.5	1.0	-0.7	0.1	1.0	0.8	0.7	0.1	1.0	0.9
Water consumed over 24 hours	0.1	0.1	0.3	-0.1	-0.5	0.1	-0.0	-0.2	-0.1	0.4	0.3
Number of responses in last shaping day	1.8	1.8	4.2	-1.3	-2.0	1.2	1.2	1.2	1.6	1.0	0.8