Hub : Genes

Tbc1d12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Tbc1d12	0.04	0.03	2.3e-03	0.01	0.01	0	0.01	1.4e-02	1.1e-02	2.9e-01	1.9e-02
2	Liver	gene expression	Tbc1d12	0.03	0.02	2.7e-03	0.02	0.02	0.02	0.02	3.3e-03	4.5e-03	6.6e-03	4.5e-03
3	Brain	gene expression	Tbc1d12	0.06	0.04	2.3e-04	0.03	0.03	0.04	0.03	3.4e-04	5.2e-04	3.0e-04	5.0e-04
4	Brain	intron excision ratio	chr1_246092240_246094394	0.04	0.03	8.6e-03	0.02	0.01	0.01	0.01	7.9e-03	1.3e-02	1.2e-02	3.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.4	4.2	6.5	1.8	2.5	-2.5	1.0
Area under the delay curve	0.9	1.0	1.9	-1.4	-0.5	1.0	1.0
BMI with tail	0.3	1.0	1.8	1.3	0.7	-0.4	1.2
BMI without tail	0.1	0.2	0.4	0.4	-0.5	0.6	0.1
Body weight	0.1	0.6	1.2	1.1	0.1	-0.6	-0.8
Weight adjusted by age	0.1	0.1	0.3	0.2	-0.0	0.5	0.5
Bone surface	2.4	4.4	6.2	2.2	2.4	-2.5	1.0
Bone volume	2.4	4.4	6.5	2.2	2.4	-2.5	0.4
Breakpoint value in progressive ratio session	0.2	0.3	0.7	-0.9	-0.2	0.1	0.5
Number of licking bursts	0.9	1.5	3.1	-1.8	-0.9	1.3	0.4
Context. condit. distance diff. score	1.4	1.7	2.4	1.0	1.5	-1.6	1.0
Locomotion velocity, session 1	2.0	2.2	5.2	-2.3	-0.9	1.5	0.7
Locomotion distance, session 1	0.8	1.0	2.4	-1.5	-0.7	0.9	-0.1
Locomotion velocity, session 2	1.4	1.7	4.2	-0.6	1.1	-1.0	2.0
Locomotion distance, session 2	0.2	0.3	0.5	-0.7	0.3	-0.2	0.7
Locomotion velocity, session 3	0.3	0.4	0.9	0.3	0.7	-1.0	-0.0
Locomotion distance, session 3	0.8	0.9	1.4	0.6	0.6	-1.2	-1.2
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	-0.3	0.3	-0.1	0.1
Stereotopy head waving duration, day 3	0.3	0.3	0.8	-0.4	0.5	-0.1	0.9
Locomotion velocity, session 7	2.4	2.7	4.3	1.5	2.0	-2.1	0.0
Locomotion distance, session 7	2.1	2.6	4.2	1.8	1.8	-2.0	-0.0
Stereotopy head waving bouts, day 7	0.5	0.6	2.1	-1.5	-0.0	0.2	0.4
Stereotopy head waving duration, day 7	0.2	0.3	0.9	-1.0	0.2	0.0	0.3
Locomotion velocity, session 8	0.4	0.5	0.8	-0.0	0.8	-0.8	0.9
Locomotion distance, session 8	1.4	2.1	3.9	0.3	1.5	-1.5	2.0
Degree of sensitization distance	0.7	0.7	2.5	0.2	0.5	-0.2	1.6
Degree of sensitization stereotypy	0.7	0.8	2.8	-1.7	-0.4	0.5	-0.0
Conditioned locomotion	0.5	0.6	1.2	1.1	0.2	-0.3	-0.9
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.3	-0.3	0.4	0.3
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.5	-0.2	0.2	0.5
Cocaine response before conditioning	0.2	0.2	0.7	-0.8	-0.2	-0.1	0.4
Saline control response	1.8	2.3	4.0	-2.0	-1.5	1.6	-0.7
Bone: connectivity density	3.6	5.6	8.2	2.4	2.9	-2.6	1.3
Bone: cortical apparent density	0.6	0.8	1.7	-1.3	-0.5	1.0	0.5
Bone: cortical area	0.7	1.1	1.7	1.2	0.7	-1.3	-0.9
Bone: cortical porosity	1.3	1.4	2.7	0.3	1.3	-1.0	1.6
Bone: cortical porosity	1.2	1.3	1.8	0.5	1.3	-1.2	1.3
Bone: cortical thickness	1.0	1.6	2.0	-1.3	-1.4	1.0	-1.4
Bone: cortical thickness	1.9	2.3	4.4	-2.1	-1.5	1.5	-0.6
Bone: cortical tissue density	0.6	0.9	1.7	-1.3	-0.5	1.0	0.7
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	-0.4	0.1	-0.0	-0.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.2	-0.0	0.1	0.0
Condit. Reinf. active responses	0.1	0.1	0.2	-0.3	-0.1	0.1	-0.4
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.3	-0.1	0.3	-0.4
Incentive salience index mean	0.4	0.4	0.7	-0.8	-0.8	0.6	-0.3
Condit. Reinf. lever presses	1.3	1.8	3.3	-1.3	-1.8	1.5	-0.3
Condit. Reinf. active minus inactive responses	2.0	2.6	4.2	2.1	1.8	-1.7	0.1
Condit. Reinf. active-inactive response ratio	1.3	1.5	2.4	1.5	1.4	-1.2	0.6
Condit. Reinf. active responses	0.8	1.1	1.7	1.3	0.5	-0.9	-1.3
Condit. Reinf. inactive responses	1.5	2.0	5.3	-0.6	-1.3	0.7	-2.3
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.6	-0.6	0.3	-0.7
Condit. Reinf. lever reinforcers received	0.5	0.6	1.5	0.8	0.2	-0.6	-1.2
Conditioned reinforcement - actives	0.3	0.5	1.5	-0.6	0.3	-0.6	1.2
Conditioned reinforcement - inactives	0.9	1.3	1.9	-0.5	1.2	-1.4	1.3
Conditioned locomotion	0.1	0.1	0.4	-0.6	-0.3	0.2	0.1
Patch foraging indifference point 0 sec	0.5	0.8	1.2	-0.8	-1.1	0.7	-1.0
Patch foraging indifference point AUC	3.4	4.8	8.6	-2.9	-2.2	2.4	-0.3
Delay disc. indifference point, 0s delay	1.1	1.2	2.3	0.6	1.3	-0.8	1.5
Delay disc. indifference point, 16s delay	0.8	0.9	1.6	-1.3	-0.9	1.0	0.4
Delay disc. indifference point, 2s delay	0.3	0.3	1.0	-0.3	0.5	0.3	1.0
Delay disc. indifference point, 24s delay	1.7	1.9	3.8	-1.9	-1.3	1.3	0.6
Delay disc. indifference point, 4s delay	0.7	0.8	1.4	-1.1	-0.3	0.7	1.2
Delay disc. indifference point, 8s delay	2.3	2.6	4.8	-2.2	-1.4	1.9	0.4
Indifference point function ln k	2.9	5.1	8.4	2.9	2.4	-2.5	-0.1
Indifference point function log k	2.9	5.1	8.4	2.9	2.4	-2.5	-0.1
Patch foraging total patch changes 0 sec	0.5	0.9	1.5	-0.7	-1.1	0.7	-1.2
Patch foraging total patch changes 12 sec	4.2	5.5	8.6	-2.9	-2.5	2.5	-0.7
Patch foraging total patch changes 18 sec	0.8	1.3	2.8	-1.7	-1.0	1.2	0.1
Patch foraging total patch changes 24 sec	0.5	0.8	1.3	-1.1	-1.1	0.8	-0.4
Patch foraging total patch changes 6 sec	3.5	5.3	9.1	-3.0	-2.5	2.3	-0.6
Patch foraging time to switch 0 sec	0.7	1.5	1.9	-1.1	-1.1	1.4	1.3
Patch foraging water rate 0 sec	0.9	1.9	2.8	1.4	1.5	-1.7	-0.8
Patch foraging water rate 12 sec	0.5	0.9	1.3	0.9	1.0	-1.1	-0.9
Patch foraging water rate 18 sec	1.1	1.7	3.3	1.1	1.5	-1.8	-0.4
Patch foraging water rate 24 sec	0.6	0.8	1.2	1.0	1.0	-1.1	-0.2
Patch foraging water rate 6 sec	0.1	0.2	0.3	0.3	0.4	-0.4	-0.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.2	-0.7	0.2	-0.5
Distance traveled before self-admin	0.5	0.6	1.1	0.4	1.0	-0.9	0.7
Distance traveled after self-admin	1.3	1.6	3.0	1.0	1.7	-1.5	0.6
Extensor digitorum longus weight	0.2	1.0	1.6	1.1	1.3	-1.1	-0.0
Bone: elastic displacement	0.1	0.1	0.3	0.2	0.1	0.6	0.3
Bone: elastic work	0.3	0.4	0.7	0.5	0.8	-0.5	0.5
Bone: endosteal estimation	3.9	8.4	11.4	3.3	3.2	-3.4	0.9
Bone: endosteal perimeter	3.9	8.3	10.7	3.2	3.1	-3.3	1.5
Epididymis fat weight	0.6	2.0	5.4	2.3	1.1	-0.9	-0.9
Delta time in closed arm before/after self-admin	0.8	0.7	1.6	-0.2	-0.9	0.7	-1.3
Delta time in open arm before/after self-admin	2.6	2.6	6.3	0.6	1.4	-1.3	2.5
Diff in mean of infusions in LGA sessions	1.2	1.5	2.1	1.1	1.5	-1.4	0.9
Delay discount exponential model param	1.0	1.1	2.0	1.4	0.5	-1.0	-1.0
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.1	-0.3	-0.0	-0.1
Active lever presses in extinction session 6	4.7	4.6	9.2	1.0	2.3	-1.8	3.0
Bone: final force	0.1	0.2	0.4	0.2	-0.1	-0.6	-0.6
Bone: final moment	0.2	0.3	0.5	0.4	-0.1	-0.6	-0.7
Food consumed during 24 hour testing period	0.2	0.3	0.6	-0.8	-0.6	0.2	-0.5
Glucose	0.1	0.2	0.3	0.6	0.1	-0.4	-0.6
Heart weight	0.9	1.4	3.8	0.6	-1.0	0.7	-2.0
Delay discount hyperbolic model param	0.7	0.8	1.5	1.2	0.4	-0.9	-1.0
Intermittent access intake day 1-15 change	1.1	2.3	3.4	1.4	1.6	-1.8	1.1
Intermittent access intake escalation	1.7	3.5	5.2	1.7	2.0	-2.3	1.3
Intermittent access intake escalation 2	4.7	5.3	7.0	1.8	2.5	-2.6	2.2
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	0.3	0.6	-0.3	0.0
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.6	0.7	0.8	-0.8	-0.1
Intermitt. access escalation Index	0.5	0.7	0.8	0.9	0.9	-0.9	-0.7
Intermittent access day 1 total infusions	0.1	0.2	0.3	-0.1	0.6	-0.5	0.6
Intermittent access day 15 total infusions	1.5	2.2	4.0	1.5	1.5	-2.0	0.7
Intermittent access terminal intake (last 3 days)	1.6	2.0	3.4	1.0	1.6	-1.8	1.2
Intermittent access total infusions	0.6	0.7	1.1	0.5	0.9	-1.0	0.7
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.6	0.2	-0.4	0.4
Intermittent access day 15 total locomotion	0.2	0.4	1.1	-0.7	0.0	0.0	1.0
Intermittent access total locomotion	0.5	0.6	1.9	-0.2	0.5	-0.4	1.4
Intermittent access standard deviation	1.5	3.1	4.2	1.1	1.6	-2.1	2.1
Left kidney weight	0.1	0.6	1.1	-0.5	-1.0	0.5	-0.9
Right kidney weight	0.6	2.7	4.2	-1.2	-2.1	1.5	-1.7
Cocaine induced anxiety	1.2	1.7	2.3	1.4	1.5	-1.3	0.9
Post-drug Anxiety	0.7	0.7	1.7	1.1	0.0	0.2	-1.3
Baseline Anxiety	2.6	3.0	8.2	-0.1	-1.5	1.2	-2.9
Tail length	0.1	0.4	1.5	0.3	-0.2	-0.3	-1.2
Length with tail	0.1	0.6	2.1	-0.3	-0.4	-0.5	-1.5
Length without tail	0.2	0.6	1.9	0.2	0.7	-1.4	-0.2
Times rat made contact with spout	0.3	0.4	0.9	-0.1	1.0	-0.7	0.4
Lifetime Intake	0.3	0.3	0.4	0.4	0.7	-0.7	0.6
Liver weight, left	0.1	0.2	0.6	-0.1	-0.8	0.5	-0.4
Liver weight, right	0.4	0.6	1.3	0.9	0.7	-1.1	0.2
Locomotor activity	0.1	0.1	0.2	-0.0	0.3	-0.5	-0.4
Locomotor testing distance	0.1	0.1	0.2	-0.2	0.3	-0.5	-0.2
Locomotor testing rearing	0.6	1.1	1.6	0.8	1.2	-1.3	0.9
Locomotion in novel chamber	2.8	3.6	4.7	2.2	2.2	-2.0	1.0
Locomotion in novel chamber post-restriction	0.1	0.2	0.3	-0.5	-0.5	0.2	-0.3
Fecal boli incidents, locomotor time 1	0.8	1.1	1.9	0.2	1.4	-1.2	1.1
Change in fecal boli incidents, locomotor task	1.0	1.0	2.2	-0.5	-1.5	1.1	-0.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.7	-0.3	-0.2	-0.8	0.1
Bouts of movement, locomotor time 1	0.5	0.5	1.1	-1.0	-0.3	0.7	0.6
Total resting periods, locomotor time 1	0.7	0.8	2.1	-1.5	-0.4	0.7	0.7
Rest time, locomotor task time 1	0.2	0.3	0.6	-0.8	0.3	0.1	0.6
Distance moved, locomotor task time 1	0.6	0.9	2.5	0.5	-1.0	0.2	-1.6
Vertical activity count, locomotor time 1	0.3	0.6	1.7	0.3	-0.9	0.2	-1.3
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.6	-0.4	0.3	-0.8	0.4
Bouts of movement, locomotor time 2	1.6	2.6	5.4	-2.3	-1.0	1.5	1.3
Total resting periods, locomotor time 2	1.6	2.8	6.0	-2.4	-1.0	1.4	1.5
Rest time, locomotor task time 2	0.6	0.7	1.8	-1.3	-0.1	0.4	1.0
Distance moved, locomotor task time 2	0.9	1.1	2.1	1.3	0.2	-0.7	-1.5
Vertical activity count, locomotor time 2	0.1	0.2	0.4	0.6	-0.0	-0.4	-0.3
Light reinforcement 1	0.2	0.4	0.6	-0.7	-0.4	0.8	-0.5
Light reinforcement 2	1.0	1.5	3.1	-1.8	-0.8	1.5	0.4
Bone: marrow area	4.0	8.7	11.7	3.3	3.3	-3.4	1.0
Bone: maximum diameter	4.8	8.9	12.9	3.3	3.4	-3.6	0.7
Bone: maximum force	0.5	0.8	1.6	0.8	1.0	-1.3	0.3
Bone: maximum moment	0.5	0.9	1.5	1.0	0.9	-1.2	0.2
Mean time between licks in bursts	0.2	0.4	0.6	0.1	-0.8	0.5	-0.8
Mean num. licks in bursts	1.7	2.6	3.8	1.9	1.7	-1.9	0.1
Cd content in liver	1.2	1.3	2.1	-1.3	-1.1	1.4	-0.5
Co content in liver	2.3	2.6	7.2	-0.4	-1.3	1.2	-2.7
Cu content in liver	3.9	4.6	8.2	-2.9	-2.1	2.4	0.3
Fe content in liver	2.3	2.8	4.4	-1.9	-1.8	2.1	-0.2
K content in liver	1.4	1.3	4.5	-0.8	-0.1	0.1	2.1
Mg content in liver	1.4	1.5	5.0	-0.8	-0.1	0.2	2.2
Mn content in liver	3.0	3.3	5.1	-2.3	-1.1	1.5	2.2
Na content in liver	1.2	1.3	2.1	-1.4	-1.0	1.1	0.9
Rb content in liver	0.1	0.1	0.3	0.1	0.6	-0.4	0.2
Se content in liver	16.4	19.4	29.6	-5.4	-4.6	5.2	-0.0
Sr content in liver	0.4	0.3	0.6	-0.8	-0.6	0.6	-0.3
Zn content in liver	1.6	1.7	3.0	-1.7	-1.2	1.5	0.4
Bone: minimum diameter	5.6	10.2	16.2	4.0	3.3	-3.8	-0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.5	0.4	-0.1	-0.3
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.7	-0.4	0.1	0.1
Total zone transitions, hab. session 1	0.0	0.1	0.2	-0.4	0.2	-0.2	0.1
Total locomotion distance, hab. session 1	1.0	1.4	3.1	-1.8	-1.0	1.1	-0.2
Locomotion velocity, hab. session 1	2.0	2.8	5.2	-2.3	-1.6	1.6	-0.8
Time in familiar zone, hab. session 2	0.7	0.7	2.2	0.0	-0.5	0.7	-1.5
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	0.1	-0.3	0.3
Total zone transitions, hab. session 2	0.5	0.6	0.8	-0.9	-0.9	0.7	-0.5
Total locomotion distance, hab. session 2	1.0	1.3	1.6	-1.3	-1.2	1.2	-0.7
Locomotion velocity, hab. session 2	1.0	1.3	2.0	-1.4	-1.2	1.2	-0.6
Novel to familiar place preference ratio	4.8	5.2	9.9	0.8	2.5	-2.0	3.2
Novelty place preference	4.8	5.2	9.2	0.9	2.5	-2.1	3.0
Time in novel zone, NPP test	4.7	5.0	8.1	0.9	2.6	-2.2	2.8
Total zone transitions, NPP test	0.7	1.0	1.2	-1.0	-1.1	0.8	-1.0
Total locomotion distance, NPP test	1.9	2.6	4.8	-2.2	-1.6	1.5	-0.8
Locomotion velocity, NPP test	1.7	2.4	4.2	-2.1	-1.6	1.5	-0.7
Intraocular pressure	0.3	0.5	1.0	-0.5	-0.7	1.0	0.1
Delta distance traveled before/after self-admin	1.1	1.2	1.9	1.4	1.2	-1.2	0.3
Delta ambulatory time before/after self-admin	1.6	2.0	3.2	1.8	1.5	-1.6	0.2
Parametrial fat weight	0.8	1.8	3.4	-0.8	-1.4	1.0	-1.8
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.3	0.1	0.2	-0.6
Pavlov. Cond. magazine entry latency	0.7	1.0	1.3	-0.9	-1.1	0.7	-1.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.1
Pavlov. Cond. index score	0.4	0.5	0.9	-1.0	-0.8	0.5	-0.3
Pavlov. Cond. latency score	0.3	0.3	0.6	-0.8	-0.7	0.4	-0.3
Pavlov. Cond. lever contacts	0.3	0.4	0.7	-0.7	-0.8	0.5	0.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	0.2	0.6	-0.2	0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	-0.4	-0.2	0.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	-0.9	-0.8	0.5	-0.3
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.5	-0.7	0.3	-0.3
Pavlov. Cond. lever latency	1.1	1.5	1.8	1.3	1.2	-0.9	1.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	-0.6	-0.4	0.2	-0.6
Pavlov. Cond. change in total contacts	0.4	0.6	0.8	-0.6	-0.9	0.6	-0.9
Pavlov. Cond. index score	0.6	0.9	1.3	-1.2	-0.9	0.6	-1.0
Pavlov. Cond. latency score	0.5	0.7	1.1	-1.1	-0.7	0.5	-0.9
Pavlov. Cond. lever contacts	1.3	1.8	2.3	-1.3	-1.4	1.1	-1.5
Pavlov. Cond. magazine entry number	1.6	2.0	2.6	1.6	1.4	-1.1	1.4
Pavlov. Cond. intertrial magazine entries	0.8	1.2	1.7	1.3	1.2	-0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.3	-1.1	-0.8	0.5	-0.8
Pavlov. Cond. response bias	1.1	1.5	1.9	-1.3	-1.3	0.9	-1.4
Time in closed arm before self-admin	0.7	0.9	1.4	0.2	1.2	-0.9	1.2
Time in closed arm after self-admin	0.4	0.4	1.0	-0.1	-0.4	0.6	-1.0
Time in open arm before self-admin	0.4	0.5	1.1	0.3	-0.3	0.8	-1.1
Time in open arm after self-admin	0.5	0.5	1.8	-0.1	0.5	-0.3	1.4
Bone: periosteal estimation	2.6	5.4	8.1	2.7	2.5	-2.8	0.5
Bone: periosteal perimeter	2.7	4.6	6.6	2.5	2.3	-2.6	0.5
Bone: post-yield work	1.1	1.6	2.1	1.1	1.3	-1.4	1.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.8	-0.2	0.2	-0.2	0.9
Progressive ratio test 1 breakpoint	0.2	0.2	0.7	-0.4	0.0	-0.0	0.8
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.3	0.4	1.1	-0.9	0.3
Progressive ratio test 2 active lever presses	1.4	1.7	3.3	0.1	1.4	-1.2	1.8
Progressive ratio test 2 breakpoint	1.5	1.7	3.2	0.1	1.4	-1.3	1.8
Progressive ratio test 2 inactive lever presses	0.6	0.9	1.9	-0.0	1.1	-0.8	1.4
Incentive Sensitization - Responses	1.8	2.5	3.5	0.3	1.8	-1.8	1.9
Incentive Sensitization - Breakpoint	1.7	2.2	3.0	0.2	1.7	-1.7	1.7
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.3	-0.5	0.7	-0.3
Progressive ratio	0.4	0.7	1.7	0.2	-0.7	0.7	-1.3
Food seeking constrained by brief footshock	0.2	0.2	0.5	-0.7	-0.5	0.1	-0.2
Seeking ratio, punishment vs. effort	0.2	0.3	0.9	-0.9	-0.1	-0.1	0.7
Retroperitoneal fat weight	0.2	1.0	2.9	0.3	-0.7	0.7	-1.7
Reaction time number correct	1.9	3.7	5.5	1.9	2.3	-2.0	1.3
Reaction time mean minus median	0.2	0.5	1.2	0.7	0.2	-0.6	-1.1
Reaction time mean minus median AUC	0.2	0.5	1.1	0.7	0.2	-0.4	-1.0
Reaction time num false alarms	0.1	0.1	0.3	0.0	-0.5	0.2	-0.4
Reaction time num false alarms AUC	0.1	0.2	0.4	0.1	-0.6	0.2	-0.5
Reaction time trials correct on left	1.9	3.7	5.5	1.9	2.3	-2.0	1.3
Reaction time trials on left	1.9	3.5	5.3	1.9	2.3	-2.0	1.2
Reaction time mean	1.0	1.5	2.6	-0.7	-1.4	1.1	-1.6
Reaction time mean AUC	1.2	1.9	2.6	-0.9	-1.6	1.3	-1.6
Median of all reaction times	1.2	1.7	2.2	-1.0	-1.5	1.4	-1.4
Reaction time omissions	0.7	1.0	2.1	1.0	0.6	-0.6	-1.5
Reaction time false alarm rate	1.0	1.4	2.6	-0.8	-1.6	1.1	-1.0
Reaction time premature initiation rate	0.6	0.8	1.8	-0.7	-0.9	0.2	-1.3
Reaction time premature initiations	0.3	0.5	0.9	0.3	0.4	-0.8	-0.9
Std. dev. reaction times	0.7	1.3	4.4	0.3	-0.7	0.1	-2.1
Reaction time trials completed	1.9	3.5	5.3	1.9	2.3	-2.0	1.2
Reaction time trials AUC	1.7	3.3	5.1	1.8	2.2	-1.8	1.1
Run reversals in cocaine runway, females	0.6	0.6	1.1	-0.8	-0.4	0.7	1.1
Run reversals in cocaine runway, males	2.5	2.6	3.9	-2.0	-1.7	1.5	-1.1
Latency to leave start box in cocaine runway	2.1	2.4	5.1	2.3	1.5	-1.3	-0.7
Latency to leave start box in cocaine runway, F	2.9	3.4	6.4	2.5	2.0	-1.8	-0.0
Latency to leave start box in cocaine runway, M	0.3	0.2	0.5	0.7	0.2	0.1	-0.6
Std. dev. time between licks in bursts	1.7	2.3	3.9	-1.1	-1.9	2.0	-0.5
Total sessions with >9 infusions	0.4	0.4	0.9	-0.4	-0.8	1.0	-0.2
Short access day 1 total inactive lever presses	1.4	1.8	3.3	1.1	1.8	-1.1	1.2
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.2	0.4	-0.3	-0.4
Short access day 1 total infusions	0.6	0.8	1.3	-1.0	-0.7	1.1	0.4
Short access day 10 total infusions	0.9	1.2	1.6	-1.1	-1.2	1.3	-0.8
Short access total infusions	0.1	0.1	0.2	-0.3	0.0	0.1	0.4
Short access day 1 locomotion	0.2	0.3	0.8	0.2	0.0	0.5	0.9
Short access day 10 total locomotion	0.2	0.3	0.6	-0.7	-0.5	0.4	0.6
Short access total locomotion	0.2	0.2	0.5	-0.4	-0.4	0.7	0.4
One hour access (0.3 mA shock)	2.9	3.3	4.9	1.0	2.0	-2.2	1.8
Compulsive drug intake	1.5	1.7	2.6	1.5	1.4	-1.6	-0.0
One hour access (shock baseline)	0.1	0.2	0.6	-0.0	0.2	-0.4	0.8
Social response proportion	3.3	3.7	5.3	1.7	1.9	-1.7	2.3
Social responses	0.8	1.1	1.4	1.1	0.8	-1.1	1.2
Social time	0.4	0.5	1.4	-0.2	-0.7	0.2	1.2
Soleus weight	1.1	3.2	4.7	2.1	2.2	-1.9	0.5
Bone: stiffness	0.7	1.1	2.3	0.9	1.1	-1.5	-0.2
Tibialis anterior weight	0.6	2.2	3.4	1.4	1.9	-1.6	0.9
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.7	-0.9	-0.2	0.7	0.8
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.5	0.6	0.6	-0.7	0.3
Time to tail flick, test, before self-admin	0.9	0.9	1.3	0.6	0.9	-1.0	1.1
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.0	0.5	-0.0	0.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.8	1.5	0.9	1.0	-1.2	0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.6	-0.2	0.6	-0.2
Tibia length	0.1	0.3	0.5	-0.2	-0.6	0.5	-0.7
Ambulatory time before self-admin	0.3	0.4	1.0	0.4	1.0	-0.7	0.3
Ambulatory time after self-admin	3.1	3.7	6.1	1.5	2.5	-2.2	1.2
Bone: tissue strength	0.1	0.1	0.4	0.6	0.1	-0.3	-0.1
Total heroin consumption	0.1	0.1	0.2	-0.5	-0.1	0.0	0.4
Bone: trabecular number	1.6	2.6	3.9	1.4	2.0	-1.9	0.9
Bone: trabecular spacing	1.3	1.7	2.4	-0.8	-1.5	1.3	-1.4
Bone: trabecular thickness	1.9	2.3	3.7	1.6	1.8	-1.9	-0.1
Bone: trabecular tissue density	0.8	1.1	1.6	1.1	1.3	-1.2	0.3
Water consumed over 24 hours	0.6	0.8	1.2	-0.2	1.1	-1.0	1.1
Number of responses in last shaping day	0.3	0.3	0.5	-0.0	-0.5	0.7	-0.7