Hub : Genes

Tbc1d10a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative TSS NM_001015022.4 0.03 0.02 4.8e-04 0.03 0.02 0.02 0.02 4.2e-04 1.8e-03 3.9e-03 4.1e-03
2 PL alternative TSS XM_039092211.1 0.03 0.02 9.1e-04 0.02 0.02 0.01 0.02 2.4e-03 4.0e-03 8.4e-03 4.7e-03
3 OFC gene expression Tbc1d10a 0.21 0.11 1.5e-03 0.07 0.1 0.01 0.06 1.2e-02 2.6e-03 1.5e-01 1.4e-02
4 Liver alternative TSS NM_001015022.4 0.06 0.04 7.1e-04 0.03 0.02 0.02 0.02 3.8e-04 2.2e-03 1.4e-03 2.0e-03
5 Liver alternative TSS XM_039092211.1 0.06 0.04 4.1e-04 0.03 0.02 0.03 0.02 2.7e-04 1.5e-03 7.1e-04 1.3e-03
6 Liver mRNA stability Tbc1d10a 0.04 0.03 7.6e-03 0.02 0 0.01 0.01 8.9e-04 7.5e-02 8.0e-03 6.8e-03
7 NAcc intron excision ratio chr14_79074168_79078538 0.03 0.02 6.3e-03 0 0.01 -0 0.01 1.4e-01 1.0e-02 4.5e-01 6.5e-02
8 PL gene expression Tbc1d10a 0.08 0.04 5.1e-06 0.03 0.05 0.05 0.05 2.9e-04 4.7e-06 2.2e-06 2.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.71.23.10.9-0.91.20.9-0.90.4-1.81.3
Area under the delay curve7.78.111.7-3.13.1-3.4-3.33.3-2.62.3-0.1
BMI with tail0.41.46.7-1.01.0-2.6-0.50.50.11.4-0.4
BMI without tail0.20.41.5-0.20.2-1.20.0-0.00.20.21.2
Body weight1.24.911.1-2.42.4-3.3-2.22.2-1.81.80.5
Weight adjusted by age1.11.32.4-1.11.1-1.6-1.21.2-0.60.81.0
Bone surface0.10.20.4-0.60.6-0.5-0.50.5-0.6-0.00.5
Bone volume0.10.20.5-0.30.30.1-0.20.2-0.5-0.50.7
Breakpoint value in progressive ratio session0.20.20.7-0.30.3-0.5-0.50.5-0.90.4-0.5
Number of licking bursts1.31.63.0-1.21.2-0.8-1.71.7-1.50.40.7
Context. condit. distance diff. score2.53.15.41.9-1.91.42.0-2.02.3-1.3-0.1
Locomotion velocity, session 10.60.64.00.2-0.20.30.2-0.2-0.30.9-2.0
Locomotion distance, session 11.82.33.31.7-1.71.31.8-1.81.3-1.40.7
Locomotion velocity, session 20.81.04.90.3-0.31.30.4-0.4-0.60.4-2.2
Locomotion distance, session 21.72.34.01.6-1.61.72.0-2.01.1-0.8-0.8
Locomotion velocity, session 31.51.83.11.3-1.30.81.8-1.81.6-1.10.5
Locomotion distance, session 30.40.40.8-0.70.7-0.8-0.10.1-0.70.9-0.4
Stereotopy head waving bouts, day 31.41.72.41.5-1.51.51.5-1.50.7-1.20.1
Stereotopy head waving duration, day 32.32.84.12.0-2.01.71.9-1.91.6-1.2-0.2
Locomotion velocity, session 70.20.20.9-0.10.1-0.00.1-0.1-0.90.5-0.6
Locomotion distance, session 70.50.71.10.9-0.90.71.1-1.10.5-0.5-0.6
Stereotopy head waving bouts, day 70.10.10.4-0.10.1-0.50.1-0.10.6-0.10.1
Stereotopy head waving duration, day 70.20.20.8-0.40.4-0.9-0.40.40.20.10.6
Locomotion velocity, session 81.31.63.21.3-1.31.81.2-1.20.8-0.4-1.6
Locomotion distance, session 87.110.415.13.6-3.63.23.9-3.93.3-2.4-0.3
Degree of sensitization distance3.93.96.42.5-2.52.41.7-1.71.8-1.7-0.5
Degree of sensitization stereotypy0.40.51.2-0.80.8-1.1-0.70.7-0.10.40.5
Conditioned locomotion0.70.81.50.6-0.60.21.0-1.00.9-1.21.1
Cocaine response after cond. corrected0.50.61.1-1.01.0-0.8-0.80.8-0.80.20.4
Cocaine response after cond. not corrected0.91.01.8-1.31.3-1.2-0.60.6-1.10.20.7
Cocaine response before conditioning0.20.20.70.0-0.0-0.20.8-0.80.2-0.00.3
Saline control response0.91.22.11.1-1.10.81.5-1.51.0-0.0-0.8
Bone: connectivity density0.50.81.80.7-0.70.70.9-0.90.8-1.31.1
Bone: cortical apparent density0.20.20.7-0.10.1-0.4-0.80.8-0.20.10.2
Bone: cortical area2.33.56.3-2.12.1-2.5-1.81.8-1.61.90.2
Bone: cortical porosity0.30.31.1-0.60.6-0.30.2-0.2-0.4-0.41.1
Bone: cortical porosity0.20.20.8-0.30.3-0.10.7-0.70.1-0.40.9
Bone: cortical thickness1.52.45.1-1.71.7-2.2-1.51.5-1.11.21.0
Bone: cortical thickness0.70.82.80.5-0.5-0.30.8-0.80.7-0.91.7
Bone: cortical tissue density0.20.30.8-0.20.2-0.4-0.90.9-0.30.10.1
Condit. Reinf. active minus inactive responses0.40.51.9-0.20.2-0.4-0.50.5-0.50.9-1.4
Condit. Reinf. active-inactive response ratio0.91.06.20.1-0.10.2-0.20.20.11.2-2.5
Condit. Reinf. active responses0.10.10.70.1-0.1-0.1-0.00.0-0.20.5-0.9
Condit. Reinf. inactive responses0.10.21.00.1-0.1-0.20.1-0.1-0.4-0.31.0
Incentive salience index mean0.70.91.6-0.70.7-1.0-0.70.7-1.01.3-1.1
Condit. Reinf. lever presses0.40.51.5-0.70.7-1.2-0.10.1-0.81.0-0.1
Condit. Reinf. active minus inactive responses0.50.61.21.1-1.10.80.7-0.70.6-0.40.2
Condit. Reinf. active-inactive response ratio0.00.00.10.0-0.0-0.3-0.30.3-0.10.10.0
Condit. Reinf. active responses1.21.73.21.8-1.81.41.2-1.21.2-0.7-0.3
Condit. Reinf. inactive responses1.92.33.61.9-1.91.71.6-1.61.6-0.7-0.5
Condit. Reinf. lever presses0.40.50.91.0-1.00.50.7-0.70.9-0.30.3
Condit. Reinf. lever reinforcers received1.01.42.71.6-1.61.11.1-1.11.2-0.6-0.2
Conditioned reinforcement - actives1.41.42.7-1.51.5-1.7-0.70.7-0.31.2-1.1
Conditioned reinforcement - inactives2.22.53.9-2.02.0-1.8-1.61.6-1.01.5-0.6
Conditioned locomotion0.30.30.8-0.90.9-0.7-0.50.5-0.40.4-0.1
Patch foraging indifference point 0 sec0.20.41.0-0.20.2-0.2-0.90.9-1.00.20.3
Patch foraging indifference point AUC0.40.40.60.8-0.80.70.6-0.6-0.60.2-0.7
Delay disc. indifference point, 0s delay4.85.311.4-2.82.8-3.4-2.42.4-1.11.30.4
Delay disc. indifference point, 16s delay5.65.78.3-2.42.4-2.4-2.92.9-2.32.1-1.3
Delay disc. indifference point, 2s delay4.24.78.4-2.62.6-2.9-2.42.4-1.41.11.3
Delay disc. indifference point, 24s delay3.93.76.0-2.22.2-2.4-2.12.1-1.31.5-0.9
Delay disc. indifference point, 4s delay4.04.26.3-2.52.5-2.5-2.22.2-1.81.30.7
Delay disc. indifference point, 8s delay2.22.32.9-1.41.4-1.7-1.71.7-1.71.7-0.4
Indifference point function ln k0.20.31.30.1-0.10.40.4-0.40.3-1.01.1
Indifference point function log k0.20.31.30.1-0.10.40.4-0.40.3-1.01.1
Patch foraging total patch changes 0 sec0.30.51.4-0.40.4-0.4-0.90.9-1.20.50.0
Patch foraging total patch changes 12 sec0.10.10.6-0.00.0-0.4-0.10.1-0.80.3-0.2
Patch foraging total patch changes 18 sec1.01.22.7-0.70.7-0.8-1.01.0-1.31.6-1.4
Patch foraging total patch changes 24 sec1.31.63.11.8-1.81.01.1-1.11.6-0.3-0.7
Patch foraging total patch changes 6 sec0.20.31.0-0.10.1-0.1-0.70.7-1.00.7-0.5
Patch foraging time to switch 0 sec0.30.42.0-0.10.1-0.5-0.60.61.4-0.30.3
Patch foraging water rate 0 sec0.60.93.8-0.40.4-0.4-0.20.2-1.91.5-0.8
Patch foraging water rate 12 sec0.20.30.90.3-0.30.21.0-1.0-0.40.30.0
Patch foraging water rate 18 sec1.82.44.41.5-1.51.21.6-1.60.8-1.72.1
Patch foraging water rate 24 sec0.30.40.80.4-0.40.40.8-0.8-0.20.9-0.9
Patch foraging water rate 6 sec0.20.30.70.2-0.20.20.8-0.8-0.60.30.5
Seeking ratio, delayed vs. immediate footshock0.20.31.30.6-0.61.10.1-0.1-0.3-0.3-0.1
Distance traveled before self-admin0.40.41.40.4-0.40.6-0.30.3-0.7-0.61.2
Distance traveled after self-admin0.40.41.1-0.50.5-0.4-0.60.6-0.7-0.11.1
Extensor digitorum longus weight2.28.613.4-3.13.1-3.2-3.13.1-3.72.30.5
Bone: elastic displacement0.60.71.90.7-0.70.70.5-0.50.9-1.11.4
Bone: elastic work0.30.43.10.1-0.1-0.00.2-0.20.2-0.61.8
Bone: endosteal estimation0.00.00.1-0.10.10.1-0.00.0-0.40.20.1
Bone: endosteal perimeter0.51.11.5-1.21.2-1.0-1.11.1-1.11.1-0.2
Epididymis fat weight0.20.41.7-0.20.2-0.60.0-0.00.8-0.61.3
Delta time in closed arm before/after self-admin5.55.38.42.9-2.92.02.3-2.32.3-2.31.0
Delta time in open arm before/after self-admin7.06.89.2-2.92.9-2.3-3.03.0-2.62.5-1.1
Diff in mean of infusions in LGA sessions0.10.20.3-0.10.1-0.6-0.40.40.4-0.20.6
Delay discount exponential model param7.17.511.13.0-3.03.33.1-3.12.5-2.20.1
Extinction: sum of active levers before priming1.41.31.9-0.90.9-1.1-1.41.4-1.01.1-1.3
Active lever presses in extinction session 60.90.82.4-1.61.6-0.9-0.50.5-0.5-0.10.4
Bone: final force0.20.30.7-0.50.5-0.8-0.50.5-0.30.80.2
Bone: final moment0.20.30.5-0.60.6-0.7-0.60.6-0.50.60.4
Food consumed during 24 hour testing period0.91.12.8-0.30.30.1-0.90.9-1.41.4-1.7
Glucose17.326.138.2-4.94.9-3.8-4.94.9-5.36.2-5.6
Heart weight0.30.50.90.6-0.60.40.7-0.70.80.2-1.0
Delay discount hyperbolic model param7.37.711.83.1-3.13.43.1-3.12.4-2.2-0.0
Intermittent access intake day 1-15 change1.21.23.4-1.01.0-1.0-0.70.7-0.61.4-1.8
Intermittent access intake escalation0.80.83.1-0.70.7-0.8-0.50.5-0.31.1-1.8
Intermittent access intake escalation 20.30.21.4-0.00.00.2-0.00.0-0.50.6-1.2
Intermitt. access day 1 inactive lever presses0.60.61.80.6-0.60.51.0-1.01.3-0.20.2
Intermitt. access day 15 inactive lever presses1.31.44.5-0.90.9-1.1-0.80.8-0.72.1-1.5
Intermitt. access escalation Index0.20.10.20.5-0.5-0.10.3-0.30.20.4-0.5
Intermittent access day 1 total infusions0.40.51.0-1.01.0-1.0-0.50.5-0.20.40.6
Intermittent access day 15 total infusions1.61.72.8-1.71.7-1.7-1.11.1-0.81.4-0.7
Intermittent access terminal intake (last 3 days)0.50.61.0-0.90.9-0.9-0.50.5-0.41.0-0.6
Intermittent access total infusions0.60.61.2-1.11.1-0.9-0.60.6-0.60.7-0.1
Intermittent access day 1 locomotion0.60.71.00.7-0.70.91.0-1.00.9-0.80.3
Intermittent access day 15 total locomotion2.22.44.8-1.71.7-2.2-1.51.5-0.81.6-0.9
Intermittent access total locomotion0.60.71.1-0.90.9-1.0-0.80.8-0.60.9-0.7
Intermittent access standard deviation0.40.41.00.3-0.30.60.9-0.91.0-0.1-0.0
Left kidney weight0.51.42.41.0-1.00.90.9-0.91.5-1.41.5
Right kidney weight1.23.36.11.4-1.40.91.4-1.42.4-2.52.5
Cocaine induced anxiety1.21.43.6-0.90.9-0.5-0.80.8-1.91.4-1.4
Post-drug Anxiety0.60.71.3-0.80.8-0.5-0.40.4-1.11.1-1.1
Baseline Anxiety0.50.51.0-0.80.8-1.0-0.90.90.10.5-0.3
Tail length0.51.46.1-0.80.8-0.4-0.70.7-1.6-0.42.5
Length with tail0.62.44.1-1.61.6-1.2-1.81.8-2.00.61.2
Length without tail1.12.43.0-1.61.6-1.4-1.71.7-1.51.5-1.0
Times rat made contact with spout0.91.14.9-0.20.20.5-0.60.6-0.81.3-2.2
Lifetime Intake0.50.61.2-1.11.1-0.8-0.70.7-0.60.50.2
Liver weight, left4.67.312.12.7-2.72.72.2-2.22.8-3.52.7
Liver weight, right4.37.110.72.7-2.72.22.8-2.83.3-2.82.0
Locomotor activity0.60.93.4-0.90.9-0.1-0.10.1-1.81.2-1.0
Locomotor testing distance0.30.51.6-0.60.6-0.40.4-0.4-1.3-0.01.2
Locomotor testing rearing1.52.33.8-1.81.8-1.3-1.41.4-1.91.5-0.4
Locomotion in novel chamber0.91.12.70.6-0.60.31.2-1.21.6-1.11.1
Locomotion in novel chamber post-restriction1.01.32.41.3-1.31.01.0-1.01.6-0.4-1.2
Fecal boli incidents, locomotor time 10.40.41.10.8-0.81.10.5-0.5-0.0-0.5-0.3
Change in fecal boli incidents, locomotor task0.30.31.20.3-0.30.80.4-0.40.40.2-1.1
Time >=10cm from walls, locomotor time 10.30.31.60.3-0.3-0.5-0.20.21.3-0.2-0.2
Bouts of movement, locomotor time 10.70.82.0-0.80.8-0.7-1.01.00.10.8-1.4
Total resting periods, locomotor time 11.01.12.8-0.90.9-0.9-1.11.10.31.2-1.7
Rest time, locomotor task time 10.20.21.1-0.40.40.10.1-0.10.10.6-1.1
Distance moved, locomotor task time 10.30.31.30.2-0.20.2-0.30.3-0.7-0.61.1
Vertical activity count, locomotor time 10.20.20.50.3-0.30.6-0.30.3-0.4-0.70.7
Time >=10cm from walls, locomotor time 20.30.30.70.7-0.70.40.6-0.60.8-0.3-0.5
Bouts of movement, locomotor time 20.20.20.6-0.10.1-0.60.6-0.60.8-0.10.3
Total resting periods, locomotor time 20.20.20.6-0.10.1-0.70.4-0.40.60.20.0
Rest time, locomotor task time 20.10.20.40.4-0.40.60.4-0.40.4-0.1-0.4
Distance moved, locomotor task time 20.00.00.00.1-0.10.10.0-0.00.0-0.2-0.1
Vertical activity count, locomotor time 20.00.00.2-0.10.10.0-0.00.0-0.2-0.40.0
Light reinforcement 10.10.20.8-0.20.2-0.9-0.10.1-0.40.40.6
Light reinforcement 20.20.31.70.5-0.5-0.00.0-0.0-0.3-0.21.3
Bone: marrow area0.00.00.1-0.10.10.10.0-0.0-0.30.20.0
Bone: maximum diameter3.97.210.2-2.72.7-2.9-2.72.7-2.73.2-1.4
Bone: maximum force0.10.20.3-0.30.3-0.5-0.50.5-0.30.50.6
Bone: maximum moment0.20.30.7-0.40.4-0.3-0.60.6-0.50.30.8
Mean time between licks in bursts0.50.73.70.4-0.41.10.1-0.1-0.60.6-1.9
Mean num. licks in bursts1.21.44.81.0-1.01.11.0-1.01.00.5-2.2
Cd content in liver0.70.81.51.2-1.20.90.6-0.60.8-0.90.4
Co content in liver0.10.10.4-0.30.3-0.60.1-0.1-0.30.10.1
Cu content in liver0.10.10.2-0.10.1-0.2-0.50.5-0.2-0.2-0.1
Fe content in liver0.70.94.30.6-0.61.20.5-0.50.20.4-2.1
K content in liver0.60.61.2-0.90.9-1.0-0.70.7-0.5-0.31.1
Mg content in liver1.41.42.9-1.51.5-1.7-1.01.0-1.10.9-0.1
Mn content in liver0.30.31.6-0.20.20.00.3-0.3-0.3-0.81.2
Na content in liver5.96.28.1-2.82.8-2.4-2.62.6-2.42.5-1.4
Rb content in liver1.11.42.4-1.11.1-1.2-1.51.5-1.50.60.3
Se content in liver1.31.52.2-1.51.5-1.2-1.51.5-1.20.9-0.0
Sr content in liver1.51.42.8-0.90.9-0.7-1.31.3-1.11.7-1.2
Zn content in liver0.20.21.3-0.10.10.2-0.10.1-1.10.40.0
Bone: minimum diameter0.10.10.30.2-0.20.10.5-0.50.2-0.10.6
Time in familiar zone, hab. session 10.40.41.00.8-0.81.00.0-0.00.9-0.60.2
Time in novel zone, hab. session 10.30.30.8-0.60.6-0.5-0.30.3-0.90.10.6
Total zone transitions, hab. session 10.20.30.80.6-0.60.90.5-0.50.2-0.2-0.3
Total locomotion distance, hab. session 10.00.00.20.0-0.00.40.2-0.2-0.1-0.1-0.2
Locomotion velocity, hab. session 10.10.20.60.2-0.20.30.5-0.50.20.1-0.7
Time in familiar zone, hab. session 22.62.76.12.0-2.01.71.1-1.12.5-1.60.0
Time in novel zone, hab. session 22.52.56.5-1.71.7-1.5-1.21.2-2.51.8-0.0
Total zone transitions, hab. session 20.20.31.3-0.20.2-0.30.1-0.1-1.10.8-0.5
Total locomotion distance, hab. session 20.60.81.9-0.70.7-0.5-0.50.5-1.41.4-1.1
Locomotion velocity, hab. session 20.81.02.5-0.90.9-0.8-0.60.6-1.61.4-1.0
Novel to familiar place preference ratio1.91.92.8-1.51.5-1.5-1.01.0-1.51.7-1.4
Novelty place preference1.81.82.7-1.41.4-1.4-1.01.0-1.51.6-1.4
Time in novel zone, NPP test1.61.62.5-1.31.3-1.2-0.90.9-1.41.6-1.4
Total zone transitions, NPP test0.40.50.90.7-0.70.30.9-0.90.4-0.80.8
Total locomotion distance, NPP test0.00.10.20.1-0.1-0.10.4-0.40.0-0.30.2
Locomotion velocity, NPP test0.00.10.1-0.20.2-0.40.2-0.2-0.2-0.20.2
Intraocular pressure0.50.72.5-0.40.4-0.3-0.40.4-0.71.4-1.6
Delta distance traveled before/after self-admin0.50.51.1-1.11.1-1.0-0.30.30.40.5-0.3
Delta ambulatory time before/after self-admin0.10.10.6-0.40.4-0.30.2-0.20.8-0.2-0.1
Parametrial fat weight1.63.14.7-1.71.7-1.6-1.71.7-1.52.2-1.9
Pavlov. Cond. lever latency0.50.61.3-0.80.8-0.2-1.11.1-0.50.6-0.8
Pavlov. Cond. magazine entry latency1.01.32.11.2-1.21.21.5-1.50.8-0.80.4
Pavlov. Cond. change in total contacts0.70.82.4-0.90.9-0.8-0.40.4-1.61.0-0.3
Pavlov. Cond. index score1.21.62.91.3-1.31.01.7-1.71.0-1.00.5
Pavlov. Cond. latency score1.21.52.71.3-1.30.91.6-1.61.0-0.90.6
Pavlov. Cond. lever contacts0.60.71.60.9-0.90.41.3-1.30.5-0.40.3
Pavlov. Cond. magazine entry number1.21.43.1-1.21.2-1.1-1.81.8-0.70.60.0
Pavlov. Cond. intertrial magazine entries0.30.42.0-0.10.1-0.4-0.20.2-0.1-0.81.4
Pavlov. Cond. lever-magazine prob. diff.1.41.83.31.4-1.41.01.8-1.81.1-1.00.5
Pavlov. Cond. response bias0.40.51.40.5-0.50.31.2-1.20.2-0.40.2
Pavlov. Cond. lever latency1.52.02.5-1.61.6-1.3-1.61.6-1.50.21.2
Pavlov. Cond. magazine entry latency0.10.10.3-0.30.3-0.2-0.40.4-0.00.10.6
Pavlov. Cond. change in total contacts0.30.40.80.9-0.90.80.2-0.20.8-0.1-0.3
Pavlov. Cond. index score0.60.71.21.0-1.00.80.9-0.91.1-0.2-0.3
Pavlov. Cond. latency score0.60.71.21.1-1.10.90.9-0.91.1-0.4-0.1
Pavlov. Cond. lever contacts1.72.32.91.7-1.71.51.7-1.71.6-0.4-1.1
Pavlov. Cond. magazine entry number0.10.10.40.2-0.20.10.6-0.6-0.0-0.50.2
Pavlov. Cond. intertrial magazine entries0.20.20.40.4-0.40.20.6-0.6-0.1-0.3-0.4
Pavlov. Cond. lever-magazine prob. diff.0.60.71.21.0-1.00.90.8-0.81.1-0.4-0.1
Pavlov. Cond. response bias0.60.81.01.0-1.00.91.0-1.00.9-0.0-1.0
Time in closed arm before self-admin0.10.10.20.4-0.40.40.5-0.5-0.1-0.30.5
Time in closed arm after self-admin4.34.47.02.6-2.61.92.2-2.21.8-2.11.0
Time in open arm before self-admin0.20.20.40.3-0.30.10.6-0.60.6-0.3-0.0
Time in open arm after self-admin2.02.23.5-1.51.5-1.3-1.51.5-0.91.9-1.6
Bone: periosteal estimation0.61.21.8-1.21.2-1.4-1.01.0-1.21.30.2
Bone: periosteal perimeter1.93.25.5-2.12.1-2.3-1.71.7-1.51.90.0
Bone: post-yield work0.20.30.7-0.40.40.3-0.80.8-0.90.1-0.0
Progressive ratio test 1 active lever presses1.31.32.2-1.51.5-1.3-1.11.1-0.91.0-0.3
Progressive ratio test 1 breakpoint0.80.81.6-1.31.3-1.2-0.80.8-0.40.7-0.1
Progressive ratio test 1 inactive lever presses2.73.03.8-2.02.0-1.7-1.91.9-1.91.50.1
Progressive ratio test 2 active lever presses1.21.32.6-1.61.6-1.1-1.01.0-0.90.9-0.5
Progressive ratio test 2 breakpoint1.21.32.5-1.61.6-1.1-1.01.0-1.01.1-0.7
Progressive ratio test 2 inactive lever presses3.94.56.8-2.42.4-2.5-2.02.0-1.42.6-1.4
Incentive Sensitization - Responses1.01.01.9-1.41.4-1.0-0.80.8-0.71.0-0.6
Incentive Sensitization - Breakpoint1.01.01.9-1.41.4-1.0-0.80.8-0.71.0-0.6
Sum of active levers in priming session hrs 5-60.90.81.9-1.41.4-1.2-0.70.7-0.10.6-0.3
Progressive ratio0.40.41.3-0.30.3-0.2-1.11.1-0.30.00.8
Food seeking constrained by brief footshock2.22.84.1-2.02.0-1.7-1.61.6-1.60.51.8
Seeking ratio, punishment vs. effort0.30.40.8-0.90.9-0.90.2-0.2-0.70.40.2
Retroperitoneal fat weight0.10.20.6-0.20.2-0.80.0-0.00.40.7-0.8
Reaction time number correct0.30.41.00.5-0.51.00.7-0.7-0.30.5-0.9
Reaction time mean minus median0.10.21.2-0.20.20.00.1-0.10.20.4-1.1
Reaction time mean minus median AUC0.10.20.5-0.50.5-0.7-0.20.20.10.5-0.4
Reaction time num false alarms0.40.62.1-0.80.8-1.5-0.40.4-0.30.20.8
Reaction time num false alarms AUC0.40.61.9-0.80.8-1.4-0.40.4-0.1-0.01.3
Reaction time trials correct on left0.30.41.00.5-0.51.00.7-0.7-0.30.5-0.9
Reaction time trials on left0.30.51.10.5-0.51.00.8-0.8-0.20.5-0.9
Reaction time mean0.10.10.40.0-0.00.10.2-0.20.6-0.3-0.4
Reaction time mean AUC0.10.20.70.2-0.20.20.4-0.40.8-0.5-0.1
Median of all reaction times0.10.10.50.2-0.20.10.2-0.20.7-0.6-0.1
Reaction time omissions0.40.51.60.3-0.30.31.0-1.01.3-0.40.1
Reaction time false alarm rate0.81.13.1-1.01.0-1.8-0.60.60.1-0.31.7
Reaction time premature initiation rate4.35.88.32.7-2.71.92.9-2.92.4-2.11.3
Reaction time premature initiations3.04.37.12.3-2.32.02.7-2.71.7-1.40.6
Std. dev. reaction times0.20.21.1-0.40.4-0.30.0-0.00.20.5-1.0
Reaction time trials completed0.30.51.10.5-0.51.00.8-0.8-0.20.5-0.9
Reaction time trials AUC0.30.41.00.4-0.41.00.7-0.7-0.50.5-0.8
Run reversals in cocaine runway, females0.20.21.10.2-0.2-0.0-0.30.31.0-0.30.0
Run reversals in cocaine runway, males0.00.00.00.2-0.2-0.2-0.20.20.00.2-0.1
Latency to leave start box in cocaine runway0.10.20.3-0.40.4-0.5-0.40.40.2-0.10.6
Latency to leave start box in cocaine runway, F0.30.31.0-0.50.5-0.8-0.30.30.60.21.0
Latency to leave start box in cocaine runway, M0.10.10.6-0.00.00.5-0.10.1-0.8-0.4-0.4
Std. dev. time between licks in bursts0.60.71.61.0-1.01.31.0-1.00.1-0.6-0.2
Total sessions with >9 infusions0.10.10.30.1-0.10.10.6-0.60.4-0.30.4
Short access day 1 total inactive lever presses1.61.84.2-1.21.2-0.9-1.61.6-2.00.90.7
Short access day 10 total inactive lever presses0.80.91.41.1-1.10.91.2-1.20.8-0.60.7
Short access day 1 total infusions0.20.31.7-0.10.1-0.20.1-0.10.3-0.51.3
Short access day 10 total infusions0.20.20.70.1-0.10.40.5-0.50.3-0.50.8
Short access total infusions0.20.31.7-0.20.20.10.2-0.20.2-0.61.3
Short access day 1 locomotion2.12.23.21.6-1.61.41.4-1.41.3-1.61.8
Short access day 10 total locomotion1.82.04.31.4-1.42.11.4-1.41.0-1.60.6
Short access total locomotion4.74.96.62.2-2.22.62.5-2.51.8-2.21.4
One hour access (0.3 mA shock)0.40.50.7-0.80.8-0.6-0.80.8-0.60.5-0.5
Compulsive drug intake5.45.57.32.5-2.52.22.5-2.52.7-2.30.4
One hour access (shock baseline)4.14.77.0-2.62.6-2.0-2.22.2-2.31.9-0.9
Social response proportion1.11.24.0-0.40.40.1-0.90.9-1.41.4-2.0
Social responses1.11.44.0-0.60.6-0.2-0.80.8-1.61.6-2.0
Social time0.30.41.50.5-0.50.90.2-0.20.5-0.0-1.2
Soleus weight0.51.42.7-1.11.1-0.8-1.11.1-1.50.41.6
Bone: stiffness0.10.10.20.3-0.3-0.30.5-0.50.40.1-0.1
Tibialis anterior weight1.44.96.3-2.52.5-2.3-2.42.4-2.42.0-0.2
Time to tail flick, vehicle, before self-admin0.30.30.8-0.90.9-0.7-0.20.20.30.20.5
Time to tail flick, vehicle, after self-admin0.20.30.9-0.10.10.20.4-0.40.9-0.50.8
Time to tail flick, test, before self-admin1.51.54.00.9-0.91.02.0-2.01.0-0.5-0.0
Time to tail flick, test, after self-admin1.11.13.8-1.11.1-0.6-0.60.6-1.90.90.7
Delta time to tail flick, vehicle, before/after SA0.20.20.30.5-0.50.50.1-0.10.5-0.50.0
Delta time to tail flick, test, before/after SA1.61.42.8-1.01.0-0.9-1.51.5-1.71.0-0.0
Tibia length0.41.14.50.6-0.60.30.6-0.61.0-1.42.1
Ambulatory time before self-admin0.60.62.50.4-0.40.7-0.40.4-0.7-0.91.6
Ambulatory time after self-admin0.30.31.0-0.10.10.0-0.60.6-0.6-0.61.0
Bone: tissue strength0.10.10.70.4-0.40.9-0.00.0-0.10.1-0.0
Total heroin consumption0.00.00.10.3-0.30.20.1-0.1-0.1-0.30.0
Bone: trabecular number0.50.82.20.5-0.50.60.6-0.60.2-1.51.5
Bone: trabecular spacing1.62.03.5-1.21.2-1.0-1.81.8-0.91.9-1.2
Bone: trabecular thickness2.73.26.01.5-1.51.52.0-2.01.1-2.51.8
Bone: trabecular tissue density0.10.21.10.2-0.20.20.1-0.10.30.3-1.1
Water consumed over 24 hours0.60.72.20.2-0.21.1-0.70.7-1.00.7-1.5
Number of responses in last shaping day0.30.30.60.8-0.80.10.3-0.30.8-0.40.5