Tbc1d10a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	isoform ratio	XM_039092211.2	0.13	0.09	8.8e-03	0.06	0.07	0.07	0.03	8.5e-03	6.5e-03	6.8e-03	4.7e-02
2	RMTg	isoform ratio	NM_001015022.4	0.14	0.09	6.8e-03	0.07	0.07	0.07	0.04	6.0e-03	5.3e-03	5.0e-03	3.0e-02
3	IC	gene expression	Tbc1d10a	0.08	0.05	1.5e-03	0.08	0.04	0.05	0.05	3.7e-04	6.2e-03	4.7e-03	3.0e-03
4	OFC	gene expression	Tbc1d10a	0.2	0.11	2.5e-03	0.05	0.08	-0.01	0.04	2.6e-02	6.7e-03	6.3e-01	3.9e-02
5	PL	gene expression	Tbc1d10a	0.07	0.04	5.3e-06	0.03	0.05	0.05	0.06	5.3e-04	2.9e-06	1.5e-06	8.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.7	1.2	2.3	-0.7	0.7	0.9	1.4	1.5
Area under the delay curve	8.1	9.5	12.2	3.4	-3.4	-3.2	-3.5	-1.3
BMI with tail	0.7	2.5	6.4	1.5	-1.1	-0.9	-2.5	-1.3
BMI without tail	0.4	1.2	2.4	1.3	-1.1	-0.7	-1.5	0.3
Body weight	2.7	11.8	19.1	4.1	-3.7	-2.9	-4.4	-1.0
Weight adjusted by age	1.6	2.4	4.3	1.9	-2.1	-1.2	-1.6	0.3
Bone surface	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.2	0.4
Bone volume	0.1	0.1	0.5	0.1	-0.0	0.0	0.3	0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.4	-0.4
Number of licking bursts	0.6	1.0	1.9	1.4	-1.0	-1.2	-0.8	0.0
Context. condit. distance diff. score	2.1	2.6	3.5	-1.9	1.9	1.8	1.5	0.6
Locomotion velocity, session 1	1.0	1.0	2.3	-1.2	1.1	0.2	0.5	-1.5
Locomotion distance, session 1	1.4	1.7	2.5	-1.3	1.0	1.6	1.3	1.4
Locomotion velocity, session 2	1.9	2.2	2.9	-1.7	1.6	0.5	1.6	-1.6
Locomotion distance, session 2	2.5	3.4	6.3	-2.5	2.1	1.8	1.8	0.0
Locomotion velocity, session 3	1.3	1.4	3.7	-1.0	1.1	1.9	0.8	0.7
Locomotion distance, session 3	0.3	0.3	0.5	0.5	-0.3	-0.0	-0.7	-0.7
Stereotopy head waving bouts, day 3	1.9	2.2	3.3	-1.5	1.7	1.8	1.5	0.6
Stereotopy head waving duration, day 3	3.1	3.7	5.9	-2.1	2.4	2.3	1.7	0.5
Locomotion velocity, session 7	0.0	0.0	0.2	-0.0	-0.0	0.0	0.0	-0.5
Locomotion distance, session 7	0.6	0.8	1.3	-1.1	1.1	1.0	0.7	-0.3
Stereotopy head waving bouts, day 7	0.3	0.3	0.8	0.7	-0.6	-0.2	-0.9	-0.2
Stereotopy head waving duration, day 7	0.3	0.3	0.7	0.8	-0.6	-0.2	-0.8	0.2
Locomotion velocity, session 8	2.8	3.3	5.9	-2.4	2.3	0.9	1.9	-0.9
Locomotion distance, session 8	7.4	10.8	15.5	-3.9	3.7	3.5	3.3	1.1
Degree of sensitization distance	4.2	4.3	6.8	-2.6	2.5	1.6	2.4	0.5
Degree of sensitization stereotypy	0.7	0.8	1.3	1.1	-1.0	-0.7	-1.1	0.0
Conditioned locomotion	0.5	0.5	1.5	-0.3	0.2	1.1	0.2	1.2
Cocaine response after cond. corrected	0.8	0.9	1.6	1.2	-1.3	-0.9	-0.9	-0.1
Cocaine response after cond. not corrected	1.8	2.1	4.0	2.0	-1.9	-1.0	-1.4	0.2
Cocaine response before conditioning	0.2	0.2	0.3	0.6	-0.4	0.4	-0.3	0.4
Saline control response	0.7	1.0	1.7	-1.3	1.1	1.2	0.9	-0.0
Bone: connectivity density	0.5	0.8	1.9	-0.5	0.4	1.0	0.9	1.4
Bone: cortical apparent density	0.3	0.4	1.0	0.3	-0.7	-1.0	-0.6	-0.1
Bone: cortical area	2.8	4.3	6.7	2.6	-2.3	-1.7	-2.5	0.0
Bone: cortical porosity	0.3	0.3	0.6	0.7	-0.8	0.5	-0.2	0.5
Bone: cortical porosity	0.3	0.3	0.6	0.5	-0.5	0.8	-0.1	0.8
Bone: cortical thickness	2.5	4.1	6.5	2.5	-2.4	-1.4	-2.3	0.7
Bone: cortical thickness	0.9	1.0	4.0	0.1	-0.3	1.0	-0.1	2.0
Bone: cortical tissue density	0.4	0.5	1.2	0.4	-0.7	-1.1	-0.7	-0.3
Condit. Reinf. active minus inactive responses	0.3	0.3	1.1	-0.4	0.3	-0.2	-0.3	-1.0
Condit. Reinf. active-inactive response ratio	1.5	1.6	3.7	-1.5	1.5	0.1	0.3	-1.9
Condit. Reinf. active responses	0.1	0.2	0.4	-0.5	0.6	0.2	-0.1	-0.5
Condit. Reinf. inactive responses	0.2	0.3	0.8	0.7	-0.3	0.0	-0.3	0.9
Incentive salience index mean	0.4	0.5	0.9	0.4	-0.4	-0.6	-1.0	-0.9
Condit. Reinf. lever presses	0.5	0.7	1.8	1.0	-0.8	-0.2	-1.3	-0.1
Condit. Reinf. active minus inactive responses	0.7	0.9	1.3	-0.9	1.1	1.0	1.0	0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.1	0.3	-0.0	-0.1	-0.0
Condit. Reinf. active responses	1.6	2.2	3.3	-1.8	1.6	1.5	1.7	0.4
Condit. Reinf. inactive responses	2.1	2.7	4.1	-2.0	1.8	1.7	1.8	0.3
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.7	0.6	0.9	0.5	0.5
Condit. Reinf. lever reinforcers received	1.1	1.6	2.4	-1.6	1.3	1.3	1.3	0.5
Conditioned reinforcement - actives	1.1	2.0	2.7	1.5	-1.3	-1.3	-1.7	-1.1
Conditioned reinforcement - inactives	3.0	4.4	5.7	2.2	-2.3	-2.4	-2.2	-1.3
Conditioned locomotion	1.4	1.9	2.8	1.7	-1.3	-1.7	-1.3	-0.6
Patch foraging indifference point 0 sec	0.2	0.4	1.0	0.5	-0.9	-1.0	-0.3	0.1
Patch foraging indifference point AUC	0.4	0.6	1.0	-0.8	1.0	0.6	0.8	-0.5
Delay disc. indifference point, 0s delay	6.3	6.9	11.2	2.9	-3.0	-2.4	-3.3	-0.3
Delay disc. indifference point, 16s delay	5.1	5.6	8.5	2.1	-2.4	-2.9	-2.4	-2.0
Delay disc. indifference point, 2s delay	6.6	7.4	11.2	3.3	-3.3	-2.4	-3.0	0.3
Delay disc. indifference point, 24s delay	3.9	4.4	6.4	2.1	-2.2	-2.1	-2.5	-1.4
Delay disc. indifference point, 4s delay	4.7	4.9	7.5	2.7	-2.7	-2.1	-2.3	-0.1
Delay disc. indifference point, 8s delay	1.9	2.2	2.9	1.5	-1.4	-1.7	-1.7	-0.9
Indifference point function ln k	0.2	0.4	1.3	0.2	-0.4	0.4	0.4	1.2
Indifference point function log k	0.2	0.4	1.3	0.2	-0.4	0.4	0.4	1.2
Patch foraging total patch changes 0 sec	0.2	0.4	1.0	0.5	-0.8	-1.0	-0.3	-0.1
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.4	-0.1	-0.2	-0.4	-0.1
Patch foraging total patch changes 18 sec	0.5	0.7	2.1	0.2	-0.0	-1.1	-0.6	-1.4
Patch foraging total patch changes 24 sec	1.2	2.1	4.2	-2.0	1.8	1.4	1.1	0.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	0.3	-0.5	-0.8	-0.0	-0.3
Patch foraging time to switch 0 sec	0.1	0.1	0.4	0.0	0.2	-0.3	-0.6	0.4
Patch foraging water rate 0 sec	0.2	0.4	0.8	0.8	-0.6	-0.4	-0.4	-0.9
Patch foraging water rate 12 sec	0.1	0.2	1.0	-0.0	0.2	1.0	0.3	0.3
Patch foraging water rate 18 sec	1.2	1.8	5.8	-0.2	0.0	1.4	1.2	2.4
Patch foraging water rate 24 sec	0.2	0.3	0.5	-0.4	0.6	0.7	0.5	-0.4
Patch foraging water rate 6 sec	0.1	0.2	0.4	0.3	-0.2	0.6	0.3	0.6
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	1.4	-0.6	0.0	0.0	1.2	0.0
Distance traveled before self-admin	0.2	0.3	0.8	0.1	-0.6	-0.2	0.6	0.9
Distance traveled after self-admin	0.6	0.7	1.9	0.7	-1.1	-0.3	-0.0	1.4
Extensor digitorum longus weight	2.6	10.3	16.4	4.0	-3.9	-3.0	-3.3	-0.3
Bone: elastic displacement	0.3	0.3	1.3	0.0	0.0	0.1	0.5	1.1
Bone: elastic work	0.6	0.8	2.4	1.0	-0.7	-0.2	-0.2	1.6
Bone: endosteal estimation	0.0	0.0	0.1	0.0	0.0	-0.1	0.3	-0.1
Bone: endosteal perimeter	0.4	0.9	1.4	1.1	-1.0	-1.2	-0.8	-0.4
Epididymis fat weight	0.9	3.2	5.3	2.2	-2.0	-1.4	-2.3	-0.2
Delta time in closed arm before/after self-admin	3.8	3.6	6.3	-1.9	1.7	2.5	1.7	1.4
Delta time in open arm before/after self-admin	6.5	6.5	11.3	2.2	-2.5	-3.4	-2.5	-1.8
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.2	-0.1	-0.2	-0.1	0.2
Delay discount exponential model param	8.0	8.9	11.6	-3.3	3.4	3.1	3.4	1.2
Extinction: sum of active levers before priming	1.1	1.2	2.1	0.6	-0.8	-1.2	-1.1	-1.4
Active lever presses in extinction session 6	0.6	0.6	1.0	1.0	-0.9	-0.5	-0.9	0.1
Bone: final force	0.3	0.5	0.9	0.7	-0.7	-0.7	-0.9	0.0
Bone: final moment	0.4	0.6	0.8	0.9	-0.9	-0.9	-0.8	0.2
Food consumed during 24 hour testing period	0.4	0.6	2.1	-0.4	0.5	-0.8	0.2	-1.4
Glucose	12.0	19.0	45.7	2.2	-1.8	-5.4	-3.4	-6.8
Heart weight	0.4	0.7	1.8	0.5	-0.1	-0.5	-1.0	-1.3
Delay discount hyperbolic model param	8.3	9.2	12.0	-3.4	3.5	3.1	3.5	1.0
Intermittent access intake day 1-15 change	0.7	1.4	4.2	0.6	-0.6	-1.1	-1.0	-2.1
Intermittent access intake escalation	0.7	1.5	3.6	0.8	-0.8	-1.1	-1.1	-1.9
Intermittent access intake escalation 2	0.4	0.4	1.1	0.5	-0.3	-0.6	-0.5	-1.0
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.3	0.6	-0.6	-0.0	-0.5	0.3
Intermitt. access day 15 inactive lever presses	0.8	1.6	2.6	1.0	-1.0	-1.2	-1.4	-1.6
Intermitt. access escalation Index	0.6	0.9	1.8	-1.3	1.1	0.7	0.3	-0.9
Intermittent access day 1 total infusions	1.7	2.7	4.1	1.9	-2.0	-1.7	-1.7	0.2
Intermittent access day 15 total infusions	2.9	4.3	5.2	2.2	-2.3	-2.3	-2.2	-1.3
Intermittent access terminal intake (last 3 days)	2.0	2.6	3.5	1.8	-1.8	-1.9	-1.6	-0.9
Intermittent access total infusions	2.6	3.1	4.2	2.0	-2.1	-2.0	-1.6	-0.7
Intermittent access day 1 locomotion	0.1	0.1	0.4	-0.0	-0.1	-0.1	0.4	0.6
Intermittent access day 15 total locomotion	2.5	4.5	5.8	2.3	-2.1	-2.2	-2.4	-1.2
Intermittent access total locomotion	1.8	2.2	3.3	1.6	-1.6	-1.8	-1.2	-0.9
Intermittent access standard deviation	0.1	0.1	0.3	0.5	-0.4	-0.1	-0.3	0.4
Left kidney weight	0.3	1.3	3.2	1.4	-0.7	0.6	-0.8	1.8
Right kidney weight	0.7	3.1	7.9	1.9	-1.5	0.7	-1.0	2.8
Cocaine induced anxiety	1.2	1.7	2.2	1.3	-1.2	-1.3	-1.2	-1.5
Post-drug Anxiety	2.1	2.2	3.2	1.5	-1.4	-1.3	-1.8	-1.5
Baseline Anxiety	0.1	0.2	0.6	0.0	-0.1	-0.3	-0.8	-0.2
Tail length	1.1	4.1	8.2	2.9	-2.6	-1.7	-1.4	1.0
Length with tail	1.5	6.4	12.1	3.5	-3.1	-2.2	-2.2	0.6
Length without tail	0.8	2.7	4.5	2.1	-1.8	-1.4	-1.8	-0.4
Times rat made contact with spout	1.1	1.3	3.3	-1.2	1.1	-0.2	0.8	-1.8
Lifetime Intake	2.4	2.9	4.5	2.0	-2.1	-2.1	-1.4	-0.4
Liver weight, left	0.6	1.0	3.1	-0.1	0.0	1.3	0.6	1.8
Liver weight, right	0.5	0.9	2.0	-0.5	0.4	1.4	0.5	1.3
Locomotor activity	0.2	0.4	1.7	0.2	-0.0	-0.1	0.0	-1.3
Locomotor testing distance	0.5	1.0	2.3	1.5	-1.3	-0.0	-0.8	0.6
Locomotor testing rearing	0.9	1.7	2.9	1.7	-1.4	-1.2	-1.3	-0.7
Locomotion in novel chamber	0.6	0.8	1.7	-0.3	0.5	1.3	0.5	1.2
Locomotion in novel chamber post-restriction	1.4	2.2	4.4	-2.1	1.9	1.2	1.2	-0.7
Fecal boli incidents, locomotor time 1	0.4	0.5	0.9	-0.8	0.9	0.5	1.0	-0.1
Change in fecal boli incidents, locomotor task	0.8	0.8	1.2	-1.1	1.1	0.2	0.7	-1.0
Time >=10cm from walls, locomotor time 1	0.1	0.2	0.4	-0.3	0.1	-0.3	-0.6	-0.4
Bouts of movement, locomotor time 1	0.4	0.5	1.3	-0.2	0.0	-0.7	-0.6	-1.2
Total resting periods, locomotor time 1	0.6	0.6	1.9	-0.1	-0.0	-0.8	-0.8	-1.4
Rest time, locomotor task time 1	0.1	0.2	0.3	-0.5	0.5	0.2	0.2	-0.6
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.4	-0.4	-0.4	0.1	0.6
Vertical activity count, locomotor time 1	0.1	0.2	0.6	-0.3	-0.1	-0.4	0.8	0.3
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.6	-0.8	0.6	0.3	0.3	-0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.3	0.0	0.4	-0.5	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.2	0.0	0.3	-0.7	0.0
Rest time, locomotor task time 2	0.3	0.4	0.8	-0.9	0.7	0.5	0.7	-0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.1	0.3	-0.1	0.1	0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.2	-0.3	-0.3	0.1	0.1
Light reinforcement 1	0.3	0.6	1.2	1.1	-0.8	0.2	-1.0	0.6
Light reinforcement 2	0.2	0.3	1.0	0.5	-0.5	0.1	-0.2	1.0
Bone: marrow area	0.0	0.0	0.1	-0.0	0.0	-0.0	0.3	-0.1
Bone: maximum diameter	2.9	5.5	7.0	2.5	-2.1	-2.6	-2.6	-1.7
Bone: maximum force	0.2	0.4	0.5	0.6	-0.7	-0.6	-0.6	0.5
Bone: maximum moment	0.3	0.5	0.8	0.8	-0.9	-0.7	-0.4	0.7
Mean time between licks in bursts	0.5	1.2	1.7	-1.2	1.3	0.0	1.1	-1.3
Mean num. licks in bursts	1.5	2.4	4.6	-2.2	1.7	1.0	1.3	-1.2
Cd content in liver	0.4	0.4	1.2	0.3	-0.2	-0.8	-0.5	-1.1
Co content in liver	0.6	0.7	1.5	1.1	-1.2	-0.3	-0.9	0.2
Cu content in liver	0.1	0.1	0.2	0.1	-0.3	-0.4	-0.3	-0.3
Fe content in liver	1.0	1.2	2.5	-1.6	1.1	1.1	1.0	-0.1
K content in liver	3.6	3.4	6.0	2.3	-2.4	-1.4	-1.9	0.5
Mg content in liver	3.1	3.2	5.2	2.3	-2.1	-1.2	-2.2	-0.3
Mn content in liver	0.1	0.1	0.3	0.4	-0.5	0.1	0.1	0.5
Na content in liver	4.1	4.4	5.8	2.0	-2.3	-2.4	-2.2	-1.5
Rb content in liver	1.0	1.2	2.0	1.1	-1.4	-1.2	-1.1	-0.1
Se content in liver	2.3	2.7	4.6	2.2	-2.2	-1.4	-1.5	-0.0
Sr content in liver	2.7	2.4	4.4	1.4	-1.1	-2.1	-1.5	-1.5
Zn content in liver	0.1	0.1	0.3	0.6	-0.2	0.2	-0.0	0.4
Bone: minimum diameter	0.1	0.2	0.5	0.0	0.1	0.5	0.3	0.7
Time in familiar zone, hab. session 1	0.9	0.8	1.3	-1.2	1.1	0.2	1.1	0.6
Time in novel zone, hab. session 1	0.8	0.8	1.7	1.2	-1.3	-0.3	-0.7	0.1
Total zone transitions, hab. session 1	0.4	0.6	1.4	-1.2	0.9	0.3	0.9	-0.0
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.4	0.2	0.0	0.5	0.0
Locomotion velocity, hab. session 1	0.2	0.2	0.4	-0.7	0.6	0.3	0.4	-0.3
Time in familiar zone, hab. session 2	2.4	2.6	4.2	-2.1	1.9	1.2	1.7	0.8
Time in novel zone, hab. session 2	2.1	2.2	3.5	1.9	-1.7	-1.2	-1.5	-0.7
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.1	0.0	-0.2	-0.2	-0.5
Total locomotion distance, hab. session 2	0.3	0.4	1.0	0.2	-0.2	-0.7	-0.5	-1.0
Locomotion velocity, hab. session 2	0.4	0.5	0.9	0.5	-0.5	-0.8	-0.7	-1.0
Novel to familiar place preference ratio	1.5	1.6	2.9	0.9	-1.0	-1.2	-1.4	-1.7
Novelty place preference	1.4	1.5	2.7	0.9	-0.9	-1.2	-1.3	-1.6
Time in novel zone, NPP test	1.2	1.3	2.5	0.8	-0.8	-1.1	-1.2	-1.6
Total zone transitions, NPP test	0.2	0.3	1.1	-0.2	-0.2	0.6	0.2	1.1
Total locomotion distance, NPP test	0.1	0.1	0.3	0.1	-0.4	0.2	-0.1	0.5
Locomotion velocity, NPP test	0.1	0.2	0.4	0.3	-0.6	-0.0	-0.4	0.4
Intraocular pressure	0.5	0.7	2.2	-0.5	0.7	-0.6	-0.3	-1.5
Delta distance traveled before/after self-admin	0.2	0.2	0.7	0.6	-0.3	-0.1	-0.8	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.0	0.1	0.3	-0.1	0.5
Parametrial fat weight	2.0	4.8	15.3	0.4	-0.4	-2.2	-1.9	-3.9
Pavlov. Cond. lever latency	0.2	0.2	0.7	0.1	-0.2	-0.8	0.1	-0.6
Pavlov. Cond. magazine entry latency	1.4	1.8	2.6	-1.4	1.3	1.6	1.4	0.7
Pavlov. Cond. change in total contacts	0.4	0.4	0.8	0.6	-0.6	-0.5	-0.9	-0.7
Pavlov. Cond. index score	1.0	1.3	2.6	-1.1	1.0	1.6	0.9	0.9
Pavlov. Cond. latency score	0.9	1.1	2.2	-1.0	0.9	1.5	0.8	0.9
Pavlov. Cond. lever contacts	0.5	0.6	1.6	-0.5	0.6	1.3	0.3	0.7
Pavlov. Cond. magazine entry number	1.4	1.7	3.1	1.5	-1.3	-1.8	-1.2	-0.3
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.5	1.1	-1.2	-0.2	-0.6	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.1	-1.1	1.0	1.8	1.0	1.0
Pavlov. Cond. response bias	0.4	0.5	1.6	-0.5	0.5	1.3	0.5	0.5
Pavlov. Cond. lever latency	2.2	3.0	5.3	2.3	-2.2	-1.5	-1.5	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	-0.5	-0.3	-0.3	0.1
Pavlov. Cond. change in total contacts	0.3	0.5	1.5	-1.2	0.7	0.2	0.7	-0.3
Pavlov. Cond. index score	0.6	0.8	1.7	-1.3	1.1	0.7	0.8	-0.2
Pavlov. Cond. latency score	0.7	0.9	1.7	-1.3	1.1	0.9	0.9	0.0
Pavlov. Cond. lever contacts	2.2	3.0	5.3	-2.3	2.1	1.7	1.6	-0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	0.2	-0.1	0.6	0.0	0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	-0.3	0.5	0.7	0.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.7	-1.3	1.1	0.7	0.9	-0.1
Pavlov. Cond. response bias	1.0	1.3	2.6	-1.6	1.4	0.8	1.0	-0.6
Time in closed arm before self-admin	0.4	0.5	1.0	-0.2	0.7	0.7	0.6	1.0
Time in closed arm after self-admin	3.0	3.2	5.8	-1.4	1.8	2.4	1.5	1.7
Time in open arm before self-admin	0.0	0.0	0.2	-0.0	0.1	0.4	0.1	0.1
Time in open arm after self-admin	2.2	2.4	4.2	0.8	-1.2	-2.0	-1.4	-1.9
Bone: periosteal estimation	0.5	1.1	1.9	1.4	-1.2	-0.9	-1.1	0.0
Bone: periosteal perimeter	1.9	3.3	4.9	2.2	-2.0	-1.6	-2.2	-0.4
Bone: post-yield work	0.1	0.1	0.4	-0.2	-0.2	-0.6	0.5	-0.1
Progressive ratio test 1 active lever presses	1.8	2.2	3.9	1.6	-2.0	-1.7	-1.2	-0.4
Progressive ratio test 1 breakpoint	1.8	2.2	3.9	1.6	-2.0	-1.7	-1.3	-0.4
Progressive ratio test 1 inactive lever presses	3.2	4.6	7.2	2.1	-2.6	-2.7	-2.0	-0.9
Progressive ratio test 2 active lever presses	2.2	2.5	3.8	1.6	-1.6	-2.0	-1.6	-1.2
Progressive ratio test 2 breakpoint	2.0	2.3	3.4	1.4	-1.4	-1.8	-1.5	-1.2
Progressive ratio test 2 inactive lever presses	3.2	5.2	7.4	2.2	-2.0	-2.4	-2.7	-2.0
Incentive Sensitization - Responses	1.1	1.5	2.3	1.0	-0.8	-1.5	-1.4	-1.3
Incentive Sensitization - Breakpoint	1.1	1.4	2.0	1.0	-0.7	-1.4	-1.4	-1.2
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.4	0.9	-1.2	-0.5	-1.0	-0.0
Progressive ratio	0.2	0.4	0.8	0.5	-0.7	-0.9	-0.2	0.5
Food seeking constrained by brief footshock	3.5	4.2	7.0	2.6	-2.6	-1.9	-1.8	0.8
Seeking ratio, punishment vs. effort	0.3	0.4	0.8	0.9	-0.7	0.3	-0.6	0.2
Retroperitoneal fat weight	0.6	2.7	7.4	0.4	-0.1	-1.5	-2.0	-2.7
Reaction time number correct	0.4	0.8	1.3	-1.0	1.1	0.5	1.1	-0.5
Reaction time mean minus median	0.1	0.4	1.6	-0.1	0.2	-0.3	-0.2	-1.3
Reaction time mean minus median AUC	0.2	0.4	0.8	0.6	-0.4	-0.3	-0.9	-0.8
Reaction time num false alarms	1.0	1.3	2.2	1.4	-1.3	-0.8	-1.5	0.5
Reaction time num false alarms AUC	0.9	1.4	2.0	1.4	-1.3	-0.6	-1.4	0.9
Reaction time trials correct on left	0.4	0.8	1.3	-1.0	1.1	0.5	1.1	-0.5
Reaction time trials on left	0.4	0.8	1.4	-1.0	1.2	0.5	1.2	-0.5
Reaction time mean	0.0	0.1	0.3	-0.1	0.1	0.1	-0.1	-0.6
Reaction time mean AUC	0.0	0.0	0.1	-0.1	0.2	0.3	-0.1	-0.3
Median of all reaction times	0.0	0.0	0.1	-0.2	0.2	0.3	-0.0	-0.2
Reaction time omissions	0.2	0.3	0.8	-0.5	0.7	0.9	0.4	0.3
Reaction time false alarm rate	1.9	2.6	3.6	1.9	-1.9	-0.8	-1.9	1.2
Reaction time premature initiation rate	3.6	4.9	9.1	-1.9	2.0	3.0	1.9	2.1
Reaction time premature initiations	2.5	4.5	7.0	-2.1	2.2	2.6	2.1	1.4
Std. dev. reaction times	0.2	0.4	1.7	-0.0	0.2	-0.3	-0.5	-1.3
Reaction time trials completed	0.4	0.8	1.4	-1.0	1.2	0.5	1.2	-0.5
Reaction time trials AUC	0.4	0.7	1.3	-0.9	1.0	0.4	1.1	-0.4
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.5	0.2	0.1	-0.2	-0.2
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.0	-0.1
Latency to leave start box in cocaine runway	0.3	0.3	0.9	0.5	-1.0	-0.4	-0.3	0.4
Latency to leave start box in cocaine runway, F	0.9	1.0	1.7	1.2	-1.3	-0.6	-1.0	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	-0.2	-0.1	0.5	-0.5
Std. dev. time between licks in bursts	0.9	1.2	1.9	-1.3	1.3	0.8	1.4	0.4
Total sessions with >9 infusions	0.3	0.4	1.5	0.2	-0.4	0.4	0.4	1.2
Short access day 1 total inactive lever presses	2.4	3.1	5.2	2.0	-2.3	-2.1	-1.3	-0.3
Short access day 10 total inactive lever presses	0.1	0.2	0.5	0.4	-0.2	0.6	0.1	0.7
Short access day 1 total infusions	0.4	0.5	2.0	0.4	-0.7	-0.0	0.1	1.4
Short access day 10 total infusions	0.1	0.2	0.5	0.1	-0.4	-0.2	0.3	0.7
Short access total infusions	0.5	0.7	1.4	0.8	-1.2	-0.9	-0.1	0.8
Short access day 1 locomotion	0.9	1.1	3.3	-0.3	0.3	0.7	1.2	1.8
Short access day 10 total locomotion	1.6	2.9	6.2	-1.6	1.2	1.4	2.5	1.5
Short access total locomotion	2.6	3.2	5.7	-1.5	1.3	1.7	2.4	1.9
One hour access (0.3 mA shock)	1.7	1.9	3.7	1.2	-1.5	-1.9	-1.0	-1.1
Compulsive drug intake	2.5	2.9	3.7	-1.9	1.8	1.9	1.8	1.0
One hour access (shock baseline)	3.3	5.1	7.4	2.3	-2.5	-2.7	-2.0	-1.6
Social response proportion	0.9	1.0	3.2	-0.6	0.8	-0.7	0.2	-1.8
Social responses	0.8	1.0	4.1	-0.3	0.6	-0.7	-0.1	-2.0
Social time	0.8	1.1	2.3	-1.2	1.5	0.4	0.9	-0.8
Soleus weight	0.7	2.2	5.0	2.2	-1.8	-0.7	-0.9	1.1
Bone: stiffness	0.1	0.1	0.4	-0.2	-0.0	0.6	-0.3	0.1
Tibialis anterior weight	1.5	5.0	7.3	2.7	-2.6	-2.2	-2.3	-0.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	0.3	-0.2	-0.0	-0.6	0.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.3	0.0	0.5	0.1	0.3
Time to tail flick, test, before self-admin	0.9	0.9	2.7	-0.3	1.0	1.6	0.8	0.5
Time to tail flick, test, after self-admin	0.8	0.8	2.1	1.5	-1.1	-0.6	-0.6	0.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.6	0.3	0.2	0.6	-0.2
Delta time to tail flick, test, before/after SA	1.1	1.1	2.4	0.8	-1.0	-1.6	-0.8	-0.9
Tibia length	0.3	1.0	3.7	0.4	-0.4	0.9	0.2	1.9
Ambulatory time before self-admin	0.3	0.4	0.9	0.4	-0.9	-0.6	0.3	0.9
Ambulatory time after self-admin	0.4	0.5	1.5	0.2	-0.7	-0.2	0.4	1.2
Bone: tissue strength	0.3	0.3	0.7	-0.6	0.6	-0.1	0.9	0.1
Total heroin consumption	0.2	0.2	0.4	-0.5	0.4	0.4	0.6	0.3
Bone: trabecular number	0.5	0.7	2.7	-0.1	-0.0	0.7	0.7	1.7
Bone: trabecular spacing	1.1	1.4	3.4	0.7	-0.8	-1.8	-1.0	-1.3
Bone: trabecular thickness	1.9	2.4	4.0	-0.9	1.2	2.0	1.5	1.8
Bone: trabecular tissue density	0.3	0.5	1.3	-0.7	0.6	-0.3	0.1	-1.2
Water consumed over 24 hours	1.1	1.5	2.0	-1.4	1.3	-0.4	1.4	-1.2
Number of responses in last shaping day	0.1	0.1	0.1	-0.2	-0.1	0.4	-0.3	0.0