Hub : Genes

Tank

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr3_46163023_46164821 0.06 0.04 9.8e-05 0.04 0.03 0.04 0.04 1.6e-05 1.0e-04 1.1e-05 1.3e-05
2 Adipose intron excision ratio chr3_46180548_46189428 0.04 0.03 4.5e-03 0.02 0.01 0.01 0.01 6.1e-03 3.5e-02 5.5e-02 4.7e-02
3 Adipose alternative TSS NM_001164073.2 0.03 0.02 4.6e-03 0.02 0.01 0.01 0.01 2.7e-03 1.0e-02 9.9e-03 1.2e-02
4 Adipose isoform ratio XM_039104358.1 0.07 0.05 3.2e-03 0.01 0.01 0.01 0.01 2.1e-02 2.6e-02 5.8e-02 4.2e-02
5 Liver intron excision ratio chr3_46164939_46179789 0.05 0.03 4.7e-04 0 0.02 0 0.01 2.5e-01 4.3e-03 7.8e-02 4.5e-02
6 Adipose gene expression Tank 0.2 0.08 9.7e-15 0.08 0.1 0.1 0.1 6.4e-09 2.3e-11 3.6e-11 6.7e-11
7 Adipose alternative TSS NM_001164073.2 0.05 0.03 1.7e-03 0.02 0.01 0.01 0.01 1.5e-03 1.4e-02 7.6e-03 7.9e-03
8 Adipose isoform ratio XM_006234274.3 0.05 0.04 1.6e-03 0.02 0.01 0 0.01 3.6e-03 2.4e-02 3.6e-01 1.3e-02
9 Liver gene expression Tank 0.3 0.11 0.0e+00 0.14 0.14 0.14 0.14 1.1e-15 4.2e-15 6.9e-15 1.8e-15
10 Liver isoform ratio XM_006234274.3 0.05 0.03 2.0e-04 0.03 0.02 0.02 0.03 1.9e-04 9.7e-04 1.6e-03 6.4e-04
11 NAcc isoform ratio XM_039104351.1 0.04 0.02 3.5e-04 0.02 0.03 0.03 0.03 7.9e-04 5.2e-04 3.6e-04 2.9e-04
12 BLA gene expression Tank 0.12 0.07 2.8e-03 0.08 0.02 0.01 0.05 6.8e-05 3.4e-02 5.2e-02 9.2e-04
13 PL gene expression Tank 0.04 0.03 5.1e-03 0.02 0.01 0.01 0.02 2.0e-03 7.0e-03 6.0e-02 6.9e-03
14 NAcc isoform ratio XM_039104358.1 0.09 0.05 3.7e-05 0.04 0.04 0.04 0.04 1.7e-05 1.2e-05 3.9e-05 1.7e-05
15 Adipose intron excision ratio chr3_46114385_46149548 0.11 0.06 7.5e-07 0.05 0.04 0.03 0.04 4.6e-06 7.0e-05 2.1e-04 1.2e-05
16 NAcc alternative polyA XM_039104358.1 0.24 0.15 3.8e-07 0.05 0.06 0.06 0.06 6.7e-07 6.6e-08 1.0e-07 1.5e-07
17 NAcc alternative polyA NM_001164073.2 0.22 0.15 7.2e-07 0.06 0.06 0.06 0.06 1.4e-07 1.0e-07 1.5e-07 3.2e-07
18 Adipose alternative polyA XM_039104358.1 0.08 0.05 1.4e-03 0.01 0.02 0.01 0.01 9.9e-03 2.0e-03 1.9e-02 1.2e-02
19 Adipose alternative polyA NM_001164073.2 0.08 0.05 1.6e-03 0.01 0.02 0.01 0.01 1.1e-02 2.3e-03 3.2e-02 1.6e-02
20 NAcc gene expression Tank 0.13 0.06 2.5e-07 0.07 0.06 0.07 0.07 1.8e-08 7.2e-08 2.5e-08 2.8e-08
21 NAcc mRNA stability Tank 0.06 0.04 8.1e-03 0.02 0.02 0.01 0.02 2.6e-03 2.2e-03 2.6e-02 2.7e-03
22 Eye intron excision ratio chr3_46180548_46185786 0.3 0.17 6.0e-03 0.02 0.02 0.05 -0.02 1.5e-01 1.5e-01 6.1e-02 9.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.81.36.1-1.22.3-0.7-0.72.51.0-0.70.70.70.7-2.20.70.6-0.1-0.50.1-0.10.4-0.5-2.0-1.20.0
Area under the delay curve0.20.30.8-0.20.50.10.1-0.9-0.60.7-0.7-0.7-0.70.8-0.7-0.2-0.20.7-0.20.2-0.40.40.60.10.0
BMI with tail0.10.41.10.91.00.70.7-0.8-0.70.5-0.5-0.5-0.50.4-0.5-0.8-0.80.7-1.00.9-0.30.30.0-0.50.0
BMI without tail0.20.41.80.00.8-0.7-0.70.00.5-0.50.50.50.5-0.40.50.40.3-0.4-0.20.21.2-1.2-0.9-1.30.0
Body weight0.10.61.7-0.9-0.8-0.6-0.60.20.7-1.01.01.01.0-1.31.00.60.8-0.70.5-0.50.8-0.8-0.10.10.0
Weight adjusted by age1.21.35.30.0-1.21.01.0-0.8-1.01.1-1.1-1.1-1.1-0.1-1.1-1.0-0.90.9-0.80.9-1.61.61.82.30.0
Bone surface1.32.38.1-2.00.9-1.4-1.42.81.7-1.51.51.51.5-2.21.51.40.9-1.51.2-1.20.9-1.0-1.9-0.70.0
Bone volume1.11.97.9-1.61.7-1.1-1.12.81.5-1.11.11.11.1-2.21.11.10.4-1.10.8-0.80.9-0.9-2.2-1.20.0
Breakpoint value in progressive ratio session5.46.09.03.02.23.03.0-2.3-2.72.6-2.6-2.6-2.62.3-2.6-2.7-2.72.7-2.72.7-2.32.21.50.20.0
Number of licking bursts0.20.21.6-0.5-1.10.20.2-0.0-0.10.1-0.1-0.1-0.1-1.3-0.1-0.2-0.30.0-0.60.6-0.20.20.40.50.0
Context. condit. distance diff. score0.10.10.9-0.0-0.30.10.1-0.4-0.30.2-0.2-0.2-0.2-0.0-0.2-0.0-0.10.2-0.10.1-0.50.60.81.00.0
Locomotion velocity, session 10.10.10.90.0-0.9-0.1-0.1-0.20.1-0.30.30.30.31.00.30.10.3-0.10.4-0.40.1-0.10.10.00.0
Locomotion distance, session 10.10.11.6-0.3-1.2-0.2-0.20.00.1-0.20.20.20.20.00.20.10.20.10.2-0.1-0.00.10.40.60.0
Locomotion velocity, session 20.80.91.71.30.21.01.0-0.9-1.01.2-1.2-1.2-1.21.3-1.2-1.1-1.11.2-0.90.9-0.80.80.4-0.30.0
Locomotion distance, session 20.30.42.7-1.0-1.6-0.6-0.60.60.6-0.50.50.50.5-1.00.50.50.5-0.40.5-0.50.3-0.30.10.60.0
Locomotion velocity, session 30.20.20.40.30.40.20.20.2-0.30.6-0.6-0.6-0.60.2-0.6-0.3-0.50.5-0.40.4-0.60.60.10.20.0
Locomotion distance, session 30.60.72.0-1.2-0.6-1.0-1.01.41.0-0.70.70.70.7-0.80.71.00.8-0.91.0-0.90.5-0.5-0.60.10.0
Stereotopy head waving bouts, day 30.40.51.1-0.8-0.3-0.7-0.71.00.8-0.80.80.80.8-0.90.80.70.5-0.90.6-0.60.5-0.5-0.6-0.20.0
Stereotopy head waving duration, day 30.20.20.9-0.7-0.4-0.5-0.50.50.4-0.50.50.50.5-1.00.50.50.2-0.50.1-0.10.4-0.4-0.20.10.0
Locomotion velocity, session 70.00.00.10.10.2-0.1-0.10.00.1-0.10.10.10.10.00.10.20.1-0.10.2-0.20.0-0.00.0-0.10.0
Locomotion distance, session 70.20.21.5-0.2-1.10.00.0-0.3-0.20.3-0.3-0.3-0.3-0.5-0.3-0.0-0.10.10.0-0.0-0.50.61.01.20.0
Stereotopy head waving bouts, day 70.10.10.50.20.2-0.0-0.00.20.1-0.10.10.10.10.50.20.0-0.00.0-0.0-0.00.2-0.2-0.5-0.70.0
Stereotopy head waving duration, day 70.10.21.50.31.20.00.00.30.1-0.10.10.10.10.20.1-0.0-0.20.1-0.20.10.3-0.3-0.8-1.00.0
Locomotion velocity, session 80.10.10.30.1-0.20.10.1-0.1-0.20.4-0.4-0.4-0.4-0.5-0.4-0.1-0.30.4-0.30.3-0.10.10.10.00.0
Locomotion distance, session 80.30.42.9-0.2-1.30.10.1-0.5-0.40.4-0.4-0.4-0.4-0.2-0.4-0.1-0.20.4-0.20.2-0.80.91.41.70.0
Degree of sensitization distance1.51.52.81.30.11.31.3-1.7-1.41.3-1.3-1.3-1.30.4-1.3-1.4-1.21.3-1.31.3-1.31.31.40.90.0
Degree of sensitization stereotypy0.30.41.10.90.60.70.7-0.5-0.60.6-0.6-0.6-0.61.0-0.5-0.7-0.70.7-0.60.6-0.40.40.0-0.40.0
Conditioned locomotion0.40.51.2-0.0-0.60.60.6-0.7-0.70.7-0.7-0.7-0.7-0.4-0.7-0.7-0.70.8-0.90.9-0.70.80.91.10.0
Cocaine response after cond. corrected5.76.58.92.81.52.92.9-2.5-2.82.9-2.9-2.9-2.91.7-2.9-2.9-2.92.7-3.03.0-2.52.41.80.60.0
Cocaine response after cond. not corrected4.44.96.32.30.72.42.4-2.4-2.52.5-2.5-2.5-2.51.5-2.5-2.5-2.42.3-2.52.5-2.32.22.11.10.0
Cocaine response before conditioning0.80.92.5-1.1-1.6-1.1-1.10.30.8-1.01.01.01.0-0.21.01.11.3-1.01.2-1.20.7-0.60.30.70.0
Saline control response0.20.31.4-0.0-0.80.30.3-0.7-0.50.4-0.4-0.4-0.40.6-0.4-0.3-0.10.4-0.20.2-0.60.71.01.20.0
Bone: connectivity density0.50.84.1-1.41.5-0.6-0.62.00.8-0.70.70.70.7-2.00.70.5-0.0-0.50.1-0.10.2-0.2-1.2-0.20.0
Bone: cortical apparent density0.30.41.8-0.21.4-0.5-0.50.90.7-0.40.40.40.4-0.20.40.60.4-0.50.6-0.60.7-0.7-1.1-1.20.0
Bone: cortical area1.62.44.4-2.1-0.9-1.6-1.61.81.7-1.71.71.71.7-1.71.71.71.6-1.71.7-1.71.2-1.2-0.90.00.0
Bone: cortical porosity1.82.04.0-0.90.7-1.4-1.41.51.6-1.51.51.51.5-0.51.41.41.4-1.41.4-1.51.7-1.7-2.0-1.80.0
Bone: cortical porosity3.13.45.0-1.60.1-1.9-1.92.02.0-2.02.02.02.0-1.02.01.91.9-1.92.0-2.02.0-2.0-2.2-1.60.0
Bone: cortical thickness1.72.83.7-1.7-0.2-1.8-1.81.91.9-1.81.81.81.8-1.41.71.81.7-1.81.8-1.81.8-1.8-1.8-1.20.0
Bone: cortical thickness5.36.17.8-2.7-0.8-2.7-2.72.82.8-2.82.82.82.8-1.82.72.72.6-2.72.7-2.72.5-2.4-2.3-1.30.0
Bone: cortical tissue density0.30.42.2-0.11.5-0.4-0.40.90.6-0.30.30.30.3-0.20.30.60.3-0.40.5-0.50.6-0.7-1.1-1.20.0
Condit. Reinf. active minus inactive responses3.64.16.5-2.6-1.3-2.2-2.22.52.3-2.22.22.22.2-1.82.22.22.0-2.22.0-2.01.9-1.9-1.8-0.70.0
Condit. Reinf. active-inactive response ratio1.21.32.8-1.7-0.8-1.2-1.21.41.2-1.21.21.21.2-1.21.21.21.1-1.21.0-1.01.0-0.9-0.7-0.00.0
Condit. Reinf. active responses3.74.66.0-2.2-1.2-2.4-2.42.42.5-2.22.22.22.2-1.22.22.42.3-2.32.3-2.32.3-2.3-2.2-1.40.0
Condit. Reinf. inactive responses3.03.67.2-1.00.1-2.0-2.01.92.1-1.71.71.71.7-0.51.72.01.9-1.92.1-2.12.4-2.5-2.7-2.60.0
Incentive salience index mean3.44.16.7-2.6-1.7-2.3-2.32.52.3-2.22.22.22.2-1.62.22.32.1-2.22.3-2.21.7-1.7-1.5-0.40.0
Condit. Reinf. lever presses0.40.61.6-0.8-1.3-0.8-0.80.60.7-0.80.80.80.80.10.80.80.9-0.81.2-1.10.4-0.4-0.20.20.0
Condit. Reinf. active minus inactive responses2.93.616.7-2.7-4.1-1.7-1.70.61.5-1.91.91.91.9-1.01.91.72.2-1.82.2-2.10.8-0.70.82.30.0
Condit. Reinf. active-inactive response ratio2.02.17.9-2.0-2.8-1.4-1.40.51.2-1.51.51.51.5-0.91.51.41.8-1.41.7-1.70.8-0.70.41.50.0
Condit. Reinf. active responses2.43.316.8-2.7-4.1-1.5-1.50.61.4-1.81.81.81.8-1.01.81.62.1-1.62.0-2.00.7-0.60.92.30.0
Condit. Reinf. inactive responses0.10.21.4-0.3-1.20.00.0-0.2-0.1-0.10.10.10.10.20.10.00.20.00.2-0.2-0.30.40.71.00.0
Condit. Reinf. lever presses1.11.510.2-1.9-3.2-0.8-0.80.20.6-0.90.90.90.9-0.60.90.91.2-0.91.2-1.2-0.10.21.22.50.0
Condit. Reinf. lever reinforcers received1.72.415.8-2.3-4.0-1.0-1.00.10.9-1.31.31.31.3-0.61.31.21.6-1.11.6-1.50.2-0.11.42.70.0
Conditioned reinforcement - actives0.50.52.6-1.6-0.6-0.7-0.71.00.6-0.40.40.40.4-1.40.40.40.5-0.50.6-0.60.2-0.1-0.20.50.0
Conditioned reinforcement - inactives0.30.41.1-0.2-0.4-0.5-0.5-0.30.5-0.60.60.60.61.00.60.61.0-0.20.8-0.80.8-0.8-0.1-0.40.0
Conditioned locomotion0.10.10.80.3-0.20.00.0-0.5-0.0-0.10.10.10.10.90.00.00.4-0.20.4-0.40.1-0.00.10.10.0
Patch foraging indifference point 0 sec0.20.41.4-0.20.7-0.4-0.41.10.5-0.50.50.50.5-1.20.50.2-0.1-0.10.0-0.00.4-0.5-1.1-1.00.0
Patch foraging indifference point AUC0.30.32.7-0.2-1.70.00.0-0.7-0.0-0.30.30.30.31.10.30.10.6-0.00.5-0.50.00.00.90.90.0
Delay disc. indifference point, 0s delay0.00.00.2-0.10.4-0.5-0.5-0.20.0-0.00.00.00.00.10.10.20.10.3-0.10.10.2-0.20.30.10.0
Delay disc. indifference point, 16s delay0.30.31.0-0.71.0-0.6-0.60.60.4-0.30.30.30.3-0.30.30.50.3-0.20.2-0.30.6-0.6-0.9-1.00.0
Delay disc. indifference point, 2s delay0.70.81.7-1.1-0.7-0.8-0.8-0.10.8-0.90.90.90.90.70.91.11.3-0.61.1-1.11.2-1.2-0.4-0.60.0
Delay disc. indifference point, 24s delay0.60.51.2-0.30.20.70.7-0.9-0.80.8-0.8-0.8-0.80.5-0.8-0.7-0.60.9-0.60.6-0.90.91.10.90.0
Delay disc. indifference point, 4s delay0.80.92.10.1-0.40.80.8-1.3-1.01.0-1.0-1.0-1.01.2-1.0-0.8-0.51.1-0.50.5-1.01.11.51.20.0
Delay disc. indifference point, 8s delay0.30.30.7-0.00.70.30.3-0.7-0.70.8-0.8-0.8-0.80.3-0.8-0.3-0.50.7-0.40.4-0.60.60.50.20.0
Indifference point function ln k0.70.92.6-1.10.1-1.2-1.21.61.1-0.80.80.80.8-1.60.81.20.6-0.90.6-0.60.9-0.9-1.3-0.80.0
Indifference point function log k0.70.92.6-1.10.1-1.2-1.21.61.1-0.80.80.80.8-1.60.81.20.6-0.90.6-0.60.9-0.9-1.3-0.80.0
Patch foraging total patch changes 0 sec0.10.20.80.00.8-0.1-0.10.80.2-0.20.20.20.2-0.90.20.0-0.30.2-0.30.20.2-0.2-0.9-0.90.0
Patch foraging total patch changes 12 sec0.60.81.5-0.4-0.7-0.6-0.60.50.9-1.21.21.21.20.21.20.91.1-0.71.2-1.21.0-1.0-0.7-0.70.0
Patch foraging total patch changes 18 sec1.01.32.3-0.6-0.1-1.0-1.01.21.2-1.31.31.31.3-0.61.31.01.0-0.91.1-1.11.4-1.4-1.5-1.40.0
Patch foraging total patch changes 24 sec1.11.32.1-1.4-1.3-1.1-1.11.01.2-1.41.41.41.4-0.91.41.11.2-1.11.0-1.01.1-1.1-0.8-0.20.0
Patch foraging total patch changes 6 sec0.20.32.00.61.40.50.50.1-0.30.2-0.2-0.2-0.20.0-0.2-0.5-0.70.5-0.60.6-0.20.2-0.3-0.70.0
Patch foraging time to switch 0 sec0.71.13.71.51.91.31.3-0.4-0.91.0-1.0-1.0-1.00.7-1.0-1.1-1.30.9-1.01.0-0.80.7-0.3-0.90.0
Patch foraging water rate 0 sec2.43.97.8-2.8-2.3-2.4-2.41.92.1-2.12.12.12.1-2.32.12.22.1-1.81.9-1.91.5-1.5-0.70.70.0
Patch foraging water rate 12 sec2.94.57.5-2.5-1.2-2.7-2.72.22.4-2.12.12.12.1-2.72.12.52.1-2.41.8-1.82.2-2.2-1.5-0.50.0
Patch foraging water rate 18 sec4.46.010.1-2.7-2.1-3.2-3.21.92.6-2.62.62.62.6-1.52.62.92.9-2.72.8-2.82.5-2.4-1.3-0.20.0
Patch foraging water rate 24 sec1.92.75.6-2.3-1.7-2.4-2.41.61.8-1.51.51.51.5-1.71.52.01.8-1.61.6-1.61.3-1.3-0.50.60.0
Patch foraging water rate 6 sec3.75.48.9-3.0-2.4-2.7-2.72.22.5-2.62.62.62.6-2.12.62.62.5-2.42.3-2.32.2-2.1-1.20.10.0
Seeking ratio, delayed vs. immediate footshock0.20.20.4-0.60.1-0.6-0.60.60.4-0.60.60.60.60.20.60.20.4-0.50.5-0.50.3-0.3-0.6-0.30.0
Distance traveled before self-admin2.93.14.7-1.1-0.4-2.1-2.12.02.1-1.61.61.61.6-1.51.72.11.8-1.81.8-1.82.2-2.2-1.9-1.50.0
Distance traveled after self-admin2.83.14.9-1.5-0.6-2.1-2.12.12.0-1.91.91.91.9-2.21.71.91.6-1.71.5-1.62.0-2.0-1.7-1.10.0
Extensor digitorum longus weight0.31.04.7-1.5-0.3-1.0-1.01.71.1-1.01.01.01.0-2.21.00.90.6-0.80.8-0.70.6-0.5-0.80.10.0
Bone: elastic displacement0.10.10.2-0.4-0.1-0.2-0.20.10.2-0.40.40.40.4-0.30.40.20.2-0.20.1-0.10.2-0.2-0.10.10.0
Bone: elastic work0.91.13.5-1.9-1.5-0.9-0.91.20.8-1.11.11.11.1-1.81.10.90.7-0.90.8-0.80.00.00.21.40.0
Bone: endosteal estimation0.30.62.0-1.2-1.4-0.6-0.60.50.6-0.70.70.70.7-0.50.70.70.8-0.80.9-0.90.2-0.10.31.00.0
Bone: endosteal perimeter0.30.64.1-1.0-2.0-0.5-0.5-0.20.1-0.50.50.50.5-0.40.50.30.6-0.40.6-0.6-0.30.31.11.80.0
Epididymis fat weight7.718.023.44.72.24.84.8-3.9-4.74.6-4.6-4.6-4.63.3-4.6-4.7-4.74.8-4.44.4-4.84.83.72.20.0
Delta time in closed arm before/after self-admin0.60.61.20.5-0.41.11.1-1.1-0.80.7-0.7-0.7-0.70.6-0.8-0.9-0.50.8-0.70.7-0.70.71.00.90.0
Delta time in open arm before/after self-admin1.41.32.3-0.60.2-1.5-1.51.41.4-1.11.11.11.1-0.41.21.11.1-1.21.1-1.11.4-1.5-1.4-1.30.0
Diff in mean of infusions in LGA sessions11.813.017.63.43.34.24.2-3.6-4.14.1-4.1-4.1-4.13.1-4.1-4.0-4.03.9-3.73.7-3.53.52.20.30.0
Delay discount exponential model param0.30.30.90.1-0.5-0.2-0.21.00.7-0.80.80.80.8-0.90.80.30.4-0.80.3-0.30.5-0.5-0.6-0.20.0
Extinction: sum of active levers before priming0.40.44.92.21.0-0.1-0.1-0.6-0.20.2-0.2-0.2-0.21.2-0.10.1-0.10.5-0.10.10.3-0.3-0.3-1.20.0
Active lever presses in extinction session 60.40.41.71.01.30.60.6-0.6-0.40.4-0.4-0.4-0.40.5-0.2-0.8-0.50.7-0.50.50.1-0.1-0.3-1.20.0
Bone: final force2.43.99.4-2.9-1.0-2.2-2.22.62.1-2.12.12.12.1-3.12.12.11.7-2.21.8-1.81.4-1.4-1.30.20.0
Bone: final moment2.54.19.9-2.9-1.0-2.2-2.22.72.2-2.12.12.12.1-3.12.12.11.7-2.21.8-1.81.5-1.5-1.5-0.00.0
Food consumed during 24 hour testing period0.60.85.3-1.4-1.6-0.7-0.71.20.7-0.70.70.70.7-2.30.70.70.3-0.70.3-0.30.3-0.3-0.20.50.0
Glucose0.30.40.8-0.9-0.1-0.7-0.70.60.8-0.70.70.70.7-0.80.70.70.7-0.50.5-0.60.9-0.9-0.7-0.40.0
Heart weight0.20.20.6-0.2-0.0-0.5-0.50.60.5-0.50.50.50.5-0.80.40.70.4-0.20.7-0.60.4-0.4-0.4-0.40.0
Delay discount hyperbolic model param0.20.31.20.1-0.2-0.1-0.11.00.6-0.60.60.60.6-1.10.60.20.1-0.70.2-0.20.3-0.3-0.6-0.10.0
Intermittent access intake day 1-15 change3.23.24.6-1.4-0.7-1.8-1.81.92.1-2.12.12.12.1-1.32.11.81.9-2.11.7-1.71.9-1.8-1.7-0.60.0
Intermittent access intake escalation3.23.14.9-1.2-0.4-1.7-1.71.92.1-2.12.12.12.1-0.92.11.82.0-2.21.7-1.82.0-2.0-1.9-0.90.0
Intermittent access intake escalation 22.22.23.3-0.9-0.6-1.8-1.81.71.8-1.61.61.61.6-0.91.61.61.6-1.81.4-1.51.7-1.7-1.6-0.70.0
Intermitt. access day 1 inactive lever presses0.60.62.50.5-0.91.01.0-0.7-0.80.4-0.4-0.4-0.41.1-0.3-0.4-0.40.6-0.50.5-1.11.21.31.60.0
Intermitt. access day 15 inactive lever presses0.20.20.50.2-0.7-0.6-0.6-0.60.1-0.20.20.20.20.70.20.50.50.20.1-0.20.6-0.50.3-0.00.0
Intermitt. access escalation Index0.60.61.5-1.2-0.5-0.2-0.20.50.6-1.01.01.01.00.31.10.40.9-0.71.2-1.20.3-0.3-0.5-0.00.0
Intermittent access day 1 total infusions0.50.64.90.81.9-0.2-0.2-0.5-0.10.2-0.2-0.2-0.21.3-0.2-0.00.10.30.4-0.50.7-0.8-0.8-2.20.0
Intermittent access day 15 total infusions1.71.95.0-0.20.9-1.1-1.10.61.4-1.41.41.41.40.71.31.11.6-1.31.6-1.72.0-2.0-1.8-2.20.0
Intermittent access terminal intake (last 3 days)1.81.93.7-0.50.1-1.3-1.30.31.4-1.51.51.51.50.91.41.21.9-1.21.8-1.81.9-1.9-1.4-1.70.0
Intermittent access total infusions1.61.86.4-0.31.0-1.3-1.30.41.3-1.11.11.11.10.31.01.21.5-1.11.5-1.52.1-2.1-1.7-2.50.0
Intermittent access day 1 locomotion0.70.74.41.51.80.60.6-1.0-0.80.4-0.4-0.4-0.42.1-0.5-0.6-0.50.8-0.30.3-0.20.2-0.1-1.30.0
Intermittent access day 15 total locomotion0.60.61.10.50.3-0.6-0.6-0.10.6-1.11.11.11.10.81.00.60.9-0.70.9-0.90.9-0.9-0.7-0.80.0
Intermittent access total locomotion0.30.31.81.00.4-0.2-0.2-0.60.1-0.50.50.50.51.40.40.20.5-0.10.6-0.60.5-0.5-0.2-0.70.0
Intermittent access standard deviation2.93.17.80.01.5-1.6-1.61.41.7-1.91.91.91.9-0.11.81.71.5-1.71.4-1.52.3-2.4-2.5-2.80.0
Left kidney weight0.72.09.8-1.7-3.1-0.9-0.90.11.1-1.51.51.51.5-0.91.51.11.8-1.21.8-1.70.7-0.60.91.80.0
Right kidney weight0.92.410.6-2.1-3.3-1.0-1.00.51.2-1.71.71.71.7-0.91.81.31.8-1.51.7-1.70.7-0.60.72.00.0
Cocaine induced anxiety0.40.51.0-0.2-0.30.90.9-0.9-0.80.7-0.7-0.7-0.70.3-0.7-0.8-0.50.6-0.50.5-0.80.81.00.90.0
Post-drug Anxiety0.40.41.20.2-0.30.90.9-1.1-0.70.8-0.8-0.8-0.80.6-0.8-0.8-0.40.6-0.20.2-0.60.70.90.60.0
Baseline Anxiety0.20.20.60.20.1-0.6-0.60.50.5-0.40.40.40.40.10.40.50.4-0.20.7-0.70.4-0.5-0.6-0.70.0
Tail length1.33.95.8-2.0-1.4-2.2-2.21.32.1-2.32.32.32.3-2.02.32.12.2-2.21.6-1.72.4-2.4-1.1-0.60.0
Length with tail0.72.43.7-1.9-1.9-1.5-1.51.21.6-1.81.81.81.8-1.91.81.71.8-1.61.7-1.71.4-1.3-0.30.40.0
Length without tail0.30.62.9-1.1-1.7-0.3-0.30.60.6-0.70.70.70.7-0.80.70.60.8-0.61.2-1.1-0.10.20.41.20.0
Times rat made contact with spout3.84.45.82.20.12.32.3-2.4-2.42.4-2.4-2.4-2.41.4-2.4-2.3-2.22.3-2.32.3-2.12.12.11.20.0
Lifetime Intake1.82.17.7-0.61.5-1.4-1.40.91.4-1.21.21.21.2-0.21.11.21.3-1.11.4-1.52.0-2.1-2.0-2.80.0
Liver weight, left0.00.10.3-0.1-0.40.20.2-0.4-0.20.1-0.1-0.1-0.1-0.4-0.0-0.2-0.10.2-0.20.2-0.20.20.50.60.0
Liver weight, right0.20.31.7-0.1-0.80.40.4-0.6-0.5-0.00.00.00.00.4-0.0-0.5-0.20.3-0.10.1-0.80.91.01.30.0
Locomotor activity2.33.76.2-2.5-1.4-2.1-2.12.02.1-2.32.32.32.3-1.72.31.92.0-2.12.0-2.01.7-1.6-1.4-0.10.0
Locomotor testing distance5.28.713.0-3.6-1.6-3.2-3.23.13.3-3.43.43.43.4-2.83.43.03.1-3.23.0-3.02.8-2.8-2.3-0.70.0
Locomotor testing rearing5.68.612.1-3.0-2.4-3.2-3.22.33.1-3.43.43.43.4-1.23.53.03.5-3.23.4-3.43.0-2.9-2.0-0.90.0
Locomotion in novel chamber0.91.11.90.90.61.41.4-1.1-1.21.0-1.0-1.0-1.01.2-1.0-1.3-1.10.9-0.90.9-1.21.20.80.40.0
Locomotion in novel chamber post-restriction0.60.71.8-0.4-0.1-0.7-0.70.70.9-1.01.01.01.0-0.00.90.80.8-0.80.3-0.31.3-1.3-1.2-1.10.0
Fecal boli incidents, locomotor time 10.50.51.8-0.30.2-0.9-0.91.30.8-0.40.40.40.4-0.90.40.90.3-0.40.8-0.80.5-0.5-1.2-1.00.0
Change in fecal boli incidents, locomotor task0.10.10.5-0.0-0.0-0.0-0.0-0.0-0.0-0.10.10.10.1-0.70.1-0.0-0.20.1-0.70.70.0-0.00.30.60.0
Time >=10cm from walls, locomotor time 10.30.30.7-0.5-0.8-0.3-0.30.80.6-0.80.80.80.8-0.80.80.30.4-0.60.5-0.50.3-0.3-0.20.30.0
Bouts of movement, locomotor time 11.41.53.30.81.81.51.5-1.1-1.51.0-1.0-1.0-1.00.3-1.1-1.7-1.71.5-1.61.6-1.11.00.4-0.50.0
Total resting periods, locomotor time 11.21.32.70.81.71.51.5-1.2-1.40.8-0.8-0.8-0.80.8-0.9-1.6-1.51.4-1.41.4-1.00.90.3-0.60.0
Rest time, locomotor task time 11.01.11.91.01.31.01.0-1.3-1.21.0-1.0-1.0-1.01.1-1.1-1.2-1.21.2-1.41.3-0.60.60.2-0.80.0
Distance moved, locomotor task time 12.22.54.0-1.5-2.0-1.7-1.71.51.8-1.61.61.61.6-1.61.61.81.9-1.91.8-1.81.3-1.3-0.50.70.0
Vertical activity count, locomotor time 10.30.40.7-0.7-0.4-0.8-0.80.30.6-0.60.60.60.6-0.60.70.80.7-0.70.6-0.60.6-0.6-0.10.10.0
Time >=10cm from walls, locomotor time 20.40.41.81.3-1.30.30.3-0.9-0.40.0-0.0-0.0-0.01.3-0.1-0.60.20.30.3-0.2-0.40.51.00.80.0
Bouts of movement, locomotor time 20.60.73.21.21.81.01.0-0.3-0.80.2-0.2-0.2-0.21.5-0.3-0.9-0.91.1-0.60.6-0.70.7-0.2-0.80.0
Total resting periods, locomotor time 20.80.93.91.22.01.11.1-0.3-0.90.3-0.3-0.3-0.31.6-0.4-1.0-1.01.3-0.80.8-0.80.8-0.2-0.90.0
Rest time, locomotor task time 20.30.43.20.41.80.30.3-0.1-0.30.1-0.1-0.1-0.10.1-0.2-0.4-0.70.6-0.70.60.0-0.1-0.6-1.30.0
Distance moved, locomotor task time 21.01.28.7-0.5-2.9-1.2-1.20.11.0-0.70.70.70.7-0.60.81.01.4-1.31.1-1.10.8-0.70.61.40.0
Vertical activity count, locomotor time 20.10.10.20.3-0.5-0.4-0.4-0.50.00.1-0.1-0.1-0.10.2-0.00.10.2-0.20.0-0.10.3-0.30.2-0.00.0
Light reinforcement 10.50.82.60.0-1.6-0.7-0.7-1.00.5-0.80.80.80.81.60.80.61.4-0.61.1-1.11.1-1.00.3-0.10.0
Light reinforcement 20.50.73.8-0.4-2.0-0.4-0.4-0.80.4-0.60.60.60.61.50.60.41.3-0.61.1-1.10.5-0.40.80.90.0
Bone: marrow area0.30.62.1-1.2-1.4-0.6-0.60.50.6-0.70.70.70.7-0.50.80.70.8-0.90.9-0.90.2-0.10.31.00.0
Bone: maximum diameter0.30.62.4-1.5-1.2-0.6-0.60.90.6-0.60.60.60.6-1.50.60.70.5-0.70.5-0.5-0.00.10.51.30.0
Bone: maximum force2.54.37.7-2.8-1.0-2.3-2.32.62.3-2.22.22.22.2-2.42.22.22.0-2.32.3-2.21.6-1.6-1.5-0.10.0
Bone: maximum moment2.64.57.8-2.8-1.1-2.4-2.42.72.4-2.32.32.32.3-2.42.32.32.1-2.32.3-2.31.7-1.7-1.7-0.30.0
Mean time between licks in bursts0.20.21.10.3-0.80.10.1-0.7-0.50.4-0.4-0.4-0.40.3-0.4-0.1-0.20.4-0.20.2-0.50.61.00.90.0
Mean num. licks in bursts1.11.33.51.61.31.01.0-1.2-1.21.3-1.3-1.3-1.31.9-1.3-1.1-1.01.2-0.70.7-1.11.00.70.00.0
Cd content in liver0.60.70.90.9-0.21.01.0-0.8-0.90.9-0.9-0.9-0.90.5-0.9-1.0-0.90.9-0.90.9-1.00.90.70.50.0
Co content in liver0.30.31.9-0.9-1.4-0.2-0.20.50.3-0.50.50.50.5-1.30.50.10.1-0.4-0.10.10.0-0.00.10.70.0
Cu content in liver0.60.81.3-0.9-0.8-0.9-0.90.60.9-1.11.11.11.1-0.11.00.91.1-1.11.1-1.10.8-0.8-0.4-0.00.0
Fe content in liver0.10.10.30.50.20.30.3-0.3-0.30.5-0.5-0.5-0.50.5-0.5-0.3-0.30.3-0.30.3-0.30.30.2-0.00.0
K content in liver0.30.31.2-0.9-0.9-0.5-0.50.10.4-0.50.50.50.5-0.80.40.50.5-0.50.4-0.40.1-0.00.61.10.0
Mg content in liver0.40.42.7-1.0-0.8-0.4-0.40.30.2-0.30.30.30.3-1.70.20.30.2-0.40.1-0.1-0.30.30.91.60.0
Mn content in liver4.65.214.1-3.6-2.0-2.6-2.62.72.4-2.42.42.42.4-3.72.32.52.0-2.51.8-1.81.5-1.4-0.71.10.0
Na content in liver2.02.13.3-1.8-1.4-1.6-1.61.11.5-1.71.71.71.7-1.21.61.61.7-1.71.6-1.61.2-1.1-0.30.50.0
Rb content in liver0.30.42.6-1.1-0.5-0.2-0.20.00.1-0.40.40.40.4-1.20.30.20.3-0.40.3-0.2-0.30.41.01.60.0
Se content in liver0.81.02.01.41.21.01.0-0.8-1.01.0-1.0-1.0-1.00.7-1.1-1.1-1.21.0-1.21.2-0.80.80.3-0.20.0
Sr content in liver0.90.81.6-0.3-0.2-0.9-0.90.50.9-0.80.80.80.80.60.80.91.1-0.91.0-1.01.2-1.3-1.1-1.20.0
Zn content in liver0.91.01.60.80.61.21.2-0.6-1.11.0-1.0-1.0-1.00.0-1.1-1.2-1.31.0-1.21.2-1.21.20.80.70.0
Bone: minimum diameter0.40.71.5-1.1-0.8-0.8-0.80.60.8-0.90.90.90.9-0.30.90.81.0-0.91.2-1.20.5-0.5-0.20.30.0
Time in familiar zone, hab. session 10.40.41.50.0-1.00.60.6-0.4-0.60.4-0.4-0.4-0.4-0.3-0.4-0.6-0.60.6-0.50.5-0.91.01.01.20.0
Time in novel zone, hab. session 10.30.31.80.71.30.40.4-0.5-0.40.7-0.7-0.7-0.70.8-0.7-0.4-0.30.4-0.40.3-0.00.0-0.0-0.50.0
Total zone transitions, hab. session 11.41.912.3-1.7-3.5-1.4-1.40.51.1-1.31.31.31.3-1.01.31.31.5-1.11.4-1.40.7-0.60.61.50.0
Total locomotion distance, hab. session 12.02.910.7-2.0-3.3-2.0-2.00.81.6-1.71.71.71.7-0.81.71.92.1-1.62.0-2.01.3-1.20.21.00.0
Locomotion velocity, hab. session 11.31.96.7-1.5-2.6-1.6-1.60.51.3-1.41.41.41.4-0.31.41.51.8-1.31.7-1.71.1-1.10.10.70.0
Time in familiar zone, hab. session 22.42.54.41.10.11.81.8-1.4-1.81.5-1.5-1.5-1.50.6-1.5-1.8-1.81.5-1.71.7-2.12.11.81.80.0
Time in novel zone, hab. session 21.21.22.5-0.60.5-1.2-1.21.11.2-0.90.90.90.9-0.50.91.21.1-1.01.1-1.11.5-1.5-1.6-1.60.0
Total zone transitions, hab. session 20.70.94.8-1.3-2.2-0.9-0.90.70.7-0.80.80.80.8-1.30.80.90.8-0.70.9-0.90.2-0.20.51.30.0
Total locomotion distance, hab. session 20.70.92.0-1.3-1.4-1.1-1.11.11.0-0.90.90.90.9-1.10.91.11.0-0.91.2-1.10.5-0.5-0.30.40.0
Locomotion velocity, hab. session 20.50.72.6-1.1-1.6-1.0-1.00.80.8-0.80.80.80.8-0.70.81.00.9-0.71.1-1.10.4-0.4-0.00.60.0
Novel to familiar place preference ratio1.01.01.70.9-0.21.01.0-1.2-1.11.1-1.1-1.1-1.11.2-1.1-1.0-0.91.0-0.90.9-1.11.11.31.00.0
Novelty place preference1.11.11.71.10.01.11.1-1.3-1.21.1-1.1-1.1-1.11.3-1.1-1.1-0.91.1-1.01.0-1.01.01.20.80.0
Time in novel zone, NPP test1.01.01.71.10.31.01.0-1.1-1.11.1-1.1-1.1-1.11.3-1.1-1.0-1.01.1-1.01.0-1.01.00.90.50.0
Total zone transitions, NPP test0.40.64.0-0.5-2.00.10.1-0.2-0.30.2-0.2-0.2-0.2-0.9-0.2-0.1-0.20.4-0.00.1-0.80.91.42.00.0
Total locomotion distance, NPP test0.50.75.1-1.1-2.3-0.8-0.80.30.6-0.70.70.70.7-0.70.70.80.9-0.61.0-0.90.1-0.10.71.30.0
Locomotion velocity, NPP test0.70.96.4-1.3-2.5-0.9-0.90.20.6-0.80.80.80.8-0.70.80.81.0-0.61.0-0.90.2-0.10.81.50.0
Intraocular pressure1.11.52.3-1.3-0.6-1.1-1.11.31.4-1.51.51.51.5-1.41.41.21.0-1.30.7-0.81.5-1.5-1.3-1.00.0
Delta distance traveled before/after self-admin0.10.10.4-0.0-0.10.40.4-0.6-0.50.2-0.2-0.2-0.20.1-0.4-0.4-0.30.5-0.40.4-0.40.40.60.40.0
Delta ambulatory time before/after self-admin0.40.51.1-1.1-0.8-0.7-0.70.50.6-0.90.90.90.9-0.60.70.60.7-0.60.7-0.70.6-0.5-0.20.10.0
Parametrial fat weight4.18.110.93.11.43.33.3-3.3-3.23.2-3.2-3.2-3.22.4-3.2-3.2-2.83.1-2.82.8-2.72.72.61.10.0
Pavlov. Cond. lever latency0.40.52.41.20.50.60.6-1.2-0.70.7-0.7-0.7-0.71.6-0.7-0.6-0.40.5-0.70.6-0.0-0.00.1-0.70.0
Pavlov. Cond. magazine entry latency0.10.10.3-0.10.50.30.30.4-0.20.3-0.3-0.3-0.3-0.1-0.3-0.4-0.40.1-0.00.1-0.60.6-0.00.20.0
Pavlov. Cond. change in total contacts0.91.02.9-1.3-0.2-1.1-1.11.71.1-1.01.01.01.0-1.11.01.10.8-1.01.2-1.20.6-0.6-1.0-0.30.0
Pavlov. Cond. index score0.30.41.7-1.2-0.6-0.5-0.51.10.5-0.60.60.60.6-1.30.60.40.3-0.60.7-0.6-0.10.2-0.00.80.0
Pavlov. Cond. latency score0.40.52.5-1.3-0.6-0.4-0.41.20.5-0.60.60.60.6-1.60.60.40.2-0.50.6-0.5-0.30.30.01.00.0
Pavlov. Cond. lever contacts0.60.72.6-1.4-0.6-0.8-0.81.40.8-0.90.90.90.9-1.60.90.80.6-0.80.9-0.90.1-0.1-0.30.70.0
Pavlov. Cond. magazine entry number0.20.21.20.9-0.00.40.4-1.1-0.50.5-0.5-0.5-0.50.7-0.5-0.4-0.30.6-0.50.5-0.00.00.5-0.10.0
Pavlov. Cond. intertrial magazine entries1.31.62.7-1.2-0.9-1.5-1.51.01.5-1.21.21.21.2-0.91.11.51.5-1.21.3-1.31.7-1.6-1.2-1.00.0
Pavlov. Cond. lever-magazine prob. diff.0.30.31.4-1.1-0.5-0.4-0.41.00.5-0.50.50.50.5-1.20.50.40.3-0.50.6-0.6-0.10.1-0.00.70.0
Pavlov. Cond. response bias0.30.41.6-0.90.1-0.6-0.61.30.7-0.60.60.60.6-0.70.60.60.4-0.70.8-0.70.2-0.2-0.7-0.10.0
Pavlov. Cond. lever latency0.30.52.11.31.50.50.5-0.6-0.50.5-0.5-0.5-0.51.2-0.5-0.6-0.50.6-0.50.5-0.0-0.0-0.3-1.10.0
Pavlov. Cond. magazine entry latency3.03.55.92.11.22.12.1-2.2-2.12.1-2.1-2.1-2.12.4-2.1-2.0-1.72.1-1.71.7-1.71.61.40.40.0
Pavlov. Cond. change in total contacts0.30.42.4-1.0-1.00.20.20.4-0.10.0-0.0-0.0-0.0-1.5-0.1-0.1-0.30.3-0.30.3-0.70.80.81.50.0
Pavlov. Cond. index score1.01.32.10.4-0.21.31.3-1.0-1.21.2-1.2-1.2-1.20.3-1.3-1.1-1.11.2-1.11.1-1.41.51.31.40.0
Pavlov. Cond. latency score1.31.62.30.6-0.01.41.4-1.1-1.41.4-1.4-1.4-1.40.5-1.4-1.3-1.31.4-1.31.3-1.51.51.41.30.0
Pavlov. Cond. lever contacts0.40.53.1-1.2-1.8-0.2-0.20.40.1-0.20.20.20.2-1.10.20.30.2-0.20.3-0.2-0.50.60.81.70.0
Pavlov. Cond. magazine entry number3.03.74.8-1.6-0.4-2.2-2.22.22.2-2.22.22.22.2-1.72.22.11.9-2.11.8-1.92.1-2.1-1.9-1.40.0
Pavlov. Cond. intertrial magazine entries3.34.35.7-2.2-1.8-2.4-2.42.02.3-2.32.32.32.3-2.22.32.22.2-2.42.1-2.12.1-2.0-1.3-0.40.0
Pavlov. Cond. lever-magazine prob. diff.1.01.32.30.4-0.21.31.3-0.9-1.21.2-1.2-1.2-1.20.3-1.3-1.1-1.11.2-1.01.1-1.51.51.31.40.0
Pavlov. Cond. response bias0.30.52.3-0.2-1.10.60.6-0.5-0.60.5-0.5-0.5-0.50.0-0.5-0.5-0.40.5-0.30.3-1.01.01.11.50.0
Time in closed arm before self-admin0.20.21.1-0.6-0.5-0.3-0.30.4-0.20.3-0.3-0.3-0.3-0.0-0.20.0-0.20.00.1-0.0-0.90.90.61.00.0
Time in closed arm after self-admin0.30.32.1-0.7-1.40.20.2-0.1-0.10.1-0.1-0.1-0.10.5-0.2-0.10.3-0.00.6-0.5-0.70.70.91.40.0
Time in open arm before self-admin2.12.33.40.81.51.81.8-1.1-1.61.8-1.8-1.8-1.80.6-1.8-1.4-1.81.9-1.71.7-1.51.50.90.20.0
Time in open arm after self-admin0.50.54.10.72.0-0.4-0.40.50.00.4-0.4-0.4-0.4-0.1-0.40.0-0.60.3-0.60.60.3-0.4-1.1-1.70.0
Bone: periosteal estimation1.02.04.4-2.1-1.4-1.5-1.51.51.5-1.61.61.61.6-1.41.61.61.6-1.71.7-1.71.0-0.9-0.50.50.0
Bone: periosteal perimeter0.71.23.7-1.7-1.9-1.1-1.10.70.9-1.11.11.11.1-1.21.11.01.1-1.11.1-1.10.3-0.20.31.40.0
Bone: post-yield work1.11.53.4-0.70.2-1.3-1.31.31.3-1.11.11.11.1-0.01.11.11.3-1.11.5-1.51.5-1.5-1.9-1.60.0
Progressive ratio test 1 active lever presses1.01.01.6-1.30.5-0.8-0.80.81.0-1.21.21.21.2-0.51.30.81.1-1.01.2-1.21.1-1.1-1.1-1.00.0
Progressive ratio test 1 breakpoint1.81.93.0-1.70.2-1.2-1.21.11.4-1.71.71.71.7-0.91.71.21.5-1.31.5-1.51.5-1.5-1.3-1.10.0
Progressive ratio test 1 inactive lever presses0.10.10.50.1-0.50.60.6-0.5-0.30.1-0.1-0.1-0.10.4-0.0-0.2-0.10.4-0.20.2-0.40.40.70.70.0
Progressive ratio test 2 active lever presses0.00.00.4-0.60.20.00.0-0.10.1-0.00.00.00.0-0.2-0.0-0.00.20.10.4-0.40.1-0.1-0.0-0.20.0
Progressive ratio test 2 breakpoint0.30.31.4-1.2-0.1-0.4-0.40.40.6-0.60.60.60.6-0.70.50.50.7-0.40.8-0.80.6-0.6-0.4-0.40.0
Progressive ratio test 2 inactive lever presses1.11.23.3-0.5-0.1-1.5-1.50.21.1-1.01.01.01.00.21.01.21.4-0.71.1-1.21.8-1.8-1.0-1.60.0
Incentive Sensitization - Responses0.10.10.9-0.9-0.90.20.2-0.20.10.0-0.0-0.0-0.0-0.5-0.10.00.30.10.4-0.3-0.00.10.50.70.0
Incentive Sensitization - Breakpoint0.10.10.7-0.9-0.90.10.1-0.20.10.0-0.0-0.0-0.0-0.4-0.10.10.40.00.4-0.40.1-0.00.50.60.0
Sum of active levers in priming session hrs 5-62.62.55.82.42.42.02.0-1.4-1.61.4-1.4-1.4-1.41.6-1.4-1.7-1.81.7-1.91.8-0.90.80.3-1.10.0
Progressive ratio0.40.41.9-0.61.20.00.01.10.4-0.60.60.60.6-1.00.60.2-0.1-0.20.2-0.20.3-0.4-1.2-1.40.0
Food seeking constrained by brief footshock0.10.10.30.30.60.30.3-0.5-0.30.2-0.2-0.2-0.2-0.0-0.1-0.3-0.20.5-0.00.0-0.00.00.1-0.50.0
Seeking ratio, punishment vs. effort0.10.21.00.6-0.3-0.0-0.0-0.9-0.20.4-0.4-0.4-0.41.0-0.2-0.10.30.20.2-0.10.0-0.00.60.40.0
Retroperitoneal fat weight4.514.827.24.00.24.54.5-5.2-4.43.9-3.9-3.9-3.94.3-3.9-4.1-3.34.0-3.53.5-3.93.94.42.80.0
Reaction time number correct0.20.31.2-1.1-0.9-0.7-0.70.60.5-0.50.50.50.5-1.00.50.70.4-0.70.3-0.30.2-0.20.10.70.0
Reaction time mean minus median1.21.62.91.71.71.51.5-1.2-1.21.6-1.6-1.6-1.61.3-1.6-1.2-1.21.1-1.11.1-0.80.80.5-0.40.0
Reaction time mean minus median AUC2.02.75.02.21.42.02.0-1.7-1.71.9-1.9-1.9-1.91.9-1.9-1.7-1.51.5-1.41.4-1.31.31.1-0.00.0
Reaction time num false alarms1.72.25.1-0.8-2.1-1.5-1.5-0.31.2-1.61.61.61.61.41.61.42.3-1.42.0-2.01.7-1.6-0.2-0.10.0
Reaction time num false alarms AUC2.02.86.0-0.8-1.6-1.7-1.70.11.6-1.81.81.81.81.31.91.62.4-1.62.3-2.32.0-2.0-0.8-0.80.0
Reaction time trials correct on left0.20.31.2-1.1-0.9-0.7-0.70.60.5-0.50.50.50.5-1.00.50.70.4-0.70.3-0.30.2-0.20.10.70.0
Reaction time trials on left0.20.31.1-1.1-0.9-0.7-0.70.60.5-0.40.40.40.4-0.90.40.60.4-0.70.3-0.30.2-0.10.10.70.0
Reaction time mean1.62.37.92.21.21.71.7-2.0-1.51.7-1.7-1.7-1.72.8-1.8-1.3-0.91.4-0.80.8-1.01.01.0-0.10.0
Reaction time mean AUC2.12.97.22.31.31.91.9-2.1-1.72.0-2.0-2.0-2.02.7-2.0-1.5-1.31.6-1.11.1-1.31.31.20.10.0
Median of all reaction times1.21.68.22.00.91.31.3-1.8-1.21.4-1.4-1.4-1.42.9-1.4-1.0-0.61.1-0.40.4-0.80.80.8-0.20.0
Reaction time omissions2.33.16.62.30.61.91.9-2.3-1.92.0-2.0-2.0-2.02.6-2.0-1.7-1.41.8-1.21.2-1.61.61.70.70.0
Reaction time false alarm rate1.01.43.2-0.0-1.1-1.0-1.0-0.40.9-1.21.21.21.21.71.20.91.8-0.91.7-1.71.5-1.4-0.5-0.80.0
Reaction time premature initiation rate0.20.30.60.70.40.30.3-0.8-0.70.5-0.5-0.5-0.50.7-0.5-0.6-0.50.6-0.40.4-0.60.60.40.30.0
Reaction time premature initiations0.00.10.4-0.1-0.2-0.2-0.2-0.3-0.20.1-0.1-0.1-0.1-0.0-0.1-0.1-0.10.1-0.10.1-0.30.40.40.60.0
Std. dev. reaction times1.52.15.32.01.51.71.7-1.6-1.41.7-1.7-1.7-1.72.3-1.7-1.3-1.11.3-0.80.8-1.01.00.8-0.30.0
Reaction time trials completed0.20.31.1-1.1-0.9-0.7-0.70.60.5-0.40.40.40.4-0.90.40.60.4-0.70.3-0.30.2-0.10.10.70.0
Reaction time trials AUC0.50.82.0-1.4-1.1-1.1-1.10.90.9-0.90.90.90.9-1.00.91.00.9-1.10.8-0.80.6-0.5-0.20.60.0
Run reversals in cocaine runway, females0.20.21.30.9-1.2-0.3-0.3-0.50.10.0-0.0-0.0-0.00.6-0.10.30.4-0.10.4-0.40.2-0.20.30.20.0
Run reversals in cocaine runway, males0.80.82.20.40.10.70.7-1.5-1.11.0-1.0-1.0-1.01.4-1.0-0.8-0.61.1-0.70.7-0.80.81.10.50.0
Latency to leave start box in cocaine runway1.11.23.70.2-1.11.01.0-1.1-1.01.1-1.1-1.1-1.10.8-1.1-1.1-0.60.9-0.40.5-1.41.51.61.90.0
Latency to leave start box in cocaine runway, F1.11.24.30.5-1.40.70.7-1.0-0.91.2-1.2-1.2-1.20.9-1.2-0.9-0.40.8-0.20.3-1.41.51.72.10.0
Latency to leave start box in cocaine runway, M0.10.10.3-0.2-0.10.60.6-0.1-0.30.2-0.2-0.2-0.20.0-0.2-0.4-0.20.2-0.10.1-0.40.40.10.10.0
Std. dev. time between licks in bursts1.31.52.5-1.6-0.7-1.2-1.21.11.3-1.51.51.51.5-1.41.51.31.3-1.31.2-1.21.1-1.1-0.70.00.0
Total sessions with >9 infusions0.70.89.00.43.00.00.00.3-0.1-0.00.00.00.0-0.3-0.0-0.4-0.50.1-0.40.30.5-0.6-1.3-2.30.0
Short access day 1 total inactive lever presses0.10.10.5-0.6-0.30.30.3-0.5-0.2-0.00.00.00.0-0.00.0-0.20.00.1-0.10.1-0.20.30.60.70.0
Short access day 10 total inactive lever presses0.30.32.2-0.3-1.5-0.1-0.10.40.3-0.50.50.50.5-0.30.50.50.3-0.30.3-0.3-0.20.20.31.20.0
Short access day 1 total infusions1.21.32.1-1.40.5-1.0-1.01.01.1-1.41.41.41.4-0.61.30.81.1-1.01.3-1.31.2-1.2-1.2-1.10.0
Short access day 10 total infusions2.62.95.5-1.20.8-1.7-1.71.21.7-1.81.81.81.8-0.31.71.41.8-1.71.9-1.92.2-2.2-2.1-2.40.0
Short access total infusions1.92.18.5-0.92.1-1.3-1.31.31.3-1.21.21.21.2-0.71.21.01.0-1.11.2-1.21.8-1.9-2.3-2.90.0
Short access day 1 locomotion0.20.21.40.70.40.20.2-0.20.1-0.50.50.50.51.20.50.10.4-0.20.5-0.50.2-0.2-0.3-0.40.0
Short access day 10 total locomotion0.10.21.30.51.20.20.2-0.3-0.40.1-0.1-0.1-0.10.6-0.1-0.3-0.40.4-0.40.4-0.30.30.1-0.50.0
Short access total locomotion0.40.54.11.02.00.20.2-0.3-0.2-0.10.10.10.11.20.1-0.3-0.20.2-0.20.20.3-0.3-0.6-1.60.0
One hour access (0.3 mA shock)0.10.20.6-0.3-0.5-0.3-0.3-0.00.5-0.30.30.30.30.10.30.40.7-0.20.7-0.70.6-0.6-0.1-0.10.0
Compulsive drug intake3.73.88.22.00.72.92.9-1.6-2.11.9-1.9-1.9-1.92.3-1.9-2.2-1.91.9-1.71.7-2.22.21.71.10.0
One hour access (shock baseline)1.21.42.7-1.4-1.0-1.6-1.60.71.3-1.11.11.11.1-1.11.11.41.5-1.11.3-1.31.5-1.5-0.7-0.30.0
Social response proportion2.12.33.01.60.91.61.6-1.5-1.71.6-1.6-1.6-1.61.6-1.6-1.6-1.71.7-1.61.6-1.71.71.30.70.0
Social responses0.50.71.6-0.7-1.3-0.9-0.90.10.7-1.01.01.01.0-0.01.00.91.1-0.51.0-1.00.7-0.60.30.40.0
Social time0.50.72.01.1-0.30.80.8-1.3-0.80.9-0.9-0.9-0.91.4-0.9-0.7-0.40.9-0.40.4-0.60.61.00.40.0
Soleus weight0.10.42.7-0.6-1.6-0.4-0.4-0.40.4-0.60.60.60.60.10.60.50.9-0.40.9-0.80.4-0.30.60.80.0
Bone: stiffness2.43.85.2-2.2-0.6-2.2-2.22.32.2-2.12.12.12.1-2.02.12.22.0-2.22.1-2.11.9-1.9-1.7-0.80.0
Tibialis anterior weight0.10.51.20.10.90.50.50.5-0.50.7-0.7-0.7-0.7-1.1-0.7-0.6-1.10.7-0.90.9-0.90.90.10.40.0
Time to tail flick, vehicle, before self-admin3.94.05.71.81.02.42.4-2.2-2.32.1-2.1-2.1-2.11.2-2.2-2.4-2.21.8-2.22.2-2.22.21.91.10.0
Time to tail flick, vehicle, after self-admin1.92.03.21.61.51.71.7-1.3-1.51.6-1.6-1.6-1.61.1-1.8-1.6-1.61.4-1.51.5-1.21.10.8-0.20.0
Time to tail flick, test, before self-admin0.40.43.6-0.2-1.90.50.5-0.9-0.1-0.30.30.30.3-0.20.2-0.20.4-0.20.0-0.0-0.10.11.21.50.0
Time to tail flick, test, after self-admin0.30.31.6-0.80.2-0.8-0.81.30.6-0.60.60.60.6-0.70.60.50.2-0.50.2-0.20.1-0.1-0.60.00.0
Delta time to tail flick, vehicle, before/after SA1.11.11.7-1.1-0.2-1.2-1.21.11.2-1.11.11.11.1-0.81.11.11.1-1.00.9-1.01.3-1.3-1.2-0.90.0
Delta time to tail flick, test, before/after SA0.30.32.0-0.21.4-0.4-0.41.1-0.10.3-0.3-0.3-0.3-0.1-0.30.0-0.70.4-0.40.4-0.60.6-0.6-0.30.0
Tibia length4.813.422.8-4.8-4.6-4.1-4.12.53.8-3.93.93.93.9-3.13.94.14.5-4.14.1-4.13.5-3.3-1.10.70.0
Ambulatory time before self-admin2.72.84.4-0.6-0.2-1.9-1.91.92.0-1.61.61.61.6-1.21.71.81.7-1.71.8-1.82.1-2.1-2.0-1.70.0
Ambulatory time after self-admin1.41.63.9-1.3-0.6-1.5-1.51.61.5-1.31.31.31.3-2.01.21.31.1-1.01.0-1.01.4-1.4-1.1-0.70.0
Bone: tissue strength1.51.52.3-1.3-0.9-1.3-1.30.91.3-1.41.41.41.4-0.61.41.31.5-1.31.4-1.41.2-1.2-0.8-0.20.0
Total heroin consumption1.21.46.61.62.61.41.4-0.7-1.00.9-0.9-0.9-0.91.7-1.0-1.1-1.31.1-1.21.1-0.50.4-0.4-1.60.0
Bone: trabecular number0.81.26.8-1.71.6-0.8-0.82.41.0-0.80.80.80.8-2.60.80.7-0.0-0.60.0-0.10.4-0.4-1.5-0.40.0
Bone: trabecular spacing1.82.311.52.2-0.91.21.2-3.1-1.61.3-1.3-1.3-1.33.4-1.3-1.2-0.41.2-0.60.6-0.70.82.00.60.0
Bone: trabecular thickness2.02.47.3-1.61.3-1.4-1.42.71.8-1.41.41.41.4-2.21.41.51.0-1.41.2-1.21.4-1.4-2.4-1.50.0
Bone: trabecular tissue density0.20.32.60.3-1.6-0.0-0.0-1.1-0.10.1-0.1-0.1-0.11.1-0.00.10.6-0.00.6-0.60.1-0.10.90.50.0
Water consumed over 24 hours0.20.21.4-0.8-0.5-0.3-0.30.80.4-0.30.30.30.3-1.20.30.30.1-0.40.1-0.10.1-0.1-0.30.00.0
Number of responses in last shaping day2.12.27.0-2.6-1.3-1.6-1.61.81.6-1.51.51.51.5-2.01.51.51.4-1.71.3-1.31.1-1.1-0.80.40.0