Hub : Genes

Tab1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Tab1 0.04 0.02 1.3e-04 0.01 0.01 0.01 0 2.3e-03 4.2e-02 3.4e-03 3.6e-01
2 Brain mRNA stability Tab1 0.04 0.03 3.2e-03 0.03 0.03 0.01 0.03 3.4e-04 2.1e-03 2.0e-02 5.0e-04
3 LHb gene expression Tab1 0.17 0.09 2.5e-03 0.07 0.11 0.07 0.1 7.6e-03 1.6e-03 1.2e-02 3.0e-03
4 pVTA mRNA stability Tab1 0.05 0.03 4.5e-04 0.02 0.03 0.04 0.03 6.5e-03 1.9e-03 7.3e-04 1.2e-03
5 pVTA gene expression Tab1 0.22 0.07 0.0e+00 0.23 0.25 0.25 0.25 1.1e-18 7.3e-20 5.3e-20 2.6e-20
6 NAcc gene expression Tab1 0.1 0.04 1.1e-16 0.09 0.11 0.11 0.11 7.0e-14 6.8e-17 7.9e-17 1.4e-16
7 PL gene expression Tab1 0.18 0.07 0.0e+00 0.17 0.18 0.18 0.18 1.9e-18 2.0e-19 1.1e-19 4.8e-19
8 Liver gene expression Tab1 0.11 0.05 2.4e-10 0.06 0.08 0.08 0.08 3.0e-07 2.3e-09 9.2e-09 6.0e-09
9 BLA gene expression Tab1 0.29 0.13 1.2e-08 0.14 0.1 0.12 0.14 4.2e-08 1.0e-05 4.4e-07 5.5e-08
10 OFC gene expression Tab1 0.42 0.17 1.0e-04 0.05 0.08 0.15 0.1 3.0e-02 5.0e-03 2.1e-04 2.1e-03
11 Brain gene expression Tab1 0.28 0.11 0.0e+00 0.26 0.24 0.25 0.18 1.8e-24 1.7e-22 9.6e-23 2.4e-16
12 IC gene expression Tab1 0.2 0.11 1.1e-05 0.17 0.12 0.15 0.16 1.5e-07 8.1e-06 5.3e-07 2.4e-07
13 Adipose gene expression Tab1 0.03 0.02 5.1e-03 0.03 0.01 0.01 0.02 4.6e-04 2.0e-02 1.7e-02 3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.60.40.60.30.60.30.50.3-0.20.50.70.70.5-0.0
Area under the delay curve2.02.34.31.20.92.11.81.81.91.90.51.51.71.31.40.8
BMI with tail0.62.14.3-2.1-1.5-1.9-1.4-1.9-1.5-1.9-0.1-1.3-0.7-1.2-1.3-0.9
BMI without tail0.10.41.3-0.70.1-1.1-0.4-0.6-0.6-0.6-0.70.0-0.20.10.1-1.1
Body weight1.14.910.0-2.9-2.5-2.8-3.2-2.5-2.2-2.31.1-2.2-0.8-1.9-2.2-0.2
Weight adjusted by age0.20.30.70.60.3-0.7-0.5-0.1-0.7-0.2-0.5-0.5-0.8-0.4-0.6-0.4
Bone surface0.20.30.80.80.20.60.20.60.70.70.40.30.90.40.30.4
Bone volume0.00.00.40.10.00.20.20.10.30.10.10.00.60.20.1-0.0
Breakpoint value in progressive ratio session0.10.10.3-0.4-0.30.3-0.1-0.00.3-0.00.40.20.50.20.40.4
Number of licking bursts0.61.02.01.41.21.01.01.41.01.4-0.40.90.10.91.0-0.4
Context. condit. distance diff. score6.68.012.3-2.9-2.6-3.5-3.0-3.2-3.3-3.2-0.2-3.1-2.5-3.1-3.1-1.4
Locomotion velocity, session 10.70.82.20.6-0.30.9-0.31.10.81.21.50.31.00.50.31.1
Locomotion distance, session 13.03.87.02.51.82.51.82.62.22.60.31.61.81.81.70.2
Locomotion velocity, session 20.10.20.8-0.3-0.90.2-0.2-0.30.1-0.20.7-0.30.4-0.2-0.20.4
Locomotion distance, session 24.76.610.92.31.93.32.53.03.13.10.92.62.92.62.61.5
Locomotion velocity, session 32.42.84.2-0.3-1.1-2.0-1.6-1.4-2.1-1.6-0.8-2.0-2.0-2.0-2.0-1.7
Locomotion distance, session 31.01.15.11.80.9-0.50.10.4-0.60.2-1.5-0.5-1.2-0.6-0.5-2.3
Stereotopy head waving bouts, day 30.60.72.4-1.3-1.30.0-0.8-0.20.2-0.11.6-0.00.90.0-0.21.4
Stereotopy head waving duration, day 32.02.47.2-2.7-2.6-0.9-1.8-1.3-0.7-1.12.0-1.00.4-0.9-1.11.5
Locomotion velocity, session 71.11.21.8-1.0-1.1-0.9-1.3-1.2-1.1-1.20.2-1.3-1.4-1.2-1.3-0.2
Locomotion distance, session 70.20.20.9-0.3-0.40.5-0.40.30.40.51.00.00.20.10.00.9
Stereotopy head waving bouts, day 74.04.56.4-1.5-2.0-2.5-2.3-2.5-2.5-2.5-0.3-2.3-1.9-2.4-2.5-1.3
Stereotopy head waving duration, day 73.94.77.8-1.5-1.9-2.6-1.9-2.8-2.5-2.8-0.7-2.2-2.0-2.3-2.3-1.5
Locomotion velocity, session 81.21.43.4-1.6-1.8-0.9-1.8-0.9-0.8-0.71.5-1.0-0.2-1.1-1.00.8
Locomotion distance, session 80.71.01.4-1.0-0.6-1.2-0.7-1.1-1.2-1.2-0.4-1.2-0.9-1.1-1.1-0.7
Degree of sensitization distance1.61.66.8-2.4-1.50.0-1.0-0.80.1-0.62.0-0.00.70.10.02.6
Degree of sensitization stereotypy3.33.65.4-1.2-1.6-2.3-1.9-2.3-2.3-2.2-0.5-2.1-1.8-2.1-2.1-1.4
Conditioned locomotion0.30.40.7-0.8-0.8-0.6-0.7-0.6-0.6-0.60.2-0.6-0.7-0.7-0.60.2
Cocaine response after cond. corrected0.20.21.1-0.1-0.70.4-0.30.10.30.20.9-0.10.50.2-0.11.1
Cocaine response after cond. not corrected0.10.10.5-0.1-0.30.3-0.1-0.10.2-0.10.4-0.10.40.1-0.10.7
Cocaine response before conditioning0.30.41.70.41.0-0.30.5-0.4-0.3-0.5-1.30.1-0.5-0.20.1-1.1
Saline control response0.60.72.50.50.3-1.1-0.4-0.8-1.0-0.9-1.2-0.5-1.6-0.7-0.6-0.7
Bone: connectivity density0.00.10.20.40.10.1-0.10.20.30.20.30.20.40.30.20.3
Bone: cortical apparent density0.71.04.61.40.7-0.80.3-0.0-0.8-0.1-1.7-0.3-1.3-0.5-0.3-2.1
Bone: cortical area0.60.92.9-1.7-1.50.0-0.6-0.50.1-0.31.7-0.31.1-0.3-0.41.4
Bone: cortical porosity0.50.61.6-1.2-0.6-0.3-0.6-1.3-0.4-1.20.4-0.4-0.4-0.3-0.41.1
Bone: cortical porosity1.31.43.5-1.9-1.5-0.4-1.3-1.5-0.5-1.31.3-0.8-0.1-0.6-0.81.8
Bone: cortical thickness0.20.31.0-0.7-0.40.60.50.30.60.30.80.21.00.30.20.8
Bone: cortical thickness1.21.44.1-0.6-0.11.40.91.21.41.31.40.92.00.90.91.0
Bone: cortical tissue density0.70.94.11.40.6-0.80.2-0.0-0.8-0.1-1.6-0.3-1.3-0.6-0.3-2.0
Condit. Reinf. active minus inactive responses0.10.10.40.30.20.30.20.60.40.60.10.30.60.40.40.0
Condit. Reinf. active-inactive response ratio0.40.40.7-0.5-0.5-0.8-0.6-0.5-0.8-0.6-0.2-0.8-0.5-0.7-0.8-0.5
Condit. Reinf. active responses0.70.91.71.31.10.51.10.90.70.8-1.01.00.61.01.1-0.7
Condit. Reinf. inactive responses1.31.64.12.01.80.51.61.00.80.8-1.61.40.31.21.5-1.1
Incentive salience index mean0.30.40.70.60.60.50.60.80.60.7-0.20.60.70.70.7-0.1
Condit. Reinf. lever presses0.20.30.50.60.60.40.70.60.50.5-0.50.60.50.70.6-0.4
Condit. Reinf. active minus inactive responses1.01.32.70.30.11.50.21.21.41.51.60.81.60.70.71.5
Condit. Reinf. active-inactive response ratio0.80.92.9-0.4-0.51.0-0.20.71.00.91.70.51.50.40.41.5
Condit. Reinf. active responses0.60.83.2-0.3-0.71.0-0.50.50.70.71.80.01.0-0.1-0.11.6
Condit. Reinf. inactive responses0.20.31.0-0.3-0.80.3-0.7-0.1-0.00.01.0-0.60.1-0.7-0.60.7
Condit. Reinf. lever presses0.50.71.01.00.91.00.80.80.90.80.00.80.80.90.80.7
Condit. Reinf. lever reinforcers received0.60.83.1-0.2-0.51.1-0.40.50.80.71.70.11.00.10.11.8
Conditioned reinforcement - actives0.61.12.40.5-0.01.50.41.21.21.41.40.71.50.60.41.1
Conditioned reinforcement - inactives3.14.67.40.81.02.71.62.62.72.71.52.42.52.42.21.4
Conditioned locomotion1.21.64.4-0.7-0.71.40.30.71.41.02.00.92.00.90.62.1
Patch foraging indifference point 0 sec0.30.61.30.40.90.50.80.60.80.6-0.11.10.61.11.20.7
Patch foraging indifference point AUC1.82.56.01.91.01.91.32.41.82.50.81.31.51.31.20.6
Delay disc. indifference point, 0s delay0.30.31.3-1.1-0.80.1-0.0-0.50.2-0.50.70.00.4-0.20.01.1
Delay disc. indifference point, 16s delay2.72.95.01.81.42.21.92.12.02.10.21.81.61.71.60.7
Delay disc. indifference point, 2s delay1.21.33.50.40.31.91.61.01.51.10.50.91.80.50.90.8
Delay disc. indifference point, 24s delay1.21.33.71.00.41.30.51.81.31.91.20.80.90.90.90.7
Delay disc. indifference point, 4s delay1.11.22.30.50.41.51.31.31.41.20.61.01.40.91.00.8
Delay disc. indifference point, 8s delay2.12.54.01.61.41.91.82.01.82.00.21.71.61.61.50.4
Indifference point function ln k2.23.97.0-1.8-1.5-2.4-1.8-2.6-2.3-2.6-0.6-2.1-1.9-2.0-2.0-0.8
Indifference point function log k2.23.97.0-1.8-1.5-2.4-1.8-2.6-2.3-2.6-0.6-2.1-1.9-2.0-2.0-0.8
Patch foraging total patch changes 0 sec0.51.01.90.61.20.71.30.81.00.8-0.31.40.81.31.40.5
Patch foraging total patch changes 12 sec0.40.62.10.30.01.00.50.60.90.70.80.60.80.40.61.5
Patch foraging total patch changes 18 sec2.03.04.60.41.01.91.11.82.12.01.41.92.12.01.81.9
Patch foraging total patch changes 24 sec0.50.91.50.71.01.21.01.21.21.20.21.00.71.11.00.4
Patch foraging total patch changes 6 sec2.63.95.81.21.42.01.82.32.42.41.02.32.22.22.41.3
Patch foraging time to switch 0 sec0.10.30.9-0.9-0.40.1-0.3-0.9-0.0-0.90.1-0.2-0.0-0.1-0.30.6
Patch foraging water rate 0 sec0.20.51.00.50.70.10.40.90.60.90.20.90.60.91.00.2
Patch foraging water rate 12 sec0.20.41.50.81.0-0.40.70.0-0.2-0.1-1.20.4-0.50.40.6-0.7
Patch foraging water rate 18 sec0.60.91.81.31.30.30.81.00.71.0-0.31.20.41.11.4-0.1
Patch foraging water rate 24 sec0.40.61.8-0.3-0.4-1.3-0.9-1.0-1.0-1.0-0.3-0.6-0.8-0.6-0.5-0.0
Patch foraging water rate 6 sec0.60.82.91.51.4-0.60.30.1-0.5-0.1-1.70.0-1.20.10.2-1.2
Seeking ratio, delayed vs. immediate footshock0.40.51.30.70.80.31.00.50.30.4-0.90.70.10.50.7-1.1
Distance traveled before self-admin0.81.02.30.20.61.51.40.81.30.80.11.11.41.20.80.9
Distance traveled after self-admin1.92.34.20.40.71.50.81.51.81.61.22.01.71.81.72.0
Extensor digitorum longus weight0.41.64.71.12.00.72.20.90.80.6-1.61.10.61.60.9-0.9
Bone: elastic displacement0.10.10.4-0.2-0.1-0.4-0.6-0.3-0.4-0.20.1-0.4-0.5-0.2-0.40.1
Bone: elastic work1.11.44.7-2.2-1.6-0.3-1.1-0.9-0.2-0.81.8-0.70.7-0.4-0.71.8
Bone: endosteal estimation0.51.03.0-1.3-1.6-0.1-1.2-0.60.0-0.41.7-0.30.8-0.4-0.31.7
Bone: endosteal perimeter0.92.04.6-2.0-2.1-0.9-1.8-1.5-0.9-1.41.5-1.30.0-1.2-1.31.1
Epididymis fat weight2.910.014.6-3.7-3.7-3.3-3.8-3.7-3.2-3.61.3-3.4-1.8-3.4-3.50.2
Delta time in closed arm before/after self-admin0.20.20.8-0.2-0.50.50.30.30.40.40.90.10.9-0.1-0.10.4
Delta time in open arm before/after self-admin0.20.20.80.50.60.40.40.50.40.5-0.30.90.20.60.4-0.1
Diff in mean of infusions in LGA sessions0.20.31.6-0.3-0.60.2-0.60.30.30.41.3-0.10.60.10.00.4
Delay discount exponential model param2.12.34.2-1.3-1.0-2.1-1.8-1.9-1.8-1.9-0.4-1.5-1.7-1.3-1.4-0.7
Extinction: sum of active levers before priming0.50.62.4-1.1-1.30.7-0.3-0.10.60.01.5-0.20.8-0.40.00.9
Active lever presses in extinction session 60.10.10.6-0.8-0.7-0.0-0.3-0.30.0-0.30.6-0.2-0.3-0.2-0.10.2
Bone: final force0.91.44.7-2.0-1.60.4-0.6-0.20.5-0.12.2-0.21.6-0.1-0.32.0
Bone: final moment1.01.65.4-1.9-1.60.4-0.6-0.10.60.12.3-0.11.80.0-0.22.1
Food consumed during 24 hour testing period0.50.73.1-1.2-1.30.1-0.8-0.30.2-0.11.8-0.20.6-0.2-0.21.3
Glucose0.10.10.4-0.4-0.1-0.1-0.6-0.6-0.1-0.60.10.0-0.00.0-0.00.6
Heart weight1.32.06.5-2.6-2.2-1.1-2.0-1.1-0.6-1.02.0-0.60.4-0.8-0.51.3
Delay discount hyperbolic model param1.92.14.0-1.2-0.9-2.0-1.8-1.7-1.8-1.7-0.4-1.3-1.7-1.1-1.3-0.6
Intermittent access intake day 1-15 change0.10.20.60.40.8-0.10.40.3-0.00.1-0.80.50.50.40.3-0.6
Intermittent access intake escalation0.20.31.00.71.0-0.10.50.4-0.00.2-1.00.50.40.30.4-0.8
Intermittent access intake escalation 20.30.30.90.61.0-0.10.50.40.10.3-0.80.70.20.50.6-0.7
Intermitt. access day 1 inactive lever presses0.20.73.6-0.8-0.50.6-0.40.10.60.21.30.60.80.60.41.9
Intermitt. access day 15 inactive lever presses0.71.42.20.20.71.40.61.41.41.40.81.51.41.41.30.9
Intermitt. access escalation Index0.30.41.10.80.90.10.80.30.10.2-1.10.3-0.30.40.4-1.0
Intermittent access day 1 total infusions1.22.04.6-0.3-0.72.00.41.21.71.42.20.92.10.90.61.8
Intermittent access day 15 total infusions1.01.53.90.70.61.61.11.51.41.50.51.22.01.10.90.6
Intermittent access terminal intake (last 3 days)1.01.33.10.60.41.61.01.41.41.50.71.21.81.00.80.6
Intermittent access total infusions2.42.96.30.0-0.22.41.01.82.11.92.01.52.51.41.21.7
Intermittent access day 1 locomotion1.62.04.1-0.10.11.81.01.31.81.41.41.52.01.51.21.6
Intermittent access day 15 total locomotion0.50.92.5-0.7-0.71.10.10.61.10.91.60.81.30.70.51.1
Intermittent access total locomotion1.41.64.4-0.6-0.61.40.11.11.51.32.11.21.71.10.91.7
Intermittent access standard deviation0.71.56.9-1.1-0.41.20.10.51.10.51.61.11.80.90.62.6
Left kidney weight5.525.749.0-6.9-7.0-4.0-6.9-5.3-4.0-4.74.5-5.1-1.4-5.1-5.22.5
Right kidney weight6.529.560.8-7.8-7.4-4.5-7.5-5.7-4.3-5.14.9-5.2-1.4-5.1-5.32.9
Cocaine induced anxiety0.81.12.8-1.6-1.7-0.9-1.3-1.0-0.7-0.91.2-1.1-0.2-1.1-0.80.1
Post-drug Anxiety0.60.61.5-0.4-0.6-1.2-1.0-0.7-1.0-0.7-0.1-0.9-0.7-0.9-0.8-0.7
Baseline Anxiety0.80.93.21.81.50.61.11.00.40.9-1.20.80.10.80.4-0.4
Tail length0.10.41.10.61.0-0.8-0.40.2-0.40.2-0.90.3-0.70.40.3-0.8
Length with tail0.62.56.9-1.3-1.3-2.2-2.6-1.5-1.8-1.40.6-1.7-1.2-1.4-1.7-0.1
Length without tail1.44.49.0-2.9-2.8-1.8-3.0-2.1-1.6-1.82.3-1.9-0.4-1.8-2.11.5
Times rat made contact with spout0.30.31.0-0.00.10.30.11.00.51.00.70.50.60.40.50.1
Lifetime Intake2.53.16.9-0.5-0.82.50.71.52.11.72.61.32.61.11.02.2
Liver weight, left1.72.94.8-1.1-1.4-1.8-1.8-1.6-2.0-1.6-0.4-2.0-2.0-2.1-2.2-1.2
Liver weight, right5.59.615.3-1.9-2.2-3.9-3.2-3.5-3.9-3.5-1.2-3.2-3.6-3.3-3.4-2.2
Locomotor activity0.81.32.3-1.4-1.3-1.4-1.5-1.2-1.1-1.20.8-1.0-0.4-1.0-1.20.2
Locomotor testing distance0.10.10.30.50.5-0.20.20.2-0.00.1-0.40.2-0.10.30.0-0.5
Locomotor testing rearing0.61.11.8-1.1-1.4-1.0-1.2-1.2-1.0-1.20.7-1.1-0.6-1.1-1.30.4
Locomotion in novel chamber1.31.76.62.02.0-0.41.10.3-0.30.0-2.60.4-1.20.40.3-2.1
Locomotion in novel chamber post-restriction0.30.41.40.90.90.41.20.10.20.1-1.10.3-0.10.20.1-1.0
Fecal boli incidents, locomotor time 11.52.23.50.70.31.70.81.81.81.91.41.71.61.51.61.6
Change in fecal boli incidents, locomotor task1.71.63.3-0.2-1.1-1.5-1.8-0.8-1.6-0.80.1-1.8-1.2-1.7-1.6-0.8
Time >=10cm from walls, locomotor time 10.50.52.1-0.9-1.1-0.1-0.8-0.3-0.0-0.11.4-0.20.4-0.2-0.31.4
Bouts of movement, locomotor time 11.01.12.1-1.2-1.3-0.8-1.4-0.9-0.9-0.80.9-1.3-1.1-1.2-1.20.1
Total resting periods, locomotor time 10.50.51.3-1.1-1.0-0.3-1.0-0.4-0.3-0.31.1-0.8-0.5-0.5-0.80.6
Rest time, locomotor task time 10.50.62.3-1.0-1.00.1-1.0-0.20.0-0.11.5-0.40.6-0.1-0.61.2
Distance moved, locomotor task time 10.60.81.5-0.4-0.2-1.2-0.3-1.1-1.1-1.2-1.0-0.9-0.9-0.9-0.8-1.0
Vertical activity count, locomotor time 10.10.20.50.10.3-0.7-0.2-0.1-0.2-0.2-0.40.2-0.70.00.4-0.6
Time >=10cm from walls, locomotor time 20.10.10.30.1-0.00.0-0.40.30.20.20.40.2-0.10.30.40.6
Bouts of movement, locomotor time 20.40.61.1-1.0-0.7-0.4-0.1-1.0-0.7-1.0-0.3-0.8-1.0-0.9-0.8-0.6
Total resting periods, locomotor time 20.10.20.7-0.8-0.60.10.1-0.6-0.2-0.60.1-0.4-0.4-0.6-0.5-0.3
Rest time, locomotor task time 20.40.51.70.40.20.80.00.80.60.80.90.31.30.60.10.8
Distance moved, locomotor task time 20.81.01.8-0.9-0.5-1.3-0.7-1.3-1.2-1.3-0.7-1.0-0.9-1.0-1.1-0.4
Vertical activity count, locomotor time 20.10.20.7-0.5-0.3-0.7-0.8-0.4-0.4-0.40.1-0.2-0.3-0.3-0.0-0.0
Light reinforcement 10.10.20.50.40.20.50.70.50.60.40.10.50.60.50.60.2
Light reinforcement 21.42.24.0-1.3-1.3-1.5-0.8-2.0-1.6-2.0-0.7-1.6-1.3-1.7-1.7-1.0
Bone: marrow area0.51.13.4-1.3-1.6-0.0-1.2-0.60.1-0.41.8-0.30.9-0.4-0.31.7
Bone: maximum diameter1.62.97.8-2.7-2.8-0.7-1.9-1.3-0.5-1.12.6-1.11.0-1.1-1.12.0
Bone: maximum force1.32.48.9-2.2-1.90.7-0.80.10.90.33.00.02.20.2-0.12.6
Bone: maximum moment1.52.59.8-2.2-2.00.7-0.80.10.90.33.10.02.30.2-0.02.7
Mean time between licks in bursts0.30.72.30.71.00.51.50.60.50.5-1.20.80.10.90.9-0.7
Mean num. licks in bursts0.71.12.1-1.4-1.5-1.1-1.4-1.0-1.0-0.90.8-1.0-0.2-1.1-1.10.3
Cd content in liver0.30.30.7-0.2-0.8-0.7-0.60.1-0.50.20.6-0.50.0-0.7-0.6-0.6
Co content in liver1.21.42.60.50.81.21.11.61.41.60.61.40.91.41.50.6
Cu content in liver4.45.28.82.83.02.03.02.32.22.1-1.62.31.62.52.4-1.0
Fe content in liver0.60.71.9-1.2-1.4-0.8-1.3-0.8-0.2-0.71.2-0.00.4-0.1-0.11.2
K content in liver0.40.41.91.21.40.50.30.40.40.3-0.80.4-0.10.50.5-0.1
Mg content in liver0.50.51.21.10.90.70.30.50.70.5-0.20.90.60.70.90.2
Mn content in liver0.30.30.50.40.1-0.4-0.4-0.5-0.7-0.5-0.6-0.6-0.5-0.7-0.7-0.7
Na content in liver0.70.81.71.31.30.50.60.80.70.7-0.71.10.31.01.1-0.3
Rb content in liver0.70.81.40.1-0.01.10.70.91.21.01.10.71.10.80.80.9
Se content in liver0.60.83.31.00.8-0.90.4-0.2-0.7-0.4-1.7-0.50.1-0.2-0.4-1.8
Sr content in liver2.01.74.21.51.90.72.01.10.70.9-1.91.00.61.11.0-1.5
Zn content in liver0.10.10.20.50.5-0.0-0.00.30.00.2-0.2-0.30.40.1-0.2-0.4
Bone: minimum diameter0.40.72.3-1.2-1.10.2-0.7-0.50.2-0.31.5-0.20.8-0.2-0.21.4
Time in familiar zone, hab. session 10.30.31.00.1-0.30.7-0.20.80.60.91.00.20.90.20.20.4
Time in novel zone, hab. session 10.50.51.3-0.6-0.2-1.1-0.4-1.1-0.9-1.1-0.5-0.3-1.0-0.4-0.3-0.2
Total zone transitions, hab. session 11.62.27.62.82.30.61.41.50.51.3-1.90.8-0.20.80.7-2.0
Total locomotion distance, hab. session 10.71.03.71.91.5-0.10.30.7-0.30.5-1.6-0.0-1.1-0.0-0.1-1.7
Locomotion velocity, hab. session 10.71.04.12.01.70.40.71.00.20.9-1.40.3-0.40.40.3-1.4
Time in familiar zone, hab. session 20.70.72.10.40.3-0.9-0.1-0.5-0.9-0.6-1.3-0.8-1.2-0.8-0.7-1.5
Time in novel zone, hab. session 20.80.82.5-0.3-0.10.80.10.60.90.71.30.91.10.80.81.6
Total zone transitions, hab. session 22.12.75.01.71.11.91.22.21.92.20.71.61.91.71.70.5
Total locomotion distance, hab. session 21.72.33.31.41.31.81.31.81.81.80.41.61.51.71.61.0
Locomotion velocity, hab. session 22.43.24.61.81.62.11.62.12.12.10.31.91.72.01.91.0
Novel to familiar place preference ratio1.01.13.0-1.2-0.9-1.7-1.3-1.0-1.3-0.90.2-0.9-0.6-1.0-0.9-0.8
Novelty place preference1.71.84.6-1.4-1.2-2.1-1.7-1.3-1.7-1.20.1-1.2-1.0-1.4-1.3-1.0
Time in novel zone, NPP test2.02.25.4-1.6-1.4-2.3-1.8-1.4-1.8-1.30.2-1.4-0.9-1.5-1.4-1.1
Total zone transitions, NPP test2.13.19.63.12.41.51.62.31.42.2-1.11.40.61.51.4-0.8
Total locomotion distance, NPP test1.11.53.31.81.61.41.01.71.21.7-0.21.10.61.11.00.2
Locomotion velocity, NPP test1.31.94.62.21.91.51.41.71.31.6-0.61.20.51.31.1-0.0
Intraocular pressure0.81.22.4-0.8-1.4-0.7-1.5-1.0-0.9-0.90.7-1.5-0.8-1.3-1.40.3
Delta distance traveled before/after self-admin0.40.41.6-0.3-0.6-0.6-1.30.1-0.20.21.30.0-0.1-0.20.11.0
Delta ambulatory time before/after self-admin0.40.52.4-0.2-0.6-0.3-1.10.30.10.51.60.10.3-0.00.21.4
Parametrial fat weight0.61.43.6-0.20.4-1.7-0.8-1.0-1.5-1.1-1.3-0.9-1.9-0.8-0.9-1.4
Pavlov. Cond. lever latency0.00.10.2-0.3-0.3-0.3-0.3-0.1-0.2-0.10.4-0.20.0-0.2-0.2-0.1
Pavlov. Cond. magazine entry latency0.60.81.70.30.61.31.01.01.11.00.10.90.90.90.90.6
Pavlov. Cond. change in total contacts2.12.23.90.70.82.01.61.71.91.70.41.61.71.51.71.0
Pavlov. Cond. index score0.30.41.00.10.21.00.50.70.90.70.40.60.70.60.60.8
Pavlov. Cond. latency score0.20.20.50.10.30.70.50.50.60.50.10.50.50.50.50.6
Pavlov. Cond. lever contacts0.50.60.90.80.90.91.00.70.80.6-0.50.80.30.80.80.3
Pavlov. Cond. magazine entry number0.70.81.9-0.4-0.6-1.4-1.0-1.2-1.1-1.1-0.2-0.8-0.9-0.9-0.8-0.5
Pavlov. Cond. intertrial magazine entries1.51.83.61.91.10.91.11.61.31.60.11.61.31.51.60.0
Pavlov. Cond. lever-magazine prob. diff.0.30.30.90.20.31.00.60.70.80.60.20.50.60.50.50.6
Pavlov. Cond. response bias0.50.61.60.30.51.30.90.91.00.80.10.70.80.70.70.6
Pavlov. Cond. lever latency0.50.71.3-1.0-1.2-0.7-0.8-0.4-0.8-0.40.3-1.0-0.4-1.0-1.0-0.7
Pavlov. Cond. magazine entry latency3.13.75.51.61.82.12.02.02.32.00.32.31.92.22.31.2
Pavlov. Cond. change in total contacts1.32.07.70.20.11.40.20.91.61.01.71.51.71.41.42.8
Pavlov. Cond. index score1.52.02.81.41.61.51.21.31.61.30.21.71.21.71.71.3
Pavlov. Cond. latency score1.92.53.51.61.81.71.41.61.81.50.11.81.31.81.91.3
Pavlov. Cond. lever contacts0.60.81.71.21.30.70.80.50.90.4-0.41.10.41.11.10.7
Pavlov. Cond. magazine entry number1.11.42.2-1.1-1.3-1.2-1.1-1.2-1.4-1.2-0.1-1.4-1.0-1.3-1.5-0.9
Pavlov. Cond. intertrial magazine entries0.40.61.8-1.3-1.2-0.1-0.9-0.3-0.2-0.11.3-0.50.4-0.6-0.50.7
Pavlov. Cond. lever-magazine prob. diff.1.41.82.71.31.61.41.31.21.51.10.01.61.21.61.71.2
Pavlov. Cond. response bias1.01.42.21.21.21.31.10.91.40.90.21.51.11.51.51.3
Time in closed arm before self-admin2.33.06.21.52.21.32.21.51.71.3-1.02.30.92.32.50.3
Time in closed arm after self-admin0.10.20.4-0.3-0.20.20.30.20.40.30.60.50.50.40.30.6
Time in open arm before self-admin0.40.51.30.1-0.2-0.7-0.6-0.4-0.9-0.4-0.5-1.2-0.5-0.8-0.9-0.7
Time in open arm after self-admin0.40.41.90.70.7-0.40.1-0.0-0.4-0.1-1.3-0.1-0.8-0.2-0.1-1.4
Bone: periosteal estimation0.71.64.6-1.9-2.1-0.1-1.2-0.80.0-0.62.1-0.51.2-0.5-0.51.9
Bone: periosteal perimeter1.93.37.8-2.7-2.8-1.1-2.3-1.8-1.0-1.62.1-1.60.2-1.4-1.61.7
Bone: post-yield work1.32.05.6-0.1-0.51.50.21.51.61.72.31.02.41.11.01.3
Progressive ratio test 1 active lever presses1.82.25.90.0-0.52.10.81.41.81.62.01.12.41.10.81.8
Progressive ratio test 1 breakpoint1.72.15.20.2-0.42.00.81.41.81.61.81.02.31.10.81.6
Progressive ratio test 1 inactive lever presses2.53.67.2-0.10.02.61.31.52.41.81.91.92.72.01.62.4
Progressive ratio test 2 active lever presses1.51.84.00.2-0.42.00.51.41.71.62.00.91.70.80.91.5
Progressive ratio test 2 breakpoint1.51.74.10.3-0.32.00.51.41.71.61.90.91.70.70.81.5
Progressive ratio test 2 inactive lever presses1.32.14.31.00.92.11.31.71.81.80.61.61.31.51.40.4
Incentive Sensitization - Responses0.10.20.50.60.40.70.10.50.40.60.20.2-0.20.20.30.1
Incentive Sensitization - Breakpoint0.10.10.40.40.20.6-0.00.40.40.60.40.2-0.20.10.20.2
Sum of active levers in priming session hrs 5-60.00.00.0-0.10.1-0.1-0.0-0.00.0-0.1-0.10.20.00.20.2-0.2
Progressive ratio0.20.40.7-0.10.20.60.30.70.70.70.50.80.80.90.60.6
Food seeking constrained by brief footshock0.30.31.2-0.9-1.10.2-0.2-0.20.1-0.11.1-0.40.7-0.4-0.40.4
Seeking ratio, punishment vs. effort0.10.20.7-0.6-0.8-0.1-0.3-0.5-0.2-0.40.6-0.50.1-0.6-0.40.3
Retroperitoneal fat weight3.715.622.5-4.7-4.7-4.0-4.7-4.6-3.9-4.31.8-4.3-2.2-4.4-4.40.3
Reaction time number correct0.61.13.11.00.8-0.7-0.1-0.5-0.9-0.6-1.7-0.9-1.8-0.9-0.6-1.7
Reaction time mean minus median0.00.00.1-0.20.3-0.00.00.00.0-0.1-0.20.30.0-0.00.30.3
Reaction time mean minus median AUC0.20.61.1-1.0-0.5-0.8-0.9-0.9-0.9-1.0-0.1-0.6-0.8-0.8-0.60.1
Reaction time num false alarms0.10.10.4-0.20.5-0.5-0.1-0.2-0.4-0.3-0.60.0-0.60.0-0.1-0.5
Reaction time num false alarms AUC0.10.20.60.10.6-0.5-0.1-0.1-0.4-0.3-0.8-0.1-0.7-0.1-0.2-0.7
Reaction time trials correct on left0.61.13.11.00.8-0.7-0.1-0.5-0.9-0.6-1.7-0.9-1.8-0.9-0.6-1.7
Reaction time trials on left0.61.13.11.00.8-0.6-0.0-0.4-0.9-0.6-1.8-0.9-1.8-0.9-0.6-1.8
Reaction time mean0.00.00.1-0.00.2-0.10.1-0.1-0.1-0.3-0.30.2-0.10.10.30.3
Reaction time mean AUC0.00.00.1-0.10.1-0.10.0-0.1-0.1-0.3-0.30.1-0.1-0.10.10.2
Median of all reaction times0.00.00.10.00.2-0.00.2-0.1-0.0-0.3-0.40.2-0.00.10.20.3
Reaction time omissions0.20.20.60.70.60.70.60.50.40.5-0.60.20.10.30.4-0.2
Reaction time false alarm rate0.00.00.1-0.40.1-0.3-0.0-0.1-0.1-0.1-0.10.30.10.30.0-0.0
Reaction time premature initiation rate0.81.24.3-0.2-0.11.20.30.71.30.71.41.11.31.00.92.1
Reaction time premature initiations0.10.21.40.10.20.7-0.10.30.60.20.60.40.30.30.41.2
Std. dev. reaction times0.10.20.5-0.5-0.2-0.6-0.7-0.4-0.5-0.5-0.0-0.2-0.4-0.4-0.20.3
Reaction time trials completed0.61.13.11.00.8-0.6-0.0-0.4-0.9-0.6-1.8-0.9-1.8-0.9-0.6-1.8
Reaction time trials AUC0.51.03.00.80.5-0.7-0.3-0.6-1.0-0.7-1.5-1.0-1.7-1.0-0.7-1.6
Run reversals in cocaine runway, females0.30.31.10.50.5-0.6-0.3-0.1-0.6-0.2-0.7-0.1-1.1-0.3-0.0-0.6
Run reversals in cocaine runway, males0.50.61.6-0.5-1.0-0.3-0.90.0-0.50.21.1-1.10.2-0.8-1.30.2
Latency to leave start box in cocaine runway1.01.22.8-1.0-0.8-1.0-0.7-1.7-1.2-1.5-0.3-1.3-0.8-1.2-1.2-0.3
Latency to leave start box in cocaine runway, F0.10.10.3-0.1-0.10.00.2-0.6-0.2-0.4-0.2-0.30.1-0.3-0.2-0.1
Latency to leave start box in cocaine runway, M2.62.44.1-1.4-1.0-1.7-1.5-2.0-1.8-2.0-0.4-1.8-1.7-1.7-1.7-0.5
Std. dev. time between licks in bursts1.01.32.20.91.01.11.21.31.31.3-0.11.40.81.51.50.4
Total sessions with >9 infusions1.92.39.1-2.0-2.31.1-0.7-0.10.80.23.0-0.11.7-0.1-0.32.5
Short access day 1 total inactive lever presses3.74.99.3-0.4-0.32.30.72.12.72.32.92.22.82.22.33.1
Short access day 10 total inactive lever presses0.10.31.1-0.6-0.7-0.4-1.1-0.2-0.2-0.10.9-0.10.1-0.2-0.10.6
Short access day 1 total infusions1.01.33.8-1.0-0.71.3-0.00.71.20.81.90.91.30.80.71.9
Short access day 10 total infusions1.21.65.2-1.5-1.61.1-0.30.10.90.32.30.21.90.10.02.2
Short access total infusions2.12.69.3-1.6-1.71.8-0.10.61.60.93.10.72.20.50.52.6
Short access day 1 locomotion0.60.72.6-0.4-0.20.90.20.50.90.51.00.81.00.80.71.6
Short access day 10 total locomotion0.91.73.80.10.81.50.90.91.41.00.51.71.61.71.31.9
Short access total locomotion1.01.15.0-0.9-0.61.10.20.31.00.41.40.81.50.90.52.2
One hour access (0.3 mA shock)2.22.65.30.80.82.32.01.82.01.80.51.72.31.51.30.3
Compulsive drug intake0.60.73.11.80.70.60.41.30.61.30.00.40.10.40.5-0.9
One hour access (shock baseline)0.40.61.7-0.40.21.21.20.41.00.40.20.91.30.70.60.6
Social response proportion0.20.20.5-0.70.10.00.6-0.40.2-0.5-0.10.40.50.50.60.7
Social responses0.60.81.10.90.61.11.01.01.01.00.30.90.91.00.90.9
Social time2.33.15.01.72.02.12.21.81.91.7-0.42.01.42.11.90.9
Soleus weight0.41.22.71.20.81.30.41.71.21.70.80.80.71.00.91.0
Bone: stiffness0.91.44.5-1.9-1.40.4-0.5-0.20.6-0.02.10.31.80.30.12.0
Tibialis anterior weight1.44.810.01.92.72.33.22.42.32.2-1.02.31.72.62.1-0.2
Time to tail flick, vehicle, before self-admin0.20.20.5-0.1-0.10.3-0.00.50.50.50.60.40.70.40.50.7
Time to tail flick, vehicle, after self-admin0.40.51.11.01.1-0.00.50.80.30.7-0.40.8-0.60.90.8-0.2
Time to tail flick, test, before self-admin0.40.41.0-0.4-0.6-0.3-0.2-0.7-0.7-0.5-0.1-1.0-0.7-0.8-0.9-0.1
Time to tail flick, test, after self-admin0.30.31.00.70.7-0.00.60.30.00.3-0.80.3-0.60.30.5-1.0
Delta time to tail flick, vehicle, before/after SA0.20.20.40.20.30.40.50.40.50.40.20.60.00.70.50.5
Delta time to tail flick, test, before/after SA1.61.63.51.81.90.31.31.10.70.9-1.51.3-0.41.31.5-1.5
Tibia length0.51.34.0-1.3-1.9-0.1-1.5-0.4-0.2-0.12.0-0.90.8-0.8-1.01.2
Ambulatory time before self-admin0.60.91.80.60.91.31.30.91.00.8-0.41.20.81.10.70.2
Ambulatory time after self-admin1.82.23.81.31.31.31.11.81.61.80.42.01.11.81.81.1
Bone: tissue strength0.40.40.9-0.2-0.8-0.6-1.0-0.7-0.6-0.60.4-0.9-0.4-0.8-0.80.2
Total heroin consumption0.30.41.4-0.2-0.50.80.10.60.80.61.20.01.00.10.30.6
Bone: trabecular number0.20.40.70.1-0.2-0.7-0.5-0.6-0.7-0.6-0.5-0.8-0.8-0.6-0.8-0.8
Bone: trabecular spacing0.91.25.5-0.9-1.20.7-0.60.40.70.62.30.21.40.20.22.0
Bone: trabecular thickness0.40.52.0-0.10.4-0.70.4-0.8-0.6-0.9-1.4-0.2-0.7-0.2-0.2-1.2
Bone: trabecular tissue density1.11.63.61.21.90.31.70.80.80.7-1.51.70.51.41.7-1.0
Water consumed over 24 hours0.40.51.20.30.30.50.21.00.71.11.00.80.70.70.70.7
Number of responses in last shaping day3.23.57.60.10.72.61.81.32.41.41.12.02.82.12.02.2