Hub : Genes

Syt5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Syt5 0.23 0.14 0.0e+00 0.2 0.23 0.22 0.22 2.3e-21 2.5e-24 3.6e-24 8.3e-24
2 IC mRNA stability Syt5 0.22 0.17 1.7e-05 0.04 0.05 0.04 0.04 6.5e-03 2.9e-03 5.5e-03 6.5e-03
3 BLA mRNA stability Syt5 0.22 0.13 1.4e-09 0.1 0.12 0.11 0.11 4.8e-06 1.0e-06 1.3e-06 2.3e-06
4 RMTg mRNA stability Syt5 0.1 0.07 7.8e-03 0.01 0.04 0 0.02 1.3e-01 3.2e-02 3.0e-01 1.2e-01
5 IL mRNA stability Syt5 0.28 0.16 1.2e-05 0.22 0.19 0.22 0.2 6.6e-06 2.8e-05 4.9e-06 1.4e-05
6 OFC mRNA stability Syt5 0.31 0.17 6.6e-05 0.2 0.06 0.09 0.12 2.1e-05 1.3e-02 3.8e-03 1.1e-03
7 NAcc mRNA stability Syt5 0.4 0.23 0.0e+00 0.32 0.33 0.33 0.31 3.1e-49 8.1e-51 1.9e-51 1.3e-48
8 OFC gene expression Syt5 0.64 0.17 1.0e-11 0.13 0.22 0.2 0.21 6.2e-04 7.5e-06 1.9e-05 1.0e-05
9 pVTA mRNA stability Syt5 0.14 0.08 2.1e-07 0.03 0.05 0.04 0.04 1.6e-03 1.1e-04 1.5e-04 1.6e-04
10 LHb mRNA stability Syt5 0.38 0.17 7.8e-08 0.29 0.29 0.28 0.3 1.3e-07 1.4e-07 2.5e-07 8.2e-08
11 Brain mRNA stability Syt5 0.22 0.12 0.0e+00 0.22 0.26 0.25 0.26 6.7e-20 2.3e-24 1.9e-23 1.3e-24
12 IL gene expression Syt5 0.63 0.16 1.8e-15 0.32 0.42 0.41 0.43 2.4e-08 1.9e-11 4.8e-11 1.6e-11
13 PL gene expression Syt5 0.47 0.17 0.0e+00 0.42 0.42 0.42 0.41 9.6e-50 3.5e-49 1.7e-49 1.2e-48
14 RMTg gene expression Syt5 0.13 0.09 2.9e-03 0.07 0.09 0.06 0.1 5.7e-03 2.2e-03 1.2e-02 1.1e-03
15 BLA gene expression Syt5 0.52 0.18 0.0e+00 0.32 0.31 0.32 0.32 1.0e-17 5.1e-17 3.2e-17 1.5e-17
16 Brain gene expression Syt5 0.48 0.18 0.0e+00 0.38 0.41 0.42 0.43 4.1e-37 9.3e-41 8.8e-42 2.2e-43
17 LHb gene expression Syt5 0.61 0.25 1.1e-10 0.33 0.3 0.37 0.34 1.1e-08 7.7e-08 1.0e-09 8.4e-09
18 NAcc gene expression Syt5 0.37 0.13 0.0e+00 0.36 0.36 0.37 0.37 2.2e-56 3.9e-58 2.5e-59 1.6e-58
19 IC gene expression Syt5 0.55 0.15 0.0e+00 0.36 0.36 0.35 0.36 6.3e-16 4.4e-16 1.6e-15 9.3e-16
20 pVTA gene expression Syt5 0.43 0.16 0.0e+00 0.16 0.22 0.19 0.18 6.7e-13 1.2e-17 2.8e-15 8.5e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.10.20.3-0.3-0.4-0.4-0.30.40.50.4-0.4-0.4-0.4-0.5-0.40.4-0.40.4-0.40.40.4-0.4-0.4
Area under the delay curve0.30.40.70.60.60.60.6-0.8-0.7-0.70.60.60.70.70.6-0.60.6-0.60.6-0.5-0.60.50.4
BMI with tail0.62.12.31.41.41.41.4-1.5-1.5-1.51.41.41.51.51.5-1.41.5-1.51.5-1.5-1.41.41.3
BMI without tail0.00.10.4-0.3-0.3-0.3-0.30.60.60.2-0.1-0.1-0.4-0.4-0.20.1-0.00.1-0.10.2-0.00.20.3
Body weight0.83.35.4-2.2-2.2-2.2-2.22.32.11.9-1.9-1.9-1.9-1.9-1.71.8-1.61.5-1.51.41.3-1.0-1.0
Weight adjusted by age0.41.21.9-1.0-1.0-1.0-1.00.70.81.1-1.1-1.1-0.9-1.0-1.11.3-1.21.2-1.20.91.4-1.3-1.3
Bone surface2.44.76.4-2.4-2.4-2.4-2.42.52.32.3-2.2-2.2-2.3-2.3-2.22.1-2.12.1-2.11.81.9-1.6-1.5
Bone volume1.93.84.9-2.1-2.1-2.1-2.12.22.22.0-2.0-2.0-2.1-2.1-2.01.9-1.91.9-1.91.71.7-1.5-1.4
Breakpoint value in progressive ratio session0.20.40.70.70.70.70.7-0.5-0.8-0.60.60.60.80.80.7-0.60.6-0.70.7-0.8-0.50.50.5
Number of licking bursts0.00.10.10.30.30.30.3-0.2-0.1-0.30.30.20.20.20.2-0.20.2-0.20.2-0.2-0.20.20.2
Context. condit. distance diff. score0.00.00.10.20.20.20.2-0.3-0.4-0.10.10.10.30.20.10.0-0.00.0-0.0-0.30.2-0.2-0.2
Locomotion velocity, session 10.70.83.2-0.2-0.2-0.2-0.2-0.40.10.5-0.7-0.7-0.3-0.4-0.71.0-1.01.0-1.11.21.3-1.7-1.8
Locomotion distance, session 13.34.35.9-1.8-1.8-1.8-1.81.61.62.0-2.1-2.1-1.9-1.9-2.12.2-2.22.2-2.22.32.3-2.4-2.4
Locomotion velocity, session 20.10.10.70.10.10.10.1-0.4-0.20.0-0.1-0.10.10.0-0.10.3-0.30.3-0.30.30.5-0.8-0.8
Locomotion distance, session 22.43.34.5-1.7-1.7-1.7-1.71.51.81.8-1.8-1.8-1.8-1.9-1.81.9-1.91.9-1.92.11.9-1.9-1.9
Locomotion velocity, session 30.00.00.00.20.20.20.2-0.2-0.2-0.10.10.10.10.10.10.0-0.00.0-0.0-0.10.1-0.1-0.2
Locomotion distance, session 30.40.40.9-0.5-0.5-0.5-0.50.40.30.6-0.6-0.7-0.5-0.5-0.60.7-0.70.7-0.70.60.8-0.9-0.9
Stereotopy head waving bouts, day 30.10.20.20.40.40.40.4-0.2-0.4-0.40.40.40.40.40.4-0.50.5-0.50.4-0.2-0.40.40.4
Stereotopy head waving duration, day 30.20.20.30.40.40.40.4-0.2-0.3-0.40.40.40.40.40.5-0.50.5-0.50.5-0.4-0.50.50.5
Locomotion velocity, session 70.20.20.4-0.2-0.2-0.2-0.20.20.10.4-0.4-0.4-0.2-0.3-0.40.5-0.50.5-0.50.40.6-0.6-0.6
Locomotion distance, session 70.10.20.6-0.2-0.2-0.2-0.2-0.2-0.10.3-0.3-0.3-0.1-0.2-0.40.5-0.50.5-0.50.30.7-0.7-0.8
Stereotopy head waving bouts, day 70.10.10.6-0.3-0.3-0.3-0.30.70.50.3-0.2-0.2-0.3-0.4-0.20.1-0.10.1-0.10.30.00.10.1
Stereotopy head waving duration, day 70.10.10.4-0.4-0.4-0.4-0.30.70.50.3-0.2-0.2-0.3-0.4-0.20.1-0.10.1-0.10.20.00.00.1
Locomotion velocity, session 80.10.20.7-0.0-0.0-0.0-0.00.10.10.3-0.3-0.3-0.2-0.3-0.30.5-0.50.5-0.50.50.7-0.8-0.9
Locomotion distance, session 80.40.61.2-0.5-0.5-0.5-0.50.40.40.7-0.7-0.7-0.6-0.6-0.80.9-0.90.9-0.90.81.0-1.1-1.1
Degree of sensitization distance0.00.00.0-0.0-0.0-0.0-0.00.00.10.1-0.1-0.1-0.0-0.1-0.10.1-0.10.1-0.10.00.2-0.1-0.1
Degree of sensitization stereotypy0.00.00.2-0.1-0.1-0.1-0.10.40.20.00.00.0-0.1-0.10.1-0.10.1-0.10.2-0.0-0.20.30.3
Conditioned locomotion0.10.20.5-0.3-0.2-0.2-0.20.1-0.10.3-0.4-0.4-0.1-0.1-0.30.5-0.50.4-0.50.00.6-0.7-0.7
Cocaine response after cond. corrected2.03.14.31.61.51.61.6-1.4-1.3-1.71.81.81.51.51.8-1.91.9-1.91.9-2.0-2.02.12.1
Cocaine response after cond. not corrected0.10.10.4-0.0-0.1-0.1-0.10.20.4-0.10.10.2-0.2-0.20.1-0.30.3-0.20.3-0.3-0.50.60.7
Cocaine response before conditioning8.19.711.4-3.1-3.1-3.1-3.13.23.23.2-3.1-3.1-3.2-3.2-3.23.1-3.13.1-3.13.43.0-2.8-2.7
Saline control response0.30.41.4-0.3-0.3-0.3-0.30.10.10.5-0.5-0.6-0.2-0.3-0.50.7-0.70.7-0.7-0.00.9-1.1-1.2
Bone: connectivity density0.00.00.20.20.20.20.2-0.2-0.2-0.20.20.20.20.20.2-0.20.2-0.20.2-0.4-0.20.20.2
Bone: cortical apparent density0.20.20.7-0.2-0.3-0.3-0.3-0.30.20.4-0.4-0.4-0.3-0.4-0.50.6-0.60.6-0.60.10.8-0.8-0.8
Bone: cortical area0.71.11.5-1.2-1.2-1.2-1.21.20.91.1-1.1-1.1-1.0-1.0-1.11.0-1.01.0-1.00.90.9-0.8-0.8
Bone: cortical porosity0.70.80.90.90.90.90.9-0.3-0.7-0.90.90.90.80.80.9-1.01.0-1.01.0-0.8-1.00.90.9
Bone: cortical porosity0.30.40.80.50.50.50.50.2-0.2-0.50.60.60.40.40.6-0.70.7-0.70.7-0.5-0.80.90.9
Bone: cortical thickness0.20.30.90.70.70.70.7-0.8-1.0-0.60.50.50.80.80.6-0.50.5-0.50.4-0.5-0.30.20.1
Bone: cortical thickness0.20.20.5-0.4-0.4-0.4-0.40.00.30.4-0.5-0.5-0.4-0.4-0.50.6-0.60.6-0.60.40.6-0.7-0.7
Bone: cortical tissue density0.10.20.6-0.2-0.2-0.2-0.2-0.30.10.3-0.4-0.4-0.3-0.3-0.50.6-0.60.6-0.60.00.7-0.7-0.7
Condit. Reinf. active minus inactive responses0.30.30.50.50.50.50.5-0.3-0.6-0.50.50.50.50.60.5-0.50.5-0.50.5-0.7-0.50.50.5
Condit. Reinf. active-inactive response ratio2.02.13.31.41.41.41.4-1.4-1.6-1.41.41.41.51.61.5-1.41.4-1.41.4-1.8-1.41.31.3
Condit. Reinf. active responses0.10.10.4-0.3-0.3-0.3-0.30.60.40.3-0.3-0.3-0.4-0.3-0.30.3-0.30.3-0.30.30.2-0.2-0.2
Condit. Reinf. inactive responses3.44.46.1-2.1-2.0-2.1-2.12.32.32.1-2.1-2.1-2.2-2.2-2.12.1-2.12.1-2.12.52.0-1.9-1.9
Incentive salience index mean0.00.10.1-0.2-0.3-0.3-0.30.30.10.3-0.2-0.2-0.2-0.2-0.20.2-0.20.2-0.20.10.2-0.2-0.2
Condit. Reinf. lever presses0.71.01.2-1.1-1.1-1.1-1.10.80.91.0-1.1-1.1-1.0-1.0-1.11.0-1.01.0-1.01.11.0-0.9-0.9
Condit. Reinf. active minus inactive responses3.24.95.7-2.4-2.4-2.4-2.42.42.22.3-2.3-2.3-2.2-2.2-2.22.2-2.22.1-2.12.32.1-1.9-1.9
Condit. Reinf. active-inactive response ratio3.55.67.4-2.6-2.6-2.6-2.62.72.62.5-2.4-2.4-2.5-2.5-2.42.2-2.22.2-2.22.42.0-1.7-1.6
Condit. Reinf. active responses3.44.95.5-2.3-2.2-2.2-2.22.32.02.3-2.3-2.3-2.1-2.1-2.22.2-2.22.1-2.12.32.2-2.2-2.1
Condit. Reinf. inactive responses0.10.10.4-0.2-0.2-0.2-0.20.40.10.3-0.3-0.3-0.1-0.2-0.20.4-0.40.3-0.30.50.4-0.6-0.6
Condit. Reinf. lever presses0.30.41.7-0.8-0.7-0.8-0.71.31.00.6-0.5-0.5-0.7-0.7-0.40.3-0.30.2-0.20.70.10.10.2
Condit. Reinf. lever reinforcers received4.46.26.7-2.6-2.5-2.5-2.52.62.32.6-2.6-2.6-2.4-2.4-2.52.5-2.52.4-2.42.62.5-2.4-2.4
Conditioned reinforcement - actives0.00.10.4-0.4-0.5-0.4-0.40.20.60.2-0.3-0.3-0.5-0.5-0.40.1-0.20.3-0.30.20.00.10.1
Conditioned reinforcement - inactives1.33.44.2-1.9-1.9-1.9-1.91.51.91.8-1.9-1.9-2.0-2.0-2.01.8-1.81.9-1.92.01.7-1.6-1.5
Conditioned locomotion0.00.00.2-0.2-0.3-0.2-0.20.20.40.1-0.1-0.1-0.3-0.3-0.20.0-0.00.1-0.10.1-0.10.10.1
Patch foraging indifference point 0 sec0.10.20.80.60.60.60.6-0.9-0.8-0.50.40.40.60.50.3-0.30.3-0.10.1-0.5-0.0-0.1-0.2
Patch foraging indifference point AUC0.30.81.01.01.01.01.0-0.9-0.8-0.91.01.00.90.90.9-0.90.9-0.90.9-0.8-0.80.80.8
Delay disc. indifference point, 0s delay0.20.30.9-0.2-0.1-0.2-0.2-0.4-0.30.4-0.4-0.4-0.0-0.1-0.40.6-0.80.6-0.60.20.8-0.9-0.9
Delay disc. indifference point, 16s delay1.11.62.71.11.01.11.1-0.6-0.7-1.31.21.31.01.01.3-1.51.6-1.51.5-1.0-1.61.61.6
Delay disc. indifference point, 2s delay0.30.41.60.60.70.70.6-1.3-0.7-0.70.50.50.70.70.6-0.40.5-0.50.5-0.6-0.40.20.1
Delay disc. indifference point, 24s delay0.61.01.51.00.90.91.0-0.6-0.7-1.01.01.00.90.91.0-1.21.2-1.11.1-0.8-1.21.21.2
Delay disc. indifference point, 4s delay0.00.00.1-0.2-0.2-0.2-0.20.00.20.1-0.2-0.2-0.2-0.1-0.10.1-0.10.0-0.00.20.0-0.0-0.0
Delay disc. indifference point, 8s delay0.00.10.20.30.30.30.3-0.5-0.4-0.30.20.20.30.30.2-0.20.2-0.20.2-0.2-0.10.10.1
Indifference point function ln k3.09.09.7-3.1-3.0-3.0-3.02.82.73.0-3.1-3.1-2.9-2.9-3.13.0-3.03.1-3.13.13.0-2.9-2.9
Indifference point function log k3.09.09.7-3.1-3.0-3.0-3.02.82.73.0-3.1-3.1-2.9-2.9-3.13.0-3.03.1-3.13.13.0-2.9-2.9
Patch foraging total patch changes 0 sec0.10.20.80.50.60.60.5-0.9-0.8-0.50.40.40.60.50.3-0.30.3-0.10.1-0.5-0.0-0.1-0.2
Patch foraging total patch changes 12 sec0.30.40.50.70.60.60.7-0.5-0.4-0.70.70.70.50.50.5-0.70.6-0.50.5-0.7-0.60.70.7
Patch foraging total patch changes 18 sec0.30.71.10.90.90.90.9-1.0-1.0-0.80.80.80.90.90.8-0.70.7-0.80.8-1.0-0.60.60.5
Patch foraging total patch changes 24 sec0.00.10.40.20.10.10.10.20.3-0.20.30.3-0.0-0.00.3-0.40.4-0.40.4-0.3-0.50.70.7
Patch foraging total patch changes 6 sec0.71.21.61.21.21.21.2-1.1-1.0-1.21.21.21.11.01.0-1.11.1-1.01.0-1.1-1.01.00.9
Patch foraging time to switch 0 sec1.97.212.42.32.22.32.3-1.6-1.6-2.62.72.72.12.22.7-3.13.1-3.03.0-2.7-3.43.53.5
Patch foraging water rate 0 sec0.51.83.1-1.1-1.1-1.1-1.10.80.71.3-1.3-1.3-1.0-1.0-1.41.5-1.51.5-1.51.41.7-1.7-1.8
Patch foraging water rate 12 sec1.35.27.4-2.1-2.0-2.1-2.11.71.72.3-2.3-2.3-2.0-2.0-2.22.6-2.52.4-2.42.32.7-2.7-2.7
Patch foraging water rate 18 sec1.02.13.5-1.4-1.3-1.3-1.41.00.91.5-1.5-1.6-1.2-1.2-1.41.6-1.61.5-1.51.51.8-1.8-1.9
Patch foraging water rate 24 sec1.21.82.4-1.3-1.2-1.2-1.21.00.91.3-1.4-1.4-1.2-1.1-1.41.4-1.41.5-1.51.31.5-1.6-1.6
Patch foraging water rate 6 sec5.37.89.6-3.0-3.0-3.0-3.03.13.12.9-2.9-2.9-2.9-2.9-2.72.7-2.72.5-2.52.82.5-2.3-2.2
Seeking ratio, delayed vs. immediate footshock0.40.51.5-0.4-0.4-0.4-0.40.1-0.20.6-0.6-0.7-0.2-0.3-0.70.9-0.90.9-0.90.41.1-1.2-1.2
Distance traveled before self-admin2.14.68.0-1.9-1.8-1.8-1.81.11.02.1-2.2-2.2-1.6-1.6-2.22.5-2.52.5-2.61.82.7-2.8-2.8
Distance traveled after self-admin0.10.20.80.20.30.30.2-0.4-0.90.1-0.1-0.10.50.4-0.00.4-0.40.3-0.4-0.20.7-0.9-0.9
Extensor digitorum longus weight0.10.40.8-0.9-0.9-0.9-0.80.90.70.7-0.7-0.6-0.7-0.6-0.60.5-0.50.5-0.50.30.3-0.1-0.1
Bone: elastic displacement0.20.20.50.60.60.60.6-0.4-0.7-0.40.50.50.60.50.4-0.30.3-0.30.3-0.1-0.10.10.1
Bone: elastic work0.60.81.1-0.9-0.8-0.8-0.80.60.70.9-0.9-0.9-0.8-0.8-0.91.0-1.01.0-1.01.11.0-1.0-1.0
Bone: endosteal estimation2.15.06.8-2.6-2.6-2.6-2.62.52.52.4-2.3-2.3-2.4-2.4-2.32.1-2.12.1-2.02.01.8-1.5-1.4
Bone: endosteal perimeter1.43.34.4-2.1-2.1-2.1-2.12.01.81.9-1.9-1.9-1.9-1.8-1.91.7-1.71.7-1.71.61.6-1.3-1.3
Epididymis fat weight0.10.52.00.30.30.30.30.1-0.1-0.50.60.60.30.40.7-0.70.9-0.91.0-0.5-1.11.31.4
Delta time in closed arm before/after self-admin0.10.00.10.30.30.30.3-0.40.0-0.30.20.3-0.0-0.0-0.1-0.30.20.1-0.10.1-0.20.20.2
Delta time in open arm before/after self-admin1.72.02.4-1.4-1.4-1.4-1.41.51.11.5-1.5-1.5-1.2-1.2-1.41.6-1.61.5-1.51.11.6-1.5-1.5
Diff in mean of infusions in LGA sessions0.10.20.7-0.3-0.3-0.3-0.3-0.2-0.00.4-0.5-0.5-0.2-0.2-0.40.6-0.60.6-0.60.30.7-0.9-0.9
Delay discount exponential model param0.20.30.5-0.5-0.5-0.5-0.50.70.60.6-0.5-0.5-0.6-0.6-0.50.5-0.50.5-0.50.40.5-0.4-0.4
Extinction: sum of active levers before priming0.00.00.10.20.20.20.2-0.1-0.40.10.10.10.30.20.10.2-0.1-0.0-0.0-0.10.2-0.2-0.2
Active lever presses in extinction session 60.60.61.60.50.40.40.50.0-0.1-0.70.70.70.50.50.8-1.01.0-1.01.0-0.8-1.21.31.3
Bone: final force2.03.34.0-2.0-2.0-2.0-2.01.61.91.9-1.9-1.9-1.9-1.9-1.91.8-1.81.8-1.81.71.7-1.5-1.4
Bone: final moment2.74.45.1-2.3-2.3-2.3-2.31.82.12.1-2.2-2.2-2.1-2.1-2.22.1-2.12.1-2.12.02.0-1.8-1.7
Food consumed during 24 hour testing period1.22.43.4-1.6-1.6-1.6-1.61.61.81.6-1.5-1.5-1.7-1.7-1.61.5-1.51.5-1.51.61.4-1.2-1.2
Glucose1.21.83.51.51.51.51.5-1.8-1.9-1.41.31.31.61.61.3-1.11.1-1.11.1-1.3-0.90.70.6
Heart weight0.91.42.9-1.4-1.4-1.4-1.41.71.71.2-1.2-1.1-1.5-1.4-1.21.0-1.01.0-0.91.10.7-0.5-0.5
Delay discount hyperbolic model param0.30.30.7-0.5-0.6-0.6-0.50.80.70.6-0.5-0.5-0.6-0.7-0.60.5-0.60.6-0.60.50.5-0.4-0.4
Intermittent access intake day 1-15 change0.10.81.1-1.1-1.0-1.0-1.00.90.91.0-1.0-1.0-0.8-0.8-0.81.0-0.90.8-0.70.70.8-0.7-0.7
Intermittent access intake escalation0.21.11.7-1.3-1.3-1.3-1.31.11.11.2-1.2-1.2-1.0-1.0-0.91.1-1.10.8-0.80.90.9-0.8-0.8
Intermittent access intake escalation 20.20.30.7-0.6-0.5-0.5-0.50.20.10.6-0.6-0.6-0.3-0.3-0.40.8-0.80.5-0.50.40.8-0.8-0.9
Intermitt. access day 1 inactive lever presses0.11.42.5-1.3-1.4-1.4-1.31.51.61.3-1.2-1.2-1.4-1.4-1.11.0-1.01.0-1.01.20.8-0.6-0.5
Intermitt. access day 15 inactive lever presses0.52.85.3-1.7-1.8-1.7-1.72.22.31.6-1.5-1.5-2.1-2.1-1.91.3-1.31.7-1.71.81.0-0.8-0.7
Intermitt. access escalation Index0.20.50.90.70.70.70.7-1.0-1.0-0.70.70.70.90.90.7-0.60.6-0.60.6-0.9-0.60.50.4
Intermittent access day 1 total infusions0.10.30.6-0.7-0.7-0.7-0.70.50.80.5-0.6-0.6-0.7-0.7-0.50.4-0.40.4-0.40.50.3-0.2-0.2
Intermittent access day 15 total infusions0.30.61.2-1.1-1.1-1.1-1.10.81.00.9-0.9-0.9-0.8-0.8-0.60.7-0.70.5-0.50.60.5-0.3-0.3
Intermittent access terminal intake (last 3 days)0.40.61.2-1.1-1.0-1.0-1.00.70.90.9-0.9-0.9-0.8-0.8-0.60.8-0.80.5-0.50.60.6-0.5-0.5
Intermittent access total infusions0.91.11.7-1.3-1.3-1.3-1.30.91.31.1-1.1-1.1-1.2-1.1-1.01.0-1.00.9-0.80.90.8-0.6-0.6
Intermittent access day 1 locomotion0.61.01.5-1.2-1.2-1.2-1.20.81.21.0-1.1-1.1-1.1-1.1-1.01.0-1.00.9-0.91.00.9-0.7-0.7
Intermittent access day 15 total locomotion0.62.13.0-1.6-1.6-1.6-1.60.71.01.6-1.6-1.7-1.1-1.1-1.31.7-1.71.4-1.41.21.7-1.7-1.7
Intermittent access total locomotion2.73.24.4-2.1-2.1-2.1-2.11.41.71.9-2.0-2.0-1.7-1.7-1.71.9-1.91.6-1.61.51.7-1.6-1.5
Intermittent access standard deviation0.10.30.80.40.40.40.4-0.9-0.9-0.40.40.40.80.80.7-0.30.3-0.60.6-0.8-0.20.20.1
Left kidney weight2.721.327.9-5.1-5.1-5.1-5.15.34.94.9-4.8-4.7-4.8-4.7-4.64.6-4.44.3-4.24.44.0-3.5-3.4
Right kidney weight2.819.729.6-4.9-5.0-4.9-4.95.45.14.6-4.5-4.5-4.9-4.8-4.44.0-4.14.1-4.04.43.5-3.0-2.8
Cocaine induced anxiety0.41.22.1-1.1-1.1-1.1-1.11.41.11.1-1.1-1.1-1.1-1.1-1.11.0-1.01.0-1.01.00.9-0.9-0.8
Post-drug Anxiety0.30.31.5-0.6-0.6-0.6-0.61.20.80.6-0.5-0.4-0.6-0.6-0.40.3-0.30.3-0.20.50.1-0.0-0.0
Baseline Anxiety0.50.91.10.90.90.90.9-1.0-0.9-0.90.90.90.90.91.0-1.01.0-1.01.0-0.8-0.90.90.9
Tail length2.111.415.1-3.6-3.7-3.6-3.63.93.83.5-3.4-3.4-3.7-3.6-3.43.2-3.23.2-3.23.12.9-2.5-2.4
Length with tail2.210.015.0-3.6-3.7-3.6-3.63.93.73.3-3.3-3.2-3.4-3.4-3.03.0-2.92.7-2.72.72.4-2.0-1.9
Length without tail0.42.24.8-2.0-2.0-1.9-1.92.21.91.6-1.5-1.5-1.7-1.6-1.31.2-1.11.0-0.91.00.6-0.3-0.3
Times rat made contact with spout0.10.20.30.30.30.30.3-0.1-0.1-0.40.40.40.30.20.4-0.50.5-0.50.5-0.3-0.50.60.6
Lifetime Intake0.60.71.2-1.0-1.1-1.0-1.00.71.10.8-0.9-0.9-1.0-1.0-0.80.8-0.80.8-0.70.80.6-0.5-0.5
Liver weight, left0.81.42.1-1.3-1.3-1.3-1.31.51.41.2-1.2-1.2-1.3-1.3-1.21.1-1.11.1-1.11.20.9-0.8-0.7
Liver weight, right0.00.00.0-0.1-0.1-0.1-0.10.10.10.0-0.0-0.0-0.1-0.1-0.0-0.10.00.0-0.00.2-0.10.10.1
Locomotor activity0.10.20.50.40.40.40.4-0.2-0.1-0.50.50.50.40.30.6-0.50.5-0.70.7-0.2-0.60.60.6
Locomotor testing distance0.00.10.50.10.00.00.00.30.3-0.20.20.2-0.1-0.10.2-0.40.4-0.40.4-0.1-0.50.60.7
Locomotor testing rearing0.10.51.0-0.8-0.8-0.8-0.81.00.90.7-0.6-0.6-0.8-0.8-0.70.6-0.60.6-0.60.50.4-0.2-0.2
Locomotion in novel chamber1.21.52.81.21.21.21.2-1.6-1.6-1.21.11.11.51.51.4-1.10.9-1.31.2-1.7-0.90.70.6
Locomotion in novel chamber post-restriction0.31.01.51.00.91.00.9-1.2-1.0-1.11.01.01.01.01.0-1.11.1-1.01.0-1.0-1.00.90.9
Fecal boli incidents, locomotor time 10.20.40.5-0.7-0.7-0.7-0.70.40.50.7-0.7-0.7-0.6-0.5-0.60.7-0.70.6-0.60.60.7-0.7-0.6
Change in fecal boli incidents, locomotor task2.32.44.11.71.71.71.7-2.0-1.8-1.61.61.61.71.71.5-1.41.4-1.41.4-1.5-1.21.11.0
Time >=10cm from walls, locomotor time 10.00.10.10.20.20.20.2-0.1-0.1-0.20.30.30.10.10.2-0.30.3-0.20.2-0.2-0.30.40.4
Bouts of movement, locomotor time 11.01.33.0-0.8-0.8-0.8-0.80.30.11.2-1.1-1.1-0.7-0.6-1.21.5-1.51.4-1.40.81.7-1.7-1.7
Total resting periods, locomotor time 10.30.31.0-0.3-0.2-0.3-0.3-0.3-0.40.5-0.5-0.5-0.10.0-0.40.8-0.80.6-0.60.21.0-1.0-1.0
Rest time, locomotor task time 10.81.31.6-1.3-1.3-1.3-1.31.11.21.2-1.2-1.2-1.2-1.1-1.11.2-1.21.0-1.01.11.1-0.9-0.8
Distance moved, locomotor task time 10.51.51.81.31.31.31.3-1.1-1.3-1.31.21.21.41.31.3-1.21.2-1.21.2-1.2-1.10.90.8
Vertical activity count, locomotor time 10.32.04.61.61.71.61.6-2.0-2.1-1.41.31.31.81.81.4-1.11.1-1.21.1-1.4-0.70.40.4
Time >=10cm from walls, locomotor time 20.41.11.21.11.11.11.1-0.9-0.9-1.11.11.11.00.91.0-1.11.1-1.01.0-1.0-1.01.01.0
Bouts of movement, locomotor time 20.00.00.0-0.1-0.1-0.1-0.10.10.00.1-0.1-0.1-0.1-0.1-0.10.1-0.10.1-0.10.10.1-0.1-0.0
Total resting periods, locomotor time 20.00.00.1-0.2-0.2-0.2-0.20.00.10.2-0.2-0.2-0.2-0.1-0.20.2-0.20.2-0.20.20.2-0.2-0.2
Rest time, locomotor task time 20.10.20.4-0.2-0.2-0.2-0.2-0.1-0.00.3-0.4-0.4-0.2-0.2-0.40.5-0.50.5-0.50.30.6-0.6-0.6
Distance moved, locomotor task time 20.10.20.20.40.50.50.5-0.3-0.4-0.40.40.40.50.40.5-0.40.4-0.40.4-0.4-0.40.30.3
Vertical activity count, locomotor time 20.10.20.50.40.40.40.4-0.6-0.7-0.30.30.30.60.60.4-0.30.3-0.40.4-0.4-0.20.10.0
Light reinforcement 10.10.31.2-0.0-0.0-0.0-0.0-0.5-0.30.2-0.3-0.3-0.0-0.1-0.50.6-0.60.7-0.8-0.10.8-1.0-1.1
Light reinforcement 20.71.53.11.31.31.31.3-1.8-1.8-1.21.11.11.51.51.2-0.90.9-1.01.0-1.6-0.70.50.4
Bone: marrow area2.05.06.8-2.6-2.6-2.6-2.62.52.52.4-2.3-2.3-2.4-2.3-2.32.1-2.12.1-2.02.01.8-1.4-1.4
Bone: maximum diameter0.61.22.3-1.4-1.4-1.4-1.41.51.11.2-1.2-1.2-1.2-1.1-1.10.9-0.90.9-0.90.90.7-0.5-0.5
Bone: maximum force2.44.76.0-2.4-2.5-2.4-2.42.32.42.3-2.3-2.2-2.3-2.3-2.22.1-2.12.1-2.11.91.9-1.6-1.5
Bone: maximum moment3.05.77.1-2.6-2.7-2.7-2.62.42.52.5-2.5-2.5-2.5-2.5-2.52.3-2.32.3-2.32.22.1-1.9-1.8
Mean time between licks in bursts0.10.30.90.70.80.70.7-0.9-0.7-0.60.50.50.70.60.5-0.40.4-0.40.3-0.3-0.2-0.0-0.1
Mean num. licks in bursts0.00.00.1-0.3-0.3-0.3-0.30.30.30.2-0.2-0.2-0.3-0.2-0.20.1-0.10.1-0.10.1-0.00.10.2
Cd content in liver2.32.62.8-1.7-1.7-1.7-1.71.61.61.6-1.7-1.7-1.6-1.6-1.61.6-1.61.6-1.61.41.6-1.5-1.4
Co content in liver1.51.83.0-1.1-1.1-1.1-1.10.51.11.2-1.3-1.3-1.1-1.3-1.41.5-1.51.5-1.51.11.7-1.7-1.7
Cu content in liver0.80.91.5-1.0-1.0-1.0-1.01.01.20.9-1.0-0.9-1.1-1.1-0.90.9-0.90.9-0.90.60.8-0.7-0.7
Fe content in liver0.20.30.4-0.6-0.6-0.6-0.60.50.50.6-0.6-0.6-0.5-0.5-0.50.5-0.50.5-0.50.30.5-0.4-0.4
K content in liver0.00.00.10.10.00.10.10.20.3-0.00.10.1-0.1-0.20.0-0.00.0-0.00.0-0.2-0.00.00.0
Mg content in liver0.30.30.60.40.40.40.4-0.1-0.1-0.50.50.60.30.30.5-0.60.6-0.60.6-0.8-0.70.80.8
Mn content in liver0.10.10.40.20.20.20.20.3-0.1-0.20.30.40.20.30.3-0.40.4-0.40.4-0.6-0.50.60.6
Na content in liver2.62.93.61.91.91.91.9-1.5-1.5-1.81.81.81.71.61.7-1.71.7-1.71.7-1.9-1.51.41.3
Rb content in liver1.92.24.6-1.6-1.7-1.6-1.62.22.01.5-1.5-1.4-1.8-1.7-1.41.3-1.31.3-1.21.41.0-0.8-0.8
Se content in liver2.93.44.31.71.71.71.7-1.5-2.0-1.81.81.81.92.01.9-1.91.9-1.91.9-2.1-1.91.91.9
Sr content in liver3.73.27.42.12.12.12.1-2.7-2.5-1.81.71.72.22.11.6-1.31.3-1.31.3-1.9-0.90.70.6
Zn content in liver1.01.12.00.90.90.90.9-0.6-0.4-1.11.11.10.70.81.1-1.21.2-1.21.2-1.1-1.41.41.4
Bone: minimum diameter3.05.87.6-2.6-2.6-2.6-2.62.72.52.5-2.5-2.4-2.5-2.5-2.42.3-2.32.3-2.32.42.1-1.9-1.8
Time in familiar zone, hab. session 14.14.56.0-2.1-2.1-2.1-2.11.31.62.1-2.2-2.2-1.9-1.9-2.22.3-2.32.3-2.31.82.5-2.3-2.3
Time in novel zone, hab. session 12.62.93.31.81.81.81.8-1.3-1.5-1.81.81.81.71.71.8-1.81.8-1.81.8-1.5-1.81.61.6
Total zone transitions, hab. session 11.52.14.5-1.1-1.1-1.1-1.10.70.81.3-1.4-1.4-1.1-1.2-1.41.7-1.71.7-1.71.71.8-2.1-2.1
Total locomotion distance, hab. session 10.60.92.4-0.6-0.6-0.6-0.60.20.20.8-0.9-0.9-0.6-0.6-0.91.1-1.11.1-1.11.11.3-1.5-1.5
Locomotion velocity, hab. session 10.40.61.6-0.5-0.5-0.5-0.50.20.20.7-0.8-0.8-0.5-0.5-0.80.9-0.90.9-1.01.01.0-1.3-1.3
Time in familiar zone, hab. session 21.92.13.9-1.7-1.7-1.7-1.71.92.01.5-1.5-1.4-1.7-1.7-1.41.2-1.21.2-1.21.21.0-0.7-0.6
Time in novel zone, hab. session 21.51.62.51.41.51.41.4-1.4-1.6-1.31.31.31.41.41.3-1.11.1-1.11.1-1.0-1.00.80.7
Total zone transitions, hab. session 22.93.84.7-1.8-1.8-1.8-1.81.81.61.9-2.0-2.0-1.8-1.8-1.92.0-2.02.0-2.02.22.0-2.1-2.1
Total locomotion distance, hab. session 20.20.30.9-0.3-0.3-0.3-0.30.0-0.10.4-0.5-0.5-0.3-0.2-0.50.6-0.60.6-0.70.70.7-0.9-1.0
Locomotion velocity, hab. session 20.20.20.9-0.2-0.1-0.2-0.2-0.1-0.20.3-0.4-0.4-0.1-0.1-0.40.6-0.60.6-0.60.60.7-0.9-1.0
Novel to familiar place preference ratio0.00.00.0-0.1-0.1-0.1-0.10.20.10.0-0.0-0.0-0.0-0.0-0.0-0.00.0-0.00.0-0.1-0.10.10.1
Novelty place preference0.10.10.2-0.3-0.3-0.3-0.30.40.30.3-0.3-0.3-0.3-0.3-0.30.2-0.20.2-0.20.20.2-0.1-0.1
Time in novel zone, NPP test0.10.10.2-0.4-0.4-0.4-0.40.40.30.3-0.3-0.3-0.3-0.3-0.30.3-0.30.3-0.20.10.2-0.1-0.1
Total zone transitions, NPP test0.50.81.4-0.7-0.7-0.7-0.70.60.80.8-0.9-0.9-0.9-0.9-0.90.9-0.90.9-1.01.21.0-1.1-1.1
Total locomotion distance, NPP test0.40.51.0-0.7-0.7-0.7-0.70.80.80.7-0.7-0.7-0.8-0.7-0.70.7-0.70.7-0.71.00.6-0.6-0.6
Locomotion velocity, NPP test0.50.71.3-0.7-0.7-0.7-0.70.80.80.8-0.8-0.8-0.8-0.8-0.80.8-0.80.8-0.81.10.8-0.9-0.9
Intraocular pressure0.00.00.10.10.20.20.2-0.3-0.1-0.10.10.10.20.10.1-0.00.0-0.10.1-0.10.1-0.1-0.1
Delta distance traveled before/after self-admin2.42.63.01.61.61.61.6-1.3-1.6-1.61.61.61.71.71.7-1.71.7-1.71.7-1.6-1.61.41.4
Delta ambulatory time before/after self-admin1.01.72.01.41.41.41.4-1.2-1.3-1.41.41.41.31.31.4-1.41.3-1.31.3-1.2-1.31.11.1
Parametrial fat weight1.84.24.62.12.12.12.1-2.1-2.1-2.12.12.12.12.12.1-2.02.1-2.02.0-1.9-2.11.91.8
Pavlov. Cond. lever latency0.10.10.20.30.30.30.3-0.3-0.3-0.20.20.20.30.30.2-0.20.2-0.20.1-0.4-0.00.00.0
Pavlov. Cond. magazine entry latency0.91.11.51.01.01.01.0-0.9-0.8-1.11.11.10.91.01.1-1.21.2-1.21.2-0.8-1.21.21.2
Pavlov. Cond. change in total contacts0.20.20.40.50.50.50.5-0.6-0.5-0.50.50.50.50.50.5-0.50.5-0.50.5-0.4-0.50.30.3
Pavlov. Cond. index score0.30.40.40.60.60.60.6-0.6-0.6-0.60.60.60.60.60.6-0.60.6-0.60.6-0.4-0.70.60.6
Pavlov. Cond. latency score0.20.30.40.50.50.50.5-0.5-0.5-0.60.50.50.50.60.6-0.60.6-0.60.6-0.3-0.60.50.5
Pavlov. Cond. lever contacts0.00.10.2-0.3-0.3-0.3-0.30.40.30.1-0.1-0.1-0.3-0.2-0.1-0.00.0-0.00.00.3-0.20.20.3
Pavlov. Cond. magazine entry number0.30.40.6-0.6-0.6-0.6-0.60.50.40.7-0.6-0.7-0.5-0.5-0.70.7-0.70.7-0.70.40.8-0.7-0.7
Pavlov. Cond. intertrial magazine entries0.20.31.4-0.1-0.1-0.1-0.1-0.1-0.20.3-0.4-0.4-0.1-0.1-0.40.6-0.60.6-0.60.40.9-1.1-1.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.50.60.60.60.6-0.6-0.6-0.70.60.60.60.70.7-0.70.7-0.70.7-0.4-0.70.60.6
Pavlov. Cond. response bias0.10.20.50.20.20.20.2-0.00.0-0.30.40.40.20.20.4-0.50.5-0.50.5-0.2-0.60.70.7
Pavlov. Cond. lever latency0.30.40.5-0.6-0.6-0.6-0.60.40.70.6-0.6-0.6-0.7-0.7-0.70.6-0.60.7-0.70.30.5-0.5-0.4
Pavlov. Cond. magazine entry latency0.81.21.31.11.11.11.1-0.9-1.1-1.01.11.11.11.11.1-1.11.1-1.11.1-1.0-1.01.11.1
Pavlov. Cond. change in total contacts0.10.20.4-0.5-0.4-0.4-0.40.50.30.5-0.5-0.5-0.3-0.4-0.40.5-0.50.5-0.50.60.6-0.6-0.7
Pavlov. Cond. index score0.10.10.10.30.30.30.3-0.0-0.3-0.30.30.30.30.30.3-0.30.3-0.40.3-0.1-0.30.40.3
Pavlov. Cond. latency score0.30.50.60.70.80.80.8-0.5-0.7-0.70.80.80.80.80.8-0.70.7-0.80.8-0.5-0.70.70.7
Pavlov. Cond. lever contacts0.10.10.20.30.30.30.3-0.1-0.4-0.30.30.30.40.40.4-0.30.3-0.40.4-0.0-0.30.30.2
Pavlov. Cond. magazine entry number0.50.60.8-0.8-0.8-0.8-0.80.80.90.8-0.8-0.8-0.9-0.9-0.80.8-0.80.8-0.80.70.7-0.7-0.7
Pavlov. Cond. intertrial magazine entries2.04.55.2-2.2-2.2-2.2-2.22.32.32.2-2.2-2.2-2.2-2.2-2.12.1-2.12.0-2.02.01.9-1.8-1.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.40.40.40.4-0.2-0.5-0.30.40.40.50.40.4-0.40.4-0.40.4-0.1-0.30.40.3
Pavlov. Cond. response bias0.10.10.5-0.3-0.3-0.3-0.30.60.30.3-0.3-0.3-0.3-0.3-0.20.2-0.20.2-0.20.70.2-0.1-0.2
Time in closed arm before self-admin0.50.81.1-1.0-1.0-1.0-1.01.10.91.0-1.0-1.0-0.9-0.9-0.90.9-0.90.8-0.80.70.8-0.8-0.7
Time in closed arm after self-admin0.00.10.2-0.1-0.1-0.1-0.10.30.5-0.10.00.0-0.3-0.3-0.1-0.20.20.00.00.2-0.30.30.4
Time in open arm before self-admin1.82.22.81.71.61.61.6-1.7-1.4-1.71.61.61.41.41.4-1.51.5-1.31.3-1.2-1.41.31.2
Time in open arm after self-admin0.10.10.40.30.30.30.3-0.4-0.6-0.10.20.10.40.40.20.0-0.0-0.00.0-0.40.2-0.2-0.2
Bone: periosteal estimation1.63.95.2-2.3-2.3-2.3-2.32.22.02.1-2.1-2.1-2.1-2.0-2.01.9-1.91.9-1.81.81.7-1.4-1.3
Bone: periosteal perimeter1.42.83.6-1.9-1.9-1.9-1.91.81.51.8-1.8-1.8-1.6-1.6-1.71.6-1.61.6-1.61.51.5-1.4-1.3
Bone: post-yield work1.83.15.4-2.1-2.1-2.1-2.12.32.11.9-1.8-1.8-2.0-1.9-1.81.5-1.51.5-1.51.21.2-0.9-0.8
Progressive ratio test 1 active lever presses0.71.21.6-1.0-1.0-1.0-1.00.60.81.1-1.1-1.1-1.0-1.0-1.21.2-1.21.2-1.21.01.3-1.2-1.2
Progressive ratio test 1 breakpoint0.71.11.5-1.0-1.0-1.0-1.00.50.81.0-1.1-1.1-1.0-1.0-1.11.2-1.21.2-1.21.01.2-1.2-1.2
Progressive ratio test 1 inactive lever presses1.53.94.7-2.0-2.0-2.0-2.01.72.11.9-2.0-1.9-2.2-2.2-2.11.9-1.92.1-2.12.21.8-1.6-1.6
Progressive ratio test 2 active lever presses0.20.20.6-0.7-0.7-0.7-0.70.60.80.5-0.5-0.5-0.6-0.6-0.40.3-0.30.2-0.20.40.1-0.0-0.0
Progressive ratio test 2 breakpoint0.20.30.8-0.8-0.8-0.8-0.80.70.90.5-0.6-0.6-0.7-0.7-0.40.4-0.40.3-0.30.50.1-0.0-0.0
Progressive ratio test 2 inactive lever presses1.34.14.9-2.2-2.2-2.2-2.22.02.22.0-2.1-2.1-2.2-2.2-2.11.9-2.02.0-2.02.01.7-1.6-1.6
Incentive Sensitization - Responses0.30.82.0-1.2-1.2-1.2-1.21.41.41.0-0.9-0.9-1.1-1.0-0.70.6-0.60.4-0.40.70.3-0.1-0.1
Incentive Sensitization - Breakpoint0.20.51.4-1.0-1.0-0.9-0.91.21.10.7-0.7-0.6-0.8-0.8-0.40.4-0.40.2-0.20.40.10.10.1
Sum of active levers in priming session hrs 5-60.10.10.2-0.00.0-0.0-0.0-0.0-0.30.2-0.1-0.10.20.2-0.00.3-0.30.2-0.2-0.10.4-0.4-0.4
Progressive ratio0.00.10.3-0.1-0.1-0.1-0.10.30.00.3-0.2-0.2-0.2-0.2-0.40.5-0.40.5-0.50.40.5-0.5-0.5
Food seeking constrained by brief footshock2.22.88.1-0.8-0.7-0.7-0.8-0.2-0.21.3-1.4-1.4-0.7-0.8-1.72.1-2.12.3-2.31.32.6-2.8-2.8
Seeking ratio, punishment vs. effort0.51.11.7-1.0-0.9-0.9-1.00.40.61.0-1.1-1.1-0.8-0.8-1.01.1-1.31.1-1.10.91.2-1.3-1.3
Retroperitoneal fat weight4.721.023.14.64.54.64.6-4.3-4.2-4.74.74.74.54.54.7-4.64.8-4.74.7-4.5-4.74.64.6
Reaction time number correct0.00.10.40.40.40.40.4-0.5-0.6-0.30.30.30.50.50.3-0.20.2-0.20.2-0.2-0.10.10.0
Reaction time mean minus median0.00.00.0-0.0-0.1-0.0-0.1-0.0-0.20.1-0.0-0.00.10.10.10.1-0.1-0.10.1-0.00.1-0.0-0.0
Reaction time mean minus median AUC0.00.00.10.10.10.10.1-0.1-0.3-0.10.20.20.20.30.2-0.20.2-0.20.2-0.3-0.20.30.3
Reaction time num false alarms0.00.00.0-0.1-0.1-0.0-0.1-0.2-0.2-0.1-0.1-0.10.10.10.1-0.00.0-0.00.0-0.20.0-0.1-0.1
Reaction time num false alarms AUC0.00.10.50.20.30.30.3-0.7-0.7-0.30.10.10.50.40.2-0.10.1-0.10.1-0.50.1-0.3-0.3
Reaction time trials correct on left0.00.10.40.40.40.40.4-0.5-0.6-0.30.30.30.50.50.3-0.20.2-0.20.2-0.2-0.10.10.0
Reaction time trials on left0.00.10.40.30.40.40.4-0.5-0.6-0.30.30.30.50.50.3-0.20.2-0.20.2-0.2-0.10.00.0
Reaction time mean0.30.61.3-0.8-0.9-0.9-0.91.11.10.8-0.7-0.7-0.9-0.9-0.70.6-0.60.6-0.50.60.5-0.3-0.2
Reaction time mean AUC0.10.10.4-0.4-0.4-0.4-0.40.70.70.3-0.3-0.2-0.5-0.4-0.20.1-0.10.1-0.10.10.00.20.2
Median of all reaction times0.30.51.4-0.8-0.8-0.8-0.81.11.20.7-0.6-0.6-0.9-0.9-0.70.5-0.50.5-0.50.60.3-0.2-0.1
Reaction time omissions0.10.10.30.00.00.00.0-0.4-0.50.1-0.1-0.10.20.3-0.10.3-0.30.2-0.2-0.20.5-0.5-0.6
Reaction time false alarm rate0.00.00.20.00.00.10.0-0.4-0.3-0.1-0.1-0.10.20.20.00.1-0.10.1-0.1-0.30.2-0.3-0.4
Reaction time premature initiation rate0.00.00.1-0.0-0.1-0.1-0.10.20.30.00.00.0-0.1-0.10.0-0.00.0-0.10.1-0.1-0.10.20.2
Reaction time premature initiations0.00.10.20.20.20.20.2-0.1-0.1-0.30.30.30.20.20.3-0.30.3-0.40.4-0.3-0.40.40.4
Std. dev. reaction times0.10.30.7-0.7-0.7-0.7-0.70.90.70.6-0.6-0.6-0.7-0.6-0.50.5-0.50.3-0.30.50.4-0.2-0.2
Reaction time trials completed0.00.10.40.30.40.40.4-0.5-0.6-0.30.30.30.50.50.3-0.20.2-0.20.2-0.2-0.10.00.0
Reaction time trials AUC0.00.10.30.30.30.30.3-0.4-0.6-0.30.30.30.40.50.3-0.20.2-0.30.3-0.2-0.20.20.1
Run reversals in cocaine runway, females0.10.20.6-0.4-0.4-0.4-0.40.80.80.3-0.2-0.2-0.6-0.6-0.40.1-0.10.3-0.30.3-0.00.20.2
Run reversals in cocaine runway, males0.00.00.1-0.0-0.1-0.1-0.1-0.10.2-0.0-0.0-0.0-0.1-0.2-0.0-0.00.00.0-0.0-0.00.00.10.1
Latency to leave start box in cocaine runway0.40.50.7-0.7-0.7-0.7-0.70.80.90.8-0.7-0.7-0.8-0.8-0.70.8-0.70.7-0.70.70.6-0.6-0.5
Latency to leave start box in cocaine runway, F0.10.10.1-0.2-0.2-0.2-0.20.20.30.3-0.2-0.2-0.3-0.3-0.30.3-0.20.3-0.30.30.3-0.2-0.2
Latency to leave start box in cocaine runway, M1.21.11.6-1.3-1.2-1.2-1.21.21.21.1-1.2-1.2-1.1-1.1-0.91.1-1.10.8-0.81.00.8-0.9-0.8
Std. dev. time between licks in bursts0.10.31.40.00.10.10.1-0.3-0.20.2-0.3-0.30.0-0.1-0.30.5-0.50.5-0.60.60.9-1.1-1.2
Total sessions with >9 infusions1.11.31.8-1.2-1.2-1.2-1.20.71.01.1-1.2-1.2-1.1-1.1-1.31.2-1.21.3-1.31.01.2-1.1-1.1
Short access day 1 total inactive lever presses0.20.41.1-0.8-0.9-0.8-0.80.91.00.6-0.6-0.6-0.8-0.8-0.50.3-0.40.4-0.40.60.2-0.1-0.0
Short access day 10 total inactive lever presses0.00.10.2-0.5-0.5-0.5-0.50.30.40.4-0.4-0.4-0.4-0.4-0.30.4-0.30.2-0.20.40.3-0.3-0.2
Short access day 1 total infusions0.00.00.1-0.1-0.1-0.1-0.1-0.20.10.0-0.1-0.1-0.1-0.1-0.20.1-0.10.2-0.20.10.1-0.1-0.1
Short access day 10 total infusions0.00.00.10.10.10.10.1-0.4-0.1-0.10.00.00.00.0-0.00.0-0.00.1-0.1-0.00.0-0.0-0.1
Short access total infusions0.00.00.40.20.20.20.2-0.6-0.2-0.30.20.20.10.10.1-0.20.2-0.00.0-0.1-0.20.10.1
Short access day 1 locomotion0.20.30.6-0.6-0.6-0.6-0.60.40.70.4-0.5-0.5-0.7-0.7-0.60.3-0.40.5-0.50.50.2-0.2-0.2
Short access day 10 total locomotion0.41.83.0-1.3-1.2-1.2-1.20.50.71.3-1.4-1.4-1.0-1.0-1.31.6-1.61.5-1.51.11.7-1.7-1.7
Short access total locomotion0.60.92.0-0.8-0.7-0.7-0.8-0.10.20.8-1.0-1.0-0.6-0.6-0.91.2-1.21.1-1.20.71.3-1.4-1.4
One hour access (0.3 mA shock)3.33.95.2-2.3-2.3-2.2-2.22.12.22.1-2.1-2.1-2.1-2.1-1.91.9-1.91.8-1.81.81.6-1.4-1.4
Compulsive drug intake1.42.02.7-1.6-1.6-1.6-1.61.71.41.6-1.5-1.5-1.3-1.3-1.31.4-1.41.2-1.21.31.3-1.1-1.1
One hour access (shock baseline)0.10.10.6-0.4-0.4-0.4-0.40.40.80.2-0.2-0.2-0.6-0.6-0.40.1-0.10.2-0.20.4-0.10.20.3
Social response proportion0.40.41.4-0.8-0.8-0.8-0.81.11.20.6-0.6-0.6-0.9-0.9-0.50.4-0.40.3-0.30.60.2-0.00.0
Social responses2.53.35.2-1.9-1.9-1.9-1.92.22.31.8-1.8-1.8-2.1-2.1-1.81.6-1.61.7-1.61.81.4-1.3-1.2
Social time3.96.27.4-2.4-2.3-2.4-2.42.22.22.4-2.5-2.5-2.4-2.4-2.62.5-2.62.7-2.72.72.5-2.6-2.6
Soleus weight0.00.10.1-0.3-0.3-0.3-0.30.20.10.3-0.2-0.2-0.1-0.1-0.20.2-0.20.2-0.2-0.30.2-0.1-0.1
Bone: stiffness2.13.94.8-2.2-2.2-2.2-2.22.12.22.0-2.0-2.0-2.1-2.1-2.01.9-1.91.9-1.91.71.7-1.4-1.4
Tibialis anterior weight1.13.74.31.71.71.71.7-1.7-2.0-1.81.81.82.02.11.9-2.02.0-2.02.0-2.1-2.02.02.0
Time to tail flick, vehicle, before self-admin0.60.81.3-0.8-0.8-0.8-0.80.60.50.9-0.9-0.9-0.7-0.7-0.91.1-1.11.0-1.00.81.1-1.1-1.1
Time to tail flick, vehicle, after self-admin0.10.10.3-0.5-0.5-0.5-0.50.50.60.4-0.3-0.3-0.3-0.3-0.10.2-0.2-0.10.10.20.00.10.1
Time to tail flick, test, before self-admin0.20.31.0-0.1-0.0-0.0-0.0-0.9-0.70.2-0.3-0.30.30.3-0.10.6-0.60.3-0.3-0.10.8-1.0-1.0
Time to tail flick, test, after self-admin0.30.30.50.60.60.60.6-0.2-0.3-0.60.60.60.30.30.3-0.70.6-0.30.4-0.4-0.70.70.7
Delta time to tail flick, vehicle, before/after SA0.50.51.10.40.40.40.4-0.5-0.3-0.70.60.60.60.60.9-0.80.9-1.01.1-0.6-1.00.91.0
Delta time to tail flick, test, before/after SA0.10.20.80.1-0.0-0.00.00.90.7-0.10.20.2-0.5-0.4-0.2-0.40.40.0-0.00.2-0.60.70.7
Tibia length3.08.312.7-3.2-3.2-3.2-3.23.63.43.0-2.9-2.9-3.2-3.1-2.92.6-2.62.6-2.62.92.3-1.9-1.8
Ambulatory time before self-admin1.23.65.7-1.7-1.6-1.7-1.71.21.01.9-1.9-2.0-1.5-1.5-2.02.2-2.22.2-2.31.62.4-2.4-2.4
Ambulatory time after self-admin0.40.62.0-0.4-0.4-0.4-0.40.3-0.20.7-0.7-0.7-0.3-0.3-0.81.0-1.01.1-1.10.51.2-1.4-1.4
Bone: tissue strength0.60.61.4-0.6-0.6-0.6-0.6-0.00.10.7-0.8-0.8-0.4-0.4-0.80.9-0.90.9-0.90.61.1-1.2-1.2
Total heroin consumption0.00.00.10.10.10.10.10.0-0.30.10.0-0.00.10.1-0.00.2-0.20.1-0.1-0.10.2-0.2-0.2
Bone: trabecular number0.10.10.30.40.40.40.4-0.5-0.3-0.40.30.30.30.30.3-0.30.3-0.30.2-0.3-0.20.10.1
Bone: trabecular spacing0.00.00.10.00.00.00.0-0.0-0.1-0.10.10.10.10.10.1-0.20.2-0.20.2-0.0-0.20.20.3
Bone: trabecular thickness0.00.00.1-0.0-0.0-0.0-0.00.00.10.0-0.0-0.0-0.1-0.1-0.10.1-0.10.1-0.0-0.20.00.00.0
Bone: trabecular tissue density0.81.52.11.21.21.21.2-0.7-0.8-1.21.31.31.01.01.2-1.31.3-1.31.3-1.3-1.41.41.4
Water consumed over 24 hours0.81.61.8-1.2-1.2-1.2-1.21.01.21.2-1.3-1.3-1.2-1.3-1.31.3-1.31.3-1.31.31.3-1.3-1.3
Number of responses in last shaping day0.00.10.20.20.10.10.1-0.10.3-0.20.20.2-0.2-0.2-0.1-0.30.3-0.00.00.1-0.40.40.5