Hub : Genes

Syngr2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Syngr2	0.03	0.03	8.5e-03	0.01	0.01	0.01	0.01	3.7e-02	4.3e-02	4.1e-02	8.4e-02
2	Liver	gene expression	Syngr2	0.06	0.05	1.7e-07	0.05	0.05	0.04	0.04	3.7e-06	5.1e-06	8.0e-06	9.8e-06
3	Adipose	gene expression	Syngr2	0.03	0.02	1.5e-03	0.02	0.01	0.01	0.01	2.3e-03	9.2e-03	4.6e-02	1.1e-02
4	NAcc	gene expression	Syngr2	0.06	0.07	2.7e-03	0	0.01	0.02	0.02	7.9e-02	2.5e-03	2.0e-04	9.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.6	1.0	2.3	0.4	-1.5	1.2	0.4
Area under the delay curve	1.1	1.3	2.3	-0.6	1.1	-1.2	-1.5
BMI with tail	0.5	1.7	3.7	-1.2	1.1	-0.6	1.9
BMI without tail	0.5	1.4	3.7	0.9	-0.6	0.9	1.9
Body weight	0.7	3.1	5.1	-2.0	2.3	-1.7	0.5
Weight adjusted by age	0.1	0.2	0.8	-0.2	-0.1	-0.0	-0.9
Bone surface	1.5	2.8	7.9	-1.3	0.8	-1.0	-2.8
Bone volume	0.5	1.0	3.1	-0.8	0.1	-0.2	-1.8
Breakpoint value in progressive ratio session	0.7	0.9	2.1	-0.9	0.8	-0.2	-1.4
Number of licking bursts	0.0	0.1	0.1	-0.0	0.3	-0.2	0.3
Context. condit. distance diff. score	0.5	0.6	1.0	-0.7	0.8	-0.6	-1.0
Locomotion velocity, session 1	0.2	0.2	0.4	-0.5	0.4	-0.6	-0.1
Locomotion distance, session 1	2.9	3.7	3.8	1.9	-1.9	1.9	2.0
Locomotion velocity, session 2	0.6	0.7	1.1	0.6	-1.0	0.9	0.9
Locomotion distance, session 2	7.1	9.9	12.3	2.7	-3.5	3.3	3.0
Locomotion velocity, session 3	0.1	0.1	0.2	0.5	0.1	-0.2	-0.1
Locomotion distance, session 3	0.6	0.6	2.1	0.6	-0.1	0.2	1.4
Stereotopy head waving bouts, day 3	2.3	2.7	4.0	-2.0	1.5	-1.5	-1.6
Stereotopy head waving duration, day 3	2.3	2.7	3.9	-1.9	1.3	-1.3	-2.0
Locomotion velocity, session 7	0.1	0.2	0.3	0.4	-0.3	0.3	-0.5
Locomotion distance, session 7	2.4	3.0	4.2	1.8	-1.9	2.1	1.0
Stereotopy head waving bouts, day 7	5.1	5.7	6.3	-2.5	2.5	-2.5	-2.1
Stereotopy head waving duration, day 7	6.1	7.3	8.5	-2.9	2.6	-2.7	-2.6
Locomotion velocity, session 8	0.7	0.9	2.5	-0.8	0.4	-0.5	-1.6
Locomotion distance, session 8	2.2	3.2	4.5	1.7	-2.0	2.1	1.2
Degree of sensitization distance	2.7	2.7	4.3	1.6	-2.0	2.1	-0.2
Degree of sensitization stereotypy	2.1	2.3	3.0	-1.5	1.7	-1.7	-1.0
Conditioned locomotion	0.2	0.2	0.4	0.6	-0.5	0.6	0.0
Cocaine response after cond. corrected	0.2	0.3	0.6	-0.8	0.5	-0.5	-0.3
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.3	0.1	-0.2	-0.5
Cocaine response before conditioning	0.4	0.5	0.6	0.8	-0.7	0.6	-0.6
Saline control response	0.7	0.9	2.1	1.4	-0.9	0.8	-0.1
Bone: connectivity density	1.1	1.7	3.1	1.1	-1.8	1.6	0.1
Bone: cortical apparent density	2.2	3.0	6.2	0.8	-1.7	1.6	2.5
Bone: cortical area	3.2	4.9	8.4	-2.9	2.4	-2.4	-0.3
Bone: cortical porosity	1.9	2.0	3.4	-1.8	1.1	-1.3	-1.3
Bone: cortical porosity	3.0	3.2	4.5	-2.1	1.6	-1.7	-1.8
Bone: cortical thickness	2.1	3.5	12.1	-1.0	0.6	-0.7	3.5
Bone: cortical thickness	1.2	1.5	5.3	-0.2	0.5	-0.5	2.3
Bone: cortical tissue density	2.2	3.0	5.8	0.8	-1.7	1.6	2.4
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.5	-0.4	0.4	-0.3
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	0.1	-0.8	0.6	-0.9
Condit. Reinf. active responses	0.7	0.9	1.6	1.3	-0.9	0.9	0.4
Condit. Reinf. inactive responses	1.0	1.2	2.3	1.5	-0.8	0.8	1.1
Incentive salience index mean	0.1	0.1	0.1	0.3	-0.2	0.1	-0.4
Condit. Reinf. lever presses	0.1	0.2	0.5	0.7	-0.4	0.4	0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.9	-0.1	0.1	-0.3	-0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.0	0.1	-0.2	-0.5
Condit. Reinf. active responses	0.2	0.2	0.4	0.4	-0.7	0.5	-0.4
Condit. Reinf. inactive responses	0.7	0.9	1.4	0.9	-1.2	1.2	0.2
Condit. Reinf. lever presses	1.0	1.4	2.2	1.1	-1.5	1.4	-0.0
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	0.3	-0.7	0.7	-0.1
Conditioned reinforcement - actives	0.3	0.6	1.6	0.4	-0.4	0.6	1.3
Conditioned reinforcement - inactives	0.1	0.2	0.6	-0.1	0.0	0.0	0.8
Conditioned locomotion	0.8	1.1	1.8	0.7	-0.9	1.0	1.4
Patch foraging indifference point 0 sec	0.6	1.1	1.9	1.4	-1.2	1.0	0.4
Patch foraging indifference point AUC	1.3	1.8	3.9	2.0	-1.4	1.2	0.0
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.5	0.6	-0.5	-0.7
Delay disc. indifference point, 16s delay	0.1	0.2	0.3	0.4	-0.2	0.6	-0.2
Delay disc. indifference point, 2s delay	0.6	0.7	1.4	-0.2	0.8	-1.2	-0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.1	-0.4	0.3	-0.2
Delay disc. indifference point, 4s delay	1.1	1.2	1.7	-0.6	1.1	-1.2	-1.3
Delay disc. indifference point, 8s delay	3.7	4.3	5.6	-1.6	2.1	-2.2	-2.4
Indifference point function ln k	0.5	0.9	2.5	-1.0	0.2	-0.1	1.6
Indifference point function log k	0.5	0.9	2.5	-1.0	0.2	-0.1	1.6
Patch foraging total patch changes 0 sec	0.8	1.5	2.4	1.5	-1.4	1.2	0.6
Patch foraging total patch changes 12 sec	3.4	4.4	7.9	2.8	-2.0	2.1	1.1
Patch foraging total patch changes 18 sec	1.7	2.6	5.3	2.3	-1.5	1.6	-0.5
Patch foraging total patch changes 24 sec	0.5	0.8	2.8	0.4	0.2	-0.5	-1.7
Patch foraging total patch changes 6 sec	1.8	2.7	3.5	1.9	-1.7	1.8	1.1
Patch foraging time to switch 0 sec	0.2	0.4	0.5	-0.6	0.7	-0.4	-0.6
Patch foraging water rate 0 sec	0.5	1.0	2.2	1.5	-0.9	0.8	0.4
Patch foraging water rate 12 sec	0.5	1.1	3.2	-0.0	-0.4	1.0	1.8
Patch foraging water rate 18 sec	0.1	0.2	0.5	0.1	-0.5	0.7	0.3
Patch foraging water rate 24 sec	1.0	1.3	2.1	1.3	-1.2	1.4	0.5
Patch foraging water rate 6 sec	0.4	0.6	2.3	0.2	-0.3	0.2	1.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.4	-0.4	0.1	0.2
Distance traveled before self-admin	0.2	0.3	0.6	-0.2	0.6	-0.8	-0.2
Distance traveled after self-admin	0.8	1.0	2.0	0.8	-1.2	1.4	-0.1
Extensor digitorum longus weight	1.2	4.9	7.9	2.2	-1.7	1.9	2.8
Bone: elastic displacement	2.4	2.7	6.1	1.1	-1.4	1.3	2.5
Bone: elastic work	0.7	0.9	1.6	-1.2	0.5	-0.5	1.3
Bone: endosteal estimation	3.1	6.9	17.7	-1.9	1.8	-1.7	-4.2
Bone: endosteal perimeter	7.8	16.6	31.4	-3.7	3.3	-3.3	-5.6
Epididymis fat weight	0.1	0.3	0.4	-0.6	0.6	-0.1	0.6
Delta time in closed arm before/after self-admin	0.5	0.4	1.5	0.4	-0.1	0.2	-1.2
Delta time in open arm before/after self-admin	1.2	1.2	1.7	1.0	-0.8	1.3	1.2
Diff in mean of infusions in LGA sessions	2.2	2.7	6.3	-1.3	1.3	-1.0	-2.5
Delay discount exponential model param	1.5	1.7	2.6	0.8	-1.3	1.4	1.6
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.3	-0.1	0.0	0.3
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.0	-0.2	-0.0	0.2
Bone: final force	1.2	1.9	4.3	-2.1	1.3	-1.3	-0.1
Bone: final moment	1.3	2.2	5.2	-2.3	1.3	-1.3	-0.2
Food consumed during 24 hour testing period	0.3	0.4	1.3	0.4	-0.4	0.1	-1.2
Glucose	0.7	1.1	1.8	-1.4	1.3	-0.6	0.6
Heart weight	1.0	1.5	2.2	-1.0	1.5	-0.9	1.4
Delay discount hyperbolic model param	1.5	1.7	2.3	0.7	-1.3	1.5	1.5
Intermittent access intake day 1-15 change	0.1	0.2	0.4	-0.1	0.5	-0.6	-0.2
Intermittent access intake escalation	0.0	0.1	0.2	-0.1	0.2	-0.4	0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.0
Intermitt. access day 1 inactive lever presses	0.2	0.7	1.1	-1.0	0.8	-0.9	-0.6
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.4	0.6	-0.4	0.2	0.2
Intermitt. access escalation Index	0.4	0.6	2.1	-0.2	0.3	-0.3	-1.4
Intermittent access day 1 total infusions	0.2	0.3	0.6	-0.7	0.4	-0.1	0.7
Intermittent access day 15 total infusions	0.1	0.1	0.4	0.1	-0.2	0.2	0.6
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.4	-0.7	0.6	-0.4	-0.0
Intermittent access total infusions	0.2	0.2	0.6	-0.8	0.3	-0.3	0.3
Intermittent access day 1 locomotion	0.5	0.6	0.8	0.4	-0.8	0.9	0.9
Intermittent access day 15 total locomotion	0.1	0.2	0.8	-0.2	0.1	-0.2	0.9
Intermittent access total locomotion	0.2	0.2	0.7	-0.2	-0.2	0.2	0.8
Intermittent access standard deviation	3.6	7.5	9.7	-3.0	3.1	-3.0	-1.6
Left kidney weight	1.1	5.0	7.4	-2.7	2.7	-2.0	-1.1
Right kidney weight	0.3	1.5	2.4	-1.6	1.5	-1.2	0.6
Cocaine induced anxiety	0.0	0.1	0.1	-0.1	0.4	-0.3	0.1
Post-drug Anxiety	0.3	0.3	1.1	0.3	0.1	-0.0	1.0
Baseline Anxiety	0.0	0.1	0.1	0.2	-0.3	0.3	0.1
Tail length	0.1	0.4	1.0	0.8	-0.1	0.1	-1.0
Length with tail	0.9	3.9	5.3	-1.8	2.3	-1.9	-1.8
Length without tail	2.2	7.1	9.7	-3.1	3.1	-2.8	-1.1
Times rat made contact with spout	0.1	0.2	0.4	0.6	-0.4	0.4	0.0
Lifetime Intake	0.3	0.3	0.9	-1.0	0.4	-0.2	0.3
Liver weight, left	1.3	2.1	3.4	-1.9	1.5	-1.3	-1.0
Liver weight, right	1.1	1.9	2.0	-1.3	1.4	-1.4	-1.3
Locomotor activity	0.1	0.1	0.4	0.0	-0.6	-0.2	0.2
Locomotor testing distance	0.1	0.1	0.2	-0.3	-0.4	0.3	-0.4
Locomotor testing rearing	0.5	1.1	2.5	1.2	-1.6	0.8	0.3
Locomotion in novel chamber	0.8	1.0	1.6	0.9	-0.9	0.9	-1.3
Locomotion in novel chamber post-restriction	0.8	1.2	4.0	-0.7	0.4	-0.4	-2.0
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.1	-0.1	0.4	0.2
Change in fecal boli incidents, locomotor task	0.0	0.0	0.2	0.1	-0.1	-0.0	0.4
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.2	-0.1	-0.2	0.0	-1.1
Bouts of movement, locomotor time 1	0.2	0.3	1.1	0.0	0.1	0.0	1.0
Total resting periods, locomotor time 1	0.3	0.4	1.4	0.1	0.0	0.2	1.2
Rest time, locomotor task time 1	0.6	0.7	1.1	-1.1	0.9	-0.6	0.7
Distance moved, locomotor task time 1	0.3	0.4	0.8	0.9	-0.7	0.4	-0.5
Vertical activity count, locomotor time 1	0.6	1.4	3.8	1.9	-1.1	0.9	0.3
Time >=10cm from walls, locomotor time 2	0.4	0.6	0.9	0.5	-0.9	0.8	1.0
Bouts of movement, locomotor time 2	0.2	0.4	0.6	-0.8	0.7	-0.4	-0.4
Total resting periods, locomotor time 2	0.3	0.4	0.7	-0.8	0.8	-0.3	-0.6
Rest time, locomotor task time 2	1.3	1.6	2.1	-1.4	1.5	-1.1	-1.1
Distance moved, locomotor task time 2	0.8	1.0	1.8	1.0	-1.0	0.4	1.4
Vertical activity count, locomotor time 2	0.4	0.6	1.3	0.9	-0.4	0.2	1.1
Light reinforcement 1	1.7	4.1	6.9	2.6	-1.8	1.9	1.7
Light reinforcement 2	0.3	0.5	1.4	1.2	-0.2	0.6	0.3
Bone: marrow area	3.1	6.8	17.5	-1.9	1.8	-1.7	-4.2
Bone: maximum diameter	9.6	18.0	21.5	-4.6	4.1	-4.1	-4.2
Bone: maximum force	1.6	2.8	6.5	-2.5	1.5	-1.5	-0.5
Bone: maximum moment	1.7	3.0	7.4	-2.7	1.5	-1.5	-0.5
Mean time between licks in bursts	0.0	0.1	0.1	-0.3	-0.3	0.2	0.3
Mean num. licks in bursts	0.3	0.4	0.7	0.6	-0.8	0.8	0.2
Cd content in liver	1.1	1.2	1.8	0.7	-1.0	1.2	1.3
Co content in liver	0.0	0.0	0.1	-0.3	-0.1	0.2	0.1
Cu content in liver	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.4
Fe content in liver	0.6	0.7	2.7	0.1	-0.1	-0.2	-1.6
K content in liver	0.5	0.5	0.9	0.7	-1.0	0.6	-0.2
Mg content in liver	2.5	2.5	4.3	1.5	-2.1	1.7	0.7
Mn content in liver	0.1	0.1	0.2	-0.3	-0.1	-0.2	-0.4
Na content in liver	0.2	0.2	0.6	-0.1	-0.5	0.1	-0.8
Rb content in liver	1.6	1.9	2.4	1.4	-1.6	1.4	1.1
Se content in liver	0.9	1.0	1.8	1.3	-1.3	0.8	-0.2
Sr content in liver	0.2	0.2	0.6	-0.3	-0.1	0.3	0.8
Zn content in liver	0.1	0.1	0.2	-0.2	0.5	-0.5	-0.2
Bone: minimum diameter	3.8	7.0	10.1	-2.8	2.2	-2.3	-3.2
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.5	-0.0	0.1	0.4
Time in novel zone, hab. session 1	0.3	0.3	0.5	-0.7	0.1	-0.4	-0.6
Total zone transitions, hab. session 1	2.1	2.9	4.0	1.5	-2.0	1.9	1.3
Total locomotion distance, hab. session 1	2.0	2.9	3.2	1.8	-1.7	1.7	1.5
Locomotion velocity, hab. session 1	2.7	3.9	4.1	2.0	-2.0	2.0	1.8
Time in familiar zone, hab. session 2	0.0	0.1	0.1	0.2	-0.1	0.2	0.3
Time in novel zone, hab. session 2	0.4	0.4	0.7	-0.8	0.4	-0.5	-0.7
Total zone transitions, hab. session 2	5.8	7.4	9.5	2.4	-3.0	3.1	2.2
Total locomotion distance, hab. session 2	6.5	8.5	9.4	2.8	-3.0	3.1	2.7
Locomotion velocity, hab. session 2	6.7	9.0	9.9	3.0	-3.1	3.1	2.8
Novel to familiar place preference ratio	1.6	1.7	2.7	1.1	-1.6	1.5	0.8
Novelty place preference	1.1	1.2	2.0	0.9	-1.4	1.3	0.6
Time in novel zone, NPP test	1.5	1.6	2.5	1.0	-1.6	1.5	0.8
Total zone transitions, NPP test	4.3	6.2	7.8	2.5	-2.8	2.7	1.9
Total locomotion distance, NPP test	8.1	11.0	11.2	3.3	-3.3	3.3	3.3
Locomotion velocity, NPP test	6.8	9.5	9.8	3.1	-3.1	3.0	3.1
Intraocular pressure	0.2	0.2	0.4	0.6	-0.1	0.5	-0.6
Delta distance traveled before/after self-admin	1.6	1.7	3.5	0.9	-1.4	1.9	0.7
Delta ambulatory time before/after self-admin	1.6	2.0	4.2	1.0	-1.7	2.0	0.4
Parametrial fat weight	0.0	0.0	0.1	0.0	0.3	0.1	-0.1
Pavlov. Cond. lever latency	0.2	0.2	0.5	0.3	-0.4	0.4	-0.7
Pavlov. Cond. magazine entry latency	2.1	2.6	3.1	-1.6	1.5	-1.6	-1.7
Pavlov. Cond. change in total contacts	0.6	0.6	1.9	0.0	-0.5	0.5	1.4
Pavlov. Cond. index score	0.8	1.1	1.3	-1.1	1.1	-1.1	-0.7
Pavlov. Cond. latency score	1.1	1.4	1.9	-1.2	1.3	-1.4	-0.7
Pavlov. Cond. lever contacts	0.1	0.2	0.5	-0.1	0.2	-0.2	0.7
Pavlov. Cond. magazine entry number	2.2	2.8	3.4	1.8	-1.6	1.7	1.5
Pavlov. Cond. intertrial magazine entries	1.7	2.0	2.7	1.6	-1.4	1.5	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.9	0.8	-0.9	-0.5
Pavlov. Cond. response bias	1.0	1.3	1.8	-1.4	1.1	-1.2	-0.7
Pavlov. Cond. lever latency	0.7	0.9	1.4	-1.0	1.2	-1.1	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.2	-0.1	0.3	0.4
Pavlov. Cond. change in total contacts	0.4	0.7	0.9	0.9	-0.9	0.9	0.5
Pavlov. Cond. index score	0.3	0.4	0.5	0.7	-0.6	0.7	0.1
Pavlov. Cond. latency score	0.1	0.2	0.2	0.5	-0.4	0.5	-0.2
Pavlov. Cond. lever contacts	1.0	1.4	1.8	1.3	-1.4	1.3	-0.3
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.5	0.3	-0.5	-0.4
Pavlov. Cond. intertrial magazine entries	0.7	1.1	2.9	0.7	-0.7	0.6	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.7	-0.6	0.7	-0.0
Pavlov. Cond. response bias	0.8	1.1	1.5	1.2	-1.1	1.2	0.4
Time in closed arm before self-admin	0.4	0.5	1.8	-0.2	0.4	-0.3	1.3
Time in closed arm after self-admin	0.9	1.0	1.3	-1.2	1.1	-1.0	-0.6
Time in open arm before self-admin	0.1	0.1	0.4	-0.3	-0.3	-0.0	-0.6
Time in open arm after self-admin	0.8	0.9	2.0	0.7	-1.0	1.4	0.2
Bone: periosteal estimation	4.1	8.7	10.0	-3.2	2.8	-2.7	-3.1
Bone: periosteal perimeter	7.7	13.3	16.2	-4.0	3.7	-3.7	-3.1
Bone: post-yield work	0.1	0.2	0.4	-0.2	-0.5	0.6	0.3
Progressive ratio test 1 active lever presses	0.1	0.2	0.4	0.1	-0.4	0.6	0.3
Progressive ratio test 1 breakpoint	0.1	0.2	0.4	0.1	-0.4	0.6	0.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.2	0.1	-0.1	-0.1
Progressive ratio test 2 active lever presses	0.5	0.6	1.3	0.2	-0.7	0.7	1.1
Progressive ratio test 2 breakpoint	0.4	0.5	1.2	0.2	-0.6	0.6	1.1
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.5	-0.2	0.1	-0.0	0.7
Incentive Sensitization - Responses	0.3	0.4	0.5	-0.7	0.5	-0.5	0.6
Incentive Sensitization - Breakpoint	0.3	0.4	0.6	-0.8	0.6	-0.6	0.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	-0.9	0.3	-0.5	-0.2
Progressive ratio	0.1	0.2	0.4	-0.6	0.5	-0.3	0.2
Food seeking constrained by brief footshock	1.2	1.5	2.3	-1.4	1.4	-1.5	-0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.2	0.3	-0.6	-0.4
Retroperitoneal fat weight	0.1	0.3	0.8	0.1	0.5	-0.3	-0.9
Reaction time number correct	1.9	3.7	5.4	2.2	-2.1	2.3	0.6
Reaction time mean minus median	0.1	0.3	0.4	-0.5	0.6	-0.6	0.3
Reaction time mean minus median AUC	0.2	0.4	0.7	-0.6	0.7	-0.9	-0.5
Reaction time num false alarms	0.1	0.1	0.3	0.4	0.2	-0.5	-0.2
Reaction time num false alarms AUC	0.1	0.1	0.2	0.5	-0.1	-0.2	-0.2
Reaction time trials correct on left	1.9	3.7	5.4	2.2	-2.1	2.3	0.6
Reaction time trials on left	2.0	3.7	5.4	2.2	-2.0	2.3	0.5
Reaction time mean	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.3
Reaction time mean AUC	0.1	0.1	0.3	-0.1	-0.2	0.1	0.6
Median of all reaction times	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.2
Reaction time omissions	0.8	1.2	2.0	-0.7	1.4	-1.1	-1.0
Reaction time false alarm rate	0.5	0.8	1.6	-0.7	0.9	-1.3	-0.5
Reaction time premature initiation rate	3.2	4.5	6.1	1.5	-2.2	2.1	2.5
Reaction time premature initiations	4.3	7.6	9.7	2.5	-3.0	3.1	2.4
Std. dev. reaction times	0.0	0.1	0.3	-0.1	-0.0	-0.0	0.6
Reaction time trials completed	2.0	3.7	5.4	2.2	-2.0	2.3	0.5
Reaction time trials AUC	2.3	4.5	6.4	2.4	-2.3	2.5	0.8
Run reversals in cocaine runway, females	0.7	0.7	1.3	-0.1	1.1	-1.2	-0.4
Run reversals in cocaine runway, males	0.3	0.3	0.5	-0.6	0.6	-0.0	0.7
Latency to leave start box in cocaine runway	0.3	0.3	0.6	0.3	-0.4	0.7	0.7
Latency to leave start box in cocaine runway, F	0.5	0.6	0.9	0.7	-0.7	0.9	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.1	-0.2	0.3	0.6
Std. dev. time between licks in bursts	1.7	2.3	3.3	1.7	-1.8	1.7	0.2
Total sessions with >9 infusions	1.3	1.5	3.5	-1.9	1.3	-0.9	-0.2
Short access day 1 total inactive lever presses	1.2	1.6	3.1	-1.8	1.2	-1.1	-0.9
Short access day 10 total inactive lever presses	0.3	0.8	1.7	-0.5	0.6	-1.0	-1.3
Short access day 1 total infusions	0.9	1.2	2.9	-1.7	1.0	-0.9	-0.3
Short access day 10 total infusions	1.8	2.3	3.9	-2.0	1.4	-1.2	-1.4
Short access total infusions	0.6	0.7	2.0	-1.4	0.8	-0.5	-0.1
Short access day 1 locomotion	0.5	0.6	1.4	-1.2	0.7	-0.6	-0.0
Short access day 10 total locomotion	0.5	1.0	1.5	-1.2	1.1	-1.0	-0.5
Short access total locomotion	1.5	1.8	3.6	-1.9	1.4	-1.3	-0.2
One hour access (0.3 mA shock)	0.3	0.4	0.9	0.3	-0.5	0.5	0.9
Compulsive drug intake	0.4	0.5	0.6	0.7	-0.6	0.8	0.8
One hour access (shock baseline)	0.0	0.0	0.0	-0.2	0.2	-0.2	0.0
Social response proportion	0.3	0.3	1.0	0.6	-0.2	-0.2	1.0
Social responses	0.3	0.4	0.9	0.6	-0.5	-0.1	0.9
Social time	0.5	0.6	1.8	0.6	-0.4	0.5	1.3
Soleus weight	1.0	2.8	6.7	1.5	-1.0	1.3	2.6
Bone: stiffness	1.4	2.2	4.4	-2.1	1.5	-1.5	-0.2
Tibialis anterior weight	0.3	0.9	2.7	0.5	-0.4	0.7	1.6
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.7	0.6	-0.7	0.7	1.3
Time to tail flick, vehicle, after self-admin	1.2	1.5	2.6	-1.3	1.6	-1.4	0.3
Time to tail flick, test, before self-admin	0.9	0.9	1.4	1.2	-1.2	1.0	0.0
Time to tail flick, test, after self-admin	1.8	1.8	2.4	-1.5	1.5	-1.4	-0.9
Delta time to tail flick, vehicle, before/after SA	1.1	1.0	1.4	-0.8	1.2	-1.2	-0.9
Delta time to tail flick, test, before/after SA	2.6	2.7	3.6	-1.8	1.9	-1.9	-0.5
Tibia length	11.5	31.8	41.3	-5.5	6.4	-6.2	-4.1
Ambulatory time before self-admin	0.6	0.9	1.9	-0.5	1.2	-1.4	-0.2
Ambulatory time after self-admin	0.5	0.6	1.3	0.5	-0.8	1.1	-0.0
Bone: tissue strength	0.6	0.6	0.9	-0.3	-1.0	0.9	0.8
Total heroin consumption	3.2	3.8	5.0	-2.2	1.8	-1.6	-2.1
Bone: trabecular number	0.2	0.3	0.7	0.2	-0.8	0.5	-0.1
Bone: trabecular spacing	0.2	0.2	0.6	0.0	0.8	-0.4	-0.3
Bone: trabecular thickness	0.2	0.3	0.7	-0.0	-0.9	0.6	0.2
Bone: trabecular tissue density	0.1	0.2	0.3	0.6	0.5	-0.4	-0.2
Water consumed over 24 hours	0.4	0.5	1.0	1.0	-0.7	0.7	0.3
Number of responses in last shaping day	1.6	1.8	2.7	-1.6	1.4	-1.5	-0.3