Syce3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Syce3	0.09	0.04	1.1e-16	0.11	0.12	0.12	0.12	6.7e-16	2.2e-17	5.0e-18	5.6e-18
2	NAcc	intron excision ratio	chr7_122337027_122344626	0.1	0.04	8.1e-13	0.1	0.09	0.09	0.09	2.7e-14	1.7e-13	4.2e-13	6.5e-14
3	NAcc	isoform ratio	XM_006242244.5	0.07	0.04	8.1e-08	0.06	0.06	0.06	0.06	3.5e-09	9.7e-09	8.1e-09	9.0e-09
4	NAcc	intron excision ratio	chr7_122337027_122344231	0.11	0.05	2.4e-13	0.1	0.09	0.09	0.09	2.4e-14	5.6e-14	2.2e-13	4.3e-14
5	NAcc	alternative TSS	NM_001135253.1	0.08	0.07	3.1e-03	0	0.01	0.01	0.01	2.2e-01	5.5e-03	2.1e-02	2.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.8	2.3	-1.5	0.4	0.4	-0.4	-1.1
Area under the delay curve	0.5	0.8	1.1	-0.1	-1.0	-1.1	1.1	-0.9
BMI with tail	2.5	8.6	16.0	4.0	-3.1	-3.0	3.0	-0.4
BMI without tail	0.3	1.7	6.2	2.5	-0.8	-0.8	0.8	0.5
Body weight	1.0	4.4	10.7	3.3	-2.0	-1.9	1.9	0.2
Weight adjusted by age	1.1	3.3	6.6	2.6	-1.8	-1.8	1.8	-0.2
Bone surface	0.5	1.1	2.7	-1.1	-0.7	-0.7	0.7	-1.6
Bone volume	0.5	1.0	2.4	-1.5	-0.3	-0.3	0.3	-1.6
Breakpoint value in progressive ratio session	0.4	0.7	1.0	0.8	-1.0	-0.9	0.9	-0.5
Number of licking bursts	0.0	0.1	0.2	-0.3	0.5	0.4	-0.4	-0.1
Context. condit. distance diff. score	0.4	0.4	1.8	1.3	0.1	-0.1	0.1	0.6
Locomotion velocity, session 1	0.4	0.4	0.6	0.2	-0.7	-0.7	0.7	-0.8
Locomotion distance, session 1	0.3	0.3	1.3	-1.1	0.3	0.3	-0.3	-0.5
Locomotion velocity, session 2	0.6	0.7	0.9	0.6	-0.9	-0.9	0.9	-0.9
Locomotion distance, session 2	0.1	0.1	0.3	-0.6	0.2	0.2	-0.2	-0.2
Locomotion velocity, session 3	2.5	2.9	4.1	-0.1	2.0	2.0	-2.0	1.5
Locomotion distance, session 3	0.5	0.5	0.7	-0.9	0.7	0.8	-0.8	-0.3
Stereotopy head waving bouts, day 3	0.9	1.1	3.0	-1.7	0.0	-0.1	0.1	-1.5
Stereotopy head waving duration, day 3	0.4	0.5	1.5	-1.2	0.6	0.5	-0.5	-0.6
Locomotion velocity, session 7	0.4	0.4	0.9	-0.4	0.6	0.9	-0.9	-0.1
Locomotion distance, session 7	0.1	0.2	0.3	0.3	0.2	0.5	-0.5	0.5
Stereotopy head waving bouts, day 7	0.2	0.2	0.9	-0.9	0.6	0.1	-0.1	-0.1
Stereotopy head waving duration, day 7	0.9	1.1	2.1	-1.5	1.3	1.0	-1.0	-0.1
Locomotion velocity, session 8	0.1	0.1	0.5	0.2	-0.1	-0.3	0.3	-0.7
Locomotion distance, session 8	0.6	0.8	2.1	1.4	-0.7	-0.9	0.9	-0.0
Degree of sensitization distance	1.5	1.6	2.6	1.6	-1.4	-1.3	1.3	0.0
Degree of sensitization stereotypy	0.4	0.5	1.0	-0.2	1.0	0.6	-0.6	0.8
Conditioned locomotion	0.1	0.1	0.2	0.4	-0.3	-0.1	0.1	-0.1
Cocaine response after cond. corrected	0.2	0.3	0.9	0.9	-0.4	-0.5	0.5	0.3
Cocaine response after cond. not corrected	0.5	0.7	2.2	1.5	-0.5	-0.5	0.5	0.6
Cocaine response before conditioning	0.2	0.3	0.8	0.9	-0.6	-0.4	0.4	0.1
Saline control response	2.0	2.8	4.2	1.3	-1.9	-2.0	2.0	-0.7
Bone: connectivity density	0.6	0.9	1.9	-1.4	0.8	0.7	-0.7	-1.0
Bone: cortical apparent density	1.2	1.8	3.6	-1.9	1.5	1.3	-1.3	-0.2
Bone: cortical area	1.8	3.0	4.5	0.8	-2.1	-1.9	1.9	-1.6
Bone: cortical porosity	1.5	1.6	2.4	1.1	-1.5	-1.3	1.3	-1.1
Bone: cortical porosity	2.4	2.6	3.4	1.8	-1.8	-1.7	1.7	-0.7
Bone: cortical thickness	0.2	0.4	0.6	0.1	-0.7	-0.6	0.6	-0.8
Bone: cortical thickness	0.0	0.0	0.1	0.1	-0.3	-0.2	0.2	-0.1
Bone: cortical tissue density	1.0	1.7	3.0	-1.7	1.5	1.2	-1.2	-0.0
Condit. Reinf. active minus inactive responses	2.3	2.6	4.2	0.6	-1.8	-1.6	1.6	-2.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.8	-0.3	-0.5	-0.4	0.4	-1.3
Condit. Reinf. active responses	2.5	3.2	4.1	1.1	-2.0	-2.0	2.0	-1.7
Condit. Reinf. inactive responses	1.5	2.0	2.7	1.4	-1.6	-1.6	1.6	-0.5
Incentive salience index mean	3.6	4.6	6.0	1.1	-2.4	-2.4	2.4	-2.2
Condit. Reinf. lever presses	2.5	3.8	4.9	1.4	-2.2	-2.2	2.2	-1.6
Condit. Reinf. active minus inactive responses	1.7	2.6	3.6	-0.2	-1.9	-1.8	1.8	-1.7
Condit. Reinf. active-inactive response ratio	0.4	0.7	1.4	-0.4	-0.9	-0.8	0.8	-1.2
Condit. Reinf. active responses	2.8	4.1	6.1	0.5	-2.5	-2.3	2.3	-1.8
Condit. Reinf. inactive responses	1.1	1.7	2.4	1.0	-1.6	-1.5	1.5	-0.6
Condit. Reinf. lever presses	2.6	3.8	5.5	1.1	-2.3	-2.3	2.3	-1.3
Condit. Reinf. lever reinforcers received	3.0	4.3	6.3	0.4	-2.5	-2.4	2.4	-1.8
Conditioned reinforcement - actives	0.3	1.3	1.7	1.3	-1.3	-1.2	1.2	-0.6
Conditioned reinforcement - inactives	0.0	0.1	0.3	0.6	-0.1	-0.1	0.1	-0.0
Conditioned locomotion	1.2	1.8	4.8	2.2	-1.2	-1.1	1.1	0.3
Patch foraging indifference point 0 sec	0.1	0.3	0.4	0.6	-0.6	-0.6	0.6	0.1
Patch foraging indifference point AUC	1.2	2.9	3.7	0.4	-1.8	-1.9	1.9	-1.9
Delay disc. indifference point, 0s delay	4.1	4.6	6.4	1.1	-2.5	-2.5	2.5	-1.7
Delay disc. indifference point, 16s delay	0.5	0.6	1.0	0.2	-0.8	-0.9	0.9	-1.0
Delay disc. indifference point, 2s delay	3.9	4.4	5.6	-0.8	-2.3	-2.3	2.3	-2.4
Delay disc. indifference point, 24s delay	0.1	0.2	0.5	0.7	-0.3	-0.4	0.4	-0.4
Delay disc. indifference point, 4s delay	0.5	0.5	0.9	-0.0	-0.9	-0.9	0.9	-0.3
Delay disc. indifference point, 8s delay	0.0	0.1	0.4	-0.6	0.1	0.1	-0.1	0.1
Indifference point function ln k	0.3	0.8	2.2	1.5	-0.1	0.0	-0.0	1.4
Indifference point function log k	0.3	0.8	2.2	1.5	-0.1	0.0	-0.0	1.4
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	0.3	-0.2	-0.3	0.3	0.1
Patch foraging total patch changes 12 sec	1.7	2.3	3.0	0.3	-1.6	-1.7	1.7	-1.6
Patch foraging total patch changes 18 sec	0.6	1.4	3.5	-1.1	-0.9	-0.9	0.9	-1.9
Patch foraging total patch changes 24 sec	0.3	1.2	3.3	-1.0	-0.7	-0.7	0.7	-1.8
Patch foraging total patch changes 6 sec	0.5	0.9	1.3	0.7	-1.1	-1.2	1.2	-0.5
Patch foraging time to switch 0 sec	0.1	0.4	1.0	-1.0	0.5	0.6	-0.6	-0.3
Patch foraging water rate 0 sec	0.2	0.8	2.0	1.4	0.0	0.0	-0.0	1.4
Patch foraging water rate 12 sec	0.3	1.3	4.1	2.0	-0.5	-0.5	0.5	1.2
Patch foraging water rate 18 sec	0.9	2.1	5.3	2.2	0.1	0.3	-0.3	2.3
Patch foraging water rate 24 sec	1.1	1.6	4.5	1.4	0.8	0.7	-0.7	2.1
Patch foraging water rate 6 sec	0.5	0.7	2.0	1.3	0.1	0.2	-0.2	1.4
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.8	-0.9	0.5	0.5	-0.5	0.0
Distance traveled before self-admin	0.2	0.4	1.2	-1.1	0.3	0.4	-0.4	-0.3
Distance traveled after self-admin	0.2	0.3	0.5	-0.5	0.6	0.7	-0.7	0.2
Extensor digitorum longus weight	0.1	0.3	1.3	1.1	-0.2	-0.1	0.1	0.3
Bone: elastic displacement	0.2	0.3	0.4	-0.0	0.7	0.6	-0.6	0.6
Bone: elastic work	0.3	0.4	0.8	0.9	-0.5	-0.5	0.5	0.2
Bone: endosteal estimation	0.7	1.7	2.5	0.7	-1.6	-1.6	1.6	-0.7
Bone: endosteal perimeter	4.4	10.7	16.5	1.1	-4.1	-3.7	3.7	-2.9
Epididymis fat weight	1.4	7.2	9.6	1.9	-3.1	-2.9	2.9	-2.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.6	-0.4	-0.4	0.4	0.2
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	-0.1
Diff in mean of infusions in LGA sessions	1.8	3.2	4.0	1.5	-2.0	-2.0	2.0	-1.2
Delay discount exponential model param	0.3	0.5	0.6	0.2	0.7	0.8	-0.8	0.7
Extinction: sum of active levers before priming	0.3	0.5	0.9	0.2	-0.9	-0.8	0.8	-0.5
Active lever presses in extinction session 6	1.0	1.0	3.0	1.7	-0.8	-0.8	0.8	0.3
Bone: final force	0.4	0.6	1.1	-0.5	-0.8	-0.7	0.7	-1.0
Bone: final moment	0.2	0.3	0.6	-0.5	-0.5	-0.4	0.4	-0.8
Food consumed during 24 hour testing period	0.5	1.1	2.9	1.7	-1.1	-0.8	0.8	0.3
Glucose	0.1	0.2	0.3	0.2	-0.6	-0.5	0.5	-0.4
Heart weight	0.2	0.3	0.5	0.3	0.6	0.7	-0.7	0.4
Delay discount hyperbolic model param	0.5	0.6	0.8	0.4	0.8	0.9	-0.9	0.9
Intermittent access intake day 1-15 change	0.1	0.8	2.0	1.4	-0.8	-0.8	0.8	0.3
Intermittent access intake escalation	0.2	0.9	2.2	1.5	-0.9	-0.9	0.9	0.2
Intermittent access intake escalation 2	1.8	3.1	3.8	1.9	-2.0	-1.9	1.9	-0.6
Intermitt. access day 1 inactive lever presses	0.1	1.2	1.5	1.1	-1.2	-1.2	1.2	-0.4
Intermitt. access day 15 inactive lever presses	0.2	1.2	3.1	1.8	0.4	0.4	-0.4	1.5
Intermitt. access escalation Index	0.2	0.8	1.0	-0.9	1.0	1.0	-1.0	0.5
Intermittent access day 1 total infusions	0.1	0.2	0.2	0.3	0.4	0.5	-0.5	0.4
Intermittent access day 15 total infusions	0.1	0.3	1.0	1.0	-0.1	-0.1	0.1	0.5
Intermittent access terminal intake (last 3 days)	0.9	1.6	4.1	2.0	-1.2	-1.1	1.1	0.2
Intermittent access total infusions	0.2	0.3	0.9	0.9	-0.4	-0.3	0.3	0.1
Intermittent access day 1 locomotion	0.0	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.2
Intermittent access day 15 total locomotion	0.3	1.3	2.4	1.5	-1.2	-1.1	1.1	-0.1
Intermittent access total locomotion	0.4	0.5	1.6	1.2	-0.5	-0.5	0.5	0.4
Intermittent access standard deviation	0.1	0.5	1.0	0.8	0.5	0.6	-0.6	1.0
Left kidney weight	1.5	11.7	29.9	5.5	-3.1	-3.1	3.1	0.5
Right kidney weight	2.2	15.2	42.5	6.5	-3.4	-3.2	3.2	1.1
Cocaine induced anxiety	0.3	0.7	1.9	1.4	0.2	0.2	-0.2	1.3
Post-drug Anxiety	0.8	0.9	2.1	1.4	0.4	0.4	-0.4	1.5
Baseline Anxiety	0.2	0.4	0.7	-0.8	0.6	0.6	-0.6	-0.1
Tail length	0.2	1.0	1.3	-1.1	1.2	1.1	-1.1	0.0
Length with tail	0.0	0.1	0.2	0.4	-0.3	-0.2	0.2	0.1
Length without tail	0.5	2.4	3.6	1.7	-1.9	-1.7	1.7	-0.3
Times rat made contact with spout	3.6	4.1	8.5	1.1	1.7	2.0	-2.0	2.9
Lifetime Intake	0.2	0.3	1.1	1.1	-0.3	-0.2	0.2	0.3
Liver weight, left	1.0	1.8	2.4	1.3	-1.5	-1.6	1.6	-0.4
Liver weight, right	0.2	0.3	0.5	0.6	-0.6	-0.7	0.7	0.2
Locomotor activity	1.5	2.3	3.4	0.9	-1.7	-1.8	1.8	-0.9
Locomotor testing distance	0.1	0.2	0.7	-0.8	0.3	0.3	-0.3	0.1
Locomotor testing rearing	1.1	4.1	6.2	0.2	-2.4	-2.5	2.5	-1.6
Locomotion in novel chamber	1.1	1.5	2.7	0.7	1.2	1.2	-1.2	1.6
Locomotion in novel chamber post-restriction	0.2	0.6	1.4	-0.4	-0.7	-0.7	0.7	-1.2
Fecal boli incidents, locomotor time 1	0.1	0.4	0.9	-0.9	0.6	0.6	-0.6	0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	1.0	-0.3	-0.3	0.3	0.7
Time >=10cm from walls, locomotor time 1	0.6	0.7	0.9	0.8	-0.9	-1.0	1.0	-0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.0	0.3	0.3	-0.3	-0.3
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.3	0.6	0.6	-0.6	-0.2
Rest time, locomotor task time 1	1.0	1.7	2.3	-0.8	1.5	1.5	-1.5	1.0
Distance moved, locomotor task time 1	0.4	1.3	1.7	0.8	-1.3	-1.3	1.3	-0.8
Vertical activity count, locomotor time 1	0.4	2.9	3.9	1.2	-2.0	-2.0	2.0	-1.2
Time >=10cm from walls, locomotor time 2	0.7	1.9	3.0	1.7	-1.5	-1.5	1.5	-0.3
Bouts of movement, locomotor time 2	0.0	0.1	0.2	-0.5	0.3	0.3	-0.3	-0.0
Total resting periods, locomotor time 2	0.0	0.1	0.4	-0.6	0.2	0.2	-0.2	-0.3
Rest time, locomotor task time 2	1.3	2.2	2.8	-1.4	1.6	1.7	-1.7	0.9
Distance moved, locomotor task time 2	2.4	3.1	4.1	1.7	-2.0	-2.0	2.0	-1.0
Vertical activity count, locomotor time 2	1.4	3.3	4.2	1.7	-2.0	-2.1	2.1	-1.0
Light reinforcement 1	0.4	1.9	3.0	1.1	-1.7	-1.5	1.5	-0.9
Light reinforcement 2	2.4	5.5	7.9	2.7	-2.8	-2.5	2.5	-0.7
Bone: marrow area	0.6	1.5	2.2	0.6	-1.5	-1.5	1.5	-0.7
Bone: maximum diameter	1.9	3.8	5.7	1.1	-2.4	-2.2	2.2	-1.6
Bone: maximum force	0.1	0.2	0.4	0.0	-0.6	-0.5	0.5	-0.5
Bone: maximum moment	0.0	0.0	0.0	-0.1	-0.2	-0.2	0.2	-0.2
Mean time between licks in bursts	0.5	3.1	4.9	-2.2	1.9	1.8	-1.8	0.2
Mean num. licks in bursts	0.4	1.1	3.1	0.8	0.6	0.8	-0.8	1.8
Cd content in liver	0.1	0.2	0.5	-0.7	-0.2	-0.1	0.1	-0.5
Co content in liver	0.5	0.6	0.7	0.7	-0.8	-0.8	0.8	-0.6
Cu content in liver	3.2	3.8	5.2	-1.5	2.2	2.3	-2.3	1.3
Fe content in liver	0.3	0.3	0.5	-0.0	-0.6	-0.7	0.7	-0.6
K content in liver	0.3	0.3	0.8	-0.9	0.0	0.3	-0.3	-0.8
Mg content in liver	0.3	0.3	0.8	-0.8	-0.2	-0.2	0.2	-0.9
Mn content in liver	0.3	0.3	1.3	-0.4	-0.4	-0.2	0.2	-1.1
Na content in liver	1.9	2.1	5.9	-2.4	-0.4	0.1	-0.1	-2.2
Rb content in liver	0.4	0.4	0.6	0.1	-0.8	-0.7	0.7	-0.6
Se content in liver	0.1	0.1	0.1	0.2	0.3	0.3	-0.3	0.4
Sr content in liver	2.0	1.8	2.3	-1.5	1.4	1.5	-1.5	0.3
Zn content in liver	1.5	1.8	2.4	-0.7	1.5	1.5	-1.5	1.2
Bone: minimum diameter	1.5	2.8	4.3	0.4	-2.1	-1.8	1.8	-1.7
Time in familiar zone, hab. session 1	1.2	1.3	2.5	0.7	1.2	1.0	-1.0	1.6
Time in novel zone, hab. session 1	0.8	0.9	2.6	-1.0	-0.6	-0.6	0.6	-1.6
Total zone transitions, hab. session 1	0.2	0.3	0.8	-0.9	0.5	0.3	-0.3	0.2
Total locomotion distance, hab. session 1	0.4	0.6	1.0	1.0	-0.6	-0.8	0.8	0.5
Locomotion velocity, hab. session 1	0.4	0.6	0.8	0.8	-0.8	-0.9	0.9	0.3
Time in familiar zone, hab. session 2	0.4	0.4	0.5	0.7	0.5	0.7	-0.7	0.7
Time in novel zone, hab. session 2	0.4	0.5	1.6	-1.3	0.4	0.2	-0.2	-0.7
Total zone transitions, hab. session 2	0.2	0.3	0.8	0.8	0.1	-0.1	0.1	0.9
Total locomotion distance, hab. session 2	1.0	1.3	4.0	2.0	-0.6	-0.8	0.8	0.9
Locomotion velocity, hab. session 2	1.1	1.5	4.2	2.0	-0.7	-1.0	1.0	0.9
Novel to familiar place preference ratio	1.0	1.3	1.9	-1.4	1.3	1.2	-1.2	0.0
Novelty place preference	1.0	1.2	1.7	-1.2	1.3	1.2	-1.2	0.2
Time in novel zone, NPP test	1.4	1.7	2.4	-1.2	1.6	1.5	-1.5	0.4
Total zone transitions, NPP test	0.1	0.2	0.5	-0.2	0.5	0.2	-0.2	0.7
Total locomotion distance, NPP test	0.4	0.6	0.9	0.9	-0.7	-0.9	0.9	0.2
Locomotion velocity, NPP test	0.5	0.7	1.1	1.1	-0.8	-1.0	1.0	0.2
Intraocular pressure	1.4	2.3	3.6	-0.1	-1.7	-1.6	1.6	-1.9
Delta distance traveled before/after self-admin	0.4	0.5	1.4	1.2	0.4	0.3	-0.3	0.8
Delta ambulatory time before/after self-admin	0.2	0.3	0.7	0.8	0.4	0.4	-0.4	0.6
Parametrial fat weight	0.5	1.2	1.7	0.8	-1.3	-1.3	1.3	-0.2
Pavlov. Cond. lever latency	2.0	2.5	3.2	-1.2	1.8	1.8	-1.8	1.2
Pavlov. Cond. magazine entry latency	0.4	0.6	1.8	-1.0	-0.3	0.0	-0.0	-1.4
Pavlov. Cond. change in total contacts	2.5	2.7	6.0	-0.7	-1.6	-1.5	1.5	-2.4
Pavlov. Cond. index score	0.6	0.8	2.2	-0.3	-0.9	-0.7	0.7	-1.5
Pavlov. Cond. latency score	0.8	1.0	2.2	-0.1	-1.1	-0.9	0.9	-1.5
Pavlov. Cond. lever contacts	1.9	2.3	2.9	0.8	-1.7	-1.6	1.6	-1.6
Pavlov. Cond. magazine entry number	0.5	0.7	2.0	1.0	0.5	0.2	-0.2	1.4
Pavlov. Cond. intertrial magazine entries	1.9	2.3	3.3	1.3	-1.6	-1.8	1.8	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.2	-0.5	-0.9	-0.7	0.7	-1.5
Pavlov. Cond. response bias	0.6	0.8	1.6	0.1	-1.0	-0.8	0.8	-1.3
Pavlov. Cond. lever latency	0.7	1.0	1.3	-1.2	1.1	1.1	-1.1	0.1
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	0.7	-0.9	-0.8	0.8	-0.3
Pavlov. Cond. change in total contacts	0.8	1.9	2.7	0.4	-1.6	-1.6	1.6	-1.1
Pavlov. Cond. index score	0.7	1.1	1.6	1.1	-1.2	-1.2	1.2	-0.2
Pavlov. Cond. latency score	0.8	1.3	1.8	1.4	-1.3	-1.2	1.2	-0.1
Pavlov. Cond. lever contacts	0.8	1.1	1.7	1.3	-1.2	-1.2	1.2	-0.1
Pavlov. Cond. magazine entry number	0.8	1.0	1.4	-1.0	1.2	1.1	-1.1	0.2
Pavlov. Cond. intertrial magazine entries	0.6	1.4	2.5	0.4	1.2	1.2	-1.2	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.1	1.4	1.2	-1.2	-1.2	1.2	-0.1
Pavlov. Cond. response bias	0.6	0.8	1.1	0.6	-1.1	-1.1	1.1	-0.4
Time in closed arm before self-admin	1.9	3.4	7.9	-1.5	-1.4	-1.5	1.5	-2.8
Time in closed arm after self-admin	2.9	3.3	4.2	0.1	-2.1	-2.0	2.0	-2.0
Time in open arm before self-admin	0.8	0.9	1.4	0.2	0.9	1.2	-1.2	1.0
Time in open arm after self-admin	0.1	0.1	0.2	0.1	0.3	0.4	-0.4	0.5
Bone: periosteal estimation	1.5	3.6	5.6	0.8	-2.4	-2.2	2.2	-1.4
Bone: periosteal perimeter	3.6	7.2	11.2	1.3	-3.3	-3.0	3.0	-2.3
Bone: post-yield work	0.6	1.1	1.5	-0.9	1.2	1.1	-1.1	0.8
Progressive ratio test 1 active lever presses	0.5	0.9	1.4	0.1	1.1	1.2	-1.2	0.7
Progressive ratio test 1 breakpoint	0.5	0.9	1.4	-0.0	1.1	1.2	-1.2	0.6
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	0.6	-0.4	-0.3	0.3	-0.1
Progressive ratio test 2 active lever presses	0.4	0.5	1.8	1.3	-0.5	-0.5	0.5	0.1
Progressive ratio test 2 breakpoint	0.3	0.4	1.4	1.2	-0.5	-0.4	0.4	0.0
Progressive ratio test 2 inactive lever presses	0.3	1.1	2.8	1.7	-0.9	-0.9	0.9	0.0
Incentive Sensitization - Responses	0.8	2.1	2.6	1.5	-1.6	-1.6	1.6	-0.7
Incentive Sensitization - Breakpoint	0.8	1.9	2.4	1.4	-1.5	-1.5	1.5	-0.7
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.9	0.0	-0.5	-0.5	0.5	-0.9
Progressive ratio	0.0	0.1	0.2	0.5	-0.1	-0.1	0.1	0.1
Food seeking constrained by brief footshock	1.9	2.4	7.0	2.6	-1.2	-1.2	1.2	0.7
Seeking ratio, punishment vs. effort	0.3	0.6	0.8	0.6	-0.9	-0.9	0.9	-0.2
Retroperitoneal fat weight	1.8	8.0	10.1	3.2	-3.1	-3.0	3.0	-1.2
Reaction time number correct	0.1	0.2	0.4	-0.6	0.2	0.5	-0.5	0.2
Reaction time mean minus median	0.1	0.4	0.6	0.3	-0.6	-0.7	0.7	-0.8
Reaction time mean minus median AUC	0.0	0.2	0.2	0.4	-0.3	-0.5	0.5	-0.2
Reaction time num false alarms	0.2	0.3	1.0	-0.7	-0.1	-0.0	0.0	-1.0
Reaction time num false alarms AUC	0.1	0.2	0.3	-0.5	0.3	0.5	-0.5	-0.5
Reaction time trials correct on left	0.1	0.2	0.4	-0.6	0.2	0.5	-0.5	0.2
Reaction time trials on left	0.1	0.2	0.4	-0.7	0.3	0.5	-0.5	0.2
Reaction time mean	0.6	1.2	2.0	-0.8	1.4	1.3	-1.3	0.5
Reaction time mean AUC	0.5	1.1	1.8	-0.9	1.4	1.2	-1.2	0.4
Median of all reaction times	1.8	2.8	4.3	-1.0	2.1	1.9	-1.9	1.0
Reaction time omissions	0.5	0.9	1.2	-1.0	1.0	1.1	-1.1	-0.2
Reaction time false alarm rate	0.1	0.1	0.6	-0.3	-0.0	-0.0	0.0	-0.8
Reaction time premature initiation rate	4.5	7.0	9.4	1.9	-3.1	-3.0	3.0	-1.9
Reaction time premature initiations	1.2	3.8	5.8	1.2	-2.4	-2.2	2.2	-1.4
Std. dev. reaction times	0.0	0.0	0.0	0.2	0.1	0.0	-0.0	-0.0
Reaction time trials completed	0.1	0.2	0.4	-0.7	0.3	0.5	-0.5	0.2
Reaction time trials AUC	0.0	0.1	0.2	-0.4	0.1	0.4	-0.4	0.3
Run reversals in cocaine runway, females	0.3	0.3	0.4	-0.0	0.7	0.7	-0.7	0.6
Run reversals in cocaine runway, males	0.2	0.3	0.4	-0.5	-0.5	-0.5	0.5	-0.6
Latency to leave start box in cocaine runway	0.5	0.7	2.4	1.5	-0.1	0.0	-0.0	1.1
Latency to leave start box in cocaine runway, F	1.6	2.0	3.3	1.6	1.0	1.2	-1.2	1.8
Latency to leave start box in cocaine runway, M	1.4	1.3	2.1	0.3	-1.4	-1.4	1.4	-0.5
Std. dev. time between licks in bursts	1.4	2.6	3.8	2.0	-1.7	-1.8	1.8	-0.1
Total sessions with >9 infusions	0.2	0.3	0.6	0.8	0.4	0.5	-0.5	0.6
Short access day 1 total inactive lever presses	0.7	1.5	6.3	2.5	-0.3	-0.3	0.3	0.9
Short access day 10 total inactive lever presses	0.8	5.2	9.8	3.1	-2.3	-2.3	2.3	-0.1
Short access day 1 total infusions	0.4	0.7	2.0	1.4	0.3	0.4	-0.4	1.0
Short access day 10 total infusions	0.3	0.5	2.0	1.4	-0.2	-0.2	0.2	0.6
Short access total infusions	0.3	0.5	2.0	1.4	-0.1	-0.0	0.0	0.6
Short access day 1 locomotion	0.3	0.5	1.3	1.1	0.3	0.4	-0.4	0.9
Short access day 10 total locomotion	0.1	0.4	1.4	1.2	-0.4	-0.4	0.4	0.3
Short access total locomotion	0.2	0.3	1.0	1.0	-0.3	-0.2	0.2	0.2
One hour access (0.3 mA shock)	1.6	1.9	3.0	1.7	-1.5	-1.4	1.4	-0.1
Compulsive drug intake	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.2
One hour access (shock baseline)	0.4	1.1	2.2	1.5	-1.1	-1.0	1.0	-0.0
Social response proportion	0.4	0.5	1.2	-0.5	-0.8	-0.5	0.5	-1.1
Social responses	0.7	1.0	1.7	-0.5	-1.0	-1.0	1.0	-1.3
Social time	0.5	0.7	2.0	0.7	0.6	0.6	-0.6	1.4
Soleus weight	0.4	1.3	3.2	1.8	-0.7	-1.0	1.0	0.9
Bone: stiffness	0.0	0.1	0.3	-0.5	0.1	0.2	-0.2	-0.2
Tibialis anterior weight	0.0	0.0	0.1	0.1	-0.0	0.0	-0.0	-0.2
Time to tail flick, vehicle, before self-admin	1.4	1.7	2.1	1.4	-1.5	-1.4	1.4	-0.6
Time to tail flick, vehicle, after self-admin	0.3	0.6	1.0	1.0	-0.8	-0.8	0.8	-0.4
Time to tail flick, test, before self-admin	0.3	0.3	0.7	0.2	-0.5	-0.6	0.6	-0.9
Time to tail flick, test, after self-admin	0.6	0.6	2.7	1.7	0.0	-0.0	0.0	0.7
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.7	-0.8	0.8	0.8	-0.8	0.2
Delta time to tail flick, test, before/after SA	0.4	0.5	1.2	0.7	0.5	0.4	-0.4	1.1
Tibia length	0.4	1.2	1.7	-1.2	0.9	1.3	-1.3	0.7
Ambulatory time before self-admin	0.1	0.5	0.7	-0.6	0.7	0.8	-0.8	0.4
Ambulatory time after self-admin	0.2	0.4	0.7	-0.2	0.7	0.8	-0.8	0.4
Bone: tissue strength	3.1	3.2	4.1	-0.2	2.0	2.0	-2.0	2.0
Total heroin consumption	0.5	0.6	0.8	0.6	-0.9	-0.8	0.8	-0.6
Bone: trabecular number	0.4	0.8	1.5	-1.2	0.7	0.6	-0.6	-1.0
Bone: trabecular spacing	0.9	1.3	3.8	2.0	-0.8	-0.7	0.7	1.0
Bone: trabecular thickness	1.0	1.4	1.9	-0.3	-1.3	-1.3	1.3	-1.4
Bone: trabecular tissue density	0.3	0.6	1.7	-1.3	0.7	0.5	-0.5	-0.3
Water consumed over 24 hours	0.3	0.5	1.4	1.2	-0.1	-0.0	0.0	1.0
Number of responses in last shaping day	0.5	0.6	1.0	-0.3	0.9	1.0	-1.0	0.5