Suox

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	isoform ratio	NM_031127.4	0.02	0.02	6.7e-03	0.02	0.01	0	0.01	5.5e-03	3.3e-02	1.6e-01	3.5e-02
2	Brain	mRNA stability	Suox	0.04	0.03	6.2e-04	0.03	0.03	0.03	0.04	3.7e-04	6.2e-04	3.6e-04	3.2e-04
3	PL	gene expression	Suox	0.03	0.02	4.1e-03	0.02	0.02	0.01	0.02	3.8e-03	4.7e-03	1.7e-02	4.8e-03
4	OFC	gene expression	Suox	0.18	0.13	9.5e-03	0.03	0.05	0.02	0.04	7.4e-02	2.8e-02	1.1e-01	3.6e-02
5	Adipose	gene expression	Suox	0.09	0.06	4.0e-07	0.02	0.06	0.06	0.05	5.0e-03	4.1e-07	9.1e-07	1.6e-06
6	pVTA	intron excision ratio	chr7_1690231_1691518	0.05	0.04	8.6e-03	0.01	0.02	0.01	0.01	9.4e-02	8.0e-03	5.4e-02	3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.7	3.1	6.1	-1.1	-0.1	1.0	-2.1	2.4	2.5
Area under the delay curve	0.1	0.1	0.3	-0.5	0.1	0.3	-0.4	0.4	0.1
BMI with tail	5.2	18.2	30.8	-5.5	5.6	5.3	-3.3	2.3	1.7
BMI without tail	0.8	4.4	7.8	-2.8	2.7	2.8	-1.5	1.0	0.7
Body weight	0.7	2.9	6.0	-2.5	2.3	2.2	-1.0	0.4	0.0
Weight adjusted by age	0.1	0.1	0.3	0.3	-0.1	-0.5	0.4	-0.4	-0.4
Bone surface	2.6	5.1	12.0	-0.7	-0.9	0.9	-2.6	3.1	3.5
Bone volume	2.9	5.8	12.9	-1.1	-0.6	1.1	-2.9	3.3	3.6
Breakpoint value in progressive ratio session	0.5	1.0	1.8	1.3	-1.1	-1.1	1.0	-0.8	-0.6
Number of licking bursts	0.6	1.8	4.5	-1.9	2.1	1.5	-0.5	0.0	-0.3
Context. condit. distance diff. score	0.1	0.1	0.4	-0.4	0.6	0.3	-0.3	0.2	0.1
Locomotion velocity, session 1	1.2	1.4	2.4	-1.0	-0.1	0.7	-1.5	1.5	1.4
Locomotion distance, session 1	0.8	1.1	2.4	-0.2	-0.7	0.1	-1.2	1.4	1.5
Locomotion velocity, session 2	1.0	1.2	2.1	0.7	-1.4	-0.8	-0.7	1.2	1.4
Locomotion distance, session 2	1.2	1.6	5.6	1.0	-2.4	-1.2	-0.3	0.8	1.0
Locomotion velocity, session 3	3.3	3.8	6.2	2.4	-2.5	-2.4	1.6	-1.2	-1.1
Locomotion distance, session 3	0.1	0.1	0.2	0.3	-0.4	-0.3	0.4	-0.4	-0.4
Stereotopy head waving bouts, day 3	3.1	3.7	7.1	2.5	-2.7	-2.4	1.3	-0.8	-0.4
Stereotopy head waving duration, day 3	2.3	2.8	5.6	2.4	-2.1	-2.2	1.2	-0.7	-0.3
Locomotion velocity, session 7	0.1	0.1	0.2	0.2	-0.3	-0.2	-0.3	0.4	0.4
Locomotion distance, session 7	0.2	0.3	0.6	0.0	0.4	-0.0	0.5	-0.7	-0.8
Stereotopy head waving bouts, day 7	0.5	0.6	1.4	0.4	-1.2	-0.6	-0.5	0.8	0.8
Stereotopy head waving duration, day 7	0.6	0.8	1.4	0.3	-1.2	-0.4	-0.8	1.1	1.1
Locomotion velocity, session 8	0.9	1.1	2.5	0.3	-1.6	-0.6	-0.8	1.2	1.2
Locomotion distance, session 8	0.1	0.2	0.7	0.4	-0.9	-0.5	-0.1	0.2	0.2
Degree of sensitization distance	0.4	0.5	0.8	-0.8	0.9	0.8	-0.6	0.5	0.4
Degree of sensitization stereotypy	0.6	0.7	1.2	-0.7	0.1	0.4	-1.1	1.1	1.0
Conditioned locomotion	0.6	0.7	1.5	-0.6	1.2	0.6	0.5	-0.9	-1.1
Cocaine response after cond. corrected	0.8	1.2	3.9	-1.2	2.0	1.1	0.0	-0.4	-0.7
Cocaine response after cond. not corrected	0.9	1.3	3.9	-1.1	2.0	1.2	0.2	-0.6	-0.8
Cocaine response before conditioning	0.3	0.3	0.9	0.8	-1.0	-0.5	0.3	-0.2	0.0
Saline control response	0.2	0.3	0.7	-0.8	0.8	0.6	0.0	-0.3	-0.5
Bone: connectivity density	0.9	1.5	3.1	-0.7	-0.1	0.7	-1.4	1.6	1.8
Bone: cortical apparent density	0.7	1.1	2.1	-1.2	1.5	1.1	-1.0	0.8	0.7
Bone: cortical area	1.9	3.2	5.0	-1.4	0.8	1.6	-2.1	2.1	2.2
Bone: cortical porosity	0.3	0.3	0.7	-0.1	-0.0	0.4	-0.6	0.7	0.8
Bone: cortical porosity	0.8	0.9	1.9	-0.5	0.2	0.7	-1.1	1.2	1.4
Bone: cortical thickness	1.9	3.2	4.1	-1.7	1.5	2.0	-1.9	1.8	1.8
Bone: cortical thickness	0.4	0.4	1.1	-0.8	1.1	0.9	-0.2	-0.0	-0.2
Bone: cortical tissue density	0.5	0.8	1.5	-1.0	1.2	0.9	-0.8	0.7	0.6
Condit. Reinf. active minus inactive responses	1.3	1.5	3.2	1.6	-1.4	-1.8	0.9	-0.6	-0.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	1.0	-0.3	-1.0	0.9	-0.8	-0.6
Condit. Reinf. active responses	1.4	1.8	3.9	1.7	-2.0	-2.0	0.5	-0.0	0.2
Condit. Reinf. inactive responses	0.7	0.9	2.7	0.8	-1.7	-1.0	-0.3	0.6	0.8
Incentive salience index mean	0.6	0.8	1.8	1.0	-1.3	-1.3	0.1	0.3	0.4
Condit. Reinf. lever presses	0.7	1.1	2.1	-0.2	-0.9	-0.1	-1.2	1.5	1.4
Condit. Reinf. active minus inactive responses	2.4	3.7	5.0	2.2	-1.6	-2.0	2.1	-1.9	-1.6
Condit. Reinf. active-inactive response ratio	1.8	2.8	4.2	1.4	-0.6	-1.4	2.0	-2.1	-2.0
Condit. Reinf. active responses	1.3	1.9	3.4	1.8	-1.6	-1.5	1.3	-1.0	-0.7
Condit. Reinf. inactive responses	0.1	0.2	0.5	0.5	-0.7	-0.3	-0.1	0.3	0.5
Condit. Reinf. lever presses	2.3	3.4	4.7	2.2	-1.8	-2.0	1.9	-1.6	-1.4
Condit. Reinf. lever reinforcers received	1.3	1.8	2.9	1.7	-1.3	-1.4	1.4	-1.2	-0.9
Conditioned reinforcement - actives	0.1	0.2	0.6	0.6	0.8	0.4	0.3	-0.2	0.2
Conditioned reinforcement - inactives	0.2	0.5	1.5	0.5	1.2	0.4	0.6	-0.6	-0.3
Conditioned locomotion	1.1	1.6	5.8	2.4	-1.1	-1.2	1.0	-0.4	0.2
Patch foraging indifference point 0 sec	1.9	5.3	8.9	-2.5	2.6	3.0	-2.1	1.7	1.7
Patch foraging indifference point AUC	0.4	1.0	2.1	1.1	-0.9	-1.4	0.9	-0.7	-0.7
Delay disc. indifference point, 0s delay	3.7	4.2	6.1	-2.2	0.9	2.0	-2.5	2.4	2.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	0.3	-0.6	-0.5	-0.0	0.1	0.0
Delay disc. indifference point, 2s delay	0.8	0.9	1.5	-1.1	0.3	0.8	-1.2	1.1	0.9
Delay disc. indifference point, 24s delay	0.2	0.3	0.7	-0.8	0.4	0.9	-0.6	0.4	0.1
Delay disc. indifference point, 4s delay	0.3	0.4	0.6	-0.1	-0.7	-0.0	-0.6	0.8	0.8
Delay disc. indifference point, 8s delay	0.1	0.2	0.4	-0.4	0.6	0.2	0.2	-0.4	-0.6
Indifference point function ln k	0.0	0.1	0.2	-0.0	0.5	0.4	-0.0	0.0	0.1
Indifference point function log k	0.0	0.1	0.2	-0.0	0.5	0.4	-0.0	0.0	0.1
Patch foraging total patch changes 0 sec	1.6	4.6	7.8	-2.3	2.4	2.8	-1.9	1.6	1.5
Patch foraging total patch changes 12 sec	0.9	1.2	2.9	-1.4	1.7	1.4	-0.6	0.3	0.1
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.3	0.1	0.3	-0.4	0.3	0.2
Patch foraging total patch changes 24 sec	0.3	0.9	1.2	-1.0	0.6	1.1	-1.0	0.9	0.8
Patch foraging total patch changes 6 sec	1.3	2.1	3.0	-1.6	1.7	1.6	-1.4	1.2	1.2
Patch foraging time to switch 0 sec	0.3	1.1	1.5	-1.1	0.4	1.1	-1.2	1.2	1.1
Patch foraging water rate 0 sec	0.1	0.5	1.2	-0.4	1.1	0.6	0.4	-0.6	-0.7
Patch foraging water rate 12 sec	0.1	0.6	1.7	-0.4	1.3	0.9	0.4	-0.6	-0.6
Patch foraging water rate 18 sec	1.2	2.8	5.4	0.9	0.5	-0.8	2.0	-2.3	-2.3
Patch foraging water rate 24 sec	1.6	2.3	4.5	-0.4	1.9	0.6	1.4	-1.9	-2.1
Patch foraging water rate 6 sec	1.8	2.6	4.2	1.6	-0.3	-1.1	2.0	-2.0	-1.9
Seeking ratio, delayed vs. immediate footshock	0.5	0.7	1.9	1.4	-1.1	-0.9	0.3	0.0	0.4
Distance traveled before self-admin	0.5	1.2	2.3	1.3	-1.4	-1.5	0.8	-0.6	-0.4
Distance traveled after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.0	-0.0	-0.1
Extensor digitorum longus weight	2.7	10.9	25.0	-4.4	5.0	4.1	-1.9	0.9	0.3
Bone: elastic displacement	0.0	0.0	0.1	0.0	0.1	0.4	-0.1	0.2	0.2
Bone: elastic work	1.2	1.6	2.2	-1.3	0.9	1.5	-1.4	1.3	1.2
Bone: endosteal estimation	0.6	1.5	1.8	-1.1	1.0	1.3	-1.3	1.3	1.3
Bone: endosteal perimeter	0.2	0.5	1.0	0.5	-0.9	-0.4	-0.5	0.8	1.0
Epididymis fat weight	0.2	1.2	2.1	0.8	0.1	-0.9	1.3	-1.4	-1.4
Delta time in closed arm before/after self-admin	1.6	1.5	2.9	-0.1	1.7	0.3	1.1	-1.5	-1.5
Delta time in open arm before/after self-admin	0.7	0.8	1.8	-1.3	0.8	1.2	-0.7	0.5	0.2
Diff in mean of infusions in LGA sessions	1.0	1.9	3.1	1.8	-1.5	-1.6	1.3	-1.0	-0.8
Delay discount exponential model param	0.0	0.1	0.2	0.4	0.0	-0.2	0.3	-0.3	-0.0
Extinction: sum of active levers before priming	1.6	2.4	2.9	1.7	-1.0	-1.6	1.7	-1.6	-1.5
Active lever presses in extinction session 6	0.1	0.1	0.3	0.3	-0.5	-0.3	-0.0	0.1	0.2
Bone: final force	4.0	6.5	7.7	-2.6	1.8	2.8	-2.8	2.6	2.5
Bone: final moment	4.0	6.4	7.7	-2.6	1.8	2.7	-2.8	2.6	2.5
Food consumed during 24 hour testing period	0.2	0.4	0.7	-0.8	0.6	0.7	-0.5	0.4	0.4
Glucose	1.0	1.5	2.9	-1.7	1.3	1.6	-1.0	0.7	0.4
Heart weight	0.5	0.9	1.2	1.0	-0.3	-1.0	1.1	-1.0	-1.0
Delay discount hyperbolic model param	0.3	0.4	0.6	0.8	-0.2	-0.6	0.8	-0.7	-0.4
Intermittent access intake day 1-15 change	0.3	1.6	3.1	1.8	-0.3	-1.0	1.5	-1.4	-1.0
Intermittent access intake escalation	0.3	1.5	2.8	1.7	-0.3	-0.9	1.5	-1.4	-1.1
Intermittent access intake escalation 2	0.7	1.2	2.2	1.5	-0.8	-1.1	1.2	-1.0	-0.8
Intermitt. access day 1 inactive lever presses	0.2	2.5	3.8	1.4	-0.5	-1.2	1.9	-2.0	-1.9
Intermitt. access day 15 inactive lever presses	0.2	1.2	1.6	1.3	-1.0	-1.1	1.1	-1.0	-0.9
Intermitt. access escalation Index	0.2	0.7	1.1	-0.5	-0.3	0.7	-1.0	1.0	1.1
Intermittent access day 1 total infusions	0.1	0.2	0.8	-0.0	0.6	0.9	0.0	-0.1	-0.0
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.7	0.2	0.5	0.3	-0.2	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.6	-0.1	0.6	-0.1	0.3	0.6
Intermittent access total infusions	0.2	0.3	0.9	0.2	0.6	0.9	-0.1	0.2	0.4
Intermittent access day 1 locomotion	0.2	0.3	0.6	0.3	0.5	0.4	0.7	-0.7	-0.7
Intermittent access day 15 total locomotion	0.2	0.9	2.4	1.6	0.1	-0.3	1.2	-1.1	-0.6
Intermittent access total locomotion	0.3	0.3	0.8	0.9	0.2	0.1	0.7	-0.6	-0.4
Intermittent access standard deviation	0.2	0.8	2.7	1.6	-1.0	-0.7	0.6	-0.2	0.3
Left kidney weight	0.0	0.1	0.2	-0.0	0.1	-0.1	0.3	-0.3	-0.5
Right kidney weight	0.1	0.8	1.2	0.7	-0.5	-1.1	1.0	-0.9	-1.0
Cocaine induced anxiety	0.3	0.9	2.7	1.0	-1.6	-1.0	-0.2	0.6	0.8
Post-drug Anxiety	1.1	1.2	2.5	0.3	-1.3	-0.1	-1.0	1.4	1.6
Baseline Anxiety	0.0	0.0	0.0	-0.1	0.0	0.2	-0.1	0.1	0.1
Tail length	1.9	10.2	14.8	3.8	-3.9	-3.8	2.9	-2.3	-2.0
Length with tail	1.4	6.1	8.0	2.8	-2.5	-2.8	2.5	-2.2	-1.9
Length without tail	0.1	0.3	0.9	-0.6	0.9	0.6	0.0	-0.2	-0.3
Times rat made contact with spout	0.5	0.6	1.5	-1.0	1.2	1.0	-0.1	-0.2	-0.3
Lifetime Intake	0.7	0.9	2.5	-0.2	1.1	1.6	-0.5	0.6	0.9
Liver weight, left	0.3	0.5	1.1	-0.9	1.1	0.7	-0.4	0.3	0.1
Liver weight, right	0.2	0.4	0.7	0.2	-0.4	-0.6	0.6	-0.7	-0.8
Locomotor activity	1.5	2.4	6.5	1.8	-2.6	-2.0	0.6	-0.1	0.1
Locomotor testing distance	0.5	1.2	3.0	1.4	-1.7	-1.5	0.4	0.0	0.2
Locomotor testing rearing	0.0	0.1	0.2	0.1	-0.1	-0.2	0.4	-0.4	-0.5
Locomotion in novel chamber	0.0	0.0	0.1	0.0	0.1	0.3	-0.1	0.1	0.3
Locomotion in novel chamber post-restriction	1.3	4.0	7.3	2.5	-2.7	-2.5	1.6	-1.1	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.4	0.8	-0.9	0.8	0.7	0.1	-0.4	-0.6
Change in fecal boli incidents, locomotor task	0.6	0.6	1.2	0.4	-1.1	-0.4	-0.6	0.9	1.1
Time >=10cm from walls, locomotor time 1	1.2	1.5	2.2	-1.0	0.4	1.2	-1.5	1.5	1.5
Bouts of movement, locomotor time 1	0.6	0.8	1.4	1.0	-0.8	-1.2	0.9	-0.7	-0.6
Total resting periods, locomotor time 1	1.1	1.2	2.1	1.3	-1.3	-1.5	1.0	-0.8	-0.6
Rest time, locomotor task time 1	0.2	0.3	1.3	0.5	-1.1	-0.5	0.0	0.2	0.2
Distance moved, locomotor task time 1	0.7	1.9	2.7	-1.1	0.9	1.2	-1.6	1.6	1.7
Vertical activity count, locomotor time 1	0.1	0.9	3.2	-0.8	1.8	1.0	-0.6	0.4	0.4
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.4	-0.8	1.2	1.0	-0.2	-0.1	-0.1
Bouts of movement, locomotor time 2	0.1	0.4	0.8	0.1	-0.7	-0.2	-0.6	0.8	0.9
Total resting periods, locomotor time 2	0.1	0.5	1.2	0.0	-0.8	-0.1	-0.7	1.0	1.1
Rest time, locomotor task time 2	0.2	0.4	0.7	-0.1	-0.8	0.2	-0.6	0.8	0.8
Distance moved, locomotor task time 2	0.2	0.3	0.6	0.3	0.6	-0.1	0.7	-0.7	-0.7
Vertical activity count, locomotor time 2	0.3	0.8	2.7	-0.7	1.6	0.7	0.3	-0.7	-0.8
Light reinforcement 1	0.8	3.8	8.3	2.9	-2.7	-2.1	1.4	-0.8	-0.3
Light reinforcement 2	0.4	0.9	1.8	1.3	-1.3	-0.9	0.7	-0.5	-0.2
Bone: marrow area	0.5	1.3	1.6	-1.0	0.9	1.2	-1.2	1.2	1.3
Bone: maximum diameter	0.4	0.8	1.9	0.5	-1.0	-0.4	-0.7	1.1	1.4
Bone: maximum force	3.1	6.2	7.8	-2.7	1.9	2.8	-2.6	2.4	2.3
Bone: maximum moment	3.2	6.1	7.7	-2.7	1.9	2.8	-2.6	2.4	2.3
Mean time between licks in bursts	0.2	1.0	2.1	1.5	-0.8	-1.2	1.0	-0.8	-0.6
Mean num. licks in bursts	0.1	0.4	1.0	0.9	-1.0	-0.6	0.3	-0.2	-0.0
Cd content in liver	0.3	0.3	0.8	0.9	-0.3	-0.8	0.4	-0.2	-0.0
Co content in liver	2.7	3.2	4.7	2.1	-1.6	-2.2	1.7	-1.5	-1.3
Cu content in liver	1.0	1.2	2.5	-0.5	0.4	0.7	-1.3	1.4	1.6
Fe content in liver	0.1	0.1	0.5	-0.1	0.7	0.4	0.1	-0.2	-0.2
K content in liver	0.4	0.4	1.0	0.7	-1.0	-0.6	-0.1	0.4	0.6
Mg content in liver	0.6	0.7	1.6	0.9	-1.3	-1.2	0.3	-0.0	0.1
Mn content in liver	1.5	1.7	3.4	0.7	-1.6	-0.7	-1.1	1.6	1.8
Na content in liver	0.5	0.5	0.9	-0.4	0.1	0.7	-0.9	0.9	0.9
Rb content in liver	1.0	1.2	2.7	-0.5	0.1	0.4	-1.3	1.5	1.6
Se content in liver	0.0	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.0	-0.0
Sr content in liver	0.6	0.6	0.9	1.0	-0.0	-0.5	0.9	-0.9	-0.7
Zn content in liver	4.9	5.7	7.3	2.4	-1.6	-2.5	2.7	-2.6	-2.4
Bone: minimum diameter	0.7	1.3	2.4	-0.8	0.4	0.9	-1.3	1.4	1.6
Time in familiar zone, hab. session 1	3.6	4.0	5.3	2.3	-2.3	-2.3	1.9	-1.6	-1.5
Time in novel zone, hab. session 1	4.1	4.6	5.4	-2.1	1.8	2.3	-2.3	2.2	2.1
Total zone transitions, hab. session 1	0.5	0.7	1.3	-0.0	-1.0	-0.2	-0.9	1.1	1.2
Total locomotion distance, hab. session 1	1.2	1.7	3.6	0.7	-1.9	-0.7	-0.9	1.4	1.6
Locomotion velocity, hab. session 1	1.0	1.4	3.8	1.0	-2.0	-1.0	-0.5	0.9	1.1
Time in familiar zone, hab. session 2	5.0	5.6	7.3	2.7	-2.2	-2.7	2.5	-2.2	-2.0
Time in novel zone, hab. session 2	5.8	6.4	7.8	-2.8	2.2	2.8	-2.7	2.4	2.2
Total zone transitions, hab. session 2	2.3	3.0	5.0	-1.3	0.4	1.2	-2.2	2.2	2.2
Total locomotion distance, hab. session 2	0.4	0.6	1.0	0.1	-1.0	-0.1	-0.8	1.0	1.0
Locomotion velocity, hab. session 2	0.7	0.9	1.6	-0.0	-1.1	-0.1	-1.0	1.3	1.3
Novel to familiar place preference ratio	3.4	4.5	5.8	-2.1	1.5	2.1	-2.4	2.3	2.1
Novelty place preference	2.5	3.2	4.3	-1.7	1.2	1.7	-2.1	2.0	1.9
Time in novel zone, NPP test	3.0	3.6	4.6	-1.9	1.5	1.9	-2.2	2.0	1.9
Total zone transitions, NPP test	1.0	1.4	2.2	-1.3	0.3	1.0	-1.5	1.4	1.2
Total locomotion distance, NPP test	0.8	1.1	2.0	-0.7	-0.2	0.7	-1.3	1.4	1.3
Locomotion velocity, NPP test	0.5	0.7	1.4	-0.4	-0.5	0.3	-1.1	1.2	1.1
Intraocular pressure	1.0	1.7	3.4	0.7	-0.4	-1.0	1.5	-1.7	-1.8
Delta distance traveled before/after self-admin	0.5	0.5	1.2	-1.0	0.8	1.1	-0.4	0.2	0.1
Delta ambulatory time before/after self-admin	0.5	0.9	1.6	-1.2	0.7	1.3	-0.9	0.8	0.6
Parametrial fat weight	0.4	1.0	1.8	-1.2	0.8	1.4	-0.9	0.8	0.8
Pavlov. Cond. lever latency	0.7	0.9	1.8	0.3	0.4	-0.0	1.2	-1.4	-1.3
Pavlov. Cond. magazine entry latency	1.1	1.4	2.9	1.4	-1.3	-1.7	0.9	-0.7	-0.6
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	-0.4	0.6	0.1	-0.4	0.4	0.4
Pavlov. Cond. index score	0.2	0.3	0.6	0.5	-0.7	-0.8	-0.2	0.4	0.4
Pavlov. Cond. latency score	0.3	0.4	0.7	0.4	-0.8	-0.7	-0.5	0.7	0.8
Pavlov. Cond. lever contacts	0.7	0.9	1.8	-0.5	-0.1	0.2	-1.2	1.4	1.3
Pavlov. Cond. magazine entry number	0.6	0.7	1.7	-0.9	0.8	1.3	-0.7	0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.1	0.6	-0.1	-0.5	1.0	-1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.8	0.6	-0.8	-0.9	-0.1	0.3	0.3
Pavlov. Cond. response bias	0.4	0.5	1.3	0.7	-0.7	-1.1	0.4	-0.3	-0.3
Pavlov. Cond. lever latency	1.0	1.4	2.7	-1.3	1.6	1.4	-1.0	0.7	0.6
Pavlov. Cond. magazine entry latency	1.2	1.7	3.4	1.4	-1.8	-1.8	1.0	-0.7	-0.5
Pavlov. Cond. change in total contacts	0.4	0.9	1.4	1.2	-1.0	-1.2	1.0	-0.8	-0.6
Pavlov. Cond. index score	1.2	1.9	3.0	1.6	-1.7	-1.7	1.2	-0.9	-0.7
Pavlov. Cond. latency score	1.1	1.8	3.5	1.5	-1.9	-1.7	1.1	-0.7	-0.6
Pavlov. Cond. lever contacts	1.1	1.6	2.3	1.4	-1.5	-1.5	1.2	-1.0	-0.8
Pavlov. Cond. magazine entry number	1.3	1.7	3.2	-1.6	1.8	1.8	-1.0	0.6	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.7	1.8	-0.9	1.3	1.1	-0.2	-0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.9	3.2	1.7	-1.8	-1.8	1.1	-0.8	-0.6
Pavlov. Cond. response bias	1.9	2.6	4.0	1.8	-1.8	-2.0	1.6	-1.3	-1.1
Time in closed arm before self-admin	0.5	0.8	1.4	-0.6	-0.0	0.6	-1.1	1.2	1.2
Time in closed arm after self-admin	0.1	0.2	0.7	-0.0	0.8	0.5	-0.0	-0.0	0.2
Time in open arm before self-admin	0.1	0.1	0.2	0.4	0.1	-0.3	0.3	-0.3	-0.1
Time in open arm after self-admin	1.0	1.1	2.3	-1.5	1.3	1.5	-0.6	0.3	-0.1
Bone: periosteal estimation	1.6	3.8	5.7	-1.5	1.0	1.8	-2.2	2.3	2.4
Bone: periosteal perimeter	0.6	1.2	3.0	-0.3	-0.3	0.4	-1.3	1.5	1.7
Bone: post-yield work	0.3	0.6	1.0	-1.0	0.9	0.9	-0.7	0.5	0.5
Progressive ratio test 1 active lever presses	0.2	0.3	1.0	-0.3	1.0	1.0	-0.1	0.1	0.1
Progressive ratio test 1 breakpoint	0.2	0.3	1.0	-0.3	1.0	1.0	-0.1	0.0	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.3	1.1	1.0	-0.3	-0.3	0.6	-0.4	-0.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	0.6	0.1	0.2	0.3	-0.2	0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	0.7	-0.1	0.1	0.3	-0.2	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.5	1.1	-0.0	0.6	1.1	-0.5	0.6	0.8
Incentive Sensitization - Responses	0.1	0.3	0.6	0.8	-0.5	-0.6	0.6	-0.5	-0.4
Incentive Sensitization - Breakpoint	0.2	0.3	0.7	0.8	-0.7	-0.6	0.5	-0.4	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	0.4	-0.3	-0.4	0.4	-0.4	-0.4
Progressive ratio	0.2	0.6	1.8	-0.8	1.3	1.2	-0.2	-0.0	-0.0
Food seeking constrained by brief footshock	1.3	1.7	3.0	1.2	-1.7	-1.7	1.0	-0.9	-1.0
Seeking ratio, punishment vs. effort	0.9	2.0	4.0	1.4	-2.0	-2.0	1.0	-0.7	-0.8
Retroperitoneal fat weight	0.9	4.1	10.2	-2.5	3.2	2.7	-0.6	-0.0	-0.3
Reaction time number correct	0.2	0.7	1.7	-0.9	1.3	0.9	0.2	-0.5	-0.7
Reaction time mean minus median	0.2	1.1	2.3	1.2	-1.5	-1.4	0.6	-0.4	-0.3
Reaction time mean minus median AUC	0.2	1.1	3.3	0.7	-1.8	-0.9	-0.5	0.9	1.0
Reaction time num false alarms	0.3	0.5	1.0	-1.0	1.0	0.9	-0.4	0.2	0.1
Reaction time num false alarms AUC	0.2	0.5	1.1	-0.9	1.1	0.8	-0.2	-0.1	-0.2
Reaction time trials correct on left	0.2	0.7	1.7	-0.9	1.3	0.9	0.2	-0.5	-0.7
Reaction time trials on left	0.2	0.6	1.6	-0.9	1.3	0.9	0.1	-0.4	-0.7
Reaction time mean	0.4	0.8	2.3	0.8	-1.5	-1.1	-0.1	0.5	0.5
Reaction time mean AUC	0.2	0.4	1.0	0.4	-1.0	-0.6	-0.4	0.6	0.7
Median of all reaction times	0.3	0.5	1.2	0.5	-1.1	-0.8	-0.3	0.6	0.6
Reaction time omissions	0.2	0.3	0.8	-0.0	-0.2	0.2	-0.7	0.8	0.9
Reaction time false alarm rate	0.2	0.2	0.4	-0.6	0.3	0.5	-0.5	0.5	0.4
Reaction time premature initiation rate	1.6	2.5	3.2	1.7	-1.2	-1.4	1.8	-1.7	-1.6
Reaction time premature initiations	0.8	2.5	4.2	1.3	-0.5	-1.0	1.9	-2.0	-2.0
Std. dev. reaction times	0.2	0.5	1.5	0.7	-1.2	-0.9	-0.0	0.3	0.4
Reaction time trials completed	0.2	0.6	1.6	-0.9	1.3	0.9	0.1	-0.4	-0.7
Reaction time trials AUC	0.2	0.8	1.9	-0.9	1.4	1.0	0.2	-0.6	-0.8
Run reversals in cocaine runway, females	1.1	1.2	4.0	1.2	-2.0	-1.3	0.3	0.1	0.2
Run reversals in cocaine runway, males	1.1	1.2	3.3	1.4	-1.8	-1.3	0.3	0.1	0.3
Latency to leave start box in cocaine runway	1.0	1.4	2.5	-1.0	0.0	0.7	-1.5	1.6	1.5
Latency to leave start box in cocaine runway, F	2.0	2.4	4.4	-1.2	-0.1	0.9	-2.0	2.1	2.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.1	0.3	0.0	0.4	-0.5	-0.4
Std. dev. time between licks in bursts	0.3	0.6	1.1	0.8	-1.0	-0.4	-0.4	0.7	0.9
Total sessions with >9 infusions	0.5	0.7	1.9	0.1	0.9	1.4	-0.4	0.5	0.9
Short access day 1 total inactive lever presses	0.4	0.9	1.3	1.1	-0.4	-0.9	1.1	-1.0	-0.9
Short access day 10 total inactive lever presses	0.3	2.0	3.3	1.2	-0.2	-0.9	1.8	-1.8	-1.7
Short access day 1 total infusions	0.3	0.6	1.4	0.2	0.9	1.2	-0.3	0.4	0.9
Short access day 10 total infusions	0.1	0.2	0.7	0.1	0.5	0.9	-0.0	0.1	0.3
Short access total infusions	0.8	1.1	3.0	-0.2	1.1	1.7	-0.7	0.7	1.1
Short access day 1 locomotion	0.5	0.8	2.4	1.5	-0.3	-0.5	1.1	-0.8	-0.4
Short access day 10 total locomotion	1.1	4.6	8.2	2.9	-0.9	-1.8	2.6	-2.3	-1.9
Short access total locomotion	0.5	0.8	2.2	1.5	-0.2	-0.3	1.1	-1.0	-0.6
One hour access (0.3 mA shock)	0.1	0.2	0.7	0.0	0.8	0.4	0.2	-0.3	-0.2
Compulsive drug intake	0.0	0.0	0.0	-0.0	-0.2	-0.1	-0.2	0.2	0.2
One hour access (shock baseline)	0.1	0.2	0.5	0.7	0.2	-0.0	0.6	-0.5	-0.3
Social response proportion	0.4	0.5	2.0	0.7	-1.4	-0.8	0.1	0.1	0.0
Social responses	4.8	6.3	16.3	3.0	-4.0	-3.1	1.4	-0.7	-0.5
Social time	0.4	0.6	1.5	-1.1	1.2	0.9	-0.4	0.1	-0.1
Soleus weight	4.2	12.3	20.4	-4.5	4.4	4.4	-2.9	2.1	1.5
Bone: stiffness	3.6	6.5	9.0	-2.8	2.4	3.0	-2.6	2.3	2.1
Tibialis anterior weight	0.9	3.1	5.5	-2.4	2.3	2.1	-1.5	1.0	0.8
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.7	1.1	-1.3	-0.9	0.0	0.3	0.5
Time to tail flick, vehicle, after self-admin	0.8	1.6	2.6	0.7	-0.6	-1.2	1.4	-1.5	-1.6
Time to tail flick, test, before self-admin	0.5	0.6	1.0	0.5	-0.9	-0.6	-0.5	0.8	1.0
Time to tail flick, test, after self-admin	0.2	0.2	0.4	-0.1	-0.1	0.4	-0.5	0.6	0.6
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.5	-1.1	1.1	0.4	0.4	-0.8	-1.2
Delta time to tail flick, test, before/after SA	0.5	0.6	1.6	0.2	0.3	-0.1	0.9	-1.1	-1.3
Tibia length	0.8	2.1	2.9	1.6	-1.7	-1.7	1.4	-1.2	-1.1
Ambulatory time before self-admin	0.1	0.4	0.7	0.8	-0.7	-0.8	0.6	-0.4	-0.3
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	-0.1	0.4	-0.2	0.1	0.1
Bone: tissue strength	4.4	4.6	7.0	-2.4	2.3	2.6	-2.0	1.7	1.6
Total heroin consumption	1.1	1.2	3.5	1.3	-1.9	-1.3	0.6	-0.3	-0.2
Bone: trabecular number	0.4	0.8	1.6	-0.1	-0.9	-0.2	-0.9	1.2	1.3
Bone: trabecular spacing	1.6	2.4	4.9	0.6	0.8	-0.6	1.8	-2.1	-2.2
Bone: trabecular thickness	4.3	5.9	11.7	-1.4	-0.4	1.5	-3.0	3.3	3.4
Bone: trabecular tissue density	2.1	3.6	8.7	-2.3	2.9	2.5	-1.0	0.5	0.3
Water consumed over 24 hours	0.7	1.3	1.7	-1.2	0.7	1.2	-1.3	1.3	1.2
Number of responses in last shaping day	2.2	2.9	6.8	2.6	-0.9	-1.5	1.9	-1.6	-1.1