Suox

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Suox	0.06	0.04	2.5e-05	0.04	0.04	0.03	0.04	2.7e-04	7.0e-05	1.7e-03	8.2e-05
2	PL	mRNA stability	Suox	0.02	0.02	2.7e-03	0.02	0.02	0.01	0.01	2.5e-03	5.6e-03	3.7e-02	7.4e-03
3	PL	gene expression	Suox	0.03	0.02	5.3e-03	0.01	0.01	0	0.01	1.5e-02	2.7e-02	2.5e-01	5.2e-02
4	Adipose	mRNA stability	Suox	0.03	0.02	2.7e-03	0.03	0.01	0.02	0.02	7.4e-04	7.8e-03	3.7e-03	1.2e-03
5	OFC	gene expression	Suox	0.18	0.13	5.0e-03	0.07	0.07	0.04	0.06	1.0e-02	9.9e-03	3.8e-02	1.7e-02
6	Adipose	gene expression	Suox	0.1	0.07	7.8e-08	0.02	0.06	0.06	0.06	3.2e-03	1.5e-07	2.9e-07	5.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.3	2.2	6.0	-0.4	1.1	1.0	-0.7	-2.0	2.4
Area under the delay curve	0.3	0.3	0.5	0.1	-0.3	0.7	-0.7	-0.6	0.6
BMI with tail	6.3	20.4	27.2	5.2	-4.8	5.2	-5.1	-3.7	2.5
BMI without tail	1.1	2.3	3.8	2.0	-1.9	1.7	-1.6	-0.9	0.3
Body weight	1.2	5.1	7.0	2.5	-2.6	2.6	-2.6	-1.7	1.1
Weight adjusted by age	0.1	0.2	0.5	0.1	-0.3	-0.2	0.3	0.6	-0.7
Bone surface	2.2	3.9	10.7	-1.1	2.2	0.6	-0.3	-2.5	3.3
Bone volume	2.4	4.1	11.6	-0.9	2.0	1.0	-0.6	-2.7	3.4
Breakpoint value in progressive ratio session	2.3	2.5	3.6	-1.5	1.2	-1.9	1.8	1.6	-1.3
Number of licking bursts	2.6	3.0	5.9	2.2	-2.4	1.8	-1.9	-0.7	0.1
Context. condit. distance diff. score	0.2	0.2	0.4	0.6	-0.6	0.4	-0.5	-0.3	0.1
Locomotion velocity, session 1	0.9	1.0	2.3	0.1	0.0	0.8	-0.9	-1.4	1.5
Locomotion distance, session 1	0.6	0.8	2.1	-0.7	1.0	0.1	-0.2	-1.1	1.5
Locomotion velocity, session 2	1.2	1.4	3.5	-1.5	1.9	-0.8	0.7	-0.6	1.2
Locomotion distance, session 2	1.5	2.1	5.0	-2.2	2.2	-1.0	1.1	-0.1	0.9
Locomotion velocity, session 3	3.9	4.6	6.2	-2.5	2.1	-2.5	2.4	1.8	-1.3
Locomotion distance, session 3	0.1	0.1	0.1	-0.2	0.0	-0.3	0.3	0.4	-0.4
Stereotopy head waving bouts, day 3	4.7	5.6	8.2	-2.9	2.9	-2.6	2.7	1.6	-0.8
Stereotopy head waving duration, day 3	3.7	4.4	6.8	-2.4	2.6	-2.3	2.5	1.4	-0.7
Locomotion velocity, session 7	0.1	0.1	0.2	-0.4	0.5	-0.3	0.1	-0.2	0.4
Locomotion distance, session 7	0.2	0.2	0.5	0.4	-0.5	-0.0	-0.1	0.5	-0.7
Stereotopy head waving bouts, day 7	0.6	0.7	1.4	-1.1	1.2	-0.5	0.5	-0.3	0.8
Stereotopy head waving duration, day 7	0.5	0.7	1.2	-1.0	1.1	-0.3	0.2	-0.6	1.1
Locomotion velocity, session 8	0.9	1.1	2.2	-1.4	1.5	-0.3	0.3	-0.7	1.2
Locomotion distance, session 8	0.1	0.2	0.6	-0.8	0.6	-0.3	0.3	-0.0	0.3
Degree of sensitization distance	0.5	0.5	0.7	0.8	-0.6	0.8	-0.8	-0.6	0.4
Degree of sensitization stereotypy	0.5	0.6	1.3	0.2	-0.2	0.7	-0.8	-1.1	1.1
Conditioned locomotion	1.0	1.1	2.9	1.4	-1.7	0.7	-0.9	0.3	-0.8
Cocaine response after cond. corrected	1.5	1.7	4.3	1.8	-2.1	0.9	-1.3	-0.1	-0.5
Cocaine response after cond. not corrected	1.6	1.7	4.3	1.9	-2.1	1.0	-1.1	0.0	-0.7
Cocaine response before conditioning	0.4	0.5	1.0	-0.9	1.0	-0.6	0.9	0.4	-0.1
Saline control response	0.3	0.4	0.9	0.8	-0.9	0.7	-0.6	-0.3	0.0
Bone: connectivity density	0.7	1.1	3.2	-0.4	1.0	0.6	-0.4	-1.4	1.8
Bone: cortical apparent density	1.0	1.3	2.0	1.4	-1.2	1.3	-1.2	-0.9	0.6
Bone: cortical area	1.4	2.1	4.2	0.8	-0.1	1.3	-1.3	-2.0	2.1
Bone: cortical porosity	0.2	0.2	0.4	-0.3	0.7	-0.2	0.2	-0.4	0.6
Bone: cortical porosity	0.4	0.4	1.3	0.0	0.5	0.3	-0.3	-1.0	1.1
Bone: cortical thickness	1.3	2.2	2.9	1.4	-0.9	1.6	-1.6	-1.7	1.5
Bone: cortical thickness	0.6	0.7	1.3	1.1	-1.1	0.8	-0.9	-0.3	0.0
Bone: cortical tissue density	0.7	0.9	1.4	1.2	-1.1	1.1	-1.0	-0.7	0.4
Condit. Reinf. active minus inactive responses	1.7	2.0	2.8	-1.6	1.6	-1.7	1.6	1.0	-0.6
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	-0.5	0.5	-0.9	0.9	0.9	-0.8
Condit. Reinf. active responses	2.1	2.6	4.9	-2.1	2.2	-1.8	1.7	0.6	-0.0
Condit. Reinf. inactive responses	1.0	1.1	2.6	-1.5	1.6	-0.9	0.8	-0.1	0.6
Incentive salience index mean	0.9	1.1	2.2	-1.4	1.5	-1.1	0.9	0.2	0.3
Condit. Reinf. lever presses	0.7	1.0	2.7	-0.8	0.8	0.3	-0.4	-1.2	1.6
Condit. Reinf. active minus inactive responses	2.8	3.4	4.6	-1.5	1.4	-2.1	2.2	2.0	-1.8
Condit. Reinf. active-inactive response ratio	1.7	1.8	3.8	-0.4	0.1	-1.3	1.2	1.9	-2.0
Condit. Reinf. active responses	1.7	2.3	3.6	-1.5	1.5	-1.8	1.9	1.3	-0.9
Condit. Reinf. inactive responses	0.3	0.4	0.9	-0.8	1.0	-0.6	0.7	-0.0	0.3
Condit. Reinf. lever presses	3.0	4.0	5.8	-1.9	1.6	-2.1	2.4	2.1	-1.8
Condit. Reinf. lever reinforcers received	1.4	1.9	2.9	-1.2	1.2	-1.6	1.7	1.4	-1.1
Conditioned reinforcement - actives	0.3	0.3	1.0	-0.4	1.0	-0.2	0.5	-0.3	0.5
Conditioned reinforcement - inactives	0.4	0.5	1.4	1.2	-0.9	0.3	0.0	0.3	-0.6
Conditioned locomotion	3.5	4.2	6.9	-2.0	2.6	-2.3	2.6	1.3	-0.7
Patch foraging indifference point 0 sec	2.9	4.6	5.9	2.4	-2.0	2.4	-2.3	-2.1	1.6
Patch foraging indifference point AUC	0.4	0.4	0.7	-0.8	0.7	-0.7	0.6	0.7	-0.5
Delay disc. indifference point, 0s delay	3.4	3.7	5.7	0.9	-0.8	2.2	-2.1	-2.4	2.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.5	0.3	-0.4	0.2	0.1	-0.0
Delay disc. indifference point, 2s delay	0.8	0.9	1.2	0.4	-0.5	1.1	-1.1	-1.1	1.1
Delay disc. indifference point, 24s delay	0.7	0.7	1.2	0.6	-0.8	1.1	-1.0	-0.7	0.5
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	-0.7	0.8	0.0	0.1	-0.5	0.8
Delay disc. indifference point, 8s delay	0.3	0.3	0.6	0.5	-0.8	0.6	-0.4	0.2	-0.4
Indifference point function ln k	0.0	0.1	0.2	0.5	-0.2	0.1	-0.1	-0.2	0.1
Indifference point function log k	0.0	0.1	0.2	0.5	-0.2	0.1	-0.1	-0.2	0.1
Patch foraging total patch changes 0 sec	2.5	4.0	5.6	2.4	-1.9	2.2	-2.2	-1.9	1.4
Patch foraging total patch changes 12 sec	1.3	1.6	2.8	1.7	-1.7	1.5	-1.3	-0.6	0.1
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.2	-0.2	0.2	-0.3	-0.1	0.1
Patch foraging total patch changes 24 sec	0.7	0.9	1.3	0.8	-0.8	1.1	-1.1	-1.0	0.8
Patch foraging total patch changes 6 sec	1.4	2.0	2.9	1.7	-1.3	1.5	-1.6	-1.3	1.0
Patch foraging time to switch 0 sec	0.5	0.8	1.3	0.5	-0.3	1.2	-1.0	-1.1	1.1
Patch foraging water rate 0 sec	0.3	0.5	1.3	1.0	-1.1	0.3	-0.4	0.3	-0.6
Patch foraging water rate 12 sec	0.5	0.7	2.0	1.3	-1.4	0.4	-0.5	0.2	-0.6
Patch foraging water rate 18 sec	1.3	1.8	4.7	0.4	-0.9	-0.9	0.9	1.8	-2.2
Patch foraging water rate 24 sec	1.7	2.4	5.7	1.8	-2.4	0.3	-0.5	1.1	-1.9
Patch foraging water rate 6 sec	1.5	2.2	3.9	-0.5	0.2	-1.7	1.6	1.9	-2.0
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	3.2	-1.5	1.8	-1.2	1.4	0.4	0.1
Distance traveled before self-admin	0.6	0.6	1.2	-1.1	0.9	-0.9	0.8	0.5	-0.2
Distance traveled after self-admin	0.1	0.2	0.4	-0.6	0.6	-0.3	0.5	0.1	0.1
Extensor digitorum longus weight	4.3	16.8	27.1	5.1	-5.2	4.6	-4.4	-2.4	0.9
Bone: elastic displacement	0.0	0.0	0.0	-0.1	0.2	-0.2	0.1	-0.1	0.2
Bone: elastic work	0.8	1.1	1.6	0.8	-0.6	1.1	-1.2	-1.3	1.2
Bone: endosteal estimation	0.6	1.3	2.1	0.9	-0.4	1.1	-1.1	-1.5	1.4
Bone: endosteal perimeter	0.3	0.7	1.7	-0.9	1.3	-0.5	0.5	-0.5	0.9
Epididymis fat weight	0.1	0.2	0.4	-0.3	0.0	-0.4	0.3	0.6	-0.6
Delta time in closed arm before/after self-admin	1.3	1.2	2.9	1.2	-1.4	-0.0	0.1	1.2	-1.7
Delta time in open arm before/after self-admin	2.2	2.2	3.7	1.2	-1.3	1.8	-1.9	-1.4	1.1
Diff in mean of infusions in LGA sessions	2.2	2.5	3.4	-1.6	1.6	-1.8	1.8	1.4	-1.0
Delay discount exponential model param	0.2	0.2	0.4	-0.1	0.3	-0.7	0.6	0.5	-0.5
Extinction: sum of active levers before priming	3.3	3.3	4.8	-1.5	1.0	-2.0	1.9	2.2	-2.0
Active lever presses in extinction session 6	0.6	0.6	1.3	-1.2	0.9	-0.8	0.8	0.4	-0.2
Bone: final force	3.2	5.1	6.8	1.9	-1.3	2.6	-2.5	-2.6	2.4
Bone: final moment	3.0	4.9	6.6	1.9	-1.3	2.5	-2.4	-2.6	2.3
Food consumed during 24 hour testing period	0.4	0.4	0.6	0.7	-0.6	0.8	-0.7	-0.6	0.4
Glucose	1.7	2.5	3.4	1.8	-1.8	1.7	-1.8	-1.2	0.8
Heart weight	0.1	0.1	0.2	0.1	-0.1	-0.2	0.2	0.4	-0.5
Delay discount hyperbolic model param	0.4	0.4	0.7	-0.2	0.4	-0.9	0.8	0.7	-0.7
Intermittent access intake day 1-15 change	1.0	1.0	2.1	-0.6	0.8	-1.2	1.4	0.9	-0.8
Intermittent access intake escalation	1.5	1.5	2.6	-0.2	0.1	-1.3	1.5	1.5	-1.6
Intermittent access intake escalation 2	2.0	2.0	3.0	-0.6	0.4	-1.7	1.7	1.7	-1.7
Intermitt. access day 1 inactive lever presses	1.1	1.2	2.3	-0.0	0.0	-1.1	1.3	1.4	-1.5
Intermitt. access day 15 inactive lever presses	1.7	1.9	2.8	-0.8	0.6	-1.6	1.7	1.6	-1.5
Intermitt. access escalation Index	0.6	0.5	1.2	-0.5	1.1	-0.1	0.2	-0.8	1.1
Intermittent access day 1 total infusions	0.4	0.5	0.9	0.6	-0.3	0.9	-0.7	-0.7	0.7
Intermittent access day 15 total infusions	0.1	0.1	0.1	0.4	-0.1	0.0	0.3	0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.3	0.2	0.3	-0.0	-0.5	0.5
Intermittent access total infusions	0.2	0.2	0.4	0.6	-0.4	0.6	-0.3	-0.4	0.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.1	-0.0	0.2	-0.0	0.0	-0.1
Intermittent access day 15 total locomotion	1.0	1.1	2.3	-0.7	1.0	-1.2	1.5	1.0	-0.8
Intermittent access total locomotion	0.3	0.3	0.5	-0.6	0.7	-0.4	0.7	0.4	-0.2
Intermittent access standard deviation	0.7	0.7	1.4	-0.4	0.6	-0.9	1.2	0.9	-0.8
Left kidney weight	0.4	1.1	2.9	0.1	0.3	0.8	-0.9	-1.5	1.7
Right kidney weight	0.2	0.7	1.6	-1.0	1.3	-0.8	0.8	-0.0	0.4
Cocaine induced anxiety	0.9	1.0	2.4	-1.5	1.5	-0.8	0.8	-0.0	0.5
Post-drug Anxiety	0.8	0.9	2.2	-0.8	1.1	0.2	-0.2	-1.1	1.5
Baseline Anxiety	0.1	0.1	0.2	0.2	-0.3	0.0	0.1	0.3	-0.4
Tail length	4.1	12.4	15.7	-3.7	3.2	-4.0	3.9	3.4	-2.7
Length with tail	1.1	4.1	6.3	-2.5	2.2	-2.3	2.1	1.6	-1.0
Length without tail	0.3	0.7	1.5	0.2	-0.1	0.8	-0.9	-1.2	1.2
Times rat made contact with spout	0.8	0.9	1.7	1.3	-1.3	1.0	-0.9	-0.3	-0.1
Lifetime Intake	0.6	0.7	1.0	0.9	-0.5	1.0	-0.7	-1.0	0.8
Liver weight, left	0.9	1.4	2.9	1.7	-1.5	1.2	-1.3	-0.6	0.2
Liver weight, right	0.7	1.1	1.6	1.3	-0.8	1.2	-1.2	-1.0	0.8
Locomotor activity	2.2	3.5	6.6	-2.5	2.6	-1.9	1.9	0.9	-0.2
Locomotor testing distance	0.9	1.5	3.0	-1.6	1.7	-1.3	1.3	0.5	-0.1
Locomotor testing rearing	0.0	0.1	0.2	0.1	-0.2	-0.1	0.1	0.3	-0.4
Locomotion in novel chamber	0.1	0.1	0.2	0.5	-0.3	0.4	-0.2	-0.2	0.1
Locomotion in novel chamber post-restriction	2.8	3.4	4.6	-2.1	2.0	-2.1	1.9	1.5	-1.0
Fecal boli incidents, locomotor time 1	0.7	0.7	1.9	1.1	-1.4	0.7	-0.7	0.2	-0.6
Change in fecal boli incidents, locomotor task	0.6	0.6	1.3	-0.9	1.2	-0.3	0.3	-0.6	1.0
Time >=10cm from walls, locomotor time 1	1.1	1.1	2.0	0.6	-0.3	1.1	-1.1	-1.4	1.4
Bouts of movement, locomotor time 1	0.5	0.5	0.7	-0.7	0.7	-0.8	0.9	0.8	-0.6
Total resting periods, locomotor time 1	0.9	1.0	1.3	-1.2	1.1	-1.1	1.1	0.9	-0.6
Rest time, locomotor task time 1	0.2	0.3	0.6	-0.8	0.7	-0.5	0.5	0.2	0.1
Distance moved, locomotor task time 1	1.0	1.1	2.0	0.6	-0.2	1.0	-1.0	-1.4	1.4
Vertical activity count, locomotor time 1	0.6	0.6	1.3	1.1	-0.9	0.7	-0.7	-0.5	0.2
Time >=10cm from walls, locomotor time 2	0.7	0.8	1.5	1.2	-1.2	1.0	-0.8	-0.3	0.0
Bouts of movement, locomotor time 2	0.3	0.4	0.8	-0.7	0.9	-0.1	0.2	-0.4	0.8
Total resting periods, locomotor time 2	0.4	0.4	0.9	-0.7	0.9	-0.0	0.2	-0.6	0.9
Rest time, locomotor task time 2	0.2	0.2	0.6	-0.3	0.4	0.2	-0.2	-0.6	0.8
Distance moved, locomotor task time 2	0.2	0.2	0.6	0.3	-0.4	-0.2	0.2	0.6	-0.8
Vertical activity count, locomotor time 2	1.0	1.0	2.5	1.4	-1.6	0.7	-0.8	0.1	-0.6
Light reinforcement 1	3.2	5.9	8.4	-2.7	2.7	-2.9	2.9	1.7	-1.0
Light reinforcement 2	1.0	1.3	1.9	-1.2	1.2	-1.4	1.4	0.8	-0.5
Bone: marrow area	0.5	1.1	1.9	0.9	-0.4	1.1	-1.1	-1.4	1.3
Bone: maximum diameter	0.5	1.0	2.4	-1.0	1.5	-0.5	0.5	-0.8	1.2
Bone: maximum force	3.1	5.3	6.8	2.1	-1.5	2.6	-2.5	-2.6	2.3
Bone: maximum moment	3.0	5.1	6.6	2.0	-1.5	2.5	-2.5	-2.6	2.3
Mean time between licks in bursts	1.1	1.5	2.1	-1.1	1.0	-1.4	1.4	1.3	-1.1
Mean num. licks in bursts	0.6	0.7	1.4	-1.0	1.2	-0.9	0.9	0.5	-0.2
Cd content in liver	0.4	0.4	0.7	0.6	-0.6	0.9	-0.8	-0.6	0.4
Co content in liver	1.3	1.5	2.1	-1.1	0.9	-1.2	1.4	1.4	-1.3
Cu content in liver	1.3	1.5	2.9	0.8	-0.3	1.1	-1.2	-1.7	1.7
Fe content in liver	0.3	0.4	0.7	0.8	-0.9	0.8	-0.5	-0.1	-0.2
K content in liver	0.5	0.5	1.3	-0.9	1.2	-0.4	0.6	-0.2	0.6
Mg content in liver	0.5	0.5	0.9	-0.8	1.0	0.1	0.1	-0.6	1.0
Mn content in liver	1.5	1.7	4.2	-1.1	1.6	0.2	0.1	-1.5	2.0
Na content in liver	0.3	0.4	0.7	0.2	-0.2	0.6	-0.6	-0.8	0.8
Rb content in liver	0.8	1.0	2.4	0.5	0.2	0.9	-0.6	-1.4	1.6
Se content in liver	0.0	0.0	0.1	-0.3	0.3	0.1	0.1	-0.1	0.1
Sr content in liver	1.1	1.0	2.2	-0.2	0.1	-1.0	0.9	1.4	-1.5
Zn content in liver	2.9	3.2	5.8	-1.1	0.6	-1.8	1.8	2.4	-2.4
Bone: minimum diameter	0.4	0.8	2.0	0.3	0.2	0.8	-0.7	-1.3	1.4
Time in familiar zone, hab. session 1	4.5	4.2	5.4	-2.2	1.8	-2.3	2.3	2.1	-1.6
Time in novel zone, hab. session 1	4.1	4.0	5.7	1.7	-1.2	2.2	-2.1	-2.4	2.2
Total zone transitions, hab. session 1	0.4	0.6	1.1	-1.0	1.1	-0.1	0.1	-0.7	1.1
Total locomotion distance, hab. session 1	1.4	2.0	4.6	-1.9	2.1	-0.7	0.8	-0.7	1.4
Locomotion velocity, hab. session 1	1.3	1.8	4.3	-1.9	2.1	-1.0	1.0	-0.3	0.9
Time in familiar zone, hab. session 2	5.5	5.7	7.5	-2.2	1.9	-2.7	2.7	2.5	-2.1
Time in novel zone, hab. session 2	6.1	6.1	7.8	2.2	-1.8	2.8	-2.8	-2.7	2.4
Total zone transitions, hab. session 2	1.5	2.0	4.5	0.4	-0.1	1.2	-1.3	-2.0	2.1
Total locomotion distance, hab. session 2	0.3	0.5	1.0	-0.8	0.8	-0.1	-0.0	-0.7	1.0
Locomotion velocity, hab. session 2	0.5	0.7	1.7	-0.9	1.0	-0.0	-0.1	-0.9	1.3
Novel to familiar place preference ratio	3.8	3.9	5.8	1.5	-1.1	2.1	-2.2	-2.4	2.2
Novelty place preference	2.7	2.7	4.3	1.2	-0.8	1.7	-1.8	-2.1	2.0
Time in novel zone, NPP test	3.1	3.2	4.7	1.4	-1.0	1.9	-1.9	-2.2	2.0
Total zone transitions, NPP test	0.8	1.1	1.7	0.5	-0.5	1.2	-1.2	-1.3	1.3
Total locomotion distance, NPP test	0.6	0.8	2.0	-0.0	0.1	0.7	-0.8	-1.2	1.4
Locomotion velocity, NPP test	0.3	0.5	1.4	-0.3	0.4	0.4	-0.5	-1.0	1.2
Intraocular pressure	0.8	1.1	2.7	-0.4	-0.2	-1.0	0.8	1.5	-1.6
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.1	0.1	0.3	-0.0	-0.3	0.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.6	0.1	0.3	0.5	-0.3	-0.7	0.8
Parametrial fat weight	0.1	0.2	0.3	-0.2	0.2	-0.4	0.5	0.5	-0.5
Pavlov. Cond. lever latency	0.3	0.4	1.3	0.4	-0.5	-0.1	0.3	0.9	-1.1
Pavlov. Cond. magazine entry latency	1.4	1.8	2.7	-1.5	1.2	-1.6	1.5	1.3	-1.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.3	-0.3	0.3	-0.4	-0.4	0.4
Pavlov. Cond. index score	0.3	0.4	0.8	-0.9	0.8	-0.5	0.4	-0.1	0.4
Pavlov. Cond. latency score	0.4	0.5	1.0	-1.0	1.0	-0.5	0.3	-0.4	0.7
Pavlov. Cond. lever contacts	0.6	0.7	2.1	-0.3	0.4	0.5	-0.6	-1.2	1.5
Pavlov. Cond. magazine entry number	0.4	0.5	0.8	0.9	-0.7	0.8	-0.7	-0.5	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.0	-0.0	-0.1	-0.6	0.5	0.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	-1.0	1.0	-0.7	0.5	0.0	0.3
Pavlov. Cond. response bias	0.4	0.5	1.0	-1.0	0.7	-0.9	0.7	0.5	-0.3
Pavlov. Cond. lever latency	1.2	1.6	2.4	1.5	-1.4	1.2	-1.5	-1.0	0.7
Pavlov. Cond. magazine entry latency	1.9	2.2	3.3	-1.8	1.8	-1.5	1.7	1.1	-0.6
Pavlov. Cond. change in total contacts	0.8	1.1	1.6	-1.1	1.1	-1.0	1.3	0.9	-0.7
Pavlov. Cond. index score	1.9	2.4	3.3	-1.7	1.7	-1.6	1.8	1.3	-0.9
Pavlov. Cond. latency score	1.7	2.2	3.2	-1.8	1.8	-1.5	1.7	1.1	-0.7
Pavlov. Cond. lever contacts	1.2	1.7	2.3	-1.4	1.2	-1.3	1.5	1.3	-1.0
Pavlov. Cond. magazine entry number	1.8	2.2	3.4	1.8	-1.8	1.6	-1.7	-1.1	0.6
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.8	1.3	-1.4	0.9	-0.8	-0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.5	3.4	-1.8	1.8	-1.6	1.8	1.2	-0.8
Pavlov. Cond. response bias	2.1	2.8	3.9	-1.8	1.6	-1.8	2.0	1.6	-1.3
Time in closed arm before self-admin	0.8	0.9	2.0	0.2	0.1	0.9	-0.9	-1.3	1.4
Time in closed arm after self-admin	0.1	0.1	0.2	0.5	-0.2	0.2	-0.0	-0.3	0.2
Time in open arm before self-admin	1.2	1.3	2.4	-0.6	0.8	-1.4	1.6	1.1	-1.0
Time in open arm after self-admin	0.9	1.0	1.6	1.2	-1.3	1.1	-1.2	-0.5	0.1
Bone: periosteal estimation	1.3	2.8	5.3	1.0	-0.3	1.6	-1.6	-2.3	2.3
Bone: periosteal perimeter	0.5	0.9	2.5	-0.3	0.9	0.3	-0.3	-1.3	1.6
Bone: post-yield work	0.3	0.3	0.5	0.7	-0.5	0.6	-0.6	-0.5	0.4
Progressive ratio test 1 active lever presses	0.8	0.9	1.5	1.2	-0.9	1.2	-0.9	-0.7	0.4
Progressive ratio test 1 breakpoint	1.0	1.0	1.8	1.3	-0.9	1.3	-1.0	-0.8	0.6
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.8	-0.2	0.8	-0.6	0.9	0.2	0.0
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	0.7	-0.3	0.6	-0.3	-0.5	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	0.2	0.3	0.4	-0.1	-0.6	0.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.3	0.2	0.4	-0.0	-0.6	0.6
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.4	0.5	-0.6	0.6	0.3	-0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	-0.5	0.7	-0.7	0.7	0.2	-0.0
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.5	0.5	-0.6	0.6	0.5	-0.4
Progressive ratio	0.7	0.8	1.6	1.3	-1.1	0.9	-0.8	-0.5	0.2
Food seeking constrained by brief footshock	0.9	1.2	2.0	-1.4	1.0	-1.2	1.0	1.0	-0.7
Seeking ratio, punishment vs. effort	1.4	1.7	3.0	-1.7	1.3	-1.5	1.2	1.1	-0.8
Retroperitoneal fat weight	1.8	6.0	9.5	3.1	-3.0	2.7	-2.6	-1.6	0.9
Reaction time number correct	0.8	1.1	2.9	1.4	-1.7	0.8	-1.0	-0.0	-0.4
Reaction time mean minus median	0.9	1.2	2.1	-1.4	1.3	-1.2	1.2	0.8	-0.4
Reaction time mean minus median AUC	1.0	1.3	3.1	-1.6	1.7	-0.7	0.7	-0.3	0.9
Reaction time num false alarms	0.5	0.6	1.2	1.0	-1.1	0.9	-0.7	-0.4	0.1
Reaction time num false alarms AUC	0.5	0.7	1.8	1.2	-1.4	0.9	-0.7	-0.2	-0.2
Reaction time trials correct on left	0.8	1.1	2.9	1.4	-1.7	0.8	-1.0	-0.0	-0.4
Reaction time trials on left	0.7	1.0	2.7	1.3	-1.6	0.9	-1.0	-0.1	-0.4
Reaction time mean	0.6	0.9	2.2	-1.5	1.4	-0.7	0.7	0.1	0.4
Reaction time mean AUC	0.3	0.5	1.1	-1.0	1.0	-0.3	0.3	-0.3	0.6
Median of all reaction times	0.3	0.5	1.1	-1.1	1.1	-0.3	0.3	-0.2	0.5
Reaction time omissions	0.1	0.1	0.2	-0.1	0.3	0.0	0.0	-0.3	0.4
Reaction time false alarm rate	0.1	0.2	0.4	0.4	-0.4	0.6	-0.4	-0.4	0.3
Reaction time premature initiation rate	1.9	2.5	3.5	-1.2	1.0	-1.8	1.7	1.9	-1.7
Reaction time premature initiations	1.4	1.9	4.1	-0.4	0.0	-1.4	1.3	1.9	-2.0
Std. dev. reaction times	0.5	0.7	1.5	-1.2	1.2	-0.6	0.8	0.2	0.2
Reaction time trials completed	0.7	1.0	2.7	1.3	-1.6	0.9	-1.0	-0.1	-0.4
Reaction time trials AUC	0.9	1.2	3.3	1.5	-1.8	0.9	-1.0	0.0	-0.5
Run reversals in cocaine runway, females	1.3	1.3	2.8	-1.5	1.7	-1.1	1.0	0.5	-0.1
Run reversals in cocaine runway, males	2.0	2.0	4.0	-1.8	2.0	-1.5	1.4	0.7	-0.1
Latency to leave start box in cocaine runway	1.0	1.1	2.8	0.1	0.0	1.0	-0.8	-1.5	1.7
Latency to leave start box in cocaine runway, F	2.0	2.2	5.5	0.0	0.2	1.3	-1.3	-2.1	2.3
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	0.3	-0.5	-0.1	0.4	0.7	-0.9
Std. dev. time between licks in bursts	0.6	0.8	1.8	-1.0	1.3	-0.8	0.6	-0.3	0.8
Total sessions with >9 infusions	0.7	0.8	2.3	0.1	0.8	0.4	-0.2	-1.3	1.5
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.0	0.4	-0.3	0.4	0.0	0.1
Short access day 10 total inactive lever presses	0.5	0.6	1.1	0.1	-0.0	-0.8	0.9	0.9	-1.0
Short access day 1 total infusions	1.1	1.2	3.1	0.5	0.5	0.7	-0.6	-1.6	1.8
Short access day 10 total infusions	0.4	0.4	0.8	0.8	-0.3	0.9	-0.5	-0.7	0.6
Short access total infusions	1.5	1.7	3.1	1.1	-0.2	1.4	-1.1	-1.8	1.7
Short access day 1 locomotion	0.3	0.3	1.0	-0.4	1.0	-0.1	0.5	-0.3	0.5
Short access day 10 total locomotion	3.0	3.4	5.8	-1.4	1.5	-2.1	2.4	1.8	-1.5
Short access total locomotion	0.4	0.4	1.0	-0.6	1.0	-0.5	0.9	0.2	0.0
One hour access (0.3 mA shock)	0.3	0.3	0.6	0.7	-0.6	0.8	-0.5	-0.5	0.3
Compulsive drug intake	0.4	0.4	0.7	0.5	-0.6	0.8	-0.7	-0.5	0.4
One hour access (shock baseline)	0.1	0.1	0.3	0.3	-0.2	-0.2	0.4	0.4	-0.5
Social response proportion	0.4	0.4	1.1	-1.0	0.9	-0.7	0.4	0.2	0.2
Social responses	6.2	7.9	13.4	-3.7	3.5	-3.1	3.0	1.7	-0.7
Social time	1.0	1.3	2.0	1.4	-1.4	1.2	-1.4	-0.7	0.3
Soleus weight	5.5	16.2	21.4	4.6	-4.5	4.5	-4.6	-3.2	2.1
Bone: stiffness	4.2	6.7	8.7	2.6	-2.1	3.0	-2.9	-2.7	2.2
Tibialis anterior weight	1.2	4.1	5.5	2.2	-2.2	2.3	-2.3	-1.6	1.1
Time to tail flick, vehicle, before self-admin	1.8	1.8	4.5	-1.6	2.1	-1.3	1.2	-0.3	0.9
Time to tail flick, vehicle, after self-admin	0.6	0.7	1.4	-0.3	-0.0	-0.9	0.8	1.1	-1.2
Time to tail flick, test, before self-admin	0.9	0.9	2.3	-1.2	1.5	-0.6	0.8	-0.3	0.8
Time to tail flick, test, after self-admin	0.4	0.4	0.9	-0.5	0.8	0.1	0.1	-0.7	1.0
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	4.0	1.3	-2.0	0.9	-1.0	0.5	-1.1
Delta time to tail flick, test, before/after SA	0.3	0.2	0.7	-0.0	-0.3	-0.4	0.2	0.7	-0.8
Tibia length	0.7	2.1	2.7	-1.6	1.3	-1.5	1.6	1.5	-1.2
Ambulatory time before self-admin	0.2	0.2	0.4	-0.5	0.4	-0.7	0.4	0.3	-0.2
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	0.3	-0.0	0.1	-0.1	0.2
Bone: tissue strength	3.7	3.6	4.4	2.0	-1.7	2.1	-2.1	-1.9	1.5
Total heroin consumption	1.6	1.8	3.2	-1.8	1.6	-1.5	1.4	0.9	-0.4
Bone: trabecular number	0.7	1.0	2.6	-1.3	1.6	-0.1	0.4	-0.7	1.2
Bone: trabecular spacing	1.4	1.8	5.0	0.9	-1.4	-0.5	0.4	1.7	-2.2
Bone: trabecular thickness	3.4	4.0	11.4	-0.4	1.3	1.3	-1.1	-2.8	3.4
Bone: trabecular tissue density	3.9	5.6	9.7	3.1	-3.0	2.6	-2.4	-1.3	0.5
Water consumed over 24 hours	1.2	1.4	2.5	0.8	-0.3	1.3	-1.1	-1.6	1.6
Number of responses in last shaping day	1.6	1.7	3.0	-1.1	1.5	-1.6	1.7	0.9	-0.6