Suox

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	isoform ratio	NM_031127.4	0.02	0.02	6.7e-03	0.02	0.01	0	0.01	5.5e-03	3.3e-02	1.6e-01	4.0e-02
2	Brain	mRNA stability	Suox	0.04	0.03	6.2e-04	0.03	0.03	0.03	0.03	3.7e-04	6.2e-04	3.8e-04	3.4e-04
3	PL	gene expression	Suox	0.03	0.02	4.1e-03	0.02	0.02	0.01	0.02	3.8e-03	4.7e-03	1.7e-02	5.2e-03
4	OFC	gene expression	Suox	0.18	0.13	9.5e-03	0.03	0.05	0.01	0.04	7.4e-02	2.8e-02	2.2e-01	3.7e-02
5	Adipose	gene expression	Suox	0.09	0.06	4.0e-07	0.02	0.06	0.06	0.05	5.0e-03	4.1e-07	9.1e-07	1.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.4	2.5	5.6	1.1	-0.1	-1.0	-2.1	2.4
Area under the delay curve	0.1	0.1	0.3	0.5	0.1	-0.3	-0.4	0.4
BMI with tail	6.2	21.3	30.8	5.5	5.5	-5.3	-3.3	2.3
BMI without tail	1.7	5.2	7.8	2.8	2.7	-2.8	-1.5	1.0
Body weight	0.8	3.5	6.0	2.5	2.3	-2.2	-1.0	0.4
Weight adjusted by age	0.1	0.1	0.3	-0.3	-0.1	0.5	0.4	-0.4
Bone surface	2.0	3.7	9.8	0.7	-0.9	-0.9	-2.6	3.1
Bone volume	2.5	4.4	11.0	1.1	-0.7	-1.1	-2.9	3.3
Breakpoint value in progressive ratio session	0.9	1.1	1.8	-1.3	-1.1	1.1	1.0	-0.8
Number of licking bursts	1.3	2.2	4.6	1.9	2.1	-1.5	-0.5	0.0
Context. condit. distance diff. score	0.1	0.2	0.4	0.4	0.6	-0.3	-0.3	0.2
Locomotion velocity, session 1	1.1	1.2	2.4	1.0	-0.1	-0.7	-1.5	1.5
Locomotion distance, session 1	0.6	0.8	2.1	0.2	-0.7	-0.1	-1.2	1.4
Locomotion velocity, session 2	0.9	1.0	2.1	-0.7	-1.4	0.8	-0.7	1.2
Locomotion distance, session 2	1.3	1.8	5.7	-1.0	-2.4	1.2	-0.3	0.8
Locomotion velocity, session 3	3.8	4.3	6.2	-2.4	-2.5	2.4	1.6	-1.2
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	-0.4	0.3	0.4	-0.4
Stereotopy head waving bouts, day 3	3.7	4.4	7.1	-2.5	-2.7	2.4	1.3	-0.8
Stereotopy head waving duration, day 3	2.8	3.3	5.6	-2.4	-2.1	2.2	1.2	-0.7
Locomotion velocity, session 7	0.1	0.1	0.1	-0.2	-0.3	0.2	-0.3	0.4
Locomotion distance, session 7	0.1	0.2	0.5	-0.0	0.4	0.0	0.5	-0.7
Stereotopy head waving bouts, day 7	0.5	0.6	1.4	-0.4	-1.2	0.6	-0.5	0.8
Stereotopy head waving duration, day 7	0.6	0.7	1.4	-0.3	-1.2	0.4	-0.8	1.1
Locomotion velocity, session 8	0.8	1.0	2.5	-0.3	-1.6	0.6	-0.8	1.2
Locomotion distance, session 8	0.2	0.2	0.7	-0.4	-0.9	0.5	-0.1	0.2
Degree of sensitization distance	0.5	0.5	0.8	0.8	0.9	-0.8	-0.6	0.5
Degree of sensitization stereotypy	0.6	0.6	1.2	0.7	0.1	-0.4	-1.1	1.1
Conditioned locomotion	0.6	0.6	1.6	0.6	1.2	-0.6	0.5	-0.9
Cocaine response after cond. corrected	1.1	1.4	3.9	1.2	2.0	-1.1	0.0	-0.4
Cocaine response after cond. not corrected	1.2	1.4	3.9	1.1	2.0	-1.2	0.2	-0.6
Cocaine response before conditioning	0.3	0.4	0.9	-0.8	-1.0	0.5	0.3	-0.2
Saline control response	0.3	0.4	0.7	0.8	0.8	-0.6	0.0	-0.3
Bone: connectivity density	0.7	1.1	2.7	0.7	-0.1	-0.7	-1.4	1.6
Bone: cortical apparent density	0.9	1.3	2.1	1.2	1.5	-1.1	-1.0	0.8
Bone: cortical area	1.8	2.8	4.5	1.4	0.8	-1.6	-2.1	2.1
Bone: cortical porosity	0.2	0.2	0.5	0.1	-0.0	-0.4	-0.6	0.7
Bone: cortical porosity	0.6	0.7	1.5	0.5	0.2	-0.7	-1.1	1.2
Bone: cortical thickness	1.9	3.2	4.1	1.7	1.5	-2.0	-1.9	1.8
Bone: cortical thickness	0.5	0.5	1.1	0.8	1.1	-0.9	-0.2	-0.0
Bone: cortical tissue density	0.7	0.9	1.5	1.0	1.2	-0.9	-0.8	0.7
Condit. Reinf. active minus inactive responses	1.6	1.8	3.2	-1.6	-1.4	1.8	0.9	-0.6
Condit. Reinf. active-inactive response ratio	0.6	0.7	0.9	-1.0	-0.3	1.0	0.9	-0.8
Condit. Reinf. active responses	1.8	2.2	3.9	-1.7	-2.0	2.0	0.5	-0.0
Condit. Reinf. inactive responses	0.8	1.0	2.8	-0.8	-1.7	1.0	-0.3	0.6
Incentive salience index mean	0.8	0.9	1.8	-1.0	-1.4	1.3	0.1	0.3
Condit. Reinf. lever presses	0.6	0.9	2.1	0.2	-0.9	0.1	-1.2	1.5
Condit. Reinf. active minus inactive responses	3.0	3.9	5.0	-2.2	-1.6	2.0	2.1	-1.9
Condit. Reinf. active-inactive response ratio	2.2	2.5	4.2	-1.4	-0.6	1.4	2.0	-2.1
Condit. Reinf. active responses	1.6	2.2	3.4	-1.8	-1.5	1.5	1.3	-1.0
Condit. Reinf. inactive responses	0.2	0.2	0.5	-0.5	-0.7	0.3	-0.1	0.3
Condit. Reinf. lever presses	2.7	3.7	4.7	-2.2	-1.8	2.0	1.9	-1.6
Condit. Reinf. lever reinforcers received	1.4	2.0	2.9	-1.7	-1.3	1.4	1.4	-1.2
Conditioned reinforcement - actives	0.2	0.3	0.6	-0.6	0.8	-0.4	0.3	-0.2
Conditioned reinforcement - inactives	0.4	0.5	1.5	-0.5	1.2	-0.4	0.6	-0.6
Conditioned locomotion	1.5	1.9	5.8	-2.4	-1.1	1.2	1.0	-0.4
Patch foraging indifference point 0 sec	3.1	5.8	8.9	2.5	2.6	-3.0	-2.1	1.7
Patch foraging indifference point AUC	0.8	1.1	2.1	-1.1	-0.9	1.4	0.9	-0.7
Delay disc. indifference point, 0s delay	3.8	4.2	6.1	2.2	0.9	-2.0	-2.5	2.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.3	-0.6	0.5	-0.0	0.1
Delay disc. indifference point, 2s delay	0.9	1.0	1.5	1.1	0.3	-0.8	-1.2	1.1
Delay disc. indifference point, 24s delay	0.4	0.4	0.7	0.8	0.4	-0.9	-0.6	0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	0.1	-0.7	0.0	-0.6	0.8
Delay disc. indifference point, 8s delay	0.1	0.2	0.4	0.4	0.6	-0.2	0.2	-0.4
Indifference point function ln k	0.0	0.1	0.2	0.0	0.5	-0.4	-0.0	0.0
Indifference point function log k	0.0	0.1	0.2	0.0	0.5	-0.4	-0.0	0.0
Patch foraging total patch changes 0 sec	2.7	5.0	7.8	2.3	2.4	-2.8	-1.9	1.6
Patch foraging total patch changes 12 sec	1.1	1.5	2.9	1.4	1.7	-1.4	-0.6	0.3
Patch foraging total patch changes 18 sec	0.1	0.1	0.1	0.3	0.1	-0.3	-0.4	0.3
Patch foraging total patch changes 24 sec	0.5	0.9	1.2	1.0	0.6	-1.1	-1.0	0.9
Patch foraging total patch changes 6 sec	1.5	2.3	3.0	1.6	1.7	-1.6	-1.4	1.2
Patch foraging time to switch 0 sec	0.5	1.1	1.5	1.1	0.4	-1.1	-1.2	1.2
Patch foraging water rate 0 sec	0.2	0.5	1.2	0.4	1.1	-0.6	0.4	-0.6
Patch foraging water rate 12 sec	0.3	0.6	1.7	0.4	1.3	-0.9	0.4	-0.6
Patch foraging water rate 18 sec	1.4	2.2	5.2	-0.9	0.5	0.8	2.0	-2.3
Patch foraging water rate 24 sec	1.4	1.9	3.6	0.4	1.9	-0.6	1.4	-1.9
Patch foraging water rate 6 sec	1.7	2.5	4.2	-1.6	-0.3	1.1	2.0	-2.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.8	1.9	-1.4	-1.1	0.9	0.3	0.0
Distance traveled before self-admin	1.1	1.4	2.3	-1.3	-1.4	1.5	0.8	-0.6
Distance traveled after self-admin	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.0	-0.0
Extensor digitorum longus weight	3.3	13.1	25.1	4.4	5.0	-4.1	-1.9	0.9
Bone: elastic displacement	0.0	0.0	0.1	-0.0	0.1	-0.4	-0.1	0.2
Bone: elastic work	1.3	1.7	2.2	1.3	0.9	-1.5	-1.4	1.3
Bone: endosteal estimation	0.7	1.4	1.7	1.1	0.9	-1.3	-1.3	1.3
Bone: endosteal perimeter	0.2	0.4	0.9	-0.5	-0.9	0.4	-0.5	0.8
Epididymis fat weight	0.3	1.0	2.0	-0.8	0.1	0.9	1.3	-1.4
Delta time in closed arm before/after self-admin	1.4	1.3	2.9	0.1	1.7	-0.3	1.1	-1.5
Delta time in open arm before/after self-admin	0.9	0.9	1.8	1.3	0.8	-1.2	-0.7	0.5
Diff in mean of infusions in LGA sessions	1.7	2.1	3.1	-1.8	-1.5	1.6	1.3	-1.0
Delay discount exponential model param	0.1	0.1	0.2	-0.4	0.0	0.2	0.3	-0.3
Extinction: sum of active levers before priming	2.2	2.4	2.9	-1.7	-1.0	1.6	1.7	-1.6
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.3	-0.5	0.3	-0.0	0.1
Bone: final force	4.0	6.5	7.7	2.6	1.8	-2.8	-2.8	2.6
Bone: final moment	4.0	6.4	7.7	2.6	1.8	-2.7	-2.8	2.6
Food consumed during 24 hour testing period	0.3	0.4	0.7	0.8	0.6	-0.7	-0.5	0.4
Glucose	1.1	1.8	2.9	1.7	1.3	-1.6	-1.0	0.7
Heart weight	0.6	0.9	1.2	-1.0	-0.3	1.0	1.1	-1.0
Delay discount hyperbolic model param	0.4	0.4	0.6	-0.8	-0.2	0.6	0.8	-0.7
Intermittent access intake day 1-15 change	0.8	1.7	3.1	-1.8	-0.3	1.0	1.5	-1.4
Intermittent access intake escalation	0.8	1.6	2.8	-1.7	-0.3	0.9	1.5	-1.4
Intermittent access intake escalation 2	1.1	1.3	2.2	-1.5	-0.8	1.1	1.2	-1.0
Intermitt. access day 1 inactive lever presses	0.6	2.3	3.8	-1.4	-0.5	1.2	1.9	-2.0
Intermitt. access day 15 inactive lever presses	0.6	1.2	1.6	-1.3	-1.0	1.1	1.1	-1.0
Intermitt. access escalation Index	0.4	0.6	1.1	0.5	-0.3	-0.7	-1.0	1.0
Intermittent access day 1 total infusions	0.1	0.2	0.8	0.0	0.6	-0.9	0.0	-0.1
Intermittent access day 15 total infusions	0.1	0.2	0.5	-0.7	0.2	-0.5	0.3	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	-0.6	-0.1	-0.6	-0.1	0.3
Intermittent access total infusions	0.2	0.3	0.9	-0.2	0.6	-0.9	-0.1	0.2
Intermittent access day 1 locomotion	0.2	0.3	0.6	-0.3	0.5	-0.4	0.7	-0.7
Intermittent access day 15 total locomotion	0.6	1.0	2.4	-1.6	0.1	0.3	1.2	-1.1
Intermittent access total locomotion	0.3	0.4	0.8	-0.9	0.2	-0.1	0.7	-0.6
Intermittent access standard deviation	0.5	0.9	2.7	-1.6	-1.0	0.7	0.6	-0.2
Left kidney weight	0.0	0.0	0.1	0.0	0.1	0.1	0.3	-0.3
Right kidney weight	0.2	0.8	1.2	-0.7	-0.5	1.1	1.0	-0.9
Cocaine induced anxiety	0.7	1.0	2.7	-1.0	-1.7	1.0	-0.2	0.6
Post-drug Anxiety	0.9	0.9	1.9	-0.3	-1.3	0.1	-1.0	1.4
Baseline Anxiety	0.0	0.0	0.0	0.1	0.0	-0.2	-0.1	0.1
Tail length	2.9	11.5	14.8	-3.8	-3.8	3.8	2.9	-2.3
Length with tail	1.5	6.6	8.0	-2.8	-2.5	2.8	2.5	-2.2
Length without tail	0.1	0.3	0.9	0.6	0.9	-0.6	0.0	-0.2
Times rat made contact with spout	0.6	0.7	1.5	1.0	1.2	-1.0	-0.1	-0.2
Lifetime Intake	0.7	0.9	2.5	0.2	1.1	-1.6	-0.5	0.6
Liver weight, left	0.3	0.6	1.1	0.9	1.1	-0.7	-0.4	0.3
Liver weight, right	0.2	0.3	0.5	-0.2	-0.4	0.6	0.6	-0.7
Locomotor activity	1.9	2.9	6.5	-1.8	-2.6	2.0	0.6	-0.1
Locomotor testing distance	0.8	1.4	3.0	-1.4	-1.7	1.5	0.4	0.0
Locomotor testing rearing	0.0	0.1	0.2	-0.1	-0.1	0.2	0.4	-0.4
Locomotion in novel chamber	0.0	0.0	0.1	-0.0	0.1	-0.3	-0.1	0.1
Locomotion in novel chamber post-restriction	2.9	4.7	7.3	-2.5	-2.7	2.5	1.6	-1.1
Fecal boli incidents, locomotor time 1	0.3	0.4	0.8	0.9	0.8	-0.7	0.1	-0.4
Change in fecal boli incidents, locomotor task	0.6	0.5	1.2	-0.4	-1.1	0.4	-0.6	0.9
Time >=10cm from walls, locomotor time 1	1.3	1.4	2.2	1.0	0.4	-1.2	-1.5	1.5
Bouts of movement, locomotor time 1	0.8	0.9	1.4	-1.0	-0.8	1.2	0.9	-0.7
Total resting periods, locomotor time 1	1.3	1.4	2.1	-1.3	-1.3	1.5	1.0	-0.8
Rest time, locomotor task time 1	0.3	0.4	1.3	-0.5	-1.1	0.5	0.0	0.2
Distance moved, locomotor task time 1	1.2	1.7	2.7	1.1	0.9	-1.2	-1.6	1.6
Vertical activity count, locomotor time 1	0.5	1.1	3.2	0.8	1.8	-1.0	-0.6	0.4
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.4	0.8	1.2	-1.0	-0.2	-0.1
Bouts of movement, locomotor time 2	0.2	0.3	0.6	-0.1	-0.7	0.2	-0.6	0.8
Total resting periods, locomotor time 2	0.2	0.4	0.9	-0.0	-0.8	0.1	-0.7	1.0
Rest time, locomotor task time 2	0.3	0.3	0.6	0.1	-0.8	-0.2	-0.6	0.8
Distance moved, locomotor task time 2	0.2	0.3	0.6	-0.3	0.6	0.1	0.7	-0.7
Vertical activity count, locomotor time 2	0.6	0.8	2.7	0.7	1.6	-0.7	0.3	-0.7
Light reinforcement 1	1.8	4.5	8.3	-2.9	-2.7	2.1	1.4	-0.8
Light reinforcement 2	0.7	1.0	1.8	-1.3	-1.3	0.9	0.7	-0.5
Bone: marrow area	0.6	1.3	1.5	1.0	0.9	-1.2	-1.2	1.2
Bone: maximum diameter	0.3	0.6	1.2	-0.5	-1.0	0.4	-0.7	1.1
Bone: maximum force	3.6	6.3	7.8	2.7	1.9	-2.8	-2.6	2.4
Bone: maximum moment	3.6	6.3	7.7	2.7	1.9	-2.8	-2.6	2.4
Mean time between licks in bursts	0.5	1.1	2.1	-1.5	-0.8	1.2	1.0	-0.8
Mean num. licks in bursts	0.3	0.5	1.0	-0.9	-1.0	0.6	0.3	-0.2
Cd content in liver	0.3	0.4	0.8	-0.9	-0.3	0.8	0.4	-0.2
Co content in liver	3.0	3.4	4.7	-2.1	-1.6	2.2	1.7	-1.5
Cu content in liver	0.8	0.9	2.0	0.5	0.4	-0.7	-1.3	1.4
Fe content in liver	0.1	0.1	0.5	0.1	0.7	-0.4	0.1	-0.2
K content in liver	0.4	0.4	1.0	-0.7	-1.0	0.6	-0.1	0.4
Mg content in liver	0.8	0.8	1.6	-0.9	-1.3	1.2	0.3	-0.0
Mn content in liver	1.3	1.4	2.5	-0.7	-1.6	0.7	-1.1	1.6
Na content in liver	0.4	0.5	0.9	0.4	0.1	-0.7	-0.9	0.9
Rb content in liver	0.8	0.9	2.2	0.5	0.1	-0.4	-1.3	1.5
Se content in liver	0.0	0.0	0.0	-0.0	-0.0	0.1	0.0	-0.0
Sr content in liver	0.7	0.6	0.9	-1.0	-0.0	0.5	0.9	-0.9
Zn content in liver	5.1	5.7	7.3	-2.4	-1.6	2.5	2.7	-2.6
Bone: minimum diameter	0.6	1.1	2.0	0.8	0.4	-0.9	-1.3	1.4
Time in familiar zone, hab. session 1	4.5	4.3	5.3	-2.3	-2.3	2.3	1.9	-1.6
Time in novel zone, hab. session 1	4.6	4.6	5.4	2.1	1.8	-2.3	-2.3	2.2
Total zone transitions, hab. session 1	0.4	0.6	1.3	0.0	-1.0	0.2	-0.9	1.1
Total locomotion distance, hab. session 1	1.1	1.5	3.6	-0.7	-1.9	0.7	-0.9	1.4
Locomotion velocity, hab. session 1	1.0	1.4	3.9	-1.0	-2.0	1.0	-0.5	0.9
Time in familiar zone, hab. session 2	5.7	6.0	7.3	-2.7	-2.1	2.7	2.5	-2.2
Time in novel zone, hab. session 2	6.6	6.7	7.8	2.8	2.2	-2.8	-2.7	2.4
Total zone transitions, hab. session 2	2.0	2.6	5.0	1.3	0.4	-1.2	-2.2	2.2
Total locomotion distance, hab. session 2	0.4	0.5	1.0	-0.1	-1.0	0.1	-0.8	1.0
Locomotion velocity, hab. session 2	0.6	0.8	1.6	0.0	-1.1	0.1	-1.0	1.3
Novel to familiar place preference ratio	4.1	4.4	5.8	2.1	1.5	-2.1	-2.4	2.3
Novelty place preference	2.9	3.1	4.3	1.7	1.2	-1.7	-2.1	2.0
Time in novel zone, NPP test	3.4	3.6	4.6	1.9	1.5	-1.9	-2.2	2.0
Total zone transitions, NPP test	1.0	1.4	2.2	1.3	0.3	-1.0	-1.5	1.4
Total locomotion distance, NPP test	0.7	0.9	2.0	0.7	-0.2	-0.7	-1.3	1.4
Locomotion velocity, NPP test	0.4	0.6	1.4	0.4	-0.5	-0.3	-1.1	1.2
Intraocular pressure	0.9	1.3	2.8	-0.7	-0.4	1.0	1.5	-1.7
Delta distance traveled before/after self-admin	0.6	0.6	1.2	1.0	0.8	-1.1	-0.4	0.2
Delta ambulatory time before/after self-admin	0.8	1.0	1.6	1.2	0.7	-1.3	-0.9	0.8
Parametrial fat weight	0.5	1.1	1.8	1.2	0.8	-1.4	-0.9	0.8
Pavlov. Cond. lever latency	0.6	0.7	1.8	-0.3	0.4	0.0	1.2	-1.4
Pavlov. Cond. magazine entry latency	1.2	1.6	2.9	-1.4	-1.3	1.7	0.9	-0.7
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.4	0.6	-0.1	-0.4	0.4
Pavlov. Cond. index score	0.3	0.3	0.6	-0.5	-0.7	0.8	-0.2	0.4
Pavlov. Cond. latency score	0.3	0.4	0.7	-0.4	-0.8	0.7	-0.5	0.7
Pavlov. Cond. lever contacts	0.6	0.7	1.8	0.5	-0.1	-0.2	-1.2	1.4
Pavlov. Cond. magazine entry number	0.6	0.8	1.7	0.9	0.8	-1.3	-0.7	0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	-0.6	-0.1	0.5	1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.6	-0.8	0.9	-0.1	0.3
Pavlov. Cond. response bias	0.4	0.5	1.3	-0.7	-0.7	1.1	0.4	-0.3
Pavlov. Cond. lever latency	1.2	1.6	2.7	1.3	1.6	-1.4	-1.0	0.7
Pavlov. Cond. magazine entry latency	1.7	2.0	3.4	-1.4	-1.8	1.8	1.0	-0.7
Pavlov. Cond. change in total contacts	0.7	1.0	1.4	-1.2	-1.0	1.2	1.0	-0.8
Pavlov. Cond. index score	1.6	2.1	3.0	-1.6	-1.7	1.7	1.2	-0.9
Pavlov. Cond. latency score	1.6	2.1	3.5	-1.5	-1.9	1.7	1.1	-0.7
Pavlov. Cond. lever contacts	1.3	1.8	2.3	-1.4	-1.5	1.5	1.2	-1.0
Pavlov. Cond. magazine entry number	1.6	2.0	3.2	1.6	1.8	-1.8	-1.0	0.6
Pavlov. Cond. intertrial magazine entries	0.5	0.8	1.8	0.9	1.3	-1.1	-0.2	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	3.2	-1.7	-1.8	1.8	1.1	-0.8
Pavlov. Cond. response bias	2.1	2.9	4.0	-1.8	-1.8	2.0	1.6	-1.3
Time in closed arm before self-admin	0.5	0.7	1.4	0.6	-0.0	-0.6	-1.1	1.2
Time in closed arm after self-admin	0.2	0.2	0.7	0.0	0.8	-0.5	-0.0	-0.0
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	0.1	0.3	0.3	-0.3
Time in open arm after self-admin	1.2	1.4	2.3	1.5	1.3	-1.5	-0.6	0.3
Bone: periosteal estimation	1.6	3.4	5.2	1.5	1.0	-1.8	-2.2	2.3
Bone: periosteal perimeter	0.5	0.9	2.4	0.3	-0.3	-0.4	-1.3	1.5
Bone: post-yield work	0.5	0.7	1.0	1.0	0.9	-0.9	-0.7	0.5
Progressive ratio test 1 active lever presses	0.3	0.4	1.0	0.3	1.0	-1.0	-0.1	0.1
Progressive ratio test 1 breakpoint	0.3	0.4	1.0	0.3	1.0	-1.0	-0.1	0.0
Progressive ratio test 1 inactive lever presses	0.2	0.3	1.1	-1.0	-0.3	0.3	0.6	-0.4
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.6	0.1	-0.2	0.3	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	-0.7	-0.1	-0.1	0.3	-0.2
Progressive ratio test 2 inactive lever presses	0.3	0.4	1.1	0.0	0.6	-1.1	-0.5	0.6
Incentive Sensitization - Responses	0.3	0.4	0.6	-0.8	-0.5	0.6	0.6	-0.5
Incentive Sensitization - Breakpoint	0.3	0.4	0.7	-0.8	-0.7	0.6	0.5	-0.4
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.2	-0.4	-0.3	0.4	0.4	-0.4
Progressive ratio	0.5	0.8	1.8	0.8	1.3	-1.2	-0.2	-0.0
Food seeking constrained by brief footshock	1.5	1.8	3.0	-1.2	-1.7	1.7	1.0	-0.9
Seeking ratio, punishment vs. effort	1.6	2.3	4.0	-1.4	-2.0	2.0	1.0	-0.7
Retroperitoneal fat weight	1.2	4.9	10.2	2.5	3.2	-2.7	-0.6	-0.0
Reaction time number correct	0.4	0.7	1.7	0.9	1.3	-0.9	0.2	-0.5
Reaction time mean minus median	0.5	1.3	2.3	-1.2	-1.5	1.4	0.6	-0.4
Reaction time mean minus median AUC	0.4	1.1	3.3	-0.7	-1.8	0.9	-0.5	0.9
Reaction time num false alarms	0.4	0.6	1.0	1.0	1.0	-0.9	-0.4	0.2
Reaction time num false alarms AUC	0.3	0.5	1.1	0.9	1.1	-0.8	-0.2	-0.1
Reaction time trials correct on left	0.4	0.7	1.7	0.9	1.3	-0.9	0.2	-0.5
Reaction time trials on left	0.4	0.7	1.6	0.9	1.3	-0.9	0.1	-0.4
Reaction time mean	0.6	0.9	2.3	-0.8	-1.5	1.1	-0.1	0.5
Reaction time mean AUC	0.3	0.4	1.0	-0.4	-1.0	0.6	-0.4	0.6
Median of all reaction times	0.4	0.5	1.3	-0.5	-1.1	0.8	-0.3	0.6
Reaction time omissions	0.2	0.2	0.6	0.0	-0.2	-0.2	-0.7	0.8
Reaction time false alarm rate	0.2	0.2	0.4	0.6	0.3	-0.5	-0.5	0.5
Reaction time premature initiation rate	1.8	2.5	3.2	-1.7	-1.2	1.4	1.8	-1.7
Reaction time premature initiations	1.2	2.1	4.0	-1.3	-0.5	1.0	1.9	-2.0
Std. dev. reaction times	0.3	0.6	1.5	-0.7	-1.2	0.9	-0.0	0.3
Reaction time trials completed	0.4	0.7	1.6	0.9	1.3	-0.9	0.1	-0.4
Reaction time trials AUC	0.4	0.8	1.9	0.9	1.4	-1.0	0.2	-0.6
Run reversals in cocaine runway, females	1.5	1.5	4.0	-1.2	-2.0	1.3	0.3	0.1
Run reversals in cocaine runway, males	1.4	1.4	3.3	-1.4	-1.8	1.3	0.3	0.1
Latency to leave start box in cocaine runway	1.1	1.2	2.5	1.0	0.0	-0.7	-1.5	1.6
Latency to leave start box in cocaine runway, F	1.9	2.1	4.4	1.2	-0.1	-0.9	-2.0	2.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.1	0.3	-0.0	0.4	-0.5
Std. dev. time between licks in bursts	0.4	0.5	1.1	-0.8	-1.0	0.4	-0.4	0.7
Total sessions with >9 infusions	0.5	0.6	1.9	-0.1	0.9	-1.4	-0.4	0.5
Short access day 1 total inactive lever presses	0.7	0.9	1.3	-1.1	-0.4	0.9	1.1	-1.0
Short access day 10 total inactive lever presses	0.7	1.8	3.3	-1.2	-0.2	0.9	1.8	-1.8
Short access day 1 total infusions	0.4	0.5	1.4	-0.2	0.9	-1.2	-0.3	0.4
Short access day 10 total infusions	0.1	0.2	0.7	-0.1	0.5	-0.9	-0.0	0.1
Short access total infusions	0.8	1.1	3.0	0.2	1.1	-1.7	-0.7	0.7
Short access day 1 locomotion	0.7	0.9	2.4	-1.5	-0.3	0.5	1.1	-0.8
Short access day 10 total locomotion	2.6	4.8	8.2	-2.9	-0.9	1.8	2.6	-2.3
Short access total locomotion	0.8	0.9	2.2	-1.5	-0.2	0.3	1.1	-1.0
One hour access (0.3 mA shock)	0.2	0.2	0.7	-0.0	0.8	-0.4	0.2	-0.3
Compulsive drug intake	0.0	0.0	0.0	0.0	-0.2	0.1	-0.2	0.2
One hour access (shock baseline)	0.1	0.2	0.5	-0.7	0.2	0.0	0.6	-0.5
Social response proportion	0.6	0.6	2.0	-0.7	-1.4	0.8	0.1	0.1
Social responses	5.8	7.5	16.3	-3.0	-4.0	3.1	1.4	-0.7
Social time	0.6	0.8	1.5	1.1	1.2	-0.9	-0.4	0.1
Soleus weight	4.9	14.3	20.4	4.5	4.4	-4.4	-2.9	2.1
Bone: stiffness	4.2	6.8	9.0	2.8	2.4	-3.0	-2.6	2.3
Tibialis anterior weight	1.1	3.7	5.5	2.4	2.3	-2.1	-1.5	1.0
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.7	-1.1	-1.3	0.9	0.0	0.3
Time to tail flick, vehicle, after self-admin	1.0	1.4	2.3	-0.7	-0.6	1.2	1.4	-1.5
Time to tail flick, test, before self-admin	0.5	0.5	0.9	-0.5	-0.9	0.6	-0.5	0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.5	0.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.2	1.1	1.1	-0.4	0.4	-0.8
Delta time to tail flick, test, before/after SA	0.4	0.5	1.3	-0.2	0.3	0.1	0.9	-1.1
Tibia length	0.8	2.3	2.9	-1.6	-1.7	1.7	1.4	-1.2
Ambulatory time before self-admin	0.3	0.5	0.7	-0.8	-0.7	0.8	0.6	-0.4
Ambulatory time after self-admin	0.0	0.0	0.1	0.2	-0.1	-0.4	-0.2	0.1
Bone: tissue strength	5.0	5.0	7.0	2.4	2.3	-2.6	-2.0	1.7
Total heroin consumption	1.3	1.5	3.5	-1.3	-1.9	1.3	0.6	-0.3
Bone: trabecular number	0.4	0.6	1.4	0.1	-1.0	0.2	-0.9	1.2
Bone: trabecular spacing	1.4	1.9	4.5	-0.6	0.8	0.6	1.8	-2.1
Bone: trabecular thickness	3.8	4.8	10.9	1.4	-0.4	-1.5	-3.0	3.3
Bone: trabecular tissue density	3.0	4.4	8.7	2.3	2.9	-2.5	-1.0	0.5
Water consumed over 24 hours	1.0	1.3	1.7	1.2	0.7	-1.2	-1.3	1.3
Number of responses in last shaping day	2.9	3.2	6.8	-2.6	-0.9	1.5	1.9	-1.6