Sult4a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Sult4a1	0.02	0.02	1.5e-03	0.01	0.02	0	0.01	7.1e-03	1.5e-03	1.8e-01	1.3e-02
2	NAcc	gene expression	Sult4a1	0.07	0.05	1.7e-06	0.06	0.05	0.06	0.05	3.1e-07	9.7e-07	3.6e-07	1.0e-06
3	Brain	mRNA stability	Sult4a1	0.03	0.02	1.5e-04	0.05	0.03	0.03	0	2.8e-05	3.5e-04	7.0e-04	2.3e-01
4	IL	gene expression	Sult4a1	0.26	0.15	3.4e-03	0.07	0.06	0.05	0.08	1.1e-02	1.5e-02	2.8e-02	6.4e-03
5	OFC	mRNA stability	Sult4a1	0.39	0.19	9.7e-03	0.08	0.02	0.01	0.05	7.3e-03	9.9e-02	1.8e-01	2.9e-02
6	Brain	gene expression	Sult4a1	0.17	0.11	2.0e-03	-0	0.02	0.03	-0	9.3e-01	9.7e-03	1.3e-03	7.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.3	0.5	1.0	-0.8	0.9	0.6	-1.0	0.3	-0.1
Area under the delay curve	1.6	1.7	2.8	-1.7	1.5	1.6	-1.3	-0.0	-1.0
BMI with tail	1.4	4.5	7.0	2.5	-2.4	-2.7	2.6	-0.7	0.8
BMI without tail	1.2	2.4	6.0	1.5	-1.2	-1.4	1.6	-2.4	-0.1
Body weight	0.9	3.8	5.5	2.3	-2.2	-2.3	1.8	-1.6	1.2
Weight adjusted by age	0.5	0.5	2.0	0.6	-0.6	-0.5	0.6	-1.4	-0.1
Bone surface	0.1	0.1	0.4	-0.2	0.3	0.2	-0.6	0.2	0.4
Bone volume	0.1	0.1	0.4	-0.2	0.4	0.2	-0.6	0.1	0.2
Breakpoint value in progressive ratio session	0.2	0.2	0.5	0.3	-0.1	-0.1	0.7	-0.7	-0.6
Number of licking bursts	0.3	0.4	0.8	-0.5	0.5	0.9	-0.9	-0.3	0.5
Context. condit. distance diff. score	4.1	4.9	8.0	2.8	-2.7	-2.5	2.1	-0.7	1.8
Locomotion velocity, session 1	1.0	1.1	1.8	1.1	-1.1	-1.4	1.2	-1.0	-0.1
Locomotion distance, session 1	0.1	0.1	0.2	-0.3	0.0	0.1	-0.5	0.4	0.2
Locomotion velocity, session 2	2.9	3.4	8.5	1.6	-1.4	-1.8	2.0	-2.9	-0.5
Locomotion distance, session 2	0.4	0.5	1.2	-0.9	0.6	0.4	-0.1	0.7	-1.1
Locomotion velocity, session 3	1.7	2.0	3.7	1.4	-1.3	-1.5	1.5	-1.9	-0.1
Locomotion distance, session 3	0.3	0.4	0.8	-0.4	0.6	0.5	-0.4	-0.9	-0.5
Stereotopy head waving bouts, day 3	1.5	1.8	3.7	1.1	-1.1	-1.7	1.9	-1.1	-0.7
Stereotopy head waving duration, day 3	4.3	5.2	7.9	2.5	-2.5	-2.8	2.4	-2.0	1.0
Locomotion velocity, session 7	0.4	0.4	1.0	0.5	-0.4	-0.5	1.0	-0.9	-0.4
Locomotion distance, session 7	0.4	0.5	1.5	-0.7	0.8	0.6	0.0	0.4	-1.2
Stereotopy head waving bouts, day 7	5.2	5.8	7.9	2.7	-2.6	-2.8	2.5	-2.3	1.2
Stereotopy head waving duration, day 7	3.0	3.7	5.0	2.1	-2.0	-2.0	1.6	-2.2	1.3
Locomotion velocity, session 8	6.8	8.2	12.3	3.3	-3.3	-3.5	3.4	-1.6	0.8
Locomotion distance, session 8	1.4	2.1	3.3	1.7	-1.6	-1.7	1.8	-0.7	0.3
Degree of sensitization distance	0.7	0.7	1.6	0.7	-0.7	-0.9	1.2	0.9	-0.2
Degree of sensitization stereotypy	3.3	3.6	4.9	2.2	-2.1	-2.0	1.4	-1.9	1.7
Conditioned locomotion	0.2	0.3	0.7	-0.1	0.2	0.5	-0.7	0.3	0.8
Cocaine response after cond. corrected	0.1	0.1	0.4	0.2	-0.2	0.0	-0.2	-0.4	0.6
Cocaine response after cond. not corrected	0.3	0.3	0.8	0.3	-0.3	0.0	-0.3	-0.8	0.9
Cocaine response before conditioning	0.1	0.1	0.3	-0.3	0.3	0.4	-0.6	0.1	0.3
Saline control response	0.3	0.4	1.5	0.3	-0.3	-0.1	-0.3	-1.2	0.8
Bone: connectivity density	0.1	0.2	0.5	-0.5	0.5	0.5	-0.7	-0.1	0.0
Bone: cortical apparent density	1.4	1.8	2.3	-1.5	1.5	1.3	-0.6	1.4	-1.5
Bone: cortical area	0.9	1.4	3.3	1.3	-1.4	-1.1	0.4	-0.4	1.8
Bone: cortical porosity	0.3	0.4	0.9	0.6	-0.5	-0.6	-0.1	-0.5	1.0
Bone: cortical porosity	0.8	0.8	1.6	1.0	-0.9	-0.9	0.2	-0.9	1.3
Bone: cortical thickness	0.4	0.6	2.9	-0.4	0.3	0.4	-0.5	1.7	0.2
Bone: cortical thickness	0.3	0.4	1.3	0.3	-0.5	-0.3	0.0	1.1	0.8
Bone: cortical tissue density	1.3	1.7	2.5	-1.4	1.4	1.2	-0.4	1.4	-1.6
Condit. Reinf. active minus inactive responses	1.3	1.5	2.4	-1.6	1.2	1.5	-1.3	1.1	-0.3
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.8	-0.4	0.1	0.6	-1.0	0.9	1.4
Condit. Reinf. active responses	2.3	2.8	4.7	-2.2	1.9	2.1	-1.6	0.7	-1.1
Condit. Reinf. inactive responses	2.0	2.4	4.6	-1.8	1.8	1.6	-0.8	0.1	-2.2
Incentive salience index mean	1.9	2.3	3.8	-1.9	1.7	1.8	-1.4	1.1	-1.0
Condit. Reinf. lever presses	1.6	2.2	3.6	-1.8	1.7	1.6	-0.7	0.6	-1.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.8	-0.1	0.1	0.0	0.0	0.9	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.0	-0.0	-0.0	0.0	0.7	0.1
Condit. Reinf. active responses	0.3	0.4	0.8	0.7	-0.7	-0.9	0.9	0.2	-0.0
Condit. Reinf. inactive responses	0.6	0.8	1.4	1.0	-0.8	-1.2	1.2	-0.3	-0.1
Condit. Reinf. lever presses	0.3	0.5	1.9	-0.2	0.3	-0.2	0.8	-0.3	-1.4
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	0.2	-0.1	-0.4	0.5	0.5	-0.5
Conditioned reinforcement - actives	0.6	0.6	1.5	-0.8	0.6	0.6	-0.9	1.2	-0.1
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.1	0.0	0.2	0.1	-0.1	-0.2
Conditioned locomotion	0.9	1.0	1.5	1.1	-0.9	-1.1	1.2	-1.2	-0.3
Patch foraging indifference point 0 sec	0.1	0.1	0.3	-0.4	0.4	0.3	-0.5	0.2	0.1
Patch foraging indifference point AUC	0.5	0.6	2.0	-0.5	0.5	0.4	0.1	1.4	-0.9
Delay disc. indifference point, 0s delay	0.2	0.3	0.5	0.6	-0.5	-0.4	0.3	-0.7	0.5
Delay disc. indifference point, 16s delay	2.9	2.9	4.5	-2.1	2.1	1.9	-1.5	0.2	-1.6
Delay disc. indifference point, 2s delay	0.2	0.3	0.6	-0.8	0.5	0.7	-0.4	-0.2	-0.2
Delay disc. indifference point, 24s delay	0.6	0.5	1.0	-0.9	0.8	0.8	-0.3	0.0	-1.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	-0.4	0.3	0.3	-0.2	-0.6	-0.1
Delay disc. indifference point, 8s delay	2.3	2.4	3.7	-1.9	1.8	1.8	-1.6	0.6	-1.1
Indifference point function ln k	1.2	1.7	4.1	1.4	-1.1	-1.3	0.7	-2.0	0.7
Indifference point function log k	1.2	1.7	4.1	1.4	-1.1	-1.3	0.7	-2.0	0.7
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.5	0.5	0.5	-0.7	0.1	0.2
Patch foraging total patch changes 12 sec	0.3	0.3	1.9	0.2	-0.1	-0.1	0.3	1.4	0.1
Patch foraging total patch changes 18 sec	0.5	0.6	1.2	-0.7	0.7	0.6	-1.0	1.1	0.2
Patch foraging total patch changes 24 sec	0.2	0.2	0.6	-0.1	0.4	0.0	0.3	-0.8	-0.8
Patch foraging total patch changes 6 sec	0.3	0.5	2.5	-0.3	0.2	0.3	-0.4	1.6	0.6
Patch foraging time to switch 0 sec	0.3	0.5	1.2	-0.5	0.7	0.3	-0.2	-1.0	-1.1
Patch foraging water rate 0 sec	0.7	1.1	2.2	1.1	-1.3	-0.9	0.6	0.2	1.5
Patch foraging water rate 12 sec	1.1	1.8	4.7	1.2	-1.2	-1.1	0.8	-2.2	0.9
Patch foraging water rate 18 sec	0.1	0.1	0.5	0.0	-0.5	-0.1	-0.1	0.1	0.7
Patch foraging water rate 24 sec	1.3	1.8	2.6	1.4	-1.6	-1.6	1.4	-1.1	0.7
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.3	0.2	0.4	-0.5	-0.5	0.2
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.3	-1.5	1.5	1.2	-1.5	0.7	-0.5
Distance traveled before self-admin	0.2	0.2	1.0	-0.1	0.1	0.3	0.1	1.0	-0.2
Distance traveled after self-admin	0.4	0.5	1.0	0.6	-0.6	-0.7	1.0	-0.8	-0.3
Extensor digitorum longus weight	0.2	0.8	2.1	0.6	-0.4	-0.6	1.1	-1.5	-0.7
Bone: elastic displacement	1.6	1.8	3.4	1.4	-1.4	-1.4	1.2	-1.8	0.6
Bone: elastic work	4.6	6.0	8.0	2.8	-2.7	-2.8	2.5	-2.3	1.2
Bone: endosteal estimation	3.3	7.1	9.3	3.1	-2.9	-2.9	2.3	-3.0	1.6
Bone: endosteal perimeter	2.8	5.9	12.0	2.6	-2.4	-2.2	1.6	-3.5	1.7
Epididymis fat weight	0.4	1.0	1.5	1.2	-1.2	-1.2	1.0	-0.6	0.7
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	0.2	0.1	0.0	0.2	-0.1
Delta time in open arm before/after self-admin	1.0	1.0	2.7	1.0	-0.7	-0.9	0.9	-1.7	0.2
Diff in mean of infusions in LGA sessions	1.6	1.7	4.5	-1.3	1.0	1.2	-1.2	2.1	-0.2
Delay discount exponential model param	1.6	1.7	2.7	1.6	-1.5	-1.6	1.2	0.1	1.0
Extinction: sum of active levers before priming	0.4	0.4	0.9	-0.2	0.4	0.4	0.7	0.8	-0.9
Active lever presses in extinction session 6	0.4	0.4	0.9	0.7	-1.0	-0.3	0.8	0.2	0.5
Bone: final force	0.7	1.1	1.6	1.1	-1.3	-1.2	1.0	0.8	0.9
Bone: final moment	1.1	1.8	2.8	1.5	-1.7	-1.5	1.3	0.8	1.2
Food consumed during 24 hour testing period	1.9	2.3	3.8	1.8	-1.8	-1.9	1.4	0.4	1.3
Glucose	1.3	1.9	3.4	-1.4	1.2	1.4	-1.8	1.6	0.4
Heart weight	1.1	1.6	4.6	1.3	-1.4	-1.0	0.1	0.2	2.1
Delay discount hyperbolic model param	1.1	1.1	1.9	1.4	-1.2	-1.3	1.0	0.2	0.8
Intermittent access intake day 1-15 change	0.5	0.5	0.9	-0.9	0.7	0.7	-0.9	0.5	-0.4
Intermittent access intake escalation	0.3	0.3	0.7	-0.8	0.6	0.6	-0.8	-0.0	-0.3
Intermittent access intake escalation 2	0.3	0.3	1.0	-0.5	0.2	0.2	-1.0	0.5	0.6
Intermitt. access day 1 inactive lever presses	1.0	1.1	2.4	1.3	-1.1	-0.8	1.6	-0.7	0.1
Intermitt. access day 15 inactive lever presses	0.8	0.9	2.2	0.9	-1.0	-0.8	1.5	0.9	0.0
Intermitt. access escalation Index	0.2	0.1	0.4	-0.2	-0.2	-0.1	0.3	-0.7	-0.4
Intermittent access day 1 total infusions	0.3	0.4	0.6	0.8	-0.7	-0.8	0.4	0.2	0.5
Intermittent access day 15 total infusions	0.1	0.1	0.3	0.3	-0.4	-0.5	-0.1	0.0	0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.2	-0.5	-0.6	0.0	0.1	0.3
Intermittent access total infusions	0.3	0.4	0.7	0.6	-0.7	-0.8	0.1	-0.2	0.7
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.2	-0.1	-0.2	-0.0	-0.1	-0.0
Intermittent access day 15 total locomotion	0.4	0.5	0.9	0.7	-0.7	-0.8	0.5	-0.9	0.1
Intermittent access total locomotion	0.5	0.6	0.8	0.9	-0.8	-0.9	0.8	-0.8	0.0
Intermittent access standard deviation	0.5	0.5	1.0	0.8	-0.9	-1.0	0.7	-0.3	0.4
Left kidney weight	10.9	30.7	46.0	6.5	-6.2	-6.8	6.7	-3.3	1.8
Right kidney weight	12.2	34.1	51.8	6.9	-6.7	-7.2	6.8	-2.8	2.5
Cocaine induced anxiety	2.4	2.8	4.7	2.1	-1.9	-1.7	2.2	-0.7	0.7
Post-drug Anxiety	1.3	1.5	2.5	1.6	-1.4	-1.2	1.5	-0.4	0.7
Baseline Anxiety	2.4	2.6	3.9	-2.0	1.9	1.8	-1.8	0.7	-0.9
Tail length	0.1	0.3	1.1	-0.4	0.4	0.4	-0.6	-1.0	-0.2
Length with tail	0.0	0.2	0.6	0.3	-0.3	-0.4	-0.1	-0.8	0.3
Length without tail	0.2	0.4	0.8	0.5	-0.5	-0.8	0.6	0.9	0.0
Times rat made contact with spout	1.1	1.3	1.8	1.3	-1.4	-1.3	0.9	-0.1	1.2
Lifetime Intake	0.6	0.7	1.2	0.9	-1.0	-1.1	0.3	-0.4	0.9
Liver weight, left	0.1	0.2	0.6	0.3	-0.3	-0.5	0.8	-0.2	-0.3
Liver weight, right	0.1	0.2	0.7	0.3	-0.1	-0.2	0.3	-0.8	-0.0
Locomotor activity	1.6	2.6	4.0	1.9	-2.0	-1.8	1.3	-0.8	1.6
Locomotor testing distance	0.1	0.1	0.4	0.1	-0.3	-0.1	-0.2	0.2	0.6
Locomotor testing rearing	0.4	0.6	0.9	0.8	-0.9	-0.7	0.4	-0.7	1.0
Locomotion in novel chamber	0.7	0.9	4.4	-0.4	0.5	0.2	-0.7	-2.1	-0.3
Locomotion in novel chamber post-restriction	0.6	0.7	1.3	-0.9	1.1	1.0	-0.9	-0.4	-0.5
Fecal boli incidents, locomotor time 1	0.6	0.6	2.2	-0.1	0.3	0.1	0.8	-0.8	-1.5
Change in fecal boli incidents, locomotor task	0.4	0.4	1.3	0.6	-0.4	-0.0	-0.3	-0.4	1.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.0	0.3	-0.2	-0.4	0.5	-1.0	-0.3
Bouts of movement, locomotor time 1	0.2	0.2	0.6	-0.4	0.3	0.1	-0.0	0.8	-0.5
Total resting periods, locomotor time 1	0.3	0.3	0.6	-0.6	0.4	0.3	-0.2	0.7	-0.7
Rest time, locomotor task time 1	0.3	0.4	1.0	0.1	-0.3	-0.3	1.0	-0.2	-1.0
Distance moved, locomotor task time 1	0.2	0.2	0.5	0.2	-0.0	-0.1	-0.4	-0.7	0.7
Vertical activity count, locomotor time 1	0.3	0.3	0.8	-0.0	0.1	0.2	-0.8	-0.6	0.9
Time >=10cm from walls, locomotor time 2	0.5	0.6	1.6	-0.5	0.7	0.5	-0.2	-1.3	-0.9
Bouts of movement, locomotor time 2	0.8	0.9	2.9	-0.7	0.9	1.0	-0.4	1.7	-0.3
Total resting periods, locomotor time 2	1.1	1.1	4.4	-0.8	0.8	0.9	-0.4	2.1	-0.3
Rest time, locomotor task time 2	0.2	0.2	0.3	-0.6	0.3	0.4	-0.1	0.5	-0.5
Distance moved, locomotor task time 2	0.9	1.0	2.8	1.1	-0.7	-0.8	0.8	-1.7	0.5
Vertical activity count, locomotor time 2	0.8	0.8	2.3	1.1	-0.6	-0.6	0.8	-1.5	0.3
Light reinforcement 1	0.9	1.6	5.0	1.1	-0.6	-1.2	1.2	-2.2	-0.6
Light reinforcement 2	1.4	1.9	6.0	1.1	-0.6	-1.1	1.5	-2.4	-0.8
Bone: marrow area	3.4	7.4	9.9	3.1	-3.0	-2.9	2.4	-2.9	1.7
Bone: maximum diameter	4.7	8.6	12.3	3.5	-3.4	-3.2	2.4	-2.4	2.4
Bone: maximum force	1.9	3.2	4.9	2.1	-2.2	-2.0	1.5	0.2	1.9
Bone: maximum moment	2.5	4.3	6.7	2.4	-2.6	-2.4	1.8	0.3	2.1
Mean time between licks in bursts	1.3	1.8	4.7	-1.3	1.1	1.5	-2.2	0.6	1.0
Mean num. licks in bursts	1.7	2.0	4.0	1.6	-1.6	-2.0	1.7	-0.1	0.5
Cd content in liver	2.2	2.4	10.4	1.0	-1.5	-0.5	-0.6	-0.3	3.2
Co content in liver	0.7	0.8	1.7	1.0	-1.0	-1.3	0.8	0.2	0.5
Cu content in liver	4.8	5.8	8.9	-2.8	3.0	2.8	-2.6	-0.7	-1.7
Fe content in liver	0.4	0.4	0.9	0.5	-0.6	-0.6	0.0	-0.9	0.9
K content in liver	0.9	0.9	3.9	-0.6	0.7	-0.1	0.6	-0.3	-2.0
Mg content in liver	1.0	1.0	3.9	-0.9	1.0	0.4	0.2	-0.2	-2.0
Mn content in liver	0.5	0.6	1.1	0.4	-0.1	-0.6	1.0	-0.9	-1.1
Na content in liver	2.3	2.5	4.5	-1.7	1.3	1.8	-2.1	1.5	0.3
Rb content in liver	0.1	0.2	0.5	-0.3	0.1	0.2	-0.7	0.2	0.6
Se content in liver	0.9	1.1	2.6	-1.2	1.3	0.8	-0.4	-0.6	-1.6
Sr content in liver	0.5	0.4	0.7	-0.8	0.7	0.7	-0.8	0.5	-0.3
Zn content in liver	0.7	0.8	1.4	-1.1	1.1	0.9	-1.2	0.0	-0.4
Bone: minimum diameter	0.9	1.6	4.4	1.3	-1.1	-1.1	0.5	-2.1	0.9
Time in familiar zone, hab. session 1	0.6	0.6	0.9	0.7	-0.7	-0.8	1.0	-0.9	-0.1
Time in novel zone, hab. session 1	1.0	1.0	4.3	0.5	-0.6	-0.1	-0.8	0.4	2.1
Total zone transitions, hab. session 1	1.6	2.2	3.1	-1.8	1.7	1.7	-1.5	1.3	-0.9
Total locomotion distance, hab. session 1	0.5	0.7	2.6	-0.5	0.8	0.2	0.3	-0.9	-1.6
Locomotion velocity, hab. session 1	0.8	1.1	4.4	-0.6	0.9	0.3	0.5	-0.9	-2.1
Time in familiar zone, hab. session 2	0.4	0.4	1.2	-0.3	0.5	0.3	0.1	-1.1	-0.8
Time in novel zone, hab. session 2	1.1	1.1	3.8	0.7	-1.0	-0.6	-0.5	1.0	2.0
Total zone transitions, hab. session 2	0.2	0.3	1.0	0.0	-0.1	-0.5	0.8	0.3	-1.0
Total locomotion distance, hab. session 2	0.3	0.4	1.7	-0.1	0.3	-0.3	0.7	-0.5	-1.3
Locomotion velocity, hab. session 2	0.5	0.6	2.8	-0.4	0.6	-0.0	0.6	-0.3	-1.7
Novel to familiar place preference ratio	1.8	1.8	5.0	1.4	-1.5	-1.2	0.0	-0.4	2.2
Novelty place preference	2.4	2.4	5.8	1.7	-1.8	-1.5	0.2	-0.7	2.4
Time in novel zone, NPP test	3.4	3.5	9.0	2.0	-2.1	-1.7	0.2	-0.8	3.0
Total zone transitions, NPP test	0.2	0.3	0.6	-0.6	0.4	0.3	-0.0	0.8	-0.7
Total locomotion distance, NPP test	0.4	0.6	1.9	-0.1	0.2	-0.3	0.7	-1.0	-1.4
Locomotion velocity, NPP test	0.9	1.2	4.9	-0.7	0.9	0.4	0.5	-0.8	-2.2
Intraocular pressure	0.3	0.5	1.3	0.8	-0.7	-0.4	0.0	-0.3	1.2
Delta distance traveled before/after self-admin	2.1	2.3	5.1	1.5	-1.5	-1.5	1.3	-2.2	0.7
Delta ambulatory time before/after self-admin	2.3	2.5	5.4	1.6	-1.6	-1.4	1.1	-2.3	1.2
Parametrial fat weight	0.2	0.4	1.7	-0.6	0.5	0.2	0.2	0.2	-1.3
Pavlov. Cond. lever latency	2.2	2.8	4.3	2.0	-2.1	-1.8	1.4	-0.3	1.7
Pavlov. Cond. magazine entry latency	2.9	3.8	4.9	-2.2	2.0	2.1	-2.2	2.1	-0.5
Pavlov. Cond. change in total contacts	3.1	3.3	4.5	-2.1	2.0	2.0	-2.1	1.6	-0.6
Pavlov. Cond. index score	2.2	2.8	3.8	-2.0	1.8	1.8	-1.7	1.7	-0.8
Pavlov. Cond. latency score	1.5	2.0	2.9	-1.7	1.6	1.5	-1.5	1.1	-0.8
Pavlov. Cond. lever contacts	2.7	3.1	4.8	-2.2	2.2	1.9	-1.5	0.6	-1.8
Pavlov. Cond. magazine entry number	3.1	3.8	4.8	2.2	-2.0	-2.2	2.2	-2.1	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	-0.6	0.4	0.3	-0.4	0.0	-0.4
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.4	4.7	-2.2	2.0	2.1	-1.9	1.7	-0.9
Pavlov. Cond. response bias	3.8	4.7	6.5	-2.6	2.4	2.4	-2.2	1.8	-1.1
Pavlov. Cond. lever latency	0.4	0.5	2.2	0.5	-0.6	-0.0	-0.4	0.3	1.5
Pavlov. Cond. magazine entry latency	2.2	2.6	5.6	-1.8	1.9	1.4	-0.6	0.7	-2.4
Pavlov. Cond. change in total contacts	0.3	0.5	1.8	-0.5	0.4	-0.2	0.4	0.6	-1.3
Pavlov. Cond. index score	1.1	1.4	4.3	-1.3	1.3	0.8	-0.2	0.3	-2.1
Pavlov. Cond. latency score	1.3	1.7	5.2	-1.4	1.4	0.9	-0.2	0.3	-2.3
Pavlov. Cond. lever contacts	0.4	0.6	2.6	-0.4	0.5	-0.0	0.6	-0.1	-1.6
Pavlov. Cond. magazine entry number	1.6	2.0	6.6	1.4	-1.6	-0.9	0.0	-0.3	2.6
Pavlov. Cond. intertrial magazine entries	1.4	1.8	3.2	1.6	-1.6	-1.3	0.8	0.6	1.8
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	5.3	-1.4	1.4	0.8	-0.1	0.1	-2.3
Pavlov. Cond. response bias	0.6	0.8	3.2	-0.8	0.9	0.4	0.3	0.4	-1.8
Time in closed arm before self-admin	1.3	1.5	2.9	-1.7	1.1	1.3	-1.5	0.9	-0.6
Time in closed arm after self-admin	0.3	0.3	0.8	-0.5	0.2	0.5	-0.9	-0.2	0.3
Time in open arm before self-admin	0.3	0.3	0.7	-0.2	0.5	0.8	-0.4	-0.7	-0.0
Time in open arm after self-admin	0.9	1.0	3.2	0.9	-0.3	-0.6	1.2	-1.8	-0.6
Bone: periosteal estimation	2.7	5.6	7.7	2.8	-2.7	-2.5	1.8	-2.2	2.1
Bone: periosteal perimeter	2.9	4.9	6.5	2.6	-2.4	-2.0	1.3	-2.5	2.3
Bone: post-yield work	1.2	1.7	4.5	0.7	-1.1	-0.5	0.0	2.1	1.9
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	0.2	0.1	-0.4	0.2	-0.0
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	-0.5	0.4	0.3	-0.6	0.4	-0.2
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	0.3	-0.2	-0.2	0.7	-0.3	-0.4
Progressive ratio test 2 active lever presses	0.4	0.5	0.8	0.4	-0.8	-0.9	0.8	0.7	-0.0
Progressive ratio test 2 breakpoint	0.5	0.5	0.9	0.4	-0.8	-0.9	0.8	1.0	-0.1
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.4	0.2	-0.5	-0.5	0.7	0.5	-0.3
Incentive Sensitization - Responses	1.6	1.6	3.4	1.2	-1.5	-1.6	1.9	0.2	-0.1
Incentive Sensitization - Breakpoint	1.9	1.9	4.1	1.3	-1.7	-1.7	2.0	0.2	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.5	0.4	-0.2	-0.1	0.7	-0.1	-0.4
Progressive ratio	0.3	0.3	0.8	-0.5	0.1	0.7	-0.6	0.9	0.3
Food seeking constrained by brief footshock	0.4	0.5	1.0	0.7	-0.8	-1.0	0.9	0.0	0.1
Seeking ratio, punishment vs. effort	0.4	0.5	1.1	0.7	-0.5	-1.1	1.0	-0.2	-0.3
Retroperitoneal fat weight	0.6	2.1	4.0	1.4	-1.2	-1.8	2.0	-1.4	-0.5
Reaction time number correct	0.8	1.1	1.8	-1.3	1.3	1.3	-0.9	0.1	-0.7
Reaction time mean minus median	0.3	0.4	1.0	0.4	-0.6	-0.2	-0.1	0.8	1.0
Reaction time mean minus median AUC	0.6	0.7	1.3	1.0	-1.1	-0.7	0.6	0.1	1.1
Reaction time num false alarms	0.6	0.8	3.2	-0.1	-0.2	0.3	-1.2	0.3	1.8
Reaction time num false alarms AUC	0.4	0.6	2.2	0.0	-0.2	0.2	-0.9	0.6	1.5
Reaction time trials correct on left	0.8	1.1	1.8	-1.3	1.3	1.3	-0.9	0.1	-0.7
Reaction time trials on left	0.8	1.2	1.9	-1.4	1.3	1.4	-0.9	0.2	-0.7
Reaction time mean	0.3	0.4	1.2	-0.5	0.2	0.6	-0.8	1.1	0.4
Reaction time mean AUC	0.3	0.4	1.1	-0.5	0.3	0.6	-0.8	1.1	0.4
Median of all reaction times	0.5	0.7	1.6	-0.8	0.5	0.8	-1.0	1.3	0.2
Reaction time omissions	0.7	0.9	2.4	-0.7	0.5	1.0	-1.0	1.5	0.6
Reaction time false alarm rate	0.5	0.7	2.8	0.6	-0.8	-0.4	-0.4	0.4	1.7
Reaction time premature initiation rate	0.5	0.7	1.4	0.1	-0.3	-0.5	1.2	1.1	-1.0
Reaction time premature initiations	0.4	0.5	1.3	-0.5	0.3	0.1	0.7	1.1	-1.1
Std. dev. reaction times	0.2	0.2	0.6	0.2	-0.5	-0.0	-0.1	0.8	0.7
Reaction time trials completed	0.8	1.2	1.9	-1.4	1.3	1.4	-0.9	0.2	-0.7
Reaction time trials AUC	0.6	0.9	1.4	-1.2	1.2	1.2	-0.7	0.0	-0.7
Run reversals in cocaine runway, females	2.4	2.3	3.5	-1.6	1.9	1.6	-1.6	-0.8	-1.5
Run reversals in cocaine runway, males	0.9	0.8	2.2	1.1	-1.1	-0.5	0.3	-0.3	1.5
Latency to leave start box in cocaine runway	0.8	0.9	1.8	1.1	-0.9	-1.0	1.4	-0.8	-0.3
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	0.4	-0.2	-0.2	0.7	0.7	-0.5
Latency to leave start box in cocaine runway, M	1.6	1.6	2.6	1.3	-1.3	-1.3	1.3	-1.6	0.3
Std. dev. time between licks in bursts	0.6	0.7	1.1	-1.0	1.0	1.0	-0.7	0.3	-0.8
Total sessions with >9 infusions	0.2	0.3	0.5	0.5	-0.3	-0.4	-0.3	-0.7	0.7
Short access day 1 total inactive lever presses	2.3	2.6	3.9	1.9	-2.0	-1.9	1.8	-0.8	0.8
Short access day 10 total inactive lever presses	3.4	3.7	4.8	2.1	-2.2	-1.9	2.1	-2.0	0.8
Short access day 1 total infusions	1.1	1.2	1.9	1.1	-1.4	-1.3	0.6	-0.7	1.1
Short access day 10 total infusions	0.1	0.1	0.5	-0.3	0.3	0.3	-0.7	-0.1	0.2
Short access total infusions	0.7	0.8	1.2	1.0	-1.1	-1.1	0.4	-0.7	1.0
Short access day 1 locomotion	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.1	-0.3	-0.1
Short access day 10 total locomotion	0.6	0.6	1.1	-0.8	0.9	0.9	-1.0	0.5	-0.2
Short access total locomotion	0.0	0.0	0.2	-0.1	0.1	0.2	-0.4	0.0	0.1
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.0	-0.1	-0.3	-0.1	-0.3	-0.0
Compulsive drug intake	0.1	0.1	0.2	-0.3	0.2	0.2	0.1	0.4	-0.4
One hour access (shock baseline)	0.1	0.1	0.5	-0.1	-0.0	-0.1	-0.4	-0.7	0.2
Social response proportion	0.2	0.2	0.4	0.4	-0.2	-0.6	0.5	-0.5	-0.3
Social responses	0.4	0.6	2.4	-0.4	0.6	0.1	0.4	-0.5	-1.5
Social time	2.6	3.5	4.9	-2.2	2.1	2.1	-1.8	1.6	-1.1
Soleus weight	0.2	0.6	1.1	0.6	-0.7	-0.7	0.7	1.1	0.4
Bone: stiffness	1.2	1.9	6.4	0.9	-1.2	-0.6	-0.3	1.6	2.5
Tibialis anterior weight	0.2	0.6	2.5	-0.7	0.7	0.4	0.2	-0.1	-1.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.7	0.2	-0.3	-0.3	0.3	0.8	-0.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.5	-0.3	0.3	0.7	-0.5	-0.3	-0.0
Time to tail flick, test, before self-admin	0.1	0.1	0.5	0.2	0.1	-0.4	-0.0	-0.7	0.2
Time to tail flick, test, after self-admin	1.4	1.4	2.0	-1.4	1.4	1.4	-1.4	0.4	-0.6
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.4	-0.4	-0.4	0.3	-0.2	0.3
Delta time to tail flick, test, before/after SA	1.2	1.0	1.7	-1.3	1.1	1.2	-1.0	0.6	-0.8
Tibia length	0.6	1.6	2.7	1.3	-1.5	-1.4	0.8	-0.2	1.6
Ambulatory time before self-admin	0.2	0.2	0.9	0.1	0.1	0.1	0.4	1.0	-0.3
Ambulatory time after self-admin	0.2	0.3	0.6	0.5	-0.5	-0.4	0.5	-0.8	0.1
Bone: tissue strength	0.4	0.4	0.6	0.6	-0.8	-0.6	0.5	-0.0	0.7
Total heroin consumption	0.3	0.4	0.6	0.8	-0.8	-0.5	0.8	0.3	0.5
Bone: trabecular number	0.4	0.6	1.8	-0.4	0.5	0.6	-1.4	0.0	1.0
Bone: trabecular spacing	1.1	1.4	4.0	1.1	-0.9	-1.2	2.0	-0.7	-0.9
Bone: trabecular thickness	0.4	0.5	1.0	-0.8	0.9	0.5	-0.5	0.1	-1.0
Bone: trabecular tissue density	0.5	0.7	1.5	-1.0	0.7	0.6	-0.6	1.2	-0.6
Water consumed over 24 hours	3.3	4.0	6.0	2.3	-2.4	-2.3	1.4	-0.2	2.3
Number of responses in last shaping day	0.9	1.0	1.3	-1.1	1.1	0.9	-1.0	1.1	-0.6