Sult2a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Sult2a6	0.07	0.05	2.5e-06	0.04	0.05	0.05	0.04	6.0e-05	2.9e-06	2.6e-06	1.1e-05
2	Liver	intron excision ratio	chr1_84046905_84048446	0.1	0.07	2.3e-08	0.07	0.07	0.06	0.07	5.9e-08	3.5e-08	1.4e-07	5.0e-08
3	Liver	intron excision ratio	chr1_84048623_84059698	0.19	0.11	2.8e-16	0.14	0.14	0.15	0.14	6.4e-15	2.1e-15	8.9e-17	2.4e-15
4	Liver	intron excision ratio	chr1_84059792_84082110	0.04	0.03	6.1e-04	0	0.04	0.07	0	1.2e-01	3.8e-05	8.0e-08	9.4e-02
5	Liver	mRNA stability	Sult2a6	0.16	0.1	1.1e-13	0.12	0.12	0.12	0.12	1.1e-12	1.3e-13	1.1e-12	8.8e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.7	0.8	-0.8	-0.8	0.9	-0.9	-0.8
Area under the delay curve	0.7	0.8	1.2	1.1	0.9	-0.8	0.9	0.8
BMI with tail	0.6	2.2	3.2	0.7	1.4	-1.8	1.5	1.7
BMI without tail	0.2	0.5	0.9	-0.3	0.6	-0.9	0.7	1.0
Body weight	0.4	1.9	5.3	-2.3	-1.3	0.7	-1.1	-0.8
Weight adjusted by age	1.0	1.5	2.2	-1.5	-1.2	1.2	-1.2	-1.1
Bone surface	4.0	7.2	7.9	-2.8	-2.7	2.6	-2.7	-2.6
Bone volume	3.3	5.9	6.2	-2.5	-2.4	2.4	-2.4	-2.4
Breakpoint value in progressive ratio session	3.4	4.0	5.1	2.2	2.1	-1.9	2.0	1.9
Number of licking bursts	0.1	0.1	0.2	-0.2	0.3	-0.4	0.3	0.5
Context. condit. distance diff. score	0.1	0.1	0.2	-0.5	-0.4	0.3	-0.3	-0.3
Locomotion velocity, session 1	0.7	0.7	1.0	-0.5	-0.9	0.9	-0.9	-1.0
Locomotion distance, session 1	3.5	4.5	4.6	-2.0	-2.1	2.1	-2.1	-2.1
Locomotion velocity, session 2	0.3	0.4	0.6	-0.8	-0.7	0.5	-0.6	-0.5
Locomotion distance, session 2	2.6	3.6	5.1	-2.3	-1.9	1.8	-1.8	-1.7
Locomotion velocity, session 3	0.0	0.1	0.1	-0.3	-0.2	0.2	-0.2	-0.2
Locomotion distance, session 3	2.2	2.4	2.6	-1.4	-1.6	1.6	-1.5	-1.6
Stereotopy head waving bouts, day 3	0.9	1.1	1.2	1.0	1.0	-1.1	1.0	1.1
Stereotopy head waving duration, day 3	1.1	1.3	1.3	1.1	1.1	-1.1	1.1	1.1
Locomotion velocity, session 7	0.2	0.2	0.4	-0.2	-0.4	0.6	-0.5	-0.6
Locomotion distance, session 7	0.1	0.2	0.2	-0.4	-0.4	0.5	-0.4	-0.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	-0.5	-0.5	0.4	-0.4	-0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.1	-0.3	-0.4	0.2	-0.3	-0.3
Locomotion velocity, session 8	0.1	0.2	0.2	-0.3	-0.4	0.5	-0.4	-0.4
Locomotion distance, session 8	1.0	1.4	2.1	-1.4	-1.2	1.1	-1.1	-1.1
Degree of sensitization distance	0.6	0.6	0.6	0.7	0.8	-0.8	0.7	0.8
Degree of sensitization stereotypy	0.7	0.8	1.1	-1.1	-0.9	0.8	-0.8	-0.8
Conditioned locomotion	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.1	-0.0
Cocaine response after cond. corrected	1.7	2.1	2.3	1.3	1.5	-1.5	1.5	1.5
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.3	0.0	-0.1	0.1	0.1
Cocaine response before conditioning	7.4	8.9	10.7	-3.3	-3.1	2.8	-2.9	-2.8
Saline control response	1.7	2.2	2.9	-1.7	-1.5	1.4	-1.5	-1.3
Bone: connectivity density	0.2	0.3	0.3	-0.6	-0.5	0.6	-0.6	-0.5
Bone: cortical apparent density	0.3	0.5	0.6	0.8	0.7	-0.6	0.7	0.6
Bone: cortical area	1.4	2.1	3.1	-1.8	-1.5	1.3	-1.4	-1.3
Bone: cortical porosity	0.4	0.4	0.5	0.5	0.7	-0.7	0.6	0.7
Bone: cortical porosity	0.2	0.2	0.3	0.2	0.5	-0.5	0.5	0.6
Bone: cortical thickness	0.2	0.3	0.4	0.4	0.6	-0.6	0.6	0.6
Bone: cortical thickness	0.1	0.2	0.3	-0.6	-0.4	0.3	-0.3	-0.3
Bone: cortical tissue density	0.4	0.5	0.7	0.8	0.7	-0.6	0.7	0.6
Condit. Reinf. active minus inactive responses	0.4	0.4	0.6	0.3	0.7	-0.8	0.7	0.8
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.8	0.8	1.2	-1.3	1.2	1.3
Condit. Reinf. active responses	0.0	0.0	0.2	-0.4	-0.2	0.1	-0.1	-0.1
Condit. Reinf. inactive responses	2.2	2.7	2.9	-1.4	-1.7	1.7	-1.7	-1.7
Incentive salience index mean	0.0	0.0	0.2	-0.4	-0.1	-0.1	0.0	0.1
Condit. Reinf. lever presses	0.3	0.5	0.8	-0.9	-0.7	0.6	-0.6	-0.6
Condit. Reinf. active minus inactive responses	4.1	5.3	5.5	-2.2	-2.3	2.3	-2.4	-2.3
Condit. Reinf. active-inactive response ratio	3.7	4.3	4.3	-2.0	-2.1	2.1	-2.1	-2.0
Condit. Reinf. active responses	4.2	5.9	6.2	-2.3	-2.5	2.5	-2.5	-2.4
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.3	-0.5	0.5	-0.6	-0.6
Condit. Reinf. lever presses	0.3	0.5	0.7	-0.8	-0.7	0.6	-0.7	-0.6
Condit. Reinf. lever reinforcers received	5.6	7.8	8.2	-2.6	-2.8	2.8	-2.9	-2.8
Conditioned reinforcement - actives	0.3	0.5	0.9	0.2	0.7	-0.8	0.7	0.9
Conditioned reinforcement - inactives	0.4	0.6	1.1	-1.1	-0.8	0.6	-0.8	-0.7
Conditioned locomotion	0.6	0.7	1.1	0.7	0.9	-0.7	0.9	1.0
Patch foraging indifference point 0 sec	0.2	0.3	0.3	0.6	0.6	-0.5	0.6	0.6
Patch foraging indifference point AUC	0.3	0.5	0.8	-0.1	0.6	-0.9	0.6	0.9
Delay disc. indifference point, 0s delay	1.3	1.4	1.7	-0.9	-1.2	1.2	-1.2	-1.3
Delay disc. indifference point, 16s delay	3.3	3.6	4.0	2.0	1.9	-1.9	1.9	1.8
Delay disc. indifference point, 2s delay	0.3	0.3	0.7	0.8	0.6	-0.4	0.5	0.5
Delay disc. indifference point, 24s delay	1.7	1.9	2.0	1.2	1.4	-1.4	1.4	1.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.4	-0.4
Delay disc. indifference point, 8s delay	0.9	1.0	1.7	1.3	1.0	-0.9	1.0	0.8
Indifference point function ln k	3.5	6.0	7.7	-1.7	-2.4	2.8	-2.5	-2.7
Indifference point function log k	3.5	6.0	7.7	-1.7	-2.4	2.8	-2.5	-2.7
Patch foraging total patch changes 0 sec	0.2	0.5	0.5	0.6	0.7	-0.7	0.7	0.7
Patch foraging total patch changes 12 sec	0.3	0.3	0.5	0.1	0.5	-0.7	0.6	0.7
Patch foraging total patch changes 18 sec	0.1	0.2	0.3	-0.1	0.4	-0.5	0.5	0.6
Patch foraging total patch changes 24 sec	0.1	0.1	0.4	-0.7	-0.1	0.0	-0.1	0.1
Patch foraging total patch changes 6 sec	1.2	1.8	2.3	1.0	1.4	-1.5	1.4	1.5
Patch foraging time to switch 0 sec	4.4	9.0	11.6	3.4	3.0	-2.8	2.9	2.8
Patch foraging water rate 0 sec	1.5	3.1	4.9	-2.2	-1.7	1.6	-1.7	-1.5
Patch foraging water rate 12 sec	1.9	3.9	4.1	-1.9	-2.0	2.0	-2.0	-2.0
Patch foraging water rate 18 sec	0.4	0.7	0.8	-0.7	-0.8	0.9	-0.8	-0.8
Patch foraging water rate 24 sec	1.2	1.7	1.9	-1.2	-1.3	1.3	-1.3	-1.4
Patch foraging water rate 6 sec	6.9	10.1	13.1	-3.6	-3.2	2.9	-3.1	-2.9
Seeking ratio, delayed vs. immediate footshock	1.0	1.3	1.7	-0.6	-1.1	1.3	-1.2	-1.3
Distance traveled before self-admin	3.0	3.9	4.4	-2.0	-2.0	2.1	-1.9	-1.9
Distance traveled after self-admin	0.4	0.5	0.8	-0.4	-0.8	0.7	-0.8	-0.9
Extensor digitorum longus weight	0.2	0.9	2.8	-1.7	-0.9	0.4	-0.7	-0.5
Bone: elastic displacement	1.2	1.4	2.5	1.6	1.2	-1.0	1.0	1.0
Bone: elastic work	0.1	0.2	0.2	-0.3	-0.4	0.4	-0.4	-0.4
Bone: endosteal estimation	3.7	8.2	8.5	-2.8	-2.9	2.9	-2.8	-2.8
Bone: endosteal perimeter	2.2	4.6	4.9	-2.1	-2.2	2.2	-2.1	-2.1
Epididymis fat weight	0.2	0.8	1.3	1.1	0.8	-0.9	0.8	0.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.3	-0.4	0.5	-0.4	-0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.5	-0.4	0.2	-0.3	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.2	0.5	0.7	0.3	-0.2	0.3	0.2
Delay discount exponential model param	0.6	0.7	1.0	-1.0	-0.8	0.8	-0.8	-0.8
Extinction: sum of active levers before priming	0.2	0.2	0.3	-0.4	-0.5	0.4	-0.5	-0.5
Active lever presses in extinction session 6	0.7	0.7	1.0	0.3	0.8	-1.0	0.9	1.0
Bone: final force	2.9	4.6	6.2	-2.5	-2.2	2.0	-2.0	-2.0
Bone: final moment	4.0	6.4	8.4	-2.9	-2.5	2.4	-2.4	-2.3
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.5	-0.2	0.4	-0.3	-0.5
Glucose	1.5	2.3	4.3	2.1	1.5	-1.3	1.3	1.3
Heart weight	0.0	0.0	0.0	-0.2	0.1	-0.1	0.1	0.2
Delay discount hyperbolic model param	0.7	0.8	1.0	-1.0	-0.9	0.8	-0.9	-0.8
Intermittent access intake day 1-15 change	0.0	0.0	0.0	-0.2	0.0	-0.0	0.0	0.1
Intermittent access intake escalation	0.0	0.0	0.1	-0.4	-0.0	0.1	-0.1	0.1
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.2	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.3	0.2	0.5	-0.2	0.4	0.6
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.7	-0.8	-0.5	0.6	-0.5	-0.4
Intermitt. access escalation Index	1.0	1.4	1.6	1.0	1.2	-1.3	1.2	1.2
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.2	0.1	-0.1	0.0	0.2
Intermittent access day 15 total infusions	0.6	0.9	1.3	0.7	1.0	-0.9	0.9	1.1
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	0.4	0.6	-0.5	0.5	0.7
Intermittent access total infusions	0.1	0.1	0.2	-0.0	0.3	-0.3	0.3	0.4
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.2	0.1	-0.1	0.0	0.0
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.3	0.2	0.1	0.1	0.2
Intermittent access total locomotion	0.2	0.2	0.3	-0.3	-0.4	0.5	-0.5	-0.4
Intermittent access standard deviation	1.0	2.0	2.2	1.4	1.5	-1.4	1.4	1.4
Left kidney weight	3.7	17.2	29.7	-5.4	-4.1	3.6	-3.9	-3.4
Right kidney weight	2.8	12.8	23.1	-4.8	-3.6	3.0	-3.3	-2.9
Cocaine induced anxiety	0.4	0.6	0.9	-0.5	-0.9	0.7	-0.7	-0.9
Post-drug Anxiety	0.2	0.2	0.4	-0.3	-0.5	0.4	-0.5	-0.6
Baseline Anxiety	0.2	0.2	0.5	0.7	0.5	-0.4	0.3	0.3
Tail length	1.6	6.4	9.8	-3.1	-2.5	2.3	-2.4	-2.1
Length with tail	1.7	7.5	10.2	-3.2	-2.8	2.5	-2.6	-2.5
Length without tail	0.7	2.1	3.2	-1.8	-1.5	1.3	-1.4	-1.3
Times rat made contact with spout	0.1	0.1	0.3	0.5	0.2	-0.1	0.2	0.1
Lifetime Intake	0.1	0.1	0.2	-0.1	0.2	-0.3	0.2	0.4
Liver weight, left	0.8	1.4	4.0	-2.0	-1.2	0.6	-0.9	-0.7
Liver weight, right	0.1	0.1	0.3	-0.5	0.0	-0.4	0.2	0.3
Locomotor activity	0.2	0.3	0.6	-0.0	0.4	-0.8	0.6	0.7
Locomotor testing distance	0.0	0.1	0.1	-0.2	0.1	-0.4	0.3	0.3
Locomotor testing rearing	0.6	1.2	3.1	-1.8	-1.1	0.6	-0.8	-0.6
Locomotion in novel chamber	0.5	0.6	1.9	1.4	0.7	-0.3	0.6	0.4
Locomotion in novel chamber post-restriction	0.2	0.3	0.7	0.8	0.6	-0.2	0.5	0.4
Fecal boli incidents, locomotor time 1	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.4	-0.4
Change in fecal boli incidents, locomotor task	2.2	2.2	3.0	1.7	1.5	-1.3	1.4	1.3
Time >=10cm from walls, locomotor time 1	0.6	0.6	0.7	0.8	0.8	-0.8	0.8	0.8
Bouts of movement, locomotor time 1	0.6	0.7	1.0	-0.5	-0.8	0.9	-1.0	-1.0
Total resting periods, locomotor time 1	0.1	0.2	0.3	0.1	-0.3	0.4	-0.4	-0.5
Rest time, locomotor task time 1	1.1	1.4	1.6	-1.0	-1.2	1.2	-1.3	-1.3
Distance moved, locomotor task time 1	0.6	1.0	1.2	0.6	1.0	-1.0	1.1	1.1
Vertical activity count, locomotor time 1	0.6	1.4	1.5	1.1	1.2	-1.2	1.2	1.2
Time >=10cm from walls, locomotor time 2	0.4	0.7	0.7	0.8	0.8	-0.9	0.8	0.8
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.3	-0.2	0.5	-0.3	-0.4
Total resting periods, locomotor time 2	0.2	0.3	0.6	0.2	-0.4	0.8	-0.6	-0.7
Rest time, locomotor task time 2	0.5	0.7	1.0	-0.4	-0.8	0.9	-0.9	-1.0
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.5	0.0	-0.2	0.1	0.3
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.3	-0.0	-0.1	0.1	0.2
Light reinforcement 1	0.3	0.7	1.0	-1.0	-0.9	0.8	-0.8	-0.7
Light reinforcement 2	0.6	0.9	1.1	0.6	0.9	-1.0	1.0	1.1
Bone: marrow area	3.8	8.3	8.7	-2.9	-3.0	2.9	-2.8	-2.9
Bone: maximum diameter	1.3	2.4	4.8	-2.2	-1.5	1.3	-1.4	-1.2
Bone: maximum force	2.8	5.0	6.0	-2.4	-2.2	2.2	-2.2	-2.1
Bone: maximum moment	3.8	6.6	7.8	-2.8	-2.6	2.5	-2.5	-2.4
Mean time between licks in bursts	0.2	0.6	0.6	0.6	0.8	-0.8	0.8	0.8
Mean num. licks in bursts	0.1	0.2	0.3	0.5	-0.2	0.4	-0.3	-0.5
Cd content in liver	1.1	1.2	1.4	-0.9	-1.1	1.2	-1.1	-1.2
Co content in liver	0.3	0.4	0.5	-0.3	-0.6	0.7	-0.7	-0.7
Cu content in liver	1.1	1.4	2.1	-1.4	-1.2	1.0	-1.1	-1.0
Fe content in liver	0.1	0.2	0.7	-0.9	-0.3	0.1	-0.1	0.0
K content in liver	0.2	0.2	0.6	-0.8	-0.4	0.3	-0.4	-0.2
Mg content in liver	0.1	0.1	0.1	-0.3	0.1	-0.3	0.2	0.3
Mn content in liver	0.2	0.2	0.3	0.2	0.4	-0.5	0.5	0.5
Na content in liver	0.8	0.8	0.9	0.8	0.9	-0.9	0.9	1.0
Rb content in liver	2.5	2.9	3.6	-1.9	-1.7	1.7	-1.7	-1.6
Se content in liver	1.8	2.1	3.2	0.3	1.4	-1.7	1.6	1.8
Sr content in liver	4.1	3.6	3.8	2.0	1.9	-1.9	1.8	1.8
Zn content in liver	0.8	0.8	1.2	0.3	0.9	-1.1	1.0	1.1
Bone: minimum diameter	4.8	8.8	9.5	-3.1	-3.0	2.9	-2.9	-2.9
Time in familiar zone, hab. session 1	5.2	5.0	5.2	-2.2	-2.3	2.3	-2.2	-2.3
Time in novel zone, hab. session 1	2.5	2.5	3.0	1.2	1.6	-1.7	1.6	1.7
Total zone transitions, hab. session 1	3.4	4.8	4.9	-2.2	-2.2	2.2	-2.2	-2.2
Total locomotion distance, hab. session 1	1.0	1.4	1.5	-1.0	-1.1	1.2	-1.2	-1.2
Locomotion velocity, hab. session 1	0.6	0.8	1.0	-0.6	-0.8	1.0	-0.9	-1.0
Time in familiar zone, hab. session 2	0.9	0.9	1.1	-0.8	-1.0	1.0	-1.0	-1.0
Time in novel zone, hab. session 2	0.6	0.6	0.7	0.5	0.8	-0.8	0.8	0.9
Total zone transitions, hab. session 2	4.5	5.7	6.1	-2.5	-2.5	2.3	-2.4	-2.3
Total locomotion distance, hab. session 2	0.3	0.3	0.4	-0.4	-0.6	0.6	-0.6	-0.7
Locomotion velocity, hab. session 2	0.2	0.3	0.3	-0.4	-0.5	0.6	-0.5	-0.6
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.5	-0.3	0.1	-0.2	-0.2
Novelty place preference	0.2	0.2	0.4	-0.7	-0.5	0.4	-0.5	-0.4
Time in novel zone, NPP test	0.2	0.2	0.5	-0.7	-0.5	0.4	-0.5	-0.4
Total zone transitions, NPP test	0.4	0.6	0.8	-0.9	-0.8	0.7	-0.7	-0.7
Total locomotion distance, NPP test	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.2	-0.2
Locomotion velocity, NPP test	0.1	0.2	0.3	-0.6	-0.4	0.4	-0.4	-0.4
Intraocular pressure	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.2	-0.2
Delta distance traveled before/after self-admin	2.0	2.1	2.6	1.6	1.4	-1.6	1.4	1.3
Delta ambulatory time before/after self-admin	1.8	2.2	2.7	1.6	1.4	-1.6	1.4	1.3
Parametrial fat weight	2.6	6.2	6.8	2.6	2.5	-2.6	2.4	2.3
Pavlov. Cond. lever latency	0.0	0.0	0.2	0.4	0.1	0.0	0.0	-0.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.4	0.7	-0.8	0.8	0.8
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	0.6	0.4	-0.5	0.5	0.4
Pavlov. Cond. index score	0.1	0.1	0.2	-0.1	0.3	-0.5	0.4	0.5
Pavlov. Cond. latency score	0.1	0.2	0.3	0.1	0.4	-0.5	0.5	0.5
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.3	-0.1	-0.1	-0.0	0.1
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.2	-0.1	0.2	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	-0.4	-0.7	0.7	-0.8	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	-0.0	0.4	-0.5	0.5	0.5
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.5	-0.0	-0.2	0.1	0.2
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.2	-0.3
Pavlov. Cond. magazine entry latency	0.9	1.1	1.2	1.0	1.1	-1.1	1.0	1.1
Pavlov. Cond. change in total contacts	0.4	0.6	0.8	-0.5	-0.8	0.9	-0.9	-0.9
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1
Pavlov. Cond. latency score	0.3	0.4	0.5	0.7	0.7	-0.6	0.6	0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	-0.1	-0.0	-0.1	0.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	-0.8	-0.7	0.6	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	3.6	5.4	5.6	-2.3	-2.4	2.3	-2.3	-2.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.1	0.2	-0.2	0.2	0.2
Pavlov. Cond. response bias	0.3	0.4	0.5	-0.7	-0.7	0.6	-0.7	-0.6
Time in closed arm before self-admin	0.1	0.1	0.2	0.2	0.3	-0.5	0.3	0.4
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	0.1	0.0	0.0	0.0
Time in open arm before self-admin	0.0	0.0	0.1	0.1	-0.1	0.3	-0.1	-0.1
Time in open arm after self-admin	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.2	-0.2
Bone: periosteal estimation	3.6	7.6	8.6	-2.9	-2.8	2.7	-2.7	-2.6
Bone: periosteal perimeter	3.8	6.5	7.3	-2.7	-2.6	2.5	-2.5	-2.5
Bone: post-yield work	2.5	3.6	3.9	-1.7	-2.0	2.0	-1.9	-2.0
Progressive ratio test 1 active lever presses	0.7	0.9	1.3	-1.1	-1.0	0.8	-0.9	-0.8
Progressive ratio test 1 breakpoint	0.6	0.8	1.1	-1.0	-0.9	0.8	-0.8	-0.8
Progressive ratio test 1 inactive lever presses	1.0	1.4	2.5	-1.6	-1.1	1.1	-1.1	-0.9
Progressive ratio test 2 active lever presses	0.4	0.5	0.9	0.2	0.8	-0.7	0.7	1.0
Progressive ratio test 2 breakpoint	0.4	0.4	0.8	0.1	0.7	-0.6	0.6	0.9
Progressive ratio test 2 inactive lever presses	0.8	1.3	2.1	-1.4	-1.1	1.1	-1.1	-0.9
Incentive Sensitization - Responses	0.3	0.4	0.7	0.2	0.7	-0.6	0.6	0.8
Incentive Sensitization - Breakpoint	0.4	0.6	1.0	0.3	0.8	-0.7	0.7	1.0
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.8	0.9	0.6	-0.8	0.6	0.5
Progressive ratio	0.2	0.4	0.5	-0.5	-0.6	0.7	-0.5	-0.6
Food seeking constrained by brief footshock	3.3	4.0	4.9	-1.4	-2.0	2.2	-2.1	-2.2
Seeking ratio, punishment vs. effort	0.6	0.8	1.1	-0.6	-0.9	0.9	-1.0	-1.0
Retroperitoneal fat weight	5.8	24.6	25.4	5.0	5.0	-5.0	4.9	4.9
Reaction time number correct	0.1	0.2	0.7	-0.8	-0.3	0.2	-0.1	-0.0
Reaction time mean minus median	0.0	0.1	0.2	0.4	0.2	-0.1	0.1	0.0
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.1	-0.1
Reaction time num false alarms	0.2	0.3	0.4	-0.6	0.2	-0.6	0.4	0.6
Reaction time num false alarms AUC	0.2	0.2	0.4	-0.4	0.3	-0.6	0.4	0.6
Reaction time trials correct on left	0.1	0.2	0.7	-0.8	-0.3	0.2	-0.1	-0.0
Reaction time trials on left	0.1	0.2	0.7	-0.8	-0.3	0.2	-0.1	-0.0
Reaction time mean	0.1	0.1	0.3	0.6	0.1	-0.2	0.2	-0.1
Reaction time mean AUC	0.3	0.4	0.9	0.9	0.6	-0.6	0.6	0.4
Median of all reaction times	0.1	0.1	0.4	0.6	0.3	-0.3	0.3	0.1
Reaction time omissions	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1
Reaction time false alarm rate	0.2	0.3	0.5	0.2	0.4	-0.7	0.5	0.6
Reaction time premature initiation rate	0.3	0.5	1.2	1.1	0.7	-0.5	0.6	0.4
Reaction time premature initiations	0.2	0.3	0.5	0.7	0.6	-0.5	0.6	0.5
Std. dev. reaction times	0.1	0.1	0.3	0.5	0.2	-0.3	0.2	0.1
Reaction time trials completed	0.1	0.2	0.7	-0.8	-0.3	0.2	-0.1	-0.0
Reaction time trials AUC	0.1	0.1	0.7	-0.8	-0.2	0.1	-0.0	0.1
Run reversals in cocaine runway, females	1.3	1.3	2.5	1.6	1.1	-1.0	1.0	0.8
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.5	-0.4	0.1	-0.3	-0.2
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.4	0.3	-0.1	0.2	0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.7	0.8	0.7	-0.6	0.7	0.7
Latency to leave start box in cocaine runway, M	0.9	0.8	0.9	-1.0	-0.9	0.9	-0.9	-0.9
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.6	-0.3	0.2	-0.2	-0.2
Total sessions with >9 infusions	1.0	1.2	2.0	-1.4	-1.1	1.0	-1.0	-0.9
Short access day 1 total inactive lever presses	0.1	0.2	0.7	-0.8	-0.3	0.3	-0.3	-0.0
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.2	-0.1	0.3	-0.1	-0.2
Short access day 1 total infusions	0.1	0.1	0.3	-0.5	-0.2	0.2	-0.2	-0.0
Short access day 10 total infusions	0.1	0.1	0.3	-0.3	0.3	-0.4	0.3	0.5
Short access total infusions	0.1	0.1	0.2	-0.2	0.2	-0.3	0.3	0.4
Short access day 1 locomotion	0.2	0.2	0.6	-0.8	-0.4	0.4	-0.4	-0.2
Short access day 10 total locomotion	0.3	0.6	0.8	-0.4	-0.8	0.9	-0.8	-0.9
Short access total locomotion	0.4	0.5	0.7	-0.6	-0.7	0.8	-0.7	-0.7
One hour access (0.3 mA shock)	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.2	-0.2
Compulsive drug intake	0.6	0.7	1.0	-1.0	-0.8	0.9	-0.8	-0.7
One hour access (shock baseline)	0.7	1.0	1.3	0.8	1.0	-1.1	1.0	1.1
Social response proportion	0.1	0.1	0.1	-0.2	0.2	-0.4	0.3	0.4
Social responses	1.5	1.9	3.6	-1.9	-1.4	1.2	-1.2	-1.1
Social time	3.9	5.4	6.0	-2.2	-2.3	2.4	-2.3	-2.3
Soleus weight	0.0	0.0	0.1	-0.3	-0.0	-0.2	0.0	0.1
Bone: stiffness	2.4	3.9	5.7	-2.4	-2.0	1.8	-1.9	-1.7
Tibialis anterior weight	0.7	2.2	3.5	0.3	1.4	-1.9	1.5	1.8
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Time to tail flick, test, before self-admin	1.0	1.0	1.4	-0.4	-1.0	1.2	-1.0	-1.2
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.6	0.5	-0.2	0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.0	0.0	0.1	0.0	0.0
Delta time to tail flick, test, before/after SA	0.5	0.5	0.7	0.5	0.8	-0.6	0.7	0.8
Tibia length	3.9	10.8	14.3	-3.8	-3.4	3.1	-3.1	-3.0
Ambulatory time before self-admin	3.2	4.8	5.4	-2.1	-2.2	2.3	-2.2	-2.1
Ambulatory time after self-admin	0.6	0.7	1.1	-0.5	-0.9	0.8	-0.9	-1.1
Bone: tissue strength	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.2	-0.3
Total heroin consumption	0.0	0.0	0.1	-0.0	0.2	-0.2	0.2	0.2
Bone: trabecular number	0.2	0.3	0.4	-0.5	-0.5	0.6	-0.6	-0.6
Bone: trabecular spacing	0.0	0.0	0.0	0.1	0.1	-0.1	0.1	0.1
Bone: trabecular thickness	0.0	0.0	0.1	-0.4	-0.0	-0.0	-0.0	0.1
Bone: trabecular tissue density	2.7	4.0	4.1	1.9	2.0	-2.0	2.0	2.0
Water consumed over 24 hours	0.9	1.3	1.6	-0.7	-1.2	1.2	-1.2	-1.3
Number of responses in last shaping day	0.8	0.8	1.3	0.4	0.9	-1.0	1.0	1.1