Hub : Genes

Sult1e1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Sult1e1	0.23	0.1	0.0e+00	0.13	0.14	0.13	0.14	7.6e-14	6.5e-15	2.5e-14	1.6e-15
2	Liver	intron excision ratio	chr14_20433983_20435753	0.05	0.04	9.8e-05	0.01	0.02	0.02	0.01	2.1e-02	2.2e-03	4.3e-03	1.1e-02
3	Liver	intron excision ratio	chr14_20430309_20433856	0.04	0.03	1.9e-04	0.02	0.02	0.02	0.02	2.1e-03	1.5e-03	3.2e-03	3.3e-03
4	Liver	gene expression	Sult1e1	0.59	0.11	0.0e+00	0.46	0.43	0.46	0.46	3.5e-57	1.1e-52	6.0e-57	3.6e-57
5	Adipose	gene expression	Sult1e1	0.02	0.02	7.2e-03	0.01	0.01	0.01	0.02	8.5e-03	1.2e-02	9.4e-03	6.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.2	0.4	0.5	0.7	-0.6	0.5	0.6	-0.7
Area under the delay curve	0.0	0.1	0.1	-0.3	-0.2	0.3	0.1	0.1
BMI with tail	1.5	4.8	7.2	1.9	-2.5	2.7	2.0	-1.8
BMI without tail	0.0	0.1	0.2	-0.2	-0.3	0.4	-0.2	0.4
Body weight	0.1	0.5	1.0	0.5	-0.9	1.0	0.7	-0.1
Weight adjusted by age	1.5	1.7	2.7	1.4	-1.1	1.0	1.3	-1.7
Bone surface	0.0	0.1	0.2	0.5	-0.0	-0.1	0.3	0.1
Bone volume	0.1	0.1	0.2	-0.3	0.4	-0.5	-0.3	0.4
Breakpoint value in progressive ratio session	0.2	0.2	0.4	-0.6	0.3	-0.2	-0.4	0.4
Number of licking bursts	0.1	0.1	0.2	0.5	-0.3	0.3	0.2	-0.4
Context. condit. distance diff. score	0.3	0.4	1.0	-0.3	0.8	-1.0	-0.1	0.6
Locomotion velocity, session 1	0.9	1.0	1.7	0.6	-1.1	1.3	0.7	-1.0
Locomotion distance, session 1	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.6	0.2
Locomotion velocity, session 2	0.1	0.1	0.1	-0.3	0.4	-0.4	-0.3	0.3
Locomotion distance, session 2	0.2	0.2	0.3	-0.6	0.5	-0.4	-0.5	0.3
Locomotion velocity, session 3	0.5	0.6	0.8	-0.8	0.9	-0.9	-0.9	-0.0
Locomotion distance, session 3	0.1	0.1	0.3	0.0	0.1	-0.1	-0.1	-0.6
Stereotopy head waving bouts, day 3	0.6	0.7	1.2	0.6	-0.9	0.9	0.7	-1.1
Stereotopy head waving duration, day 3	0.1	0.1	0.4	0.0	-0.3	0.3	0.2	-0.6
Locomotion velocity, session 7	2.3	2.5	3.2	-1.8	1.5	-1.4	-1.8	1.4
Locomotion distance, session 7	1.5	2.0	2.2	-1.5	1.4	-1.3	-1.4	1.5
Stereotopy head waving bouts, day 7	0.2	0.3	0.3	0.6	-0.5	0.4	0.5	-0.5
Stereotopy head waving duration, day 7	0.3	0.4	0.7	0.4	-0.7	0.8	0.4	-0.7
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	0.2	-0.2	0.0	-0.2
Locomotion distance, session 8	1.0	1.4	2.3	-1.0	1.4	-1.5	-0.8	1.1
Degree of sensitization distance	2.0	2.0	3.7	-1.4	1.2	-1.2	-1.1	1.9
Degree of sensitization stereotypy	0.0	0.0	0.1	0.3	-0.1	0.1	0.1	-0.0
Conditioned locomotion	0.3	0.3	0.4	0.6	-0.6	0.6	0.6	-0.4
Cocaine response after cond. corrected	0.7	0.8	1.0	-0.8	0.9	-0.8	-1.0	0.8
Cocaine response after cond. not corrected	0.7	0.8	1.0	-0.6	1.0	-1.0	-1.0	0.8
Cocaine response before conditioning	0.1	0.1	0.3	0.6	-0.2	0.1	0.3	-0.3
Saline control response	0.8	1.1	1.2	-0.9	1.1	-1.1	-1.1	1.0
Bone: connectivity density	0.6	1.0	1.2	1.1	-1.0	1.0	0.9	-1.0
Bone: cortical apparent density	0.2	0.2	0.4	-0.4	-0.3	0.6	-0.3	-0.6
Bone: cortical area	0.5	0.7	2.1	-0.7	0.6	-0.6	-0.6	1.4
Bone: cortical porosity	2.0	2.2	3.1	1.8	-1.4	1.3	1.6	-1.3
Bone: cortical porosity	3.1	3.3	4.3	2.1	-1.8	1.7	2.0	-1.5
Bone: cortical thickness	0.3	0.5	0.7	0.7	-0.8	0.8	0.7	-0.1
Bone: cortical thickness	0.2	0.2	0.4	0.0	0.5	-0.7	-0.3	0.3
Bone: cortical tissue density	0.2	0.3	0.6	-0.3	-0.4	0.7	-0.3	-0.8
Condit. Reinf. active minus inactive responses	0.7	0.8	1.0	0.9	-1.0	1.0	0.9	-0.6
Condit. Reinf. active-inactive response ratio	3.2	3.4	4.4	2.1	-1.9	1.7	2.1	-1.4
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.2	0.1
Condit. Reinf. inactive responses	2.4	2.8	3.7	-1.7	1.7	-1.6	-1.9	1.4
Incentive salience index mean	0.1	0.1	0.1	0.2	-0.3	0.4	0.2	-0.1
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.2	0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.4	0.2	-0.1	-0.6	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	-0.3	0.3	-0.3	-0.7	0.1
Condit. Reinf. active responses	0.1	0.2	0.3	-0.5	0.4	-0.4	-0.5	-0.2
Condit. Reinf. inactive responses	0.4	0.5	0.6	-0.8	0.8	-0.8	-0.5	0.5
Condit. Reinf. lever presses	0.5	0.6	1.2	-0.6	0.9	-1.1	-0.7	0.7
Condit. Reinf. lever reinforcers received	0.2	0.2	0.3	-0.5	0.5	-0.5	-0.5	-0.2
Conditioned reinforcement - actives	0.1	0.1	0.3	0.2	-0.1	0.1	0.5	0.3
Conditioned reinforcement - inactives	1.2	1.3	1.7	-1.1	1.3	-1.3	-1.2	0.8
Conditioned locomotion	0.1	0.1	0.3	-0.1	0.2	-0.3	0.1	0.6
Patch foraging indifference point 0 sec	0.3	0.4	0.7	-0.8	0.7	-0.6	-0.8	0.3
Patch foraging indifference point AUC	2.7	3.1	4.4	-2.1	1.6	-1.5	-1.9	1.7
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.1	-0.4	0.5	0.2	-0.1
Delay disc. indifference point, 16s delay	0.6	0.6	1.3	0.3	-1.0	1.1	0.6	-0.6
Delay disc. indifference point, 2s delay	3.2	3.6	4.7	-2.1	1.7	-1.6	-1.8	2.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.1	-0.3	0.3	0.5	-0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	-0.8	0.3	-0.1	-0.6	0.7
Delay disc. indifference point, 8s delay	1.4	1.5	2.1	0.9	-1.3	1.4	1.2	-1.1
Indifference point function ln k	0.9	1.2	2.0	1.4	-1.0	0.8	1.2	-0.9
Indifference point function log k	0.9	1.2	2.0	1.4	-1.0	0.8	1.2	-0.9
Patch foraging total patch changes 0 sec	0.3	0.4	0.7	-0.8	0.7	-0.6	-0.8	0.3
Patch foraging total patch changes 12 sec	0.5	0.6	1.4	-1.2	0.5	-0.3	-0.6	1.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.4	0.2	-0.1	-0.5	-0.2
Patch foraging total patch changes 24 sec	0.9	1.1	1.8	-1.4	1.1	-1.0	-1.1	0.8
Patch foraging total patch changes 6 sec	1.4	2.0	3.0	-1.7	1.3	-1.2	-1.5	1.3
Patch foraging time to switch 0 sec	4.0	6.2	6.4	2.4	-2.5	2.5	2.5	-2.4
Patch foraging water rate 0 sec	2.2	3.5	4.7	-1.9	1.8	-1.8	-1.7	2.2
Patch foraging water rate 12 sec	0.7	1.0	1.8	-0.7	1.0	-1.2	-0.8	1.3
Patch foraging water rate 18 sec	2.4	3.2	4.1	-1.5	1.9	-2.0	-1.6	1.8
Patch foraging water rate 24 sec	1.6	2.3	3.4	-1.0	1.6	-1.8	-1.2	1.7
Patch foraging water rate 6 sec	1.1	1.6	3.4	-1.0	1.1	-1.1	-1.0	1.8
Seeking ratio, delayed vs. immediate footshock	1.0	1.2	1.6	-1.0	1.2	-1.3	-1.2	0.7
Distance traveled before self-admin	0.6	0.7	1.1	-0.8	0.8	-0.8	-0.6	1.1
Distance traveled after self-admin	3.2	3.6	4.8	-1.7	2.1	-2.2	-1.8	1.5
Extensor digitorum longus weight	11.3	44.6	49.7	7.0	-6.8	6.7	6.6	-6.3
Bone: elastic displacement	0.5	0.5	1.0	1.0	-0.5	0.3	0.8	-0.8
Bone: elastic work	0.4	0.5	1.1	1.1	-0.3	0.2	0.4	-1.0
Bone: endosteal estimation	2.0	4.4	5.1	-2.0	2.2	-2.3	-1.9	2.1
Bone: endosteal perimeter	0.5	0.9	1.3	-0.7	1.0	-1.1	-0.8	1.1
Epididymis fat weight	0.1	0.1	0.3	-0.2	-0.4	0.6	0.3	0.3
Delta time in closed arm before/after self-admin	1.3	1.3	1.6	1.2	-1.2	1.2	1.2	-0.6
Delta time in open arm before/after self-admin	1.1	1.1	1.7	-1.3	1.1	-1.0	-1.2	0.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	-0.1	0.0	0.2	-0.2
Delay discount exponential model param	0.0	0.1	0.2	0.4	0.0	-0.2	0.1	-0.2
Extinction: sum of active levers before priming	0.5	0.5	0.7	-0.6	0.8	-0.8	-0.8	-0.0
Active lever presses in extinction session 6	0.7	0.6	0.8	-0.9	0.8	-0.8	-0.9	0.5
Bone: final force	0.1	0.2	0.6	-0.3	0.3	-0.4	-0.3	0.7
Bone: final moment	0.1	0.2	0.7	-0.3	0.3	-0.4	-0.3	0.9
Food consumed during 24 hour testing period	2.6	3.2	3.8	-1.6	1.9	-2.0	-1.9	1.5
Glucose	1.1	1.7	1.8	-1.3	1.3	-1.3	-1.2	1.3
Heart weight	0.4	0.5	1.1	0.6	-0.8	0.7	1.0	0.2
Delay discount hyperbolic model param	0.2	0.2	0.5	0.7	-0.3	0.1	0.4	-0.6
Intermittent access intake day 1-15 change	1.1	1.0	1.9	1.3	-0.9	0.8	1.4	-0.3
Intermittent access intake escalation	0.4	0.4	0.8	0.8	-0.5	0.4	0.9	-0.0
Intermittent access intake escalation 2	0.2	0.2	0.6	-0.3	0.4	-0.5	-0.0	0.8
Intermitt. access day 1 inactive lever presses	0.9	1.0	1.6	-1.3	1.1	-1.0	-1.1	0.3
Intermitt. access day 15 inactive lever presses	1.6	1.7	2.1	-1.4	1.4	-1.4	-1.5	0.8
Intermitt. access escalation Index	1.6	1.4	2.2	1.3	-1.1	1.0	1.0	-1.5
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.0	0.2	-0.2	-0.1	-0.3
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.1	0.3	-0.4	0.1	0.3
Intermittent access terminal intake (last 3 days)	0.4	0.5	0.8	-0.4	0.7	-0.9	-0.2	0.8
Intermittent access total infusions	0.0	0.1	0.2	0.0	0.3	-0.4	-0.1	0.2
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	0.2	-0.2	-0.1	0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.2	0.3	-0.4	0.0	0.5
Intermittent access total locomotion	0.0	0.1	0.1	0.2	-0.2	0.1	0.3	0.2
Intermittent access standard deviation	0.3	0.3	1.0	-0.3	0.5	-0.6	-0.2	1.0
Left kidney weight	0.5	1.4	2.5	-0.9	1.1	-1.3	-0.8	1.6
Right kidney weight	0.6	1.8	4.0	-1.3	1.1	-1.1	-1.0	2.0
Cocaine induced anxiety	0.1	0.1	0.1	0.3	-0.4	0.3	0.3	-0.1
Post-drug Anxiety	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.1	0.2
Baseline Anxiety	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.3	-0.1
Tail length	0.1	0.5	0.7	-0.5	0.7	-0.9	-0.6	0.6
Length with tail	0.8	2.8	3.5	-1.6	1.7	-1.8	-1.3	1.9
Length without tail	0.3	0.6	1.0	-1.0	0.8	-0.7	-0.5	0.9
Times rat made contact with spout	0.1	0.1	0.3	-0.4	0.3	-0.2	-0.6	0.3
Lifetime Intake	0.0	0.0	0.1	0.3	0.0	-0.1	0.1	-0.1
Liver weight, left	1.8	2.9	4.4	-2.0	1.6	-1.3	-2.1	1.3
Liver weight, right	2.4	4.0	5.3	-2.3	2.0	-1.8	-2.3	1.6
Locomotor activity	0.5	0.8	1.3	-0.7	1.0	-1.1	-0.4	1.1
Locomotor testing distance	0.2	0.3	0.9	-0.1	0.8	-1.0	-0.0	0.4
Locomotor testing rearing	0.1	0.2	0.4	0.1	0.4	-0.7	0.1	0.6
Locomotion in novel chamber	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	-0.1
Locomotion in novel chamber post-restriction	0.7	0.8	1.4	-1.0	0.9	-0.8	-1.2	0.7
Fecal boli incidents, locomotor time 1	1.2	1.4	2.1	1.4	-1.0	0.8	1.3	-1.2
Change in fecal boli incidents, locomotor task	0.3	0.3	1.2	0.2	-0.2	0.3	0.2	-1.1
Time >=10cm from walls, locomotor time 1	1.8	1.8	2.6	1.4	-1.2	1.2	1.2	-1.6
Bouts of movement, locomotor time 1	1.1	1.2	1.5	1.1	-1.1	1.0	1.0	-1.2
Total resting periods, locomotor time 1	0.8	0.9	1.4	1.0	-0.9	0.9	0.8	-1.2
Rest time, locomotor task time 1	0.5	0.6	1.5	-0.2	1.0	-1.2	-0.7	0.1
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.0	-0.4	0.6	0.3	0.2
Vertical activity count, locomotor time 1	0.7	0.7	1.7	-1.2	0.1	0.2	-0.6	1.3
Time >=10cm from walls, locomotor time 2	0.3	0.4	1.0	0.7	-0.3	0.3	0.4	-1.0
Bouts of movement, locomotor time 2	0.1	0.1	0.1	-0.4	0.3	-0.3	-0.3	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.2	-0.4
Rest time, locomotor task time 2	0.5	0.6	1.2	-0.2	0.9	-1.1	-0.6	-0.6
Distance moved, locomotor task time 2	1.2	1.4	2.2	1.1	-1.4	1.5	1.2	-0.3
Vertical activity count, locomotor time 2	0.2	0.3	0.9	-0.3	-0.3	0.4	-0.1	0.9
Light reinforcement 1	0.7	1.2	1.4	-1.2	1.0	-1.0	-1.1	1.1
Light reinforcement 2	0.1	0.1	0.4	0.2	-0.2	0.2	0.0	-0.6
Bone: marrow area	1.9	4.1	4.9	-2.0	2.1	-2.2	-1.8	2.0
Bone: maximum diameter	0.1	0.2	0.8	-0.2	-0.1	0.1	-0.1	0.9
Bone: maximum force	0.4	0.7	1.3	-0.6	0.7	-0.9	-0.6	1.1
Bone: maximum moment	0.5	0.8	1.8	-0.6	0.8	-1.0	-0.7	1.3
Mean time between licks in bursts	4.4	6.2	7.0	2.5	-2.6	2.6	2.6	-2.1
Mean num. licks in bursts	0.7	0.8	1.2	-1.1	0.9	-0.7	-0.9	0.9
Cd content in liver	2.1	2.3	2.9	1.7	-1.5	1.5	1.4	-1.3
Co content in liver	0.0	0.0	0.1	0.0	0.2	-0.2	-0.2	-0.0
Cu content in liver	0.6	0.8	1.3	-0.9	0.7	-0.7	-0.9	1.1
Fe content in liver	0.6	0.7	1.3	0.6	-1.0	1.1	0.9	-0.5
K content in liver	1.2	1.2	2.1	-1.5	0.9	-0.6	-1.3	0.9
Mg content in liver	1.2	1.2	2.3	-1.5	0.8	-0.6	-1.4	0.9
Mn content in liver	0.0	0.1	0.2	-0.2	-0.2	0.2	0.4	0.2
Na content in liver	0.7	0.7	1.2	-1.1	0.7	-0.5	-1.1	0.7
Rb content in liver	0.7	0.9	1.2	0.8	-1.1	1.1	1.0	-0.8
Se content in liver	0.1	0.1	0.3	-0.5	0.2	-0.1	-0.3	0.3
Sr content in liver	0.2	0.2	0.6	0.6	-0.3	0.0	0.8	-0.2
Zn content in liver	0.8	0.9	1.5	-1.0	1.0	-0.9	-1.2	0.4
Bone: minimum diameter	6.5	12.2	15.0	-3.4	3.4	-3.5	-3.3	3.9
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.3	0.1
Time in novel zone, hab. session 1	0.6	0.6	1.2	0.7	-1.0	1.1	0.5	-0.5
Total zone transitions, hab. session 1	0.3	0.4	0.6	-0.6	0.6	-0.5	-0.8	0.6
Total locomotion distance, hab. session 1	2.1	3.0	3.7	-1.8	1.9	-1.9	-1.7	1.2
Locomotion velocity, hab. session 1	1.8	2.5	3.4	-1.6	1.8	-1.8	-1.5	1.0
Time in familiar zone, hab. session 2	0.2	0.2	0.6	0.5	-0.2	0.3	0.2	-0.8
Time in novel zone, hab. session 2	0.2	0.2	0.9	-0.3	-0.3	0.3	0.1	1.0
Total zone transitions, hab. session 2	0.0	0.1	0.2	0.1	0.3	-0.4	-0.2	-0.0
Total locomotion distance, hab. session 2	0.7	0.9	1.6	-0.7	1.1	-1.3	-0.8	0.6
Locomotion velocity, hab. session 2	0.7	0.9	1.6	-0.7	1.1	-1.3	-0.9	0.5
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.5	-0.0	0.2	-0.5	0.3
Novelty place preference	0.1	0.1	0.2	-0.2	-0.3	0.5	-0.2	0.1
Time in novel zone, NPP test	0.1	0.1	0.2	-0.5	-0.1	0.3	-0.4	0.3
Total zone transitions, NPP test	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.3	0.0
Total locomotion distance, NPP test	0.2	0.3	0.6	-0.3	0.7	-0.8	-0.5	0.1
Locomotion velocity, NPP test	0.1	0.1	0.2	0.1	0.4	-0.5	-0.2	-0.2
Intraocular pressure	0.7	1.0	1.5	1.2	-1.1	1.1	1.1	-0.2
Delta distance traveled before/after self-admin	0.4	0.4	0.6	-0.5	0.7	-0.8	-0.7	0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.2	0.4	-0.5	-0.4	-0.1
Parametrial fat weight	1.2	2.4	3.3	-1.8	1.5	-1.3	-1.7	1.3
Pavlov. Cond. lever latency	1.2	1.5	2.7	1.5	-1.0	0.9	1.1	-1.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.2	0.3	-0.3	-0.2	0.2
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	-0.5	0.2	-0.2	-0.2	0.8
Pavlov. Cond. index score	0.4	0.5	0.9	-0.9	0.5	-0.4	-0.6	0.9
Pavlov. Cond. latency score	0.6	0.7	1.3	-1.0	0.6	-0.5	-0.7	1.1
Pavlov. Cond. lever contacts	1.4	1.7	3.0	-1.5	1.0	-0.9	-1.1	1.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	0.2	-0.3	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	-1.0	0.4	-0.4	-0.7	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	-1.0	0.6	-0.5	-0.7	0.9
Pavlov. Cond. response bias	0.5	0.6	0.9	-0.9	0.6	-0.5	-0.7	1.0
Pavlov. Cond. lever latency	0.1	0.2	0.5	-0.5	0.1	0.1	-0.5	0.7
Pavlov. Cond. magazine entry latency	0.9	1.1	1.7	1.2	-0.8	0.7	1.1	-1.3
Pavlov. Cond. change in total contacts	0.4	0.5	1.0	0.9	-0.4	0.2	0.8	-1.0
Pavlov. Cond. index score	0.7	0.8	1.5	1.1	-0.6	0.4	1.0	-1.2
Pavlov. Cond. latency score	0.9	1.2	1.8	1.4	-0.8	0.5	1.2	-1.3
Pavlov. Cond. lever contacts	0.1	0.1	0.4	0.4	0.1	-0.3	0.3	-0.6
Pavlov. Cond. magazine entry number	1.5	1.8	2.7	-1.6	1.1	-0.9	-1.4	1.5
Pavlov. Cond. intertrial magazine entries	1.6	2.1	3.0	-1.7	1.3	-1.1	-1.6	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.4	1.0	-0.5	0.3	0.9	-1.2
Pavlov. Cond. response bias	0.5	0.7	1.6	1.0	-0.5	0.3	0.8	-1.3
Time in closed arm before self-admin	0.6	0.7	1.0	-1.0	1.0	-1.0	-0.7	0.4
Time in closed arm after self-admin	0.2	0.2	0.5	0.5	-0.3	0.1	0.7	-0.0
Time in open arm before self-admin	0.7	0.8	1.3	1.1	-0.9	0.7	1.1	0.2
Time in open arm after self-admin	0.9	1.0	1.7	-1.3	0.9	-0.7	-1.3	0.5
Bone: periosteal estimation	1.1	2.3	3.6	-1.4	1.4	-1.5	-1.3	1.9
Bone: periosteal perimeter	0.6	1.0	1.7	-0.7	0.9	-1.0	-0.9	1.3
Bone: post-yield work	0.2	0.3	0.5	-0.6	0.4	-0.4	-0.4	0.7
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.3	-0.1	0.0	0.2	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	-0.2	0.1	0.4	0.0
Progressive ratio test 1 inactive lever presses	2.4	2.6	3.5	-1.8	1.7	-1.5	-1.9	1.1
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.3	0.2	-0.3	-0.1	0.3
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.1	0.1	-0.2	0.0	0.4
Progressive ratio test 2 inactive lever presses	0.9	1.0	1.5	-1.0	1.2	-1.2	-1.1	0.5
Incentive Sensitization - Responses	0.0	0.0	0.1	0.1	-0.1	0.1	0.3	-0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.0	-0.0	0.0	0.2	-0.1
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.3	-0.7	1.0	-0.9	-1.1	0.1
Progressive ratio	0.5	0.6	0.7	0.9	-0.7	0.6	0.8	-0.8
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.5	-0.3	0.3	0.1	-0.3
Seeking ratio, punishment vs. effort	0.4	0.5	0.8	-0.8	0.6	-0.5	-0.9	0.7
Retroperitoneal fat weight	0.2	0.8	1.8	-1.2	0.4	-0.2	-0.6	1.3
Reaction time number correct	0.1	0.1	0.7	0.2	-0.1	-0.1	0.2	0.8
Reaction time mean minus median	0.7	1.0	1.4	0.9	-1.1	1.2	0.7	-1.0
Reaction time mean minus median AUC	0.6	0.7	1.4	0.6	-1.0	1.2	0.5	-0.7
Reaction time num false alarms	0.3	0.4	1.4	-0.7	0.1	0.0	-0.4	1.2
Reaction time num false alarms AUC	0.1	0.2	0.4	-0.3	-0.3	0.4	-0.1	0.6
Reaction time trials correct on left	0.1	0.1	0.7	0.2	-0.1	-0.1	0.2	0.8
Reaction time trials on left	0.1	0.2	0.6	0.2	-0.1	-0.0	0.3	0.8
Reaction time mean	0.8	1.1	1.5	0.9	-1.1	1.2	0.9	-1.1
Reaction time mean AUC	0.6	0.8	1.1	0.7	-1.0	1.1	0.8	-0.9
Median of all reaction times	0.7	1.0	1.2	0.8	-1.0	1.1	0.9	-1.0
Reaction time omissions	1.4	2.0	2.4	1.5	-1.5	1.4	1.4	-1.1
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.2	0.2
Reaction time premature initiation rate	0.2	0.3	0.5	-0.7	0.5	-0.5	-0.7	-0.1
Reaction time premature initiations	0.3	0.4	0.6	-0.7	0.5	-0.5	-0.7	0.5
Std. dev. reaction times	0.5	0.7	1.0	0.7	-0.9	1.0	0.7	-0.8
Reaction time trials completed	0.1	0.2	0.6	0.2	-0.1	-0.0	0.3	0.8
Reaction time trials AUC	0.1	0.2	0.6	0.3	-0.3	0.1	0.4	0.8
Run reversals in cocaine runway, females	4.2	4.1	6.3	-2.1	1.9	-1.9	-1.6	2.5
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.3	-0.4	0.4	0.5	-0.5
Latency to leave start box in cocaine runway	2.2	2.4	3.9	-1.5	1.7	-1.7	-2.0	0.5
Latency to leave start box in cocaine runway, F	3.9	4.3	6.0	-2.2	2.2	-2.1	-2.5	1.2
Latency to leave start box in cocaine runway, M	0.4	0.4	0.9	0.7	-0.4	0.3	0.3	-1.0
Std. dev. time between licks in bursts	1.1	1.3	1.7	1.1	-1.1	1.0	1.3	-1.2
Total sessions with >9 infusions	1.7	1.9	2.9	1.7	-1.3	1.2	1.3	-1.3
Short access day 1 total inactive lever presses	1.1	1.3	2.0	-0.9	1.3	-1.4	-1.2	0.5
Short access day 10 total inactive lever presses	1.2	1.3	1.7	-0.9	1.3	-1.3	-1.3	0.8
Short access day 1 total infusions	0.1	0.1	0.1	-0.0	0.2	-0.2	-0.4	0.3
Short access day 10 total infusions	0.2	0.2	0.8	0.6	-0.1	0.1	0.1	-0.9
Short access total infusions	0.4	0.4	0.7	0.8	-0.5	0.5	0.4	-0.8
Short access day 1 locomotion	0.1	0.1	0.1	0.4	-0.3	0.2	0.4	0.0
Short access day 10 total locomotion	0.2	0.2	0.4	0.3	-0.5	0.6	0.4	-0.1
Short access total locomotion	0.5	0.5	0.6	0.8	-0.7	0.7	0.7	-0.4
One hour access (0.3 mA shock)	0.2	0.2	0.5	-0.1	0.6	-0.7	-0.4	0.1
Compulsive drug intake	0.2	0.2	0.6	-0.2	0.1	0.1	-0.8	-0.7
One hour access (shock baseline)	0.1	0.1	0.2	-0.1	0.2	-0.3	0.2	0.5
Social response proportion	1.5	1.6	3.2	-1.5	1.2	-1.0	-1.8	0.4
Social responses	0.7	1.0	1.5	-1.2	0.9	-0.8	-1.1	0.8
Social time	0.7	0.9	1.3	-1.1	1.0	-0.9	-1.1	0.5
Soleus weight	0.3	0.8	1.3	1.1	-0.7	0.6	1.1	-0.8
Bone: stiffness	1.2	1.9	3.7	-1.5	1.0	-1.0	-1.2	1.9
Tibialis anterior weight	4.4	14.9	17.3	4.1	-4.2	4.1	4.0	-2.8
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.0	-0.7	0.8	-0.8	-0.7	1.0
Time to tail flick, vehicle, after self-admin	1.3	1.4	2.4	-0.9	1.2	-1.3	-0.6	1.6
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.3	0.1	-0.1	0.0	0.2
Time to tail flick, test, after self-admin	2.6	2.7	4.8	-1.6	1.5	-1.5	-1.3	2.2
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.7	0.5	-0.5	-0.3	0.8
Delta time to tail flick, test, before/after SA	1.3	1.1	2.1	-1.0	0.9	-0.9	-1.0	1.4
Tibia length	0.2	0.5	0.9	-0.8	0.6	-0.6	-0.6	1.0
Ambulatory time before self-admin	0.8	0.9	1.2	-1.0	0.9	-0.9	-0.7	1.1
Ambulatory time after self-admin	3.1	3.4	4.5	-1.7	2.0	-2.1	-1.9	1.4
Bone: tissue strength	1.0	1.0	1.1	-1.0	0.9	-0.9	-1.0	1.1
Total heroin consumption	1.9	2.2	2.4	-1.4	1.5	-1.6	-1.5	1.5
Bone: trabecular number	0.2	0.3	0.7	0.4	-0.6	0.6	0.4	-0.8
Bone: trabecular spacing	0.1	0.2	0.3	-0.3	-0.3	0.5	0.0	0.6
Bone: trabecular thickness	0.1	0.1	0.3	-0.2	0.5	-0.6	-0.3	-0.1
Bone: trabecular tissue density	0.3	0.5	0.8	0.6	-0.9	0.9	0.7	-0.3
Water consumed over 24 hours	1.9	2.3	2.7	-1.3	1.5	-1.5	-1.7	1.4
Number of responses in last shaping day	0.6	0.6	0.9	0.8	-0.8	0.9	0.5	-1.0