Hub : Genes

Sult1e1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Sult1e1	0.52	0.13	0.0e+00	0.27	0.3	0.32	0.32	5.5e-30	4.8e-33	4.7e-36	3.8e-36
2	Liver	intron excision ratio	chr14_20713137_20714909	0.09	0.07	9.0e-08	0.07	0.06	0.08	0.07	7.2e-08	8.8e-07	8.8e-09	1.8e-08
3	Liver	gene expression	Sult1e1	0.55	0.09	0.0e+00	0.44	0.43	0.46	0.46	2.0e-53	2.8e-52	2.7e-57	4.5e-57
4	Liver	intron excision ratio	chr14_20709460_20713011	0.07	0.06	1.7e-06	0.07	0.04	0.05	0.05	8.5e-08	3.2e-05	3.2e-06	1.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.0	0.1	0.3	0.1	0.1	-0.1
Area under the delay curve	0.0	0.0	0.0	-0.2	-0.0	0.0	-0.0
BMI with tail	1.8	6.1	7.2	2.4	2.4	2.7	-2.4
BMI without tail	1.0	5.1	5.4	2.1	2.2	2.3	-2.3
Body weight	0.0	0.2	0.4	0.3	0.1	0.6	-0.4
Weight adjusted by age	0.5	1.4	1.7	1.3	1.0	1.1	-1.3
Bone surface	0.0	0.1	0.1	-0.0	-0.2	-0.3	0.2
Bone volume	0.3	0.7	0.8	-0.8	-0.8	-0.9	0.8
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.3	-0.2	-0.3	0.1
Number of licking bursts	0.0	0.1	0.3	0.5	0.3	0.2	-0.3
Context. condit. distance diff. score	0.2	0.3	0.4	-0.6	-0.4	-0.5	0.5
Locomotion velocity, session 1	0.9	1.0	1.0	1.0	1.0	1.0	-0.9
Locomotion distance, session 1	0.2	0.2	0.3	-0.5	-0.4	-0.5	0.4
Locomotion velocity, session 2	0.1	0.1	0.1	-0.3	-0.3	-0.2	0.3
Locomotion distance, session 2	0.1	0.2	0.2	-0.4	-0.4	-0.5	0.5
Locomotion velocity, session 3	0.3	0.3	0.5	-0.6	-0.5	-0.7	0.3
Locomotion distance, session 3	0.0	0.0	0.0	-0.1	0.0	-0.2	0.1
Stereotopy head waving bouts, day 3	0.7	0.8	0.9	0.8	0.9	0.9	-1.0
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.4	0.5	0.4	-0.6
Locomotion velocity, session 7	2.7	3.0	3.2	-1.8	-1.7	-1.8	1.6
Locomotion distance, session 7	2.5	3.2	3.9	-1.8	-1.8	-1.7	2.0
Stereotopy head waving bouts, day 7	0.8	0.9	1.2	0.9	0.9	0.8	-1.1
Stereotopy head waving duration, day 7	0.9	1.1	1.5	0.9	1.0	1.0	-1.2
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	0.1	0.1	-0.2
Locomotion distance, session 8	0.8	1.1	1.3	-1.1	-0.9	-1.1	1.1
Degree of sensitization distance	2.4	2.6	2.9	-1.7	-1.7	-1.3	1.7
Degree of sensitization stereotypy	0.2	0.3	0.4	0.5	0.5	0.3	-0.7
Conditioned locomotion	0.4	0.5	0.6	0.7	0.8	0.7	-0.6
Cocaine response after cond. corrected	0.5	0.8	1.0	-0.8	-0.9	-1.0	0.9
Cocaine response after cond. not corrected	0.5	0.7	1.0	-0.7	-0.8	-1.0	0.8
Cocaine response before conditioning	0.1	0.2	0.2	0.5	0.4	0.3	-0.5
Saline control response	0.4	0.5	0.7	-0.8	-0.6	-0.8	0.6
Bone: connectivity density	0.2	0.3	0.6	0.8	0.5	0.4	-0.5
Bone: cortical apparent density	0.1	0.1	0.1	0.3	0.3	0.3	-0.3
Bone: cortical area	0.4	0.7	0.9	-1.0	-0.8	-0.7	0.8
Bone: cortical porosity	1.5	1.6	2.0	1.4	1.4	1.0	-1.2
Bone: cortical porosity	2.8	3.0	3.4	1.9	1.8	1.7	-1.6
Bone: cortical thickness	0.1	0.2	0.3	0.4	0.4	0.6	-0.3
Bone: cortical thickness	0.2	0.2	0.5	-0.4	-0.4	-0.7	0.3
Bone: cortical tissue density	0.1	0.1	0.2	0.3	0.4	0.4	-0.4
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	0.6	0.5	0.8	-0.5
Condit. Reinf. active-inactive response ratio	2.0	2.1	2.9	1.5	1.3	1.7	-1.3
Condit. Reinf. active responses	0.1	0.1	0.1	-0.2	-0.2	-0.2	0.4
Condit. Reinf. inactive responses	1.5	1.9	2.6	-1.3	-1.2	-1.6	1.3
Incentive salience index mean	0.0	0.0	0.0	0.0	-0.1	0.2	0.1
Condit. Reinf. lever presses	0.0	0.0	0.1	0.2	0.2	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.0	0.0	-0.3	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	-0.1	-0.5	0.3
Condit. Reinf. active responses	0.1	0.1	0.2	-0.2	-0.3	-0.5	0.4
Condit. Reinf. inactive responses	0.5	0.8	0.9	-0.8	-1.0	-0.8	0.9
Condit. Reinf. lever presses	0.3	0.5	1.0	-0.7	-0.5	-1.0	0.4
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	-0.3	-0.4	-0.6	0.5
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.0
Conditioned reinforcement - inactives	0.1	0.1	0.3	-0.5	-0.0	-0.6	-0.0
Conditioned locomotion	0.5	0.8	1.2	-0.9	-1.1	-0.6	0.9
Patch foraging indifference point 0 sec	0.1	0.4	0.4	-0.6	-0.6	-0.6	0.5
Patch foraging indifference point AUC	2.1	5.1	5.7	-2.2	-2.3	-2.1	2.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.3	0.3	0.2	-0.3
Delay disc. indifference point, 16s delay	0.6	0.8	1.1	0.6	1.0	1.0	-0.9
Delay disc. indifference point, 2s delay	4.3	4.9	5.2	-2.2	-2.3	-2.1	2.3
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	-0.2	-0.2	0.1	0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.3	-0.1	-0.4	-0.1
Delay disc. indifference point, 8s delay	0.6	1.0	1.3	0.9	1.0	1.1	-1.0
Indifference point function ln k	0.7	2.2	2.3	1.4	1.5	1.5	-1.5
Indifference point function log k	0.7	2.2	2.3	1.4	1.5	1.5	-1.5
Patch foraging total patch changes 0 sec	0.2	0.5	0.6	-0.8	-0.7	-0.8	0.6
Patch foraging total patch changes 12 sec	1.8	2.4	3.1	-1.5	-1.8	-1.0	1.7
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	-0.4	-0.4	-0.6	0.4
Patch foraging total patch changes 24 sec	0.8	2.6	3.1	-1.6	-1.8	-1.4	1.7
Patch foraging total patch changes 6 sec	1.7	2.9	3.0	-1.7	-1.7	-1.7	1.7
Patch foraging time to switch 0 sec	2.0	7.6	7.8	2.8	2.8	2.7	-2.7
Patch foraging water rate 0 sec	1.3	4.9	5.4	-2.2	-2.3	-2.0	2.3
Patch foraging water rate 12 sec	0.3	1.2	1.3	-1.1	-1.1	-1.1	1.1
Patch foraging water rate 18 sec	1.8	4.0	4.3	-1.9	-2.1	-2.0	2.0
Patch foraging water rate 24 sec	1.6	2.2	3.0	-1.4	-1.4	-1.7	1.4
Patch foraging water rate 6 sec	1.5	2.2	2.6	-1.6	-1.6	-1.3	1.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.8	-0.3	-0.1	-0.9	0.2
Distance traveled before self-admin	0.0	0.0	0.0	0.1	0.2	0.0	-0.2
Distance traveled after self-admin	2.3	4.0	6.1	-1.9	-1.9	-2.5	1.8
Extensor digitorum longus weight	10.7	42.8	46.1	6.8	6.5	6.7	-6.2
Bone: elastic displacement	0.2	0.3	0.4	0.6	0.6	0.3	-0.6
Bone: elastic work	0.4	0.5	0.9	0.9	0.8	0.1	-0.8
Bone: endosteal estimation	1.3	3.3	3.6	-1.9	-1.7	-1.9	1.7
Bone: endosteal perimeter	0.1	0.3	0.7	-0.5	-0.4	-0.8	0.3
Epididymis fat weight	0.0	0.1	0.2	-0.0	0.1	0.5	-0.2
Delta time in closed arm before/after self-admin	1.0	0.9	1.2	1.1	0.8	1.1	-0.8
Delta time in open arm before/after self-admin	0.5	0.6	0.9	-1.0	-0.7	-0.6	0.8
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	-0.0	0.4	0.3	-0.1
Delay discount exponential model param	0.1	0.1	0.2	0.4	0.3	0.2	-0.2
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.2	0.6	-0.0	-0.2
Active lever presses in extinction session 6	1.0	1.0	1.1	-1.0	-0.9	-1.0	1.0
Bone: final force	0.2	0.3	0.3	-0.6	-0.5	-0.5	0.5
Bone: final moment	0.2	0.3	0.4	-0.6	-0.6	-0.5	0.6
Food consumed during 24 hour testing period	1.4	2.8	3.7	-1.6	-1.6	-1.9	1.6
Glucose	1.0	1.6	1.9	-1.3	-1.4	-1.1	1.3
Heart weight	0.3	0.5	1.0	0.5	0.5	1.0	-0.7
Delay discount hyperbolic model param	0.2	0.3	0.4	0.6	0.5	0.5	-0.4
Intermittent access intake day 1-15 change	0.1	0.4	0.5	0.7	0.5	0.7	-0.6
Intermittent access intake escalation	0.2	0.8	1.0	1.0	0.7	1.0	-1.0
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.5	-0.3	-0.4	0.2
Intermitt. access day 1 inactive lever presses	0.2	2.6	3.6	-1.9	-1.4	-1.6	1.5
Intermitt. access day 15 inactive lever presses	0.8	4.2	5.0	-2.2	-2.0	-2.1	1.9
Intermitt. access escalation Index	0.6	1.8	2.3	1.4	1.5	1.1	-1.3
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.1	0.0	-0.2	-0.0
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.5	0.8	0.9	-1.0	-0.9	-1.0	0.8
Intermittent access total infusions	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.0
Intermittent access day 1 locomotion	0.3	0.5	0.6	-0.8	-0.8	-0.7	0.6
Intermittent access day 15 total locomotion	0.2	0.8	1.3	-0.9	-1.1	-0.5	0.9
Intermittent access total locomotion	0.0	0.0	0.2	-0.1	-0.4	0.0	0.1
Intermittent access standard deviation	0.1	0.5	0.8	-0.9	-0.6	-0.9	0.4
Left kidney weight	0.0	0.3	0.5	-0.6	-0.7	-0.3	0.5
Right kidney weight	0.1	1.0	1.7	-1.0	-1.3	-0.7	0.9
Cocaine induced anxiety	0.1	0.2	0.3	0.5	0.3	0.5	-0.5
Post-drug Anxiety	0.0	0.0	0.1	0.1	0.1	0.3	-0.1
Baseline Anxiety	0.1	0.2	0.4	-0.4	-0.2	-0.6	0.4
Tail length	0.3	1.8	2.2	-1.4	-1.3	-1.5	1.1
Length with tail	0.7	3.0	3.6	-1.7	-1.9	-1.7	1.5
Length without tail	0.4	2.1	2.8	-1.4	-1.7	-1.2	1.4
Times rat made contact with spout	0.1	0.1	0.1	-0.1	-0.2	-0.4	0.2
Lifetime Intake	0.2	0.3	0.5	0.5	0.6	0.2	-0.7
Liver weight, left	0.6	1.0	1.1	-1.0	-1.0	-1.0	1.0
Liver weight, right	1.5	2.7	2.8	-1.7	-1.7	-1.7	1.5
Locomotor activity	1.1	1.7	2.1	-1.3	-1.4	-1.2	1.3
Locomotor testing distance	0.2	0.4	0.5	-0.6	-0.7	-0.6	0.5
Locomotor testing rearing	0.0	0.1	0.2	-0.2	-0.2	-0.4	0.1
Locomotion in novel chamber	0.0	0.0	0.1	-0.3	-0.1	-0.0	0.0
Locomotion in novel chamber post-restriction	0.1	0.3	0.4	-0.6	-0.4	-0.6	0.4
Fecal boli incidents, locomotor time 1	1.1	3.0	4.0	1.6	2.0	1.3	-1.9
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.7	0.5	0.4	-0.5
Time >=10cm from walls, locomotor time 1	3.4	4.2	5.6	2.1	2.4	1.5	-2.1
Bouts of movement, locomotor time 1	0.9	1.2	1.3	1.0	1.1	1.1	-1.1
Total resting periods, locomotor time 1	0.7	0.8	0.9	0.9	0.9	0.9	-0.9
Rest time, locomotor task time 1	0.5	0.8	1.3	-0.7	-0.8	-1.2	0.8
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.3	0.3	0.5	-0.4
Vertical activity count, locomotor time 1	0.1	0.5	0.7	-0.8	-0.8	-0.2	0.8
Time >=10cm from walls, locomotor time 2	0.6	1.6	2.6	1.3	1.6	0.6	-1.4
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.2	-0.0	-0.2	0.0
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.0
Rest time, locomotor task time 2	0.3	0.5	0.8	-0.5	-0.7	-0.9	0.7
Distance moved, locomotor task time 2	0.5	0.7	1.1	0.8	0.6	1.0	-0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.3	-0.5	-0.6	-0.1	0.5
Light reinforcement 1	0.3	1.4	1.6	-1.2	-1.3	-1.1	1.1
Light reinforcement 2	0.1	0.1	0.2	0.3	0.5	0.2	-0.5
Bone: marrow area	1.3	3.1	3.5	-1.9	-1.7	-1.8	1.6
Bone: maximum diameter	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.2
Bone: maximum force	0.3	0.6	0.7	-0.8	-0.8	-0.8	0.7
Bone: maximum moment	0.4	0.8	0.9	-0.9	-0.9	-0.9	0.9
Mean time between licks in bursts	0.6	3.4	5.1	1.8	1.7	2.3	-1.5
Mean num. licks in bursts	0.2	0.7	1.0	-1.0	-0.8	-0.7	0.7
Cd content in liver	6.4	7.1	7.4	2.6	2.7	2.6	-2.7
Co content in liver	0.0	0.0	0.0	0.2	0.1	0.1	0.2
Cu content in liver	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.2
Fe content in liver	0.0	0.1	0.1	0.3	0.1	0.4	0.0
K content in liver	0.6	0.6	0.7	-0.8	-0.7	-0.6	0.8
Mg content in liver	0.2	0.2	0.3	-0.4	-0.4	-0.3	0.5
Mn content in liver	0.1	0.1	0.2	0.4	0.4	0.4	-0.3
Na content in liver	0.4	0.4	0.7	-0.6	-0.7	-0.8	0.5
Rb content in liver	0.9	1.0	1.5	1.1	0.9	1.2	-0.7
Se content in liver	0.2	0.3	0.4	-0.6	-0.6	-0.3	0.6
Sr content in liver	0.3	0.3	0.4	0.5	0.5	0.3	-0.7
Zn content in liver	0.2	0.2	0.4	0.5	0.5	0.6	-0.3
Bone: minimum diameter	7.2	13.8	15.4	-3.9	-3.7	-3.6	3.5
Time in familiar zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.3
Time in novel zone, hab. session 1	0.4	0.4	0.6	0.6	0.5	0.8	-0.6
Total zone transitions, hab. session 1	0.0	0.1	0.2	0.1	-0.1	-0.4	0.0
Total locomotion distance, hab. session 1	1.5	2.1	3.1	-1.3	-1.3	-1.8	1.3
Locomotion velocity, hab. session 1	1.0	1.4	2.4	-1.1	-1.0	-1.5	1.0
Time in familiar zone, hab. session 2	0.4	0.5	0.7	0.8	0.7	0.4	-0.8
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.5	-0.5	0.1	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	0.4	-0.1	-0.4
Total locomotion distance, hab. session 2	0.3	0.4	1.0	-0.6	-0.4	-1.0	0.3
Locomotion velocity, hab. session 2	0.3	0.4	1.0	-0.5	-0.4	-1.0	0.3
Novel to familiar place preference ratio	0.1	0.2	0.3	-0.3	-0.5	-0.2	0.6
Novelty place preference	0.0	0.0	0.1	0.0	-0.2	0.1	0.2
Time in novel zone, NPP test	0.1	0.1	0.3	-0.3	-0.5	-0.1	0.5
Total zone transitions, NPP test	0.1	0.1	0.2	0.4	0.3	0.0	-0.4
Total locomotion distance, NPP test	0.1	0.1	0.4	-0.1	-0.2	-0.6	0.1
Locomotion velocity, NPP test	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3
Intraocular pressure	0.4	0.7	0.8	0.9	0.8	0.8	-0.8
Delta distance traveled before/after self-admin	4.0	4.4	5.1	-1.9	-2.2	-2.3	2.1
Delta ambulatory time before/after self-admin	1.3	2.2	2.6	-1.3	-1.5	-1.6	1.5
Parametrial fat weight	1.7	4.1	4.5	-2.0	-2.1	-2.0	2.0
Pavlov. Cond. lever latency	1.6	2.0	2.4	1.5	1.6	1.1	-1.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.0	0.0	0.1
Pavlov. Cond. change in total contacts	0.4	0.4	0.5	-0.7	-0.7	-0.2	0.7
Pavlov. Cond. index score	0.6	0.8	1.0	-0.9	-1.0	-0.6	1.0
Pavlov. Cond. latency score	0.8	1.0	1.2	-1.0	-1.1	-0.7	1.1
Pavlov. Cond. lever contacts	1.5	1.8	2.1	-1.4	-1.5	-1.0	1.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.2	0.3	0.0	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	-0.7	-0.6	-0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.0	-0.9	-1.0	-0.6	1.0
Pavlov. Cond. response bias	0.5	0.6	0.8	-0.8	-0.8	-0.6	0.9
Pavlov. Cond. lever latency	0.6	0.8	1.1	-0.9	-1.0	-0.4	1.0
Pavlov. Cond. magazine entry latency	1.3	1.8	2.3	1.5	1.4	1.1	-1.3
Pavlov. Cond. change in total contacts	0.3	0.8	1.0	0.9	1.0	0.6	-1.0
Pavlov. Cond. index score	1.0	1.5	1.9	1.3	1.4	0.8	-1.4
Pavlov. Cond. latency score	1.2	2.0	2.4	1.5	1.6	1.0	-1.5
Pavlov. Cond. lever contacts	0.2	0.3	0.4	0.5	0.6	0.0	-0.7
Pavlov. Cond. magazine entry number	2.4	3.1	3.7	-1.9	-1.9	-1.4	1.8
Pavlov. Cond. intertrial magazine entries	1.1	2.3	2.5	-1.6	-1.6	-1.5	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.3	1.7	1.2	1.3	0.7	-1.2
Pavlov. Cond. response bias	0.7	1.0	1.3	1.1	1.2	0.5	-1.1
Time in closed arm before self-admin	0.8	1.4	2.0	-1.4	-1.2	-0.8	1.1
Time in closed arm after self-admin	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.1
Time in open arm before self-admin	0.1	0.1	0.4	0.6	0.1	0.2	-0.1
Time in open arm after self-admin	0.4	0.5	0.9	-0.6	-0.5	-0.9	0.6
Bone: periosteal estimation	0.9	2.1	2.5	-1.6	-1.4	-1.4	1.4
Bone: periosteal perimeter	0.2	0.3	0.5	-0.6	-0.5	-0.7	0.4
Bone: post-yield work	0.1	0.2	0.3	-0.5	-0.4	-0.3	0.4
Progressive ratio test 1 active lever presses	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.2
Progressive ratio test 1 breakpoint	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2
Progressive ratio test 1 inactive lever presses	0.8	2.2	2.8	-1.6	-1.3	-1.7	1.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.3	-0.4	-0.1	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	-0.3	-0.4	-0.1	0.2
Progressive ratio test 2 inactive lever presses	0.4	1.4	1.6	-1.3	-1.1	-1.2	1.0
Incentive Sensitization - Responses	0.1	0.3	0.4	0.3	0.5	0.6	-0.6
Incentive Sensitization - Breakpoint	0.1	0.2	0.3	0.3	0.4	0.6	-0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.0	0.0	-0.2	0.0
Progressive ratio	0.0	0.1	0.1	0.3	0.3	0.1	-0.4
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.6	0.2	0.3	-0.1
Seeking ratio, punishment vs. effort	0.3	0.7	1.1	-0.7	-1.0	-0.6	1.1
Retroperitoneal fat weight	0.2	1.1	1.7	-1.1	-1.3	-0.7	1.0
Reaction time number correct	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.3
Reaction time mean minus median	0.1	0.9	1.0	0.9	0.9	0.8	-1.0
Reaction time mean minus median AUC	0.1	0.5	0.7	0.6	0.6	0.9	-0.7
Reaction time num false alarms	0.2	0.4	0.5	-0.7	-0.7	-0.2	0.7
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.2	-0.2	0.1	0.2
Reaction time trials correct on left	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.3
Reaction time trials on left	0.0	0.0	0.1	0.0	0.2	-0.0	-0.3
Reaction time mean	0.7	1.6	2.1	1.1	1.4	1.2	-1.3
Reaction time mean AUC	0.5	1.3	1.7	0.9	1.3	1.1	-1.1
Median of all reaction times	0.9	1.4	1.9	1.0	1.4	1.2	-1.2
Reaction time omissions	0.8	1.3	1.5	1.1	1.1	1.2	-1.1
Reaction time false alarm rate	0.0	0.1	0.1	-0.2	-0.3	0.2	0.4
Reaction time premature initiation rate	0.3	0.5	0.8	-0.9	-0.5	-0.6	0.7
Reaction time premature initiations	0.2	0.5	1.0	-1.0	-0.5	-0.6	0.6
Std. dev. reaction times	0.2	0.8	0.9	0.7	1.0	0.9	-0.9
Reaction time trials completed	0.0	0.0	0.1	0.0	0.2	-0.0	-0.3
Reaction time trials AUC	0.0	0.0	0.1	0.1	0.2	0.1	-0.3
Run reversals in cocaine runway, females	3.3	3.7	4.3	-1.9	-2.1	-1.8	1.9
Run reversals in cocaine runway, males	0.0	0.1	0.1	0.2	0.1	0.4	0.0
Latency to leave start box in cocaine runway	1.1	1.5	2.6	-1.1	-1.0	-1.6	1.0
Latency to leave start box in cocaine runway, F	3.1	3.9	5.1	-2.0	-1.9	-2.3	1.8
Latency to leave start box in cocaine runway, M	0.1	0.0	0.1	0.3	0.2	-0.2	-0.1
Std. dev. time between licks in bursts	0.5	0.9	1.3	0.9	0.9	1.1	-0.7
Total sessions with >9 infusions	1.7	2.2	2.6	1.5	1.4	1.3	-1.6
Short access day 1 total inactive lever presses	0.1	0.3	0.7	-0.5	-0.2	-0.8	0.2
Short access day 10 total inactive lever presses	0.2	1.4	1.9	-1.4	-1.0	-1.3	1.0
Short access day 1 total infusions	0.0	0.1	0.2	-0.3	-0.3	-0.4	0.1
Short access day 10 total infusions	0.4	0.7	1.0	0.9	1.0	0.3	-0.9
Short access total infusions	0.9	1.3	1.7	1.1	1.3	0.7	-1.3
Short access day 1 locomotion	0.0	0.1	0.1	0.4	0.2	0.1	-0.3
Short access day 10 total locomotion	0.0	0.1	0.2	0.1	0.4	0.3	-0.4
Short access total locomotion	0.3	0.5	0.6	0.6	0.7	0.6	-0.8
One hour access (0.3 mA shock)	0.1	0.1	0.3	-0.1	-0.1	-0.5	-0.0
Compulsive drug intake	0.1	0.2	0.4	0.4	0.6	-0.4	-0.4
One hour access (shock baseline)	0.0	0.1	0.3	-0.3	-0.5	-0.1	0.3
Social response proportion	0.6	0.8	1.4	-0.8	-0.6	-1.2	0.8
Social responses	0.8	1.1	1.3	-1.0	-1.1	-0.9	1.1
Social time	0.2	0.3	0.5	-0.5	-0.5	-0.7	0.4
Soleus weight	0.5	1.5	1.9	1.1	1.2	1.1	-1.4
Bone: stiffness	1.2	2.3	2.7	-1.6	-1.6	-1.2	1.5
Tibialis anterior weight	4.2	14.5	16.5	3.8	3.7	4.1	-3.7
Time to tail flick, vehicle, before self-admin	2.3	2.9	3.3	-1.5	-1.8	-1.6	1.8
Time to tail flick, vehicle, after self-admin	0.7	1.4	1.8	-1.3	-1.1	-1.2	1.0
Time to tail flick, test, before self-admin	0.0	0.0	0.0	-0.1	-0.1	0.0	0.2
Time to tail flick, test, after self-admin	2.3	2.5	3.0	-1.7	-1.6	-1.4	1.5
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.3	-0.1	-0.0	0.0
Delta time to tail flick, test, before/after SA	0.7	0.9	1.2	-1.1	-1.0	-0.9	0.8
Tibia length	0.4	1.0	1.6	-1.3	-1.0	-0.7	1.0
Ambulatory time before self-admin	0.0	0.0	0.0	-0.0	0.1	-0.0	-0.1
Ambulatory time after self-admin	2.5	4.0	5.5	-1.9	-1.9	-2.3	1.8
Bone: tissue strength	1.1	1.1	1.3	-1.1	-1.0	-1.0	1.0
Total heroin consumption	1.5	1.8	2.3	-1.2	-1.5	-1.1	1.5
Bone: trabecular number	0.0	0.0	0.1	0.2	0.0	-0.0	-0.0
Bone: trabecular spacing	0.1	0.1	0.1	-0.3	-0.2	0.4	0.2
Bone: trabecular thickness	0.1	0.1	0.3	-0.2	-0.2	-0.5	0.1
Bone: trabecular tissue density	0.3	0.5	0.9	0.7	0.7	1.0	-0.6
Water consumed over 24 hours	1.0	1.9	2.4	-1.2	-1.4	-1.6	1.3
Number of responses in last shaping day	0.3	0.3	0.4	0.6	0.6	0.5	-0.6