Hub : Genes

Sult1d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Sult1d1 0.13 0.06 0.0e+00 0.14 0.14 0.16 0.16 1.2e-15 7.6e-15 6.2e-17 2.0e-17
2 Brain gene expression Sult1d1 0.11 0.07 2.1e-10 0.12 0.12 0.12 0.12 5.0e-11 3.7e-11 7.7e-11 2.4e-11
3 Liver alternative TSS XM_039092368.1 0.07 0.05 2.5e-05 0.02 0.02 0.02 0.02 3.1e-03 3.0e-03 2.1e-03 3.2e-03
4 LHb gene expression Sult1d1 0.9 0.07 8.7e-04 0.04 0.1 0.05 0.09 4.1e-02 2.4e-03 3.1e-02 4.6e-03
5 PL gene expression Sult1d1 0.15 0.12 2.7e-06 0.04 0.03 0.05 0.06 9.4e-05 1.7e-04 2.3e-06 1.1e-06
6 BLA gene expression Sult1d1 0.17 0.09 3.9e-10 0.14 0.18 0.17 0.16 8.4e-08 4.9e-10 2.6e-09 6.1e-09
7 Liver alternative TSS XM_039092368.1 0.07 0.05 1.3e-06 0.04 0.05 0.04 0.03 4.2e-05 7.8e-06 3.2e-05 2.9e-04
8 NAcc gene expression Sult1d1 0.08 0.05 1.0e-08 0.07 0.07 0.06 0.06 3.8e-08 3.0e-08 7.7e-08 8.3e-08
9 Liver isoform ratio XM_039092368.1 0.08 0.07 2.0e-04 0.02 0.03 0.02 0.01 6.1e-03 7.4e-04 2.1e-03 1.6e-02
10 Brain mRNA stability Sult1d1 0.07 0.05 5.5e-07 0.07 0.07 0.06 0.07 7.2e-07 2.6e-07 1.1e-06 8.9e-07
11 NAcc mRNA stability Sult1d1 0.04 0.03 3.4e-05 0.04 0.03 0.04 0.04 2.9e-05 4.1e-04 3.9e-05 1.9e-05
12 Liver gene expression Sult1d1 0.19 0.1 3.8e-06 0.02 0.03 0.02 0.02 1.1e-03 2.5e-04 5.3e-03 9.5e-04
13 LHb mRNA stability Sult1d1 0.23 0.17 1.3e-03 0.1 0.12 0.11 0.13 1.9e-03 7.1e-04 1.3e-03 6.6e-04
14 OFC alternative polyA XM_039092368.1 0.7 0.15 8.7e-03 0.01 0.03 0.09 0.07 1.7e-01 7.4e-02 4.5e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.40.7-0.9-0.90.6-0.60.1-0.8-0.7-0.5-0.4-0.5-0.8-0.1-0.6-0.6
Area under the delay curve0.10.10.9-0.00.20.9-0.10.0-0.20.0-0.40.1-0.30.3-0.3-0.3-0.1
BMI with tail1.34.27.8-2.3-2.31.8-2.1-1.8-2.0-1.9-2.8-1.6-2.7-2.11.4-2.0-0.6
BMI without tail0.10.20.80.40.0-0.20.20.90.50.2-0.60.2-0.8-0.10.3-0.3-0.8
Body weight0.10.51.7-0.3-0.50.6-0.40.4-0.3-0.6-1.2-0.6-1.3-0.50.8-0.7-1.0
Weight adjusted by age1.31.52.3-1.2-0.91.5-1.3-1.1-1.4-1.5-0.9-1.5-0.8-1.21.2-1.4-0.9
Bone surface0.10.10.5-0.2-0.60.4-0.20.4-0.4-0.50.2-0.30.2-0.3-0.0-0.4-0.7
Bone volume0.10.10.50.30.1-0.20.40.70.20.20.50.40.50.2-0.60.1-0.1
Breakpoint value in progressive ratio session0.20.20.50.60.5-0.50.40.40.40.50.20.60.20.5-0.70.40.7
Number of licking bursts0.30.31.3-0.5-0.70.3-0.30.9-0.4-0.4-0.3-0.1-0.3-0.6-0.2-0.5-1.1
Context. condit. distance diff. score0.40.41.70.50.7-0.10.2-1.30.10.11.1-0.21.30.40.30.30.5
Locomotion velocity, session 10.60.61.9-1.0-0.60.6-0.8-0.1-0.8-0.7-1.4-0.4-1.4-0.80.1-0.9-0.3
Locomotion distance, session 10.20.30.60.40.5-0.50.50.20.40.50.60.60.70.5-0.70.40.5
Locomotion velocity, session 20.20.20.90.10.7-0.20.30.10.00.20.30.30.50.5-0.60.40.9
Locomotion distance, session 20.10.20.40.40.3-0.40.40.50.30.40.40.50.40.4-0.70.30.5
Locomotion velocity, session 30.60.70.90.90.9-1.00.80.60.90.91.00.70.90.9-0.50.60.8
Locomotion distance, session 30.00.00.1-0.10.1-0.2-0.0-0.2-0.10.10.20.10.2-0.1-0.3-0.40.0
Stereotopy head waving bouts, day 30.40.51.1-0.5-0.60.8-0.7-0.1-0.6-0.7-1.0-0.7-1.0-0.60.8-0.7-0.8
Stereotopy head waving duration, day 30.00.00.20.1-0.20.3-0.20.2-0.1-0.2-0.4-0.2-0.4-0.00.30.00.0
Locomotion velocity, session 72.32.53.21.81.6-1.81.71.71.71.71.41.71.31.6-1.51.30.9
Locomotion distance, session 71.21.62.71.21.2-1.41.30.81.11.41.31.51.41.1-1.60.91.2
Stereotopy head waving bouts, day 70.20.30.4-0.5-0.40.6-0.5-0.4-0.6-0.6-0.4-0.6-0.4-0.40.6-0.4-0.6
Stereotopy head waving duration, day 70.20.30.8-0.6-0.40.5-0.6-0.4-0.5-0.5-0.9-0.5-0.9-0.40.5-0.4-0.1
Locomotion velocity, session 80.30.31.9-0.20.30.1-0.2-1.3-0.4-0.10.2-0.10.40.3-0.20.31.4
Locomotion distance, session 80.71.03.21.01.1-0.70.8-0.60.60.71.60.61.81.0-0.70.91.1
Degree of sensitization distance1.11.12.21.51.1-1.01.20.61.21.11.11.01.11.1-0.81.10.7
Degree of sensitization stereotypy0.00.10.1-0.4-0.30.2-0.2-0.3-0.2-0.2-0.0-0.2-0.0-0.30.1-0.1-0.4
Conditioned locomotion0.60.72.3-1.1-0.50.7-0.8-1.5-1.0-0.6-0.6-0.5-0.4-0.90.0-1.10.2
Cocaine response after cond. corrected0.60.71.10.70.7-0.90.90.80.80.90.91.00.90.7-1.00.70.6
Cocaine response after cond. not corrected0.60.61.10.70.6-0.80.80.90.70.81.00.91.00.7-0.90.70.2
Cocaine response before conditioning0.20.21.0-0.3-0.50.4-0.30.1-0.3-0.5-0.0-0.5-0.1-0.30.5-0.3-1.0
Saline control response0.70.91.11.01.1-0.91.00.61.01.01.00.91.01.1-0.71.00.6
Bone: connectivity density0.50.82.1-1.3-1.40.8-0.90.0-1.1-1.0-1.0-0.6-0.9-1.10.1-0.7-0.7
Bone: cortical apparent density0.30.41.0-0.20.0-0.60.20.70.30.5-0.70.7-0.80.3-0.70.71.0
Bone: cortical area0.30.51.71.30.3-0.60.81.11.10.70.50.40.30.90.20.7-0.2
Bone: cortical porosity1.92.14.0-2.0-1.41.6-1.6-1.2-1.9-1.7-1.2-1.4-1.1-1.60.7-1.4-0.9
Bone: cortical porosity2.93.24.3-2.1-1.62.0-1.9-1.4-2.0-2.0-1.7-1.8-1.6-1.91.4-1.8-1.5
Bone: cortical thickness0.40.61.3-0.4-1.10.7-0.6-0.4-0.4-0.7-0.8-0.8-0.9-0.61.1-0.6-0.9
Bone: cortical thickness0.20.20.60.40.3-0.20.30.60.30.20.80.10.70.2-0.10.3-0.6
Bone: cortical tissue density0.30.30.9-0.4-0.0-0.50.10.60.20.4-0.80.6-0.90.2-0.70.61.0
Condit. Reinf. active minus inactive responses0.70.81.3-0.8-0.80.8-0.8-0.3-0.7-0.8-1.0-0.9-1.1-0.91.0-1.0-1.2
Condit. Reinf. active-inactive response ratio3.33.55.5-1.7-1.92.0-1.9-1.4-1.7-2.0-1.7-2.2-1.8-1.82.3-1.8-2.0
Condit. Reinf. active responses0.10.10.50.1-0.1-0.20.20.70.20.20.00.3-0.0-0.1-0.3-0.0-0.2
Condit. Reinf. inactive responses2.32.74.21.51.4-1.81.71.91.61.81.62.01.61.3-2.01.51.1
Incentive salience index mean0.10.10.2-0.3-0.30.2-0.20.0-0.2-0.2-0.4-0.2-0.4-0.30.3-0.4-0.4
Condit. Reinf. lever presses0.00.00.2-0.1-0.2-0.1-0.00.0-0.10.10.10.20.1-0.0-0.50.00.5
Condit. Reinf. active minus inactive responses0.10.20.80.1-0.1-0.40.20.20.10.30.10.60.20.2-0.90.30.9
Condit. Reinf. active-inactive response ratio0.20.20.50.2-0.3-0.50.40.60.40.50.20.60.20.1-0.70.20.1
Condit. Reinf. active responses0.20.20.90.30.2-0.40.30.20.10.40.30.60.50.4-0.90.51.0
Condit. Reinf. inactive responses0.40.51.10.71.0-0.50.60.00.30.50.80.61.00.8-0.80.91.1
Condit. Reinf. lever presses0.30.41.30.70.1-0.70.70.40.70.61.10.51.10.5-0.40.60.1
Condit. Reinf. lever reinforcers received0.20.31.10.30.2-0.40.3-0.10.10.40.50.50.70.4-0.90.51.1
Conditioned reinforcement - actives0.20.20.8-0.30.30.5-0.3-0.9-0.4-0.4-0.0-0.50.1-0.30.5-0.8-0.5
Conditioned reinforcement - inactives1.01.21.91.01.4-1.21.10.51.11.21.41.01.41.1-0.90.90.6
Conditioned locomotion0.10.10.30.10.40.10.20.3-0.0-0.10.3-0.00.30.2-0.0-0.2-0.5
Patch foraging indifference point 0 sec0.40.72.10.50.4-0.90.70.40.60.80.60.90.60.9-1.01.01.5
Patch foraging indifference point AUC2.73.14.21.92.0-2.01.91.91.92.01.42.01.31.5-1.81.30.9
Delay disc. indifference point, 0s delay0.10.10.3-0.4-0.00.4-0.30.3-0.4-0.2-0.60.1-0.6-0.2-0.4-0.40.1
Delay disc. indifference point, 16s delay0.70.72.2-0.5-0.41.5-0.7-0.5-0.6-0.5-1.2-0.5-1.2-0.60.6-1.0-0.9
Delay disc. indifference point, 2s delay3.03.34.61.82.1-1.71.91.71.61.81.52.01.62.1-2.21.61.7
Delay disc. indifference point, 24s delay0.20.21.3-0.00.11.1-0.3-0.6-0.4-0.4-0.4-0.5-0.30.10.5-0.5-0.4
Delay disc. indifference point, 4s delay0.40.51.20.40.70.20.61.10.50.70.11.00.00.9-1.10.50.6
Delay disc. indifference point, 8s delay1.41.53.3-1.1-1.01.8-1.2-0.9-1.2-1.1-1.4-1.0-1.4-1.10.8-1.4-1.0
Indifference point function ln k0.91.32.8-0.9-1.01.3-1.2-1.2-1.1-1.3-0.8-1.6-0.8-0.81.7-0.9-1.1
Indifference point function log k0.91.32.8-0.9-1.01.3-1.2-1.2-1.1-1.3-0.8-1.6-0.8-0.81.7-0.9-1.1
Patch foraging total patch changes 0 sec0.40.72.00.50.5-0.90.70.40.70.80.60.90.61.0-1.01.01.4
Patch foraging total patch changes 12 sec0.30.40.70.90.7-0.80.80.40.80.90.20.80.10.5-0.60.60.5
Patch foraging total patch changes 18 sec0.20.20.80.10.4-0.60.30.70.30.50.10.70.10.2-0.90.20.2
Patch foraging total patch changes 24 sec0.91.01.51.11.2-1.11.00.30.91.21.01.21.00.9-1.20.71.0
Patch foraging total patch changes 6 sec1.32.02.71.51.3-1.61.51.31.61.61.11.61.11.5-1.41.31.0
Patch foraging time to switch 0 sec3.45.36.5-2.5-2.32.5-2.5-2.3-2.4-2.4-2.6-2.4-2.5-2.22.1-2.0-1.1
Patch foraging water rate 0 sec1.82.95.51.91.7-1.71.92.31.81.71.71.71.61.6-1.41.50.2
Patch foraging water rate 12 sec0.40.71.40.71.0-0.70.90.80.70.71.20.61.20.9-0.60.7-0.1
Patch foraging water rate 18 sec2.02.64.11.71.5-1.51.71.81.61.52.01.42.01.8-1.31.70.7
Patch foraging water rate 24 sec1.11.53.51.21.2-1.01.31.41.11.01.91.01.91.1-1.01.00.0
Patch foraging water rate 6 sec0.60.91.71.30.9-0.91.11.31.31.01.10.80.91.0-0.30.8-0.3
Seeking ratio, delayed vs. immediate footshock1.01.11.91.30.7-1.11.00.81.11.11.41.11.30.8-1.01.00.7
Distance traveled before self-admin0.40.40.60.80.7-0.70.80.30.80.70.70.60.70.6-0.30.60.1
Distance traveled after self-admin2.73.05.42.01.9-1.71.81.21.61.72.31.62.31.7-1.51.61.0
Extensor digitorum longus weight10.842.354.5-7.4-7.36.7-7.0-6.2-7.0-6.8-6.5-6.3-6.3-6.85.2-6.7-4.2
Bone: elastic displacement0.60.71.3-1.1-1.00.8-0.9-0.9-1.1-0.9-0.2-0.8-0.1-1.00.3-0.8-0.3
Bone: elastic work0.40.51.5-1.2-1.20.6-0.7-0.4-1.0-0.70.0-0.40.1-0.8-0.3-0.5-0.1
Bone: endosteal estimation1.83.96.22.42.5-1.82.11.72.01.92.21.72.22.3-1.42.01.4
Bone: endosteal perimeter0.40.81.51.20.6-0.71.01.20.90.71.10.61.01.0-0.50.80.2
Epididymis fat weight0.10.10.60.20.30.3-0.10.2-0.2-0.2-0.8-0.1-0.80.00.1-0.40.1
Delta time in closed arm before/after self-admin1.61.53.2-1.1-0.71.3-1.2-0.9-0.9-1.2-1.2-1.4-1.3-1.11.6-1.2-1.8
Delta time in open arm before/after self-admin1.71.62.71.21.2-1.41.21.21.11.31.01.41.01.1-1.51.31.6
Diff in mean of infusions in LGA sessions0.10.11.00.1-0.20.2-0.2-1.0-0.1-0.10.0-0.40.0-0.30.6-0.20.2
Delay discount exponential model param0.10.10.6-0.1-0.3-0.8-0.1-0.1-0.0-0.20.2-0.30.2-0.50.40.1-0.1
Extinction: sum of active levers before priming0.50.50.90.60.8-0.70.60.60.50.71.00.81.00.5-1.00.60.7
Active lever presses in extinction session 60.80.81.91.10.9-0.80.91.40.80.80.80.90.80.5-1.00.70.5
Bone: final force0.20.31.30.90.2-0.20.51.10.60.30.20.10.10.60.20.3-0.4
Bone: final moment0.20.31.70.80.3-0.20.51.30.60.30.30.10.10.60.30.3-0.6
Food consumed during 24 hour testing period2.12.55.11.31.0-1.61.51.01.31.62.01.92.11.0-2.31.11.8
Glucose0.91.42.21.50.9-1.31.30.91.41.31.31.11.31.2-0.91.40.8
Heart weight0.60.92.6-0.2-0.51.1-0.7-0.8-0.5-0.9-0.8-1.2-0.8-0.71.6-0.6-1.4
Delay discount hyperbolic model param0.20.20.7-0.4-0.6-0.4-0.4-0.4-0.3-0.5-0.1-0.6-0.1-0.80.7-0.2-0.5
Intermittent access intake day 1-15 change1.91.93.8-1.0-1.11.5-1.2-1.3-1.3-1.5-0.7-1.5-0.7-1.51.4-1.8-1.9
Intermittent access intake escalation0.80.81.7-0.8-0.61.0-0.8-1.1-1.1-1.0-0.4-0.9-0.2-1.20.6-1.3-1.0
Intermittent access intake escalation 20.20.21.10.51.00.00.30.30.10.10.5-0.00.50.00.1-0.3-0.8
Intermitt. access day 1 inactive lever presses1.41.58.00.91.3-1.10.8-1.10.71.21.01.11.20.8-1.20.82.8
Intermitt. access day 15 inactive lever presses1.41.62.11.31.3-1.31.30.81.21.31.41.31.41.4-1.31.01.2
Intermitt. access escalation Index1.51.32.3-1.3-1.51.1-1.2-0.9-1.2-1.2-0.9-1.1-0.9-1.50.8-1.2-0.9
Intermittent access day 1 total infusions0.00.00.10.10.4-0.20.10.20.10.10.40.00.30.20.10.1-0.3
Intermittent access day 15 total infusions0.10.10.80.10.30.20.0-0.3-0.1-0.10.5-0.20.5-0.20.3-0.5-0.9
Intermittent access terminal intake (last 3 days)0.40.41.20.81.0-0.30.60.40.50.30.90.10.90.30.2-0.1-1.1
Intermittent access total infusions0.10.11.10.20.3-0.10.20.20.20.10.5-0.10.40.00.3-0.2-1.1
Intermittent access day 1 locomotion0.10.10.40.10.6-0.10.1-0.10.10.20.20.10.30.5-0.10.30.3
Intermittent access day 15 total locomotion0.20.21.20.41.1-0.00.30.20.20.10.5-0.10.40.50.4-0.0-0.8
Intermittent access total locomotion0.10.10.8-0.20.40.3-0.10.1-0.2-0.3-0.1-0.3-0.20.10.4-0.3-0.9
Intermittent access standard deviation0.10.10.30.30.3-0.20.4-0.00.20.20.50.20.60.3-0.20.1-0.0
Left kidney weight0.51.33.01.71.5-0.61.11.41.30.71.30.31.10.90.40.5-1.6
Right kidney weight0.61.63.92.01.4-1.01.51.91.71.11.00.80.71.30.01.0-0.9
Cocaine induced anxiety0.10.10.2-0.1-0.50.3-0.30.2-0.2-0.3-0.4-0.3-0.4-0.30.3-0.3-0.4
Post-drug Anxiety0.10.10.30.50.2-0.20.20.60.50.3-0.20.1-0.40.30.40.2-0.3
Baseline Anxiety0.10.10.30.20.6-0.20.2-0.10.20.20.50.10.50.40.00.3-0.1
Tail length0.30.83.41.11.0-0.50.81.80.90.50.90.40.70.5-0.00.1-1.5
Length with tail0.72.75.42.32.0-1.31.92.31.91.41.71.11.61.8-0.51.4-0.5
Length without tail0.30.71.41.01.0-0.70.80.40.80.70.60.60.71.2-0.51.11.2
Times rat made contact with spout0.20.30.90.30.5-0.50.51.00.40.50.20.70.20.3-0.80.30.4
Lifetime Intake0.10.10.9-0.2-0.10.1-0.10.0-0.1-0.10.2-0.20.1-0.20.2-0.4-1.0
Liver weight, left2.33.78.71.41.5-2.11.82.01.52.01.22.51.21.7-3.01.92.4
Liver weight, right2.94.88.91.91.8-2.42.12.21.92.31.72.61.72.1-3.02.22.6
Locomotor activity0.40.61.50.91.1-0.50.90.90.50.51.10.51.20.9-0.60.50.3
Locomotor testing distance0.10.21.40.50.5-0.10.4-0.10.10.11.1-0.11.20.4-0.10.10.1
Locomotor testing rearing0.10.10.60.30.00.10.1-0.2-0.0-0.20.7-0.30.8-0.10.4-0.2-0.6
Locomotion in novel chamber0.00.00.10.1-0.3-0.30.20.40.30.20.00.2-0.0-0.1-0.0-0.00.0
Locomotion in novel chamber post-restriction1.01.33.31.51.0-1.21.21.81.51.20.81.00.61.2-0.51.0-0.4
Fecal boli incidents, locomotor time 11.51.65.1-1.1-1.31.3-1.1-0.4-1.0-1.3-0.6-1.5-0.8-1.21.7-1.1-2.3
Change in fecal boli incidents, locomotor task0.10.10.5-0.4-0.20.4-0.3-0.2-0.5-0.2-0.20.1-0.1-0.3-0.6-0.20.7
Time >=10cm from walls, locomotor time 12.02.05.8-1.6-1.42.4-1.4-0.6-1.4-1.3-1.0-1.2-1.0-1.50.9-1.4-1.8
Bouts of movement, locomotor time 11.11.23.5-0.7-1.30.9-1.0-0.4-0.5-1.0-1.0-1.3-1.2-1.01.9-0.8-1.7
Total resting periods, locomotor time 10.80.92.4-0.6-1.10.7-0.8-0.1-0.4-0.8-0.8-1.1-1.0-0.81.5-0.7-1.5
Rest time, locomotor task time 10.60.62.10.80.3-0.30.81.40.80.51.40.31.20.50.00.7-0.6
Distance moved, locomotor task time 10.30.30.8-0.7-0.40.4-0.4-0.8-0.6-0.3-0.70.0-0.5-0.4-0.5-0.50.9
Vertical activity count, locomotor time 10.40.41.00.40.6-0.40.60.50.60.8-0.41.0-0.40.4-1.00.20.8
Time >=10cm from walls, locomotor time 20.50.52.7-1.0-0.81.6-0.6-0.3-0.9-0.6-0.0-0.30.0-0.7-0.3-0.7-0.6
Bouts of movement, locomotor time 20.10.10.50.30.6-0.00.30.40.30.30.30.20.30.7-0.20.50.0
Total resting periods, locomotor time 20.10.10.30.30.5-0.10.20.50.20.20.20.20.20.5-0.20.4-0.1
Rest time, locomotor task time 20.40.51.70.80.6-0.50.50.30.40.41.30.21.30.5-0.30.70.4
Distance moved, locomotor task time 21.41.63.1-1.6-1.81.1-1.2-1.0-1.3-1.2-1.6-0.8-1.5-1.50.4-1.3-0.0
Vertical activity count, locomotor time 20.10.20.5-0.1-0.5-0.10.10.70.20.2-0.60.5-0.7-0.2-0.5-0.1-0.1
Light reinforcement 10.51.01.91.40.9-1.11.11.01.21.11.01.00.91.0-0.80.70.3
Light reinforcement 20.00.00.10.1-0.10.0-0.10.2-0.1-0.1-0.1-0.1-0.2-0.20.1-0.1-0.4
Bone: marrow area1.73.65.92.32.4-1.72.01.61.91.82.11.62.12.2-1.31.91.4
Bone: maximum diameter0.10.20.80.8-0.0-0.00.30.90.60.1-0.2-0.1-0.40.30.70.1-0.5
Bone: maximum force0.40.61.91.20.5-0.50.91.41.00.60.80.40.61.0-0.00.8-0.2
Bone: maximum moment0.50.82.61.30.6-0.61.01.61.10.70.90.50.71.1-0.10.9-0.4
Mean time between licks in bursts4.46.29.8-2.1-2.42.6-2.5-1.9-2.1-2.5-2.6-2.8-2.7-2.33.1-2.2-2.7
Mean num. licks in bursts0.81.02.31.01.5-1.00.90.11.11.10.70.90.71.1-0.60.81.5
Cd content in liver1.82.03.0-1.4-1.71.4-1.5-1.0-1.2-1.4-1.4-1.6-1.5-1.41.7-1.2-1.3
Co content in liver0.10.10.80.40.1-0.20.30.90.40.10.20.10.10.40.10.6-0.2
Cu content in liver0.50.61.21.10.7-0.70.80.61.00.80.60.70.61.0-0.31.10.7
Fe content in liver0.40.51.6-0.8-0.50.7-0.60.3-0.8-0.7-1.3-0.4-1.2-0.40.2-0.3-0.4
K content in liver1.61.63.61.01.3-1.31.20.81.11.40.41.50.51.4-1.51.31.9
Mg content in liver1.41.42.11.21.2-1.31.21.21.31.40.41.40.31.3-1.21.11.3
Mn content in liver0.10.10.50.10.10.3-0.1-0.7-0.1-0.2-0.3-0.3-0.2-0.10.5-0.30.2
Na content in liver1.11.23.30.91.0-1.21.11.81.01.20.41.40.31.0-1.50.90.6
Rb content in liver0.60.81.6-0.7-0.71.0-0.8-0.3-0.7-0.9-1.2-0.9-1.3-0.91.0-1.0-0.7
Se content in liver0.10.10.30.60.3-0.30.3-0.30.50.40.10.10.10.40.20.20.5
Sr content in liver0.60.62.2-0.0-0.40.7-0.5-0.7-0.3-0.70.1-1.10.0-0.61.5-0.8-1.4
Zn content in liver1.01.14.00.60.6-1.00.80.10.71.10.81.31.00.8-1.61.12.0
Bone: minimum diameter5.810.918.34.33.4-3.23.63.63.83.33.32.93.03.8-1.93.61.5
Time in familiar zone, hab. session 10.40.42.40.10.2-0.30.2-0.5-0.00.30.60.50.80.3-0.90.51.5
Time in novel zone, hab. session 10.80.83.1-0.4-0.40.5-0.50.4-0.2-0.5-1.1-0.6-1.4-0.71.1-1.0-1.8
Total zone transitions, hab. session 10.30.41.50.2-0.0-0.60.60.90.40.60.60.90.60.3-1.20.40.2
Total locomotion distance, hab. session 12.02.94.41.61.4-1.71.61.21.31.62.01.72.11.7-2.01.81.7
Locomotion velocity, hab. session 11.72.44.21.41.3-1.51.51.01.21.41.91.52.01.5-1.81.71.5
Time in familiar zone, hab. session 20.10.10.7-0.8-0.50.1-0.4-0.3-0.5-0.2-0.1-0.0-0.1-0.3-0.4-0.20.5
Time in novel zone, hab. session 20.30.31.40.80.30.20.20.30.50.0-0.5-0.4-0.70.01.2-0.3-1.1
Total zone transitions, hab. session 20.10.21.00.2-0.2-0.10.20.70.20.00.5-0.10.4-0.00.2-0.2-1.0
Total locomotion distance, hab. session 20.60.81.81.10.7-0.90.91.11.00.81.30.61.20.9-0.40.9-0.1
Locomotion velocity, hab. session 20.60.91.91.00.7-0.90.91.00.80.81.40.71.31.0-0.70.90.1
Novel to familiar place preference ratio0.20.21.00.40.2-0.40.41.00.50.4-0.30.5-0.40.3-0.40.40.2
Novelty place preference0.20.20.90.2-0.0-0.20.11.00.30.2-0.60.3-0.80.1-0.10.1-0.0
Time in novel zone, NPP test0.30.31.40.40.2-0.50.41.20.60.4-0.50.5-0.60.3-0.30.30.1
Total zone transitions, NPP test0.10.10.40.0-0.1-0.30.20.60.10.20.10.40.1-0.1-0.6-0.1-0.2
Total locomotion distance, NPP test0.20.30.90.30.2-0.50.50.60.30.40.90.50.90.4-0.80.50.1
Locomotion velocity, NPP test0.10.10.4-0.1-0.2-0.20.10.2-0.10.00.60.20.60.0-0.50.2-0.1
Intraocular pressure0.71.02.1-1.0-1.21.0-0.80.1-0.8-1.0-1.1-1.0-1.2-0.91.0-0.7-1.5
Delta distance traveled before/after self-admin0.40.51.00.60.7-0.60.60.60.30.50.80.70.90.6-1.00.61.0
Delta ambulatory time before/after self-admin0.10.20.40.30.4-0.30.30.30.10.20.50.30.60.3-0.60.30.7
Parametrial fat weight1.83.56.21.61.7-2.01.92.51.71.91.22.11.12.1-2.22.21.8
Pavlov. Cond. lever latency0.81.02.1-1.5-1.21.0-1.1-0.7-1.2-1.2-0.7-1.0-0.7-1.00.7-0.8-0.4
Pavlov. Cond. magazine entry latency0.10.10.40.0-0.1-0.20.1-0.3-0.10.20.40.30.50.0-0.6-0.00.6
Pavlov. Cond. change in total contacts0.10.10.50.70.4-0.20.3-0.20.50.30.10.10.10.30.30.2-0.1
Pavlov. Cond. index score0.20.30.50.70.6-0.60.50.10.50.70.30.70.40.4-0.70.30.6
Pavlov. Cond. latency score0.30.40.80.90.8-0.70.70.20.70.80.40.80.50.5-0.70.30.5
Pavlov. Cond. lever contacts0.91.12.41.51.3-1.11.20.81.31.20.81.00.81.0-0.60.80.3
Pavlov. Cond. magazine entry number0.10.10.30.10.1-0.20.20.40.30.20.30.20.20.3-0.10.50.3
Pavlov. Cond. intertrial magazine entries0.40.51.31.10.8-0.60.81.01.00.70.20.60.10.6-0.20.5-0.1
Pavlov. Cond. lever-magazine prob. diff.0.30.40.80.70.6-0.70.60.10.50.70.40.80.50.6-0.90.50.9
Pavlov. Cond. response bias0.40.40.70.70.7-0.70.70.40.60.70.50.80.60.6-0.90.50.7
Pavlov. Cond. lever latency0.10.20.30.40.5-0.50.40.40.50.5-0.20.6-0.20.3-0.50.40.3
Pavlov. Cond. magazine entry latency0.91.01.7-1.2-1.31.1-1.1-0.7-1.1-1.2-0.5-1.1-0.5-1.01.0-1.0-0.9
Pavlov. Cond. change in total contacts0.50.60.9-0.8-0.90.9-0.8-0.9-0.9-0.9-0.1-1.0-0.1-0.80.8-0.9-0.7
Pavlov. Cond. index score0.70.91.3-1.1-1.11.1-1.0-0.8-1.1-1.1-0.2-1.1-0.1-0.90.9-0.9-0.8
Pavlov. Cond. latency score1.11.42.0-1.2-1.31.3-1.2-1.2-1.3-1.4-0.4-1.4-0.3-1.21.2-1.3-1.1
Pavlov. Cond. lever contacts0.10.10.3-0.3-0.50.3-0.2-0.3-0.4-0.40.4-0.40.5-0.30.1-0.2-0.3
Pavlov. Cond. magazine entry number1.51.82.71.61.6-1.61.41.01.61.60.71.50.71.3-1.21.31.2
Pavlov. Cond. intertrial magazine entries1.72.33.31.71.3-1.71.61.31.61.70.91.70.91.5-1.61.81.5
Pavlov. Cond. lever-magazine prob. diff.0.60.71.1-1.0-1.11.0-0.9-0.8-1.1-1.0-0.1-1.0-0.1-0.80.7-0.9-0.5
Pavlov. Cond. response bias0.50.71.2-1.1-1.10.9-0.9-0.7-1.1-1.0-0.1-0.9-0.0-0.90.5-0.8-0.6
Time in closed arm before self-admin0.91.02.11.41.0-0.91.00.31.00.90.90.71.01.2-0.41.11.4
Time in closed arm after self-admin0.60.62.90.00.10.7-0.4-1.3-0.2-0.6-0.1-1.1-0.1-0.01.7-0.3-1.0
Time in open arm before self-admin1.21.31.9-1.3-1.11.4-1.1-1.2-1.4-1.4-0.7-1.2-0.6-1.20.8-1.1-1.0
Time in open arm after self-admin1.51.74.80.70.9-1.41.11.40.91.30.61.70.70.8-2.21.22.0
Bone: periosteal estimation0.91.94.32.11.5-1.11.51.51.61.31.41.01.31.7-0.41.40.5
Bone: periosteal perimeter0.40.71.71.30.4-0.81.01.31.00.81.00.70.80.9-0.30.70.0
Bone: post-yield work0.30.40.90.80.9-0.50.71.00.70.50.30.40.30.9-0.10.8-0.1
Progressive ratio test 1 active lever presses0.30.32.50.20.50.3-0.00.50.1-0.20.0-0.5-0.10.00.9-0.3-1.6
Progressive ratio test 1 breakpoint0.30.32.7-0.00.20.4-0.20.3-0.1-0.4-0.1-0.6-0.2-0.20.9-0.5-1.6
Progressive ratio test 1 inactive lever presses2.42.66.31.31.6-1.81.50.21.41.81.51.81.61.3-2.01.42.5
Progressive ratio test 2 active lever presses0.10.20.70.40.8-0.20.30.00.40.20.3-0.00.20.40.4-0.1-0.7
Progressive ratio test 2 breakpoint0.10.20.70.40.5-0.00.2-0.10.40.10.1-0.20.00.40.7-0.2-0.8
Progressive ratio test 2 inactive lever presses0.91.01.91.11.4-1.01.10.51.11.11.30.91.30.9-0.60.60.4
Incentive Sensitization - Responses0.10.10.50.10.30.2-0.1-0.7-0.0-0.1-0.2-0.3-0.20.10.6-0.4-0.2
Incentive Sensitization - Breakpoint0.10.10.40.20.30.1-0.1-0.70.0-0.1-0.0-0.3-0.00.20.6-0.3-0.1
Sum of active levers in priming session hrs 5-61.00.92.80.30.8-0.90.70.20.40.91.01.21.10.7-1.70.71.5
Progressive ratio0.50.61.3-0.7-1.10.8-0.8-1.1-0.8-0.8-0.5-0.8-0.5-1.00.7-0.7-0.3
Food seeking constrained by brief footshock0.10.20.6-0.7-0.80.2-0.30.0-0.3-0.3-0.3-0.2-0.3-0.50.1-0.0-0.6
Seeking ratio, punishment vs. effort0.50.60.90.50.9-0.90.81.00.80.90.40.90.40.9-0.90.90.6
Retroperitoneal fat weight0.31.02.81.41.2-0.91.11.71.31.0-0.10.9-0.31.0-0.40.70.3
Reaction time number correct0.30.54.20.1-0.60.3-0.00.50.0-0.30.1-0.3-0.1-0.60.5-0.7-2.1
Reaction time mean minus median0.50.61.7-1.1-1.10.7-0.80.3-0.8-0.8-1.2-0.5-1.3-0.50.3-0.4-0.5
Reaction time mean minus median AUC0.40.52.1-0.7-0.80.5-0.60.2-0.3-0.5-1.3-0.4-1.4-0.50.6-0.4-0.6
Reaction time num false alarms0.10.10.60.40.1-0.50.4-0.00.70.6-0.20.4-0.30.30.10.20.4
Reaction time num false alarms AUC0.10.10.4-0.1-0.2-0.20.0-0.20.30.3-0.50.2-0.6-0.10.0-0.10.4
Reaction time trials correct on left0.30.54.20.1-0.60.3-0.00.50.0-0.30.1-0.3-0.1-0.60.5-0.7-2.1
Reaction time trials on left0.30.54.50.0-0.60.3-0.10.5-0.0-0.30.0-0.4-0.1-0.70.6-0.8-2.1
Reaction time mean0.50.71.6-0.8-0.60.9-0.9-0.7-0.8-0.9-1.3-0.9-1.3-0.40.9-0.5-0.1
Reaction time mean AUC0.40.51.4-0.6-0.40.7-0.7-0.5-0.6-0.7-1.1-0.7-1.2-0.20.9-0.40.1
Median of all reaction times0.50.61.3-0.7-0.40.8-0.9-0.9-0.7-0.8-1.1-0.9-1.1-0.41.0-0.50.1
Reaction time omissions1.52.12.6-1.5-1.51.4-1.4-0.8-1.2-1.4-1.4-1.4-1.5-1.41.5-1.6-1.6
Reaction time false alarm rate0.20.22.0-0.10.2-0.30.0-0.50.20.3-0.50.3-0.50.3-0.20.31.4
Reaction time premature initiation rate0.30.41.00.91.0-0.70.60.40.90.70.50.50.40.70.00.20.1
Reaction time premature initiations0.30.51.11.10.8-0.70.70.81.00.70.50.40.30.60.2-0.0-0.8
Std. dev. reaction times0.30.41.3-0.7-0.70.7-0.7-0.1-0.5-0.7-1.1-0.7-1.1-0.20.8-0.3-0.2
Reaction time trials completed0.30.54.50.0-0.60.3-0.10.5-0.0-0.30.0-0.4-0.1-0.70.6-0.8-2.1
Reaction time trials AUC0.40.65.3-0.0-0.70.4-0.10.5-0.1-0.4-0.1-0.5-0.3-0.70.7-0.9-2.3
Run reversals in cocaine runway, females3.13.03.71.71.6-1.71.91.71.61.71.81.81.91.7-1.91.91.3
Run reversals in cocaine runway, males0.30.30.6-0.5-0.50.5-0.5-0.8-0.7-0.5-0.5-0.3-0.3-0.7-0.1-0.70.1
Latency to leave start box in cocaine runway2.93.15.21.81.4-2.01.82.32.01.91.81.81.51.8-1.41.80.7
Latency to leave start box in cocaine runway, F4.75.16.52.42.1-2.42.42.62.52.42.12.31.92.5-1.92.31.5
Latency to leave start box in cocaine runway, M0.20.21.0-0.4-0.70.4-0.40.3-0.4-0.4-0.1-0.4-0.2-0.50.4-0.4-1.0
Std. dev. time between licks in bursts1.01.22.1-1.1-0.91.4-1.3-1.4-1.4-1.3-1.1-1.2-0.9-1.10.8-0.9-0.3
Total sessions with >9 infusions1.82.03.8-2.0-1.51.4-1.5-1.0-1.8-1.5-1.0-1.2-1.0-1.60.6-1.6-1.2
Short access day 1 total inactive lever presses0.80.92.71.10.9-1.00.9-0.40.91.01.50.81.60.7-0.70.60.7
Short access day 10 total inactive lever presses0.91.02.20.80.7-1.00.9-0.10.91.01.41.01.50.7-1.00.91.2
Short access day 1 total infusions0.10.10.10.1-0.4-0.30.20.20.30.30.30.30.20.1-0.20.2-0.1
Short access day 10 total infusions0.10.10.7-0.8-0.30.1-0.3-0.1-0.4-0.20.1-0.10.1-0.5-0.2-0.5-0.4
Short access total infusions0.30.40.9-0.9-0.90.5-0.7-0.4-0.6-0.5-0.4-0.4-0.4-0.80.2-0.8-0.7
Short access day 1 locomotion0.10.10.2-0.30.00.4-0.20.4-0.4-0.4-0.3-0.2-0.2-0.1-0.0-0.1-0.5
Short access day 10 total locomotion0.20.20.5-0.40.20.4-0.4-0.7-0.3-0.3-0.6-0.5-0.6-0.10.7-0.30.0
Short access total locomotion0.40.50.9-0.9-0.30.7-0.7-0.6-0.8-0.7-0.7-0.6-0.7-0.60.5-0.7-0.6
One hour access (0.3 mA shock)0.40.41.80.40.8-0.40.51.30.40.40.90.30.70.6-0.30.1-1.0
Compulsive drug intake0.50.52.2-0.3-0.7-0.70.10.30.30.60.10.80.00.2-1.10.81.5
One hour access (shock baseline)0.30.32.10.41.00.10.20.50.1-0.00.3-0.20.20.10.4-0.6-1.4
Social response proportion2.02.23.61.21.5-1.71.41.81.41.71.11.91.01.1-1.91.31.1
Social responses0.60.81.41.01.0-1.11.00.91.01.10.71.20.70.6-1.10.50.4
Social time0.81.11.71.20.8-1.21.11.31.21.20.91.20.81.0-0.91.10.5
Soleus weight0.51.56.4-1.2-1.51.2-1.3-2.5-1.4-1.2-0.4-1.2-0.2-1.00.8-0.90.0
Bone: stiffness1.21.94.62.11.3-1.21.62.11.81.30.81.10.51.7-0.31.30.1
Tibialis anterior weight4.314.717.3-3.9-4.14.0-4.0-3.9-3.8-3.9-4.2-3.9-4.1-3.53.8-3.7-2.7
Time to tail flick, vehicle, before self-admin0.70.72.10.91.1-0.80.91.40.80.70.80.80.71.0-0.70.70.1
Time to tail flick, vehicle, after self-admin0.60.62.11.00.9-0.50.9-0.20.60.61.30.51.40.8-0.40.50.7
Time to tail flick, test, before self-admin0.20.22.00.30.20.1-0.0-0.8-0.20.00.00.10.20.2-0.30.31.4
Time to tail flick, test, after self-admin2.12.13.41.81.6-1.31.61.41.51.41.21.31.31.8-1.11.71.2
Delta time to tail flick, vehicle, before/after SA0.10.10.40.60.3-0.20.4-0.50.30.30.40.20.50.2-0.10.10.4
Delta time to tail flick, test, before/after SA1.21.12.31.11.1-1.11.21.51.41.10.71.00.61.3-0.51.0-0.0
Tibia length0.20.61.81.30.7-0.60.80.81.20.70.50.20.31.00.70.5-0.0
Ambulatory time before self-admin0.60.71.31.01.1-0.80.90.40.90.90.80.70.81.0-0.40.70.3
Ambulatory time after self-admin2.83.14.81.91.9-1.81.81.61.71.72.21.72.21.7-1.61.61.0
Bone: tissue strength1.01.01.71.20.8-1.11.11.31.21.10.91.00.81.0-0.71.00.3
Total heroin consumption1.61.92.41.51.4-1.31.51.51.31.31.61.31.51.4-1.31.40.7
Bone: trabecular number0.20.20.6-0.8-0.70.3-0.40.4-0.6-0.4-0.7-0.0-0.6-0.5-0.5-0.2-0.1
Bone: trabecular spacing0.10.10.50.30.2-0.0-0.0-0.50.30.2-0.6-0.1-0.70.00.7-0.3-0.1
Bone: trabecular thickness0.10.20.40.10.4-0.30.30.60.10.20.60.40.60.1-0.60.3-0.1
Bone: trabecular tissue density0.30.41.3-0.3-0.60.6-0.5-0.2-0.3-0.6-1.0-0.8-1.1-0.31.1-0.4-0.6
Water consumed over 24 hours1.82.13.91.31.3-1.51.52.01.31.51.51.71.51.1-1.91.10.7
Number of responses in last shaping day0.60.61.2-1.1-1.10.6-0.9-0.8-0.9-0.7-0.8-0.4-0.7-0.8-0.0-0.70.2