Hub : Genes

Sult1d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Sult1d1 0.04 0.02 4.6e-07 0.03 0.04 0.04 0.04 1.7e-05 9.6e-07 8.7e-07 1.3e-06
2 Liver alternative TSS XM_039092368.2 0.04 0.03 4.9e-04 0.01 0.03 0.03 0.02 1.2e-02 7.8e-04 3.2e-04 9.7e-04
3 Adipose gene expression Sult1d1 0.13 0.06 0.0e+00 0.15 0.16 0.17 0.17 1.9e-16 3.9e-17 3.1e-18 3.5e-18
4 Liver mRNA stability Sult1d1 0.04 0.04 1.9e-03 0.04 0.01 0.04 0.04 3.4e-05 7.3e-03 4.6e-05 3.1e-05
5 Brain mRNA stability Sult1d1 0.09 0.05 5.6e-09 0.09 0.09 0.1 0.1 6.1e-09 2.3e-08 2.4e-09 1.5e-09
6 IC gene expression Sult1d1 0.18 0.11 4.2e-07 0.11 0.09 0.1 0.09 2.4e-05 1.3e-04 4.6e-05 1.9e-04
7 pVTA gene expression Sult1d1 0.06 0.05 1.7e-04 0.07 0.04 0.04 0.05 4.5e-06 2.9e-04 4.1e-04 8.0e-05
8 BLA gene expression Sult1d1 0.28 0.12 0.0e+00 0.25 0.31 0.32 0.32 2.0e-13 1.1e-16 2.0e-17 1.8e-17
9 LHb gene expression Sult1d1 0.64 0.33 4.6e-04 0.08 0.08 0.04 0.09 6.9e-03 6.8e-03 3.2e-02 3.8e-03
10 pVTA mRNA stability Sult1d1 0.12 0.07 5.0e-07 0.08 0.05 0.08 0.09 3.5e-07 4.0e-05 4.9e-07 1.4e-07
11 PL gene expression Sult1d1 0.25 0.16 2.4e-07 0.05 0.05 0.07 0.06 3.0e-06 1.8e-06 4.0e-08 1.3e-07
12 NAcc gene expression Sult1d1 0.12 0.06 0.0e+00 0.12 0.1 0.11 0.12 1.6e-17 1.3e-15 1.1e-16 1.7e-17
13 Brain gene expression Sult1d1 0.1 0.05 9.8e-13 0.13 0.15 0.14 0.14 8.1e-12 1.3e-13 2.0e-13 5.6e-13
14 LHb mRNA stability Sult1d1 0.23 0.17 2.6e-03 0.03 0.1 0.04 0.08 6.2e-02 2.1e-03 3.7e-02 5.7e-03
15 Liver gene expression Sult1d1 0.23 0.1 1.6e-11 0.06 0.07 0.05 0.06 2.5e-07 6.0e-08 4.9e-06 1.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.10.50.30.70.30.2-0.40.30.3-0.30.1-0.2-0.50.0-0.3-0.2-0.2
Area under the delay curve0.10.10.2-0.4-0.5-0.20.10.4-0.4-0.40.10.20.2-0.1-0.10.20.2-0.2
BMI with tail1.55.26.92.42.22.62.3-2.22.62.6-2.2-2.4-2.12.52.2-1.8-2.02.0
BMI without tail0.73.85.02.22.22.22.0-2.02.12.1-1.6-1.9-1.81.81.9-1.4-1.71.9
Body weight0.00.20.60.50.80.4-0.0-0.10.40.4-0.3-0.0-0.3-0.30.6-0.1-0.40.6
Weight adjusted by age0.41.21.91.41.31.11.0-0.80.70.7-1.2-1.1-1.10.61.3-1.4-1.31.0
Bone surface0.10.21.10.10.5-0.3-0.0-0.2-0.6-0.6-0.00.4-0.1-1.10.0-0.3-0.1-0.2
Bone volume0.30.71.5-0.7-0.4-0.9-0.70.6-1.1-1.10.71.00.6-1.2-0.80.60.7-0.8
Breakpoint value in progressive ratio session0.20.30.8-0.7-0.9-0.5-0.10.2-0.8-0.80.40.30.3-0.0-0.60.50.5-0.4
Number of licking bursts0.10.41.40.61.20.50.2-0.70.80.8-0.60.1-0.5-0.70.4-0.6-0.5-0.0
Context. condit. distance diff. score0.20.31.2-0.8-1.1-0.4-0.40.6-0.5-0.50.20.00.30.7-0.3-0.20.1-0.3
Locomotion velocity, session 10.70.81.60.90.81.11.0-0.71.31.3-1.1-0.7-0.80.60.7-0.6-0.60.3
Locomotion distance, session 10.20.30.5-0.6-0.7-0.4-0.50.4-0.4-0.40.40.40.5-0.2-0.60.40.6-0.7
Locomotion velocity, session 20.10.10.4-0.4-0.6-0.2-0.40.5-0.1-0.1-0.20.30.0-0.1-0.2-0.10.2-0.6
Locomotion distance, session 20.10.10.3-0.5-0.4-0.4-0.40.3-0.2-0.20.30.40.4-0.3-0.40.30.4-0.5
Locomotion velocity, session 30.50.60.8-0.5-0.7-0.7-0.60.8-0.8-0.80.90.70.8-0.6-0.90.90.9-0.7
Locomotion distance, session 30.00.00.20.0-0.10.00.00.10.20.20.00.10.2-0.0-0.20.00.2-0.4
Stereotopy head waving bouts, day 30.40.51.00.90.90.71.0-0.60.40.4-0.7-0.6-0.80.30.8-0.5-0.81.0
Stereotopy head waving duration, day 30.10.10.30.50.50.30.5-0.30.10.1-0.3-0.3-0.30.10.3-0.1-0.30.5
Locomotion velocity, session 72.83.03.7-1.9-1.7-1.8-1.81.7-1.4-1.41.91.81.8-1.8-1.81.91.9-1.6
Locomotion distance, session 71.62.03.5-1.9-1.6-1.4-1.71.3-0.8-0.81.31.61.5-1.0-1.41.21.5-1.7
Stereotopy head waving bouts, day 70.40.51.10.90.60.61.0-0.60.00.0-0.8-0.8-0.90.50.7-0.7-0.80.8
Stereotopy head waving duration, day 70.30.41.00.80.40.71.0-0.50.10.1-0.7-0.9-0.80.70.6-0.4-0.60.8
Locomotion velocity, session 80.10.20.8-0.2-0.80.20.00.30.20.2-0.4-0.4-0.10.90.1-0.4-0.1-0.3
Locomotion distance, session 80.60.82.5-1.3-1.6-0.9-1.01.0-0.8-0.80.60.70.80.1-0.80.30.7-1.0
Degree of sensitization distance1.61.73.4-1.8-1.6-1.4-1.61.2-1.2-1.21.41.31.3-0.7-1.21.21.1-0.8
Degree of sensitization stereotypy0.10.10.40.50.20.30.6-0.3-0.2-0.2-0.4-0.4-0.40.30.1-0.3-0.20.2
Conditioned locomotion0.70.82.20.6-0.01.00.8-0.41.11.1-1.1-1.1-0.61.50.6-1.0-0.60.0
Cocaine response after cond. corrected0.50.81.4-1.0-0.9-0.8-1.00.8-0.5-0.50.71.01.0-0.7-1.10.81.0-1.2
Cocaine response after cond. not corrected0.50.71.2-0.9-0.8-0.8-0.90.7-0.7-0.70.70.90.8-0.9-1.00.70.9-1.1
Cocaine response before conditioning0.20.20.50.60.70.20.6-0.4-0.1-0.1-0.4-0.3-0.6-0.30.5-0.5-0.60.5
Saline control response0.60.91.7-1.1-1.3-0.9-0.61.0-1.0-1.01.00.71.0-0.6-0.91.01.0-0.8
Bone: connectivity density0.30.52.10.91.40.70.5-0.91.01.0-0.6-0.2-0.4-0.30.4-0.6-0.50.1
Bone: cortical apparent density0.10.21.10.30.30.50.20.01.11.1-0.1-0.00.10.0-0.10.40.3-0.2
Bone: cortical area0.61.02.2-1.0-0.6-1.2-0.80.3-1.5-1.51.31.10.6-1.2-0.61.00.60.1
Bone: cortical porosity1.82.03.11.71.71.61.4-1.01.81.8-1.6-1.2-1.30.81.3-1.5-1.20.5
Bone: cortical porosity3.23.65.22.22.32.01.8-1.62.12.1-2.0-1.6-1.91.11.9-1.9-1.91.4
Bone: cortical thickness0.20.31.10.30.70.30.4-1.10.20.2-0.1-0.2-0.70.30.7-0.4-0.71.0
Bone: cortical thickness0.20.30.9-0.6-0.3-0.6-0.40.2-0.7-0.70.40.60.3-0.9-0.40.20.3-0.5
Bone: cortical tissue density0.20.31.40.40.40.70.30.01.21.2-0.2-0.10.10.2-0.10.40.2-0.2
Condit. Reinf. active minus inactive responses0.40.51.00.60.80.60.5-0.80.70.7-0.5-0.6-0.90.50.9-0.6-0.81.0
Condit. Reinf. active-inactive response ratio2.52.74.41.41.71.51.4-1.81.41.4-1.3-1.6-1.91.42.0-1.7-1.92.1
Condit. Reinf. active responses0.00.00.10.00.2-0.1-0.30.10.30.30.20.30.1-0.3-0.10.20.2-0.2
Condit. Reinf. inactive responses1.51.93.3-1.0-0.9-1.4-1.31.4-0.9-0.91.21.61.6-1.6-1.71.51.6-1.8
Incentive salience index mean0.00.00.1-0.00.10.1-0.1-0.20.30.3-0.0-0.1-0.30.20.3-0.1-0.20.3
Condit. Reinf. lever presses0.00.10.20.20.10.30.1-0.10.50.5-0.3-0.2-0.10.20.1-0.2-0.0-0.3
Condit. Reinf. active minus inactive responses0.10.10.40.30.20.20.1-0.10.50.50.10.10.5-0.1-0.40.30.4-0.7
Condit. Reinf. active-inactive response ratio0.10.20.40.00.2-0.1-0.1-0.10.10.10.40.50.6-0.6-0.60.50.6-0.6
Condit. Reinf. active responses0.10.10.6-0.1-0.2-0.1-0.30.20.30.30.10.20.6-0.2-0.40.20.5-0.8
Condit. Reinf. inactive responses0.30.51.4-0.9-1.2-0.7-0.91.0-0.4-0.40.30.50.7-0.3-0.50.30.6-0.9
Condit. Reinf. lever presses0.40.61.0-0.6-0.7-0.6-0.50.6-0.7-0.70.90.81.0-0.7-0.90.70.9-1.0
Condit. Reinf. lever reinforcers received0.10.20.8-0.2-0.4-0.2-0.30.30.20.20.20.20.6-0.1-0.50.20.5-0.9
Conditioned reinforcement - actives0.00.20.6-0.8-0.7-0.0-0.40.5-0.5-0.5-0.3-0.1-0.10.40.2-0.4-0.2-0.1
Conditioned reinforcement - inactives0.41.02.5-0.7-1.4-0.7-0.01.4-1.6-1.60.80.40.8-0.3-1.00.91.0-0.8
Conditioned locomotion0.40.61.7-1.3-1.0-0.9-1.31.0-0.8-0.80.20.80.5-0.7-0.20.30.3-0.4
Patch foraging indifference point 0 sec0.10.41.0-0.3-0.6-0.4-0.50.6-0.3-0.30.50.60.8-0.3-0.80.60.8-1.0
Patch foraging indifference point AUC1.84.35.6-2.4-2.2-2.0-2.32.0-1.4-1.42.12.12.3-1.7-2.22.22.3-2.1
Delay disc. indifference point, 0s delay0.10.10.30.10.10.30.50.20.40.4-0.40.10.0-0.30.1-0.10.0-0.3
Delay disc. indifference point, 16s delay0.30.51.30.60.40.51.1-0.7-0.0-0.0-0.5-0.8-0.90.80.7-0.4-0.71.0
Delay disc. indifference point, 2s delay3.94.36.3-2.3-2.4-2.0-2.22.5-1.8-1.81.72.22.2-1.9-1.91.92.0-2.2
Delay disc. indifference point, 24s delay0.10.10.3-0.2-0.4-0.3-0.10.2-0.5-0.5-0.1-0.2-0.20.20.3-0.2-0.20.3
Delay disc. indifference point, 4s delay0.30.40.8-0.5-0.6-0.30.10.7-0.4-0.40.40.90.6-0.8-0.60.70.7-0.8
Delay disc. indifference point, 8s delay0.50.81.20.60.70.90.9-0.90.70.7-0.9-1.0-1.01.01.1-0.9-1.01.0
Indifference point function ln k0.72.03.21.61.41.11.6-1.30.70.7-1.3-1.4-1.71.11.6-1.5-1.71.8
Indifference point function log k0.72.03.21.61.41.11.6-1.30.70.7-1.3-1.4-1.71.11.6-1.5-1.71.8
Patch foraging total patch changes 0 sec0.20.51.1-0.5-0.8-0.6-0.60.8-0.4-0.40.60.80.9-0.4-0.90.70.9-1.1
Patch foraging total patch changes 12 sec0.91.33.5-1.7-1.5-1.1-1.91.0-0.5-0.51.11.01.2-0.3-0.91.11.1-0.9
Patch foraging total patch changes 18 sec0.10.31.5-0.2-0.2-0.2-0.30.50.00.00.40.60.9-0.6-0.80.60.8-1.2
Patch foraging total patch changes 24 sec0.51.83.3-1.7-1.8-1.3-1.71.5-1.0-1.01.11.11.4-0.4-1.41.11.4-1.5
Patch foraging total patch changes 6 sec1.72.83.6-1.7-1.8-1.6-1.61.7-1.5-1.51.71.61.8-1.3-1.91.81.9-1.8
Patch foraging time to switch 0 sec1.66.17.92.82.62.62.8-2.32.12.1-2.5-2.7-2.52.32.4-2.3-2.52.4
Patch foraging water rate 0 sec1.03.76.1-2.3-1.7-2.2-2.51.8-1.8-1.81.82.21.8-2.3-1.61.81.7-1.5
Patch foraging water rate 12 sec0.20.81.9-1.4-1.0-1.2-1.20.8-1.0-1.00.81.00.6-0.9-0.70.50.6-0.7
Patch foraging water rate 18 sec1.43.04.4-2.0-1.7-2.0-2.11.7-1.8-1.81.61.91.6-1.9-1.51.41.5-1.5
Patch foraging water rate 24 sec1.21.82.7-1.6-1.2-1.5-1.61.3-1.2-1.21.11.51.2-1.7-1.20.81.1-1.5
Patch foraging water rate 6 sec1.31.93.1-1.8-1.2-1.6-1.71.2-1.5-1.51.61.51.1-1.2-1.01.31.1-0.6
Seeking ratio, delayed vs. immediate footshock0.40.61.5-0.3-0.5-0.60.00.3-0.7-0.70.90.60.7-0.6-1.20.91.0-1.1
Distance traveled before self-admin0.00.00.20.4-0.00.10.4-0.0-0.2-0.2-0.1-0.30.10.3-0.1-0.1-0.00.1
Distance traveled after self-admin2.54.35.9-1.9-2.2-2.2-1.82.1-2.2-2.21.81.92.2-1.9-2.31.72.1-2.4
Extensor digitorum longus weight11.044.150.46.96.77.16.5-7.16.66.6-7.0-6.5-6.66.16.6-6.9-6.65.6
Bone: elastic displacement0.40.50.90.70.60.80.7-0.70.90.9-0.7-0.6-0.50.50.6-1.0-0.60.2
Bone: elastic work0.60.71.71.01.21.00.9-1.01.31.3-0.8-0.3-0.30.00.3-1.0-0.4-0.5
Bone: endosteal estimation1.53.65.5-1.9-2.0-2.1-1.72.1-2.4-2.41.91.81.7-1.9-1.71.71.7-1.5
Bone: endosteal perimeter0.20.61.6-0.5-0.2-0.9-0.40.3-1.1-1.10.80.90.6-1.3-0.70.60.6-0.5
Epididymis fat weight0.00.10.4-0.0-0.2-0.10.20.5-0.1-0.10.30.10.1-0.30.10.70.20.4
Delta time in closed arm before/after self-admin0.90.81.30.71.01.00.4-1.00.70.7-0.8-1.0-1.10.71.1-0.9-1.01.1
Delta time in open arm before/after self-admin0.40.51.1-0.6-1.0-0.8-0.20.9-0.6-0.60.70.60.9-0.1-0.91.00.8-0.6
Diff in mean of infusions in LGA sessions0.10.20.9-0.0-0.3-0.00.5-0.3-0.3-0.30.0-0.5-0.40.90.1-0.2-0.30.7
Delay discount exponential model param0.10.20.40.60.60.30.1-0.60.60.6-0.3-0.4-0.40.20.2-0.4-0.30.3
Extinction: sum of active levers before priming0.10.10.30.30.20.30.3-0.30.50.5-0.3-0.1-0.10.10.0-0.4-0.2-0.3
Active lever presses in extinction session 60.80.81.6-0.8-0.6-1.0-0.80.8-0.7-0.71.01.00.8-1.3-0.80.90.8-0.7
Bone: final force0.20.41.7-0.40.1-0.8-0.50.2-0.8-0.80.70.80.2-1.3-0.20.50.20.1
Bone: final moment0.30.42.0-0.40.1-0.8-0.50.2-0.9-0.90.70.90.2-1.4-0.20.50.20.1
Food consumed during 24 hour testing period1.02.15.5-1.4-1.3-1.2-1.51.3-0.6-0.61.11.61.8-1.1-1.81.11.6-2.3
Glucose0.71.11.7-1.3-1.3-1.1-1.31.1-1.0-1.01.11.01.1-0.6-1.01.01.0-0.8
Heart weight0.50.83.10.80.70.50.6-0.90.10.1-0.4-0.9-1.10.81.2-0.6-1.11.8
Delay discount hyperbolic model param0.30.40.80.90.90.50.4-0.80.70.7-0.5-0.7-0.60.40.5-0.6-0.60.6
Intermittent access intake day 1-15 change0.10.40.90.60.70.60.3-0.20.50.5-1.0-0.8-0.70.60.7-0.8-0.70.5
Intermittent access intake escalation0.10.71.00.91.00.80.6-0.50.50.5-1.0-1.0-0.90.71.0-0.9-0.90.9
Intermittent access intake escalation 20.40.61.8-0.5-0.7-0.8-0.41.2-1.3-1.30.70.40.4-0.8-0.40.70.5-0.2
Intermitt. access day 1 inactive lever presses0.23.07.1-2.2-2.7-1.6-1.32.2-1.3-1.31.71.21.90.0-2.01.61.9-1.8
Intermitt. access day 15 inactive lever presses0.84.56.2-2.5-2.5-2.2-2.02.5-1.9-1.92.12.12.2-1.6-2.12.12.2-2.0
Intermitt. access escalation Index0.51.62.81.41.61.41.7-1.61.41.4-0.9-1.2-1.01.00.9-1.0-1.00.9
Intermittent access day 1 total infusions0.00.10.2-0.3-0.40.0-0.10.40.10.1-0.30.20.1-0.0-0.1-0.20.1-0.5
Intermittent access day 15 total infusions0.00.10.2-0.1-0.2-0.1-0.20.4-0.4-0.4-0.3-0.1-0.10.10.1-0.3-0.1-0.0
Intermittent access terminal intake (last 3 days)0.61.02.2-1.0-1.2-1.0-1.01.4-1.5-1.50.70.80.8-0.7-0.80.70.8-0.7
Intermittent access total infusions0.10.10.3-0.2-0.3-0.2-0.20.4-0.6-0.60.00.30.3-0.2-0.30.10.2-0.3
Intermittent access day 1 locomotion0.30.61.4-1.2-1.2-0.6-0.91.1-0.5-0.50.40.70.7-0.3-0.60.40.7-1.0
Intermittent access day 15 total locomotion0.20.71.8-1.1-1.1-0.9-1.31.3-1.2-1.20.20.60.5-0.6-0.20.40.3-0.2
Intermittent access total locomotion0.10.10.4-0.4-0.3-0.2-0.70.6-0.5-0.5-0.20.30.1-0.50.20.0-0.00.0
Intermittent access standard deviation0.20.91.5-0.9-1.2-0.8-0.81.2-1.1-1.10.90.71.0-0.3-0.90.81.0-0.9
Left kidney weight0.00.31.1-0.2-0.1-0.7-0.70.5-0.9-0.90.60.60.2-1.00.10.30.00.4
Right kidney weight0.21.23.5-0.6-0.2-1.2-1.40.8-1.3-1.31.41.30.7-1.9-0.41.20.60.2
Cocaine induced anxiety0.10.20.50.40.70.50.3-0.60.40.4-0.2-0.2-0.40.20.4-0.2-0.40.5
Post-drug Anxiety0.00.00.3-0.1-0.10.00.2-0.2-0.1-0.10.2-0.2-0.10.50.00.2-0.00.3
Baseline Anxiety0.10.20.7-0.3-0.8-0.5-0.00.5-0.5-0.50.20.00.30.2-0.50.00.3-0.5
Tail length0.42.14.4-1.3-1.0-1.6-1.61.6-1.5-1.51.51.71.4-2.1-1.21.31.2-1.1
Length with tail0.73.17.3-1.5-1.1-2.0-2.12.0-2.2-2.21.72.01.4-2.7-1.01.41.2-0.9
Length without tail0.31.42.7-1.2-1.0-1.3-1.61.5-1.3-1.31.01.41.0-1.5-0.60.80.7-0.6
Times rat made contact with spout0.20.20.7-0.2-0.0-0.3-0.20.3-0.1-0.10.30.60.4-0.9-0.60.50.6-0.7
Lifetime Intake0.10.10.20.40.30.50.4-0.10.10.1-0.5-0.2-0.20.20.2-0.4-0.2-0.1
Liver weight, left0.81.52.3-1.2-1.1-1.1-1.01.4-0.7-0.71.11.31.3-1.5-1.31.41.4-1.4
Liver weight, right1.62.84.4-1.8-1.6-1.5-1.72.1-1.0-1.01.41.91.8-1.6-1.71.61.8-1.9
Locomotor activity1.01.52.6-1.5-1.3-1.5-1.61.6-1.6-1.60.81.20.8-1.3-0.50.50.6-0.8
Locomotor testing distance0.10.30.9-0.4-0.4-0.7-0.70.7-0.9-0.90.20.40.2-0.5-0.0-0.2-0.0-0.2
Locomotor testing rearing0.00.00.2-0.1-0.0-0.3-0.20.2-0.4-0.40.10.10.2-0.2-0.0-0.3-0.1-0.1
Locomotion in novel chamber0.00.00.1-0.00.1-0.1-0.10.10.20.20.10.30.2-0.00.10.0-0.00.1
Locomotion in novel chamber post-restriction0.30.81.6-0.5-0.3-0.9-0.40.7-1.1-1.11.30.90.7-1.1-0.91.20.8-0.3
Fecal boli incidents, locomotor time 10.82.24.22.02.11.42.0-2.00.80.8-0.9-1.0-1.60.61.3-1.2-1.51.7
Change in fecal boli incidents, locomotor task0.30.41.10.70.50.70.50.21.01.0-1.0-0.4-0.20.10.3-0.6-0.2-0.4
Time >=10cm from walls, locomotor time 11.92.45.61.91.81.72.4-1.51.41.4-1.7-1.5-1.61.01.2-1.4-1.20.8
Bouts of movement, locomotor time 10.81.13.01.31.50.91.2-1.10.50.5-0.6-0.9-0.90.71.0-0.6-1.11.7
Total resting periods, locomotor time 10.60.72.11.21.40.81.1-0.90.40.4-0.5-0.7-0.70.50.8-0.4-0.91.4
Rest time, locomotor task time 10.30.51.5-0.00.3-0.8-0.60.5-0.6-0.60.80.80.8-1.2-0.70.50.5-0.5
Distance moved, locomotor task time 10.10.20.5-0.1-0.20.60.3-0.20.60.6-0.6-0.4-0.40.70.4-0.5-0.3-0.1
Vertical activity count, locomotor time 10.10.51.5-1.2-1.2-0.5-0.90.6-0.3-0.30.50.50.5-0.2-0.40.80.7-0.5
Time >=10cm from walls, locomotor time 20.31.02.51.21.21.21.6-0.81.31.3-1.2-0.7-0.70.30.3-1.0-0.6-0.3
Bouts of movement, locomotor time 20.10.20.7-0.1-0.3-0.40.20.6-0.8-0.80.30.20.3-0.3-0.30.30.3-0.2
Total resting periods, locomotor time 20.00.10.5-0.0-0.1-0.30.20.5-0.7-0.70.20.10.1-0.3-0.10.20.2-0.1
Rest time, locomotor task time 20.20.30.7-0.3-0.1-0.7-0.80.8-0.4-0.40.20.40.6-0.8-0.50.10.4-0.7
Distance moved, locomotor task time 20.81.12.20.70.91.30.7-1.21.51.5-0.9-0.7-0.91.01.1-1.0-1.00.8
Vertical activity count, locomotor time 20.00.10.3-0.5-0.2-0.0-0.5-0.10.40.40.50.50.2-0.2-0.10.50.3-0.1
Light reinforcement 10.31.52.3-1.4-1.1-1.3-1.30.9-1.4-1.41.51.21.1-1.0-1.11.21.1-0.8
Light reinforcement 20.00.10.20.40.30.20.4-0.50.10.1-0.20.0-0.2-0.10.0-0.1-0.10.1
Bone: marrow area1.43.45.4-1.8-2.0-2.1-1.62.0-2.3-2.31.81.71.6-1.8-1.61.61.6-1.4
Bone: maximum diameter0.10.30.9-0.30.1-0.6-0.2-0.2-0.9-0.90.80.5-0.0-0.80.00.60.00.7
Bone: maximum force0.40.82.5-0.8-0.2-1.1-0.70.4-1.2-1.21.01.10.5-1.6-0.50.60.4-0.2
Bone: maximum moment0.51.03.2-0.9-0.2-1.2-0.80.5-1.4-1.41.11.30.5-1.8-0.50.70.5-0.2
Mean time between licks in bursts0.84.67.62.32.41.91.6-2.22.02.0-1.8-2.0-2.31.72.6-2.0-2.42.8
Mean num. licks in bursts0.41.22.4-1.1-1.5-1.0-0.71.3-1.2-1.21.20.61.1-0.2-1.11.31.2-0.8
Cd content in liver5.15.76.62.32.02.52.6-2.61.91.9-2.3-2.5-2.52.42.5-2.4-2.52.5
Co content in liver0.20.20.60.60.80.20.1-0.60.60.6-0.3-0.2-0.3-0.10.3-0.3-0.40.4
Cu content in liver0.10.10.3-0.4-0.3-0.3-0.1-0.2-0.4-0.40.30.50.2-0.5-0.40.30.2-0.1
Fe content in liver0.10.20.70.40.80.20.3-0.30.10.1-0.50.2-0.5-0.90.5-0.3-0.40.3
K content in liver0.60.61.1-0.8-1.0-0.5-0.60.8-0.3-0.30.60.61.00.0-1.10.81.0-1.0
Mg content in liver0.20.20.5-0.4-0.5-0.4-0.30.3-0.1-0.10.40.30.60.0-0.70.70.6-0.4
Mn content in liver0.20.20.60.2-0.00.30.3-0.40.10.1-0.5-0.6-0.50.80.3-0.5-0.50.4
Na content in liver0.60.71.8-0.7-0.3-0.6-0.60.7-0.3-0.30.61.01.0-1.2-1.00.91.1-1.3
Rb content in liver1.21.42.01.21.41.10.9-1.31.31.3-1.0-1.0-1.30.91.2-1.0-1.21.4
Se content in liver0.10.10.2-0.3-0.4-0.4-0.50.4-0.1-0.10.40.40.3-0.0-0.30.40.3-0.1
Sr content in liver0.30.20.70.10.10.10.5-0.5-0.3-0.3-0.2-0.5-0.60.30.6-0.6-0.70.8
Zn content in liver0.60.71.70.70.60.90.4-0.91.31.3-0.8-0.7-0.51.30.5-0.7-0.60.4
Bone: minimum diameter7.013.417.3-3.8-3.4-4.2-3.63.4-4.1-4.14.13.93.5-3.9-3.23.73.3-2.4
Time in familiar zone, hab. session 10.10.10.5-0.4-0.6-0.1-0.20.1-0.0-0.0-0.00.10.20.4-0.3-0.20.2-0.7
Time in novel zone, hab. session 10.20.20.90.60.80.40.5-0.40.20.2-0.2-0.3-0.5-0.20.50.1-0.41.0
Total zone transitions, hab. session 10.10.20.8-0.20.0-0.0-0.10.1-0.2-0.20.20.50.5-0.7-0.60.30.5-0.9
Total locomotion distance, hab. session 11.42.04.0-1.3-1.4-1.3-1.21.6-1.1-1.11.21.51.6-1.4-1.61.21.6-2.0
Locomotion velocity, hab. session 11.01.43.0-1.0-1.2-1.1-0.91.3-1.0-1.01.01.21.4-1.2-1.40.91.3-1.7
Time in familiar zone, hab. session 20.30.30.60.60.40.80.8-0.60.50.5-0.8-0.5-0.40.70.1-0.6-0.3-0.2
Time in novel zone, hab. session 20.30.31.1-0.6-0.2-0.6-0.50.3-0.7-0.70.90.20.0-0.40.30.70.01.1
Total zone transitions, hab. session 20.10.10.40.40.60.10.4-0.4-0.4-0.40.20.2-0.1-0.6-0.0-0.1-0.10.0
Total locomotion distance, hab. session 20.50.61.7-0.4-0.3-0.8-0.40.5-1.0-1.01.00.90.7-1.3-0.80.70.7-0.7
Locomotion velocity, hab. session 20.40.61.6-0.3-0.3-0.7-0.30.5-0.9-0.90.80.80.7-1.3-0.80.60.7-0.9
Novel to familiar place preference ratio0.10.20.6-0.20.0-0.4-0.60.30.00.00.50.50.4-0.6-0.40.80.5-0.2
Novelty place preference0.10.10.40.00.4-0.1-0.20.00.20.20.20.20.1-0.5-0.20.60.30.1
Time in novel zone, NPP test0.20.20.8-0.20.1-0.4-0.50.3-0.1-0.10.50.50.4-0.7-0.40.90.5-0.1
Total zone transitions, NPP test0.00.00.10.20.40.30.2-0.20.10.10.00.10.1-0.2-0.30.10.2-0.3
Total locomotion distance, NPP test0.10.20.7-0.10.1-0.2-0.20.2-0.1-0.10.30.50.4-0.7-0.50.10.4-0.8
Locomotion velocity, NPP test0.10.10.30.30.40.30.2-0.20.30.3-0.10.10.1-0.3-0.2-0.20.1-0.5
Intraocular pressure0.40.71.81.11.30.80.7-1.00.80.8-0.8-0.3-0.8-0.20.8-0.6-0.80.9
Delta distance traveled before/after self-admin3.33.66.0-2.1-1.8-1.9-2.32.0-1.2-1.21.52.02.0-2.1-1.91.41.9-2.4
Delta ambulatory time before/after self-admin1.01.73.1-1.5-1.2-1.4-1.71.3-0.7-0.71.01.41.4-1.5-1.31.01.3-1.8
Parametrial fat weight1.73.95.2-2.0-1.7-1.9-2.12.1-1.3-1.31.92.32.1-2.1-2.12.12.2-2.1
Pavlov. Cond. lever latency1.41.73.31.81.81.41.6-1.41.31.3-1.4-1.1-1.20.51.1-1.4-1.20.8
Pavlov. Cond. magazine entry latency0.10.10.50.0-0.20.3-0.1-0.20.40.4-0.5-0.3-0.20.70.1-0.5-0.1-0.3
Pavlov. Cond. change in total contacts0.30.31.0-0.8-1.0-0.6-0.70.5-0.6-0.60.60.20.20.3-0.10.40.20.2
Pavlov. Cond. index score0.40.51.5-1.0-1.2-0.6-1.00.7-0.4-0.40.50.40.60.1-0.50.50.7-0.7
Pavlov. Cond. latency score0.50.61.7-1.2-1.3-0.7-1.20.8-0.5-0.50.70.50.70.1-0.60.70.7-0.7
Pavlov. Cond. lever contacts1.21.52.7-1.7-1.6-1.3-1.51.2-1.3-1.31.31.01.0-0.6-0.91.21.0-0.6
Pavlov. Cond. magazine entry number0.00.00.20.30.40.10.4-0.1-0.1-0.10.20.10.1-0.4-0.10.20.00.1
Pavlov. Cond. intertrial magazine entries0.50.71.2-0.6-0.5-0.9-0.60.9-1.1-1.11.00.80.6-1.0-0.61.10.7-0.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.5-1.0-1.2-0.6-1.00.8-0.4-0.40.50.50.70.1-0.60.60.7-0.8
Pavlov. Cond. response bias0.30.41.1-0.9-1.0-0.6-0.90.7-0.4-0.40.40.40.6-0.1-0.60.50.7-0.8
Pavlov. Cond. lever latency0.40.51.0-1.0-0.8-0.9-1.00.7-0.8-0.80.70.60.5-0.4-0.50.80.5-0.0
Pavlov. Cond. magazine entry latency1.52.13.91.92.01.41.4-1.61.41.4-1.4-1.3-1.40.91.3-1.5-1.41.0
Pavlov. Cond. change in total contacts0.30.71.21.10.90.81.0-0.90.70.7-0.9-0.8-0.70.60.7-1.0-0.80.4
Pavlov. Cond. index score0.81.32.31.51.41.21.4-1.21.11.1-1.1-1.0-1.00.61.0-1.3-1.00.5
Pavlov. Cond. latency score1.11.82.91.71.51.41.5-1.41.21.2-1.3-1.3-1.30.91.2-1.6-1.30.8
Pavlov. Cond. lever contacts0.10.10.40.60.50.40.6-0.30.40.4-0.2-0.2-0.1-0.10.1-0.4-0.1-0.3
Pavlov. Cond. magazine entry number2.53.35.5-2.3-2.3-1.8-1.82.0-1.8-1.81.81.61.8-1.0-1.72.01.8-1.2
Pavlov. Cond. intertrial magazine entries1.32.94.0-1.9-1.8-1.5-1.61.6-1.5-1.51.81.61.9-1.3-1.82.01.9-1.5
Pavlov. Cond. lever-magazine prob. diff.0.81.22.21.51.31.11.3-1.11.11.1-1.1-1.0-1.00.60.9-1.3-1.00.5
Pavlov. Cond. response bias0.60.81.61.31.21.01.2-0.91.01.0-0.9-0.8-0.70.30.7-1.0-0.70.2
Time in closed arm before self-admin0.50.91.9-0.9-1.0-1.4-1.01.2-1.1-1.11.21.00.8-0.8-0.51.00.60.0
Time in closed arm after self-admin0.20.31.6-0.0-0.1-0.2-0.30.3-0.5-0.50.2-0.3-0.50.30.7-0.2-0.61.3
Time in open arm before self-admin0.50.61.80.10.70.9-0.3-0.71.01.0-1.1-0.4-0.70.40.7-1.3-0.8-0.1
Time in open arm after self-admin0.70.72.6-0.5-0.7-0.4-0.10.6-0.2-0.20.40.91.2-0.7-1.30.91.2-1.6
Bone: periosteal estimation1.12.55.2-1.6-1.4-1.9-1.41.3-2.3-2.31.81.61.2-1.7-1.21.41.2-0.7
Bone: periosteal perimeter0.30.51.4-0.6-0.2-0.9-0.50.0-1.2-1.20.90.90.4-1.1-0.60.60.4-0.2
Bone: post-yield work0.30.51.8-0.6-0.4-0.8-0.30.6-1.3-1.30.60.70.2-0.9-0.30.50.30.1
Progressive ratio test 1 active lever presses0.10.20.6-0.4-0.2-0.3-0.50.7-0.6-0.60.10.40.0-0.80.2-0.1-0.10.0
Progressive ratio test 1 breakpoint0.10.20.6-0.3-0.2-0.3-0.40.7-0.6-0.60.10.40.1-0.80.1-0.1-0.1-0.1
Progressive ratio test 1 inactive lever presses1.12.95.4-1.9-2.3-1.4-1.22.1-1.4-1.41.81.41.9-0.4-2.01.71.9-2.0
Progressive ratio test 2 active lever presses0.20.31.4-0.6-0.7-0.5-0.50.6-1.2-1.20.20.1-0.0-0.10.10.1-0.00.3
Progressive ratio test 2 breakpoint0.20.31.5-0.5-0.7-0.5-0.40.6-1.2-1.20.20.1-0.0-0.10.10.1-0.00.3
Progressive ratio test 2 inactive lever presses0.61.93.2-1.6-1.7-1.4-1.31.7-1.8-1.81.31.11.2-0.7-1.31.21.3-1.1
Incentive Sensitization - Responses0.10.30.70.3-0.30.10.5-0.1-0.7-0.7-0.3-0.7-0.50.80.4-0.2-0.40.7
Incentive Sensitization - Breakpoint0.10.30.60.2-0.40.00.5-0.0-0.7-0.7-0.3-0.7-0.50.80.4-0.2-0.40.7
Sum of active levers in priming session hrs 5-60.20.21.0-0.7-1.00.00.20.1-0.2-0.20.1-0.10.20.7-0.5-0.00.4-0.7
Progressive ratio0.00.10.20.20.30.40.4-0.40.30.3-0.1-0.0-0.00.20.0-0.2-0.1-0.0
Food seeking constrained by brief footshock0.20.31.30.71.10.60.3-0.50.80.8-0.5-0.5-0.30.10.3-0.4-0.40.1
Seeking ratio, punishment vs. effort0.30.61.1-0.8-0.8-0.9-0.91.0-0.7-0.70.60.50.7-0.7-0.70.90.8-0.7
Retroperitoneal fat weight0.21.01.9-1.1-0.7-1.1-1.11.2-0.8-0.81.21.20.8-1.4-0.51.20.8-0.3
Reaction time number correct0.00.10.4-0.00.5-0.10.0-0.7-0.3-0.30.10.3-0.3-0.60.1-0.1-0.20.4
Reaction time mean minus median0.10.61.31.11.21.00.9-0.80.90.9-0.7-0.2-0.6-0.20.7-0.5-0.60.5
Reaction time mean minus median AUC0.00.30.70.60.60.70.6-0.70.40.4-0.3-0.3-0.60.10.6-0.0-0.40.8
Reaction time num false alarms0.20.41.5-1.2-0.8-0.4-0.8-0.1-0.2-0.21.00.50.40.4-0.50.80.60.1
Reaction time num false alarms AUC0.10.10.5-0.6-0.30.1-0.3-0.40.40.40.40.00.10.7-0.20.40.20.2
Reaction time trials correct on left0.00.10.4-0.00.5-0.10.0-0.7-0.3-0.30.10.3-0.3-0.60.1-0.1-0.20.4
Reaction time trials on left0.00.10.50.00.6-0.10.0-0.7-0.2-0.20.10.3-0.4-0.50.2-0.2-0.30.4
Reaction time mean0.40.82.51.20.71.01.6-0.60.70.7-0.8-0.9-0.90.61.0-0.5-0.81.0
Reaction time mean AUC0.30.62.11.00.60.81.5-0.50.60.6-0.6-0.8-0.80.50.8-0.3-0.71.0
Median of all reaction times0.50.72.41.00.50.81.5-0.50.60.6-0.7-1.0-0.80.80.9-0.5-0.71.0
Reaction time omissions1.01.62.01.41.41.21.2-1.41.31.3-1.1-0.9-1.30.81.4-1.2-1.41.3
Reaction time false alarm rate0.10.20.8-0.6-0.60.1-0.30.00.40.40.3-0.10.30.9-0.20.40.30.0
Reaction time premature initiation rate0.60.91.7-0.7-1.1-1.0-0.41.2-1.3-1.31.20.60.9-0.5-0.71.10.8-0.2
Reaction time premature initiations0.31.02.1-0.8-1.0-1.2-0.60.9-1.5-1.51.30.90.8-0.9-0.71.20.8-0.0
Std. dev. reaction times0.10.51.01.00.70.81.0-0.50.60.6-0.5-0.4-0.60.10.9-0.4-0.60.9
Reaction time trials completed0.00.10.50.00.6-0.10.0-0.7-0.2-0.20.10.3-0.4-0.50.2-0.2-0.30.4
Reaction time trials AUC0.00.20.60.00.7-0.00.0-0.8-0.2-0.20.00.3-0.5-0.60.3-0.2-0.30.5
Run reversals in cocaine runway, females2.83.14.7-2.2-1.7-2.0-2.01.8-1.8-1.81.72.01.6-1.8-1.61.51.5-1.4
Run reversals in cocaine runway, males0.30.31.1-0.10.10.4-0.0-0.40.70.7-0.8-0.6-0.61.10.5-0.7-0.50.2
Latency to leave start box in cocaine runway1.62.33.8-0.8-0.7-1.5-0.80.8-1.6-1.61.91.71.6-1.9-1.92.01.7-1.2
Latency to leave start box in cocaine runway, F3.94.96.8-1.8-1.9-2.2-1.81.8-2.2-2.22.42.32.4-2.2-2.52.62.5-1.9
Latency to leave start box in cocaine runway, M0.20.21.20.61.10.00.4-0.70.20.20.20.2-0.1-0.7-0.20.10.0-0.0
Std. dev. time between licks in bursts0.81.62.31.11.01.20.9-1.01.51.5-1.4-1.2-1.31.21.5-1.5-1.41.0
Total sessions with >9 infusions1.21.52.41.41.41.61.3-1.01.31.3-1.5-1.0-1.20.61.3-1.4-1.20.7
Short access day 1 total inactive lever presses0.30.61.3-0.5-1.2-0.7-0.31.0-1.1-1.10.80.30.90.0-0.90.60.9-1.0
Short access day 10 total inactive lever presses0.21.52.3-1.2-1.5-1.3-1.01.2-1.3-1.31.50.81.3-0.1-1.41.31.3-0.9
Short access day 1 total infusions0.10.20.4-0.2-0.2-0.3-0.40.4-0.4-0.40.40.30.5-0.3-0.60.40.5-0.6
Short access day 10 total infusions0.20.40.80.50.40.90.9-0.40.80.8-0.9-0.5-0.40.30.2-0.7-0.3-0.4
Short access total infusions0.50.81.31.10.91.11.1-0.81.11.1-1.1-0.7-0.70.60.5-0.9-0.6-0.0
Short access day 1 locomotion0.10.20.60.10.40.40.00.10.60.6-0.80.2-0.2-0.80.4-0.7-0.4-0.4
Short access day 10 total locomotion0.00.10.30.0-0.40.10.30.3-0.0-0.0-0.1-0.3-0.10.50.1-0.1-0.10.2
Short access total locomotion0.20.30.80.50.30.70.6-0.10.70.7-0.9-0.3-0.40.10.5-0.7-0.4-0.0
One hour access (0.3 mA shock)0.30.31.9-0.2-0.2-0.4-0.30.7-0.7-0.70.10.60.3-1.4-0.40.20.4-0.7
Compulsive drug intake0.20.30.80.50.50.20.7-0.50.40.40.40.10.5-0.5-0.80.40.7-0.9
One hour access (shock baseline)0.10.20.7-0.6-0.6-0.5-0.70.8-0.8-0.8-0.10.3-0.0-0.40.2-0.0-0.10.1
Social response proportion1.11.53.1-0.7-1.1-0.9-0.61.0-0.7-0.71.01.21.3-1.3-1.71.61.7-1.8
Social responses0.71.01.6-1.1-1.3-1.0-1.10.9-0.9-0.90.80.90.9-0.7-1.11.11.1-1.0
Social time0.40.71.4-0.6-0.6-0.9-0.30.4-1.2-1.20.90.70.7-0.8-1.11.00.9-0.6
Soleus weight0.51.54.30.80.31.41.1-1.01.01.0-1.3-1.4-1.12.11.3-1.7-1.30.8
Bone: stiffness1.42.65.0-1.7-1.2-1.9-1.61.3-2.2-2.21.81.71.1-1.9-1.11.71.2-0.4
Tibialis anterior weight3.913.315.53.53.33.83.7-3.93.13.1-3.7-3.8-3.83.73.9-3.6-3.83.8
Time to tail flick, vehicle, before self-admin1.61.93.7-1.3-1.1-1.7-1.61.5-1.3-1.31.21.51.4-1.9-1.21.21.2-1.2
Time to tail flick, vehicle, after self-admin0.61.22.2-1.5-1.4-1.2-1.11.2-1.3-1.30.91.10.8-0.8-0.90.40.7-0.9
Time to tail flick, test, before self-admin0.10.10.4-0.4-0.5-0.1-0.10.10.20.20.0-0.1-0.10.70.2-0.2-0.20.1
Time to tail flick, test, after self-admin2.02.13.2-1.6-1.5-1.6-1.71.8-1.5-1.51.41.61.2-1.6-1.11.31.3-1.1
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.7-0.7-0.2-0.20.3-0.5-0.50.20.10.00.4-0.1-0.00.1-0.1
Delta time to tail flick, test, before/after SA1.01.22.2-0.9-0.8-1.1-0.91.0-1.3-1.31.01.21.0-1.5-1.01.21.1-0.8
Tibia length0.41.02.2-1.1-1.0-1.5-1.00.8-1.3-1.31.40.80.6-0.8-0.51.20.60.4
Ambulatory time before self-admin0.00.10.40.2-0.3-0.10.20.1-0.6-0.60.1-0.20.10.4-0.10.00.00.1
Ambulatory time after self-admin2.43.94.9-1.8-1.9-2.1-1.82.0-2.0-2.01.81.82.2-1.9-2.21.72.0-2.2
Bone: tissue strength0.91.01.8-1.0-0.6-1.1-1.01.0-0.9-0.91.21.30.9-1.1-0.91.00.9-0.6
Total heroin consumption0.70.82.0-1.3-0.9-1.1-1.41.0-0.8-0.80.71.00.7-1.0-0.70.50.5-0.7
Bone: trabecular number0.10.10.40.30.60.30.1-0.20.50.5-0.10.20.1-0.5-0.20.10.2-0.5
Bone: trabecular spacing0.20.20.8-0.5-0.8-0.2-0.20.3-0.5-0.50.3-0.3-0.10.90.20.40.00.7
Bone: trabecular thickness0.10.20.5-0.4-0.1-0.2-0.30.5-0.3-0.30.30.60.3-0.7-0.60.20.4-0.7
Bone: trabecular tissue density0.30.61.60.70.90.60.6-0.90.40.4-0.7-0.7-1.00.60.9-0.5-0.91.3
Water consumed over 24 hours0.91.83.7-1.2-0.8-1.3-1.41.2-1.0-1.01.11.71.4-1.9-1.41.21.3-1.6
Number of responses in last shaping day0.30.42.00.30.50.90.6-0.11.41.4-0.5-0.3-0.20.40.3-0.5-0.2-0.3