Hub : Genes

Sult1b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Sult1b1 0.19 0.09 0.0e+00 0.15 0.13 0.13 0.14 5.1e-16 2.2e-14 1.5e-14 5.1e-15
2 Adipose gene expression Sult1b1 0.03 0.02 8.6e-03 0.01 0 0.01 0 2.3e-02 2.1e-01 1.0e-02 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.00.00.00.0-0.0
Area under the delay curve0.20.20.3-0.3-0.6
BMI with tail0.72.34.62.10.0
BMI without tail0.61.73.31.8-0.3
Body weight0.10.30.50.7-0.4
Weight adjusted by age1.21.82.31.51.1
Bone surface0.10.20.30.10.6
Bone volume0.20.40.7-0.8-0.3
Breakpoint value in progressive ratio session0.50.60.9-0.6-0.9
Number of licking bursts0.20.30.30.60.5
Context. condit. distance diff. score0.60.71.30.21.2
Locomotion velocity, session 10.10.10.10.3-0.3
Locomotion distance, session 10.10.10.2-0.5-0.2
Locomotion velocity, session 20.10.10.1-0.40.3
Locomotion distance, session 20.10.10.2-0.5-0.2
Locomotion velocity, session 30.60.71.0-1.0-0.6
Locomotion distance, session 30.00.00.1-0.1-0.3
Stereotopy head waving bouts, day 30.40.40.80.90.3
Stereotopy head waving duration, day 30.00.00.10.30.1
Locomotion velocity, session 73.53.94.3-2.1-1.8
Locomotion distance, session 71.31.62.4-1.5-0.9
Stereotopy head waving bouts, day 70.40.40.50.70.6
Stereotopy head waving duration, day 70.10.10.20.5-0.1
Locomotion velocity, session 80.20.20.40.10.6
Locomotion distance, session 80.30.40.5-0.50.7
Degree of sensitization distance0.90.91.6-1.2-0.5
Degree of sensitization stereotypy0.00.00.00.20.2
Conditioned locomotion0.40.50.50.70.7
Cocaine response after cond. corrected0.70.81.1-1.1-0.7
Cocaine response after cond. not corrected0.40.50.7-0.9-0.4
Cocaine response before conditioning0.30.40.50.50.7
Saline control response0.50.70.8-0.8-0.9
Bone: connectivity density0.10.10.20.5-0.1
Bone: cortical apparent density1.21.62.9-0.5-1.7
Bone: cortical area0.50.70.7-0.8-0.8
Bone: cortical porosity1.21.31.51.21.1
Bone: cortical porosity2.42.73.51.91.3
Bone: cortical thickness0.00.10.10.30.1
Bone: cortical thickness0.10.10.1-0.40.2
Bone: cortical tissue density1.11.42.7-0.4-1.6
Condit. Reinf. active minus inactive responses0.30.30.50.70.3
Condit. Reinf. active-inactive response ratio2.42.63.51.91.3
Condit. Reinf. active responses0.10.10.1-0.3-0.2
Condit. Reinf. inactive responses1.72.02.9-1.7-1.1
Incentive salience index mean0.00.00.00.2-0.1
Condit. Reinf. lever presses0.00.00.00.00.0
Condit. Reinf. active minus inactive responses0.20.30.3-0.5-0.6
Condit. Reinf. active-inactive response ratio0.40.50.7-0.5-0.8
Condit. Reinf. active responses0.10.10.2-0.5-0.1
Condit. Reinf. inactive responses0.20.20.3-0.50.4
Condit. Reinf. lever presses0.20.30.6-0.7-0.2
Condit. Reinf. lever reinforcers received0.10.10.3-0.5-0.0
Conditioned reinforcement - actives0.10.30.50.20.7
Conditioned reinforcement - inactives0.81.11.4-0.9-1.2
Conditioned locomotion0.30.40.8-0.20.9
Patch foraging indifference point 0 sec0.30.50.6-0.8-0.7
Patch foraging indifference point AUC3.75.46.1-2.5-2.1
Delay disc. indifference point, 0s delay0.10.20.3-0.0-0.6
Delay disc. indifference point, 16s delay0.20.20.20.5-0.5
Delay disc. indifference point, 2s delay2.52.74.0-2.0-1.2
Delay disc. indifference point, 24s delay0.20.20.30.20.6
Delay disc. indifference point, 4s delay1.31.42.2-0.8-1.5
Delay disc. indifference point, 8s delay0.40.40.80.90.3
Indifference point function ln k1.83.13.51.91.7
Indifference point function log k1.83.13.51.91.7
Patch foraging total patch changes 0 sec0.40.70.7-0.9-0.8
Patch foraging total patch changes 12 sec0.91.11.3-1.1-1.0
Patch foraging total patch changes 18 sec0.91.41.7-1.1-1.3
Patch foraging total patch changes 24 sec0.91.52.9-1.7-0.3
Patch foraging total patch changes 6 sec2.23.33.9-2.0-1.7
Patch foraging time to switch 0 sec1.73.65.32.31.4
Patch foraging water rate 0 sec0.61.32.1-1.4-0.7
Patch foraging water rate 12 sec0.10.20.4-0.30.6
Patch foraging water rate 18 sec0.40.61.3-1.1-0.0
Patch foraging water rate 24 sec0.30.40.6-0.80.3
Patch foraging water rate 6 sec0.40.71.0-1.0-0.5
Seeking ratio, delayed vs. immediate footshock1.31.61.8-1.2-1.3
Distance traveled before self-admin0.10.10.1-0.20.3
Distance traveled after self-admin2.22.75.2-2.3-0.5
Extensor digitorum longus weight8.232.443.66.64.6
Bone: elastic displacement0.60.71.00.71.0
Bone: elastic work0.20.30.50.40.7
Bone: endosteal estimation0.61.42.3-1.5-0.7
Bone: endosteal perimeter0.10.20.3-0.6-0.2
Epididymis fat weight0.41.52.90.2-1.7
Delta time in closed arm before/after self-admin0.80.71.21.10.6
Delta time in open arm before/after self-admin0.90.91.2-0.8-1.1
Diff in mean of infusions in LGA sessions0.00.00.00.00.2
Delay discount exponential model param0.30.30.40.50.6
Extinction: sum of active levers before priming0.10.10.2-0.00.4
Active lever presses in extinction session 60.80.80.8-0.9-0.9
Bone: final force0.10.20.2-0.4-0.5
Bone: final moment0.10.10.1-0.3-0.3
Food consumed during 24 hour testing period1.21.73.3-1.8-0.3
Glucose0.30.50.7-0.8-0.6
Heart weight0.61.01.41.20.8
Delay discount hyperbolic model param0.50.50.60.70.7
Intermittent access intake day 1-15 change0.40.91.10.81.0
Intermittent access intake escalation0.51.01.11.00.9
Intermittent access intake escalation 20.30.30.4-0.4-0.7
Intermitt. access day 1 inactive lever presses0.72.53.7-1.9-1.1
Intermitt. access day 15 inactive lever presses1.53.24.4-2.1-1.4
Intermitt. access escalation Index0.30.40.60.80.5
Intermittent access day 1 total infusions0.10.10.20.00.5
Intermittent access day 15 total infusions0.40.51.10.21.0
Intermittent access terminal intake (last 3 days)0.20.30.5-0.70.2
Intermittent access total infusions0.10.10.2-0.20.4
Intermittent access day 1 locomotion0.10.10.3-0.5-0.1
Intermittent access day 15 total locomotion0.10.10.2-0.10.5
Intermittent access total locomotion0.10.10.10.20.3
Intermittent access standard deviation0.30.60.9-1.0-0.6
Left kidney weight0.00.00.10.30.1
Right kidney weight0.10.51.0-0.3-1.0
Cocaine induced anxiety0.10.10.20.4-0.1
Post-drug Anxiety0.10.10.10.1-0.3
Baseline Anxiety0.40.40.7-0.40.8
Tail length0.20.81.3-1.1-0.6
Length with tail0.10.40.7-0.9-0.0
Length without tail0.10.20.2-0.40.5
Times rat made contact with spout0.30.40.6-0.4-0.7
Lifetime Intake0.10.10.10.30.4
Liver weight, left1.42.33.3-1.1-1.8
Liver weight, right1.52.63.2-1.8-1.4
Locomotor activity0.30.50.7-0.50.8
Locomotor testing distance0.40.81.60.11.3
Locomotor testing rearing0.10.30.60.10.8
Locomotion in novel chamber0.10.10.20.00.5
Locomotion in novel chamber post-restriction0.91.42.3-0.7-1.5
Fecal boli incidents, locomotor time 11.01.51.91.41.0
Change in fecal boli incidents, locomotor task0.20.20.30.6-0.1
Time >=10cm from walls, locomotor time 10.60.71.31.10.3
Bouts of movement, locomotor time 10.80.91.61.20.5
Total resting periods, locomotor time 10.50.51.01.00.4
Rest time, locomotor task time 10.40.50.7-0.60.9
Distance moved, locomotor task time 10.00.10.10.3-0.1
Vertical activity count, locomotor time 10.51.22.2-0.5-1.5
Time >=10cm from walls, locomotor time 20.00.10.10.30.2
Bouts of movement, locomotor time 20.10.20.3-0.3-0.6
Total resting periods, locomotor time 20.10.10.3-0.1-0.5
Rest time, locomotor task time 20.50.61.1-0.41.0
Distance moved, locomotor task time 20.40.51.01.00.2
Vertical activity count, locomotor time 20.50.71.5-0.2-1.2
Light reinforcement 10.51.31.7-1.3-1.0
Light reinforcement 20.00.00.0-0.10.0
Bone: marrow area0.61.22.0-1.4-0.6
Bone: maximum diameter0.20.30.6-0.2-0.7
Bone: maximum force0.10.20.3-0.6-0.4
Bone: maximum moment0.10.20.4-0.6-0.3
Mean time between licks in bursts1.74.36.72.61.3
Mean num. licks in bursts1.01.51.5-1.2-1.2
Cd content in liver3.43.85.32.31.5
Co content in liver0.20.20.30.40.5
Cu content in liver0.10.10.2-0.4-0.1
Fe content in liver0.20.20.40.6-0.3
K content in liver1.51.41.6-1.1-1.3
Mg content in liver0.60.60.7-0.8-0.8
Mn content in liver0.20.20.40.10.6
Na content in liver1.41.51.6-1.2-1.3
Rb content in liver0.91.01.31.10.9
Se content in liver0.10.10.1-0.3-0.4
Sr content in liver1.00.91.30.61.2
Zn content in liver0.20.30.40.40.6
Bone: minimum diameter4.78.611.0-3.3-2.5
Time in familiar zone, hab. session 10.20.20.2-0.40.4
Time in novel zone, hab. session 10.30.30.50.4-0.7
Total zone transitions, hab. session 10.30.40.4-0.6-0.6
Total locomotion distance, hab. session 11.01.42.5-1.6-0.6
Locomotion velocity, hab. session 10.70.91.8-1.3-0.3
Time in familiar zone, hab. session 20.10.10.2-0.10.5
Time in novel zone, hab. session 20.30.30.70.1-0.8
Total zone transitions, hab. session 20.00.00.00.00.2
Total locomotion distance, hab. session 20.30.40.7-0.8-0.2
Locomotion velocity, hab. session 20.30.40.7-0.8-0.1
Novel to familiar place preference ratio0.60.61.0-0.5-1.0
Novelty place preference0.50.50.9-0.3-0.9
Time in novel zone, NPP test0.90.91.5-0.6-1.2
Total zone transitions, NPP test0.10.10.1-0.3-0.4
Total locomotion distance, NPP test0.10.10.2-0.50.1
Locomotion velocity, NPP test0.10.10.2-0.10.4
Intraocular pressure0.30.50.70.90.4
Delta distance traveled before/after self-admin1.61.73.2-1.8-0.5
Delta ambulatory time before/after self-admin0.60.81.5-1.2-0.3
Parametrial fat weight1.63.74.3-2.1-1.8
Pavlov. Cond. lever latency0.81.11.31.10.9
Pavlov. Cond. magazine entry latency0.10.10.20.10.5
Pavlov. Cond. change in total contacts0.00.10.1-0.2-0.3
Pavlov. Cond. index score0.20.30.3-0.6-0.5
Pavlov. Cond. latency score0.20.30.4-0.7-0.4
Pavlov. Cond. lever contacts0.60.70.9-0.9-0.7
Pavlov. Cond. magazine entry number0.00.00.1-0.1-0.2
Pavlov. Cond. intertrial magazine entries0.50.60.8-0.6-0.9
Pavlov. Cond. lever-magazine prob. diff.0.30.30.4-0.6-0.5
Pavlov. Cond. response bias0.20.30.4-0.6-0.4
Pavlov. Cond. lever latency0.40.50.6-0.7-0.8
Pavlov. Cond. magazine entry latency1.21.51.81.11.3
Pavlov. Cond. change in total contacts0.50.91.10.81.0
Pavlov. Cond. index score0.91.31.41.11.2
Pavlov. Cond. latency score1.51.92.01.31.4
Pavlov. Cond. lever contacts0.10.10.20.30.4
Pavlov. Cond. magazine entry number2.12.62.8-1.5-1.7
Pavlov. Cond. intertrial magazine entries2.23.33.8-1.7-1.9
Pavlov. Cond. lever-magazine prob. diff.0.91.21.41.01.2
Pavlov. Cond. response bias0.60.81.00.81.0
Time in closed arm before self-admin0.10.10.1-0.4-0.0
Time in closed arm after self-admin0.90.91.00.91.0
Time in open arm before self-admin2.12.33.90.82.0
Time in open arm after self-admin1.92.12.5-1.3-1.6
Bone: periosteal estimation0.51.11.4-1.2-0.8
Bone: periosteal perimeter0.10.20.3-0.5-0.3
Bone: post-yield work0.10.10.1-0.2-0.4
Progressive ratio test 1 active lever presses0.20.20.30.30.6
Progressive ratio test 1 breakpoint0.10.20.30.20.5
Progressive ratio test 1 inactive lever presses2.13.13.9-2.0-1.5
Progressive ratio test 2 active lever presses0.00.00.10.10.3
Progressive ratio test 2 breakpoint0.10.10.10.10.3
Progressive ratio test 2 inactive lever presses0.71.21.5-1.2-0.9
Incentive Sensitization - Responses0.10.10.10.40.0
Incentive Sensitization - Breakpoint0.10.10.20.40.2
Sum of active levers in priming session hrs 5-60.20.20.2-0.4-0.5
Progressive ratio0.10.10.20.10.5
Food seeking constrained by brief footshock0.10.10.10.30.2
Seeking ratio, punishment vs. effort0.71.01.4-0.7-1.2
Retroperitoneal fat weight0.20.81.2-0.6-1.1
Reaction time number correct0.00.10.20.00.4
Reaction time mean minus median0.10.30.50.7-0.4
Reaction time mean minus median AUC0.20.40.60.4-0.8
Reaction time num false alarms0.81.22.1-0.5-1.4
Reaction time num false alarms AUC0.50.81.5-0.2-1.2
Reaction time trials correct on left0.00.10.20.00.4
Reaction time trials on left0.10.10.20.10.5
Reaction time mean0.40.71.21.1-0.5
Reaction time mean AUC0.40.60.90.9-0.5
Median of all reaction times0.50.71.21.1-0.4
Reaction time omissions1.11.61.81.31.2
Reaction time false alarm rate0.60.81.6-0.1-1.3
Reaction time premature initiation rate0.81.11.5-0.7-1.2
Reaction time premature initiations0.51.01.3-0.8-1.1
Std. dev. reaction times0.20.40.70.8-0.2
Reaction time trials completed0.10.10.20.10.5
Reaction time trials AUC0.10.10.20.20.4
Run reversals in cocaine runway, females1.31.32.5-1.6-0.4
Run reversals in cocaine runway, males0.60.61.10.31.1
Latency to leave start box in cocaine runway2.93.33.6-1.9-1.7
Latency to leave start box in cocaine runway, F4.55.16.3-2.5-2.0
Latency to leave start box in cocaine runway, M0.10.10.1-0.3-0.3
Std. dev. time between licks in bursts1.31.82.21.51.2
Total sessions with >9 infusions1.01.32.01.40.8
Short access day 1 total inactive lever presses0.40.50.7-0.8-0.6
Short access day 10 total inactive lever presses0.51.32.1-1.4-0.7
Short access day 1 total infusions0.30.40.5-0.5-0.7
Short access day 10 total infusions0.10.10.10.30.3
Short access total infusions0.20.20.40.70.2
Short access day 1 locomotion0.30.40.50.40.7
Short access day 10 total locomotion0.00.00.10.20.2
Short access total locomotion0.20.30.40.60.5
One hour access (0.3 mA shock)0.00.10.1-0.30.1
Compulsive drug intake0.91.01.3-0.8-1.2
One hour access (shock baseline)0.10.20.30.30.5
Social response proportion2.52.83.0-1.7-1.6
Social responses0.71.01.6-1.3-0.5
Social time0.40.61.0-1.0-0.5
Soleus weight0.72.22.51.41.6
Bone: stiffness1.11.82.0-1.3-1.4
Tibialis anterior weight2.68.913.13.62.2
Time to tail flick, vehicle, before self-admin0.50.50.9-0.9-0.4
Time to tail flick, vehicle, after self-admin0.40.50.8-0.50.9
Time to tail flick, test, before self-admin0.20.20.30.20.6
Time to tail flick, test, after self-admin0.80.81.0-1.0-0.8
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.20.3
Delta time to tail flick, test, before/after SA1.31.31.8-0.9-1.3
Tibia length0.10.30.4-0.4-0.6
Ambulatory time before self-admin0.00.00.0-0.20.2
Ambulatory time after self-admin2.12.54.5-2.1-0.7
Bone: tissue strength0.80.81.2-1.1-0.7
Total heroin consumption0.40.40.4-0.60.7
Bone: trabecular number0.30.50.9-0.3-0.9
Bone: trabecular spacing0.10.10.2-0.1-0.5
Bone: trabecular thickness0.10.10.3-0.5-0.1
Bone: trabecular tissue density0.20.30.50.70.3
Water consumed over 24 hours0.60.81.4-1.2-0.5
Number of responses in last shaping day0.20.20.40.2-0.6