Sult1b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Sult1b1	0.23	0.1	0.0e+00	0.15	0.14	0.14	0.1	4.2e-16	5.7e-15	7.1e-15	4.5e-11
2	Liver	isoform ratio	XM_039092392.1	0.07	0.04	3.4e-06	0.04	0.04	0.03	0.03	6.6e-05	2.8e-05	1.0e-04	2.8e-04
3	Liver	isoform ratio	XM_008770056.3	0.08	0.05	1.8e-05	0.03	0.04	0.03	0.03	5.3e-04	1.9e-05	6.7e-04	1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.2	0.5	-0.7	0.1	-0.0
Area under the delay curve	0.4	0.4	0.6	-0.1	0.8	-0.7
BMI with tail	1.7	5.6	7.0	-2.1	2.7	-2.4
BMI without tail	1.4	2.9	4.6	-0.1	2.0	-2.1
Body weight	0.7	2.7	3.9	-0.6	2.0	-2.0
Weight adjusted by age	0.7	0.8	1.9	-1.4	-0.5	0.6
Bone surface	0.4	0.8	1.2	-0.3	-1.0	1.1
Bone volume	0.1	0.2	0.3	0.2	-0.5	0.5
Breakpoint value in progressive ratio session	0.2	0.2	0.2	0.4	0.4	-0.5
Number of licking bursts	0.1	0.1	0.1	-0.3	0.2	-0.2
Context. condit. distance diff. score	4.0	4.8	7.3	0.2	-2.7	2.7
Locomotion velocity, session 1	2.2	2.4	3.6	-0.6	1.9	-1.8
Locomotion distance, session 1	0.2	0.3	0.4	0.6	-0.5	0.5
Locomotion velocity, session 2	0.2	0.2	0.3	0.3	-0.5	0.6
Locomotion distance, session 2	0.1	0.1	0.2	0.4	-0.2	0.2
Locomotion velocity, session 3	0.3	0.4	0.7	0.8	-0.5	0.4
Locomotion distance, session 3	0.1	0.1	0.2	0.1	-0.4	0.4
Stereotopy head waving bouts, day 3	0.8	1.0	1.1	-0.9	1.0	-1.0
Stereotopy head waving duration, day 3	0.2	0.2	0.3	-0.3	0.6	-0.6
Locomotion velocity, session 7	0.9	0.9	2.7	1.6	0.2	-0.4
Locomotion distance, session 7	0.7	0.8	1.7	1.3	-0.7	0.6
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	-0.7	-0.1	0.1
Stereotopy head waving duration, day 7	0.7	0.8	1.1	-0.6	1.1	-1.0
Locomotion velocity, session 8	0.8	1.0	1.6	-0.0	-1.1	1.3
Locomotion distance, session 8	3.3	4.8	7.0	0.8	-2.6	2.6
Degree of sensitization distance	0.6	0.6	1.1	1.1	-0.6	0.5
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.3	-0.3	0.4
Conditioned locomotion	0.5	0.6	1.0	-1.0	-0.4	0.7
Cocaine response after cond. corrected	0.4	0.4	1.1	1.1	-0.3	0.3
Cocaine response after cond. not corrected	0.7	0.7	0.9	1.0	-0.8	0.8
Cocaine response before conditioning	0.3	0.3	0.3	-0.5	-0.6	0.6
Saline control response	0.4	0.6	1.0	1.0	-0.6	0.5
Bone: connectivity density	0.3	0.5	0.8	-0.9	0.6	-0.5
Bone: cortical apparent density	3.3	4.3	6.5	0.2	2.5	-2.6
Bone: cortical area	0.2	0.3	0.3	0.6	0.4	-0.6
Bone: cortical porosity	0.8	0.9	2.2	-1.5	-0.3	0.6
Bone: cortical porosity	1.1	1.2	3.4	-1.9	0.3	-0.0
Bone: cortical thickness	0.3	0.5	0.7	-0.8	0.7	-0.7
Bone: cortical thickness	0.7	0.9	1.4	0.1	-1.2	1.1
Bone: cortical tissue density	3.3	4.3	6.6	0.1	2.5	-2.6
Condit. Reinf. active minus inactive responses	0.6	0.7	0.8	-0.8	0.9	-0.9
Condit. Reinf. active-inactive response ratio	1.1	1.2	3.5	-1.9	0.4	-0.3
Condit. Reinf. active responses	0.1	0.2	0.2	0.3	0.5	-0.5
Condit. Reinf. inactive responses	0.9	1.1	3.2	1.8	-0.3	0.1
Incentive salience index mean	0.2	0.2	0.3	-0.2	0.5	-0.5
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	-0.1	0.2
Condit. Reinf. active minus inactive responses	0.0	0.1	0.1	0.3	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	0.5	0.3	-0.4
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	-0.3	0.3
Condit. Reinf. inactive responses	0.8	0.9	1.4	0.5	-1.1	1.2
Condit. Reinf. lever presses	1.1	1.4	2.1	0.6	-1.5	1.4
Condit. Reinf. lever reinforcers received	0.3	0.5	0.7	0.3	-0.8	0.8
Conditioned reinforcement - actives	0.7	0.7	0.9	-0.5	-0.9	1.0
Conditioned reinforcement - inactives	1.1	1.2	1.7	1.3	-1.0	0.9
Conditioned locomotion	0.3	0.3	0.5	-0.0	-0.7	0.7
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.7	-0.0	0.0
Patch foraging indifference point AUC	1.3	1.5	3.6	1.9	0.5	-0.7
Delay disc. indifference point, 0s delay	0.5	0.6	0.9	-0.3	1.0	-0.9
Delay disc. indifference point, 16s delay	1.9	1.9	2.7	-0.8	1.6	-1.6
Delay disc. indifference point, 2s delay	1.0	1.1	3.2	1.8	-0.1	0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.5	-0.0	0.1
Delay disc. indifference point, 4s delay	1.0	1.0	1.4	0.6	1.1	-1.2
Delay disc. indifference point, 8s delay	1.3	1.3	1.5	-1.2	1.2	-1.0
Indifference point function ln k	0.5	0.7	1.4	-1.2	-0.6	0.6
Indifference point function log k	0.5	0.7	1.4	-1.2	-0.6	0.6
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	0.7	0.0	-0.1
Patch foraging total patch changes 12 sec	0.7	0.9	1.2	0.5	1.0	-1.1
Patch foraging total patch changes 18 sec	0.3	0.4	0.4	0.5	0.6	-0.7
Patch foraging total patch changes 24 sec	0.4	0.5	1.4	1.2	-0.3	0.3
Patch foraging total patch changes 6 sec	0.4	0.6	1.6	1.3	0.3	-0.5
Patch foraging time to switch 0 sec	1.8	2.7	5.7	-2.4	1.2	-0.9
Patch foraging water rate 0 sec	0.5	0.7	2.0	1.4	-0.4	0.2
Patch foraging water rate 12 sec	0.8	1.2	1.8	0.6	-1.3	1.3
Patch foraging water rate 18 sec	1.6	2.2	2.5	1.4	-1.6	1.4
Patch foraging water rate 24 sec	2.4	3.3	4.9	0.8	-2.2	2.1
Patch foraging water rate 6 sec	0.2	0.4	0.9	0.9	-0.4	0.2
Seeking ratio, delayed vs. immediate footshock	1.1	1.2	1.7	1.3	-1.1	0.9
Distance traveled before self-admin	0.3	0.3	0.6	0.8	-0.4	0.3
Distance traveled after self-admin	3.4	3.8	4.5	1.7	-2.1	2.0
Extensor digitorum longus weight	4.3	16.9	46.1	-6.8	1.9	-1.0
Bone: elastic displacement	1.4	1.6	2.4	-0.8	-1.4	1.5
Bone: elastic work	1.2	1.5	2.4	-0.5	-1.4	1.6
Bone: endosteal estimation	1.1	2.4	3.8	1.9	-1.4	1.2
Bone: endosteal perimeter	0.4	0.8	0.9	0.9	-0.9	0.7
Epididymis fat weight	0.6	1.5	2.3	-0.2	1.5	-1.5
Delta time in closed arm before/after self-admin	0.7	0.7	0.9	-0.9	0.8	-0.7
Delta time in open arm before/after self-admin	0.5	0.5	1.4	1.2	0.2	-0.3
Diff in mean of infusions in LGA sessions	0.2	0.2	0.3	-0.3	-0.5	0.5
Delay discount exponential model param	0.3	0.3	0.4	-0.1	-0.7	0.6
Extinction: sum of active levers before priming	0.7	0.7	0.8	0.8	-0.9	0.8
Active lever presses in extinction session 6	0.3	0.2	0.7	0.9	-0.1	-0.0
Bone: final force	0.1	0.1	0.2	0.2	0.3	-0.5
Bone: final moment	0.1	0.1	0.2	0.2	0.3	-0.5
Food consumed during 24 hour testing period	2.7	3.3	3.5	1.7	-1.9	1.9
Glucose	0.5	0.8	1.6	1.3	-0.7	0.5
Heart weight	0.3	0.4	1.0	-1.0	0.2	-0.2
Delay discount hyperbolic model param	0.3	0.3	0.4	-0.4	-0.6	0.6
Intermittent access intake day 1-15 change	1.4	1.4	2.2	-1.5	-0.9	1.1
Intermittent access intake escalation	1.3	1.3	1.7	-1.0	-1.1	1.3
Intermittent access intake escalation 2	0.4	0.4	0.7	-0.1	-0.8	0.8
Intermitt. access day 1 inactive lever presses	1.1	1.2	1.6	1.3	-1.0	1.0
Intermitt. access day 15 inactive lever presses	1.1	1.2	2.3	1.5	-0.9	0.8
Intermitt. access escalation Index	0.4	0.3	0.9	-1.0	-0.1	0.2
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.1	-0.4	0.4
Intermittent access day 15 total infusions	1.0	1.1	1.6	-0.1	-1.3	1.3
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.7	0.3	-1.3	1.2
Intermittent access total infusions	0.3	0.3	0.5	0.0	-0.7	0.6
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.1	-0.3	0.3
Intermittent access day 15 total locomotion	0.3	0.3	0.5	-0.2	-0.7	0.6
Intermittent access total locomotion	0.1	0.1	0.2	-0.4	0.0	-0.0
Intermittent access standard deviation	0.5	0.5	0.8	0.2	-0.9	0.9
Left kidney weight	0.2	0.6	1.0	0.6	-1.0	0.7
Right kidney weight	0.2	0.6	1.0	1.0	0.4	-0.7
Cocaine induced anxiety	0.1	0.2	0.2	-0.3	0.4	-0.4
Post-drug Anxiety	1.0	1.1	1.8	0.2	1.2	-1.3
Baseline Anxiety	0.4	0.4	0.6	0.3	-0.8	0.7
Tail length	0.0	0.1	0.2	0.4	-0.4	0.2
Length with tail	0.3	1.1	2.7	1.6	-0.7	0.4
Length without tail	0.2	0.4	1.2	1.1	-0.2	0.1
Times rat made contact with spout	0.3	0.3	0.4	0.6	0.6	-0.6
Lifetime Intake	0.2	0.2	0.3	-0.1	-0.5	0.5
Liver weight, left	1.0	1.5	3.2	1.8	0.8	-0.9
Liver weight, right	1.2	1.9	5.6	2.4	0.2	-0.3
Locomotor activity	1.1	1.7	2.3	0.8	-1.5	1.5
Locomotor testing distance	2.2	3.6	5.4	0.1	-2.3	2.3
Locomotor testing rearing	1.6	2.5	3.7	-0.4	-1.9	1.9
Locomotion in novel chamber	0.1	0.2	0.3	0.2	0.4	-0.5
Locomotion in novel chamber post-restriction	0.8	1.0	1.2	1.1	0.8	-1.1
Fecal boli incidents, locomotor time 1	0.7	0.8	1.9	-1.4	-0.5	0.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.2	-0.0	0.1
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.9	-1.4	0.0	0.1
Bouts of movement, locomotor time 1	0.7	0.8	1.0	-1.0	0.8	-0.9
Total resting periods, locomotor time 1	0.6	0.7	0.8	-0.8	0.8	-0.9
Rest time, locomotor task time 1	1.6	1.7	2.7	0.8	-1.6	1.4
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.4	0.6	-0.3
Vertical activity count, locomotor time 1	2.8	2.9	4.5	0.4	2.1	-2.0
Time >=10cm from walls, locomotor time 2	0.7	0.7	1.1	-0.5	-0.9	1.1
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.5	-0.1	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.4	0.0	-0.1
Rest time, locomotor task time 2	2.3	2.7	4.1	0.7	-2.0	1.9
Distance moved, locomotor task time 2	1.2	1.4	1.6	-1.2	1.3	-1.0
Vertical activity count, locomotor time 2	2.1	2.3	3.4	-0.1	1.9	-1.8
Light reinforcement 1	0.2	0.3	0.9	1.0	-0.1	-0.0
Light reinforcement 2	0.0	0.1	0.1	-0.1	0.3	-0.3
Bone: marrow area	1.1	2.4	3.5	1.9	-1.5	1.2
Bone: maximum diameter	0.5	0.9	1.6	0.0	1.1	-1.2
Bone: maximum force	0.1	0.1	0.3	0.6	-0.3	0.1
Bone: maximum moment	0.1	0.2	0.4	0.7	-0.3	0.0
Mean time between licks in bursts	2.7	3.8	6.9	-2.6	1.5	-1.4
Mean num. licks in bursts	0.3	0.3	0.9	1.0	0.1	-0.3
Cd content in liver	0.9	1.0	1.8	-1.3	0.8	-0.8
Co content in liver	0.1	0.1	0.3	0.5	0.2	-0.3
Cu content in liver	0.3	0.4	1.0	1.0	0.2	-0.3
Fe content in liver	1.6	1.9	2.9	-0.5	1.7	-1.6
K content in liver	2.1	2.1	2.4	1.6	1.3	-1.4
Mg content in liver	2.6	2.7	3.3	1.4	1.7	-1.8
Mn content in liver	0.0	0.0	0.1	-0.2	0.0	0.0
Na content in liver	1.8	1.9	2.2	1.2	1.4	-1.5
Rb content in liver	1.1	1.3	1.5	-1.1	1.2	-1.2
Se content in liver	0.1	0.1	0.2	0.2	0.4	-0.4
Sr content in liver	1.4	1.2	1.6	-0.8	-1.2	1.2
Zn content in liver	0.5	0.5	1.1	1.1	-0.4	0.5
Bone: minimum diameter	2.2	4.2	11.6	3.4	-0.9	0.4
Time in familiar zone, hab. session 1	1.1	1.1	1.6	0.6	-1.1	1.3
Time in novel zone, hab. session 1	3.3	3.2	4.7	-0.8	2.0	-2.2
Total zone transitions, hab. session 1	0.1	0.2	0.5	0.7	-0.1	0.1
Total locomotion distance, hab. session 1	1.9	2.6	2.9	1.7	-1.6	1.5
Locomotion velocity, hab. session 1	2.1	3.0	3.4	1.5	-1.9	1.8
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.1	-0.2	0.3
Time in novel zone, hab. session 2	1.8	1.8	2.8	-0.4	1.5	-1.7
Total zone transitions, hab. session 2	0.3	0.4	0.7	0.2	-0.8	0.7
Total locomotion distance, hab. session 2	0.9	1.2	1.7	0.9	-1.3	1.1
Locomotion velocity, hab. session 2	1.2	1.6	2.1	0.9	-1.5	1.3
Novel to familiar place preference ratio	1.9	1.9	3.0	0.3	1.6	-1.7
Novelty place preference	2.8	2.8	4.5	0.1	2.0	-2.1
Time in novel zone, NPP test	3.1	3.2	5.1	0.3	2.1	-2.2
Total zone transitions, NPP test	0.0	0.1	0.1	0.3	0.2	-0.2
Total locomotion distance, NPP test	0.7	1.0	1.4	0.5	-1.2	1.2
Locomotion velocity, NPP test	0.7	1.0	1.5	0.2	-1.2	1.2
Intraocular pressure	0.7	0.9	1.0	-0.9	1.0	-1.0
Delta distance traveled before/after self-admin	0.6	0.7	0.9	0.5	-0.9	0.9
Delta ambulatory time before/after self-admin	0.4	0.5	0.7	0.2	-0.8	0.8
Parametrial fat weight	1.0	2.0	4.0	2.0	0.9	-1.1
Pavlov. Cond. lever latency	0.3	0.4	0.9	-0.9	-0.4	0.4
Pavlov. Cond. magazine entry latency	0.4	0.5	0.9	0.2	-0.8	0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.2	0.3	-0.4
Pavlov. Cond. index score	0.1	0.1	0.3	0.5	0.2	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.4	0.6	0.1	-0.1
Pavlov. Cond. lever contacts	0.3	0.4	1.0	1.0	0.2	-0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.3	-0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.7	0.6	1.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.6	0.1	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.4	0.6	0.1	-0.0
Pavlov. Cond. lever latency	0.9	1.2	1.7	0.4	1.3	-1.3
Pavlov. Cond. magazine entry latency	0.7	0.8	1.0	-1.0	-0.8	0.9
Pavlov. Cond. change in total contacts	1.2	1.6	2.2	-0.8	-1.4	1.5
Pavlov. Cond. index score	1.5	2.0	2.7	-0.9	-1.5	1.6
Pavlov. Cond. latency score	1.8	2.3	3.0	-1.1	-1.6	1.7
Pavlov. Cond. lever contacts	1.3	1.8	2.8	-0.2	-1.6	1.7
Pavlov. Cond. magazine entry number	1.4	1.7	2.2	1.5	1.1	-1.2
Pavlov. Cond. intertrial magazine entries	1.2	1.5	2.8	1.7	0.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.7	-0.8	-1.5	1.6
Pavlov. Cond. response bias	1.4	2.0	2.8	-0.8	-1.6	1.7
Time in closed arm before self-admin	0.4	0.4	0.8	0.9	-0.5	0.4
Time in closed arm after self-admin	0.5	0.5	0.7	-0.4	-0.8	0.8
Time in open arm before self-admin	1.2	1.3	1.7	-1.3	-0.9	1.1
Time in open arm after self-admin	0.7	0.8	1.3	1.1	0.8	-0.8
Bone: periosteal estimation	0.3	0.7	1.7	1.3	-0.5	0.3
Bone: periosteal perimeter	0.2	0.3	0.5	0.7	-0.5	0.3
Bone: post-yield work	0.2	0.3	0.3	0.6	0.4	-0.6
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.0	-0.0	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.2	-0.1	0.0
Progressive ratio test 1 inactive lever presses	1.4	1.5	3.8	1.9	-0.7	0.6
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.2	-0.1	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.1	0.0	-0.2
Progressive ratio test 2 inactive lever presses	1.0	1.1	1.7	1.3	-1.0	0.8
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.2	0.0	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.1	-0.2	0.1
Sum of active levers in priming session hrs 5-6	1.0	0.9	1.0	0.9	-1.0	1.0
Progressive ratio	0.4	0.5	1.0	-1.0	-0.5	0.6
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.4	0.1	-0.1
Seeking ratio, punishment vs. effort	0.5	0.6	1.0	1.0	0.6	-0.6
Retroperitoneal fat weight	1.3	4.3	6.5	0.9	2.4	-2.5
Reaction time number correct	0.1	0.1	0.2	-0.5	-0.3	0.3
Reaction time mean minus median	1.4	1.8	2.6	-0.6	1.6	-1.6
Reaction time mean minus median AUC	2.8	3.6	5.3	-0.6	2.3	-2.3
Reaction time num false alarms	1.0	1.3	1.9	0.6	1.3	-1.4
Reaction time num false alarms AUC	1.1	1.5	2.3	0.2	1.5	-1.5
Reaction time trials correct on left	0.1	0.1	0.2	-0.5	-0.3	0.3
Reaction time trials on left	0.1	0.2	0.3	-0.6	-0.3	0.3
Reaction time mean	1.0	1.3	1.8	-0.8	1.3	-1.3
Reaction time mean AUC	1.1	1.5	2.0	-0.6	1.4	-1.4
Median of all reaction times	0.7	1.0	1.3	-0.7	1.1	-1.1
Reaction time omissions	0.8	1.1	2.1	-1.5	0.8	-0.7
Reaction time false alarm rate	1.1	1.5	2.1	0.5	1.5	-1.5
Reaction time premature initiation rate	0.1	0.2	0.2	0.4	0.3	-0.5
Reaction time premature initiations	0.1	0.2	0.3	0.3	0.4	-0.6
Std. dev. reaction times	0.9	1.3	1.8	-0.6	1.3	-1.3
Reaction time trials completed	0.1	0.2	0.3	-0.6	-0.3	0.3
Reaction time trials AUC	0.1	0.1	0.4	-0.6	-0.1	0.0
Run reversals in cocaine runway, females	1.5	1.5	2.7	1.6	-1.0	0.9
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.5	-0.0	0.2
Latency to leave start box in cocaine runway	1.1	1.2	3.6	1.9	-0.1	-0.2
Latency to leave start box in cocaine runway, F	1.9	2.0	5.9	2.4	-0.0	-0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	-0.2	0.2
Std. dev. time between licks in bursts	0.4	0.5	1.1	-1.1	-0.2	0.4
Total sessions with >9 infusions	0.9	1.0	2.2	-1.5	-0.5	0.7
Short access day 1 total inactive lever presses	2.8	3.1	4.1	1.2	-2.0	2.0
Short access day 10 total inactive lever presses	2.0	2.3	2.7	1.2	-1.6	1.6
Short access day 1 total infusions	0.1	0.1	0.4	0.6	-0.0	-0.0
Short access day 10 total infusions	0.2	0.2	0.3	-0.1	-0.6	0.6
Short access total infusions	0.1	0.1	0.2	-0.4	-0.0	0.1
Short access day 1 locomotion	0.0	0.0	0.0	-0.2	0.1	-0.0
Short access day 10 total locomotion	0.4	0.4	0.6	-0.4	0.7	-0.8
Short access total locomotion	0.2	0.2	0.5	-0.7	0.3	-0.2
One hour access (0.3 mA shock)	0.3	0.4	0.6	0.3	-0.8	0.6
Compulsive drug intake	0.6	0.6	0.6	0.7	0.7	-0.8
One hour access (shock baseline)	0.1	0.1	0.2	-0.2	-0.5	0.4
Social response proportion	1.0	1.1	2.2	1.5	0.7	-0.8
Social responses	0.2	0.3	0.6	0.8	0.3	-0.4
Social time	0.4	0.5	1.1	1.1	0.3	-0.5
Soleus weight	0.9	2.6	4.1	-0.9	-1.8	2.0
Bone: stiffness	1.1	1.7	2.1	1.3	1.2	-1.5
Tibialis anterior weight	2.1	7.2	15.0	-3.9	2.0	-1.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.8	-0.1	-0.0
Time to tail flick, vehicle, after self-admin	2.7	2.9	4.2	0.6	-2.0	2.1
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.0	-0.4	0.6
Time to tail flick, test, after self-admin	0.7	0.7	2.0	1.4	-0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	0.1	-0.6	0.6
Delta time to tail flick, test, before/after SA	0.8	0.8	1.1	1.0	0.7	-0.9
Tibia length	0.1	0.2	0.3	0.5	0.3	-0.6
Ambulatory time before self-admin	0.3	0.3	0.6	0.8	-0.4	0.3
Ambulatory time after self-admin	2.6	2.9	3.2	1.8	-1.7	1.5
Bone: tissue strength	0.3	0.3	0.9	0.9	0.2	-0.3
Total heroin consumption	1.1	1.3	2.6	1.6	-0.9	0.8
Bone: trabecular number	0.3	0.5	0.8	-0.4	0.9	-0.8
Bone: trabecular spacing	1.1	1.4	2.2	-0.1	1.4	-1.5
Bone: trabecular thickness	0.4	0.5	0.7	0.3	-0.9	0.8
Bone: trabecular tissue density	0.9	1.3	1.9	-0.5	1.3	-1.4
Water consumed over 24 hours	0.8	1.0	2.3	1.5	-0.6	0.5
Number of responses in last shaping day	0.2	0.2	0.3	-0.5	0.5	-0.3