Hub : Genes

Stk17b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative TSS	XM_039082991.2	0.02	0.02	5.4e-03	0.03	0.02	0.02	0.03	3.6e-04	4.4e-03	6.9e-03	1.3e-03
2	Adipose	gene expression	Stk17b	0.03	0.03	2.6e-04	0.01	0.01	0.01	0.01	1.2e-02	6.7e-03	5.8e-02	1.8e-02
3	Brain	isoform ratio	XM_039082991.2	0.03	0.02	4.4e-03	0.02	0.02	0.01	0.01	5.9e-03	8.4e-03	3.8e-02	1.7e-02
4	IC	alternative TSS	XM_039082990.2	0.18	0.1	2.9e-03	0.03	0.05	0.03	0.04	2.0e-02	4.6e-03	1.8e-02	8.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	3.2	5.5	8.6	-2.9	2.6	-2.6	-0.1
Area under the delay curve	0.6	0.7	1.0	0.9	-1.0	0.9	0.2
BMI with tail	3.3	11.5	14.4	3.5	-3.8	3.6	-2.6
BMI without tail	0.3	1.0	2.2	0.8	-0.9	0.6	-1.5
Body weight	1.5	6.4	9.7	-3.1	3.0	-2.6	-0.5
Weight adjusted by age	0.7	1.1	2.0	-1.2	0.9	-0.3	1.4
Bone surface	3.1	5.7	10.1	-3.2	2.5	-2.6	-0.1
Bone volume	3.3	6.0	10.6	-3.2	2.6	-2.6	0.1
Breakpoint value in progressive ratio session	0.5	0.7	1.7	-0.4	0.9	-1.3	0.1
Number of licking bursts	0.1	0.2	0.4	0.4	-0.6	0.7	0.1
Context. condit. distance diff. score	1.5	1.9	2.7	1.0	-1.5	1.3	-1.6
Locomotion velocity, session 1	2.4	2.6	4.4	2.1	-1.7	1.8	0.3
Locomotion distance, session 1	0.9	1.2	1.9	1.4	-1.0	0.6	-1.3
Locomotion velocity, session 2	2.9	3.3	5.6	2.4	-2.0	1.8	-0.5
Locomotion distance, session 2	0.2	0.2	0.6	0.8	-0.3	0.1	-0.4
Locomotion velocity, session 3	0.6	0.6	1.9	-0.3	0.4	-0.6	-1.4
Locomotion distance, session 3	0.0	0.0	0.1	-0.3	0.1	0.0	-0.1
Stereotopy head waving bouts, day 3	0.5	0.5	0.9	0.9	-0.8	0.7	-0.5
Stereotopy head waving duration, day 3	0.3	0.3	0.9	0.6	-0.2	0.1	-1.0
Locomotion velocity, session 7	3.2	3.5	4.8	2.1	-2.2	2.1	-0.4
Locomotion distance, session 7	0.2	0.3	0.4	0.5	-0.7	0.3	-0.6
Stereotopy head waving bouts, day 7	0.4	0.4	0.6	0.8	-0.3	0.6	0.7
Stereotopy head waving duration, day 7	0.2	0.2	0.4	0.6	-0.3	0.6	-0.1
Locomotion velocity, session 8	2.7	3.2	5.3	1.9	-2.0	2.3	0.1
Locomotion distance, session 8	1.3	1.9	2.4	1.4	-1.4	1.1	-1.5
Degree of sensitization distance	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.0
Degree of sensitization stereotypy	0.2	0.2	0.4	0.6	-0.1	0.5	0.6
Conditioned locomotion	3.3	3.8	5.1	-2.1	2.3	-2.1	1.1
Cocaine response after cond. corrected	1.9	2.2	6.1	-1.0	1.1	-0.8	2.5
Cocaine response after cond. not corrected	1.8	2.2	5.1	-1.2	1.1	-0.9	2.2
Cocaine response before conditioning	0.2	0.2	0.5	0.1	-0.5	0.4	-0.7
Saline control response	0.4	0.6	2.0	-0.1	0.0	-0.6	-1.4
Bone: connectivity density	1.2	1.9	3.5	-1.9	1.4	-1.5	0.0
Bone: cortical apparent density	5.0	6.8	8.7	2.8	-2.9	2.5	-2.1
Bone: cortical area	0.1	0.2	0.3	-0.5	0.5	-0.4	-0.2
Bone: cortical porosity	2.9	3.1	4.3	-2.1	2.0	-1.9	0.7
Bone: cortical porosity	5.2	5.6	8.3	-2.9	2.7	-2.5	0.6
Bone: cortical thickness	0.8	1.3	1.9	1.3	-1.1	1.4	-0.6
Bone: cortical thickness	2.2	2.5	3.8	1.7	-1.5	1.9	1.1
Bone: cortical tissue density	4.9	6.7	8.5	2.7	-2.9	2.4	-2.1
Condit. Reinf. active minus inactive responses	1.0	1.1	2.3	-0.6	0.9	-1.1	1.5
Condit. Reinf. active-inactive response ratio	0.7	0.7	2.1	-0.2	0.4	-0.7	1.5
Condit. Reinf. active responses	1.1	1.3	1.8	-0.9	1.1	-1.1	1.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.5	-0.3	-0.0
Incentive salience index mean	0.9	1.1	2.9	-0.4	0.8	-0.9	1.7
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.3	0.6	-0.6	0.7
Condit. Reinf. active minus inactive responses	2.9	3.7	7.1	-1.1	2.0	-1.6	2.7
Condit. Reinf. active-inactive response ratio	2.5	2.8	9.4	-0.6	1.1	-0.5	3.1
Condit. Reinf. active responses	0.9	1.3	2.7	-0.7	1.1	-0.9	1.6
Condit. Reinf. inactive responses	0.4	0.5	1.4	0.5	-0.6	0.4	-1.2
Condit. Reinf. lever presses	0.6	0.8	1.2	1.1	-0.9	0.9	0.7
Condit. Reinf. lever reinforcers received	0.9	1.2	3.1	-0.6	1.0	-0.7	1.7
Conditioned reinforcement - actives	0.6	1.1	3.1	-0.1	0.3	-1.0	-1.8
Conditioned reinforcement - inactives	0.1	0.1	0.3	-0.1	0.1	-0.6	-0.3
Conditioned locomotion	0.9	1.1	4.2	-0.0	-0.1	-0.6	-2.0
Patch foraging indifference point 0 sec	0.8	1.6	2.6	1.3	-1.6	1.4	0.3
Patch foraging indifference point AUC	0.0	0.1	0.2	-0.4	0.1	-0.2	0.3
Delay disc. indifference point, 0s delay	1.8	1.9	3.0	1.6	-1.7	1.2	-0.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.4	-0.5	0.5	0.3
Delay disc. indifference point, 2s delay	0.7	0.8	0.9	0.8	-0.9	0.9	0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.4	-0.5	0.4	-0.1
Delay disc. indifference point, 4s delay	1.8	1.9	2.8	1.4	-1.7	1.6	-0.6
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.0	-0.1	0.1	0.5
Indifference point function ln k	1.0	1.8	2.6	1.5	-1.3	1.6	0.7
Indifference point function log k	1.0	1.8	2.6	1.5	-1.3	1.6	0.7
Patch foraging total patch changes 0 sec	0.8	1.4	2.3	1.3	-1.5	1.3	0.2
Patch foraging total patch changes 12 sec	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.0
Patch foraging total patch changes 18 sec	1.6	2.4	3.9	1.8	-2.0	1.5	0.0
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.0	-0.3	-0.0	-0.5
Patch foraging total patch changes 6 sec	0.9	1.3	2.3	0.9	-1.5	1.4	0.1
Patch foraging time to switch 0 sec	0.2	0.5	0.7	-0.6	0.5	-0.8	-0.8
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.3	-0.0	0.1	0.2
Patch foraging water rate 12 sec	0.7	1.5	2.1	1.3	-1.0	1.5	1.1
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.5	0.3	0.1	0.5
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.1	0.4	-0.4	0.1
Patch foraging water rate 6 sec	0.1	0.2	0.4	0.4	-0.4	0.6	-0.4
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	2.3	-0.7	1.5	-1.4	1.0
Distance traveled before self-admin	1.6	2.0	3.9	-0.9	2.0	-1.7	0.8
Distance traveled after self-admin	0.4	0.5	1.2	1.1	0.0	-0.0	0.8
Extensor digitorum longus weight	2.1	8.4	9.4	2.7	-3.1	2.7	-3.1
Bone: elastic displacement	0.5	0.6	1.9	-0.6	-0.1	0.4	1.4
Bone: elastic work	1.8	2.3	5.0	-2.2	1.4	-1.4	0.5
Bone: endosteal estimation	3.9	8.6	12.4	-3.5	3.1	-3.3	1.0
Bone: endosteal perimeter	2.9	6.2	9.4	-3.1	2.6	-2.8	0.9
Epididymis fat weight	0.6	2.2	3.4	-1.6	1.9	-1.5	-0.5
Delta time in closed arm before/after self-admin	0.7	0.6	1.8	1.3	-0.6	0.7	0.1
Delta time in open arm before/after self-admin	5.7	5.6	6.6	-2.6	2.4	-2.0	2.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	0.4	-0.1	-0.3	0.2
Delay discount exponential model param	0.5	0.6	0.8	-0.8	0.9	-0.8	-0.4
Extinction: sum of active levers before priming	0.9	1.0	1.5	-0.9	1.2	-1.2	-0.4
Active lever presses in extinction session 6	1.8	1.8	2.8	-1.7	1.3	-1.7	0.2
Bone: final force	2.9	4.7	7.0	-2.2	2.5	-2.6	-0.7
Bone: final moment	2.6	4.1	5.7	-2.1	2.3	-2.4	-0.9
Food consumed during 24 hour testing period	0.7	1.0	3.8	-0.4	0.2	-0.4	-1.9
Glucose	0.9	1.4	5.5	0.1	0.1	-0.3	-2.4
Heart weight	0.3	0.5	1.7	0.3	0.1	0.6	1.3
Delay discount hyperbolic model param	0.5	0.6	0.8	-0.8	0.9	-0.9	-0.4
Intermittent access intake day 1-15 change	0.6	1.2	3.1	0.2	-0.8	0.9	-1.8
Intermittent access intake escalation	0.7	1.5	3.0	0.5	-1.1	1.2	-1.7
Intermittent access intake escalation 2	0.4	0.4	1.1	-0.6	0.1	0.4	-1.0
Intermitt. access day 1 inactive lever presses	0.9	3.4	7.0	1.8	-1.6	0.8	-2.6
Intermitt. access day 15 inactive lever presses	0.3	0.7	1.5	-0.1	-1.1	1.2	-0.4
Intermitt. access escalation Index	0.4	0.5	1.4	-1.2	0.8	0.1	-0.4
Intermittent access day 1 total infusions	1.7	2.7	5.5	-1.6	1.5	-2.3	-0.6
Intermittent access day 15 total infusions	0.7	1.1	3.7	-0.4	0.1	-0.7	-1.9
Intermittent access terminal intake (last 3 days)	0.9	1.2	4.2	-0.5	0.1	-0.6	-2.1
Intermittent access total infusions	1.4	1.6	2.9	-1.1	0.9	-1.7	-1.3
Intermittent access day 1 locomotion	0.5	0.7	1.6	-0.5	0.5	-1.3	-0.7
Intermittent access day 15 total locomotion	0.5	1.0	3.0	-0.7	0.2	-0.6	-1.7
Intermittent access total locomotion	0.8	0.9	3.2	-0.2	0.0	-0.6	-1.8
Intermittent access standard deviation	0.3	0.7	2.6	-0.3	-0.2	-0.0	-1.6
Left kidney weight	0.1	0.5	1.4	-1.2	0.6	-0.0	0.6
Right kidney weight	0.1	0.4	1.4	-1.2	0.2	0.4	0.2
Cocaine induced anxiety	0.6	0.9	1.4	0.8	-0.9	1.2	0.9
Post-drug Anxiety	1.0	1.1	2.3	0.9	-1.1	1.5	0.2
Baseline Anxiety	0.1	0.1	0.2	-0.4	0.2	0.0	-0.3
Tail length	8.7	33.9	46.4	-6.6	6.8	-6.5	1.9
Length with tail	10.4	45.2	62.5	-7.9	7.9	-7.3	1.8
Length without tail	3.9	12.7	21.4	-4.6	4.2	-3.3	0.9
Times rat made contact with spout	0.6	0.6	1.5	-0.4	0.4	-0.9	-1.2
Lifetime Intake	1.1	1.3	2.3	-0.8	0.6	-1.4	-1.5
Liver weight, left	3.1	5.1	7.4	-2.7	2.6	-2.2	-1.0
Liver weight, right	1.3	2.3	3.3	-1.8	1.7	-1.4	1.0
Locomotor activity	0.2	0.2	0.6	-0.3	-0.2	0.4	-0.8
Locomotor testing distance	0.2	0.3	0.6	-0.6	-0.4	0.8	-0.3
Locomotor testing rearing	0.3	0.6	1.3	-1.1	-0.1	0.3	-1.1
Locomotion in novel chamber	1.3	1.7	2.5	1.3	-1.5	1.6	-0.6
Locomotion in novel chamber post-restriction	0.3	0.5	0.7	0.8	-0.9	0.8	-0.3
Fecal boli incidents, locomotor time 1	0.2	0.3	0.8	-0.5	0.3	0.1	0.9
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	1.0	-0.1	0.3	0.6
Time >=10cm from walls, locomotor time 1	3.1	3.3	9.3	1.3	-0.8	1.1	3.1
Bouts of movement, locomotor time 1	0.1	0.1	0.4	0.0	-0.2	0.1	0.6
Total resting periods, locomotor time 1	0.4	0.4	0.8	0.5	-0.9	0.6	0.5
Rest time, locomotor task time 1	0.5	0.6	1.0	-0.9	0.4	-1.0	-0.5
Distance moved, locomotor task time 1	0.3	0.5	1.8	0.1	-0.0	0.4	1.3
Vertical activity count, locomotor time 1	0.1	0.3	0.6	0.6	-0.6	0.8	0.1
Time >=10cm from walls, locomotor time 2	1.5	2.2	7.3	-0.6	0.8	-0.7	2.7
Bouts of movement, locomotor time 2	0.9	1.5	2.5	1.3	-1.6	1.3	-0.4
Total resting periods, locomotor time 2	0.9	1.5	2.6	1.2	-1.6	1.4	-0.5
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.3	-0.2	-0.2	-0.6
Distance moved, locomotor task time 2	0.5	0.5	2.0	-0.2	0.1	0.3	1.4
Vertical activity count, locomotor time 2	0.2	0.3	0.7	0.8	-0.6	0.4	-0.2
Light reinforcement 1	1.0	2.3	8.8	-0.0	-0.7	0.4	-3.0
Light reinforcement 2	0.6	1.0	1.7	-0.9	1.0	-1.3	-0.4
Bone: marrow area	3.7	8.0	11.4	-3.4	3.0	-3.2	1.0
Bone: maximum diameter	0.4	0.7	0.9	-0.9	0.8	-0.9	0.8
Bone: maximum force	4.3	7.7	11.1	-3.3	3.1	-3.2	-0.3
Bone: maximum moment	3.8	6.6	10.2	-3.2	2.8	-2.9	-0.5
Mean time between licks in bursts	0.3	0.8	2.4	0.5	-0.6	0.3	-1.6
Mean num. licks in bursts	0.3	0.5	0.8	-0.6	0.5	-0.9	-0.7
Cd content in liver	0.7	0.7	1.0	-0.9	0.9	-1.0	-0.6
Co content in liver	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1
Cu content in liver	0.4	0.5	0.6	-0.8	0.7	-0.7	0.5
Fe content in liver	1.1	1.4	2.3	-1.3	1.3	-1.5	-0.1
K content in liver	0.3	0.3	0.9	0.1	-0.3	0.4	0.9
Mg content in liver	0.2	0.2	0.8	0.2	0.0	0.2	0.9
Mn content in liver	2.2	2.5	3.3	1.8	-1.8	1.8	-0.4
Na content in liver	0.1	0.1	0.3	-0.5	0.2	0.0	0.4
Rb content in liver	0.8	1.0	1.7	1.1	-1.0	1.3	0.1
Se content in liver	0.0	0.0	0.1	0.0	0.2	-0.2	-0.0
Sr content in liver	3.8	3.3	5.7	-2.4	1.7	-1.9	-0.9
Zn content in liver	0.7	0.8	1.1	-1.0	0.9	-1.1	-0.3
Bone: minimum diameter	0.8	1.5	2.0	-1.4	1.3	-1.4	0.5
Time in familiar zone, hab. session 1	0.7	0.7	1.2	0.9	-0.6	0.5	-1.1
Time in novel zone, hab. session 1	1.5	1.5	4.1	-0.9	0.8	-0.6	2.0
Total zone transitions, hab. session 1	0.6	0.9	1.2	0.8	-0.7	1.1	1.0
Total locomotion distance, hab. session 1	0.6	0.9	2.5	-0.6	0.6	-0.5	1.6
Locomotion velocity, hab. session 1	0.7	1.0	1.1	-1.0	1.1	-1.1	0.9
Time in familiar zone, hab. session 2	0.5	0.6	1.1	1.1	-0.6	0.6	0.7
Time in novel zone, hab. session 2	0.7	0.7	1.4	-1.2	0.7	-0.8	-0.2
Total zone transitions, hab. session 2	0.1	0.2	0.5	0.3	0.2	-0.3	-0.7
Total locomotion distance, hab. session 2	1.5	2.0	4.0	-1.2	1.5	-2.0	-0.3
Locomotion velocity, hab. session 2	1.5	2.0	3.7	-1.3	1.4	-1.9	-0.6
Novel to familiar place preference ratio	5.6	6.2	8.3	-2.9	2.7	-2.9	0.9
Novelty place preference	5.5	5.9	8.0	-2.8	2.6	-2.8	0.9
Time in novel zone, NPP test	5.4	5.7	7.4	-2.7	2.6	-2.7	1.2
Total zone transitions, NPP test	0.2	0.3	0.6	0.8	-0.4	0.5	-0.4
Total locomotion distance, NPP test	0.3	0.4	0.6	-0.3	0.6	-0.7	0.8
Locomotion velocity, NPP test	0.1	0.2	0.3	-0.4	0.4	-0.6	0.0
Intraocular pressure	1.1	1.6	2.6	1.3	-1.6	1.4	-0.3
Delta distance traveled before/after self-admin	0.7	0.7	1.1	1.0	-1.1	0.8	-0.4
Delta ambulatory time before/after self-admin	0.4	0.5	0.7	0.5	-0.8	0.6	-0.9
Parametrial fat weight	0.2	0.4	1.6	0.0	-0.1	0.2	-1.2
Pavlov. Cond. lever latency	0.6	0.8	1.3	1.0	-0.8	0.5	-1.1
Pavlov. Cond. magazine entry latency	1.2	1.5	5.3	-0.5	0.6	-0.2	2.3
Pavlov. Cond. change in total contacts	0.6	0.7	2.6	-0.1	0.0	-0.1	1.6
Pavlov. Cond. index score	0.9	1.1	2.5	-0.8	0.9	-0.6	1.6
Pavlov. Cond. latency score	1.0	1.2	2.7	-0.9	0.9	-0.6	1.6
Pavlov. Cond. lever contacts	0.5	0.6	1.0	-0.8	0.6	-0.4	1.0
Pavlov. Cond. magazine entry number	1.1	1.4	3.4	0.9	-1.0	0.7	-1.8
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.7	-0.5	1.1	-1.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.7	-0.6	0.6	-0.3	1.6
Pavlov. Cond. response bias	0.8	1.0	2.8	-0.7	0.8	-0.5	1.7
Pavlov. Cond. lever latency	0.9	1.2	1.9	-1.4	1.2	-1.1	-0.5
Pavlov. Cond. magazine entry latency	0.4	0.5	0.9	0.9	-0.7	0.6	-0.4
Pavlov. Cond. change in total contacts	0.9	1.5	3.6	1.0	-0.6	1.0	1.9
Pavlov. Cond. index score	0.5	0.7	1.2	1.1	-0.8	0.8	0.5
Pavlov. Cond. latency score	0.4	0.5	1.0	1.0	-0.7	0.7	0.4
Pavlov. Cond. lever contacts	0.8	1.2	1.6	1.3	-1.1	1.0	0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	0.4	-0.5	0.3	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.4	1.2	-0.9	1.0	0.6
Pavlov. Cond. response bias	0.3	0.4	0.5	0.7	-0.6	0.6	0.7
Time in closed arm before self-admin	2.1	2.7	5.6	-2.4	1.7	-1.2	0.8
Time in closed arm after self-admin	0.4	0.4	1.2	-0.0	-0.2	0.6	1.1
Time in open arm before self-admin	4.6	5.0	7.5	2.7	-1.8	1.4	-2.7
Time in open arm after self-admin	0.9	1.0	1.5	-0.5	1.1	-1.0	1.2
Bone: periosteal estimation	2.5	5.3	7.3	-2.7	2.5	-2.6	0.9
Bone: periosteal perimeter	2.1	3.5	4.7	-2.1	2.0	-2.2	0.9
Bone: post-yield work	1.4	2.0	2.8	-1.6	1.5	-1.7	-0.6
Progressive ratio test 1 active lever presses	0.2	0.2	0.5	-0.1	-0.1	-0.7	-0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.7	-0.3	0.1	-0.8	-0.3
Progressive ratio test 1 inactive lever presses	1.7	2.5	8.6	0.7	-0.9	-0.0	-2.9
Progressive ratio test 2 active lever presses	0.4	0.5	0.7	-0.4	0.5	-0.9	-0.8
Progressive ratio test 2 breakpoint	0.4	0.4	0.6	-0.4	0.4	-0.8	-0.8
Progressive ratio test 2 inactive lever presses	0.5	0.9	1.9	-0.9	0.3	-0.8	-1.4
Incentive Sensitization - Responses	0.3	0.4	0.6	-0.7	0.8	-0.7	0.2
Incentive Sensitization - Breakpoint	0.3	0.4	0.6	-0.6	0.8	-0.7	0.0
Sum of active levers in priming session hrs 5-6	2.8	2.6	4.5	-1.6	1.8	-2.1	0.1
Progressive ratio	0.5	0.8	2.3	1.5	-0.7	0.5	0.2
Food seeking constrained by brief footshock	0.3	0.4	1.1	0.5	-0.1	0.5	1.0
Seeking ratio, punishment vs. effort	0.5	0.8	1.8	-1.4	0.8	-0.4	0.6
Retroperitoneal fat weight	0.7	3.0	9.3	-1.1	0.9	-0.9	-3.1
Reaction time number correct	0.3	0.5	0.8	0.7	-0.9	0.8	-0.5
Reaction time mean minus median	1.8	4.5	6.3	-2.4	2.4	-2.5	-0.1
Reaction time mean minus median AUC	1.1	2.9	4.0	-1.9	2.0	-2.0	0.4
Reaction time num false alarms	2.4	3.4	5.5	1.6	-2.0	1.3	-2.4
Reaction time num false alarms AUC	2.4	3.8	6.4	1.8	-2.0	1.2	-2.5
Reaction time trials correct on left	0.3	0.5	0.8	0.7	-0.9	0.8	-0.5
Reaction time trials on left	0.2	0.4	0.6	0.6	-0.8	0.6	-0.6
Reaction time mean	4.7	7.5	12.3	-2.5	3.3	-3.5	0.7
Reaction time mean AUC	4.4	7.1	12.0	-2.4	3.2	-3.5	0.4
Median of all reaction times	4.5	6.3	10.5	-2.1	3.1	-3.2	1.0
Reaction time omissions	1.7	2.5	3.7	-1.4	1.9	-1.9	-0.7
Reaction time false alarm rate	1.3	1.8	3.4	1.2	-1.4	0.8	-1.8
Reaction time premature initiation rate	2.6	3.6	5.3	1.2	-1.6	2.3	2.2
Reaction time premature initiations	2.1	3.7	6.4	1.5	-1.9	2.5	1.5
Std. dev. reaction times	3.4	6.2	9.5	-2.5	2.9	-3.1	0.5
Reaction time trials completed	0.2	0.4	0.6	0.6	-0.8	0.6	-0.6
Reaction time trials AUC	0.2	0.5	0.6	0.7	-0.8	0.7	-0.6
Run reversals in cocaine runway, females	0.2	0.2	0.3	0.6	0.1	-0.4	0.3
Run reversals in cocaine runway, males	0.3	0.3	0.5	-0.3	-0.4	0.6	0.7
Latency to leave start box in cocaine runway	3.3	3.7	5.6	2.0	-2.4	2.0	-1.0
Latency to leave start box in cocaine runway, F	2.3	2.7	4.2	1.7	-2.0	1.8	-0.5
Latency to leave start box in cocaine runway, M	2.1	2.0	2.9	1.5	-1.7	1.6	-0.7
Std. dev. time between licks in bursts	0.9	1.2	1.7	0.9	-1.3	1.2	-0.8
Total sessions with >9 infusions	0.5	0.6	2.3	0.2	-0.4	-0.3	-1.5
Short access day 1 total inactive lever presses	0.3	0.4	1.7	0.1	-0.1	-0.3	-1.3
Short access day 10 total inactive lever presses	0.2	0.4	1.4	0.2	-0.4	0.3	-1.2
Short access day 1 total infusions	0.7	0.9	2.6	-0.6	0.5	-0.7	-1.6
Short access day 10 total infusions	1.3	1.6	4.2	-0.7	0.9	-2.1	-1.0
Short access total infusions	0.6	0.7	1.6	-0.4	0.3	-1.0	-1.3
Short access day 1 locomotion	0.3	0.4	0.9	0.1	0.0	-0.7	-1.0
Short access day 10 total locomotion	0.5	0.9	1.8	0.8	-0.9	0.4	-1.4
Short access total locomotion	1.0	1.2	4.2	0.6	-0.6	-0.2	-2.0
One hour access (0.3 mA shock)	1.5	1.7	2.4	-1.4	1.0	-1.6	-1.3
Compulsive drug intake	0.7	0.8	1.5	0.6	-1.0	1.2	-0.7
One hour access (shock baseline)	1.4	2.2	4.6	-1.5	1.4	-2.1	-0.5
Social response proportion	2.0	2.2	4.1	-1.5	2.0	-1.6	0.2
Social responses	0.7	0.9	1.8	-0.6	1.3	-0.9	-0.8
Social time	0.7	1.0	1.7	-0.9	1.3	-0.5	1.1
Soleus weight	0.0	0.1	0.2	-0.5	0.1	-0.2	-0.1
Bone: stiffness	3.9	6.3	9.1	-2.7	2.8	-3.0	-0.9
Tibialis anterior weight	0.7	2.2	2.9	1.2	-1.6	1.5	-1.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	-0.8	0.5	-0.5	-0.3
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.4	-0.6	0.6	-0.5	0.4
Time to tail flick, test, before self-admin	0.4	0.4	0.8	0.3	-0.9	0.5	-0.6
Time to tail flick, test, after self-admin	0.8	0.8	1.0	0.8	-0.8	1.0	-1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.5	-0.1	0.5	0.4
Tibia length	4.9	13.4	19.0	-4.4	4.3	-4.0	0.4
Ambulatory time before self-admin	1.0	1.5	3.1	-0.5	1.8	-1.6	0.4
Ambulatory time after self-admin	0.2	0.2	0.8	0.9	-0.1	-0.0	-0.2
Bone: tissue strength	2.9	2.9	4.8	-2.2	1.6	-1.6	-1.3
Total heroin consumption	0.9	1.0	2.3	-0.4	1.0	-1.5	-0.7
Bone: trabecular number	1.6	2.7	3.8	-2.0	1.8	-1.8	-0.5
Bone: trabecular spacing	0.9	1.1	1.5	1.0	-0.9	1.2	1.1
Bone: trabecular thickness	0.8	1.0	1.5	-1.2	1.1	-1.2	0.1
Bone: trabecular tissue density	0.4	0.6	1.7	0.4	0.2	-0.7	-1.3
Water consumed over 24 hours	0.4	0.6	2.0	0.1	-0.5	0.1	-1.4
Number of responses in last shaping day	0.3	0.4	1.2	-0.4	-0.3	-0.1	-1.1