Hub : Genes

Stac2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Stac2 0.08 0.06 1.3e-07 0.07 0.07 0.06 0.06 4.0e-07 2.4e-07 2.4e-06 2.9e-06
2 PL alternative TSS XM_039086503.1 0.05 0.05 1.3e-04 0.02 0.02 0.01 0.01 6.3e-03 1.0e-03 2.2e-02 1.8e-02
3 PL alternative TSS XM_039086503.1 0.04 0.04 2.5e-04 0.01 0.02 0.01 0.01 8.1e-03 2.0e-03 4.2e-02 2.5e-02
4 IL gene expression Stac2 0.19 0.16 1.6e-03 0.11 0.02 0.09 0.08 1.5e-03 1.3e-01 3.6e-03 7.1e-03
5 PL alternative TSS XM_039086504.1 0.05 0.04 1.9e-04 0.01 0.02 0.01 0.01 8.6e-03 1.0e-03 3.0e-02 2.1e-02
6 PL alternative TSS XM_039086504.1 0.04 0.04 2.9e-04 0.01 0.02 0.01 0.01 1.2e-02 1.8e-03 4.5e-02 2.8e-02
7 NAcc mRNA stability Stac2 0.03 0.03 2.1e-04 0.03 0.03 0.03 0.03 1.1e-04 3.5e-04 2.1e-04 3.3e-04
8 Brain gene expression Stac2 0.08 0.05 2.0e-08 0.08 0.08 0.07 0.07 6.8e-08 1.0e-07 2.6e-07 3.0e-07
9 OFC gene expression Stac2 0.28 0.23 9.7e-04 0.04 0.04 0.03 0.02 3.5e-02 3.3e-02 5.6e-02 1.3e-01
10 PL gene expression Stac2 0.11 0.07 1.4e-12 0.1 0.09 0.08 0.1 1.7e-11 1.6e-10 3.0e-09 9.5e-11
11 Brain alternative TSS XM_039086503.1 0.03 0.04 5.9e-03 0.03 0.02 0.02 0.02 1.6e-03 9.1e-03 6.2e-03 7.8e-03
12 Brain alternative TSS XM_039086504.1 0.03 0.03 8.5e-03 0.03 0.01 0.02 0.02 1.5e-03 1.3e-02 7.7e-03 1.0e-02
13 Brain alternative TSS XM_039086503.1 0.03 0.04 9.6e-03 0.02 0.01 0.02 0.02 2.4e-03 1.8e-02 7.1e-03 7.7e-03
14 PL mRNA stability Stac2 0.05 0.04 2.3e-06 0.06 0.05 0.05 0.05 3.3e-07 2.5e-06 7.0e-06 1.6e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.44.04.32.0-2.1-2.0-2.12.02.0-2.1-2.11.9-1.91.9-1.91.9-1.9
Area under the delay curve0.60.71.00.9-0.9-0.9-1.00.90.9-0.8-0.91.0-0.80.7-0.70.7-0.5
BMI with tail1.85.86.4-2.42.42.42.2-2.4-2.42.52.4-2.32.3-2.52.5-2.52.4
BMI without tail0.10.10.3-0.40.40.40.2-0.4-0.40.60.5-0.40.1-0.30.3-0.30.1
Body weight6.125.628.1-5.25.25.25.2-5.2-5.25.35.3-5.14.8-4.84.8-4.84.7
Weight adjusted by age0.30.30.7-0.40.40.40.4-0.4-0.40.50.3-0.40.6-0.90.9-0.90.7
Bone surface0.00.00.1-0.0-0.0-0.00.10.00.0-0.0-0.0-0.1-0.20.2-0.20.2-0.2
Bone volume0.10.20.30.4-0.5-0.5-0.40.50.4-0.5-0.50.3-0.60.6-0.60.6-0.6
Breakpoint value in progressive ratio session0.91.01.6-1.21.21.21.2-1.2-1.21.31.2-1.20.8-0.30.3-0.30.7
Number of licking bursts0.50.60.80.8-0.8-0.8-0.80.80.8-0.9-0.90.8-0.60.6-0.60.6-0.6
Context. condit. distance diff. score0.70.81.3-0.80.80.80.8-0.8-0.80.70.8-0.71.0-1.21.2-1.21.1
Locomotion velocity, session 10.60.70.9-0.90.90.90.8-0.9-0.90.90.9-1.00.7-0.60.6-0.60.7
Locomotion distance, session 13.34.25.5-2.22.22.22.3-2.2-2.22.32.3-2.31.6-1.61.6-1.61.6
Locomotion velocity, session 20.50.60.9-0.80.80.80.8-0.8-0.80.80.8-0.90.7-0.60.6-0.60.6
Locomotion distance, session 20.60.91.5-1.11.01.11.2-1.1-1.11.21.2-1.20.5-0.40.4-0.40.4
Locomotion velocity, session 30.10.20.2-0.40.40.40.5-0.4-0.40.40.4-0.50.4-0.30.3-0.30.3
Locomotion distance, session 30.50.50.7-0.70.70.70.9-0.7-0.70.80.8-0.80.6-0.60.6-0.60.6
Stereotopy head waving bouts, day 33.54.14.82.1-2.1-2.1-2.02.12.1-2.2-2.22.1-1.91.9-1.91.9-1.9
Stereotopy head waving duration, day 30.40.50.80.7-0.7-0.7-0.70.70.7-0.9-0.90.8-0.50.5-0.50.5-0.5
Locomotion velocity, session 70.91.01.0-1.01.01.01.0-1.0-1.01.01.0-0.91.0-1.01.0-1.01.0
Locomotion distance, session 70.10.20.2-0.40.40.40.4-0.4-0.40.40.4-0.30.4-0.40.4-0.40.4
Stereotopy head waving bouts, day 70.91.11.41.1-1.1-1.1-1.21.11.1-1.2-1.21.1-0.90.8-0.80.8-0.9
Stereotopy head waving duration, day 70.20.30.40.6-0.6-0.6-0.60.60.6-0.6-0.60.5-0.40.4-0.40.4-0.4
Locomotion velocity, session 87.79.29.8-3.03.03.02.9-3.0-3.02.92.9-2.93.1-3.13.1-3.13.1
Locomotion distance, session 81.42.12.7-1.61.51.51.5-1.5-1.51.61.6-1.61.2-1.21.2-1.21.2
Degree of sensitization distance0.50.50.7-0.60.60.60.5-0.6-0.60.50.5-0.50.8-0.80.8-0.80.8
Degree of sensitization stereotypy1.61.82.21.4-1.4-1.4-1.51.41.4-1.5-1.51.4-1.21.1-1.11.1-1.2
Conditioned locomotion0.10.10.10.3-0.3-0.3-0.30.30.3-0.3-0.30.3-0.30.4-0.40.4-0.3
Cocaine response after cond. corrected2.52.83.21.7-1.8-1.7-1.81.71.7-1.8-1.81.7-1.61.5-1.51.5-1.6
Cocaine response after cond. not corrected3.74.15.02.1-2.1-2.1-2.12.12.1-2.2-2.22.1-1.81.8-1.81.8-1.8
Cocaine response before conditioning0.60.71.21.0-0.9-0.9-0.80.90.9-1.1-1.11.1-0.50.5-0.50.5-0.5
Saline control response0.20.20.40.5-0.5-0.5-0.60.50.5-0.6-0.60.7-0.20.1-0.10.1-0.2
Bone: connectivity density3.14.95.22.2-2.2-2.2-2.32.22.2-2.2-2.22.1-2.22.2-2.22.2-2.2
Bone: cortical apparent density6.07.98.42.9-2.9-2.9-2.82.92.9-2.9-2.92.8-2.72.7-2.72.7-2.7
Bone: cortical area0.20.30.40.6-0.6-0.6-0.60.60.6-0.6-0.60.6-0.40.4-0.40.4-0.4
Bone: cortical porosity0.50.50.80.8-0.8-0.8-0.80.80.8-0.9-0.90.9-0.40.4-0.40.4-0.4
Bone: cortical porosity0.60.61.10.9-0.9-0.9-0.90.90.9-1.0-1.01.0-0.40.4-0.40.4-0.4
Bone: cortical thickness1.52.53.51.8-1.8-1.8-1.91.81.7-1.8-1.81.7-1.21.2-1.21.2-1.2
Bone: cortical thickness4.85.66.72.6-2.5-2.5-2.42.52.5-2.6-2.62.5-2.12.1-2.12.1-2.1
Bone: cortical tissue density6.07.98.42.9-2.9-2.9-2.82.92.9-2.9-2.92.8-2.72.7-2.72.7-2.7
Condit. Reinf. active minus inactive responses0.50.50.60.7-0.7-0.7-0.70.70.7-0.7-0.70.7-0.70.8-0.80.8-0.7
Condit. Reinf. active-inactive response ratio0.60.70.70.8-0.8-0.8-0.90.80.8-0.8-0.80.9-0.80.8-0.80.8-0.8
Condit. Reinf. active responses0.70.91.11.0-1.0-1.0-1.01.01.0-1.1-1.00.9-0.80.9-0.90.9-0.8
Condit. Reinf. inactive responses0.40.50.90.8-0.8-0.8-0.90.80.8-1.0-1.00.8-0.30.3-0.30.3-0.3
Incentive salience index mean1.51.82.11.3-1.3-1.3-1.41.31.3-1.4-1.31.3-1.31.4-1.41.4-1.4
Condit. Reinf. lever presses1.21.61.71.2-1.2-1.2-1.31.21.2-1.3-1.21.2-1.21.3-1.31.3-1.2
Condit. Reinf. active minus inactive responses0.50.60.70.8-0.8-0.8-0.70.80.8-0.8-0.80.8-0.80.8-0.80.8-0.8
Condit. Reinf. active-inactive response ratio0.30.40.50.6-0.6-0.6-0.60.60.6-0.5-0.50.5-0.60.7-0.70.7-0.7
Condit. Reinf. active responses1.01.41.51.2-1.1-1.2-1.01.21.2-1.1-1.11.2-1.21.2-1.21.2-1.2
Condit. Reinf. inactive responses2.12.62.91.6-1.6-1.6-1.41.61.6-1.6-1.61.7-1.61.6-1.61.6-1.6
Condit. Reinf. lever presses0.00.00.00.2-0.2-0.2-0.20.20.2-0.2-0.20.2-0.20.1-0.10.1-0.2
Condit. Reinf. lever reinforcers received1.01.31.61.1-1.1-1.1-1.01.11.1-1.1-1.11.1-1.21.3-1.31.3-1.2
Conditioned reinforcement - actives1.01.01.51.1-1.0-1.0-1.11.11.1-1.2-0.91.2-1.10.7-0.70.7-1.0
Conditioned reinforcement - inactives1.11.31.81.1-1.0-1.1-1.11.11.1-1.0-0.91.1-1.21.3-1.31.3-1.3
Conditioned locomotion0.91.01.61.1-1.1-1.1-1.31.11.1-1.0-1.01.2-0.90.7-0.70.7-0.7
Patch foraging indifference point 0 sec2.03.15.01.5-1.6-1.6-1.51.61.6-1.4-1.41.5-2.22.2-2.22.2-2.2
Patch foraging indifference point AUC0.00.00.1-0.0-0.00.00.10.0-0.0-0.1-0.1-0.1-0.40.3-0.30.3-0.4
Delay disc. indifference point, 0s delay1.31.41.71.2-1.2-1.2-1.11.21.2-1.0-1.11.2-1.21.3-1.31.3-1.1
Delay disc. indifference point, 16s delay0.70.70.90.9-0.9-0.9-0.90.90.9-0.9-1.00.9-0.80.7-0.70.7-0.5
Delay disc. indifference point, 2s delay2.12.32.91.6-1.6-1.6-1.71.61.6-1.5-1.51.7-1.71.2-1.21.2-1.5
Delay disc. indifference point, 24s delay0.10.10.10.3-0.3-0.3-0.40.30.3-0.3-0.30.3-0.10.1-0.10.1-0.0
Delay disc. indifference point, 4s delay0.70.71.20.9-0.9-0.9-1.10.90.9-0.6-0.80.8-1.00.7-0.70.7-0.9
Delay disc. indifference point, 8s delay0.40.40.80.7-0.6-0.7-0.90.70.7-0.5-0.70.8-0.70.6-0.60.6-0.4
Indifference point function ln k0.00.00.00.0-0.0-0.0-0.20.00.00.1-0.00.1-0.10.1-0.10.1-0.1
Indifference point function log k0.00.00.00.0-0.0-0.0-0.20.00.00.1-0.00.1-0.10.1-0.10.1-0.1
Patch foraging total patch changes 0 sec1.52.44.21.3-1.3-1.3-1.21.31.3-1.1-1.11.2-2.12.0-2.02.0-2.0
Patch foraging total patch changes 12 sec5.47.08.32.6-2.6-2.6-2.52.62.6-2.6-2.52.5-2.92.8-2.82.8-2.8
Patch foraging total patch changes 18 sec0.81.11.70.9-0.9-0.9-0.70.90.9-0.9-1.00.8-1.31.2-1.21.2-1.2
Patch foraging total patch changes 24 sec2.53.03.61.8-1.8-1.8-1.71.81.8-1.9-1.81.6-1.71.7-1.71.7-1.7
Patch foraging total patch changes 6 sec2.33.45.21.6-1.7-1.7-1.51.71.7-1.5-1.51.5-2.22.3-2.32.3-2.2
Patch foraging time to switch 0 sec0.00.00.10.2-0.2-0.2-0.10.20.2-0.2-0.20.20.00.0-0.00.00.0
Patch foraging water rate 0 sec0.00.00.1-0.10.10.10.0-0.1-0.10.30.2-0.2-0.20.3-0.30.3-0.3
Patch foraging water rate 12 sec0.20.30.4-0.60.60.60.6-0.6-0.60.60.6-0.70.5-0.40.4-0.40.4
Patch foraging water rate 18 sec0.40.60.70.7-0.7-0.7-0.80.70.7-0.7-0.70.8-0.80.8-0.80.8-0.9
Patch foraging water rate 24 sec0.30.40.70.6-0.5-0.6-0.60.50.6-0.4-0.40.6-0.70.8-0.80.8-0.8
Patch foraging water rate 6 sec1.11.72.61.1-1.1-1.1-0.91.11.1-1.1-1.21.1-1.41.6-1.61.6-1.5
Seeking ratio, delayed vs. immediate footshock0.00.00.10.1-0.1-0.10.10.10.1-0.3-0.2-0.0-0.2-0.00.0-0.0-0.2
Distance traveled before self-admin0.20.20.5-0.60.60.60.7-0.6-0.50.60.6-0.50.4-0.20.2-0.20.1
Distance traveled after self-admin1.82.02.5-1.51.61.61.5-1.6-1.51.41.5-1.41.1-1.21.2-1.21.2
Extensor digitorum longus weight9.035.438.8-5.95.85.95.7-5.9-5.95.75.7-5.86.2-6.26.2-6.26.2
Bone: elastic displacement0.00.00.00.1-0.1-0.1-0.20.10.1-0.1-0.10.10.1-0.10.1-0.10.1
Bone: elastic work0.00.00.00.1-0.1-0.1-0.10.10.1-0.1-0.1-0.0-0.00.0-0.00.0-0.0
Bone: endosteal estimation2.04.35.8-2.32.32.32.4-2.3-2.32.22.2-2.21.6-1.71.7-1.71.6
Bone: endosteal perimeter1.73.54.6-2.12.02.02.1-2.0-2.02.12.1-2.01.5-1.51.5-1.51.5
Epididymis fat weight0.30.71.3-0.91.01.01.1-1.0-0.90.91.0-0.80.6-0.60.6-0.60.6
Delta time in closed arm before/after self-admin4.74.56.7-2.02.02.01.8-2.0-2.02.01.9-1.92.6-2.42.4-2.42.4
Delta time in open arm before/after self-admin0.00.00.10.2-0.2-0.2-0.10.20.2-0.1-0.20.2-0.10.2-0.20.2-0.1
Diff in mean of infusions in LGA sessions0.60.71.4-0.70.80.80.9-0.8-0.80.80.7-0.51.2-0.70.7-0.70.9
Delay discount exponential model param0.30.30.6-0.60.60.60.8-0.6-0.60.50.7-0.70.6-0.40.4-0.40.3
Extinction: sum of active levers before priming1.01.01.6-1.01.11.00.9-1.0-1.01.01.1-0.80.8-1.01.0-1.01.3
Active lever presses in extinction session 61.00.92.50.6-0.6-0.6-0.50.60.6-0.3-0.40.5-1.31.6-1.61.6-1.3
Bone: final force1.21.92.41.4-1.4-1.4-1.31.41.4-1.5-1.51.5-1.31.3-1.31.3-1.3
Bone: final moment0.91.52.01.3-1.3-1.3-1.21.31.3-1.4-1.41.3-1.11.1-1.11.1-1.1
Food consumed during 24 hour testing period0.81.01.1-1.01.01.01.0-1.0-1.01.01.0-1.11.0-1.01.0-1.01.0
Glucose0.71.01.21.0-1.0-1.0-1.11.01.0-0.9-0.91.0-1.11.1-1.11.1-1.1
Heart weight3.34.65.5-2.32.32.32.3-2.3-2.32.32.2-2.22.0-1.91.9-1.91.9
Delay discount hyperbolic model param0.50.60.9-0.80.80.81.0-0.8-0.80.60.8-0.90.8-0.60.6-0.60.5
Intermittent access intake day 1-15 change0.10.10.10.3-0.3-0.3-0.30.30.3-0.2-0.10.3-0.0-0.20.2-0.20.1
Intermittent access intake escalation0.00.00.00.2-0.1-0.2-0.20.10.2-0.10.00.2-0.0-0.20.2-0.20.1
Intermittent access intake escalation 20.20.20.4-0.30.30.30.3-0.3-0.30.20.3-0.30.3-0.60.6-0.60.6
Intermitt. access day 1 inactive lever presses0.50.50.70.8-0.8-0.8-0.60.80.8-0.7-0.60.8-0.60.8-0.80.8-0.5
Intermitt. access day 15 inactive lever presses2.93.23.61.9-1.9-1.9-1.81.91.9-1.8-1.91.7-1.61.7-1.71.7-1.7
Intermitt. access escalation Index1.41.32.6-0.90.90.90.7-0.9-0.90.90.8-0.81.2-1.61.6-1.61.4
Intermittent access day 1 total infusions0.10.20.30.3-0.3-0.3-0.30.30.3-0.2-0.20.4-0.50.6-0.60.6-0.6
Intermittent access day 15 total infusions0.20.20.30.4-0.4-0.4-0.50.40.4-0.3-0.20.5-0.50.4-0.40.4-0.5
Intermittent access terminal intake (last 3 days)0.30.30.50.5-0.5-0.5-0.50.50.5-0.5-0.20.6-0.60.7-0.70.7-0.6
Intermittent access total infusions0.00.00.10.1-0.0-0.1-0.00.10.1-0.00.20.1-0.30.2-0.20.2-0.3
Intermittent access day 1 locomotion0.40.50.80.6-0.6-0.6-0.60.60.6-0.5-0.50.6-0.70.9-0.90.9-0.8
Intermittent access day 15 total locomotion0.50.50.70.7-0.7-0.7-0.80.70.7-0.6-0.60.8-0.80.7-0.70.7-0.7
Intermittent access total locomotion0.60.70.90.8-0.8-0.8-0.90.80.8-0.7-0.70.9-0.80.9-0.90.9-0.8
Intermittent access standard deviation0.30.30.60.5-0.4-0.5-0.30.40.5-0.4-0.20.4-0.80.8-0.80.8-0.8
Left kidney weight2.15.96.9-2.52.52.52.5-2.5-2.52.62.6-2.62.3-2.22.2-2.22.0
Right kidney weight0.41.11.4-1.11.11.11.1-1.1-1.11.11.0-1.21.0-0.90.9-0.90.8
Cocaine induced anxiety1.92.22.6-1.61.61.61.6-1.6-1.61.41.5-1.61.6-1.21.2-1.21.3
Post-drug Anxiety0.00.00.1-0.20.20.20.2-0.2-0.20.10.1-0.1-0.10.2-0.20.2-0.3
Baseline Anxiety3.03.24.81.8-1.8-1.8-1.91.81.8-1.7-1.71.9-2.21.6-1.61.6-1.9
Tail length0.72.33.3-1.71.61.61.6-1.6-1.61.81.8-1.81.3-1.01.0-1.01.1
Length with tail4.416.219.2-4.24.24.24.3-4.2-4.24.44.3-4.33.8-3.53.5-3.53.6
Length without tail5.111.112.5-3.43.43.43.5-3.4-3.43.33.3-3.33.3-3.23.2-3.23.4
Times rat made contact with spout1.11.21.61.2-1.2-1.2-1.31.21.2-1.2-1.21.1-0.91.0-1.01.0-1.0
Lifetime Intake0.00.00.10.00.0-0.00.10.00.00.00.20.1-0.20.2-0.20.2-0.3
Liver weight, left0.10.20.2-0.30.30.30.2-0.3-0.30.40.4-0.40.4-0.50.5-0.50.4
Liver weight, right0.10.20.50.2-0.2-0.2-0.20.20.2-0.1-0.20.2-0.50.6-0.60.6-0.7
Locomotor activity0.60.91.31.0-1.0-1.0-1.11.01.0-1.1-1.01.0-0.80.8-0.80.8-0.8
Locomotor testing distance2.74.55.32.2-2.1-2.2-2.32.22.2-2.3-2.12.3-2.01.9-1.91.9-2.0
Locomotor testing rearing6.39.712.03.0-3.0-3.0-2.93.03.0-3.0-2.83.0-3.53.4-3.43.4-3.4
Locomotion in novel chamber6.68.110.12.7-2.9-2.9-2.92.82.8-2.6-3.02.5-3.02.9-2.92.9-3.2
Locomotion in novel chamber post-restriction0.91.11.81.0-1.0-1.0-1.01.01.0-0.9-0.90.9-1.41.1-1.11.1-1.1
Fecal boli incidents, locomotor time 10.10.10.2-0.40.40.40.3-0.4-0.40.00.2-0.50.4-0.20.2-0.20.3
Change in fecal boli incidents, locomotor task0.10.10.20.3-0.2-0.2-0.30.30.3-0.2-0.20.4-0.3-0.10.1-0.1-0.1
Time >=10cm from walls, locomotor time 10.80.81.20.9-0.9-0.9-1.00.90.9-1.1-0.90.9-1.00.8-0.80.8-0.8
Bouts of movement, locomotor time 10.70.71.1-0.80.90.90.9-0.9-0.90.70.9-0.70.8-0.90.9-0.91.0
Total resting periods, locomotor time 11.11.21.5-1.01.11.11.1-1.1-1.10.81.0-0.91.1-1.21.2-1.21.2
Rest time, locomotor task time 10.00.00.1-0.00.00.0-0.0-0.0-0.0-0.3-0.10.00.1-0.10.1-0.10.1
Distance moved, locomotor task time 10.30.30.70.5-0.5-0.5-0.50.50.5-0.3-0.40.5-0.70.7-0.70.7-0.9
Vertical activity count, locomotor time 10.00.00.1-0.20.20.10.1-0.2-0.10.40.2-0.1-0.20.1-0.10.1-0.1
Time >=10cm from walls, locomotor time 22.42.53.31.5-1.5-1.5-1.71.51.5-1.5-1.61.5-1.81.5-1.51.5-1.8
Bouts of movement, locomotor time 20.00.00.10.2-0.1-0.1-0.10.10.20.1-0.10.2-0.10.2-0.20.20.0
Total resting periods, locomotor time 20.00.00.1-0.10.10.10.2-0.1-0.10.30.2-0.00.2-0.10.1-0.10.3
Rest time, locomotor task time 21.21.41.7-1.21.31.21.3-1.3-1.21.21.2-1.21.1-1.21.2-1.21.1
Distance moved, locomotor task time 20.10.20.50.2-0.2-0.2-0.30.20.20.10.00.1-0.60.6-0.60.6-0.7
Vertical activity count, locomotor time 20.00.00.1-0.10.10.10.0-0.1-0.10.40.3-0.10.00.2-0.20.20.1
Light reinforcement 12.03.64.51.9-1.9-1.9-1.81.91.9-1.9-1.71.9-2.11.9-1.91.9-2.1
Light reinforcement 20.70.91.11.0-1.0-1.0-0.81.01.0-1.0-0.90.9-1.00.9-0.90.9-1.0
Bone: marrow area1.94.15.5-2.22.22.22.3-2.2-2.22.22.2-2.11.6-1.61.6-1.61.6
Bone: maximum diameter0.00.00.10.1-0.2-0.20.00.20.2-0.2-0.20.1-0.30.2-0.20.2-0.3
Bone: maximum force0.00.10.10.3-0.2-0.2-0.20.30.3-0.4-0.40.3-0.20.2-0.20.2-0.2
Bone: maximum moment0.00.00.10.1-0.1-0.1-0.10.10.1-0.2-0.20.2-0.10.1-0.10.1-0.1
Mean time between licks in bursts1.31.92.1-1.41.41.41.3-1.4-1.41.41.4-1.41.3-1.31.3-1.31.3
Mean num. licks in bursts0.00.00.00.1-0.1-0.1-0.20.10.10.00.00.0-0.10.2-0.20.2-0.1
Cd content in liver0.10.10.30.3-0.3-0.3-0.40.30.3-0.3-0.30.3-0.50.4-0.40.4-0.5
Co content in liver1.21.42.0-1.21.21.21.4-1.2-1.21.11.1-1.31.1-1.11.1-1.11.1
Cu content in liver0.50.61.1-0.90.90.91.0-0.9-0.91.01.0-1.00.2-0.20.2-0.20.2
Fe content in liver1.31.52.2-1.31.31.31.2-1.3-1.31.51.5-1.31.1-1.01.0-1.01.1
K content in liver0.90.91.80.7-0.8-0.8-0.70.80.7-0.5-0.50.6-1.41.3-1.31.3-1.4
Mg content in liver0.60.71.10.7-0.8-0.7-0.60.70.7-0.5-0.50.6-1.01.0-1.01.0-1.0
Mn content in liver1.31.52.71.0-1.0-1.0-0.91.01.0-0.8-0.80.8-1.71.6-1.61.6-1.7
Na content in liver0.30.40.50.5-0.6-0.6-0.50.60.5-0.5-0.50.5-0.60.7-0.70.7-0.6
Rb content in liver1.72.13.21.2-1.2-1.2-1.31.21.2-1.0-1.01.2-1.81.8-1.81.8-1.8
Se content in liver3.24.05.21.9-1.9-1.9-1.61.91.9-1.8-1.81.7-2.22.3-2.32.3-2.2
Sr content in liver0.10.10.2-0.30.30.30.3-0.3-0.30.40.4-0.40.00.1-0.10.10.0
Zn content in liver1.82.02.51.4-1.4-1.4-1.21.41.4-1.2-1.21.4-1.61.5-1.51.5-1.6
Bone: minimum diameter0.30.71.0-1.00.90.91.0-0.9-0.91.01.0-0.90.4-0.50.5-0.50.4
Time in familiar zone, hab. session 10.40.40.70.7-0.6-0.7-0.80.60.7-0.6-0.60.7-0.50.5-0.50.5-0.5
Time in novel zone, hab. session 10.70.70.80.9-0.9-0.8-0.70.90.8-0.9-0.90.8-0.90.9-0.90.9-0.9
Total zone transitions, hab. session 12.23.13.4-1.81.81.81.8-1.8-1.81.81.8-1.81.7-1.71.7-1.71.7
Total locomotion distance, hab. session 10.00.10.1-0.20.20.20.2-0.2-0.20.20.2-0.20.4-0.30.3-0.30.4
Locomotion velocity, hab. session 10.71.01.1-1.01.01.00.9-1.0-1.00.90.9-1.01.0-1.01.0-1.01.0
Time in familiar zone, hab. session 20.40.50.60.7-0.6-0.7-0.60.70.7-0.6-0.50.7-0.70.8-0.80.8-0.7
Time in novel zone, hab. session 20.10.10.10.2-0.2-0.2-0.30.20.2-0.2-0.30.2-0.20.2-0.20.2-0.2
Total zone transitions, hab. session 20.60.71.0-0.90.90.91.0-0.9-0.90.91.0-0.90.7-0.70.7-0.70.7
Total locomotion distance, hab. session 20.20.20.3-0.40.40.40.4-0.4-0.40.40.4-0.40.5-0.50.5-0.50.5
Locomotion velocity, hab. session 20.40.50.6-0.70.70.70.7-0.7-0.70.70.7-0.60.8-0.80.8-0.80.8
Novel to familiar place preference ratio1.41.41.6-1.21.21.21.2-1.2-1.21.31.2-1.21.1-1.21.2-1.21.2
Novelty place preference1.01.01.2-0.90.90.91.0-0.9-0.91.00.9-0.91.0-1.11.1-1.11.1
Time in novel zone, NPP test0.30.30.5-0.40.40.40.4-0.4-0.40.50.4-0.40.6-0.70.7-0.70.6
Total zone transitions, NPP test0.30.40.5-0.70.70.70.7-0.7-0.70.70.7-0.70.4-0.40.4-0.40.4
Total locomotion distance, NPP test0.00.00.10.1-0.1-0.1-0.00.10.1-0.1-0.10.0-0.20.2-0.20.2-0.2
Locomotion velocity, NPP test0.20.30.4-0.60.60.60.6-0.6-0.60.60.6-0.60.4-0.40.4-0.40.4
Intraocular pressure1.72.32.8-1.51.51.51.4-1.5-1.51.51.7-1.31.6-1.61.6-1.61.5
Delta distance traveled before/after self-admin1.11.21.4-1.11.21.21.0-1.2-1.21.01.1-1.10.9-1.11.1-1.11.2
Delta ambulatory time before/after self-admin0.40.40.7-0.60.70.70.5-0.7-0.70.60.6-0.50.6-0.80.8-0.80.8
Parametrial fat weight0.40.81.01.0-0.9-0.9-0.80.90.9-0.7-0.71.0-1.01.0-1.01.0-1.0
Pavlov. Cond. lever latency2.93.74.2-2.02.02.02.1-2.0-2.02.02.0-1.91.7-1.91.9-1.91.8
Pavlov. Cond. magazine entry latency10.513.515.03.8-3.8-3.8-3.93.83.8-3.8-3.83.7-3.43.5-3.53.5-3.4
Pavlov. Cond. change in total contacts8.59.110.43.1-3.1-3.1-3.23.13.1-3.1-3.13.0-2.72.9-2.92.9-2.8
Pavlov. Cond. index score8.911.212.73.5-3.4-3.4-3.63.43.4-3.5-3.43.4-3.13.2-3.23.2-3.1
Pavlov. Cond. latency score6.98.810.23.1-3.0-3.1-3.23.03.0-3.1-3.03.0-2.72.8-2.82.8-2.7
Pavlov. Cond. lever contacts2.53.03.91.8-1.8-1.8-2.01.81.8-1.8-1.81.8-1.41.6-1.61.6-1.5
Pavlov. Cond. magazine entry number13.516.818.5-4.24.24.24.3-4.2-4.24.24.2-4.13.8-3.93.9-3.93.9
Pavlov. Cond. intertrial magazine entries1.51.81.9-1.41.41.41.4-1.4-1.41.31.3-1.41.3-1.31.3-1.31.3
Pavlov. Cond. lever-magazine prob. diff.10.012.414.03.6-3.6-3.6-3.73.63.6-3.6-3.63.6-3.23.4-3.43.4-3.3
Pavlov. Cond. response bias9.912.013.53.6-3.6-3.6-3.73.63.6-3.6-3.53.5-3.23.3-3.33.3-3.2
Pavlov. Cond. lever latency0.20.30.5-0.60.60.60.7-0.6-0.50.60.6-0.50.4-0.40.4-0.40.4
Pavlov. Cond. magazine entry latency0.00.00.1-0.10.10.1-0.0-0.1-0.10.00.0-0.10.3-0.40.4-0.40.3
Pavlov. Cond. change in total contacts0.60.81.20.8-0.8-0.8-0.90.80.8-0.8-0.80.8-1.11.0-1.01.0-1.1
Pavlov. Cond. index score0.20.20.50.5-0.5-0.5-0.70.50.5-0.5-0.50.5-0.30.3-0.30.3-0.3
Pavlov. Cond. latency score0.10.10.40.4-0.4-0.4-0.60.40.4-0.4-0.40.3-0.20.2-0.20.2-0.2
Pavlov. Cond. lever contacts0.71.01.51.1-1.1-1.0-1.21.01.0-1.1-1.11.0-0.80.8-0.80.8-0.8
Pavlov. Cond. magazine entry number0.10.10.2-0.40.40.40.5-0.4-0.30.40.4-0.30.1-0.10.1-0.10.1
Pavlov. Cond. intertrial magazine entries1.82.32.7-1.51.51.51.6-1.5-1.51.41.4-1.41.6-1.61.6-1.61.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.3-0.4-0.3-0.50.30.3-0.3-0.30.3-0.20.2-0.20.2-0.2
Pavlov. Cond. response bias0.91.31.61.2-1.2-1.2-1.31.21.2-1.2-1.21.1-1.01.0-1.01.0-1.0
Time in closed arm before self-admin1.61.82.71.2-1.2-1.2-1.01.21.2-1.3-1.11.2-1.61.6-1.61.6-1.6
Time in closed arm after self-admin0.50.50.7-0.80.80.80.7-0.8-0.80.70.8-0.80.7-0.60.6-0.60.5
Time in open arm before self-admin3.03.33.9-1.91.91.91.6-1.9-1.92.01.8-1.91.6-1.71.7-1.71.8
Time in open arm after self-admin0.60.71.0-0.90.90.80.9-0.9-0.80.90.8-0.81.0-0.70.7-0.70.9
Bone: periosteal estimation0.10.30.6-0.60.60.60.7-0.6-0.60.60.6-0.60.3-0.30.3-0.30.3
Bone: periosteal perimeter0.61.11.3-1.11.11.11.2-1.1-1.11.11.1-1.01.0-1.01.0-1.01.0
Bone: post-yield work1.11.51.7-1.21.31.31.1-1.3-1.21.11.1-1.11.3-1.31.3-1.31.3
Progressive ratio test 1 active lever presses1.51.52.51.2-1.2-1.2-1.21.21.2-1.3-1.11.2-1.61.2-1.21.2-1.3
Progressive ratio test 1 breakpoint1.31.42.21.1-1.1-1.1-1.11.11.1-1.3-1.11.2-1.51.1-1.11.1-1.2
Progressive ratio test 1 inactive lever presses0.91.01.41.0-0.9-1.0-0.81.01.0-0.9-0.91.0-1.11.0-1.01.0-1.2
Progressive ratio test 2 active lever presses1.41.52.21.1-1.1-1.1-1.11.11.1-1.1-1.01.1-1.51.4-1.41.4-1.4
Progressive ratio test 2 breakpoint1.11.21.61.1-1.1-1.1-1.11.11.1-1.0-0.91.1-1.31.2-1.21.2-1.2
Progressive ratio test 2 inactive lever presses0.10.20.40.2-0.3-0.3-0.40.30.3-0.1-0.10.2-0.50.6-0.60.6-0.6
Incentive Sensitization - Responses1.11.21.31.1-1.1-1.1-1.11.11.1-1.1-1.11.1-1.01.0-1.01.0-1.0
Incentive Sensitization - Breakpoint1.11.11.31.1-1.1-1.1-1.11.11.1-1.1-1.11.0-1.01.0-1.01.0-1.0
Sum of active levers in priming session hrs 5-60.50.51.00.6-0.6-0.6-0.70.60.6-0.5-0.40.6-0.71.0-1.01.0-0.7
Progressive ratio0.00.00.20.1-0.1-0.1-0.00.10.1-0.3-0.20.0-0.40.3-0.30.3-0.2
Food seeking constrained by brief footshock0.30.30.60.5-0.5-0.5-0.40.50.5-0.6-0.50.5-0.80.6-0.60.6-0.8
Seeking ratio, punishment vs. effort0.10.10.30.4-0.4-0.4-0.50.40.4-0.3-0.30.5-0.20.1-0.10.1-0.3
Retroperitoneal fat weight0.10.30.4-0.60.60.60.7-0.6-0.60.50.6-0.50.3-0.20.2-0.20.3
Reaction time number correct0.81.21.5-1.11.01.01.0-1.0-1.01.21.2-1.01.1-1.21.2-1.21.1
Reaction time mean minus median0.20.30.7-0.30.30.30.3-0.3-0.30.20.2-0.20.7-0.80.8-0.80.9
Reaction time mean minus median AUC0.10.20.40.5-0.5-0.5-0.50.50.5-0.6-0.60.6-0.0-0.10.1-0.10.1
Reaction time num false alarms0.81.01.21.0-1.0-1.0-1.01.01.0-1.1-0.91.0-1.10.9-0.90.9-1.0
Reaction time num false alarms AUC0.50.71.00.9-0.9-0.9-0.80.90.9-1.0-0.80.9-0.80.6-0.60.6-0.7
Reaction time trials correct on left0.81.21.5-1.11.01.01.0-1.0-1.01.21.2-1.01.1-1.21.2-1.21.1
Reaction time trials on left0.81.21.5-1.01.01.01.0-1.0-1.01.21.2-1.01.1-1.11.1-1.11.1
Reaction time mean0.00.00.10.2-0.2-0.2-0.10.20.2-0.2-0.30.10.1-0.10.1-0.10.2
Reaction time mean AUC0.00.00.00.1-0.1-0.1-0.00.10.1-0.1-0.20.00.1-0.10.1-0.10.1
Median of all reaction times0.30.40.60.7-0.7-0.7-0.70.70.7-0.7-0.80.6-0.60.6-0.60.6-0.5
Reaction time omissions0.71.01.21.1-1.1-1.1-1.11.11.0-1.0-1.01.0-0.90.9-0.90.9-0.9
Reaction time false alarm rate1.11.62.21.3-1.3-1.3-1.31.31.3-1.5-1.31.3-1.21.1-1.11.1-1.1
Reaction time premature initiation rate0.20.30.50.6-0.5-0.5-0.40.50.6-0.7-0.70.7-0.30.3-0.30.3-0.3
Reaction time premature initiations0.10.10.3-0.20.30.30.4-0.3-0.30.20.2-0.10.5-0.50.5-0.50.5
Std. dev. reaction times0.10.10.20.1-0.1-0.1-0.00.10.1-0.1-0.20.10.3-0.50.5-0.50.5
Reaction time trials completed0.81.21.5-1.01.01.01.0-1.0-1.01.21.2-1.01.1-1.11.1-1.11.1
Reaction time trials AUC0.71.01.2-0.90.90.90.8-0.9-0.91.11.0-0.91.0-1.11.1-1.11.0
Run reversals in cocaine runway, females2.72.63.2-1.71.71.71.6-1.7-1.71.51.6-1.51.7-1.41.4-1.41.8
Run reversals in cocaine runway, males0.70.61.00.7-0.8-0.8-1.00.80.8-0.8-0.80.8-0.70.8-0.80.8-0.8
Latency to leave start box in cocaine runway2.72.93.5-1.81.71.71.6-1.7-1.71.81.8-1.91.7-1.61.6-1.61.6
Latency to leave start box in cocaine runway, F2.62.83.2-1.61.61.61.5-1.6-1.61.81.8-1.71.8-1.71.7-1.71.7
Latency to leave start box in cocaine runway, M0.10.10.3-0.40.30.30.3-0.3-0.30.50.5-0.5-0.20.3-0.30.3-0.3
Std. dev. time between licks in bursts0.20.20.3-0.50.50.50.4-0.5-0.50.40.4-0.60.5-0.50.5-0.50.5
Total sessions with >9 infusions0.80.91.40.9-0.9-0.9-0.90.90.9-0.9-0.80.9-1.11.0-1.01.0-1.2
Short access day 1 total inactive lever presses1.21.41.81.2-1.2-1.2-1.11.21.2-1.1-1.01.2-1.11.2-1.21.2-1.4
Short access day 10 total inactive lever presses0.80.91.5-0.80.90.80.9-0.8-0.80.81.0-0.91.2-1.01.0-1.01.2
Short access day 1 total infusions0.20.20.40.4-0.3-0.3-0.20.30.3-0.3-0.20.3-0.40.6-0.60.6-0.5
Short access day 10 total infusions0.30.30.80.4-0.4-0.4-0.40.40.4-0.3-0.20.4-0.80.7-0.70.7-0.9
Short access total infusions0.00.00.20.00.0-0.00.1-0.00.0-0.00.10.0-0.20.3-0.30.3-0.4
Short access day 1 locomotion2.72.93.41.7-1.7-1.7-1.61.71.7-1.6-1.81.6-1.61.9-1.91.9-1.5
Short access day 10 total locomotion1.92.12.51.4-1.4-1.5-1.61.51.5-1.3-1.31.5-1.41.5-1.51.5-1.4
Short access total locomotion0.30.30.40.6-0.6-0.6-0.50.60.6-0.5-0.60.6-0.60.6-0.60.6-0.5
One hour access (0.3 mA shock)0.00.10.20.00.0-0.0-0.00.00.0-0.00.10.20.0-0.50.5-0.50.3
Compulsive drug intake0.20.20.4-0.20.30.30.4-0.3-0.3-0.00.1-0.20.5-0.60.6-0.60.5
One hour access (shock baseline)0.10.10.20.3-0.3-0.3-0.30.30.3-0.0-0.00.4-0.50.3-0.30.3-0.4
Social response proportion0.00.00.0-0.00.00.0-0.0-0.0-0.00.0-0.10.10.1-0.10.1-0.10.1
Social responses0.20.20.50.3-0.3-0.3-0.20.30.3-0.1-0.20.3-0.60.7-0.70.7-0.7
Social time0.00.00.1-0.10.10.10.3-0.1-0.10.20.1-0.10.00.0-0.00.0-0.2
Soleus weight0.31.01.91.1-1.1-1.1-1.41.11.1-1.3-1.41.2-0.50.5-0.50.5-0.4
Bone: stiffness0.10.10.10.3-0.3-0.3-0.20.30.3-0.3-0.30.3-0.40.4-0.40.4-0.4
Tibialis anterior weight1.44.85.7-2.12.12.11.9-2.1-2.12.12.0-2.12.3-2.42.4-2.42.4
Time to tail flick, vehicle, before self-admin0.10.10.20.4-0.4-0.4-0.30.40.4-0.4-0.40.4-0.30.4-0.40.4-0.3
Time to tail flick, vehicle, after self-admin0.10.10.30.4-0.4-0.4-0.40.40.4-0.5-0.50.3-0.10.2-0.20.2-0.3
Time to tail flick, test, before self-admin1.11.11.7-1.01.01.00.9-1.0-1.00.80.9-0.81.1-1.31.3-1.31.2
Time to tail flick, test, after self-admin0.30.30.90.4-0.4-0.4-0.40.40.4-0.4-0.30.2-0.31.0-1.01.0-0.7
Delta time to tail flick, vehicle, before/after SA0.30.30.50.6-0.6-0.6-0.60.60.6-0.7-0.60.6-0.50.5-0.50.5-0.7
Delta time to tail flick, test, before/after SA3.33.05.01.5-1.6-1.6-1.51.61.6-1.5-1.51.3-1.62.2-2.22.2-1.9
Tibia length0.92.53.3-1.51.51.51.3-1.5-1.51.31.3-1.51.8-1.81.8-1.81.7
Ambulatory time before self-admin0.40.40.8-0.80.80.70.9-0.8-0.70.90.8-0.70.4-0.40.4-0.40.3
Ambulatory time after self-admin3.03.33.9-2.02.02.02.0-2.0-2.01.91.9-1.91.6-1.61.6-1.61.6
Bone: tissue strength0.50.50.8-0.60.60.60.4-0.6-0.60.50.5-0.60.9-0.90.9-0.90.9
Total heroin consumption0.80.92.10.7-0.7-0.7-0.70.70.7-0.5-0.80.6-1.01.5-1.51.5-1.1
Bone: trabecular number5.58.69.03.0-3.0-3.0-3.03.03.0-2.9-2.92.9-2.92.9-2.92.9-2.9
Bone: trabecular spacing1.01.31.4-1.21.21.21.1-1.2-1.21.21.2-1.11.1-1.11.1-1.11.1
Bone: trabecular thickness0.00.00.10.3-0.3-0.3-0.30.30.2-0.3-0.30.20.1-0.10.1-0.10.1
Bone: trabecular tissue density0.00.00.00.1-0.1-0.1-0.00.10.1-0.1-0.10.10.0-0.00.0-0.00.0
Water consumed over 24 hours0.00.10.2-0.00.00.00.1-0.0-0.0-0.1-0.1-0.00.4-0.40.4-0.40.4
Number of responses in last shaping day0.10.20.60.0-0.0-0.00.10.00.00.00.1-0.2-0.10.7-0.70.7-0.7