Hub : Genes

Stac2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS XM_063269538.1 0.03 0.04 6.2e-03 0.01 0.01 0.01 0.01 1.2e-02 9.8e-03 2.8e-02 1.7e-02
2 Brain gene expression Stac2 0.07 0.05 5.2e-07 0.05 0.07 0.06 0.06 1.7e-05 7.0e-07 3.5e-06 4.2e-06
3 IL gene expression Stac2 0.19 0.16 1.8e-03 0.09 0.02 0.1 0.07 3.7e-03 1.1e-01 1.7e-03 7.5e-03
4 NAcc gene expression Stac2 0.03 0.02 1.4e-04 0.02 0.02 0.01 0.02 4.7e-04 2.0e-04 2.3e-03 1.4e-03
5 PL mRNA stability Stac2 0.02 0.02 4.5e-03 0.02 0.02 0.01 0.01 2.9e-03 2.5e-03 2.1e-02 7.1e-03
6 LHb gene expression Stac2 0.18 0.17 5.9e-03 0.06 0.02 0.11 0.03 1.3e-02 8.8e-02 1.7e-03 7.5e-02
7 OFC gene expression Stac2 0.3 0.25 8.4e-04 0.06 0.03 0.03 0.04 1.7e-02 7.0e-02 6.2e-02 4.6e-02
8 PL gene expression Stac2 0.12 0.08 2.9e-12 0.1 0.1 0.1 0.1 2.2e-11 4.5e-11 2.0e-11 1.5e-11
9 IC gene expression Stac2 0.13 0.12 8.8e-04 0.07 0.07 0.06 0.07 6.8e-04 4.6e-04 1.6e-03 6.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density1.93.35.7-1.92.02.41.91.81.01.91.51.8
Area under the delay curve0.80.91.2-1.01.00.61.11.11.00.90.61.1
BMI with tail2.27.710.72.7-2.7-2.3-2.7-2.6-3.3-2.8-3.2-2.5
BMI without tail1.95.811.92.4-2.3-1.2-2.3-2.3-3.5-1.7-3.0-2.4
Body weight7.532.836.06.0-5.9-4.9-5.9-5.9-5.9-5.2-5.9-5.8
Weight adjusted by age0.10.20.70.3-0.4-0.7-0.3-0.40.3-0.8-0.2-0.3
Bone surface0.00.10.4-0.10.10.7-0.0-0.0-0.50.2-0.1-0.1
Bone volume0.10.20.8-0.40.40.90.40.40.10.50.40.3
Breakpoint value in progressive ratio session1.61.93.01.6-1.5-0.8-1.6-1.5-1.5-0.6-1.4-1.7
Number of licking bursts0.40.61.0-0.80.80.30.80.80.80.51.00.9
Context. condit. distance diff. score0.50.71.70.8-0.8-1.3-0.7-0.7-0.3-1.1-0.4-0.6
Locomotion velocity, session 10.70.81.30.9-1.0-0.6-1.0-1.0-1.2-0.6-0.4-1.0
Locomotion distance, session 14.05.08.72.3-2.2-1.1-2.3-2.3-3.0-1.5-2.5-2.4
Locomotion velocity, session 20.70.82.20.8-0.8-0.3-0.9-0.9-1.5-0.5-0.8-1.0
Locomotion distance, session 21.21.74.71.1-1.10.2-1.2-1.2-2.2-0.2-1.8-1.4
Locomotion velocity, session 30.30.41.60.4-0.30.4-0.4-0.4-1.3-0.1-0.9-0.5
Locomotion distance, session 30.50.61.20.7-0.7-0.2-0.8-0.8-1.0-0.5-1.1-0.8
Stereotopy head waving bouts, day 33.33.84.4-2.02.12.02.12.11.61.91.72.1
Stereotopy head waving duration, day 30.50.60.8-0.80.90.70.90.90.60.60.70.9
Locomotion velocity, session 70.80.91.71.0-1.0-1.3-1.0-0.9-0.6-0.9-0.7-0.9
Locomotion distance, session 70.20.20.80.5-0.4-0.9-0.3-0.30.4-0.40.0-0.3
Stereotopy head waving bouts, day 71.31.52.0-1.41.31.21.31.30.91.10.91.4
Stereotopy head waving duration, day 70.30.40.6-0.80.70.80.70.60.20.60.20.8
Locomotion velocity, session 86.88.29.43.0-3.0-3.1-2.9-2.9-2.5-3.0-2.4-2.9
Locomotion distance, session 81.62.43.01.6-1.6-1.2-1.6-1.6-1.6-1.3-1.7-1.6
Degree of sensitization distance0.40.41.80.6-0.6-1.3-0.5-0.50.4-0.80.1-0.4
Degree of sensitization stereotypy1.81.92.6-1.51.41.21.51.51.31.11.21.6
Conditioned locomotion0.20.20.3-0.40.40.30.50.50.60.50.40.4
Cocaine response after cond. corrected2.32.83.3-1.81.71.51.71.61.81.41.71.8
Cocaine response after cond. not corrected3.54.16.0-2.12.01.52.02.02.41.52.32.1
Cocaine response before conditioning0.60.71.8-0.60.70.10.80.81.40.31.20.8
Saline control response0.20.21.10.0-0.0-0.70.10.11.0-0.30.40.2
Bone: connectivity density2.74.27.8-2.22.22.82.12.10.92.21.52.0
Bone: cortical apparent density5.47.39.1-2.82.82.62.72.72.42.63.02.6
Bone: cortical area0.30.41.1-0.50.50.30.60.60.90.51.00.6
Bone: cortical porosity1.01.12.4-1.01.00.41.01.01.50.91.31.0
Bone: cortical porosity1.01.12.7-0.90.90.21.01.01.70.81.41.0
Bone: cortical thickness1.62.63.9-1.71.61.31.71.61.61.32.01.7
Bone: cortical thickness4.65.46.2-2.42.42.12.42.42.12.22.52.3
Bone: cortical tissue density5.47.39.0-2.82.82.72.72.72.42.63.02.6
Condit. Reinf. active minus inactive responses0.50.61.7-0.70.81.30.70.7-0.31.10.50.5
Condit. Reinf. active-inactive response ratio0.70.71.6-0.80.91.20.90.90.11.10.60.7
Condit. Reinf. active responses0.70.91.4-1.01.01.20.90.90.31.01.10.8
Condit. Reinf. inactive responses0.50.61.5-0.80.70.20.80.81.10.21.20.8
Incentive salience index mean1.41.83.1-1.31.31.81.31.30.51.61.41.1
Condit. Reinf. lever presses1.41.93.2-1.31.41.61.31.30.81.51.81.2
Condit. Reinf. active minus inactive responses0.50.71.0-0.90.80.70.80.80.70.81.00.8
Condit. Reinf. active-inactive response ratio0.40.40.7-0.70.70.80.70.60.30.80.40.6
Condit. Reinf. active responses0.81.21.6-1.11.11.11.11.10.81.11.31.0
Condit. Reinf. inactive responses1.62.02.8-1.31.41.31.41.51.41.51.71.3
Condit. Reinf. lever presses0.00.00.1-0.20.10.30.10.1-0.20.2-0.00.1
Condit. Reinf. lever reinforcers received0.81.21.5-1.11.11.21.11.10.61.21.21.0
Conditioned reinforcement - actives0.71.24.7-0.60.7-0.20.90.92.20.31.60.9
Conditioned reinforcement - inactives0.00.00.10.00.10.30.10.1-0.20.40.2-0.0
Conditioned locomotion1.31.72.8-1.31.20.71.31.31.41.01.71.4
Patch foraging indifference point 0 sec1.32.44.0-1.51.61.81.51.51.32.01.01.4
Patch foraging indifference point AUC0.00.00.1-0.20.10.10.0-0.00.20.40.30.0
Delay disc. indifference point, 0s delay1.92.12.7-1.51.51.11.51.51.41.61.41.5
Delay disc. indifference point, 16s delay0.70.81.6-0.90.80.50.90.91.30.70.80.9
Delay disc. indifference point, 2s delay2.52.84.6-1.61.71.21.71.72.11.51.71.7
Delay disc. indifference point, 24s delay0.00.00.1-0.20.1-0.30.20.20.30.0-0.00.3
Delay disc. indifference point, 4s delay0.90.91.5-1.11.00.60.90.91.20.90.91.0
Delay disc. indifference point, 8s delay0.30.40.7-0.60.70.40.80.80.40.6-0.00.8
Indifference point function ln k0.00.10.30.00.00.20.10.1-0.3-0.2-0.60.1
Indifference point function log k0.00.10.30.00.00.20.10.1-0.3-0.2-0.60.1
Patch foraging total patch changes 0 sec0.81.53.1-1.21.21.61.21.21.01.80.71.1
Patch foraging total patch changes 12 sec4.45.76.9-2.42.52.32.42.42.42.62.12.3
Patch foraging total patch changes 18 sec0.30.50.8-0.70.60.60.60.60.90.90.80.6
Patch foraging total patch changes 24 sec1.32.32.9-1.71.51.21.51.51.71.21.51.7
Patch foraging total patch changes 6 sec1.32.03.8-1.41.41.91.31.30.82.01.11.2
Patch foraging time to switch 0 sec0.00.00.1-0.10.10.20.10.1-0.10.2-0.00.1
Patch foraging water rate 0 sec0.00.00.4-0.10.10.60.10.1-0.10.2-0.10.0
Patch foraging water rate 12 sec0.20.50.90.6-0.7-1.0-0.7-0.7-0.3-0.9-0.4-0.6
Patch foraging water rate 18 sec0.30.50.9-0.70.80.90.80.80.20.40.30.7
Patch foraging water rate 24 sec0.20.31.0-0.40.61.00.50.60.10.50.30.4
Patch foraging water rate 6 sec0.91.32.7-1.11.21.61.11.10.61.21.11.0
Seeking ratio, delayed vs. immediate footshock0.20.30.80.3-0.3-0.6-0.4-0.40.9-0.30.7-0.5
Distance traveled before self-admin0.10.20.50.6-0.5-0.4-0.5-0.50.1-0.0-0.0-0.7
Distance traveled after self-admin1.11.32.51.4-1.2-0.6-1.2-1.1-1.6-0.8-1.0-1.3
Extensor digitorum longus weight8.131.841.75.8-6.0-6.5-5.8-5.8-4.2-6.1-4.6-5.6
Bone: elastic displacement0.00.00.1-0.30.20.10.20.20.10.2-0.10.2
Bone: elastic work0.00.00.2-0.20.10.40.10.1-0.10.40.00.0
Bone: endosteal estimation1.94.25.22.3-2.2-2.1-2.1-2.1-1.4-1.8-2.0-2.1
Bone: endosteal perimeter1.83.84.92.2-2.1-1.9-2.1-2.1-1.4-1.7-1.9-2.2
Epididymis fat weight0.10.30.50.7-0.5-0.7-0.5-0.50.3-0.60.3-0.5
Delta time in closed arm before/after self-admin5.14.811.02.0-2.0-1.6-2.0-2.0-3.3-2.0-2.3-2.0
Delta time in open arm before/after self-admin0.10.10.4-0.10.1-0.10.10.10.6-0.10.20.1
Diff in mean of infusions in LGA sessions0.40.51.70.8-0.6-0.1-0.6-0.5-1.3-0.4-0.7-0.7
Delay discount exponential model param0.50.50.80.8-0.8-0.5-0.9-0.9-0.7-0.7-0.4-0.9
Extinction: sum of active levers before priming0.60.70.90.9-0.9-0.9-0.8-0.8-0.9-0.8-0.9-0.7
Active lever presses in extinction session 60.20.21.1-0.20.20.60.10.1-0.21.0-0.4-0.0
Bone: final force1.21.92.7-1.31.31.01.41.41.61.31.61.4
Bone: final moment1.01.62.2-1.21.20.91.31.31.51.21.51.3
Food consumed during 24 hour testing period0.71.01.61.0-1.1-1.3-1.0-1.0-0.6-1.1-0.9-0.9
Glucose1.01.54.4-1.00.90.51.01.02.11.01.71.1
Heart weight3.14.85.42.3-2.3-2.2-2.3-2.3-1.9-2.0-2.1-2.3
Delay discount hyperbolic model param0.50.50.70.7-0.8-0.5-0.8-0.8-0.8-0.6-0.4-0.8
Intermittent access intake day 1-15 change0.30.62.60.8-0.50.2-0.6-0.6-1.6-0.5-0.8-0.7
Intermittent access intake escalation0.30.62.20.8-0.50.4-0.6-0.5-1.5-0.6-0.7-0.7
Intermittent access intake escalation 21.01.23.41.0-0.9-0.0-0.9-0.9-1.9-1.1-1.2-1.0
Intermitt. access day 1 inactive lever presses0.20.83.0-0.50.71.70.60.6-1.21.10.00.3
Intermitt. access day 15 inactive lever presses0.71.33.2-1.21.11.81.01.0-0.91.50.40.9
Intermitt. access escalation Index1.21.73.81.1-1.2-1.7-1.1-1.1-0.7-2.0-1.4-0.9
Intermittent access day 1 total infusions0.10.10.50.1-0.0-0.50.00.00.70.10.50.0
Intermittent access day 15 total infusions0.20.30.60.7-0.5-0.2-0.5-0.5-0.7-0.4-0.3-0.6
Intermittent access terminal intake (last 3 days)0.00.00.20.3-0.10.3-0.1-0.1-0.40.10.1-0.2
Intermittent access total infusions0.10.10.30.5-0.4-0.4-0.4-0.4-0.1-0.10.1-0.4
Intermittent access day 1 locomotion0.20.30.9-0.30.3-0.10.40.40.90.60.70.4
Intermittent access day 15 total locomotion0.30.60.7-0.80.80.50.80.80.80.80.80.8
Intermittent access total locomotion1.01.21.6-1.11.10.81.11.21.11.31.21.1
Intermittent access standard deviation0.20.41.3-0.00.31.20.10.2-1.10.80.1-0.1
Left kidney weight1.25.59.62.3-2.3-1.6-2.4-2.4-3.1-2.1-2.4-2.4
Right kidney weight0.20.82.70.7-0.7-0.1-0.8-0.8-1.6-0.7-1.0-0.8
Cocaine induced anxiety4.05.79.52.4-2.3-1.6-2.3-2.3-3.1-1.8-3.0-2.3
Post-drug Anxiety1.51.73.31.3-1.2-0.7-1.2-1.1-1.7-1.1-1.8-1.2
Baseline Anxiety3.94.610.6-2.12.01.12.12.13.31.12.42.2
Tail length1.35.16.82.4-2.4-1.5-2.5-2.5-2.4-1.3-2.4-2.6
Length with tail4.318.722.14.6-4.5-3.5-4.6-4.6-4.3-3.5-4.3-4.7
Length without tail3.110.011.23.3-3.4-3.3-3.3-3.3-2.5-3.1-2.9-3.2
Times rat made contact with spout1.01.11.6-1.31.10.91.11.10.71.10.91.2
Lifetime Intake0.00.10.20.4-0.2-0.1-0.2-0.2-0.00.10.2-0.4
Liver weight, left0.10.20.30.5-0.5-0.4-0.5-0.5-0.4-0.6-0.3-0.5
Liver weight, right0.30.61.5-0.70.81.20.70.70.01.10.40.6
Locomotor activity0.61.01.5-1.01.00.81.01.01.20.81.11.0
Locomotor testing distance2.34.14.9-2.02.11.92.22.22.21.71.82.1
Locomotor testing rearing3.97.811.7-2.92.93.42.82.82.03.32.02.6
Locomotion in novel chamber5.46.910.5-2.92.52.02.42.33.22.92.62.4
Locomotion in novel chamber post-restriction0.20.30.7-0.50.50.80.50.50.30.70.10.4
Fecal boli incidents, locomotor time 10.10.20.40.3-0.4-0.4-0.4-0.4-0.7-0.1-0.5-0.4
Change in fecal boli incidents, locomotor task0.40.41.4-0.50.60.20.60.71.20.30.70.7
Time >=10cm from walls, locomotor time 10.90.92.9-0.80.90.10.90.91.70.81.00.9
Bouts of movement, locomotor time 10.91.02.70.9-0.8-0.5-0.8-0.8-1.7-1.0-1.3-0.8
Total resting periods, locomotor time 11.11.22.51.1-1.0-0.7-0.9-0.9-1.6-1.3-1.3-0.9
Rest time, locomotor task time 10.20.31.90.2-0.20.5-0.2-0.2-1.4-0.2-0.6-0.2
Distance moved, locomotor task time 10.30.52.8-0.30.3-0.30.40.31.70.31.10.3
Vertical activity count, locomotor time 10.10.31.10.3-0.3-1.0-0.3-0.21.0-0.20.2-0.3
Time >=10cm from walls, locomotor time 22.43.514.8-1.51.40.11.51.53.81.32.01.5
Bouts of movement, locomotor time 20.00.10.2-0.20.30.40.30.3-0.30.3-0.10.2
Total resting periods, locomotor time 20.10.10.60.10.00.2-0.00.0-0.80.0-0.4-0.1
Rest time, locomotor task time 21.31.63.81.1-1.2-0.8-1.2-1.2-1.9-0.8-1.5-1.2
Distance moved, locomotor task time 20.10.21.0-0.10.10.00.10.11.00.30.50.0
Vertical activity count, locomotor time 20.10.10.20.3-0.3-0.5-0.2-0.20.4-0.2-0.1-0.2
Light reinforcement 11.02.55.0-1.51.72.21.61.60.52.00.91.4
Light reinforcement 20.60.92.2-0.91.01.50.90.90.11.20.60.8
Bone: marrow area1.84.05.02.2-2.1-2.0-2.1-2.1-1.5-1.7-2.0-2.1
Bone: maximum diameter0.00.00.20.1-0.0-0.1-0.00.00.30.00.4-0.0
Bone: maximum force0.00.00.10.00.1-0.00.10.10.40.10.40.1
Bone: maximum moment0.00.00.10.1-0.0-0.20.00.00.3-0.10.20.0
Mean time between licks in bursts1.02.32.61.6-1.6-1.3-1.6-1.6-1.6-1.5-1.5-1.6
Mean num. licks in bursts0.00.10.1-0.10.10.40.00.1-0.20.4-0.4-0.0
Cd content in liver1.61.82.51.5-1.3-1.1-1.3-1.3-1.3-1.3-1.6-1.3
Co content in liver2.32.62.91.7-1.7-1.5-1.7-1.7-1.4-1.7-1.6-1.7
Cu content in liver0.50.61.30.7-0.70.2-0.9-0.9-1.20.0-0.9-1.0
Fe content in liver1.72.02.61.5-1.6-1.3-1.6-1.6-1.2-1.0-1.4-1.6
K content in liver0.20.20.6-0.40.30.60.20.20.20.80.30.2
Mg content in liver0.20.20.6-0.60.50.50.40.40.30.70.40.4
Mn content in liver0.30.31.1-0.40.41.00.30.30.21.00.30.2
Na content in liver0.20.20.3-0.50.50.40.40.40.40.60.50.5
Rb content in liver1.82.14.3-1.41.41.81.31.30.92.11.11.2
Se content in liver4.25.08.0-2.22.22.82.12.11.62.82.01.9
Sr content in liver1.10.91.21.0-1.0-0.8-1.0-1.0-1.1-0.7-0.9-1.0
Zn content in liver1.82.04.3-1.41.52.11.41.40.51.71.11.2
Bone: minimum diameter0.40.71.11.0-1.0-0.9-1.0-0.9-0.2-0.5-0.6-1.0
Time in familiar zone, hab. session 10.50.41.1-0.60.60.40.70.70.80.51.10.6
Time in novel zone, hab. session 10.60.61.0-0.80.81.00.80.80.30.90.20.9
Total zone transitions, hab. session 12.13.03.31.8-1.8-1.6-1.8-1.8-1.6-1.8-1.4-1.8
Total locomotion distance, hab. session 10.00.10.10.2-0.2-0.1-0.2-0.2-0.3-0.3-0.3-0.2
Locomotion velocity, hab. session 10.60.91.11.0-1.0-0.9-1.0-0.9-0.8-1.0-1.0-1.0
Time in familiar zone, hab. session 20.50.50.8-0.60.70.90.70.70.50.80.60.6
Time in novel zone, hab. session 20.00.00.1-0.20.20.30.20.2-0.20.2-0.00.2
Total zone transitions, hab. session 20.60.81.01.0-0.9-0.7-0.9-0.9-0.8-0.7-0.8-1.0
Total locomotion distance, hab. session 20.20.20.60.5-0.4-0.2-0.4-0.4-0.6-0.5-0.8-0.4
Locomotion velocity, hab. session 20.40.50.70.8-0.7-0.6-0.7-0.7-0.5-0.8-0.8-0.7
Novel to familiar place preference ratio1.51.62.91.2-1.3-1.7-1.2-1.3-0.7-1.6-1.2-1.1
Novelty place preference1.11.22.71.0-1.0-1.6-1.0-1.0-0.3-1.5-0.8-0.8
Time in novel zone, NPP test0.40.41.40.5-0.5-1.2-0.5-0.50.2-1.1-0.4-0.3
Total zone transitions, NPP test0.20.30.50.7-0.7-0.4-0.7-0.7-0.4-0.4-0.2-0.7
Total locomotion distance, NPP test0.00.00.2-0.00.10.40.00.0-0.20.2-0.1-0.0
Locomotion velocity, NPP test0.30.40.70.6-0.6-0.3-0.7-0.6-0.8-0.5-0.7-0.7
Intraocular pressure1.82.74.41.7-1.6-1.9-1.5-1.5-1.2-2.1-1.5-1.4
Delta distance traveled before/after self-admin1.01.12.11.0-0.9-0.8-0.9-0.9-1.5-1.1-1.2-0.8
Delta ambulatory time before/after self-admin0.70.82.90.8-0.7-0.5-0.6-0.6-1.7-1.0-1.2-0.4
Parametrial fat weight0.30.61.0-0.70.91.00.90.90.40.80.60.8
Pavlov. Cond. lever latency2.63.34.41.8-1.9-2.1-1.9-1.9-1.1-1.9-1.8-1.8
Pavlov. Cond. magazine entry latency9.712.513.6-3.73.73.63.63.62.83.53.63.5
Pavlov. Cond. change in total contacts9.29.711.2-3.33.33.33.23.22.33.13.13.1
Pavlov. Cond. index score9.111.512.6-3.53.53.63.53.52.63.53.43.4
Pavlov. Cond. latency score7.19.010.1-3.13.13.23.13.12.33.03.03.0
Pavlov. Cond. lever contacts3.33.94.9-2.02.12.22.02.01.32.02.01.9
Pavlov. Cond. magazine entry number14.017.719.44.4-4.4-4.3-4.3-4.3-3.4-4.2-4.1-4.3
Pavlov. Cond. intertrial magazine entries1.31.61.81.3-1.3-1.2-1.3-1.3-1.1-1.1-1.3-1.3
Pavlov. Cond. lever-magazine prob. diff.10.713.314.5-3.83.83.83.73.82.83.73.63.6
Pavlov. Cond. response bias10.713.314.6-3.83.83.83.73.72.83.73.73.6
Pavlov. Cond. lever latency0.30.30.50.7-0.6-0.6-0.6-0.6-0.2-0.5-0.5-0.6
Pavlov. Cond. magazine entry latency0.10.10.30.0-0.1-0.5-0.1-0.10.1-0.50.4-0.0
Pavlov. Cond. change in total contacts0.40.61.1-0.80.80.70.80.80.50.81.10.7
Pavlov. Cond. index score0.20.20.4-0.60.50.30.50.40.20.20.60.5
Pavlov. Cond. latency score0.10.20.4-0.50.40.20.40.40.30.10.60.5
Pavlov. Cond. lever contacts0.40.60.8-0.90.80.70.80.80.50.70.70.8
Pavlov. Cond. magazine entry number0.20.20.80.5-0.5-0.4-0.5-0.4-0.1-0.2-0.9-0.5
Pavlov. Cond. intertrial magazine entries1.72.63.31.7-1.6-1.8-1.6-1.6-1.1-1.8-1.6-1.5
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.40.30.20.30.30.00.10.50.3
Pavlov. Cond. response bias0.81.01.4-1.21.10.91.11.00.70.91.21.1
Time in closed arm before self-admin1.62.14.9-1.31.52.21.41.40.81.51.31.3
Time in closed arm after self-admin0.50.62.50.6-0.60.1-0.7-0.6-1.6-0.4-0.7-0.7
Time in open arm before self-admin2.22.44.41.5-1.7-2.1-1.7-1.7-0.8-1.2-1.4-1.6
Time in open arm after self-admin0.30.30.80.5-0.6-0.9-0.6-0.60.2-0.5-0.5-0.6
Bone: periosteal estimation0.20.30.60.7-0.7-0.7-0.6-0.6-0.1-0.5-0.4-0.6
Bone: periosteal perimeter0.61.11.41.2-1.2-1.1-1.1-1.1-0.7-1.1-0.6-1.2
Bone: post-yield work1.01.42.11.2-1.2-1.0-1.1-1.1-1.5-1.4-0.9-1.1
Progressive ratio test 1 active lever presses0.40.52.0-0.40.50.00.60.61.40.60.90.7
Progressive ratio test 1 breakpoint0.40.41.7-0.30.5-0.00.60.61.30.50.80.6
Progressive ratio test 1 inactive lever presses0.10.10.60.10.10.50.00.1-0.80.4-0.1-0.1
Progressive ratio test 2 active lever presses0.81.02.5-0.70.70.50.70.71.51.01.60.7
Progressive ratio test 2 breakpoint0.91.12.7-0.80.80.50.80.81.61.11.60.7
Progressive ratio test 2 inactive lever presses0.10.10.30.1-0.20.1-0.3-0.3-0.50.50.1-0.4
Incentive Sensitization - Responses0.91.33.1-1.01.00.70.90.91.51.31.70.8
Incentive Sensitization - Breakpoint0.91.12.7-1.00.90.60.80.81.41.21.70.7
Sum of active levers in priming session hrs 5-60.20.20.7-0.40.40.40.40.40.30.80.40.4
Progressive ratio0.00.10.20.1-0.0-0.0-0.1-0.10.30.50.4-0.3
Food seeking constrained by brief footshock0.40.51.1-0.60.71.00.70.70.20.90.40.7
Seeking ratio, punishment vs. effort0.10.20.5-0.40.40.30.50.5-0.1-0.2-0.10.7
Retroperitoneal fat weight0.10.30.6-0.30.50.70.60.60.50.80.40.5
Reaction time number correct0.61.23.21.1-1.1-1.8-1.1-1.10.2-1.3-0.4-1.0
Reaction time mean minus median0.10.20.70.4-0.4-0.2-0.3-0.3-0.8-0.8-0.6-0.2
Reaction time mean minus median AUC0.10.20.5-0.50.50.30.60.60.2-0.10.40.7
Reaction time num false alarms0.71.01.6-0.90.90.70.90.91.30.91.20.9
Reaction time num false alarms AUC0.40.61.2-0.70.80.50.80.81.00.61.10.8
Reaction time trials correct on left0.61.23.21.1-1.1-1.8-1.1-1.10.2-1.3-0.4-1.0
Reaction time trials on left0.61.13.11.0-1.1-1.8-1.0-1.00.2-1.2-0.3-1.0
Reaction time mean0.10.10.7-0.30.20.50.20.1-0.90.0-0.30.2
Reaction time mean AUC0.10.21.1-0.20.10.50.10.0-1.00.0-0.40.1
Median of all reaction times0.30.40.9-0.80.60.90.60.5-0.50.60.10.6
Reaction time omissions0.20.30.9-0.50.60.90.60.6-0.20.30.30.6
Reaction time false alarm rate1.11.51.8-1.21.31.31.31.30.91.11.21.2
Reaction time premature initiation rate0.10.20.3-0.30.50.30.50.50.30.20.10.5
Reaction time premature initiations0.10.20.80.5-0.4-0.9-0.4-0.30.1-0.7-0.4-0.3
Std. dev. reaction times0.10.10.5-0.10.10.40.10.1-0.7-0.3-0.20.2
Reaction time trials completed0.61.13.11.0-1.1-1.8-1.0-1.00.2-1.2-0.3-1.0
Reaction time trials AUC0.51.03.10.9-1.0-1.8-0.9-0.90.3-1.2-0.2-0.9
Run reversals in cocaine runway, females1.61.63.01.3-1.4-1.7-1.3-1.3-0.9-1.3-1.0-1.2
Run reversals in cocaine runway, males0.30.30.5-0.70.50.10.50.50.70.70.40.6
Latency to leave start box in cocaine runway2.02.33.41.6-1.7-1.6-1.7-1.7-1.0-1.3-0.9-1.8
Latency to leave start box in cocaine runway, F2.63.05.41.8-1.9-2.3-1.9-1.9-0.4-1.8-0.7-1.9
Latency to leave start box in cocaine runway, M0.40.41.60.2-0.20.7-0.4-0.4-1.30.5-0.6-0.6
Std. dev. time between licks in bursts0.30.41.40.4-0.5-0.1-0.6-0.6-1.2-0.5-0.8-0.5
Total sessions with >9 infusions0.00.00.20.10.00.30.00.00.20.30.4-0.1
Short access day 1 total inactive lever presses0.81.12.9-0.91.11.71.01.0-0.01.10.90.7
Short access day 10 total inactive lever presses0.61.35.90.9-0.80.1-0.9-0.9-2.4-0.5-1.3-1.0
Short access day 1 total infusions0.10.10.6-0.20.30.50.20.20.20.80.50.0
Short access day 10 total infusions0.20.30.5-0.40.50.40.50.50.60.60.70.4
Short access total infusions0.00.10.20.10.00.2-0.0-0.00.20.50.4-0.1
Short access day 1 locomotion0.70.92.0-0.80.91.40.90.90.11.40.80.7
Short access day 10 total locomotion1.73.23.8-1.81.81.61.91.91.61.91.61.9
Short access total locomotion0.30.30.9-0.40.50.60.50.50.50.90.60.4
One hour access (0.3 mA shock)0.20.30.90.5-0.3-0.8-0.2-0.11.0-0.60.5-0.1
Compulsive drug intake0.20.21.1-0.20.2-0.30.40.31.1-0.00.40.5
One hour access (shock baseline)0.10.20.40.6-0.5-0.4-0.5-0.4-0.3-0.3-0.0-0.6
Social response proportion0.00.00.1-0.00.00.30.00.0-0.0-0.10.10.0
Social responses0.20.31.7-0.30.41.30.30.3-0.20.80.20.1
Social time0.00.00.10.0-0.00.1-0.1-0.1-0.1-0.1-0.3-0.1
Soleus weight0.41.22.0-1.11.10.41.21.21.20.51.31.4
Bone: stiffness0.00.10.30.00.0-0.20.10.10.50.00.60.1
Tibialis anterior weight1.34.35.52.0-2.1-2.2-2.1-2.1-2.0-2.3-2.0-1.9
Time to tail flick, vehicle, before self-admin0.20.20.7-0.40.50.80.50.5-0.30.00.10.5
Time to tail flick, vehicle, after self-admin0.10.10.2-0.30.2-0.20.30.20.50.0-0.00.3
Time to tail flick, test, before self-admin0.70.71.50.9-0.8-0.9-0.7-0.7-0.6-1.2-1.1-0.6
Time to tail flick, test, after self-admin0.20.20.8-0.30.40.90.30.3-0.50.7-0.10.3
Delta time to tail flick, vehicle, before/after SA0.60.61.8-0.70.6-0.20.60.61.30.70.70.7
Delta time to tail flick, test, before/after SA2.62.75.0-1.71.61.71.51.51.32.21.61.4
Tibia length0.71.93.21.4-1.4-1.8-1.4-1.4-0.6-1.7-1.2-1.2
Ambulatory time before self-admin0.30.51.10.8-0.8-0.5-0.9-0.8-0.5-0.2-0.4-1.0
Ambulatory time after self-admin2.93.47.62.0-1.8-0.9-1.8-1.7-2.8-1.4-1.9-1.9
Bone: tissue strength0.60.61.50.7-0.7-1.0-0.6-0.7-0.6-1.2-0.5-0.5
Total heroin consumption0.80.92.2-1.00.91.30.80.80.71.50.70.7
Bone: trabecular number5.28.611.6-3.03.13.43.03.02.13.02.62.9
Bone: trabecular spacing1.11.52.81.3-1.3-1.7-1.2-1.2-0.5-1.5-0.9-1.1
Bone: trabecular thickness0.00.10.2-0.20.20.50.20.1-0.30.10.20.1
Bone: trabecular tissue density0.00.00.00.1-0.1-0.2-0.1-0.1-0.00.0-0.2-0.0
Water consumed over 24 hours0.10.10.30.1-0.1-0.5-0.1-0.10.4-0.4-0.20.0
Number of responses in last shaping day0.20.31.40.1-0.10.7-0.2-0.2-1.20.4-0.4-0.3