Hub : Genes

Sspn

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS NM_001109255.2 0.09 0.07 3.0e-09 0.1 0.1 0.11 0.1 1.5e-09 9.4e-10 1.2e-10 1.5e-09
2 Brain alternative TSS XM_017592843.3 0.07 0.05 2.3e-07 0.07 0.08 0.09 0.08 1.9e-07 8.9e-08 5.9e-09 1.2e-07
3 PL alternative TSS NM_001109255.2 0.02 0.02 3.7e-03 0.01 0.01 0.01 0.01 9.8e-03 1.2e-02 3.0e-02 5.0e-02
4 BLA alternative TSS XM_017592843.3 0.05 0.05 4.8e-03 0.04 0.04 0.02 0.04 3.1e-03 3.2e-03 2.9e-02 5.7e-03
5 BLA gene expression Sspn 0.38 0.15 0.0e+00 0.36 0.33 0.34 0.34 7.2e-20 2.9e-18 8.7e-19 1.6e-18
6 IC alternative TSS XM_017592843.3 0.09 0.07 9.4e-04 0.03 0 0.05 0.02 1.8e-02 2.1e-01 3.3e-03 3.6e-02
7 IC alternative TSS NM_001109255.2 0.08 0.07 3.1e-03 0.03 0 0.04 0.03 2.7e-02 2.9e-01 1.4e-02 2.1e-02
8 NAcc gene expression Sspn 0.42 0.17 0.0e+00 0.47 0.48 0.48 0.48 5.6e-80 2.5e-83 2.2e-83 1.9e-83
9 NAcc alternative TSS XM_039108232.2 0.04 0.03 6.5e-07 0.04 0.04 0.04 0.04 3.4e-07 4.3e-07 1.9e-06 9.2e-07
10 pVTA alternative TSS NM_001109255.2 0.04 0.03 1.4e-03 0.03 0.03 0.02 0.03 2.6e-03 3.4e-03 5.8e-03 3.8e-03
11 RMTg alternative TSS NM_001109255.2 0.17 0.16 4.5e-03 0.09 0.11 0.05 0.03 2.4e-03 6.7e-04 2.3e-02 7.1e-02
12 OFC gene expression Sspn 0.47 0.2 2.1e-08 0.18 0.23 0.19 0.2 5.3e-05 3.6e-06 3.3e-05 1.4e-05
13 Adipose isoform ratio XM_039108233.2 0.02 0.02 5.3e-03 0.01 0 0 0 2.5e-02 7.2e-02 1.1e-01 8.5e-02
14 BLA alternative TSS NM_001109255.2 0.07 0.07 1.9e-03 0.04 0.05 0.03 0.04 2.2e-03 1.6e-03 1.2e-02 3.7e-03
15 pVTA alternative TSS XM_017592843.3 0.03 0.03 6.5e-03 0.02 0.02 0.01 0.01 1.1e-02 7.1e-03 2.2e-02 1.9e-02
16 NAcc alternative TSS NM_001109255.2 0.02 0.01 1.9e-03 0.01 0.02 0.01 0.01 6.4e-03 8.6e-04 6.0e-03 7.6e-03
17 PL alternative TSS XM_039108232.2 0.04 0.03 1.1e-05 0.04 0.04 0.04 0.04 1.7e-05 1.4e-05 2.4e-05 1.4e-05
18 RMTg gene expression Sspn 0.29 0.14 1.4e-07 0.25 0.1 0.26 0.08 2.4e-07 1.5e-03 1.2e-07 3.4e-03
19 pVTA gene expression Sspn 0.62 0.19 0.0e+00 0.55 0.21 0.57 0.19 3.5e-52 1.9e-16 7.0e-55 3.5e-15
20 PL gene expression Sspn 0.41 0.15 0.0e+00 0.42 0.44 0.43 0.44 1.1e-49 2.2e-52 2.0e-51 2.8e-52
21 IC gene expression Sspn 0.5 0.17 0.0e+00 0.38 0.01 0.37 0.09 6.3e-17 1.3e-01 2.0e-16 9.7e-05
22 Brain gene expression Sspn 0.42 0.11 0.0e+00 0.58 0.6 0.6 0.6 1.4e-66 3.2e-69 3.6e-69 6.8e-69
23 IL gene expression Sspn 0.38 0.18 8.2e-09 0.32 0.31 0.3 0.31 1.4e-08 3.0e-08 5.6e-08 2.6e-08
24 LHb gene expression Sspn 0.57 0.18 2.9e-14 0.45 0.25 0.42 0.24 5.7e-12 1.4e-06 2.5e-11 2.0e-06
25 Brain alternative TSS NM_001109255.2 0.03 0.03 1.9e-03 0.04 0.03 0.03 0 1.5e-04 1.5e-03 3.7e-04 1.2e-01
26 IL alternative TSS XM_039108232.2 0.33 0.21 2.3e-04 0.17 0.15 0.14 0.07 6.0e-05 2.1e-04 3.7e-04 1.1e-02
27 NAcc intron excision ratio chr4_180628106_180652111 0.04 0.03 3.8e-07 0.04 0.04 0.04 0.04 3.0e-07 4.9e-07 6.6e-07 6.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27
Bone: apparent density0.00.10.20.0-0.10.1-0.40.1-0.40.4-0.2-0.10.4-0.2-0.30.3-0.20.3-0.30.30.30.3-0.30.3-0.30.10.1-0.00.00.3
Area under the delay curve1.01.52.4-1.11.3-1.21.5-1.21.3-1.21.21.3-1.21.21.2-1.41.3-1.21.2-1.2-1.3-1.31.3-1.31.3-1.3-1.3-0.20.2-1.1
BMI with tail5.920.632.05.7-5.64.7-4.54.8-4.24.1-4.6-4.64.6-4.6-4.54.6-4.64.5-4.54.54.64.4-4.44.5-4.44.44.44.1-4.13.9
BMI without tail2.312.214.92.9-3.13.5-3.53.6-3.83.9-3.6-3.63.6-3.7-3.63.8-3.33.6-3.53.53.63.4-3.53.5-3.43.53.53.1-3.13.4
Body weight1.25.37.22.5-2.72.5-2.42.6-2.32.3-2.4-2.52.4-2.4-2.32.3-2.32.3-2.32.22.32.2-2.32.2-2.32.22.21.8-1.82.1
Weight adjusted by age0.51.42.2-1.00.70.8-0.30.7-1.31.3-1.2-1.21.5-1.2-1.31.3-1.01.3-1.21.41.31.3-1.31.4-1.21.41.40.9-0.91.3
Bone surface0.40.82.30.2-0.30.8-0.90.8-1.51.5-0.9-0.81.0-0.9-1.00.9-0.61.0-0.91.00.90.8-0.90.9-0.80.80.80.7-0.70.9
Bone volume0.40.72.30.1-0.10.7-1.00.7-1.51.5-0.8-0.71.0-0.9-1.00.8-0.51.0-0.80.90.80.8-0.90.8-0.70.70.70.8-0.80.9
Breakpoint value in progressive ratio session0.30.61.2-0.90.30.6-0.40.4-0.50.5-0.8-0.71.1-0.7-0.70.8-0.60.7-0.70.90.90.9-0.80.9-0.80.60.60.9-0.90.8
Number of licking bursts0.00.00.20.5-0.40.1-0.10.10.4-0.4-0.00.0-0.10.10.1-0.1-0.2-0.10.0-0.1-0.10.00.1-0.1-0.00.00.00.1-0.1-0.1
Context. condit. distance diff. score0.70.81.1-0.70.6-0.80.7-0.91.1-1.10.80.8-0.91.01.0-1.00.8-1.00.9-0.9-0.9-0.80.9-0.90.9-0.9-0.9-0.90.9-1.0
Locomotion velocity, session 10.00.00.10.3-0.2-0.10.1-0.1-0.00.10.1-0.0-0.30.10.1-0.10.2-0.10.2-0.2-0.2-0.30.2-0.20.3-0.0-0.00.3-0.3-0.3
Locomotion distance, session 10.20.30.5-0.50.4-0.60.4-0.60.4-0.30.50.5-0.70.60.6-0.50.7-0.60.6-0.7-0.6-0.70.6-0.70.7-0.5-0.5-0.30.3-0.6
Locomotion velocity, session 21.11.31.5-1.21.2-1.21.1-1.21.0-0.91.11.2-1.21.11.1-1.11.2-1.11.1-1.1-1.1-1.21.1-1.11.2-1.1-1.1-1.01.0-1.1
Locomotion distance, session 20.30.50.9-0.60.6-0.70.5-0.70.00.10.70.7-0.80.60.6-0.70.9-0.60.7-0.7-0.7-0.90.7-0.70.9-0.6-0.6-0.70.7-0.7
Locomotion velocity, session 30.00.00.10.3-0.40.2-0.30.2-0.20.2-0.2-0.30.1-0.2-0.20.2-0.20.2-0.20.20.20.2-0.20.2-0.20.20.20.1-0.10.0
Locomotion distance, session 30.10.10.20.4-0.30.3-0.30.3-0.50.5-0.3-0.30.2-0.3-0.30.1-0.10.2-0.20.10.20.1-0.20.1-0.10.20.20.1-0.10.2
Stereotopy head waving bouts, day 30.00.00.4-0.1-0.1-0.0-0.0-0.00.6-0.60.00.1-0.00.10.10.1-0.2-0.1-0.00.10.10.10.00.1-0.1-0.0-0.00.2-0.20.1
Stereotopy head waving duration, day 30.10.10.9-0.20.0-0.30.3-0.40.9-1.00.30.3-0.40.40.4-0.30.1-0.40.3-0.3-0.3-0.20.4-0.30.2-0.3-0.3-0.10.1-0.3
Locomotion velocity, session 70.70.81.2-1.00.8-0.81.1-0.80.7-0.60.80.7-1.00.90.9-0.91.1-0.91.0-1.0-0.9-1.01.0-1.01.0-0.9-0.9-0.80.8-1.1
Locomotion distance, session 71.82.33.5-1.91.8-1.41.7-1.51.2-1.21.41.4-1.51.51.5-1.41.6-1.51.5-1.5-1.5-1.51.5-1.51.5-1.5-1.5-1.61.6-1.5
Stereotopy head waving bouts, day 72.02.34.5-0.30.4-1.51.5-1.32.1-2.11.51.5-1.61.61.7-1.71.2-1.71.6-1.6-1.6-1.51.6-1.61.4-1.6-1.6-1.21.2-1.6
Stereotopy head waving duration, day 71.11.32.90.00.1-1.11.0-1.01.6-1.71.21.1-1.21.21.3-1.30.8-1.31.2-1.2-1.2-1.11.2-1.21.0-1.2-1.2-0.90.9-1.2
Locomotion velocity, session 80.10.10.2-0.20.2-0.20.2-0.3-0.00.10.20.3-0.40.20.2-0.30.4-0.30.3-0.3-0.3-0.40.3-0.30.4-0.2-0.2-0.20.2-0.4
Locomotion distance, session 81.92.83.4-1.41.3-1.61.4-1.71.3-1.21.71.7-1.81.71.7-1.81.9-1.71.8-1.8-1.8-1.91.8-1.81.8-1.8-1.8-1.61.6-1.8
Degree of sensitization distance1.41.51.8-1.31.3-1.21.3-1.31.3-1.21.21.2-1.21.31.3-1.21.3-1.21.3-1.2-1.2-1.21.2-1.21.2-1.2-1.2-1.21.2-1.2
Degree of sensitization stereotypy1.61.82.7-0.20.3-1.31.2-1.21.6-1.61.41.3-1.51.41.5-1.51.2-1.51.4-1.5-1.4-1.41.5-1.51.3-1.4-1.4-1.01.0-1.4
Conditioned locomotion0.60.70.90.8-0.90.8-1.00.8-0.40.3-0.8-0.90.8-0.7-0.70.8-1.00.7-0.80.80.80.9-0.90.9-0.90.90.90.8-0.80.8
Cocaine response after cond. corrected0.40.71.2-0.80.9-0.80.9-0.90.9-1.00.80.8-0.60.80.8-0.80.7-0.80.7-0.7-0.7-0.60.7-0.70.7-0.9-0.9-1.11.1-0.7
Cocaine response after cond. not corrected0.20.30.8-0.70.7-0.60.6-0.60.5-0.50.50.6-0.40.60.5-0.50.5-0.50.5-0.5-0.5-0.50.5-0.50.5-0.6-0.6-0.90.9-0.5
Cocaine response before conditioning1.21.51.71.2-1.21.2-1.31.2-1.31.3-1.2-1.21.1-1.2-1.21.2-1.21.2-1.21.11.21.1-1.21.1-1.21.21.21.2-1.21.3
Saline control response0.20.20.40.4-0.30.4-0.70.5-0.40.4-0.4-0.40.4-0.5-0.50.6-0.60.5-0.50.40.50.5-0.50.5-0.50.60.60.3-0.30.4
Bone: connectivity density0.00.00.3-0.00.00.2-0.10.1-0.50.5-0.2-0.10.3-0.2-0.30.2-0.10.3-0.20.20.20.2-0.20.2-0.10.10.10.1-0.10.2
Bone: cortical apparent density0.50.92.51.6-1.51.1-1.31.0-0.50.5-0.9-1.00.8-0.8-0.70.8-1.00.7-0.80.60.80.8-0.80.7-0.90.90.91.1-1.10.8
Bone: cortical area2.64.24.71.5-1.72.1-2.02.1-2.22.1-2.1-2.12.2-2.1-2.12.1-2.02.2-2.12.12.12.1-2.12.1-2.12.12.11.7-1.72.1
Bone: cortical porosity0.30.30.60.3-0.40.4-0.80.5-0.70.7-0.5-0.50.7-0.6-0.60.5-0.50.6-0.60.70.60.6-0.60.7-0.60.50.50.2-0.20.7
Bone: cortical porosity0.60.60.90.6-0.70.7-1.00.7-0.80.8-0.8-0.80.9-0.8-0.80.8-0.80.8-0.80.90.80.9-0.80.9-0.80.80.80.4-0.41.0
Bone: cortical thickness2.23.64.21.7-1.82.0-2.02.0-1.71.7-2.0-2.01.9-1.9-1.92.0-2.01.9-2.01.92.02.0-2.01.9-2.02.02.01.4-1.42.0
Bone: cortical thickness0.00.00.1-0.0-0.1-0.00.0-0.10.3-0.40.0-0.00.00.10.1-0.1-0.1-0.10.0-0.0-0.10.10.0-0.0-0.00.00.0-0.20.20.0
Bone: cortical tissue density0.50.72.41.6-1.41.0-1.20.9-0.40.3-0.8-0.90.7-0.7-0.70.7-1.00.7-0.70.60.70.7-0.70.6-0.80.80.81.0-1.00.7
Condit. Reinf. active minus inactive responses0.70.72.10.6-0.70.8-1.00.8-1.41.4-0.8-0.80.9-0.9-0.90.9-0.60.9-0.80.90.90.7-0.80.9-0.70.80.80.7-0.70.8
Condit. Reinf. active-inactive response ratio0.60.61.90.5-0.60.7-0.90.7-1.31.4-0.7-0.70.8-0.8-0.90.7-0.50.9-0.70.80.80.7-0.80.8-0.60.70.70.3-0.30.7
Condit. Reinf. active responses1.11.41.91.0-1.11.2-1.31.2-1.41.4-1.2-1.21.2-1.2-1.21.2-1.01.2-1.11.21.21.1-1.21.2-1.11.11.11.1-1.11.1
Condit. Reinf. inactive responses0.40.51.10.7-0.80.8-0.70.8-0.40.4-0.8-0.90.6-0.7-0.70.7-0.80.7-0.70.70.70.7-0.70.7-0.70.80.81.0-1.00.7
Incentive salience index mean0.81.02.51.1-1.01.0-1.11.0-1.51.6-0.9-0.90.9-1.0-1.00.9-0.71.0-0.90.90.90.8-0.90.9-0.70.80.81.0-1.00.8
Condit. Reinf. lever presses0.40.51.41.1-0.90.7-0.70.8-1.11.2-0.6-0.60.6-0.7-0.70.5-0.40.7-0.60.50.50.4-0.50.5-0.40.60.61.1-1.10.5
Condit. Reinf. active minus inactive responses0.00.00.10.1-0.0-0.10.2-0.10.3-0.40.20.1-0.20.10.2-0.20.0-0.20.1-0.2-0.2-0.20.2-0.20.1-0.1-0.10.1-0.1-0.1
Condit. Reinf. active-inactive response ratio0.50.80.9-0.70.8-0.90.9-0.90.8-0.80.90.9-1.00.90.9-0.90.9-0.90.9-1.0-0.9-0.90.9-1.00.9-0.9-0.9-0.70.7-0.9
Condit. Reinf. active responses0.10.10.40.5-0.40.3-0.10.4-0.10.0-0.3-0.40.2-0.3-0.30.3-0.40.3-0.30.20.30.3-0.30.2-0.40.30.30.6-0.60.3
Condit. Reinf. inactive responses1.62.43.01.6-1.61.6-1.41.6-1.21.1-1.6-1.61.5-1.5-1.51.6-1.71.5-1.61.51.61.6-1.61.5-1.61.61.61.7-1.71.6
Condit. Reinf. lever presses1.11.62.21.5-1.41.2-1.31.3-0.80.7-1.2-1.21.3-1.2-1.21.2-1.41.2-1.31.31.31.4-1.21.3-1.31.21.21.4-1.41.3
Condit. Reinf. lever reinforcers received0.40.51.00.9-0.90.7-0.60.8-0.50.5-0.7-0.70.6-0.7-0.70.7-0.80.7-0.70.60.70.7-0.70.6-0.70.70.71.0-1.00.7
Conditioned reinforcement - actives0.51.92.40.7-0.61.4-1.41.2-1.51.5-1.3-1.41.3-1.4-1.51.5-1.31.5-1.41.51.41.4-1.51.5-1.41.51.51.4-1.41.5
Conditioned reinforcement - inactives0.10.30.80.4-0.40.9-0.50.6-0.30.3-0.5-0.30.4-0.5-0.50.6-0.60.5-0.50.50.50.5-0.50.5-0.60.50.50.5-0.50.5
Conditioned locomotion1.62.44.12.0-1.91.7-0.91.6-1.31.2-1.5-1.51.4-1.6-1.51.5-1.61.5-1.51.51.41.5-1.51.5-1.51.51.51.9-1.91.5
Patch foraging indifference point 0 sec0.20.61.5-1.20.9-0.60.5-0.61.2-1.20.50.4-0.60.80.8-0.50.4-0.80.6-0.6-0.6-0.40.6-0.60.5-0.6-0.6-1.21.2-0.6
Patch foraging indifference point AUC0.30.84.12.0-2.00.8-0.80.7-0.50.4-0.8-0.80.7-0.7-0.70.7-0.90.7-0.80.70.70.9-0.80.7-0.80.60.60.4-0.41.0
Delay disc. indifference point, 0s delay0.70.81.6-0.60.6-0.81.3-0.71.2-1.10.90.8-1.00.80.9-0.90.9-0.90.9-0.9-0.9-1.11.1-1.01.0-0.8-0.8-0.10.1-0.8
Delay disc. indifference point, 16s delay0.10.10.3-0.10.3-0.40.1-0.50.2-0.20.40.5-0.40.40.4-0.40.4-0.40.4-0.4-0.5-0.40.4-0.40.4-0.5-0.50.2-0.2-0.4
Delay disc. indifference point, 2s delay1.31.42.2-1.21.3-1.21.5-1.11.4-1.31.21.2-1.31.21.2-1.21.2-1.21.2-1.2-1.2-1.31.3-1.31.2-1.1-1.1-0.50.5-1.1
Delay disc. indifference point, 24s delay0.20.30.6-0.60.6-0.70.3-0.80.1-0.20.50.6-0.30.60.5-0.60.6-0.50.5-0.3-0.6-0.40.4-0.40.5-0.6-0.6-0.20.2-0.5
Delay disc. indifference point, 4s delay0.40.51.2-0.91.1-0.71.1-0.60.7-0.70.70.6-0.60.60.6-0.80.7-0.60.6-0.5-0.7-0.70.7-0.70.7-0.6-0.60.1-0.1-0.4
Delay disc. indifference point, 8s delay0.30.52.0-0.81.0-0.61.4-0.60.9-0.90.70.6-0.60.60.6-0.70.7-0.60.7-0.7-0.6-0.70.8-0.60.7-0.6-0.60.2-0.2-0.5
Indifference point function ln k0.41.22.5-1.51.6-1.01.1-1.01.0-0.91.11.1-1.21.11.1-1.01.1-1.11.1-1.1-1.0-1.21.1-1.01.1-1.0-1.0-0.70.7-1.1
Indifference point function log k0.41.22.5-1.51.6-1.01.1-1.01.0-0.91.11.1-1.21.11.1-1.01.1-1.11.1-1.1-1.0-1.21.1-1.01.1-1.0-1.0-0.70.7-1.1
Patch foraging total patch changes 0 sec0.41.12.4-1.61.2-0.90.9-1.01.5-1.50.80.7-0.91.11.1-0.90.8-1.11.0-0.9-0.9-0.70.9-0.90.8-0.9-0.9-1.51.5-0.9
Patch foraging total patch changes 12 sec1.01.43.3-0.1-0.2-1.10.9-1.11.6-1.71.00.9-1.11.21.2-1.30.8-1.21.1-1.1-1.1-0.91.0-1.20.9-1.3-1.3-1.81.8-0.9
Patch foraging total patch changes 18 sec0.00.10.50.4-0.70.3-0.30.20.2-0.2-0.2-0.50.2-0.1-0.10.2-0.30.1-0.20.10.10.3-0.20.2-0.20.20.2-0.40.40.4
Patch foraging total patch changes 24 sec0.00.10.80.7-0.90.1-0.20.00.3-0.3-0.1-0.20.10.00.0-0.0-0.2-0.0-0.10.00.10.2-0.10.0-0.1-0.1-0.1-0.20.20.1
Patch foraging total patch changes 6 sec0.20.41.30.2-0.2-0.60.3-0.51.1-1.10.50.5-0.50.70.7-0.50.3-0.70.5-0.5-0.5-0.30.5-0.60.4-0.6-0.6-1.01.0-0.4
Patch foraging time to switch 0 sec0.20.81.2-0.70.9-0.90.9-0.80.6-0.61.00.9-0.90.80.9-0.91.0-0.90.9-1.0-0.9-1.11.0-1.01.0-0.9-0.9-0.60.6-0.9
Patch foraging water rate 0 sec0.00.10.30.2-0.50.5-0.30.30.1-0.2-0.5-0.50.4-0.3-0.30.4-0.50.3-0.40.40.40.6-0.40.4-0.50.40.4-0.00.00.2
Patch foraging water rate 12 sec0.20.81.40.5-0.71.0-0.90.9-0.70.6-1.0-1.20.9-0.9-0.91.0-0.90.9-0.90.91.01.0-1.00.9-1.01.11.10.6-0.61.0
Patch foraging water rate 18 sec1.12.43.10.9-1.11.6-1.41.4-1.41.4-1.7-1.61.6-1.6-1.61.5-1.51.6-1.61.71.71.7-1.71.8-1.61.61.61.6-1.61.6
Patch foraging water rate 24 sec0.10.20.40.2-0.30.6-0.20.4-0.10.1-0.5-0.60.5-0.4-0.40.4-0.40.4-0.40.50.50.5-0.40.5-0.40.50.50.5-0.50.4
Patch foraging water rate 6 sec1.72.63.81.3-1.52.0-1.71.6-1.21.1-1.8-1.81.7-1.5-1.61.5-1.71.6-1.61.81.71.8-1.71.8-1.71.61.61.3-1.31.6
Seeking ratio, delayed vs. immediate footshock0.71.01.81.2-1.21.4-1.01.3-0.60.5-1.1-1.10.7-1.0-0.90.9-1.20.9-1.00.80.80.9-1.00.9-1.10.90.90.9-0.91.1
Distance traveled before self-admin0.71.69.33.0-2.51.4-0.81.5-0.60.6-1.1-0.90.8-1.1-0.90.8-1.20.9-0.90.80.90.7-0.70.7-0.90.80.81.9-1.90.7
Distance traveled after self-admin0.50.910.83.3-2.70.9-0.61.1-0.40.4-0.5-0.40.3-0.7-0.50.5-0.60.4-0.40.30.50.1-0.10.2-0.30.50.51.0-1.00.3
Extensor digitorum longus weight1.66.58.02.2-2.52.6-2.72.6-2.82.8-2.6-2.62.6-2.6-2.62.5-2.42.6-2.52.52.52.5-2.52.6-2.42.62.62.3-2.32.5
Bone: elastic displacement2.43.03.51.4-1.51.7-1.81.7-1.91.9-1.7-1.71.7-1.8-1.81.8-1.61.8-1.71.81.81.7-1.81.8-1.71.71.71.6-1.61.8
Bone: elastic work4.45.79.01.7-1.82.3-2.32.4-2.93.0-2.4-2.42.4-2.5-2.52.4-2.12.5-2.42.42.42.3-2.42.4-2.22.32.32.4-2.42.4
Bone: endosteal estimation0.10.20.6-0.80.6-0.50.7-0.4-0.00.10.40.4-0.20.30.3-0.40.6-0.30.4-0.3-0.4-0.40.4-0.30.5-0.5-0.5-0.20.2-0.5
Bone: endosteal perimeter0.00.10.4-0.20.10.10.00.2-0.60.6-0.2-0.10.4-0.3-0.30.3-0.00.3-0.20.40.20.2-0.20.3-0.10.10.10.2-0.2-0.1
Epididymis fat weight0.21.23.11.7-1.81.3-1.01.2-0.90.9-1.2-1.21.0-1.1-1.01.2-1.11.0-1.01.00.91.0-1.01.0-1.01.01.00.8-0.80.8
Delta time in closed arm before/after self-admin0.50.41.61.3-1.30.5-0.90.5-0.80.8-0.6-0.40.5-0.5-0.50.4-0.50.5-0.50.50.40.5-0.50.4-0.40.50.51.0-1.00.5
Delta time in open arm before/after self-admin4.65.48.1-2.72.8-2.22.6-2.32.5-2.62.22.1-2.22.32.3-2.22.1-2.32.3-2.3-2.2-2.22.2-2.32.2-2.2-2.2-2.42.4-2.3
Diff in mean of infusions in LGA sessions0.10.11.1-1.00.50.1-0.10.0-0.10.1-0.3-0.30.4-0.2-0.30.4-0.30.3-0.30.50.50.4-0.40.4-0.30.10.10.1-0.10.5
Delay discount exponential model param1.21.62.51.2-1.51.3-1.61.3-1.21.2-1.3-1.31.3-1.2-1.21.4-1.41.2-1.31.21.31.4-1.41.3-1.41.31.30.3-0.31.1
Extinction: sum of active levers before priming0.20.30.8-0.50.20.6-0.60.4-0.10.0-0.7-0.60.9-0.5-0.50.6-0.70.5-0.60.70.90.8-0.70.7-0.70.60.60.3-0.30.5
Active lever presses in extinction session 60.20.20.8-0.1-0.10.4-0.50.3-0.20.2-0.6-0.50.9-0.4-0.40.5-0.50.4-0.50.60.70.6-0.40.5-0.50.40.40.5-0.50.4
Bone: final force1.93.03.71.3-1.51.8-1.71.8-1.91.8-1.8-1.81.9-1.8-1.81.8-1.71.8-1.81.91.81.8-1.81.8-1.71.71.71.6-1.61.6
Bone: final moment2.23.54.01.4-1.62.0-1.81.9-2.02.0-1.9-1.92.0-1.9-1.91.9-1.81.9-1.92.01.91.9-1.91.9-1.81.81.81.7-1.71.8
Food consumed during 24 hour testing period3.97.89.31.8-1.92.7-2.82.7-2.72.7-2.8-2.73.0-2.8-2.93.0-2.82.9-2.93.03.03.1-3.03.0-2.93.03.02.5-2.52.9
Glucose2.84.47.32.2-2.12.2-2.02.1-2.72.7-2.1-2.02.0-2.2-2.21.9-1.82.2-2.02.02.01.9-2.02.0-1.91.91.92.3-2.32.0
Heart weight2.43.85.21.6-1.82.0-1.92.1-1.81.8-2.0-2.32.0-2.0-2.01.9-1.92.0-2.01.92.02.0-2.02.0-2.02.02.01.9-1.91.9
Delay discount hyperbolic model param1.11.42.41.2-1.51.2-1.51.2-1.21.1-1.2-1.21.2-1.1-1.11.3-1.31.1-1.21.21.21.3-1.31.2-1.31.21.20.2-0.21.0
Intermittent access intake day 1-15 change0.00.10.7-0.90.7-0.2-0.4-0.2-0.20.2-0.2-0.20.6-0.1-0.20.4-0.20.3-0.30.40.40.5-0.40.4-0.40.30.3-0.20.20.3
Intermittent access intake escalation0.10.30.7-0.90.70.0-0.7-0.1-0.50.5-0.4-0.30.8-0.4-0.40.6-0.40.5-0.50.70.60.7-0.60.6-0.60.60.6-0.00.00.6
Intermittent access intake escalation 20.00.10.3-0.50.60.10.0-0.20.2-0.3-0.1-0.10.4-0.1-0.10.3-0.20.1-0.20.20.30.4-0.30.2-0.30.30.3-0.20.20.2
Intermitt. access day 1 inactive lever presses0.00.54.92.2-1.61.20.21.10.1-0.1-0.3-0.1-0.2-0.4-0.30.0-0.50.2-0.20.00.0-0.10.10.0-0.10.10.11.2-1.2-0.0
Intermitt. access day 15 inactive lever presses0.00.21.91.4-1.10.7-0.20.40.2-0.3-0.10.1-0.2-0.10.0-0.0-0.4-0.0-0.1-0.0-0.00.00.1-0.0-0.1-0.0-0.00.7-0.70.1
Intermitt. access escalation Index0.10.40.6-0.70.8-0.70.5-0.80.5-0.40.70.6-0.40.70.6-0.50.7-0.60.6-0.6-0.6-0.60.6-0.60.6-0.6-0.6-0.70.7-0.7
Intermittent access day 1 total infusions0.00.10.80.8-0.90.2-0.20.3-0.40.4-0.1-0.1-0.1-0.1-0.1-0.1-0.00.1-0.0-0.0-0.1-0.10.0-0.10.0-0.1-0.10.5-0.50.0
Intermittent access day 15 total infusions0.10.30.6-0.0-0.20.3-0.80.2-0.80.8-0.6-0.50.6-0.5-0.50.6-0.40.6-0.60.70.60.6-0.60.6-0.60.50.50.3-0.30.6
Intermittent access terminal intake (last 3 days)0.20.40.60.5-0.70.6-0.80.4-0.70.7-0.6-0.70.7-0.5-0.60.6-0.60.6-0.60.70.60.7-0.70.6-0.60.50.50.5-0.50.6
Intermittent access total infusions1.51.83.31.7-1.81.4-1.41.3-1.61.7-1.3-1.31.2-1.3-1.31.2-1.11.3-1.21.31.21.1-1.21.2-1.11.11.11.4-1.41.2
Intermittent access day 1 locomotion0.81.414.13.8-3.61.3-0.81.2-0.30.3-0.8-0.70.3-0.6-0.50.3-0.90.5-0.50.40.40.4-0.30.3-0.50.40.41.2-1.20.4
Intermittent access day 15 total locomotion0.72.87.42.7-2.71.7-1.41.7-1.31.3-1.7-1.71.6-1.6-1.51.6-1.71.5-1.61.61.51.6-1.51.6-1.61.51.51.7-1.71.5
Intermittent access total locomotion2.63.115.33.9-3.72.0-1.61.9-1.41.5-1.6-1.51.2-1.5-1.41.3-1.51.4-1.41.31.31.2-1.21.3-1.31.31.32.0-2.01.2
Intermittent access standard deviation0.21.26.22.5-2.51.4-0.71.2-0.40.4-1.1-1.00.8-0.9-0.80.9-1.10.8-0.90.80.80.8-0.80.7-0.90.70.71.1-1.10.8
Left kidney weight0.00.42.1-1.41.3-0.60.4-0.60.1-0.00.50.6-0.30.50.4-0.30.6-0.40.5-0.4-0.4-0.40.4-0.40.5-0.6-0.6-0.80.8-0.4
Right kidney weight0.10.52.1-1.41.3-0.60.5-0.70.1-0.00.70.7-0.40.60.5-0.40.8-0.50.6-0.5-0.5-0.60.5-0.50.6-0.7-0.7-1.11.1-0.5
Cocaine induced anxiety1.02.76.1-2.42.5-1.72.2-1.51.7-1.81.71.6-1.51.51.5-1.51.4-1.51.5-1.5-1.5-1.41.5-1.51.4-1.5-1.5-1.51.5-1.5
Post-drug Anxiety0.80.94.7-2.22.1-1.21.3-0.91.0-1.10.80.8-0.60.80.7-0.60.7-0.70.7-0.6-0.7-0.60.6-0.60.6-0.7-0.7-0.70.7-0.6
Baseline Anxiety0.50.81.40.5-0.60.6-1.20.7-0.80.8-1.1-1.01.1-0.9-0.91.0-0.90.9-0.91.01.01.0-1.01.0-1.01.01.00.9-0.91.0
Tail length1.26.322.1-4.74.1-2.62.2-2.61.5-1.32.32.3-2.22.32.2-2.22.8-2.22.4-2.3-2.3-2.42.2-2.42.5-2.2-2.2-2.52.5-2.0
Length with tail0.94.110.7-3.33.0-2.11.9-2.01.3-1.21.91.9-1.92.01.9-2.02.3-1.92.0-2.0-2.1-2.01.9-2.02.1-2.0-2.0-1.91.9-1.7
Length without tail0.00.20.50.4-0.1-0.40.5-0.30.4-0.40.50.6-0.50.50.5-0.70.4-0.50.5-0.6-0.7-0.50.6-0.50.5-0.6-0.6-0.30.3-0.5
Times rat made contact with spout1.01.21.6-0.90.9-1.01.2-1.11.2-1.21.11.1-1.11.11.1-1.01.0-1.11.1-1.1-1.0-1.01.0-1.01.0-1.0-1.0-1.31.3-1.1
Lifetime Intake1.01.22.61.2-1.41.1-1.21.1-1.51.6-1.0-1.01.1-1.1-1.10.9-0.91.1-1.01.11.00.9-1.01.0-0.90.90.91.3-1.31.0
Liver weight, left0.30.51.61.3-1.30.7-0.60.8-0.70.7-0.7-0.70.7-0.7-0.70.6-0.60.7-0.70.60.60.6-0.60.6-0.60.60.60.7-0.70.6
Liver weight, right2.54.36.22.5-2.52.2-2.02.3-1.81.7-2.1-2.22.1-2.0-2.02.1-2.12.0-2.12.12.12.2-2.12.2-2.11.91.91.8-1.82.0
Locomotor activity4.57.08.51.3-1.42.8-2.22.6-2.52.3-2.8-2.92.9-2.7-2.82.8-2.72.8-2.82.92.72.9-2.92.8-2.82.92.92.3-2.32.8
Locomotor testing distance1.84.46.00.7-0.92.3-1.72.2-1.61.4-2.3-2.32.1-2.1-2.22.3-2.32.2-2.32.22.22.4-2.42.1-2.42.42.41.8-1.82.3
Locomotor testing rearing0.20.61.0-0.40.20.9-0.50.8-0.50.4-0.9-0.80.9-0.8-0.80.9-0.90.8-0.90.80.81.0-1.00.7-1.00.90.90.7-0.71.0
Locomotion in novel chamber1.82.43.50.7-1.01.5-1.81.4-1.41.4-1.6-1.61.6-1.5-1.61.9-1.51.6-1.61.61.51.6-1.61.6-1.61.81.81.3-1.31.5
Locomotion in novel chamber post-restriction0.30.83.4-1.91.4-1.10.8-1.10.3-0.30.81.0-0.60.90.8-0.91.0-0.80.8-0.8-1.0-0.80.7-0.70.8-0.9-0.9-0.90.9-0.6
Fecal boli incidents, locomotor time 10.40.91.8-0.50.7-1.11.0-1.00.7-0.71.01.0-1.30.91.0-0.91.0-1.01.0-1.2-0.8-1.21.0-1.01.1-0.9-0.9-0.80.8-1.2
Change in fecal boli incidents, locomotor task0.30.30.8-0.40.30.5-0.30.4-0.90.9-0.6-0.60.9-0.6-0.70.4-0.40.7-0.60.80.40.6-0.70.7-0.50.50.50.3-0.30.7
Time >=10cm from walls, locomotor time 10.10.10.3-0.60.5-0.30.0-0.4-0.10.20.20.1-0.50.30.2-0.40.4-0.20.3-0.3-0.3-0.40.2-0.30.4-0.4-0.4-0.40.4-0.3
Bouts of movement, locomotor time 13.14.17.2-2.42.7-2.02.3-1.91.7-1.62.02.2-2.02.01.9-2.02.2-1.92.0-1.9-2.1-2.02.0-2.02.1-2.0-2.0-1.81.8-2.0
Total resting periods, locomotor time 14.34.98.3-2.62.9-2.12.5-2.11.8-1.82.22.4-2.22.22.1-2.22.4-2.12.2-2.1-2.3-2.22.2-2.22.3-2.2-2.2-2.02.0-2.2
Rest time, locomotor task time 10.10.21.2-0.91.1-0.30.5-0.4-0.20.20.30.4-0.30.30.3-0.30.7-0.30.4-0.3-0.4-0.40.3-0.30.5-0.2-0.2-0.30.3-0.5
Distance moved, locomotor task time 10.10.21.91.4-1.40.4-0.60.5-0.10.1-0.3-0.40.3-0.3-0.30.2-0.60.3-0.40.20.20.2-0.20.1-0.40.20.20.4-0.40.5
Vertical activity count, locomotor time 10.00.20.90.5-0.4-0.20.5-0.10.9-1.00.30.1-0.40.40.4-0.5-0.1-0.40.3-0.5-0.4-0.40.4-0.50.2-0.4-0.4-0.30.3-0.2
Time >=10cm from walls, locomotor time 20.20.71.2-0.80.9-0.90.2-1.10.4-0.20.80.8-0.90.80.8-0.90.9-0.80.9-0.8-1.0-1.00.8-1.00.9-0.9-0.9-0.90.9-0.6
Bouts of movement, locomotor time 20.82.84.9-1.91.7-1.72.2-1.61.7-1.71.71.6-1.81.61.6-1.71.6-1.71.7-1.6-1.6-1.71.8-1.51.7-1.8-1.8-1.11.1-1.7
Total resting periods, locomotor time 20.83.05.9-2.01.8-1.72.4-1.61.9-1.81.71.6-1.81.71.7-1.81.7-1.71.7-1.7-1.7-1.71.8-1.61.7-1.8-1.8-1.11.1-1.8
Rest time, locomotor task time 21.52.55.8-2.42.2-1.52.1-1.61.4-1.41.41.4-1.21.51.4-1.51.6-1.41.4-1.4-1.4-1.31.3-1.21.4-1.3-1.3-2.02.0-1.6
Distance moved, locomotor task time 21.21.63.01.7-1.51.2-1.61.3-1.11.1-1.1-1.21.1-1.2-1.21.3-1.31.1-1.21.21.21.0-1.11.0-1.21.21.21.3-1.31.4
Vertical activity count, locomotor time 20.10.10.80.9-0.70.3-0.60.3-0.0-0.0-0.3-0.40.1-0.3-0.20.4-0.50.2-0.30.20.30.2-0.20.1-0.30.40.40.5-0.50.3
Light reinforcement 10.00.22.6-1.61.2-0.4-0.5-0.6-0.30.40.10.20.10.10.00.10.30.00.0-0.00.20.1-0.20.10.00.10.1-0.20.20.2
Light reinforcement 21.12.49.2-3.02.7-1.71.3-1.80.6-0.51.51.6-1.31.41.3-1.41.9-1.31.5-1.4-1.4-1.51.4-1.31.6-1.3-1.3-1.31.3-1.3
Bone: marrow area0.00.10.4-0.60.5-0.30.6-0.3-0.20.20.30.3-0.10.20.1-0.20.5-0.10.2-0.1-0.3-0.30.3-0.20.4-0.4-0.4-0.00.0-0.4
Bone: maximum diameter2.55.16.31.6-1.72.3-2.22.2-2.52.5-2.3-2.32.3-2.3-2.42.3-2.12.4-2.32.32.32.2-2.32.3-2.22.32.32.2-2.22.3
Bone: maximum force1.12.12.70.8-1.01.4-1.31.4-1.61.6-1.5-1.51.6-1.5-1.61.5-1.31.6-1.51.61.51.5-1.51.6-1.41.41.41.3-1.31.4
Bone: maximum moment1.32.53.31.0-1.21.6-1.51.6-1.81.8-1.6-1.61.7-1.7-1.71.6-1.51.7-1.61.81.61.6-1.61.7-1.51.61.61.4-1.41.6
Mean time between licks in bursts0.00.20.70.3-0.3-0.40.2-0.40.8-0.80.40.4-0.50.50.5-0.50.1-0.50.4-0.5-0.4-0.30.4-0.40.3-0.4-0.4-0.50.5-0.3
Mean num. licks in bursts0.20.51.7-1.31.2-0.80.9-0.80.4-0.40.70.7-0.60.60.6-0.60.8-0.60.6-0.6-0.6-0.60.6-0.60.7-0.7-0.7-0.90.9-0.5
Cd content in liver0.00.00.4-0.30.30.10.00.1-0.60.6-0.1-0.10.1-0.2-0.20.10.10.2-0.10.10.0-0.0-0.10.10.00.10.10.0-0.00.1
Co content in liver7.08.28.7-2.52.6-2.92.6-2.92.7-2.62.92.9-2.92.92.9-2.92.9-2.92.9-2.9-2.9-2.92.9-2.92.9-2.9-2.9-2.82.8-2.8
Cu content in liver0.00.00.30.5-0.50.1-0.30.10.2-0.2-0.1-0.10.1-0.0-0.00.1-0.30.0-0.10.10.10.2-0.10.1-0.20.10.10.0-0.00.1
Fe content in liver0.00.10.40.3-0.30.0-0.10.00.6-0.7-0.1-0.10.10.10.10.1-0.3-0.1-0.00.10.10.2-0.00.1-0.20.10.1-0.30.3-0.0
K content in liver0.10.10.60.0-0.1-0.30.3-0.30.7-0.80.30.2-0.20.30.3-0.20.1-0.30.2-0.2-0.2-0.10.2-0.20.1-0.2-0.2-0.70.7-0.3
Mg content in liver0.80.91.5-0.70.7-0.91.0-0.91.2-1.20.90.9-0.91.01.0-0.90.8-1.00.9-0.9-0.9-0.80.9-0.90.8-0.9-0.9-1.21.2-0.9
Mn content in liver0.10.11.00.4-0.3-0.10.1-0.10.9-1.00.10.1-0.10.30.3-0.1-0.2-0.30.1-0.1-0.10.10.1-0.1-0.1-0.1-0.1-0.60.6-0.1
Na content in liver0.91.01.81.3-1.31.0-0.81.0-0.40.3-1.0-1.11.1-0.9-0.91.1-1.20.9-1.01.11.11.1-1.01.1-1.11.11.10.7-0.70.8
Rb content in liver1.82.02.71.3-1.41.4-1.71.4-1.61.6-1.4-1.41.4-1.4-1.51.4-1.41.5-1.41.41.41.4-1.41.4-1.41.41.41.3-1.31.5
Se content in liver1.51.82.1-1.11.2-1.41.3-1.41.3-1.31.41.4-1.41.41.4-1.41.4-1.41.4-1.4-1.4-1.41.4-1.41.4-1.4-1.4-1.21.2-1.4
Sr content in liver0.30.30.8-0.20.3-0.50.6-0.50.8-0.90.50.5-0.50.60.6-0.50.4-0.60.5-0.5-0.5-0.50.5-0.50.4-0.5-0.5-0.40.4-0.6
Zn content in liver0.20.20.5-0.70.7-0.40.3-0.4-0.20.40.40.4-0.40.30.3-0.40.7-0.30.4-0.4-0.4-0.60.4-0.40.6-0.4-0.4-0.50.5-0.5
Bone: minimum diameter0.00.10.4-0.1-0.00.20.10.3-0.60.6-0.2-0.20.3-0.3-0.30.2-0.00.3-0.20.30.20.1-0.20.2-0.10.10.10.1-0.10.1
Time in familiar zone, hab. session 10.00.00.2-0.40.3-0.0-0.0-0.1-0.10.1-0.00.00.1-0.0-0.00.10.00.0-0.00.10.10.1-0.10.1-0.0-0.0-0.0-0.20.20.1
Time in novel zone, hab. session 10.00.00.50.7-0.50.1-0.10.10.0-0.0-0.1-0.10.0-0.1-0.1-0.1-0.10.1-0.10.00.00.0-0.00.0-0.10.10.10.2-0.20.0
Total zone transitions, hab. session 10.10.10.3-0.10.0-0.30.0-0.30.5-0.50.20.2-0.30.30.4-0.30.2-0.40.3-0.3-0.3-0.30.3-0.30.2-0.2-0.2-0.30.3-0.3
Total locomotion distance, hab. session 10.10.10.4-0.40.4-0.30.2-0.30.6-0.70.20.2-0.10.30.3-0.20.1-0.30.2-0.2-0.1-0.00.2-0.20.1-0.2-0.2-0.40.4-0.2
Locomotion velocity, hab. session 10.00.00.1-0.30.20.0-0.0-0.00.1-0.2-0.1-0.00.10.0-0.00.1-0.10.0-0.10.10.10.2-0.10.1-0.10.10.1-0.00.00.1
Time in familiar zone, hab. session 20.20.30.4-0.60.6-0.60.5-0.60.5-0.50.50.5-0.60.50.5-0.60.6-0.50.5-0.5-0.5-0.50.5-0.50.5-0.5-0.5-0.40.4-0.4
Time in novel zone, hab. session 20.20.21.01.0-0.80.5-0.30.5-0.20.2-0.4-0.40.3-0.4-0.30.4-0.40.3-0.40.30.30.3-0.30.3-0.40.30.30.3-0.30.2
Total zone transitions, hab. session 20.00.00.1-0.30.1-0.1-0.2-0.10.0-0.0-0.0-0.10.00.00.00.00.0-0.0-0.0-0.00.00.0-0.0-0.0-0.00.10.10.0-0.00.0
Total locomotion distance, hab. session 20.00.00.3-0.50.4-0.10.1-0.10.1-0.2-0.00.00.10.10.00.1-0.1-0.0-0.00.00.10.1-0.10.0-0.10.00.0-0.10.10.1
Locomotion velocity, hab. session 20.00.00.4-0.60.5-0.10.0-0.10.1-0.1-0.0-0.00.10.0-0.00.1-0.10.0-0.10.10.10.1-0.10.1-0.10.10.1-0.10.10.2
Novel to familiar place preference ratio0.10.10.30.00.1-0.20.4-0.2-0.00.10.30.4-0.20.20.2-0.30.4-0.20.3-0.2-0.3-0.30.3-0.20.3-0.3-0.3-0.50.5-0.3
Novelty place preference0.00.10.20.10.1-0.20.3-0.2-0.10.10.20.3-0.20.10.1-0.20.3-0.10.2-0.2-0.2-0.30.2-0.20.3-0.3-0.3-0.50.5-0.3
Time in novel zone, NPP test0.00.00.20.4-0.30.2-0.00.2-0.30.4-0.1-0.10.1-0.2-0.20.1-0.00.2-0.10.10.10.1-0.10.1-0.10.10.1-0.20.20.0
Total zone transitions, NPP test0.10.10.30.3-0.40.3-0.50.3-0.30.4-0.4-0.40.3-0.3-0.30.4-0.30.3-0.30.30.40.3-0.30.3-0.30.40.40.5-0.50.4
Total locomotion distance, NPP test0.00.00.5-0.70.6-0.20.2-0.30.0-0.00.10.1-0.10.10.10.00.2-0.10.1-0.1-0.0-0.10.1-0.10.1-0.1-0.1-0.10.1-0.1
Locomotion velocity, NPP test0.10.20.9-0.90.8-0.50.5-0.50.3-0.30.40.4-0.40.40.4-0.30.5-0.40.4-0.4-0.3-0.40.4-0.40.4-0.4-0.4-0.40.4-0.3
Intraocular pressure0.91.52.3-1.10.9-1.30.9-1.40.7-0.51.31.3-1.31.21.2-1.31.5-1.21.3-1.2-1.3-1.31.3-1.21.4-1.3-1.3-1.11.1-1.4
Delta distance traveled before/after self-admin0.00.10.40.6-0.60.0-0.10.1-0.20.30.10.1-0.2-0.00.0-0.00.2-0.00.1-0.1-0.0-0.20.2-0.10.2-0.1-0.1-0.40.4-0.0
Delta ambulatory time before/after self-admin0.20.30.80.1-0.0-0.50.3-0.40.3-0.10.70.6-0.70.50.6-0.60.7-0.60.6-0.6-0.6-0.70.7-0.60.7-0.6-0.6-0.90.9-0.5
Parametrial fat weight0.30.61.50.2-0.10.7-0.80.8-1.21.2-0.7-0.70.8-0.9-0.90.8-0.60.9-0.80.70.80.7-0.80.8-0.71.01.00.7-0.70.6
Pavlov. Cond. lever latency0.10.11.4-1.20.8-0.20.3-0.3-0.00.00.10.1-0.10.10.1-0.10.2-0.10.1-0.1-0.0-0.10.1-0.10.1-0.1-0.1-0.20.2-0.0
Pavlov. Cond. magazine entry latency0.10.10.30.10.1-0.40.4-0.30.1-0.00.40.5-0.40.30.3-0.40.5-0.40.4-0.5-0.5-0.50.5-0.50.5-0.4-0.4-0.00.0-0.5
Pavlov. Cond. change in total contacts0.00.00.70.9-0.60.10.00.20.1-0.10.00.0-0.1-0.00.0-0.0-0.1-0.00.0-0.1-0.1-0.10.1-0.10.0-0.0-0.00.2-0.2-0.1
Pavlov. Cond. index score0.00.10.70.9-0.60.1-0.10.2-0.10.1-0.00.0-0.0-0.1-0.00.0-0.10.0-0.0-0.0-0.1-0.00.0-0.00.0-0.0-0.00.4-0.4-0.1
Pavlov. Cond. latency score0.00.10.60.8-0.4-0.10.00.10.1-0.00.20.2-0.20.10.1-0.20.1-0.10.2-0.2-0.2-0.20.2-0.20.2-0.2-0.20.2-0.2-0.3
Pavlov. Cond. lever contacts0.20.32.11.5-1.10.5-0.50.7-0.30.3-0.4-0.40.4-0.4-0.40.4-0.50.4-0.40.40.30.4-0.40.4-0.40.40.40.5-0.50.3
Pavlov. Cond. magazine entry number0.00.00.1-0.20.20.10.1-0.00.3-0.4-0.0-0.10.00.10.1-0.0-0.1-0.1-0.00.00.00.1-0.00.0-0.10.00.0-0.30.30.0
Pavlov. Cond. intertrial magazine entries2.83.44.41.9-1.92.0-1.71.9-1.41.3-1.9-2.11.8-1.8-1.81.8-2.01.8-1.91.91.91.9-1.91.9-1.91.91.91.5-1.51.9
Pavlov. Cond. lever-magazine prob. diff.0.10.11.01.0-0.70.2-0.20.3-0.10.1-0.1-0.10.1-0.1-0.10.1-0.20.1-0.10.10.00.1-0.00.1-0.10.10.10.4-0.40.0
Pavlov. Cond. response bias0.10.10.70.8-0.60.2-0.30.3-0.40.4-0.2-0.10.2-0.2-0.20.2-0.20.2-0.20.20.10.2-0.20.2-0.20.10.10.4-0.40.2
Pavlov. Cond. lever latency0.71.02.6-1.61.5-1.01.1-1.00.5-0.50.91.0-0.90.90.9-0.91.1-0.90.9-0.9-0.9-1.00.9-1.01.0-1.0-1.0-0.80.8-1.0
Pavlov. Cond. magazine entry latency1.01.54.11.0-1.11.1-1.51.1-1.92.0-1.1-1.11.1-1.3-1.31.1-0.81.3-1.11.11.10.9-1.11.1-0.91.11.11.1-1.11.2
Pavlov. Cond. change in total contacts1.33.15.02.2-2.21.8-2.01.8-1.71.7-1.7-1.71.7-1.7-1.71.6-1.71.7-1.71.71.71.7-1.71.7-1.71.71.71.7-1.71.7
Pavlov. Cond. index score1.11.72.81.7-1.61.3-1.61.3-1.41.5-1.2-1.21.2-1.3-1.31.2-1.21.3-1.21.21.21.2-1.21.2-1.21.21.21.3-1.31.3
Pavlov. Cond. latency score1.01.72.71.6-1.61.2-1.61.3-1.41.4-1.2-1.21.2-1.3-1.31.2-1.21.3-1.21.21.21.2-1.21.2-1.21.21.21.3-1.31.3
Pavlov. Cond. lever contacts0.81.12.61.6-1.51.0-1.21.1-0.70.7-1.0-1.01.0-1.0-1.01.0-1.11.0-1.01.11.01.1-1.01.1-1.11.01.01.0-1.01.0
Pavlov. Cond. magazine entry number2.02.65.1-1.71.7-1.52.0-1.52.1-2.31.51.5-1.51.61.7-1.51.3-1.61.5-1.5-1.5-1.31.5-1.51.3-1.5-1.5-1.51.5-1.5
Pavlov. Cond. intertrial magazine entries0.20.30.90.9-0.80.8-0.00.80.0-0.1-0.6-0.80.6-0.5-0.50.5-0.80.5-0.60.50.50.6-0.50.5-0.60.50.50.6-0.60.5
Pavlov. Cond. lever-magazine prob. diff.1.01.62.61.6-1.61.2-1.61.2-1.41.5-1.1-1.21.1-1.2-1.21.1-1.11.2-1.21.21.21.1-1.11.2-1.11.21.21.2-1.21.2
Pavlov. Cond. response bias0.60.82.01.4-1.30.9-1.20.9-0.91.0-0.8-0.90.8-0.9-0.90.8-0.80.9-0.80.90.90.8-0.80.9-0.80.90.90.7-0.70.9
Time in closed arm before self-admin0.10.22.3-1.51.2-0.2-0.1-0.5-0.30.40.1-0.0-0.10.10.00.10.30.00.10.10.1-0.1-0.10.00.10.10.1-0.60.60.0
Time in closed arm after self-admin0.60.73.41.8-1.70.8-1.50.7-1.11.2-0.7-0.60.6-0.7-0.70.6-0.60.7-0.60.70.50.6-0.60.7-0.60.60.60.6-0.60.7
Time in open arm before self-admin0.80.91.61.0-1.30.9-0.31.1-0.60.6-1.1-1.01.0-1.0-1.00.9-1.11.0-1.01.11.01.0-0.90.9-1.00.90.91.0-1.01.1
Time in open arm after self-admin1.11.24.5-2.11.9-1.21.3-1.01.3-1.40.90.8-0.91.00.9-0.80.8-0.90.9-0.9-0.9-0.80.9-0.90.8-0.8-0.8-1.21.2-0.8
Bone: periosteal estimation0.51.22.20.6-0.71.1-0.81.1-1.51.5-1.1-1.11.3-1.2-1.21.1-0.91.2-1.11.21.11.1-1.11.2-1.01.01.01.0-1.01.0
Bone: periosteal perimeter0.20.51.4-0.1-0.10.6-0.40.6-1.21.2-0.7-0.60.8-0.8-0.80.7-0.40.8-0.70.80.70.6-0.70.7-0.60.60.60.5-0.50.6
Bone: post-yield work0.30.50.8-0.90.8-0.70.9-0.70.5-0.50.70.6-0.60.70.6-0.70.8-0.60.7-0.6-0.7-0.70.7-0.70.7-0.7-0.7-0.80.8-0.8
Progressive ratio test 1 active lever presses0.30.51.51.1-1.20.7-1.00.5-1.11.2-0.6-0.50.5-0.6-0.60.4-0.40.6-0.50.60.50.5-0.50.5-0.40.40.40.6-0.60.4
Progressive ratio test 1 breakpoint0.20.41.41.1-1.20.6-0.90.5-1.01.1-0.5-0.40.5-0.5-0.50.3-0.40.5-0.50.50.40.4-0.50.5-0.40.30.30.6-0.60.4
Progressive ratio test 1 inactive lever presses0.00.10.90.9-0.70.40.20.10.3-0.30.10.4-0.40.10.2-0.20.0-0.20.2-0.3-0.3-0.40.3-0.40.2-0.3-0.30.2-0.2-0.2
Progressive ratio test 2 active lever presses0.00.10.40.6-0.60.4-0.30.3-0.30.4-0.2-0.10.1-0.2-0.20.1-0.10.2-0.20.20.10.1-0.10.1-0.10.10.10.2-0.20.1
Progressive ratio test 2 breakpoint0.10.10.50.7-0.60.5-0.30.3-0.40.4-0.3-0.20.2-0.3-0.30.1-0.20.3-0.20.30.20.2-0.20.2-0.20.10.10.3-0.30.2
Progressive ratio test 2 inactive lever presses0.20.61.20.8-0.81.1-0.70.7-0.60.5-0.9-0.60.7-0.8-0.80.8-0.90.8-0.80.80.80.8-0.80.8-0.80.80.81.0-1.00.8
Incentive Sensitization - Responses0.10.20.5-0.40.5-0.20.7-0.30.6-0.60.40.5-0.50.40.4-0.40.4-0.40.4-0.5-0.5-0.50.5-0.50.4-0.4-0.4-0.50.5-0.4
Incentive Sensitization - Breakpoint0.10.20.4-0.30.5-0.20.6-0.30.5-0.50.40.4-0.40.30.3-0.30.3-0.30.3-0.4-0.4-0.40.4-0.40.3-0.3-0.3-0.40.4-0.3
Sum of active levers in priming session hrs 5-60.20.22.9-1.71.2-0.3-0.2-0.4-0.20.2-0.2-0.10.5-0.1-0.20.20.00.2-0.20.30.30.3-0.30.3-0.20.10.1-0.40.40.2
Progressive ratio1.02.94.11.7-2.01.7-1.61.7-1.81.8-1.7-1.71.6-1.7-1.71.7-1.61.7-1.71.61.61.6-1.71.6-1.61.71.71.6-1.61.8
Food seeking constrained by brief footshock0.00.00.10.2-0.30.3-0.10.1-0.20.2-0.2-0.30.0-0.1-0.10.0-0.20.1-0.10.10.10.1-0.20.1-0.1-0.1-0.10.4-0.40.2
Seeking ratio, punishment vs. effort0.51.11.4-0.91.2-0.90.9-1.11.1-1.11.01.0-1.01.11.1-1.11.0-1.11.1-1.1-1.0-1.11.1-1.11.0-1.2-1.2-0.90.9-1.1
Retroperitoneal fat weight1.35.79.63.1-3.12.6-2.32.8-2.42.4-2.4-2.72.2-2.5-2.42.3-2.22.3-2.32.12.22.0-2.22.1-2.22.32.32.4-2.42.0
Reaction time number correct0.00.00.4-0.60.40.10.4-0.0-0.00.0-0.1-0.10.1-0.0-0.0-0.20.10.00.0-0.0-0.0-0.10.00.00.1-0.0-0.00.3-0.30.2
Reaction time mean minus median0.31.64.0-1.92.0-1.41.5-1.20.4-0.31.31.5-1.21.01.0-1.21.5-1.01.2-1.2-1.2-1.41.2-1.31.4-1.3-1.3-1.11.1-1.1
Reaction time mean minus median AUC0.10.61.5-1.11.2-0.80.9-0.7-0.10.20.91.0-0.80.60.6-0.71.0-0.60.7-0.7-0.7-1.00.8-0.80.9-0.8-0.8-0.40.4-0.7
Reaction time num false alarms0.10.10.2-0.20.30.20.10.2-0.50.5-0.3-0.20.4-0.4-0.40.4-0.20.4-0.40.40.40.4-0.40.4-0.30.40.40.4-0.40.4
Reaction time num false alarms AUC0.10.30.4-0.10.20.30.10.3-0.60.5-0.5-0.40.5-0.6-0.60.6-0.40.6-0.50.50.50.5-0.60.6-0.50.60.60.6-0.60.5
Reaction time trials correct on left0.00.00.4-0.60.40.10.4-0.0-0.00.0-0.1-0.10.1-0.0-0.0-0.20.10.00.0-0.0-0.0-0.10.00.00.1-0.0-0.00.3-0.30.2
Reaction time trials on left0.00.00.4-0.60.40.10.4-0.0-0.10.1-0.1-0.10.1-0.1-0.1-0.10.10.10.0-0.0-0.0-0.0-0.00.10.1-0.0-0.00.3-0.30.2
Reaction time mean0.41.04.1-2.02.0-1.11.0-1.1-0.10.31.01.1-0.80.70.6-0.81.3-0.60.8-0.8-0.9-1.10.8-0.81.0-0.9-0.9-0.80.8-0.8
Reaction time mean AUC0.41.04.4-2.02.1-1.01.0-1.0-0.30.51.01.1-0.80.60.6-0.71.3-0.60.8-0.7-0.8-1.10.7-0.81.0-0.8-0.8-0.70.7-0.7
Median of all reaction times0.50.73.6-1.91.9-0.90.8-1.0-0.20.30.80.9-0.60.60.5-0.61.1-0.50.7-0.6-0.7-0.80.6-0.60.9-0.7-0.7-0.70.7-0.7
Reaction time omissions0.20.31.4-0.30.40.2-0.10.4-1.11.2-0.4-0.20.6-0.6-0.60.5-0.10.6-0.50.60.40.3-0.40.5-0.30.30.30.6-0.60.7
Reaction time false alarm rate0.20.30.50.3-0.10.3-0.20.4-0.50.5-0.5-0.50.5-0.6-0.60.7-0.50.6-0.60.60.60.6-0.60.6-0.60.70.70.6-0.60.5
Reaction time premature initiation rate0.30.51.81.3-1.1-0.60.2-0.20.9-0.80.70.6-0.80.60.7-0.70.5-0.80.7-0.7-0.6-0.80.9-0.70.7-0.8-0.8-0.30.3-0.8
Reaction time premature initiations0.30.81.30.4-0.4-0.90.7-0.61.0-0.90.90.9-1.00.91.0-1.00.9-1.01.0-1.0-0.9-1.11.1-1.01.0-1.1-1.1-0.50.5-1.0
Std. dev. reaction times1.34.28.4-2.82.9-2.32.1-2.21.0-0.92.22.3-2.01.91.8-1.92.3-1.82.0-2.0-2.0-2.21.9-2.02.1-2.1-2.1-1.91.9-1.9
Reaction time trials completed0.00.00.4-0.60.40.10.4-0.0-0.10.1-0.1-0.10.1-0.1-0.1-0.10.10.10.0-0.0-0.0-0.0-0.00.10.1-0.0-0.00.3-0.30.2
Reaction time trials AUC0.00.00.5-0.70.50.10.3-0.1-0.10.1-0.1-0.10.10.0-0.0-0.20.20.00.1-0.0-0.0-0.10.00.00.1-0.1-0.10.2-0.20.1
Run reversals in cocaine runway, females0.10.11.21.1-0.80.00.2-0.00.3-0.30.30.5-0.30.20.2-0.40.1-0.30.2-0.2-0.4-0.30.4-0.20.2-0.3-0.30.2-0.2-0.2
Run reversals in cocaine runway, males1.92.14.10.8-0.81.3-1.91.4-2.02.0-1.5-1.41.6-1.5-1.61.4-1.31.6-1.51.51.41.5-1.51.4-1.41.41.41.0-1.01.6
Latency to leave start box in cocaine runway0.10.10.2-0.10.1-0.40.3-0.10.4-0.40.40.3-0.40.30.3-0.20.3-0.30.3-0.3-0.3-0.30.3-0.30.3-0.2-0.2-0.10.1-0.4
Latency to leave start box in cocaine runway, F2.22.83.8-1.31.3-1.91.6-1.61.4-1.31.81.7-1.71.71.7-1.71.9-1.71.8-1.8-1.8-1.81.8-1.81.8-1.7-1.7-1.21.2-1.9
Latency to leave start box in cocaine runway, M2.72.63.31.6-1.31.8-1.41.8-1.11.0-1.6-1.61.5-1.7-1.61.8-1.81.6-1.71.61.71.7-1.61.8-1.71.81.81.4-1.41.7
Std. dev. time between licks in bursts0.61.23.00.00.1-1.00.8-0.91.7-1.71.01.0-1.11.21.2-1.10.7-1.21.0-1.1-1.0-0.91.1-1.00.9-1.0-1.0-1.31.3-1.1
Total sessions with >9 infusions1.62.04.92.2-2.11.6-1.41.6-1.81.9-1.2-0.91.3-1.4-1.31.0-1.11.3-1.21.21.11.0-1.11.1-1.01.01.01.8-1.81.1
Short access day 1 total inactive lever presses0.10.20.4-0.60.60.00.5-0.2-0.20.30.30.4-0.40.20.2-0.40.5-0.20.4-0.4-0.5-0.60.4-0.40.5-0.5-0.50.2-0.2-0.4
Short access day 10 total inactive lever presses0.10.41.81.3-1.01.0-0.10.7-0.0-0.0-0.5-0.60.2-0.6-0.50.5-0.70.5-0.50.40.40.4-0.40.4-0.50.50.50.9-0.90.5
Short access day 1 total infusions0.71.53.21.3-1.41.4-1.01.3-1.71.8-1.1-0.91.2-1.3-1.31.0-0.91.2-1.11.11.00.9-1.01.1-0.91.01.01.5-1.51.0
Short access day 10 total infusions0.81.44.12.0-2.01.3-1.01.3-1.41.5-1.0-1.00.8-1.1-1.10.8-0.91.0-1.00.90.90.8-0.90.9-0.80.80.81.6-1.60.9
Short access total infusions0.81.13.11.2-1.31.1-1.11.1-1.61.8-0.9-0.81.0-1.0-1.00.8-0.71.0-0.90.90.90.8-0.90.9-0.70.70.71.4-1.40.8
Short access day 1 locomotion3.96.411.73.4-3.32.7-2.42.8-2.42.4-2.4-2.42.4-2.6-2.52.3-2.52.5-2.52.42.42.3-2.32.3-2.42.32.32.7-2.72.4
Short access day 10 total locomotion0.62.316.94.1-4.01.8-0.81.6-1.11.2-1.2-1.20.6-1.2-1.00.7-1.11.0-0.90.70.80.6-0.70.6-0.80.80.81.9-1.90.8
Short access total locomotion3.04.522.34.7-4.42.5-1.82.4-1.81.9-1.8-1.71.5-1.9-1.71.4-1.81.7-1.61.51.51.4-1.41.4-1.51.51.52.6-2.61.4
One hour access (0.3 mA shock)0.10.10.8-0.90.8-0.2-0.2-0.5-0.40.50.10.1-0.00.1-0.0-0.00.30.00.00.0-0.0-0.0-0.10.00.10.00.0-0.50.50.1
Compulsive drug intake0.60.94.1-2.01.9-0.90.7-1.20.5-0.40.81.0-0.70.80.7-0.71.0-0.70.8-0.7-0.7-0.80.7-0.70.8-0.6-0.6-1.51.5-0.5
One hour access (shock baseline)0.20.50.9-0.0-0.20.3-0.80.3-0.90.9-0.7-0.80.7-0.6-0.70.7-0.50.7-0.70.70.70.7-0.80.7-0.70.70.70.7-0.70.6
Social response proportion0.30.31.21.1-0.90.5-0.60.5-0.91.0-0.4-0.50.4-0.5-0.50.5-0.10.5-0.30.40.50.3-0.30.5-0.20.50.50.7-0.70.3
Social responses1.82.32.91.2-1.01.6-1.71.4-1.51.5-1.6-1.41.4-1.6-1.61.6-1.41.6-1.51.41.61.5-1.51.5-1.51.61.61.7-1.71.7
Social time0.20.30.9-0.70.9-0.30.9-0.4-0.10.20.50.5-0.50.30.3-0.30.8-0.40.5-0.6-0.4-0.70.6-0.50.7-0.3-0.3-0.10.1-0.5
Soleus weight2.06.06.81.5-1.72.4-2.32.5-2.52.5-2.5-2.42.6-2.5-2.62.5-2.42.6-2.52.62.62.5-2.62.6-2.52.52.52.4-2.42.6
Bone: stiffness0.30.50.70.3-0.40.7-0.70.7-0.80.8-0.7-0.70.8-0.7-0.70.7-0.60.7-0.70.90.70.8-0.70.8-0.70.60.60.4-0.40.6
Tibialis anterior weight2.89.614.62.4-2.53.1-3.23.0-3.83.8-3.1-3.03.2-3.2-3.33.1-2.83.3-3.13.13.13.0-3.23.1-3.03.03.02.8-2.83.1
Time to tail flick, vehicle, before self-admin0.30.40.8-0.50.40.4-0.00.4-0.80.7-0.8-0.70.9-0.6-0.60.6-0.50.7-0.70.60.60.7-0.80.7-0.60.80.8-0.10.10.7
Time to tail flick, vehicle, after self-admin0.20.40.8-0.1-0.30.5-0.70.2-0.1-0.0-0.8-0.60.9-0.5-0.50.7-0.90.6-0.70.80.70.9-0.80.6-0.90.70.7-0.20.20.8
Time to tail flick, test, before self-admin2.12.44.0-0.70.7-1.11.7-1.51.1-1.01.51.5-2.01.51.6-1.81.8-1.61.7-1.8-1.7-1.91.7-1.71.8-1.7-1.7-1.31.3-1.7
Time to tail flick, test, after self-admin1.41.52.81.3-1.71.3-1.50.9-1.21.2-1.4-1.31.2-1.2-1.21.4-1.21.2-1.21.11.11.2-1.21.1-1.21.31.30.8-0.81.2
Delta time to tail flick, vehicle, before/after SA0.10.21.1-0.3-0.0-0.3-0.0-0.51.0-1.10.20.3-0.30.40.4-0.2-0.0-0.40.2-0.2-0.2-0.10.2-0.30.0-0.3-0.3-0.30.3-0.3
Delta time to tail flick, test, before/after SA3.74.67.11.6-2.01.9-2.71.8-1.71.6-2.3-2.12.5-2.0-2.12.4-2.32.1-2.22.32.22.5-2.32.2-2.42.32.31.6-1.62.2
Tibia length3.39.210.7-2.82.8-3.03.0-3.02.8-2.73.13.1-3.03.13.1-3.13.1-3.13.1-3.1-3.1-3.03.1-3.13.1-3.1-3.1-3.33.3-3.1
Ambulatory time before self-admin0.51.78.42.9-2.41.5-0.51.6-0.40.3-1.2-1.00.9-1.2-1.01.0-1.41.0-1.00.91.00.9-0.80.9-1.11.01.01.8-1.80.9
Ambulatory time after self-admin0.91.411.13.3-2.81.3-1.01.5-0.60.7-0.8-0.80.6-1.0-0.80.9-1.00.8-0.80.70.80.6-0.50.7-0.70.90.91.3-1.30.8
Bone: tissue strength3.53.64.01.5-1.61.9-1.91.9-1.91.8-1.9-1.92.0-2.0-2.02.0-1.92.0-2.02.02.01.9-2.02.0-1.92.02.01.9-1.92.0
Total heroin consumption0.50.61.5-1.21.1-0.70.4-0.80.9-0.90.60.8-0.40.80.8-0.80.6-0.80.7-0.5-0.5-0.60.8-0.70.7-0.8-0.8-0.60.6-0.7
Bone: trabecular number0.10.20.40.3-0.40.4-0.60.3-0.30.3-0.4-0.30.5-0.3-0.40.4-0.50.4-0.50.50.50.6-0.50.4-0.50.30.30.1-0.10.5
Bone: trabecular spacing0.00.10.30.6-0.40.2-0.10.3-0.00.0-0.2-0.30.1-0.2-0.20.1-0.20.2-0.20.10.10.1-0.10.1-0.20.30.30.6-0.60.2
Bone: trabecular thickness0.00.10.3-0.60.5-0.2-0.1-0.2-0.40.50.20.2-0.00.10.0-0.00.3-0.00.1-0.0-0.1-0.10.1-0.10.2-0.2-0.20.1-0.1-0.1
Bone: trabecular tissue density0.61.01.40.6-0.81.0-1.20.9-1.11.2-1.0-0.90.9-1.0-1.01.1-0.91.1-1.01.11.11.0-1.01.1-1.01.01.01.0-1.01.0
Water consumed over 24 hours0.40.71.10.4-0.40.7-1.00.8-0.90.8-0.8-0.81.0-0.8-0.90.9-0.90.9-0.91.00.91.1-1.00.9-1.00.90.90.7-0.71.0
Number of responses in last shaping day0.60.71.20.2-0.20.9-0.40.7-0.50.4-0.9-0.61.0-0.9-0.90.9-0.90.9-0.91.00.91.0-1.01.0-1.00.80.80.9-0.91.1