Hub : Genes

Ssh3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	alternative polyA	XM_039085534.1	0.18	0.13	2.9e-03	0.1	0.01	0.09	0	2.0e-03	1.5e-01	3.7e-03	2.4e-01
2	NAcc	intron excision ratio	chr1_201561649_201561831	0.02	0.02	5.9e-03	0.02	0.02	0.01	0.02	2.4e-03	3.6e-03	5.9e-03	2.9e-03
3	LHb	alternative polyA	XM_039085520.1	0.17	0.12	5.0e-03	0.02	0	0.07	-0.01	1.1e-01	2.7e-01	8.2e-03	5.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.6	2.6	3.4	1.5	1.5	-1.8
Area under the delay curve	1.4	1.5	1.9	1.0	1.4	-1.2
BMI with tail	0.3	0.8	1.8	0.2	0.8	-1.3
BMI without tail	0.1	0.2	0.7	0.1	0.2	-0.8
Body weight	0.8	3.4	5.2	-2.3	-2.0	1.1
Weight adjusted by age	1.0	1.1	1.9	-0.9	-1.4	0.8
Bone surface	0.3	0.5	1.0	0.6	0.4	-1.0
Bone volume	0.8	1.4	1.8	1.1	1.1	-1.3
Breakpoint value in progressive ratio session	0.6	0.7	1.0	-0.8	-1.0	0.7
Number of licking bursts	0.0	0.0	0.0	0.2	-0.0	-0.1
Context. condit. distance diff. score	0.7	0.8	0.9	0.9	0.9	-0.9
Locomotion velocity, session 1	0.1	0.1	0.4	-0.1	-0.6	-0.0
Locomotion distance, session 1	0.5	0.7	1.3	0.6	0.6	-1.1
Locomotion velocity, session 2	0.9	1.1	1.6	-1.3	-1.0	0.9
Locomotion distance, session 2	0.0	0.0	0.1	-0.2	-0.0	-0.3
Locomotion velocity, session 3	1.0	1.2	2.2	1.0	0.6	-1.5
Locomotion distance, session 3	0.1	0.1	0.1	0.1	-0.0	-0.4
Stereotopy head waving bouts, day 3	1.9	2.2	3.0	1.7	1.0	-1.7
Stereotopy head waving duration, day 3	1.8	2.2	2.7	1.6	1.3	-1.5
Locomotion velocity, session 7	1.0	1.1	1.5	0.9	1.0	-1.2
Locomotion distance, session 7	0.0	0.0	0.0	-0.1	-0.1	-0.2
Stereotopy head waving bouts, day 7	1.8	2.0	2.3	1.5	1.2	-1.5
Stereotopy head waving duration, day 7	0.5	0.6	1.1	0.7	0.6	-1.0
Locomotion velocity, session 8	0.7	0.8	1.4	-0.9	-1.2	0.4
Locomotion distance, session 8	0.4	0.5	0.7	0.6	0.7	-0.9
Degree of sensitization distance	0.1	0.1	0.2	0.3	0.3	-0.4
Degree of sensitization stereotypy	0.2	0.2	0.4	0.4	0.3	-0.6
Conditioned locomotion	4.3	5.0	5.9	-2.4	-2.0	2.3
Cocaine response after cond. corrected	0.2	0.2	0.3	0.4	0.3	-0.6
Cocaine response after cond. not corrected	0.6	0.7	1.0	0.7	0.7	-1.0
Cocaine response before conditioning	0.1	0.1	0.1	0.2	0.3	-0.3
Saline control response	0.8	1.1	1.6	-1.3	-1.0	0.7
Bone: connectivity density	0.6	0.9	1.8	0.7	0.7	-1.3
Bone: cortical apparent density	0.5	0.7	1.0	-1.0	-0.8	0.6
Bone: cortical area	1.0	1.5	1.6	-1.2	-1.2	1.3
Bone: cortical porosity	0.1	0.2	0.4	0.2	0.6	-0.2
Bone: cortical porosity	0.1	0.1	0.1	-0.3	0.1	0.2
Bone: cortical thickness	6.3	10.4	11.1	-3.3	-3.3	3.0
Bone: cortical thickness	2.9	3.4	5.0	-1.8	-2.2	1.4
Bone: cortical tissue density	0.7	0.9	1.2	-1.1	-0.9	0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.4	0.5	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.4	0.6	-0.6
Condit. Reinf. active responses	0.1	0.1	0.1	0.1	0.4	-0.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	0.2	0.2
Incentive salience index mean	0.1	0.1	0.1	0.1	0.3	-0.4
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.4	-0.2	0.4
Condit. Reinf. active minus inactive responses	2.1	2.6	2.8	1.6	1.5	-1.7
Condit. Reinf. active-inactive response ratio	2.4	2.5	2.8	1.7	1.6	-1.4
Condit. Reinf. active responses	1.7	2.4	2.8	1.5	1.5	-1.7
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.2	0.5	-0.7
Condit. Reinf. lever presses	0.1	0.1	0.1	0.2	-0.1	-0.4
Condit. Reinf. lever reinforcers received	1.3	1.9	2.5	1.3	1.2	-1.6
Conditioned reinforcement - actives	0.1	0.1	0.1	-0.1	0.2	0.4
Conditioned reinforcement - inactives	2.8	3.1	4.2	2.1	1.9	-1.2
Conditioned locomotion	1.1	1.4	2.0	1.4	1.4	-0.4
Patch foraging indifference point 0 sec	0.4	0.6	0.8	0.8	0.9	-0.5
Patch foraging indifference point AUC	2.1	2.5	2.9	-1.5	-1.7	1.5
Delay disc. indifference point, 0s delay	1.6	1.8	2.7	1.3	0.9	-1.6
Delay disc. indifference point, 16s delay	2.0	2.1	3.8	1.3	1.9	-0.9
Delay disc. indifference point, 2s delay	0.9	1.0	1.3	1.2	0.8	-1.0
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.6	-0.0	0.6
Delay disc. indifference point, 4s delay	0.5	0.5	0.7	0.5	0.8	-0.8
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	0.4	0.7	-0.8
Indifference point function ln k	2.0	2.7	3.2	1.8	1.8	-1.4
Indifference point function log k	2.0	2.7	3.2	1.8	1.8	-1.4
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.2	0.2	0.1
Patch foraging total patch changes 12 sec	1.2	1.5	1.8	-1.2	-1.4	1.0
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.1	-0.2	0.2
Patch foraging total patch changes 24 sec	1.3	1.6	2.0	-1.2	-1.4	1.1
Patch foraging total patch changes 6 sec	0.0	0.1	0.1	-0.0	-0.3	-0.2
Patch foraging time to switch 0 sec	0.4	0.6	1.3	0.6	0.5	-1.1
Patch foraging water rate 0 sec	0.2	0.4	1.0	-0.1	0.2	1.0
Patch foraging water rate 12 sec	0.2	0.2	0.5	0.2	0.4	0.7
Patch foraging water rate 18 sec	0.2	0.2	0.4	0.5	0.6	-0.3
Patch foraging water rate 24 sec	0.2	0.2	0.6	-0.2	0.1	0.8
Patch foraging water rate 6 sec	0.2	0.3	0.7	-0.4	-0.3	0.8
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.1	0.8	0.9	-1.0
Distance traveled before self-admin	0.0	0.0	0.0	0.1	-0.2	0.0
Distance traveled after self-admin	0.0	0.0	0.0	-0.1	-0.0	-0.1
Extensor digitorum longus weight	3.7	14.5	17.7	-4.2	-3.9	3.2
Bone: elastic displacement	1.7	1.9	2.6	-1.3	-1.2	1.6
Bone: elastic work	3.1	4.1	4.9	-2.0	-2.2	1.8
Bone: endosteal estimation	2.5	5.5	6.1	2.5	2.5	-2.1
Bone: endosteal perimeter	5.0	10.5	11.7	3.4	3.3	-2.9
Epididymis fat weight	1.7	3.9	4.9	2.2	2.2	-1.4
Delta time in closed arm before/after self-admin	1.4	1.3	1.7	-1.3	-1.1	1.0
Delta time in open arm before/after self-admin	0.2	0.2	0.4	0.6	0.0	-0.3
Diff in mean of infusions in LGA sessions	0.5	0.5	0.7	-0.6	-0.7	0.8
Delay discount exponential model param	1.0	1.1	1.5	-0.8	-1.2	1.0
Extinction: sum of active levers before priming	0.5	0.5	0.9	-1.0	-0.7	0.3
Active lever presses in extinction session 6	3.0	2.9	2.9	-1.7	-1.7	1.7
Bone: final force	0.4	0.6	1.1	-0.7	-1.1	0.5
Bone: final moment	0.3	0.5	0.9	-0.7	-1.0	0.4
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.0	-0.0	0.3
Glucose	3.4	5.0	5.6	2.2	2.4	-2.2
Heart weight	1.1	1.6	1.9	1.4	1.3	-1.1
Delay discount hyperbolic model param	0.9	1.0	1.2	-0.8	-1.1	1.1
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.4	-0.3	0.3
Intermittent access intake escalation	0.2	0.2	0.5	0.7	-0.0	-0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	0.1	-0.4	0.2
Intermitt. access day 1 inactive lever presses	1.3	1.4	1.8	1.3	1.2	-1.0
Intermitt. access day 15 inactive lever presses	1.8	2.0	2.9	1.7	1.2	-1.3
Intermitt. access escalation Index	1.2	1.0	2.4	0.8	1.6	-0.3
Intermittent access day 1 total infusions	9.6	11.1	12.6	3.4	3.5	-3.1
Intermittent access day 15 total infusions	6.5	7.3	9.6	3.1	2.8	-2.2
Intermittent access terminal intake (last 3 days)	6.3	6.8	8.8	3.0	2.6	-2.2
Intermittent access total infusions	6.2	6.8	8.4	2.7	2.9	-2.2
Intermittent access day 1 locomotion	6.5	6.8	8.2	2.5	2.9	-2.4
Intermittent access day 15 total locomotion	3.9	4.2	5.1	2.2	2.3	-1.6
Intermittent access total locomotion	9.1	10.3	12.7	3.3	3.6	-2.7
Intermittent access standard deviation	0.1	0.1	0.3	0.6	0.2	-0.2
Left kidney weight	0.0	0.1	0.2	0.4	0.2	0.2
Right kidney weight	0.1	0.3	0.8	-0.2	-0.4	0.9
Cocaine induced anxiety	0.0	0.0	0.1	-0.1	-0.3	0.1
Post-drug Anxiety	1.6	1.8	2.1	-1.4	-1.4	1.2
Baseline Anxiety	2.2	2.3	2.8	-1.7	-1.6	1.3
Tail length	1.7	5.2	7.0	-2.2	-2.6	1.9
Length with tail	2.6	9.3	10.8	-3.2	-3.3	2.6
Length without tail	1.6	3.5	4.4	-2.1	-1.9	1.6
Times rat made contact with spout	0.1	0.1	0.2	0.1	0.0	-0.4
Lifetime Intake	5.4	6.1	7.6	2.5	2.7	-2.1
Liver weight, left	0.1	0.1	0.2	0.4	-0.3	-0.1
Liver weight, right	0.1	0.1	0.2	-0.3	-0.3	0.5
Locomotor activity	0.0	0.0	0.1	0.3	0.0	0.1
Locomotor testing distance	0.0	0.1	0.2	0.5	0.1	-0.1
Locomotor testing rearing	1.0	1.5	2.2	1.5	0.9	-1.2
Locomotion in novel chamber	3.7	4.6	6.7	2.6	2.0	-1.8
Locomotion in novel chamber post-restriction	1.0	1.2	1.8	1.4	1.2	-0.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	0.3	-0.3	-0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.1	0.5	-0.2
Time >=10cm from walls, locomotor time 1	4.9	5.0	6.0	2.2	2.4	-2.1
Bouts of movement, locomotor time 1	1.4	1.6	2.1	-1.5	-0.7	1.4
Total resting periods, locomotor time 1	0.9	1.0	1.5	-1.2	-0.4	1.2
Rest time, locomotor task time 1	0.1	0.2	0.3	0.0	0.6	0.4
Distance moved, locomotor task time 1	0.7	0.7	1.1	0.9	0.6	-1.0
Vertical activity count, locomotor time 1	1.2	1.3	2.0	1.4	0.6	-1.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.2	0.6	0.2
Bouts of movement, locomotor time 2	0.3	0.4	0.6	-0.8	-0.3	0.6
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.4	-0.0	0.3
Rest time, locomotor task time 2	2.0	2.3	3.3	1.8	1.1	-1.5
Distance moved, locomotor task time 2	0.9	1.0	1.4	-1.2	-0.7	1.1
Vertical activity count, locomotor time 2	2.1	2.3	2.7	-1.5	-1.3	1.7
Light reinforcement 1	0.0	0.1	0.1	0.3	0.2	0.2
Light reinforcement 2	0.4	0.5	0.8	0.8	0.9	-0.0
Bone: marrow area	2.6	5.6	6.2	2.5	2.5	-2.1
Bone: maximum diameter	0.0	0.0	0.1	0.1	0.0	0.2
Bone: maximum force	0.2	0.3	0.6	0.4	-0.1	-0.8
Bone: maximum moment	0.1	0.2	0.5	0.3	-0.0	-0.7
Mean time between licks in bursts	0.4	0.6	1.0	-1.0	-0.7	0.5
Mean num. licks in bursts	0.1	0.1	0.2	0.2	0.3	-0.4
Cd content in liver	0.2	0.2	0.3	0.6	0.5	-0.1
Co content in liver	0.5	0.5	0.6	-0.7	-0.7	0.8
Cu content in liver	0.1	0.2	0.2	-0.5	-0.2	0.5
Fe content in liver	0.1	0.1	0.2	-0.2	-0.5	0.2
K content in liver	0.2	0.2	0.5	0.2	0.0	-0.7
Mg content in liver	2.8	2.8	3.5	1.6	1.5	-1.9
Mn content in liver	0.4	0.5	0.6	-0.7	-0.8	0.5
Na content in liver	0.7	0.7	0.9	-0.7	-0.9	0.9
Rb content in liver	3.6	4.4	5.4	2.3	1.7	-2.2
Se content in liver	0.9	1.1	1.2	1.1	1.0	-1.0
Sr content in liver	3.2	2.9	3.2	-1.8	-1.7	1.7
Zn content in liver	0.4	0.4	0.6	-0.8	-0.4	0.6
Bone: minimum diameter	3.0	5.6	6.1	2.3	2.5	-2.3
Time in familiar zone, hab. session 1	1.0	1.0	1.3	1.0	1.2	-0.8
Time in novel zone, hab. session 1	0.3	0.3	0.6	-0.5	-0.7	0.2
Total zone transitions, hab. session 1	0.0	0.1	0.1	-0.2	-0.4	0.1
Total locomotion distance, hab. session 1	0.5	0.7	1.1	1.0	0.7	-0.7
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.6	0.3	-0.3
Time in familiar zone, hab. session 2	1.2	1.2	1.7	-1.3	-0.9	1.1
Time in novel zone, hab. session 2	1.2	1.2	1.5	1.1	0.8	-1.2
Total zone transitions, hab. session 2	1.2	1.6	2.6	1.0	1.1	-1.6
Total locomotion distance, hab. session 2	1.3	1.8	2.1	1.3	1.2	-1.4
Locomotion velocity, hab. session 2	1.7	2.2	2.4	1.5	1.4	-1.5
Novel to familiar place preference ratio	0.1	0.1	0.2	0.3	0.4	-0.4
Novelty place preference	0.3	0.4	0.4	0.5	0.6	-0.7
Time in novel zone, NPP test	0.4	0.4	0.5	0.5	0.6	-0.7
Total zone transitions, NPP test	0.1	0.1	0.2	0.1	-0.2	-0.5
Total locomotion distance, NPP test	0.3	0.5	0.7	0.8	0.4	-0.8
Locomotion velocity, NPP test	0.2	0.3	0.5	0.7	0.3	-0.6
Intraocular pressure	0.2	0.3	0.7	-0.5	-0.1	0.8
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.2	-0.1	-0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.5	-0.2	0.1
Parametrial fat weight	2.0	3.9	4.1	2.0	2.0	-1.9
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	0.2	0.1
Pavlov. Cond. magazine entry latency	1.0	1.2	1.5	1.1	1.0	-1.2
Pavlov. Cond. change in total contacts	0.7	0.8	0.9	1.0	0.8	-0.9
Pavlov. Cond. index score	0.0	0.0	0.0	0.2	0.1	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.1	0.3	0.1	-0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.0	-0.1	-0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.1	0.1	-0.2
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	-0.3	-0.0	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	0.0	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.0	0.1	-0.1	-0.1
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	0.2	-0.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	-0.2	-0.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.5	0.3	-0.5
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	-0.1	-0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	0.0	-0.1	-0.2
Pavlov. Cond. lever contacts	0.1	0.2	0.2	-0.3	-0.4	0.5
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.4	0.5	0.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	0.7	0.6	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	-0.3	-0.1
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.2	-0.3	0.1
Time in closed arm before self-admin	0.4	0.4	0.5	0.7	0.7	-0.5
Time in closed arm after self-admin	0.2	0.2	0.3	-0.4	-0.1	0.5
Time in open arm before self-admin	0.2	0.2	0.5	-0.7	-0.1	0.4
Time in open arm after self-admin	0.1	0.1	0.2	-0.4	-0.3	0.2
Bone: periosteal estimation	0.2	0.3	0.5	0.7	0.6	-0.4
Bone: periosteal perimeter	0.5	0.8	1.0	1.0	0.8	-0.8
Bone: post-yield work	8.1	11.0	11.7	3.2	3.3	-3.4
Progressive ratio test 1 active lever presses	1.3	1.3	2.7	1.0	1.6	-0.6
Progressive ratio test 1 breakpoint	0.9	1.0	2.0	0.9	1.4	-0.4
Progressive ratio test 1 inactive lever presses	0.9	0.9	1.6	0.8	1.3	-0.7
Progressive ratio test 2 active lever presses	2.6	2.8	4.6	1.6	2.2	-1.1
Progressive ratio test 2 breakpoint	1.9	2.1	3.9	1.4	2.0	-0.7
Progressive ratio test 2 inactive lever presses	7.1	8.2	10.8	3.0	3.3	-2.2
Incentive Sensitization - Responses	0.4	0.4	0.9	0.5	0.9	-0.5
Incentive Sensitization - Breakpoint	0.5	0.5	0.9	0.6	0.9	-0.5
Sum of active levers in priming session hrs 5-6	3.4	3.3	4.1	-1.9	-1.5	2.0
Progressive ratio	0.9	1.0	1.9	0.9	0.6	-1.4
Food seeking constrained by brief footshock	0.2	0.2	0.6	-0.2	-0.8	0.0
Seeking ratio, punishment vs. effort	0.5	0.6	0.9	-0.6	-0.6	1.0
Retroperitoneal fat weight	2.7	9.0	11.3	3.3	3.4	-2.3
Reaction time number correct	1.2	1.7	1.9	-1.4	-1.1	1.4
Reaction time mean minus median	0.2	0.3	0.6	-0.5	-0.8	0.1
Reaction time mean minus median AUC	0.9	1.2	2.0	-1.1	-1.4	0.7
Reaction time num false alarms	0.7	1.0	1.3	-1.1	-0.9	1.0
Reaction time num false alarms AUC	1.2	1.7	2.1	-1.5	-1.3	1.1
Reaction time trials correct on left	1.2	1.7	1.9	-1.4	-1.1	1.4
Reaction time trials on left	1.5	2.1	2.4	-1.5	-1.3	1.5
Reaction time mean	0.2	0.3	0.5	0.7	0.3	-0.7
Reaction time mean AUC	0.4	0.5	0.7	0.8	0.4	-0.8
Median of all reaction times	0.6	0.8	1.1	1.0	0.6	-1.0
Reaction time omissions	1.1	1.5	2.0	-1.4	-1.3	0.9
Reaction time false alarm rate	0.2	0.3	0.5	-0.7	-0.6	0.4
Reaction time premature initiation rate	1.6	2.1	3.0	-1.6	-1.7	0.9
Reaction time premature initiations	3.8	5.3	6.3	-2.5	-2.5	1.9
Std. dev. reaction times	0.0	0.0	0.1	-0.1	-0.3	-0.2
Reaction time trials completed	1.5	2.1	2.4	-1.5	-1.3	1.5
Reaction time trials AUC	1.0	1.5	1.8	-1.3	-1.1	1.3
Run reversals in cocaine runway, females	0.3	0.3	0.7	0.3	0.0	-0.8
Run reversals in cocaine runway, males	1.7	1.6	2.5	-1.1	-1.6	1.1
Latency to leave start box in cocaine runway	1.2	1.2	1.4	1.1	1.1	-1.2
Latency to leave start box in cocaine runway, F	0.6	0.6	0.9	0.7	0.7	-1.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.3	0.3	-0.1
Std. dev. time between licks in bursts	1.7	2.0	2.6	-1.6	-1.3	1.4
Total sessions with >9 infusions	1.5	1.6	2.3	1.2	1.5	-1.1
Short access day 1 total inactive lever presses	2.4	2.7	3.4	1.8	1.9	-1.3
Short access day 10 total inactive lever presses	1.0	1.1	1.6	1.3	0.8	-1.0
Short access day 1 total infusions	4.6	4.9	6.4	2.2	2.5	-1.9
Short access day 10 total infusions	5.7	6.4	7.4	2.4	2.7	-2.4
Short access total infusions	2.9	3.3	4.0	1.7	2.0	-1.7
Short access day 1 locomotion	3.8	4.1	5.7	1.9	2.4	-1.7
Short access day 10 total locomotion	2.5	2.8	4.1	1.5	2.0	-1.4
Short access total locomotion	2.5	2.6	4.0	1.4	2.0	-1.4
One hour access (0.3 mA shock)	5.1	5.9	7.3	2.7	2.6	-1.9
Compulsive drug intake	3.7	3.7	4.6	-2.2	-2.0	1.5
One hour access (shock baseline)	5.4	6.3	8.0	2.8	2.8	-1.7
Social response proportion	0.1	0.1	0.1	-0.2	0.3	-0.4
Social responses	0.5	0.6	1.1	-1.1	-0.4	0.7
Social time	0.2	0.3	0.4	-0.7	-0.6	0.3
Soleus weight	0.6	1.9	2.8	1.6	1.7	-0.6
Bone: stiffness	0.4	0.6	1.1	0.7	0.4	-1.0
Tibialis anterior weight	8.7	29.8	33.0	-5.7	-5.5	5.1
Time to tail flick, vehicle, before self-admin	1.1	1.1	2.0	1.4	0.1	-1.2
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.9	-0.9	-0.6	0.2
Time to tail flick, test, before self-admin	2.1	2.1	2.7	1.4	1.2	-1.6
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.4	-0.1	0.3
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.8	-1.3	-0.2	0.7
Delta time to tail flick, test, before/after SA	4.8	4.4	5.1	-2.1	-1.8	2.3
Tibia length	0.9	2.6	3.7	-1.5	-1.4	1.9
Ambulatory time before self-admin	0.0	0.0	0.1	0.3	0.1	-0.2
Ambulatory time after self-admin	1.3	1.4	1.4	1.2	1.2	-1.2
Bone: tissue strength	0.3	0.3	0.4	0.6	0.6	-0.4
Total heroin consumption	1.8	2.2	2.7	-1.7	-1.5	1.2
Bone: trabecular number	1.1	1.8	2.3	1.2	1.2	-1.5
Bone: trabecular spacing	0.2	0.3	0.5	-0.5	-0.4	0.7
Bone: trabecular thickness	2.5	3.0	3.2	1.6	1.8	-1.8
Bone: trabecular tissue density	0.5	0.7	1.0	1.0	1.0	-0.1
Water consumed over 24 hours	0.1	0.1	0.2	-0.2	-0.4	-0.1
Number of responses in last shaping day	0.1	0.1	0.2	0.3	0.4	-0.1