Hub : Genes

Srsf5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb alternative TSS XM_039111859.2 0.22 0.14 9.4e-03 0.02 0.06 0 0.05 1.0e-01 1.8e-02 3.1e-01 2.5e-02
2 Adipose mRNA stability Srsf5 0.03 0.02 5.1e-03 0 0 0 -0 3.4e-01 2.4e-01 1.6e-01 4.6e-01
3 IL isoform ratio XR_010052053.1 0.74 0.12 3.5e-04 0.08 0.18 0.22 0.22 7.1e-03 4.7e-05 5.4e-06 4.2e-06
4 Liver intron excision ratio chr6_106338816_106340047 0.07 0.04 2.4e-05 0.05 0.04 0.03 0.04 3.7e-06 2.6e-05 9.9e-05 2.0e-05
5 Liver alternative TSS NM_001195505.1 0.04 0.02 1.4e-03 0.01 0.01 0.01 0 4.2e-02 8.4e-03 1.8e-02 8.9e-02
6 Liver alternative polyA XM_039111859.2 0.03 0.02 5.8e-03 0.01 0.01 0 0.01 8.2e-03 4.4e-02 2.6e-01 3.3e-02
7 Liver alternative polyA XM_063261591.1 0.03 0.02 2.9e-03 0.01 0.01 0 0.01 6.9e-03 2.0e-02 1.4e-01 2.0e-02
8 Liver alternative TSS XM_039111860.2 0.04 0.02 3.6e-03 0 0.01 0.01 0 7.2e-02 1.7e-02 5.2e-02 1.0e-01
9 Liver isoform ratio NM_001195506.1 0.06 0.04 1.1e-04 0.03 0.02 0.02 0.02 1.7e-04 2.4e-03 3.5e-03 3.6e-03
10 Liver gene expression Srsf5 0.04 0.02 4.3e-04 0.02 0.02 0.02 0.02 1.6e-03 3.3e-03 3.4e-03 5.3e-03
11 NAcc gene expression Srsf5 0.05 0.04 9.4e-03 0 0 -0 -0 1.2e-01 9.2e-02 5.2e-01 5.0e-01
12 Liver isoform ratio NM_001195505.1 0.13 0.07 2.2e-04 0.05 0.03 0.03 0.03 5.1e-06 6.2e-04 6.2e-04 1.9e-04
13 Liver intron excision ratio chr6_106338816_106339079 0.05 0.03 4.6e-04 0.01 0.03 0.03 0.02 2.4e-02 4.2e-04 1.9e-04 3.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.61.03.71.01.9-1.21.40.30.3-0.3-0.50.4-1.0-1.7-0.8-0.2
Area under the delay curve0.30.30.80.70.6-0.40.60.30.2-0.2-0.40.5-0.1-0.5-0.9-0.9
BMI with tail1.34.59.3-1.81.33.12.82.81.5-1.5-2.71.6-2.3-0.4-2.8-0.3
BMI without tail1.95.610.91.93.3-1.13.22.12.4-2.4-2.42.5-1.9-1.6-2.9-2.2
Body weight1.46.118.63.34.3-1.82.81.62.0-2.0-1.92.3-3.2-0.8-2.2-1.9
Weight adjusted by age1.11.76.11.42.5-0.11.90.7-0.00.0-0.70.2-0.9-2.3-1.7-0.5
Bone surface0.71.26.81.01.9-0.81.3-0.3-0.40.40.2-0.4-0.3-2.6-0.70.8
Bone volume0.71.35.91.61.8-1.90.8-0.7-0.30.30.4-0.2-0.1-2.4-0.30.4
Breakpoint value in progressive ratio session0.81.03.70.11.90.41.80.5-0.30.3-0.5-0.7-1.4-1.6-0.50.0
Number of licking bursts0.61.03.6-1.7-1.71.9-0.50.50.2-0.2-0.30.11.30.5-0.7-0.2
Context. condit. distance diff. score0.50.62.01.30.8-1.40.40.20.7-0.7-0.30.9-0.60.8-0.0-0.8
Locomotion velocity, session 10.50.51.2-0.7-0.30.5-0.2-0.5-1.11.10.6-1.00.1-0.11.00.9
Locomotion distance, session 10.50.62.1-1.5-0.61.10.81.20.3-0.3-1.10.30.00.3-0.5-0.4
Locomotion velocity, session 20.20.20.6-0.5-0.4-0.3-0.8-0.2-0.40.40.00.0-0.20.70.3-0.5
Locomotion distance, session 20.50.74.0-2.0-1.31.10.20.90.0-0.0-0.80.00.40.60.1-0.2
Locomotion velocity, session 32.02.36.91.2-1.3-2.6-2.3-1.9-0.90.91.6-0.61.50.61.8-0.2
Locomotion distance, session 30.80.82.50.7-0.5-1.2-1.1-1.2-0.70.71.1-0.51.6-1.00.60.1
Stereotopy head waving bouts, day 30.40.52.01.40.8-1.1-0.5-0.7-0.20.20.50.10.3-1.0-0.5-0.2
Stereotopy head waving duration, day 30.50.71.81.10.3-1.3-1.1-1.3-0.60.61.0-0.30.4-0.60.50.2
Locomotion velocity, session 71.92.05.0-0.5-1.7-0.3-2.2-1.7-1.41.41.7-1.01.80.11.71.0
Locomotion distance, session 70.40.51.1-0.8-0.90.6-0.20.80.9-0.9-0.71.10.30.7-0.3-0.6
Stereotopy head waving bouts, day 71.01.25.42.31.5-2.30.3-0.50.1-0.10.2-0.0-0.5-1.00.0-0.6
Stereotopy head waving duration, day 71.31.67.42.61.9-2.70.4-0.50.4-0.40.10.3-1.0-0.90.1-0.8
Locomotion velocity, session 80.20.21.0-0.6-0.20.10.30.40.0-0.0-0.40.1-0.81.00.70.0
Locomotion distance, session 80.40.61.3-0.2-0.2-0.40.61.11.0-1.0-1.11.1-0.21.0-0.3-0.8
Degree of sensitization distance0.91.02.1-0.60.00.80.81.31.1-1.1-1.21.2-1.11.4-0.5-0.7
Degree of sensitization stereotypy0.91.04.72.21.4-2.10.4-0.30.3-0.30.1-0.0-0.8-0.50.2-0.6
Conditioned locomotion2.52.94.9-0.5-2.0-0.6-2.2-2.0-2.02.02.0-1.91.90.41.91.1
Cocaine response after cond. corrected2.83.35.8-1.2-2.40.1-2.1-1.9-2.22.22.0-2.02.4-0.31.61.5
Cocaine response after cond. not corrected2.22.64.5-1.4-2.10.1-1.9-1.6-1.81.81.7-1.82.1-0.41.61.3
Cocaine response before conditioning0.40.51.1-0.31.00.20.80.70.9-0.9-0.70.7-0.8-0.7-0.3-0.3
Saline control response0.10.10.4-0.4-0.2-0.20.10.40.4-0.4-0.50.5-0.30.2-0.1-0.6
Bone: connectivity density0.71.12.70.51.6-0.01.61.00.7-0.7-1.10.8-0.9-1.3-1.5-0.3
Bone: cortical apparent density0.20.31.20.50.2-1.1-0.20.00.0-0.0-0.20.6-0.20.6-0.2-0.9
Bone: cortical area0.50.82.31.40.1-1.5-1.1-1.3-0.60.61.2-0.50.6-0.60.60.2
Bone: cortical porosity0.80.92.20.91.10.61.11.01.0-1.0-1.01.0-1.50.3-0.8-0.6
Bone: cortical porosity0.60.71.31.11.10.21.00.70.8-0.8-0.70.9-1.10.1-0.7-0.4
Bone: cortical thickness0.30.51.20.4-0.8-0.7-0.70.20.8-0.8-0.21.00.11.1-0.1-0.8
Bone: cortical thickness1.31.57.4-1.8-2.71.4-1.00.4-0.20.2-0.1-0.40.82.10.90.1
Bone: cortical tissue density0.10.21.00.40.2-1.0-0.20.0-0.00.0-0.20.5-0.20.6-0.2-0.8
Condit. Reinf. active minus inactive responses1.31.53.01.71.4-1.31.71.10.8-0.8-1.10.8-1.60.9-0.4-1.4
Condit. Reinf. active-inactive response ratio1.11.13.41.81.3-1.81.30.60.6-0.6-0.70.7-1.10.5-0.2-1.0
Condit. Reinf. active responses1.61.93.51.31.1-0.41.91.61.3-1.3-1.61.2-1.91.7-0.6-1.3
Condit. Reinf. inactive responses1.92.34.7-0.90.22.21.62.11.6-1.6-1.91.3-1.61.6-1.2-0.6
Incentive salience index mean0.70.92.21.21.2-0.71.50.90.6-0.6-0.90.5-1.50.9-0.0-0.6
Condit. Reinf. lever presses0.20.30.9-0.10.70.61.00.50.2-0.2-0.40.1-0.90.40.40.7
Condit. Reinf. active minus inactive responses2.63.47.5-0.50.71.42.32.71.8-1.8-2.62.0-2.11.4-1.7-1.4
Condit. Reinf. active-inactive response ratio1.92.23.80.41.00.31.71.91.7-1.7-1.91.9-1.60.7-1.7-1.4
Condit. Reinf. active responses0.91.23.1-0.00.80.51.51.61.0-1.0-1.51.2-1.80.8-0.7-0.8
Condit. Reinf. inactive responses0.50.62.1-0.6-0.40.3-0.9-0.6-0.80.80.7-0.8-0.10.41.41.1
Condit. Reinf. lever presses0.20.31.40.41.20.10.8-0.0-0.20.2-0.0-0.4-0.9-0.9-0.00.2
Condit. Reinf. lever reinforcers received1.11.64.6-0.11.00.71.81.81.0-1.0-1.71.1-2.10.9-0.8-0.9
Conditioned reinforcement - actives0.30.52.0-0.5-0.30.40.10.80.4-0.4-0.80.6-1.21.40.2-1.1
Conditioned reinforcement - inactives0.60.92.1-1.4-1.41.3-0.30.2-1.31.30.1-1.0-0.21.10.80.4
Conditioned locomotion0.50.62.2-1.3-1.20.6-0.80.4-0.20.2-0.30.1-0.41.50.6-0.7
Patch foraging indifference point 0 sec0.40.82.50.91.6-0.00.80.50.5-0.5-0.61.0-1.1-1.0-1.3-0.9
Patch foraging indifference point AUC0.40.51.30.70.1-1.2-0.8-1.0-0.70.70.9-0.7-0.00.21.1-0.1
Delay disc. indifference point, 0s delay2.12.34.4-0.41.01.21.92.11.6-1.6-2.11.7-1.60.4-2.0-1.0
Delay disc. indifference point, 16s delay0.91.02.41.3-0.1-1.5-0.7-1.2-1.11.11.2-0.91.0-0.40.70.1
Delay disc. indifference point, 2s delay2.02.24.30.71.50.32.11.71.3-1.3-1.81.7-1.80.3-1.6-1.5
Delay disc. indifference point, 24s delay0.10.10.70.80.2-0.30.3-0.1-0.20.20.10.10.3-0.3-0.5-0.5
Delay disc. indifference point, 4s delay0.20.21.60.10.20.30.20.30.3-0.3-0.30.50.6-0.3-1.3-0.7
Delay disc. indifference point, 8s delay1.11.33.11.11.5-1.01.40.90.8-0.8-1.10.9-0.6-1.0-1.4-1.8
Indifference point function ln k0.91.62.70.71.10.61.61.61.4-1.4-1.51.5-1.1-0.2-1.6-0.8
Indifference point function log k0.91.62.70.71.10.61.61.61.4-1.4-1.51.5-1.1-0.2-1.6-0.8
Patch foraging total patch changes 0 sec0.71.33.71.01.90.11.20.80.8-0.8-0.91.3-1.5-1.0-1.6-1.1
Patch foraging total patch changes 12 sec0.60.82.91.71.5-1.20.1-0.5-0.10.10.20.2-0.5-1.0-0.8-1.2
Patch foraging total patch changes 18 sec0.30.41.40.91.2-0.6-0.1-0.5-0.40.40.4-0.0-0.3-1.1-0.7-0.2
Patch foraging total patch changes 24 sec0.81.47.12.51.2-2.7-0.4-0.60.6-0.60.30.6-0.4-0.1-0.1-1.4
Patch foraging total patch changes 6 sec0.20.21.01.00.4-0.8-0.4-0.60.2-0.20.40.3-0.0-0.5-0.1-0.4
Patch foraging time to switch 0 sec1.22.55.7-0.4-1.7-0.9-2.1-2.0-1.71.71.9-1.42.4-0.41.41.1
Patch foraging water rate 0 sec2.04.27.51.72.30.12.72.32.3-2.3-2.32.0-2.40.3-1.9-2.0
Patch foraging water rate 12 sec0.81.64.60.40.70.31.11.51.6-1.6-1.51.2-2.11.4-0.6-0.7
Patch foraging water rate 18 sec4.26.513.01.71.7-1.02.32.73.6-3.6-2.93.2-2.51.1-2.2-2.8
Patch foraging water rate 24 sec4.05.79.91.02.00.22.83.02.6-2.6-3.12.4-3.11.2-2.4-2.4
Patch foraging water rate 6 sec2.13.15.72.02.4-1.12.21.52.0-2.0-1.71.7-2.0-0.2-1.3-1.6
Seeking ratio, delayed vs. immediate footshock0.50.61.60.3-1.2-1.0-1.3-0.70.4-0.40.7-0.00.90.60.80.5
Distance traveled before self-admin0.40.51.5-0.30.11.00.40.70.9-0.9-0.70.80.5-0.6-1.2-0.5
Distance traveled after self-admin0.91.13.51.01.3-0.10.80.71.2-1.2-0.91.3-0.2-1.2-1.9-0.7
Extensor digitorum longus weight0.10.41.61.30.9-0.80.30.00.7-0.7-0.10.8-0.40.2-0.50.6
Bone: elastic displacement0.40.41.8-0.9-1.30.2-0.70.1-0.10.1-0.0-0.00.31.30.7-0.3
Bone: elastic work0.91.23.80.1-0.8-0.3-0.41.01.3-1.3-1.01.4-0.61.9-0.5-1.7
Bone: endosteal estimation1.63.46.71.31.1-1.6-0.9-2.4-2.22.22.2-2.60.5-2.31.61.7
Bone: endosteal perimeter1.32.95.11.61.0-2.0-0.7-2.3-1.91.92.1-2.00.8-2.11.61.0
Epididymis fat weight0.10.51.8-1.20.01.30.30.70.4-0.4-0.60.4-0.70.60.50.6
Delta time in closed arm before/after self-admin0.90.82.4-0.5-1.1-0.2-0.8-0.5-0.90.90.6-1.20.11.31.60.5
Delta time in open arm before/after self-admin1.41.42.51.61.4-0.71.20.91.4-1.4-1.01.5-1.40.8-0.8-0.1
Diff in mean of infusions in LGA sessions0.60.72.2-0.70.91.11.50.7-0.20.2-0.6-0.1-1.0-1.3-0.70.1
Delay discount exponential model param0.20.31.0-0.7-0.60.5-0.5-0.2-0.10.10.3-0.50.00.40.81.0
Extinction: sum of active levers before priming1.11.25.81.91.3-2.4-0.1-0.6-0.40.40.3-0.2-0.40.21.0-1.6
Active lever presses in extinction session 61.01.02.70.11.1-0.7-0.1-1.0-1.71.70.9-1.10.1-1.60.40.4
Bone: final force0.91.42.71.50.6-0.90.60.91.7-1.7-1.01.6-1.21.1-0.7-1.3
Bone: final moment1.11.83.21.60.8-0.90.81.11.8-1.8-1.31.8-1.51.0-1.0-1.5
Food consumed during 24 hour testing period1.01.43.11.51.5-0.60.90.71.6-1.6-0.81.4-0.1-0.2-1.8-0.9
Glucose2.64.26.7-1.3-2.40.6-2.4-2.0-2.62.62.2-2.41.90.32.21.9
Heart weight0.71.23.51.11.6-1.20.80.30.7-0.7-0.60.8-1.0-1.9-1.1-1.1
Delay discount hyperbolic model param0.30.31.2-0.6-0.60.4-0.7-0.4-0.10.10.5-0.50.20.30.91.1
Intermittent access intake day 1-15 change0.81.75.0-2.2-2.01.3-0.80.1-1.21.20.1-1.3-0.31.81.60.1
Intermittent access intake escalation0.81.65.4-2.3-1.91.4-0.70.1-1.21.20.2-1.2-0.21.61.40.1
Intermittent access intake escalation 21.41.63.4-1.2-1.80.1-1.3-0.7-1.51.50.9-1.60.21.71.7-0.3
Intermitt. access day 1 inactive lever presses0.00.10.6-0.00.10.00.30.1-0.30.3-0.1-0.2-0.2-0.10.2-0.8
Intermitt. access day 15 inactive lever presses0.20.41.3-0.8-0.70.30.20.7-0.20.2-0.6-0.1-1.11.10.3-0.3
Intermitt. access escalation Index0.20.30.60.80.3-0.4-0.10.20.7-0.7-0.40.7-0.70.6-0.6-0.1
Intermittent access day 1 total infusions0.20.32.00.10.20.3-0.4-0.4-0.20.20.4-0.11.0-1.4-0.40.4
Intermittent access day 15 total infusions0.30.42.0-1.4-1.01.2-0.60.1-0.60.6-0.0-0.40.20.30.1-0.2
Intermittent access terminal intake (last 3 days)0.20.20.6-0.7-0.70.8-0.60.0-0.50.50.0-0.20.10.2-0.2-0.5
Intermittent access total infusions0.20.21.0-0.7-0.21.0-0.20.30.0-0.0-0.30.40.2-0.5-0.8-0.3
Intermittent access day 1 locomotion0.20.31.2-0.40.50.80.40.40.0-0.0-0.30.10.3-1.1-0.7-0.2
Intermittent access day 15 total locomotion0.30.51.0-0.9-0.01.00.30.90.7-0.7-1.00.2-0.1-0.7-0.8-0.7
Intermittent access total locomotion0.40.51.3-0.60.01.10.20.90.7-0.7-0.90.60.0-0.4-1.1-0.8
Intermittent access standard deviation0.30.61.7-0.8-1.0-0.0-0.9-0.6-0.90.90.7-0.70.20.61.3-0.1
Left kidney weight0.31.43.61.5-0.3-1.6-1.9-1.7-0.70.71.5-0.80.80.31.20.5
Right kidney weight0.73.37.82.1-0.4-2.8-2.4-2.7-1.21.22.5-1.12.1-0.61.70.3
Cocaine induced anxiety1.01.45.7-2.4-2.41.1-1.00.3-0.50.5-0.1-0.3-0.11.61.00.4
Post-drug Anxiety0.60.62.8-1.1-1.70.3-0.70.50.4-0.4-0.50.70.21.3-0.0-0.9
Baseline Anxiety1.01.12.71.71.3-1.10.4-0.01.0-1.0-0.31.20.4-1.1-1.3-1.6
Tail length1.76.630.35.53.1-5.50.2-0.91.4-1.40.21.7-0.4-1.0-0.6-2.5
Length with tail1.46.030.55.53.4-5.30.1-1.30.7-0.70.70.7-1.3-0.40.7-1.6
Length without tail0.41.34.92.21.7-1.5-0.4-1.4-0.70.71.2-0.7-0.6-0.70.71.0
Times rat made contact with spout0.50.52.21.51.4-0.21.20.30.0-0.0-0.20.2-0.1-0.4-0.8-0.4
Lifetime Intake0.10.10.5-0.6-0.00.7-0.30.1-0.00.0-0.20.50.1-0.5-0.5-0.2
Liver weight, left0.71.24.42.02.1-2.10.9-0.10.2-0.2-0.10.1-0.9-1.10.1-0.4
Liver weight, right0.20.41.80.5-0.40.2-1.1-0.8-0.10.10.9-0.31.3-0.00.00.7
Locomotor activity1.11.83.91.51.6-0.61.51.31.3-1.3-1.41.5-2.00.7-0.7-1.1
Locomotor testing distance0.81.42.90.60.7-0.41.21.41.4-1.4-1.51.6-1.71.1-0.7-1.1
Locomotor testing rearing0.40.72.50.91.1-0.81.10.70.7-0.7-0.80.8-1.60.1-0.3-0.5
Locomotion in novel chamber0.50.61.6-0.80.31.3-0.1-0.7-0.60.60.7-0.80.6-1.30.11.2
Locomotion in novel chamber post-restriction0.10.20.70.1-0.5-0.9-0.7-0.20.2-0.20.10.4-0.10.80.4-0.4
Fecal boli incidents, locomotor time 10.30.41.8-0.4-0.7-0.6-0.5-0.2-0.10.10.2-0.00.51.21.4-0.3
Change in fecal boli incidents, locomotor task2.02.03.9-1.1-1.10.4-1.2-1.3-1.91.91.5-2.01.8-1.20.71.0
Time >=10cm from walls, locomotor time 11.21.33.2-0.3-0.5-1.7-1.3-1.2-1.51.51.1-1.10.3-0.11.80.1
Bouts of movement, locomotor time 12.22.55.11.1-0.1-1.8-1.8-2.3-2.12.12.1-1.61.5-0.90.80.1
Total resting periods, locomotor time 12.22.45.11.2-0.2-2.1-2.0-2.3-1.91.92.0-1.41.5-0.80.9-0.0
Rest time, locomotor task time 11.41.84.1-0.1-1.1-1.0-2.0-1.8-1.41.41.7-1.22.0-0.21.10.1
Distance moved, locomotor task time 10.81.23.60.70.70.31.11.21.4-1.4-1.11.2-1.91.3-0.5-0.2
Vertical activity count, locomotor time 10.30.71.6-0.60.01.20.71.10.8-0.8-0.90.6-1.30.9-0.50.1
Time >=10cm from walls, locomotor time 20.60.82.60.0-0.2-0.60.31.11.2-1.2-1.01.0-1.01.60.2-0.4
Bouts of movement, locomotor time 20.50.74.8-0.10.90.41.0-0.1-0.70.70.1-0.80.5-2.2-1.0-0.3
Total resting periods, locomotor time 20.50.95.8-0.20.60.30.7-0.4-1.01.00.4-1.00.8-2.4-0.8-0.1
Rest time, locomotor task time 22.93.78.1-1.8-2.30.2-1.4-1.5-2.62.61.7-2.81.51.02.80.8
Distance moved, locomotor task time 22.32.77.01.81.2-0.60.51.22.5-2.5-1.42.6-1.80.9-1.6-0.9
Vertical activity count, locomotor time 20.70.93.00.20.30.7-0.30.61.7-1.7-0.81.7-0.80.2-1.00.4
Light reinforcement 14.110.016.43.83.0-2.52.72.64.0-4.0-3.04.1-3.31.4-2.5-3.3
Light reinforcement 22.43.68.01.31.1-0.31.32.12.6-2.6-2.22.8-1.91.0-1.7-1.9
Bone: marrow area1.63.67.01.41.1-1.7-0.9-2.4-2.32.32.3-2.60.5-2.31.61.6
Bone: maximum diameter2.13.97.41.30.5-1.9-1.3-2.7-2.42.42.6-2.41.2-1.92.11.5
Bone: maximum force0.30.52.71.3-0.0-1.6-0.3-0.30.5-0.50.10.50.2-0.2-0.2-0.8
Bone: maximum moment0.30.52.61.30.2-1.6-0.1-0.00.6-0.6-0.20.7-0.1-0.2-0.5-1.0
Mean time between licks in bursts1.02.57.7-1.8-2.80.3-1.8-1.1-1.51.51.4-1.71.90.81.70.8
Mean num. licks in bursts1.01.56.32.52.4-1.81.4-0.2-0.10.1-0.00.2-1.2-0.9-0.10.0
Cd content in liver0.20.31.11.10.1-0.6-0.4-0.3-0.30.30.3-0.3-0.10.4-0.2-1.0
Co content in liver1.41.65.82.41.3-2.2-0.3-1.4-0.80.81.2-0.60.6-1.7-0.1-0.2
Cu content in liver0.70.81.9-0.60.50.81.31.40.7-0.7-1.30.8-1.2-0.0-0.8-0.7
Fe content in liver1.01.23.80.1-0.3-0.9-0.6-1.4-1.21.21.3-1.01.3-1.90.51.0
K content in liver0.50.51.90.21.40.41.10.50.5-0.5-0.60.4-0.7-1.0-0.6-0.1
Mg content in liver0.80.93.31.01.8-0.21.40.40.4-0.4-0.50.5-0.3-1.4-1.3-0.2
Mn content in liver0.60.71.61.31.2-0.60.70.50.6-0.6-0.60.8-0.3-0.4-1.2-1.2
Na content in liver0.60.62.30.71.5-0.51.10.3-0.30.3-0.50.1-0.8-1.5-0.5-0.5
Rb content in liver1.01.15.32.31.5-1.60.50.20.8-0.8-0.40.9-0.90.4-0.6-0.8
Se content in liver0.20.21.2-0.10.2-0.21.10.80.3-0.3-0.70.2-0.00.3-0.0-0.2
Sr content in liver0.80.72.80.3-0.9-1.5-1.1-0.7-0.30.30.6-0.50.40.81.70.1
Zn content in liver0.20.21.7-0.50.20.41.30.6-0.30.3-0.5-0.3-0.40.00.2-0.2
Bone: minimum diameter1.93.46.91.70.5-2.0-1.4-2.6-2.12.12.5-2.21.1-1.91.51.4
Time in familiar zone, hab. session 10.60.52.40.6-0.2-1.6-0.3-0.8-0.60.60.8-0.31.0-0.50.8-0.1
Time in novel zone, hab. session 10.20.21.3-0.3-0.20.8-0.40.1-0.00.0-0.0-0.0-0.71.20.40.4
Total zone transitions, hab. session 10.60.83.0-1.7-0.81.30.20.2-1.11.10.1-0.80.8-0.70.11.1
Total locomotion distance, hab. session 11.31.88.3-2.9-2.02.3-0.30.3-0.80.80.0-0.81.30.40.31.3
Locomotion velocity, hab. session 11.01.46.5-2.6-1.62.40.10.6-0.50.5-0.3-0.51.00.3-0.11.1
Time in familiar zone, hab. session 20.40.41.40.61.1-0.31.20.30.3-0.3-0.30.50.0-1.0-0.6-0.1
Time in novel zone, hab. session 20.40.42.6-0.3-0.70.1-0.40.40.5-0.5-0.40.3-0.61.60.1-0.5
Total zone transitions, hab. session 20.91.12.7-1.00.71.01.61.60.9-0.9-1.60.9-0.9-0.3-1.0-0.3
Total locomotion distance, hab. session 21.11.43.6-1.9-0.31.71.41.80.9-0.9-1.60.6-0.60.8-0.9-0.2
Locomotion velocity, hab. session 20.91.33.3-1.8-0.31.61.11.71.0-1.0-1.60.7-0.60.8-0.8-0.3
Novel to familiar place preference ratio2.22.47.3-0.8-2.1-1.2-2.7-1.6-1.11.11.5-1.30.71.42.30.2
Novelty place preference2.72.98.1-0.6-2.0-1.5-2.8-2.0-1.51.51.8-1.60.71.22.60.3
Time in novel zone, NPP test2.22.36.8-0.6-1.8-1.3-2.6-1.7-1.31.31.6-1.40.61.12.30.3
Total zone transitions, NPP test1.11.65.1-1.31.11.52.31.70.6-0.6-1.60.8-0.9-1.3-1.5-0.0
Total locomotion distance, NPP test0.71.02.7-0.80.31.21.21.30.9-0.9-1.31.0-0.3-0.1-1.6-0.3
Locomotion velocity, NPP test0.60.82.3-0.60.20.91.01.20.9-0.9-1.21.1-0.20.0-1.5-0.5
Intraocular pressure0.60.81.7-0.7-0.80.60.51.31.0-1.0-1.21.0-0.41.1-1.0-0.7
Delta distance traveled before/after self-admin1.71.74.51.92.1-1.31.20.61.1-1.1-0.91.4-1.7-0.6-1.3-1.0
Delta ambulatory time before/after self-admin0.70.93.01.41.4-0.61.00.50.8-0.8-0.60.8-1.70.0-0.7-0.3
Parametrial fat weight0.40.91.9-0.1-0.8-0.4-1.1-1.1-1.41.41.2-1.00.90.20.90.8
Pavlov. Cond. lever latency1.01.33.00.6-1.6-1.1-1.7-1.1-0.90.91.1-0.91.60.90.6-0.6
Pavlov. Cond. magazine entry latency0.30.41.5-0.60.90.80.70.0-0.30.30.0-0.3-0.3-1.20.00.7
Pavlov. Cond. change in total contacts1.61.74.3-0.92.11.51.81.10.8-0.8-1.20.5-1.8-1.9-0.80.7
Pavlov. Cond. index score0.50.72.4-0.41.60.61.30.60.5-0.5-0.70.5-1.2-1.0-0.30.3
Pavlov. Cond. latency score0.40.52.0-0.21.40.21.00.40.6-0.6-0.50.5-1.1-0.9-0.10.3
Pavlov. Cond. lever contacts0.60.72.1-0.61.50.71.20.60.6-0.6-0.70.5-1.3-1.2-0.30.6
Pavlov. Cond. magazine entry number1.01.23.11.1-1.6-1.8-1.7-0.80.0-0.00.70.21.41.60.5-0.6
Pavlov. Cond. intertrial magazine entries1.41.72.91.30.4-0.61.41.51.7-1.7-1.51.7-0.71.3-1.3-1.2
Pavlov. Cond. lever-magazine prob. diff.0.70.82.5-0.71.61.01.30.70.5-0.5-0.70.5-1.2-1.2-0.40.5
Pavlov. Cond. response bias1.11.43.5-0.91.91.51.91.00.4-0.4-1.00.3-1.6-1.5-0.70.5
Pavlov. Cond. lever latency0.30.41.8-0.6-1.2-0.3-0.7-0.4-0.40.40.5-0.21.30.00.60.3
Pavlov. Cond. magazine entry latency1.01.22.7-0.10.91.11.21.41.1-1.1-1.41.0-1.20.4-1.6-0.8
Pavlov. Cond. change in total contacts0.50.83.40.01.30.91.00.90.6-0.6-1.00.6-1.80.1-0.9-0.4
Pavlov. Cond. index score0.50.72.00.01.01.01.01.00.6-0.6-1.00.4-1.40.4-0.9-0.4
Pavlov. Cond. latency score0.50.71.80.10.90.81.01.00.7-0.7-1.00.5-1.30.4-0.9-0.5
Pavlov. Cond. lever contacts0.20.31.40.61.00.10.40.20.4-0.4-0.40.2-1.20.0-0.6-0.3
Pavlov. Cond. magazine entry number1.41.83.90.4-0.6-1.2-1.4-1.8-1.21.21.8-1.12.0-1.31.31.1
Pavlov. Cond. intertrial magazine entries0.40.51.80.60.1-0.1-0.20.61.1-1.1-0.61.3-0.71.0-0.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.71.8-0.20.81.11.01.00.6-0.6-1.00.4-1.40.4-0.9-0.3
Pavlov. Cond. response bias0.30.52.20.10.90.70.60.60.4-0.4-0.70.3-1.50.3-0.7-0.4
Time in closed arm before self-admin0.60.83.5-0.10.90.70.80.70.8-0.8-0.81.2-0.7-0.9-1.9-0.5
Time in closed arm after self-admin0.30.31.0-1.0-0.50.70.10.2-0.80.8-0.1-0.4-0.7-0.1-0.1-0.4
Time in open arm before self-admin0.70.82.6-0.5-1.2-0.3-1.6-0.8-0.50.50.8-0.71.60.20.8-0.3
Time in open arm after self-admin0.80.85.32.31.1-1.60.0-0.40.7-0.70.20.50.50.3-0.20.0
Bone: periosteal estimation1.42.95.21.60.9-1.8-1.0-2.3-1.91.92.1-2.10.7-2.01.31.3
Bone: periosteal perimeter1.32.36.72.41.7-2.6-0.2-1.8-0.90.91.5-0.90.3-2.40.70.3
Bone: post-yield work2.13.18.20.2-0.8-1.2-1.3-2.2-1.81.82.2-1.92.9-2.50.71.6
Progressive ratio test 1 active lever presses0.10.10.7-0.00.20.30.1-0.1-0.30.30.2-0.20.7-0.9-0.10.4
Progressive ratio test 1 breakpoint0.10.10.70.10.20.20.1-0.2-0.20.20.2-0.20.6-0.9-0.10.3
Progressive ratio test 1 inactive lever presses0.10.10.4-0.10.2-0.2-0.1-0.1-0.60.60.1-0.3-0.3-0.30.2-0.2
Progressive ratio test 2 active lever presses1.11.33.2-0.30.61.11.11.41.1-1.1-1.41.2-0.7-0.8-1.8-0.9
Progressive ratio test 2 breakpoint1.31.53.8-0.30.71.21.31.51.2-1.2-1.51.3-0.7-0.9-1.9-0.9
Progressive ratio test 2 inactive lever presses0.10.20.8-0.9-0.40.80.20.4-0.60.6-0.2-0.40.0-0.4-0.20.0
Incentive Sensitization - Responses2.53.68.1-0.00.91.21.52.22.6-2.6-2.32.4-1.3-0.4-2.8-1.6
Incentive Sensitization - Breakpoint3.24.19.2-0.01.01.31.72.42.7-2.7-2.52.5-1.5-0.4-3.0-1.7
Sum of active levers in priming session hrs 5-61.51.44.00.72.0-0.51.6-0.0-1.71.70.0-0.8-0.8-1.8-0.0-0.6
Progressive ratio0.91.43.40.80.8-1.10.60.81.7-1.7-1.01.8-0.2-0.3-1.3-1.6
Food seeking constrained by brief footshock1.11.42.8-0.5-0.20.70.91.41.6-1.6-1.41.6-0.40.4-1.7-1.3
Seeking ratio, punishment vs. effort0.10.11.0-0.4-0.31.00.00.1-0.10.10.0-0.3-0.10.1-0.30.6
Retroperitoneal fat weight0.41.64.2-2.1-0.41.61.01.60.5-0.5-1.30.4-1.71.91.20.4
Reaction time number correct1.22.34.9-1.9-1.31.50.61.91.8-1.8-1.71.5-1.12.2-0.4-0.1
Reaction time mean minus median0.30.72.1-1.3-0.30.5-0.5-0.7-0.50.50.7-0.71.0-1.40.21.5
Reaction time mean minus median AUC0.20.62.1-1.3-0.20.7-0.7-0.6-0.30.30.5-0.40.8-1.5-0.11.3
Reaction time num false alarms1.82.65.3-0.90.01.41.42.21.9-1.9-2.11.9-1.30.6-2.3-1.1
Reaction time num false alarms AUC1.93.06.6-0.90.21.41.52.32.0-2.0-2.32.2-1.40.5-2.6-1.4
Reaction time trials correct on left1.22.34.9-1.9-1.31.50.61.91.8-1.8-1.71.5-1.12.2-0.4-0.1
Reaction time trials on left1.22.34.4-2.0-1.31.70.61.91.8-1.8-1.71.4-1.12.1-0.40.0
Reaction time mean0.60.96.8-0.60.60.30.2-0.5-0.70.70.5-0.60.8-2.6-0.71.2
Reaction time mean AUC0.71.27.2-0.80.50.40.0-0.8-1.01.00.7-0.81.0-2.7-0.41.5
Median of all reaction times0.60.86.3-0.30.80.20.5-0.4-0.80.80.3-0.50.5-2.5-0.81.0
Reaction time omissions2.02.97.8-2.8-0.52.70.7-0.2-1.61.60.6-1.71.2-2.30.52.7
Reaction time false alarm rate1.01.45.10.20.90.61.21.31.1-1.1-1.41.4-0.8-0.5-2.3-1.4
Reaction time premature initiation rate0.60.82.80.31.0-0.40.3-0.7-1.31.30.8-1.7-0.5-1.00.90.4
Reaction time premature initiations0.20.31.0-0.70.20.30.60.3-0.30.3-0.2-0.8-1.00.40.80.4
Std. dev. reaction times0.61.13.6-1.7-0.21.3-0.3-0.4-0.60.60.4-0.70.9-1.9-0.31.7
Reaction time trials completed1.22.34.4-2.0-1.31.70.61.91.8-1.8-1.71.4-1.12.1-0.40.0
Reaction time trials AUC1.32.55.2-2.0-1.31.70.82.01.9-1.9-1.81.5-1.32.3-0.4-0.1
Run reversals in cocaine runway, females0.80.84.51.40.8-2.1-0.6-0.4-0.20.20.10.2-0.80.2-0.0-1.3
Run reversals in cocaine runway, males1.01.02.2-0.21.50.81.30.91.5-1.5-0.91.1-0.9-0.5-0.50.2
Latency to leave start box in cocaine runway0.50.62.4-0.80.51.40.70.2-0.70.7-0.1-0.50.4-1.5-0.60.6
Latency to leave start box in cocaine runway, F0.20.21.30.10.40.30.5-0.1-0.30.30.10.10.7-1.1-0.50.5
Latency to leave start box in cocaine runway, M1.31.22.9-1.7-0.61.7-0.5-0.4-1.61.60.6-1.50.7-0.80.40.8
Std. dev. time between licks in bursts0.91.23.6-1.5-1.90.6-1.2-0.9-1.21.21.0-1.21.30.20.70.7
Total sessions with >9 infusions0.20.20.80.30.9-0.1-0.1-0.2-0.40.40.00.3-0.5-0.8-0.2-0.5
Short access day 1 total inactive lever presses0.20.20.9-0.40.10.20.10.6-0.10.1-0.60.2-0.90.2-0.2-0.9
Short access day 10 total inactive lever presses0.20.61.2-0.8-0.40.50.71.10.3-0.3-1.00.2-1.10.9-0.4-1.0
Short access day 1 total infusions0.10.20.60.60.6-0.4-0.3-0.3-0.20.20.20.2-0.80.10.2-0.1
Short access day 10 total infusions0.70.92.1-0.6-0.70.7-1.3-1.1-1.01.01.1-0.60.9-0.90.51.4
Short access total infusions0.20.20.6-0.30.10.1-0.8-0.6-0.70.70.5-0.00.1-0.70.20.2
Short access day 1 locomotion0.30.41.3-0.70.20.4-0.1-0.3-1.11.10.3-0.7-0.5-0.30.70.4
Short access day 10 total locomotion0.10.30.9-0.1-0.2-0.3-0.9-0.8-0.30.30.7-0.40.5-0.50.50.4
Short access total locomotion0.10.10.40.00.5-0.2-0.4-0.2-0.00.0-0.00.4-0.5-0.6-0.1-0.3
One hour access (0.3 mA shock)0.81.03.80.50.9-0.30.81.00.9-0.9-1.10.7-2.01.0-0.1-1.2
Compulsive drug intake1.01.13.11.71.7-1.41.20.41.0-1.0-0.60.9-1.0-0.5-0.7-0.5
One hour access (shock baseline)0.10.20.6-0.5-0.60.3-0.70.20.3-0.3-0.30.4-0.50.80.2-0.6
Social response proportion0.50.61.80.10.4-0.2-0.7-0.9-1.01.00.9-0.80.0-0.60.71.3
Social responses0.30.41.7-0.10.50.30.20.30.5-0.5-0.40.6-1.31.10.50.8
Social time1.01.44.00.3-1.2-0.6-1.8-1.5-1.01.01.6-0.52.0-0.00.41.1
Soleus weight1.44.211.33.43.1-1.71.60.92.4-2.4-1.22.2-1.5-0.5-2.3-1.1
Bone: stiffness0.10.20.80.3-0.5-0.9-0.5-0.60.1-0.10.50.10.6-0.80.10.0
Tibialis anterior weight2.27.615.23.23.9-1.62.52.03.2-3.2-2.43.2-3.40.3-2.6-2.1
Time to tail flick, vehicle, before self-admin0.30.31.4-1.2-0.80.9-0.00.3-0.50.5-0.20.20.60.5-0.1-0.0
Time to tail flick, vehicle, after self-admin1.21.65.5-2.4-0.92.30.71.0-0.80.8-0.7-0.8-1.51.40.80.5
Time to tail flick, test, before self-admin0.80.83.1-1.6-1.81.2-0.70.10.1-0.10.10.20.41.40.60.6
Time to tail flick, test, after self-admin1.21.23.6-1.5-1.91.5-1.2-0.5-0.50.50.7-0.81.01.40.51.1
Delta time to tail flick, vehicle, before/after SA0.80.72.7-0.9-0.31.60.71.00.4-0.4-0.7-0.3-1.31.20.30.5
Delta time to tail flick, test, before/after SA0.10.20.60.0-0.30.2-0.8-0.5-0.00.00.5-0.50.60.2-0.20.5
Tibia length0.41.14.31.1-0.8-2.1-1.7-0.90.6-0.60.60.70.11.11.1-0.8
Ambulatory time before self-admin0.40.61.5-0.10.30.50.40.81.0-1.0-0.80.90.5-0.8-1.2-1.1
Ambulatory time after self-admin1.92.25.81.21.8-0.21.31.21.9-1.9-1.41.8-0.9-0.9-2.4-1.2
Bone: tissue strength1.61.63.6-0.3-0.10.61.51.91.7-1.7-1.81.5-0.40.7-1.5-0.8
Total heroin consumption0.70.84.4-0.11.40.10.4-0.6-1.01.00.6-0.7-0.0-2.1-0.30.8
Bone: trabecular number0.30.52.30.81.2-0.70.60.00.3-0.3-0.20.5-0.3-1.5-0.80.1
Bone: trabecular spacing1.41.94.61.0-0.1-1.00.31.11.8-1.8-1.21.9-0.42.1-0.8-2.1
Bone: trabecular thickness0.70.93.40.10.2-0.9-0.3-1.0-1.11.10.9-1.10.3-1.90.90.9
Bone: trabecular tissue density0.40.61.10.90.7-0.6-0.3-1.0-1.01.01.0-0.5-0.30.20.90.5
Water consumed over 24 hours2.02.77.11.32.10.42.72.01.5-1.5-1.91.6-1.70.2-1.8-0.9
Number of responses in last shaping day0.10.20.40.40.1-0.4-0.5-0.4-0.50.50.4-0.2-0.30.00.60.4