Srp19

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	intron excision ratio	chr18_26210344_26211679	0.22	0.12	7.4e-03	0.01	0.06	-0.02	0	1.9e-01	4.6e-02	9.1e-01	2.8e-01
2	Eye	intron excision ratio	chr18_26210140_26210233	0.22	0.11	5.9e-03	0.03	0.07	-0.02	0	1.3e-01	3.4e-02	7.8e-01	2.9e-01
3	Liver	gene expression	Srp19	0.05	0.04	5.0e-04	0.01	0.01	0.01	0.01	8.4e-03	6.8e-03	4.3e-02	1.3e-02
4	Adipose	gene expression	Srp19	0.07	0.05	1.5e-04	0.03	0.02	0.01	0.03	4.7e-04	2.3e-03	9.5e-03	8.3e-04
5	Liver	intron excision ratio	chr18_26205937_26210069	0.03	0.02	3.9e-04	0.02	0.02	0.02	0.02	2.0e-03	1.7e-03	1.5e-03	2.6e-03
6	BLA	gene expression	Srp19	0.47	0.05	5.7e-03	0	-0	0.05	-0	2.0e-01	8.7e-01	1.4e-03	6.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	0.7	0.7	-0.5	0.2	-0.6	0.8	0.2
Area under the delay curve	2.8	3.3	4.9	2.2	-2.2	-1.8	-1.8	1.5	1.2
BMI with tail	8.5	29.2	46.1	-6.8	6.6	6.6	5.5	-3.5	-0.5
BMI without tail	6.7	20.5	29.4	-5.4	5.4	5.3	4.5	-3.9	-0.9
Body weight	7.5	32.8	50.3	-7.1	7.0	7.0	5.8	-3.7	-1.1
Weight adjusted by age	3.0	4.5	6.5	-2.5	2.5	2.4	2.4	-1.5	-0.5
Bone surface	0.5	1.0	1.8	1.1	-1.0	-0.3	-1.3	1.0	0.9
Bone volume	0.3	0.5	0.9	0.8	-0.7	-0.0	-0.9	1.0	0.5
Breakpoint value in progressive ratio session	0.4	0.4	2.0	0.5	-0.4	-0.4	0.1	0.1	-1.4
Number of licking bursts	0.8	1.2	1.7	1.2	-1.2	-1.3	-0.9	0.9	0.9
Context. condit. distance diff. score	0.3	0.3	1.5	0.1	-0.1	-0.1	-0.3	-0.7	1.2
Locomotion velocity, session 1	0.7	0.7	4.1	-0.1	0.2	0.1	0.1	-0.6	-2.0
Locomotion distance, session 1	0.2	0.2	1.0	0.1	-0.1	-0.3	-0.1	-1.0	-0.4
Locomotion velocity, session 2	0.7	0.8	1.4	-1.2	1.1	0.6	-0.0	-0.4	-1.2
Locomotion distance, session 2	0.5	0.8	1.3	0.9	-0.9	-1.1	-1.1	0.6	0.0
Locomotion velocity, session 3	0.2	0.2	1.0	-0.3	0.3	0.2	0.3	-1.0	0.3
Locomotion distance, session 3	0.5	0.5	1.9	0.6	-0.5	-0.1	-0.8	-0.3	1.4
Stereotopy head waving bouts, day 3	1.8	2.1	3.3	1.8	-1.8	-1.8	-0.9	1.5	0.5
Stereotopy head waving duration, day 3	0.4	0.4	1.2	0.5	-0.5	-0.9	0.3	0.3	-1.1
Locomotion velocity, session 7	0.4	0.4	1.0	-0.4	0.5	1.0	0.2	-0.5	0.8
Locomotion distance, session 7	0.5	0.6	2.7	0.5	-0.4	0.4	-0.5	0.3	1.6
Stereotopy head waving bouts, day 7	0.7	0.8	2.8	-0.9	0.8	0.3	0.7	-0.1	-1.7
Stereotopy head waving duration, day 7	0.3	0.3	1.2	-0.6	0.4	-0.4	0.2	-0.0	-1.1
Locomotion velocity, session 8	0.4	0.4	1.7	-0.6	0.5	-0.3	0.0	-0.3	-1.3
Locomotion distance, session 8	0.1	0.2	0.5	0.3	-0.3	-0.5	-0.3	-0.7	0.6
Degree of sensitization distance	0.5	0.5	1.1	-0.8	0.8	1.0	0.6	-0.0	-0.3
Degree of sensitization stereotypy	0.5	0.6	2.3	-0.8	0.7	0.0	0.2	0.1	-1.5
Conditioned locomotion	0.3	0.3	1.2	-0.2	0.2	0.7	0.1	0.4	1.1
Cocaine response after cond. corrected	0.4	0.5	1.8	-0.4	0.5	0.6	0.8	-1.3	0.2
Cocaine response after cond. not corrected	0.2	0.2	0.7	0.3	-0.3	-0.5	0.0	-0.5	0.9
Cocaine response before conditioning	4.6	5.5	7.6	1.9	-2.2	-2.8	-2.5	2.4	2.2
Saline control response	0.8	1.0	2.1	0.6	-0.7	-1.0	-1.1	1.5	1.0
Bone: connectivity density	1.4	2.2	3.4	1.8	-1.7	-1.1	-1.9	1.3	0.7
Bone: cortical apparent density	0.4	0.5	1.1	0.7	-0.7	-1.0	-0.6	0.6	0.4
Bone: cortical area	1.7	2.6	6.8	1.6	-1.5	-0.9	-1.3	1.2	2.6
Bone: cortical porosity	0.4	0.5	0.7	-0.7	0.8	0.6	0.8	-0.8	-0.3
Bone: cortical porosity	0.3	0.3	0.5	-0.6	0.7	0.7	0.5	-0.6	-0.0
Bone: cortical thickness	1.4	2.4	8.7	1.1	-1.1	-0.5	-0.9	1.4	3.0
Bone: cortical thickness	0.2	0.2	0.6	0.1	-0.2	0.2	-0.0	0.7	0.8
Bone: cortical tissue density	0.3	0.4	1.0	0.6	-0.6	-1.0	-0.5	0.5	0.3
Condit. Reinf. active minus inactive responses	2.6	2.9	4.1	2.0	-2.0	-1.8	-1.9	1.1	1.2
Condit. Reinf. active-inactive response ratio	1.4	1.4	2.8	1.1	-1.2	-0.9	-1.4	0.8	1.7
Condit. Reinf. active responses	3.4	4.2	6.9	2.6	-2.3	-2.2	-2.6	0.8	0.9
Condit. Reinf. inactive responses	2.3	2.8	5.4	2.1	-1.9	-1.7	-2.3	0.7	0.1
Incentive salience index mean	2.2	2.8	4.3	2.1	-2.0	-2.0	-1.8	0.9	0.7
Condit. Reinf. lever presses	1.2	1.7	2.9	1.7	-1.6	-1.6	-1.3	0.4	0.1
Condit. Reinf. active minus inactive responses	3.9	5.0	8.6	2.9	-2.8	-2.9	-1.4	1.7	0.6
Condit. Reinf. active-inactive response ratio	0.5	0.6	1.3	0.9	-0.7	-0.6	0.7	-0.6	-1.2
Condit. Reinf. active responses	8.8	12.3	19.6	4.1	-4.2	-4.4	-2.8	2.9	1.9
Condit. Reinf. inactive responses	8.6	11.2	16.1	3.4	-3.6	-4.0	-3.1	3.2	2.5
Condit. Reinf. lever presses	2.4	3.3	5.6	2.4	-2.2	-2.1	-1.5	1.4	1.0
Condit. Reinf. lever reinforcers received	7.9	11.0	18.8	3.9	-3.9	-4.3	-2.5	2.8	1.5
Conditioned reinforcement - actives	0.2	0.3	0.8	-0.2	0.2	-0.2	-0.0	-0.9	-0.9
Conditioned reinforcement - inactives	0.4	0.6	1.4	0.6	-0.7	-0.7	-1.2	0.2	0.9
Conditioned locomotion	0.1	0.2	0.3	0.1	-0.1	-0.4	-0.4	-0.6	-0.5
Patch foraging indifference point 0 sec	1.8	3.2	4.4	1.7	-1.8	-2.1	-1.8	1.4	1.9
Patch foraging indifference point AUC	2.8	4.1	6.1	2.5	-2.4	-2.0	-2.0	1.9	-0.9
Delay disc. indifference point, 0s delay	1.2	1.3	1.7	1.3	-1.3	-1.0	-1.3	0.9	1.2
Delay disc. indifference point, 16s delay	3.1	3.4	4.4	2.0	-2.1	-1.8	-1.9	1.9	1.1
Delay disc. indifference point, 2s delay	0.4	0.4	0.9	1.0	-0.9	-0.4	-0.5	0.7	-0.0
Delay disc. indifference point, 24s delay	0.6	0.7	1.3	1.1	-1.1	-0.7	-1.0	0.2	0.2
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	1.1	-1.0	-0.6	-0.3	0.5	-0.4
Delay disc. indifference point, 8s delay	4.4	5.1	6.8	2.6	-2.6	-2.2	-2.4	1.5	2.1
Indifference point function ln k	6.3	11.1	17.2	-4.1	4.1	3.5	3.4	-3.0	-0.5
Indifference point function log k	6.3	11.1	17.2	-4.1	4.1	3.5	3.4	-3.0	-0.5
Patch foraging total patch changes 0 sec	1.6	3.0	4.1	1.7	-1.8	-2.0	-1.8	1.3	1.7
Patch foraging total patch changes 12 sec	8.8	11.4	15.1	3.8	-3.9	-3.8	-3.4	2.6	2.5
Patch foraging total patch changes 18 sec	3.8	5.8	9.3	3.0	-2.9	-2.0	-2.9	2.0	0.6
Patch foraging total patch changes 24 sec	2.0	3.4	4.1	1.9	-2.0	-1.7	-2.0	1.6	1.7
Patch foraging total patch changes 6 sec	3.5	5.4	7.7	2.8	-2.8	-2.5	-2.2	1.8	1.5
Patch foraging time to switch 0 sec	0.2	0.4	0.9	-0.3	0.4	0.3	0.9	-1.0	-0.7
Patch foraging water rate 0 sec	0.1	0.1	0.6	-0.0	0.0	0.0	-0.3	0.2	0.8
Patch foraging water rate 12 sec	0.3	0.7	1.3	-0.8	0.8	1.1	-0.3	-1.0	0.6
Patch foraging water rate 18 sec	0.1	0.1	0.4	-0.1	0.2	-0.1	-0.2	-0.7	0.4
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.2	-0.0	-0.2	-0.2	-0.6	0.3
Patch foraging water rate 6 sec	0.1	0.1	0.3	0.3	-0.1	0.1	-0.5	-0.5	0.5
Seeking ratio, delayed vs. immediate footshock	0.9	1.0	2.1	1.0	-1.1	-1.4	-0.7	1.2	-0.5
Distance traveled before self-admin	0.4	0.5	1.6	0.5	-0.4	0.5	0.6	0.4	-1.3
Distance traveled after self-admin	2.0	2.5	5.4	2.3	-2.1	-1.8	-1.1	0.1	-0.7
Extensor digitorum longus weight	2.4	9.6	14.7	-3.8	3.7	3.6	3.0	-2.6	-0.3
Bone: elastic displacement	1.0	1.2	4.4	-0.7	0.8	0.4	1.2	-2.1	-0.1
Bone: elastic work	1.6	2.1	5.0	-1.5	1.5	0.8	1.6	-2.2	0.1
Bone: endosteal estimation	0.5	1.1	1.6	1.3	-1.2	-1.2	-1.3	0.2	0.7
Bone: endosteal perimeter	0.0	0.1	0.2	0.4	-0.4	-0.3	-0.3	-0.2	0.3
Epididymis fat weight	2.2	7.6	9.8	-3.1	3.1	2.3	2.9	-2.9	-2.0
Delta time in closed arm before/after self-admin	1.5	1.4	2.5	-1.4	1.3	0.6	1.6	-1.0	-0.8
Delta time in open arm before/after self-admin	0.7	0.7	1.7	-0.2	0.2	0.9	-0.4	1.3	1.0
Diff in mean of infusions in LGA sessions	0.4	0.4	2.2	0.3	-0.1	-0.4	-0.0	-1.5	-0.4
Delay discount exponential model param	2.8	3.1	4.8	-2.2	2.2	1.7	1.8	-1.4	-1.1
Extinction: sum of active levers before priming	0.3	0.4	1.0	-0.2	0.3	0.7	0.8	-0.2	-1.0
Active lever presses in extinction session 6	2.0	2.0	3.0	1.6	-1.6	-1.4	-1.7	0.9	1.0
Bone: final force	0.5	0.7	2.6	0.5	-0.5	-0.1	-0.4	1.1	1.6
Bone: final moment	0.2	0.4	1.7	0.2	-0.2	0.1	-0.2	0.6	1.3
Food consumed during 24 hour testing period	0.7	0.9	2.8	-1.0	1.1	1.7	0.2	-0.3	-0.7
Glucose	6.9	10.9	13.9	-3.1	3.3	3.2	3.7	-3.2	-3.3
Heart weight	2.2	3.4	6.2	-2.5	2.4	2.3	1.5	-0.8	-0.6
Delay discount hyperbolic model param	2.8	3.1	4.9	-2.2	2.2	1.7	1.7	-1.5	-1.0
Intermittent access intake day 1-15 change	0.3	0.7	1.7	-1.3	1.1	0.5	0.8	0.2	0.4
Intermittent access intake escalation	0.4	0.8	1.9	-1.4	1.2	0.5	1.0	0.3	0.3
Intermittent access intake escalation 2	0.9	1.0	2.1	-1.4	1.3	0.8	1.3	0.1	0.1
Intermitt. access day 1 inactive lever presses	0.2	0.7	1.7	0.8	-0.8	-1.0	-0.3	1.3	-0.3
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.5	0.2	-0.3	-0.6	-0.5	-0.3	0.7
Intermitt. access escalation Index	0.2	0.3	0.4	-0.6	0.6	0.5	0.6	-0.5	-0.3
Intermittent access day 1 total infusions	0.6	1.0	2.7	1.0	-1.0	-1.7	-0.7	-0.2	-0.7
Intermittent access day 15 total infusions	0.2	0.3	1.6	0.1	-0.2	-1.3	-0.0	-0.4	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	1.0	-0.3	0.1	-1.0	-0.0	-0.2	0.1
Intermittent access total infusions	0.4	0.5	0.9	-0.1	0.1	-0.8	0.3	-1.0	-1.0
Intermittent access day 1 locomotion	0.6	0.8	1.8	0.8	-0.7	-1.3	-0.6	-0.7	-0.9
Intermittent access day 15 total locomotion	0.5	0.9	2.0	-1.2	1.2	0.5	0.7	-1.4	-0.4
Intermittent access total locomotion	0.4	0.4	1.2	-0.5	0.5	-0.3	0.4	-1.1	-0.8
Intermittent access standard deviation	0.3	0.7	1.7	-0.9	0.8	-0.1	1.0	0.0	-1.3
Left kidney weight	0.4	1.8	2.5	-1.4	1.6	1.6	1.4	-1.4	0.1
Right kidney weight	0.1	0.3	0.6	-0.6	0.6	0.7	0.2	-0.2	0.7
Cocaine induced anxiety	0.4	0.5	1.3	-0.1	0.3	0.6	1.1	-0.6	-1.1
Post-drug Anxiety	1.2	1.3	2.4	-1.0	1.1	1.5	1.3	-0.1	-1.3
Baseline Anxiety	0.9	1.1	2.5	-1.6	1.4	1.3	-0.0	0.3	0.2
Tail length	0.1	0.4	1.3	-0.4	0.6	0.4	0.3	-1.1	-0.7
Length with tail	0.7	3.2	4.7	-2.1	2.2	2.0	1.8	-1.2	-1.0
Length without tail	0.7	2.1	3.2	-1.8	1.7	1.7	1.7	-0.2	-0.8
Times rat made contact with spout	0.2	0.2	0.6	0.2	0.0	0.8	-0.8	-0.2	-0.1
Lifetime Intake	0.7	0.9	2.0	-0.4	0.4	-0.7	0.7	-1.4	-1.4
Liver weight, left	1.0	1.7	4.5	1.5	-1.4	-2.1	-0.7	0.4	-1.1
Liver weight, right	2.6	4.5	8.7	2.3	-2.3	-2.9	-2.1	1.3	1.1
Locomotor activity	0.1	0.1	0.3	-0.1	0.0	0.6	-0.0	0.4	0.4
Locomotor testing distance	0.0	0.0	0.2	0.1	-0.0	0.5	0.0	0.1	0.1
Locomotor testing rearing	0.4	0.7	0.9	0.8	-0.9	-0.8	-0.9	0.9	0.8
Locomotion in novel chamber	0.2	0.2	0.8	0.0	0.0	-0.7	-0.0	-0.9	0.0
Locomotion in novel chamber post-restriction	0.6	1.1	2.5	-1.6	1.4	1.2	0.5	0.1	0.4
Fecal boli incidents, locomotor time 1	0.2	0.3	0.9	-0.3	0.3	-0.1	0.3	-0.9	-0.9
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.0	0.0	-0.4	0.2	-0.5	0.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.6	-0.2	0.3	0.4	0.4	-1.2	0.7
Bouts of movement, locomotor time 1	1.5	1.7	2.9	1.2	-1.2	-1.3	-1.7	0.2	1.5
Total resting periods, locomotor time 1	1.6	1.7	3.3	1.2	-1.2	-1.4	-1.6	-0.0	1.8
Rest time, locomotor task time 1	0.6	0.7	3.4	-0.4	0.3	0.1	-0.5	-0.6	1.8
Distance moved, locomotor task time 1	0.4	0.6	2.1	-0.2	0.2	0.7	0.7	1.5	-0.7
Vertical activity count, locomotor time 1	0.5	1.2	3.0	-0.9	0.9	1.7	1.3	0.7	-0.8
Time >=10cm from walls, locomotor time 2	3.3	4.9	6.8	-2.1	2.3	2.6	2.4	-1.9	-1.9
Bouts of movement, locomotor time 2	0.4	0.6	2.2	0.4	-0.5	-0.7	-0.5	0.4	1.5
Total resting periods, locomotor time 2	0.2	0.3	1.8	0.1	-0.1	-0.3	-0.2	0.2	1.3
Rest time, locomotor task time 2	1.4	1.8	2.6	-1.4	1.4	1.5	1.2	-1.6	0.7
Distance moved, locomotor task time 2	0.4	0.5	2.5	-0.1	0.0	0.7	-0.0	1.6	0.1
Vertical activity count, locomotor time 2	0.3	0.4	2.1	0.3	-0.3	0.6	-0.1	1.5	0.0
Light reinforcement 1	1.5	3.7	4.7	2.0	-2.0	-1.9	-2.0	1.4	2.2
Light reinforcement 2	2.5	3.9	5.4	2.3	-2.3	-1.7	-1.9	2.1	1.3
Bone: marrow area	0.5	1.0	1.5	1.2	-1.1	-1.1	-1.2	0.2	0.8
Bone: maximum diameter	1.9	3.5	5.0	2.2	-2.1	-1.8	-1.9	0.8	2.0
Bone: maximum force	0.2	0.4	1.9	-0.2	0.2	0.5	0.2	0.3	1.4
Bone: maximum moment	0.2	0.3	1.1	-0.4	0.4	0.6	0.4	-0.2	1.0
Mean time between licks in bursts	0.3	0.8	1.4	-1.0	1.0	1.2	0.2	-0.2	1.1
Mean num. licks in bursts	1.0	1.5	3.2	-1.3	1.4	1.8	0.6	-1.1	-0.9
Cd content in liver	1.0	1.1	2.5	0.6	-0.7	-0.2	-1.4	1.1	1.6
Co content in liver	0.3	0.4	1.3	-0.4	0.6	1.1	0.1	-0.6	-0.3
Cu content in liver	3.2	3.8	5.0	2.1	-2.2	-2.0	-2.2	2.0	0.8
Fe content in liver	0.6	0.7	1.2	1.1	-0.9	0.1	-0.8	0.8	-1.0
K content in liver	1.4	1.3	3.5	1.1	-1.2	-1.9	-0.8	1.0	-0.5
Mg content in liver	2.2	2.3	4.5	1.5	-1.6	-2.1	-1.7	1.0	0.7
Mn content in liver	0.1	0.1	0.4	-0.2	0.2	-0.1	-0.2	-0.6	0.5
Na content in liver	0.6	0.6	1.3	1.2	-1.0	-0.7	-0.2	0.0	-1.0
Rb content in liver	1.7	2.0	4.8	0.7	-0.8	-1.6	-2.2	1.9	0.3
Se content in liver	0.1	0.2	0.3	0.4	-0.4	-0.4	-0.5	0.6	-0.2
Sr content in liver	0.4	0.4	1.1	1.0	-0.9	-0.5	-0.2	-0.0	0.0
Zn content in liver	6.2	6.9	8.8	2.8	-2.9	-3.0	-2.6	2.7	1.5
Bone: minimum diameter	0.6	1.1	1.9	1.4	-1.3	-0.8	-1.2	0.8	0.9
Time in familiar zone, hab. session 1	0.3	0.3	0.8	-0.5	0.6	0.9	0.5	-0.3	0.4
Time in novel zone, hab. session 1	0.8	0.8	1.4	0.8	-0.9	-0.9	-1.2	0.9	0.5
Total zone transitions, hab. session 1	1.9	2.6	4.6	-1.1	1.3	1.5	2.2	-1.4	-1.9
Total locomotion distance, hab. session 1	0.6	0.8	2.5	1.0	-0.7	-0.5	0.5	-0.5	-1.6
Locomotion velocity, hab. session 1	0.8	1.1	3.5	1.2	-0.8	-0.7	0.6	-0.7	-1.9
Time in familiar zone, hab. session 2	4.3	4.5	6.4	2.1	-2.1	-1.9	-2.4	1.6	2.5
Time in novel zone, hab. session 2	3.4	3.4	7.3	-1.5	1.7	1.6	1.8	-1.5	-2.7
Total zone transitions, hab. session 2	0.1	0.2	0.6	-0.2	0.3	0.1	0.4	-0.8	-0.1
Total locomotion distance, hab. session 2	0.7	0.9	1.6	1.3	-1.1	-1.1	-0.7	-0.5	0.6
Locomotion velocity, hab. session 2	0.4	0.6	1.2	1.1	-0.9	-0.9	-0.3	-0.7	0.2
Novel to familiar place preference ratio	2.5	2.8	4.6	-1.6	1.6	2.0	2.1	-1.7	-0.3
Novelty place preference	2.9	3.1	5.1	-1.7	1.7	2.1	2.3	-1.8	-0.4
Time in novel zone, NPP test	2.7	2.8	4.9	-1.6	1.6	2.0	2.2	-1.7	-0.1
Total zone transitions, NPP test	0.1	0.1	0.4	0.3	-0.2	-0.3	0.0	-0.0	-0.6
Total locomotion distance, NPP test	1.1	1.5	2.7	1.6	-1.4	-1.4	-1.2	0.1	-0.9
Locomotion velocity, NPP test	1.2	1.7	3.1	1.8	-1.5	-1.5	-1.4	0.2	-0.9
Intraocular pressure	5.2	7.5	11.9	-3.4	3.4	3.3	2.5	-2.1	-0.2
Delta distance traveled before/after self-admin	5.0	5.3	9.2	2.8	-2.6	-3.0	-2.4	-0.2	1.4
Delta ambulatory time before/after self-admin	3.7	4.6	7.9	2.8	-2.6	-2.6	-2.3	-0.2	1.0
Parametrial fat weight	0.9	2.0	3.3	-1.3	1.3	0.8	1.4	-1.8	-1.6
Pavlov. Cond. lever latency	0.1	0.1	0.5	-0.4	0.3	0.7	0.1	0.1	0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.3	-0.4	-0.4	0.1	0.5	0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.5	-0.4	-0.0	0.0	0.3	-0.4
Pavlov. Cond. index score	0.1	0.1	0.1	0.3	-0.3	-0.4	0.3	0.1	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	0.2	-0.1	-0.3	0.5	-0.2	-0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.9	0.6	-0.5	-0.9	-0.1	0.1	-0.1
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	-0.3	0.3	0.2	-0.3	-0.5	-0.6
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.8	1.2	-1.0	-0.6	-1.3	0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	0.5	-0.4	-0.5	0.1	0.2	-0.0
Pavlov. Cond. response bias	0.2	0.2	0.3	0.5	-0.5	-0.6	0.0	0.5	0.4
Pavlov. Cond. lever latency	1.5	2.1	3.1	-1.8	1.7	1.7	1.3	-1.2	-0.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.3	0.6	-0.5	-0.4	-0.2	0.3	-0.4
Pavlov. Cond. change in total contacts	1.4	2.3	3.9	2.0	-1.9	-1.9	-0.5	1.6	-0.1
Pavlov. Cond. index score	0.9	1.1	2.0	1.4	-1.3	-1.3	-0.6	0.9	-0.3
Pavlov. Cond. latency score	0.8	1.0	1.6	1.2	-1.2	-1.3	-0.6	0.9	-0.5
Pavlov. Cond. lever contacts	1.6	2.2	3.6	1.9	-1.8	-1.8	-1.3	1.0	0.5
Pavlov. Cond. magazine entry number	0.9	1.1	2.0	-1.2	1.2	1.4	0.8	-1.2	-0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.5	-0.4	0.3	-0.7	0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	1.8	1.3	-1.3	-1.2	-0.5	1.0	-0.4
Pavlov. Cond. response bias	2.2	3.0	5.0	2.2	-2.2	-2.1	-1.4	1.3	0.6
Time in closed arm before self-admin	1.3	1.7	4.5	-1.4	1.5	2.1	0.4	-1.0	0.1
Time in closed arm after self-admin	0.9	0.9	1.7	-0.9	0.9	1.1	0.6	-0.9	-1.3
Time in open arm before self-admin	1.3	1.4	4.7	1.3	-1.3	-2.2	-0.3	-0.2	-0.2
Time in open arm after self-admin	0.5	0.5	1.7	-0.0	-0.1	-0.1	-0.0	1.2	1.3
Bone: periosteal estimation	0.8	1.8	3.7	1.4	-1.3	-1.0	-1.3	0.7	1.9
Bone: periosteal perimeter	0.5	0.8	2.2	0.8	-0.8	-0.8	-0.8	0.4	1.5
Bone: post-yield work	0.0	0.0	0.1	0.2	-0.2	-0.2	0.0	0.3	0.3
Progressive ratio test 1 active lever presses	0.3	0.4	1.3	0.0	0.0	-0.7	0.4	-1.1	-0.8
Progressive ratio test 1 breakpoint	0.3	0.4	1.3	0.0	0.0	-0.7	0.3	-1.1	-0.7
Progressive ratio test 1 inactive lever presses	0.2	0.3	1.1	0.3	-0.3	-1.0	0.4	-0.7	-0.4
Progressive ratio test 2 active lever presses	0.7	0.8	2.1	-0.2	0.3	-0.5	0.8	-1.5	-1.4
Progressive ratio test 2 breakpoint	0.7	0.8	2.2	-0.2	0.3	-0.5	0.7	-1.4	-1.5
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	-0.1	0.1	-0.6	0.5	-0.5	-0.6
Incentive Sensitization - Responses	0.1	0.2	0.6	-0.2	0.3	0.3	0.3	-0.4	-0.8
Incentive Sensitization - Breakpoint	0.2	0.2	0.8	-0.2	0.3	0.3	0.4	-0.5	-0.9
Sum of active levers in priming session hrs 5-6	5.2	4.9	8.9	3.0	-2.8	-2.1	-2.3	1.6	-0.4
Progressive ratio	0.3	0.4	0.9	0.7	-0.7	-1.0	-0.4	-0.3	-0.6
Food seeking constrained by brief footshock	0.2	0.2	0.4	0.4	-0.5	-0.5	-0.3	0.6	0.2
Seeking ratio, punishment vs. effort	0.4	0.5	1.5	-0.7	0.6	0.6	-0.0	0.8	1.2
Retroperitoneal fat weight	1.9	8.3	12.2	-3.5	3.4	3.0	3.0	-2.1	-2.0
Reaction time number correct	0.7	1.4	2.0	-1.2	1.3	1.4	1.0	-1.3	0.3
Reaction time mean minus median	0.1	0.2	0.4	0.6	-0.5	0.2	-0.3	0.2	0.3
Reaction time mean minus median AUC	0.1	0.2	0.5	0.5	-0.3	0.6	0.0	-0.7	-0.2
Reaction time num false alarms	0.5	0.8	1.8	-0.6	0.7	0.7	0.8	-1.3	-1.0
Reaction time num false alarms AUC	0.9	1.5	3.2	-1.0	1.0	0.9	1.2	-1.8	-1.2
Reaction time trials correct on left	0.7	1.4	2.0	-1.2	1.3	1.4	1.0	-1.3	0.3
Reaction time trials on left	0.7	1.4	2.1	-1.3	1.3	1.4	1.0	-1.3	0.3
Reaction time mean	0.5	0.8	1.3	-0.7	0.7	0.9	0.7	-1.2	-1.0
Reaction time mean AUC	0.3	0.4	1.1	-0.3	0.4	0.5	0.5	-1.1	-0.9
Median of all reaction times	1.0	1.5	2.7	-1.1	1.1	0.9	1.2	-1.6	-1.2
Reaction time omissions	0.1	0.2	0.8	-0.1	0.0	0.1	-0.9	0.2	0.3
Reaction time false alarm rate	0.4	0.6	2.1	-0.3	0.4	0.3	0.6	-0.9	-1.4
Reaction time premature initiation rate	2.2	3.0	4.2	1.7	-1.7	-1.3	-2.0	1.9	1.7
Reaction time premature initiations	1.0	1.7	3.1	1.3	-1.2	-0.9	-1.5	1.1	1.8
Std. dev. reaction times	0.3	0.5	1.6	-0.1	0.3	1.3	0.3	-0.7	-0.8
Reaction time trials completed	0.7	1.4	2.1	-1.3	1.3	1.4	1.0	-1.3	0.3
Reaction time trials AUC	0.7	1.4	2.2	-1.2	1.3	1.5	1.0	-1.3	0.4
Run reversals in cocaine runway, females	0.0	0.0	0.2	-0.1	0.1	-0.0	0.2	-0.0	0.4
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.7	0.5	0.0	0.5	0.3	-0.5
Latency to leave start box in cocaine runway	2.0	2.3	4.2	1.4	-1.5	-1.2	-1.8	1.0	2.1
Latency to leave start box in cocaine runway, F	1.3	1.5	2.6	1.0	-1.1	-0.9	-1.4	1.3	1.6
Latency to leave start box in cocaine runway, M	0.7	0.7	1.4	0.8	-0.8	-0.7	-0.7	-0.5	1.2
Std. dev. time between licks in bursts	0.1	0.1	0.4	-0.0	0.0	0.1	0.1	0.7	0.5
Total sessions with >9 infusions	2.4	2.9	5.6	-1.5	1.5	0.6	1.8	-1.9	-2.4
Short access day 1 total inactive lever presses	0.8	1.1	1.9	1.2	-1.1	-1.2	0.3	0.3	-1.4
Short access day 10 total inactive lever presses	0.2	0.6	1.3	0.7	-0.7	-0.3	-0.2	1.0	1.2
Short access day 1 total infusions	1.6	2.1	5.3	0.1	0.0	-1.1	1.7	-1.8	-2.3
Short access day 10 total infusions	0.2	0.2	0.5	0.2	-0.2	-0.6	-0.2	-0.5	-0.7
Short access total infusions	0.8	1.0	2.6	-0.0	0.0	-1.1	0.5	-1.3	-1.6
Short access day 1 locomotion	1.4	1.8	6.5	-0.6	0.8	0.3	1.2	-2.5	-1.3
Short access day 10 total locomotion	1.8	3.4	4.7	-2.2	2.1	1.6	1.8	-1.5	-1.8
Short access total locomotion	1.1	1.3	3.1	-0.9	0.9	0.2	1.0	-1.5	-1.8
One hour access (0.3 mA shock)	0.2	0.3	1.3	-0.1	0.1	-0.5	-0.2	-1.1	-0.2
Compulsive drug intake	1.3	1.6	2.1	-1.0	1.0	1.5	1.4	-1.3	-1.3
One hour access (shock baseline)	0.3	0.5	1.9	0.4	-0.5	-1.4	-0.8	-0.2	-0.1
Social response proportion	1.1	1.2	2.5	-1.3	1.2	0.6	1.6	-1.0	-0.6
Social responses	1.0	1.3	2.9	1.2	-1.2	-1.7	0.4	0.0	-1.2
Social time	0.4	0.5	1.0	-1.0	0.7	-0.5	0.8	-0.7	-0.3
Soleus weight	2.0	6.0	11.8	-3.4	3.2	2.1	2.3	-1.7	-1.1
Bone: stiffness	0.4	0.7	2.6	0.2	-0.3	0.0	-0.3	1.1	1.6
Tibialis anterior weight	1.5	4.9	8.7	-2.9	2.8	2.6	1.5	-1.5	1.3
Time to tail flick, vehicle, before self-admin	0.9	1.0	1.8	1.2	-1.2	-0.6	-0.6	1.3	0.6
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.5	0.4	-0.4	-0.2	0.0	0.4	-1.2
Time to tail flick, test, before self-admin	0.2	0.2	0.5	-0.3	0.4	0.7	0.3	-0.5	-0.4
Time to tail flick, test, after self-admin	0.4	0.4	1.2	0.6	-0.6	-1.1	-0.5	0.0	-0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.8	0.7	-0.0	-0.1	-0.5	-0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	-0.1	-0.1	-0.9	0.4	-0.0	-0.4
Tibia length	0.7	2.1	4.6	-1.5	1.6	2.2	1.5	-0.6	0.6
Ambulatory time before self-admin	0.2	0.3	0.6	0.2	-0.2	0.6	0.7	0.4	-0.8
Ambulatory time after self-admin	1.8	2.1	5.1	2.3	-2.0	-1.5	-1.2	-0.1	-0.1
Bone: tissue strength	0.1	0.1	0.3	-0.2	0.3	0.5	0.2	-0.1	0.6
Total heroin consumption	0.9	1.1	5.0	0.0	0.0	-0.1	1.0	-0.7	-2.2
Bone: trabecular number	0.1	0.2	0.3	0.5	-0.3	0.3	-0.6	0.5	0.2
Bone: trabecular spacing	0.3	0.5	2.2	-0.4	0.2	-0.3	-0.5	0.3	1.5
Bone: trabecular thickness	0.3	0.4	1.3	0.2	-0.2	0.0	0.1	1.1	-0.9
Bone: trabecular tissue density	0.7	1.0	1.8	-1.3	1.2	1.1	0.3	-0.2	1.3
Water consumed over 24 hours	0.5	0.6	1.2	0.7	-0.5	0.8	-1.0	1.1	0.1
Number of responses in last shaping day	1.3	1.4	4.0	1.3	-1.3	-2.0	-0.7	0.3	0.4