Hub : Genes

Srp19

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Srp19	0.02	0.02	8.2e-03	0	0.01	0	0	3.3e-01	4.3e-02	1.3e-01	1.6e-01
2	Adipose	gene expression	Srp19	0.05	0.04	1.9e-04	0.03	0.02	0.02	0.03	3.0e-04	2.3e-03	4.2e-03	4.5e-04
3	RMTg	gene expression	Srp19	0.09	0.06	6.2e-03	0.06	0.06	0.06	0.06	1.2e-02	1.3e-02	1.0e-02	1.3e-02
4	Eye	intron excision ratio	chr18_25935986_25936079	0.23	0.14	9.6e-03	0.1	0.05	0.03	0.03	1.5e-02	7.0e-02	1.2e-01	1.0e-01
5	Liver	intron excision ratio	chr18_25931783_25935915	0.03	0.02	1.8e-04	0.03	0.03	0.03	0.03	4.2e-04	8.4e-04	7.8e-04	6.7e-04
6	Liver	gene expression	Srp19	0.05	0.04	5.8e-04	0.02	0.01	0.01	0.01	3.2e-03	8.9e-03	3.4e-02	9.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	1.0	1.0	0.3	0.7	0.4	-0.4	0.4
Area under the delay curve	3.9	4.1	4.7	1.8	2.2	1.8	2.1	-2.1	2.2
BMI with tail	7.3	23.6	32.5	-5.7	-5.2	-5.0	-4.3	4.3	-4.4
BMI without tail	5.5	11.4	15.9	-4.0	-3.6	-3.6	-3.1	3.1	-2.9
Body weight	7.5	31.5	36.6	-6.0	-6.0	-5.6	-5.2	5.2	-5.5
Weight adjusted by age	1.8	2.1	2.9	-1.6	-1.2	-1.2	-1.4	1.4	-1.7
Bone surface	0.8	1.4	2.1	1.4	0.6	1.1	1.2	-1.2	1.3
Bone volume	0.5	0.8	1.4	1.2	0.3	0.8	0.9	-0.9	0.8
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.0	-0.1	-0.2	-0.5	0.5	-0.3
Number of licking bursts	0.9	1.1	1.7	1.3	0.8	1.2	1.0	-1.0	0.8
Context. condit. distance diff. score	0.0	0.0	0.1	-0.2	-0.0	-0.2	0.1	-0.1	0.1
Locomotion velocity, session 1	0.2	0.2	0.7	-0.2	-0.8	-0.6	-0.3	0.3	-0.4
Locomotion distance, session 1	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.2	0.2	-0.2
Locomotion velocity, session 2	0.5	0.5	1.0	-0.9	-1.0	-0.8	-0.6	0.6	-0.4
Locomotion distance, session 2	0.5	0.6	0.8	0.9	0.7	0.8	0.9	-0.9	0.6
Locomotion velocity, session 3	0.3	0.3	0.6	-0.7	-0.7	-0.8	-0.1	0.1	-0.3
Locomotion distance, session 3	0.0	0.0	0.0	0.2	0.2	-0.0	0.0	-0.0	-0.1
Stereotopy head waving bouts, day 3	3.5	4.1	5.3	1.7	1.7	1.8	2.3	-2.3	2.3
Stereotopy head waving duration, day 3	0.7	0.8	1.7	0.2	0.6	0.5	1.1	-1.1	1.3
Locomotion velocity, session 7	0.2	0.2	0.5	-0.5	-0.7	-0.5	-0.4	0.4	-0.3
Locomotion distance, session 7	0.1	0.1	0.2	0.5	0.2	0.3	0.3	-0.3	0.2
Stereotopy head waving bouts, day 7	0.3	0.3	0.6	-0.8	-0.4	-0.4	-0.6	0.6	-0.6
Stereotopy head waving duration, day 7	0.1	0.1	0.3	-0.5	-0.0	-0.0	-0.2	0.2	-0.1
Locomotion velocity, session 8	0.2	0.2	0.6	-0.8	-0.3	-0.5	0.2	-0.2	0.4
Locomotion distance, session 8	0.0	0.1	0.1	-0.0	0.1	-0.1	0.4	-0.4	0.2
Degree of sensitization distance	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.2	0.2	-0.2
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.6	-0.1	-0.1	-0.6	0.6	-0.6
Conditioned locomotion	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.2	-0.2	-0.1
Cocaine response after cond. corrected	1.0	1.1	1.7	-0.9	-1.0	-1.3	-1.0	1.0	-1.1
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.1	-0.1	-0.5	-0.4	0.4	-0.5
Cocaine response before conditioning	4.3	5.2	6.5	2.4	2.5	2.6	2.1	-2.1	2.1
Saline control response	0.5	0.6	1.5	1.0	1.2	1.0	-0.3	0.3	-0.2
Bone: connectivity density	1.8	2.8	3.6	1.9	1.3	1.7	1.7	-1.7	1.8
Bone: cortical apparent density	1.2	1.6	2.3	1.3	1.5	1.5	1.0	-1.0	1.2
Bone: cortical area	2.2	3.4	5.3	2.3	1.8	2.0	1.6	-1.6	1.5
Bone: cortical porosity	0.7	0.7	1.0	-0.8	-0.9	-1.0	-0.7	0.7	-1.0
Bone: cortical porosity	0.5	0.6	0.8	-0.7	-0.8	-0.9	-0.6	0.6	-0.9
Bone: cortical thickness	1.8	3.0	3.8	1.9	1.7	1.9	1.6	-1.6	1.5
Bone: cortical thickness	0.1	0.2	0.3	0.6	0.4	0.5	0.2	-0.2	0.3
Bone: cortical tissue density	1.0	1.3	2.0	1.2	1.4	1.3	0.9	-0.9	1.0
Condit. Reinf. active minus inactive responses	3.2	3.6	4.6	1.8	1.7	1.7	2.1	-2.1	1.9
Condit. Reinf. active-inactive response ratio	1.4	1.5	1.8	1.1	1.3	1.2	1.3	-1.3	1.2
Condit. Reinf. active responses	2.6	3.2	4.2	2.1	1.5	1.6	2.0	-2.0	1.6
Condit. Reinf. inactive responses	1.3	1.5	3.1	1.8	0.9	1.0	1.3	-1.3	0.9
Incentive salience index mean	2.3	2.8	3.3	1.8	1.7	1.7	1.7	-1.7	1.5
Condit. Reinf. lever presses	1.0	1.3	2.4	1.6	1.5	1.4	0.7	-0.7	0.6
Condit. Reinf. active minus inactive responses	3.1	3.8	6.1	2.5	2.3	1.9	1.6	-1.6	1.6
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	0.2	-0.2	-0.1	0.1	-0.2
Condit. Reinf. active responses	7.6	10.5	14.8	3.8	3.7	3.3	2.8	-2.8	2.8
Condit. Reinf. inactive responses	8.2	10.0	12.6	3.6	3.5	3.4	2.8	-2.8	2.9
Condit. Reinf. lever presses	1.8	2.4	4.7	2.2	1.7	1.6	1.3	-1.3	1.1
Condit. Reinf. lever reinforcers received	7.1	10.0	13.5	3.7	3.7	3.2	2.8	-2.8	2.8
Conditioned reinforcement - actives	0.1	0.1	0.2	0.1	-0.0	-0.3	-0.4	0.4	-0.3
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.3	0.2	0.1	-0.2	0.2	0.3
Conditioned locomotion	0.1	0.1	0.3	0.6	0.2	0.2	0.1	-0.1	0.0
Patch foraging indifference point 0 sec	1.6	2.6	4.0	1.8	2.0	1.8	1.2	-1.2	1.5
Patch foraging indifference point AUC	3.7	4.2	5.5	2.3	2.1	2.2	1.8	-1.8	2.0
Delay disc. indifference point, 0s delay	1.0	1.1	1.7	1.1	1.3	1.0	0.9	-0.9	1.1
Delay disc. indifference point, 16s delay	5.3	5.3	5.9	2.1	2.3	2.2	2.4	-2.4	2.4
Delay disc. indifference point, 2s delay	0.5	0.5	0.9	0.7	0.8	0.6	0.7	-0.7	0.9
Delay disc. indifference point, 24s delay	0.8	0.8	1.2	0.5	0.7	0.5	1.1	-1.1	1.1
Delay disc. indifference point, 4s delay	0.6	0.7	0.8	0.9	0.9	0.7	0.8	-0.8	0.9
Delay disc. indifference point, 8s delay	5.2	5.4	6.2	2.0	2.5	2.0	2.5	-2.5	2.4
Indifference point function ln k	10.0	14.0	14.9	-3.9	-3.6	-3.7	-3.7	3.7	-3.8
Indifference point function log k	10.0	14.0	14.9	-3.9	-3.6	-3.7	-3.7	3.7	-3.8
Patch foraging total patch changes 0 sec	1.7	2.7	3.8	1.9	2.0	1.8	1.3	-1.3	1.6
Patch foraging total patch changes 12 sec	9.8	12.7	14.5	3.8	3.7	3.7	3.3	-3.3	3.5
Patch foraging total patch changes 18 sec	4.8	6.2	8.5	2.9	2.3	2.4	2.4	-2.4	2.4
Patch foraging total patch changes 24 sec	2.9	3.6	4.3	2.1	2.0	2.0	1.7	-1.7	1.8
Patch foraging total patch changes 6 sec	3.3	4.8	7.2	2.7	2.5	2.3	1.7	-1.7	2.1
Patch foraging time to switch 0 sec	0.1	0.1	0.3	-0.5	-0.3	-0.5	-0.1	0.1	-0.1
Patch foraging water rate 0 sec	0.0	0.0	0.1	-0.0	-0.1	-0.0	-0.1	0.1	-0.3
Patch foraging water rate 12 sec	0.9	1.4	2.6	-0.9	-1.2	-1.1	-1.0	1.0	-1.6
Patch foraging water rate 18 sec	0.4	0.5	0.8	-0.4	-0.4	-0.7	-0.8	0.8	-0.9
Patch foraging water rate 24 sec	0.2	0.3	0.5	-0.4	-0.5	-0.7	-0.4	0.4	-0.6
Patch foraging water rate 6 sec	0.1	0.1	0.3	-0.2	-0.5	-0.5	-0.2	0.2	-0.5
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.2	1.1	1.0	1.0	0.1	-0.1	0.3
Distance traveled before self-admin	0.2	0.2	0.5	0.3	0.4	0.2	0.7	-0.7	0.3
Distance traveled after self-admin	0.4	0.5	1.4	1.2	1.1	0.3	0.2	-0.2	0.4
Extensor digitorum longus weight	2.4	9.6	10.8	-3.3	-2.9	-3.0	-3.2	3.2	-3.2
Bone: elastic displacement	1.2	1.4	2.1	-1.4	-1.0	-1.3	-1.2	1.2	-0.9
Bone: elastic work	2.3	3.0	4.0	-1.8	-1.3	-1.5	-2.0	2.0	-1.6
Bone: endosteal estimation	0.5	1.2	1.6	1.2	0.7	0.8	1.2	-1.2	1.3
Bone: endosteal perimeter	0.1	0.2	0.4	0.5	0.3	0.2	0.7	-0.7	0.5
Epididymis fat weight	4.4	10.2	12.9	-3.6	-3.1	-3.3	-3.1	3.1	-3.0
Delta time in closed arm before/after self-admin	2.4	2.3	3.4	-1.8	-1.5	-1.6	-1.5	1.5	-1.3
Delta time in open arm before/after self-admin	1.1	1.1	1.5	1.0	0.6	1.2	1.1	-1.1	1.0
Diff in mean of infusions in LGA sessions	1.6	1.7	2.8	-0.9	-1.1	-1.4	-1.3	1.3	-1.7
Delay discount exponential model param	4.1	4.3	4.9	-1.9	-2.2	-1.9	-2.1	2.1	-2.2
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.0	-0.2	-0.2	0.1	-0.1	-0.3
Active lever presses in extinction session 6	1.7	1.7	2.8	1.7	1.3	1.3	1.3	-1.3	0.9
Bone: final force	1.2	1.9	2.4	1.6	1.3	1.4	1.3	-1.3	1.5
Bone: final moment	0.6	1.0	1.5	1.2	0.9	1.0	0.9	-0.9	1.1
Food consumed during 24 hour testing period	1.4	1.7	2.7	-1.0	-1.6	-1.3	-1.3	1.3	-1.2
Glucose	8.9	13.4	14.5	-3.4	-3.5	-3.7	-3.8	3.8	-3.7
Heart weight	3.8	5.4	6.4	-2.2	-2.5	-2.2	-2.3	2.3	-2.5
Delay discount hyperbolic model param	3.6	3.8	4.3	-1.9	-2.0	-1.8	-2.0	2.0	-2.1
Intermittent access intake day 1-15 change	0.3	0.3	0.5	-0.7	-0.7	-0.4	-0.2	0.2	-0.5
Intermittent access intake escalation	0.1	0.1	0.2	-0.4	-0.5	-0.2	-0.0	0.0	-0.2
Intermittent access intake escalation 2	0.3	0.3	0.5	-0.5	-0.7	-0.4	-0.4	0.4	-0.5
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.2	0.0	0.2	-0.1	0.1	-0.0
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.3	-0.2	-0.4	-0.4	-0.6	0.6	-0.5
Intermitt. access escalation Index	1.0	0.9	1.1	-0.9	-1.0	-0.9	-0.9	0.9	-1.0
Intermittent access day 1 total infusions	0.1	0.2	0.4	0.6	0.6	0.3	0.1	-0.1	0.2
Intermittent access day 15 total infusions	0.0	0.0	0.1	0.3	0.3	0.1	0.1	-0.1	0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.1	0.2	0.1	-0.1	0.1	-0.0
Intermittent access total infusions	0.1	0.1	0.2	0.0	0.1	-0.2	-0.4	0.4	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.3
Intermittent access day 15 total locomotion	3.2	3.4	4.4	-1.5	-1.7	-1.7	-2.1	2.1	-2.0
Intermittent access total locomotion	1.6	1.9	2.6	-1.0	-1.1	-1.2	-1.6	1.6	-1.5
Intermittent access standard deviation	0.0	0.0	0.1	-0.2	-0.1	0.1	0.2	-0.2	0.3
Left kidney weight	0.3	0.8	1.3	-0.5	-1.0	-0.7	-1.0	1.0	-1.1
Right kidney weight	0.4	1.0	1.6	-0.5	-0.9	-0.6	-1.3	1.3	-1.2
Cocaine induced anxiety	0.0	0.1	0.2	0.0	-0.5	-0.3	0.1	-0.1	0.0
Post-drug Anxiety	0.3	0.3	0.8	0.9	0.2	0.7	0.4	-0.4	0.3
Baseline Anxiety	0.3	0.3	0.8	0.5	0.6	0.9	0.3	-0.3	0.2
Tail length	0.1	0.4	0.5	-0.7	-0.6	-0.7	-0.7	0.7	-0.6
Length with tail	0.9	3.5	4.2	-1.6	-1.9	-1.7	-1.9	1.9	-2.1
Length without tail	0.8	1.7	2.7	-1.2	-1.4	-1.0	-1.3	1.3	-1.6
Times rat made contact with spout	0.4	0.5	0.7	-0.2	-0.5	-0.7	-0.8	0.8	-0.8
Lifetime Intake	0.1	0.1	0.2	-0.1	0.1	-0.4	-0.5	0.5	-0.3
Liver weight, left	0.1	0.2	0.5	0.4	-0.1	-0.0	-0.7	0.7	-0.4
Liver weight, right	1.2	2.0	2.4	1.2	1.3	1.3	1.5	-1.5	1.5
Locomotor activity	0.1	0.2	0.4	0.0	0.2	0.3	0.6	-0.6	0.4
Locomotor testing distance	0.0	0.0	0.0	0.1	0.1	0.1	0.2	-0.2	-0.1
Locomotor testing rearing	0.4	0.6	0.9	0.9	0.9	0.8	0.7	-0.7	0.5
Locomotion in novel chamber	0.2	0.2	0.4	-0.3	0.2	-0.2	0.6	-0.6	0.5
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.5	-0.5	-0.0	0.1	-0.1	-0.1
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	-0.3	0.0	-0.4	-0.6	0.6	-0.0
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.2	-0.1	-0.3	-0.1	0.1	0.2
Time >=10cm from walls, locomotor time 1	0.5	0.6	0.9	-0.7	-0.3	-0.7	-0.9	0.9	-0.7
Bouts of movement, locomotor time 1	1.1	1.2	2.2	0.9	1.5	1.1	1.0	-1.0	0.9
Total resting periods, locomotor time 1	0.9	1.0	1.9	0.8	1.4	1.0	0.9	-0.9	0.9
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.5	-0.2	-0.3	-0.4	0.4	-0.4
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.5	-0.2	0.5	0.1	-0.1	0.1
Vertical activity count, locomotor time 1	0.3	0.3	0.6	-0.2	-0.8	-0.1	-0.7	0.7	-0.6
Time >=10cm from walls, locomotor time 2	5.3	5.6	6.9	-2.1	-2.4	-2.1	-2.5	2.5	-2.6
Bouts of movement, locomotor time 2	0.3	0.3	0.5	0.4	0.3	0.5	0.7	-0.7	0.6
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.1	0.1	0.3	0.4	-0.4	0.3
Rest time, locomotor task time 2	1.5	1.8	2.5	-1.6	-1.2	-1.5	-1.2	1.2	-1.2
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.7	-0.1	0.7	0.2	-0.2	0.2
Vertical activity count, locomotor time 2	0.3	0.3	0.8	0.9	0.2	0.9	0.3	-0.3	0.2
Light reinforcement 1	1.4	2.6	3.2	1.7	1.8	1.5	1.5	-1.5	1.7
Light reinforcement 2	4.1	5.5	7.3	2.2	2.4	2.2	2.3	-2.3	2.7
Bone: marrow area	0.6	1.2	1.8	1.1	0.7	0.8	1.2	-1.2	1.3
Bone: maximum diameter	2.2	4.1	6.1	2.5	1.9	2.0	2.0	-2.0	1.8
Bone: maximum force	0.3	0.4	0.9	1.0	0.7	0.8	0.3	-0.3	0.6
Bone: maximum moment	0.1	0.1	0.3	0.6	0.3	0.4	-0.1	0.1	0.1
Mean time between licks in bursts	0.3	0.4	1.3	-0.6	-1.2	-0.8	-0.1	0.1	-0.1
Mean num. licks in bursts	1.9	2.2	2.9	-1.5	-1.3	-1.7	-1.5	1.5	-1.4
Cd content in liver	0.1	0.1	0.3	0.2	0.2	0.1	0.5	-0.5	0.3
Co content in liver	0.1	0.1	0.4	-0.1	-0.7	-0.2	0.0	-0.0	0.0
Cu content in liver	4.2	5.1	5.8	2.4	2.4	2.3	2.2	-2.2	2.0
Fe content in liver	1.7	2.0	2.6	1.6	1.2	1.4	1.5	-1.5	1.3
K content in liver	0.3	0.3	0.5	0.7	0.6	0.7	0.3	-0.3	0.5
Mg content in liver	1.4	1.5	1.8	1.4	1.3	1.3	1.0	-1.0	1.2
Mn content in liver	0.6	0.7	1.0	-0.7	-0.8	-0.7	-0.8	0.8	-1.0
Na content in liver	0.1	0.1	0.3	0.6	0.4	0.4	0.2	-0.2	-0.0
Rb content in liver	1.6	2.0	2.5	1.6	1.1	1.6	1.4	-1.4	1.4
Se content in liver	0.6	0.8	1.1	0.7	0.5	0.9	1.0	-1.0	1.0
Sr content in liver	1.4	1.3	1.6	1.0	1.1	0.9	1.3	-1.3	1.2
Zn content in liver	3.0	3.3	3.6	1.8	1.9	1.8	1.8	-1.8	1.9
Bone: minimum diameter	0.5	0.9	2.4	1.6	1.0	1.0	0.6	-0.6	0.5
Time in familiar zone, hab. session 1	0.4	0.3	0.8	-0.3	-0.7	-0.4	-0.5	0.5	-0.9
Time in novel zone, hab. session 1	1.3	1.3	2.2	0.8	1.2	0.9	1.1	-1.1	1.5
Total zone transitions, hab. session 1	1.9	2.7	3.4	-1.2	-1.8	-1.6	-1.7	1.7	-1.7
Total locomotion distance, hab. session 1	0.0	0.0	0.2	0.5	0.1	0.0	0.0	-0.0	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.2	0.5	0.1	-0.0	0.1	-0.1	0.0
Time in familiar zone, hab. session 2	3.3	3.4	4.6	1.6	1.7	1.8	2.1	-2.1	1.7
Time in novel zone, hab. session 2	2.3	2.3	2.8	-1.4	-1.4	-1.6	-1.7	1.7	-1.4
Total zone transitions, hab. session 2	0.3	0.4	0.7	-0.4	-0.4	-0.5	-0.7	0.7	-0.9
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.7	0.5	0.4	0.6	-0.6	0.2
Locomotion velocity, hab. session 2	0.0	0.1	0.2	0.4	0.2	0.0	0.3	-0.3	-0.1
Novel to familiar place preference ratio	1.9	2.0	2.6	-1.6	-0.9	-1.4	-1.6	1.6	-1.3
Novelty place preference	2.2	2.3	3.2	-1.8	-1.0	-1.4	-1.7	1.7	-1.4
Time in novel zone, NPP test	2.0	2.0	2.9	-1.7	-0.9	-1.4	-1.6	1.6	-1.3
Total zone transitions, NPP test	0.1	0.1	0.3	0.4	-0.2	-0.1	-0.4	0.4	-0.5
Total locomotion distance, NPP test	0.4	0.6	1.6	1.3	0.7	0.7	0.6	-0.6	0.5
Locomotion velocity, NPP test	0.5	0.7	2.0	1.4	0.8	0.8	0.6	-0.6	0.5
Intraocular pressure	4.7	6.6	8.8	-3.0	-2.9	-2.8	-2.3	2.3	-2.1
Delta distance traveled before/after self-admin	1.0	1.0	2.4	1.6	1.3	0.6	0.6	-0.6	1.1
Delta ambulatory time before/after self-admin	1.0	1.1	2.8	1.7	1.3	0.6	0.6	-0.6	1.1
Parametrial fat weight	0.7	1.3	2.2	-1.5	-0.9	-1.4	-1.1	1.1	-0.9
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.2	0.2	-0.2	0.3	-0.3	0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.7	0.5	0.6	0.8	0.2	-0.2	0.2
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.5	0.3	0.5	0.4	-0.4	0.3
Pavlov. Cond. index score	0.0	0.0	0.2	0.3	0.1	0.4	-0.0	0.0	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	-0.0	0.2	-0.2	0.2	-0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.6	0.4	0.7	0.1	-0.1	0.1
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	-0.5	-0.4	-0.7	-0.6	0.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.9	1.0	0.2	0.3	0.2	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.5	0.3	0.6	0.2	-0.2	0.1
Pavlov. Cond. response bias	0.2	0.2	0.5	0.6	0.4	0.7	0.3	-0.3	0.2
Pavlov. Cond. lever latency	1.0	1.4	2.6	-1.6	-1.4	-1.1	-0.9	0.9	-0.9
Pavlov. Cond. magazine entry latency	0.3	0.3	0.5	0.5	0.3	0.3	0.7	-0.7	0.6
Pavlov. Cond. change in total contacts	2.0	2.8	3.6	1.9	1.9	1.6	1.5	-1.5	1.6
Pavlov. Cond. index score	0.9	1.2	1.5	1.2	1.1	1.0	1.1	-1.1	1.0
Pavlov. Cond. latency score	0.9	1.1	1.4	1.2	1.0	1.0	1.0	-1.0	0.9
Pavlov. Cond. lever contacts	0.9	1.3	2.5	1.6	1.3	1.1	0.9	-0.9	0.9
Pavlov. Cond. magazine entry number	1.6	2.0	2.3	-1.3	-1.3	-1.3	-1.5	1.5	-1.5
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.2	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.3	1.6	1.3	1.1	1.0	1.2	-1.2	1.1
Pavlov. Cond. response bias	2.0	2.8	4.0	2.0	1.8	1.5	1.6	-1.6	1.5
Time in closed arm before self-admin	0.9	1.0	1.3	-0.8	-1.1	-0.9	-1.0	1.0	-1.1
Time in closed arm after self-admin	2.0	2.0	3.0	-1.2	-1.2	-1.2	-1.7	1.7	-1.3
Time in open arm before self-admin	0.1	0.1	0.3	-0.1	0.6	-0.0	0.5	-0.5	0.3
Time in open arm after self-admin	0.4	0.4	0.6	0.8	0.2	0.8	0.8	-0.8	0.4
Bone: periosteal estimation	1.2	2.5	3.5	1.9	1.4	1.5	1.6	-1.6	1.5
Bone: periosteal perimeter	0.5	0.9	1.4	1.2	1.0	0.9	0.9	-0.9	0.7
Bone: post-yield work	0.1	0.1	0.3	0.6	0.5	0.5	-0.0	0.0	0.1
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	-0.0	-0.1	-0.5	-0.6	0.6	-0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.1	-0.1	-0.5	-0.6	0.6	-0.4
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	0.4	0.6	0.2	0.2	-0.2	0.5
Progressive ratio test 2 active lever presses	0.5	0.5	0.8	-0.2	-0.3	-0.8	-0.9	0.9	-0.8
Progressive ratio test 2 breakpoint	0.6	0.7	1.0	-0.3	-0.5	-0.9	-1.0	1.0	-0.9
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.5	0.0	-0.3	-0.4	-0.7	0.7	-0.5
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.0	-0.4	-0.4	-0.4	0.4	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.0	-0.4	-0.5	-0.4	0.4	-0.4
Sum of active levers in priming session hrs 5-6	3.7	3.6	4.6	1.8	2.1	1.5	2.1	-2.1	1.7
Progressive ratio	0.0	0.0	0.1	-0.2	0.3	-0.2	0.2	-0.2	0.1
Food seeking constrained by brief footshock	0.3	0.3	0.5	0.2	0.5	0.5	0.7	-0.7	0.5
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	0.2	-0.0	0.4	0.2	-0.2	0.2
Retroperitoneal fat weight	3.7	12.0	15.6	-4.0	-3.5	-3.7	-3.1	3.1	-3.3
Reaction time number correct	1.4	2.1	3.1	-1.3	-1.7	-1.6	-1.4	1.4	-1.1
Reaction time mean minus median	0.5	0.6	1.3	0.3	0.5	0.3	1.1	-1.1	0.8
Reaction time mean minus median AUC	0.2	0.2	0.5	-0.2	-0.1	-0.3	0.7	-0.7	0.2
Reaction time num false alarms	0.6	0.9	1.5	-1.2	-0.9	-1.2	-0.8	0.8	-0.7
Reaction time num false alarms AUC	1.2	1.6	2.5	-1.5	-1.2	-1.6	-1.1	1.1	-1.0
Reaction time trials correct on left	1.4	2.1	3.1	-1.3	-1.7	-1.6	-1.4	1.4	-1.1
Reaction time trials on left	1.5	2.1	3.1	-1.4	-1.8	-1.7	-1.3	1.3	-1.1
Reaction time mean	0.3	0.4	1.0	-1.0	-0.7	-0.8	0.1	-0.1	-0.4
Reaction time mean AUC	0.2	0.3	0.6	-0.8	-0.4	-0.6	0.5	-0.5	-0.0
Median of all reaction times	0.7	0.9	2.0	-1.4	-1.1	-1.2	-0.4	0.4	-0.8
Reaction time omissions	0.3	0.4	1.2	-0.1	0.0	0.1	1.1	-1.1	0.6
Reaction time false alarm rate	0.2	0.3	0.5	-0.7	-0.3	-0.6	-0.4	0.4	-0.4
Reaction time premature initiation rate	2.1	2.8	5.5	2.3	1.3	2.0	1.5	-1.5	1.0
Reaction time premature initiations	0.7	1.0	2.6	1.6	0.5	1.2	0.8	-0.8	0.5
Std. dev. reaction times	0.2	0.3	0.5	-0.6	-0.7	-0.7	0.6	-0.6	-0.1
Reaction time trials completed	1.5	2.1	3.1	-1.4	-1.8	-1.7	-1.3	1.3	-1.1
Reaction time trials AUC	1.5	2.1	3.1	-1.4	-1.8	-1.7	-1.4	1.4	-1.1
Run reversals in cocaine runway, females	0.7	0.7	0.9	0.5	0.9	0.8	0.9	-0.9	0.9
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.2	0.3	0.3	0.4	-0.4	0.4
Latency to leave start box in cocaine runway	1.1	1.2	1.7	1.3	1.1	1.1	1.0	-1.0	1.1
Latency to leave start box in cocaine runway, F	0.6	0.7	1.3	1.1	0.6	1.0	0.7	-0.7	0.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.2	-0.1	0.4	-0.2	-0.1	0.1	0.0
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.3	0.1	0.2	0.3	-0.3	0.4
Total sessions with >9 infusions	0.9	1.0	1.2	-1.0	-0.8	-1.1	-1.1	1.1	-1.0
Short access day 1 total inactive lever presses	0.4	0.4	1.4	1.2	0.6	0.4	0.4	-0.4	0.4
Short access day 10 total inactive lever presses	0.1	0.2	0.5	0.7	0.1	0.5	0.2	-0.2	0.3
Short access day 1 total infusions	0.1	0.1	0.3	-0.3	0.4	-0.5	-0.3	0.3	-0.1
Short access day 10 total infusions	0.0	0.0	0.1	0.3	0.2	0.0	-0.1	0.1	-0.1
Short access total infusions	0.0	0.1	0.3	0.1	0.6	-0.0	0.0	-0.0	0.1
Short access day 1 locomotion	1.6	1.7	2.7	-1.1	-1.1	-1.6	-1.2	1.2	-1.3
Short access day 10 total locomotion	2.2	2.4	2.6	-1.6	-1.6	-1.4	-1.6	1.6	-1.5
Short access total locomotion	1.0	1.0	1.1	-1.1	-0.8	-1.0	-1.0	1.0	-1.0
One hour access (0.3 mA shock)	0.5	0.6	1.0	-0.7	-0.4	-0.9	-1.0	1.0	-0.7
Compulsive drug intake	0.7	0.7	1.1	-1.1	-0.6	-0.9	-0.7	0.7	-0.8
One hour access (shock baseline)	0.0	0.0	0.0	0.2	0.1	-0.0	-0.0	0.0	0.1
Social response proportion	0.9	0.9	2.1	-1.4	-1.0	-1.1	-0.7	0.7	-0.7
Social responses	0.7	1.0	1.5	0.9	1.2	0.9	0.9	-0.9	1.0
Social time	0.2	0.3	1.1	-1.0	-0.1	-0.4	-0.3	0.3	-0.7
Soleus weight	1.7	4.8	6.8	-2.6	-1.8	-2.0	-2.3	2.3	-2.1
Bone: stiffness	0.7	1.0	1.6	1.3	0.9	1.1	0.9	-0.9	0.9
Tibialis anterior weight	1.2	4.0	5.3	-2.3	-2.2	-1.9	-1.7	1.7	-2.1
Time to tail flick, vehicle, before self-admin	3.0	3.1	3.5	1.6	1.7	1.7	1.8	-1.8	1.9
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.6	0.4	0.4	0.5	0.7	-0.7	0.7
Time to tail flick, test, before self-admin	0.4	0.3	0.7	-0.1	-0.2	-0.3	-0.8	0.8	-0.7
Time to tail flick, test, after self-admin	0.7	0.7	2.2	0.9	1.5	1.0	0.2	-0.2	0.6
Delta time to tail flick, vehicle, before/after SA	0.8	0.7	1.0	-0.8	-0.9	-0.8	-0.8	0.8	-1.0
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	0.0	0.7	0.4	0.3	-0.3	0.4
Tibia length	0.8	2.2	3.8	-1.7	-1.9	-1.7	-0.9	0.9	-1.4
Ambulatory time before self-admin	0.1	0.1	0.1	0.1	0.2	0.2	0.4	-0.4	0.0
Ambulatory time after self-admin	0.3	0.4	1.1	1.0	0.9	0.3	0.2	-0.2	0.3
Bone: tissue strength	0.0	0.0	0.1	-0.1	-0.2	-0.3	-0.0	0.0	-0.0
Total heroin consumption	0.2	0.2	0.3	-0.4	-0.2	-0.4	0.5	-0.5	0.6
Bone: trabecular number	0.1	0.2	0.5	0.7	0.1	0.5	0.2	-0.2	0.2
Bone: trabecular spacing	0.1	0.1	0.3	-0.2	0.2	0.2	0.5	-0.5	0.1
Bone: trabecular thickness	0.1	0.2	0.5	0.7	0.2	0.6	0.3	-0.3	0.1
Bone: trabecular tissue density	0.1	0.1	0.4	-0.7	-0.4	-0.3	0.0	-0.0	0.0
Water consumed over 24 hours	0.1	0.1	0.2	0.5	-0.3	-0.1	-0.1	0.1	-0.3
Number of responses in last shaping day	0.8	0.8	1.3	0.8	1.1	0.7	0.8	-0.8	0.9