Srek1ip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Srek1ip1	0.15	0.09	9.7e-14	0.1	0.1	0.1	0.1	1.1e-11	9.5e-11	2.5e-11	2.7e-11
2	Liver	mRNA stability	Srek1ip1	0.09	0.07	7.4e-07	0.04	0.05	0.05	0.05	6.9e-05	4.3e-06	4.2e-06	7.2e-06
3	Brain	gene expression	Srek1ip1	0.1	0.08	3.1e-07	0.06	0.07	0.08	0.07	3.9e-06	3.0e-07	1.1e-07	2.0e-07
4	PL	gene expression	Srek1ip1	0.09	0.06	2.8e-10	0.1	0.02	0.09	0.04	8.9e-11	1.8e-03	2.0e-10	2.3e-05
5	NAcc	mRNA stability	Srek1ip1	0.08	0.06	1.1e-10	0.09	0.09	0.09	0.05	4.2e-10	6.0e-11	1.4e-10	1.5e-06
6	Adipose	gene expression	Srek1ip1	0.11	0.06	1.1e-16	0.11	0.12	0.12	0.12	4.7e-12	1.5e-13	4.5e-13	4.9e-13
7	Brain	mRNA stability	Srek1ip1	0.12	0.08	5.6e-16	0.18	0.18	0.18	0.18	1.9e-16	7.1e-17	2.3e-16	1.0e-16
8	BLA	mRNA stability	Srek1ip1	0.05	0.04	5.0e-03	0.03	0.04	0.03	0.02	1.7e-02	5.1e-03	1.4e-02	2.6e-02
9	BLA	gene expression	Srek1ip1	0.06	0.05	1.7e-03	0.04	0.03	0.01	0.05	2.9e-03	9.4e-03	1.4e-01	1.1e-03
10	PL	mRNA stability	Srek1ip1	0.07	0.05	1.7e-09	0.09	0.01	0.08	0.02	1.7e-10	1.9e-02	1.9e-09	3.4e-03
11	Adipose	mRNA stability	Srek1ip1	0.18	0.09	0.0e+00	0.2	0.2	0.2	0.2	7.7e-22	8.6e-22	1.1e-21	8.3e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.9	1.5	3.2	1.2	1.8	1.6	1.0	-1.3	-1.1	-1.1	-1.1	-1.0	1.0	1.0
Area under the delay curve	0.3	0.3	0.8	-0.5	0.1	0.2	-0.7	0.3	0.6	0.6	0.6	0.5	-0.4	-0.9
BMI with tail	2.0	6.5	10.0	2.4	3.0	3.2	2.2	-2.8	-2.5	-2.5	-2.5	-2.3	2.4	2.2
BMI without tail	0.5	1.0	2.0	1.0	1.4	1.4	0.7	-1.1	-0.9	-0.9	-0.8	-0.8	0.9	0.6
Body weight	1.5	6.2	9.3	-2.7	-1.7	-1.6	-3.0	2.1	2.5	2.6	2.6	2.7	-2.7	-2.7
Weight adjusted by age	0.1	0.1	0.1	-0.4	-0.1	-0.0	-0.3	0.2	0.3	0.3	0.4	0.3	-0.3	-0.3
Bone surface	0.0	0.0	0.1	0.3	0.2	0.2	0.1	-0.2	-0.1	-0.2	-0.2	-0.2	0.2	0.2
Bone volume	0.1	0.2	0.5	0.6	0.7	0.6	0.4	-0.5	-0.4	-0.4	-0.4	-0.4	0.5	0.4
Breakpoint value in progressive ratio session	2.6	2.8	3.4	1.2	1.7	1.7	1.6	-1.8	-1.8	-1.8	-1.8	-1.7	1.6	1.7
Number of licking bursts	3.1	3.6	4.6	2.0	1.6	1.5	2.0	-1.8	-1.9	-1.9	-1.9	-2.1	2.1	2.0
Context. condit. distance diff. score	1.8	2.1	2.4	-1.4	-1.3	-1.3	-1.5	1.4	1.5	1.5	1.5	1.5	-1.5	-1.5
Locomotion velocity, session 1	0.5	0.5	0.9	-0.9	-0.8	-0.7	-0.7	0.7	0.8	0.7	0.8	0.7	-0.8	-0.6
Locomotion distance, session 1	0.7	0.9	1.0	-1.0	-0.9	-0.9	-1.0	0.9	0.9	1.0	1.0	0.9	-0.9	-1.0
Locomotion velocity, session 2	3.8	4.4	5.6	-2.4	-1.8	-1.7	-2.2	2.0	2.1	2.1	2.2	2.2	-2.1	-2.2
Locomotion distance, session 2	0.7	1.0	1.2	-1.1	-0.8	-0.8	-1.0	0.9	1.0	1.0	1.0	1.1	-1.1	-1.0
Locomotion velocity, session 3	5.1	6.0	7.2	-2.7	-2.2	-2.2	-2.5	2.3	2.5	2.4	2.5	2.6	-2.6	-2.4
Locomotion distance, session 3	8.1	8.9	9.1	-3.0	-3.0	-3.0	-3.0	3.0	3.0	3.0	3.0	3.0	-3.0	-2.9
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.5	-0.2	-0.1	-0.5	0.2	0.4	0.4	0.4	0.4	-0.4	-0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.0	0.5	0.6	0.1	-0.4	-0.2	-0.3	-0.3	-0.2	0.2	0.3
Locomotion velocity, session 7	0.2	0.2	0.4	-0.3	-0.6	-0.5	-0.4	0.5	0.4	0.4	0.4	0.4	-0.4	-0.4
Locomotion distance, session 7	0.4	0.6	0.7	-0.5	-0.8	-0.8	-0.6	0.8	0.8	0.8	0.8	0.8	-0.8	-0.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.0	0.3	0.5	0.1	-0.4	-0.2	-0.3	-0.2	-0.2	0.2	0.4
Stereotopy head waving duration, day 7	0.0	0.0	0.1	-0.3	0.0	0.1	-0.3	-0.0	0.1	0.1	0.1	0.1	-0.2	-0.0
Locomotion velocity, session 8	2.2	2.6	3.1	-1.7	-1.3	-1.2	-1.7	1.5	1.7	1.7	1.7	1.7	-1.7	-1.7
Locomotion distance, session 8	4.2	6.2	6.7	-2.5	-2.3	-2.2	-2.6	2.4	2.6	2.6	2.6	2.6	-2.6	-2.5
Degree of sensitization distance	4.0	4.0	5.1	2.3	1.9	1.9	2.1	-1.9	-2.0	-2.0	-2.0	-2.0	2.0	1.9
Degree of sensitization stereotypy	0.0	0.0	0.1	0.0	0.2	0.4	0.1	-0.3	-0.2	-0.2	-0.2	-0.1	0.1	0.3
Conditioned locomotion	0.1	0.1	0.2	0.5	-0.1	-0.1	0.3	-0.0	-0.2	-0.2	-0.2	-0.3	0.3	0.3
Cocaine response after cond. corrected	1.9	2.2	3.7	-1.3	-1.8	-1.9	-1.3	1.7	1.4	1.4	1.4	1.2	-1.2	-1.3
Cocaine response after cond. not corrected	2.5	2.8	3.9	-1.6	-1.9	-2.0	-1.6	1.8	1.6	1.6	1.6	1.5	-1.5	-1.6
Cocaine response before conditioning	0.3	0.3	0.6	-0.8	-0.2	-0.2	-0.7	0.3	0.6	0.6	0.6	0.7	-0.7	-0.6
Saline control response	1.3	1.7	2.7	-1.6	-1.5	-1.2	-1.2	1.2	1.3	1.3	1.3	1.3	-1.4	-1.2
Bone: connectivity density	0.2	0.3	1.1	0.4	1.0	1.0	0.3	-0.7	-0.4	-0.4	-0.4	-0.3	0.3	0.3
Bone: cortical apparent density	0.1	0.1	0.1	-0.1	-0.1	-0.3	-0.3	0.3	0.3	0.3	0.3	0.3	-0.3	-0.4
Bone: cortical area	0.0	0.0	0.1	-0.1	0.1	0.1	-0.3	0.1	0.2	0.2	0.2	0.2	-0.2	-0.3
Bone: cortical porosity	1.7	1.8	3.0	1.7	1.2	1.0	1.3	-1.2	-1.3	-1.3	-1.4	-1.4	1.3	1.5
Bone: cortical porosity	1.8	1.9	2.9	1.7	1.3	1.2	1.3	-1.3	-1.4	-1.4	-1.4	-1.4	1.3	1.5
Bone: cortical thickness	0.0	0.1	0.3	0.0	0.6	0.4	-0.2	-0.1	0.1	0.1	0.1	0.2	-0.2	-0.3
Bone: cortical thickness	0.7	0.8	1.1	-0.9	-0.5	-0.6	-1.0	0.8	1.0	1.0	1.0	1.0	-1.0	-1.1
Bone: cortical tissue density	0.1	0.1	0.2	-0.1	-0.2	-0.4	-0.3	0.4	0.4	0.4	0.4	0.4	-0.3	-0.4
Condit. Reinf. active minus inactive responses	2.5	2.8	3.8	1.7	1.9	1.8	1.6	-1.8	-1.7	-1.7	-1.6	-1.6	1.6	1.5
Condit. Reinf. active-inactive response ratio	2.4	2.5	2.9	1.6	1.7	1.6	1.5	-1.6	-1.6	-1.6	-1.6	-1.6	1.6	1.5
Condit. Reinf. active responses	0.5	0.6	1.1	0.8	1.1	1.0	0.7	-0.9	-0.7	-0.7	-0.7	-0.6	0.6	0.7
Condit. Reinf. inactive responses	1.1	1.3	1.8	-1.2	-0.8	-0.8	-1.1	1.0	1.2	1.2	1.2	1.3	-1.4	-1.2
Incentive salience index mean	1.7	2.1	2.8	1.5	1.7	1.6	1.3	-1.5	-1.4	-1.4	-1.4	-1.4	1.4	1.3
Condit. Reinf. lever presses	0.4	0.5	0.7	0.8	0.8	0.7	0.7	-0.7	-0.7	-0.7	-0.7	-0.7	0.7	0.7
Condit. Reinf. active minus inactive responses	3.8	4.8	5.9	-2.4	-1.9	-2.1	-2.2	2.1	2.2	2.2	2.2	2.2	-2.2	-2.1
Condit. Reinf. active-inactive response ratio	2.1	2.2	2.7	-1.5	-1.5	-1.7	-1.5	1.6	1.5	1.5	1.5	1.4	-1.4	-1.4
Condit. Reinf. active responses	1.3	1.8	3.1	-1.8	-1.2	-1.1	-1.4	1.2	1.4	1.3	1.4	1.4	-1.5	-1.2
Condit. Reinf. inactive responses	0.1	0.1	0.5	-0.7	-0.1	0.1	-0.3	0.0	0.3	0.3	0.3	0.4	-0.5	-0.3
Condit. Reinf. lever presses	1.6	2.2	3.0	-1.7	-1.3	-1.2	-1.6	1.3	1.5	1.5	1.5	1.5	-1.6	-1.5
Condit. Reinf. lever reinforcers received	1.8	2.5	3.8	-2.0	-1.4	-1.3	-1.6	1.4	1.6	1.6	1.6	1.6	-1.7	-1.5
Conditioned reinforcement - actives	3.2	3.2	5.3	-2.3	-1.9	-1.9	-1.6	1.6	1.6	1.6	1.6	1.8	-1.9	-1.6
Conditioned reinforcement - inactives	0.2	0.2	0.4	-0.6	-0.4	-0.6	-0.3	0.4	0.4	0.4	0.4	0.3	-0.3	-0.3
Conditioned locomotion	0.7	0.9	1.4	-1.2	-0.9	-1.1	-0.9	0.8	0.8	0.8	0.8	1.1	-1.1	-0.9
Patch foraging indifference point 0 sec	3.7	5.9	6.3	-2.4	-2.4	-2.2	-2.5	2.3	2.4	2.4	2.5	2.5	-2.5	-2.5
Patch foraging indifference point AUC	0.8	0.9	1.5	0.6	1.2	1.0	1.2	-1.1	-0.9	-1.0	-0.9	-0.8	0.7	0.9
Delay disc. indifference point, 0s delay	0.2	0.3	0.4	0.6	0.6	0.5	0.4	-0.5	-0.5	-0.5	-0.5	-0.6	0.6	0.3
Delay disc. indifference point, 16s delay	0.9	0.9	1.2	-1.0	-0.7	-0.7	-1.0	0.9	1.1	1.1	1.1	0.9	-0.9	-1.1
Delay disc. indifference point, 2s delay	0.3	0.3	0.8	0.7	0.7	0.9	0.3	-0.6	-0.4	-0.5	-0.4	-0.5	0.6	0.3
Delay disc. indifference point, 24s delay	0.8	0.8	1.1	-0.7	-0.7	-0.7	-1.0	1.0	1.0	1.0	1.0	0.8	-0.6	-1.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.1	0.3	0.4	-0.0	-0.3	-0.2	-0.1	-0.2	-0.1	0.2	-0.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	-0.2	0.5	0.6	-0.3	-0.2	0.2	0.2	0.2	0.1	0.0	-0.4
Indifference point function ln k	4.2	5.9	7.1	-2.2	-2.7	-2.6	-2.5	2.5	2.4	2.4	2.4	2.3	-2.2	-2.4
Indifference point function log k	4.2	5.9	7.1	-2.2	-2.7	-2.6	-2.5	2.5	2.4	2.4	2.4	2.3	-2.2	-2.4
Patch foraging total patch changes 0 sec	4.5	7.2	7.7	-2.6	-2.6	-2.5	-2.8	2.6	2.7	2.7	2.7	2.8	-2.8	-2.8
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	-0.0	0.0	-0.0	0.1	-0.0	-0.0	-0.0	-0.0	0.0	-0.1	-0.1
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.3	0.1	0.2	0.2	-0.1	-0.0	-0.1	-0.0	0.0	-0.1	-0.0
Patch foraging total patch changes 24 sec	0.8	1.0	1.6	-0.6	-1.2	-1.3	-0.9	1.2	1.0	1.0	1.0	0.9	-0.9	-0.9
Patch foraging total patch changes 6 sec	0.5	0.8	1.2	-0.9	-0.7	-0.6	-0.9	0.8	0.9	0.9	1.0	0.9	-0.8	-1.1
Patch foraging time to switch 0 sec	5.7	8.9	12.4	3.5	2.8	2.6	2.9	-2.7	-2.9	-2.9	-2.9	-3.2	3.3	3.0
Patch foraging water rate 0 sec	4.7	7.6	9.1	-3.0	-2.5	-2.4	-2.8	2.6	2.8	2.8	2.8	2.9	-2.9	-2.9
Patch foraging water rate 12 sec	4.8	7.3	9.0	-2.5	-2.9	-3.0	-2.7	2.8	2.7	2.7	2.6	2.5	-2.4	-2.7
Patch foraging water rate 18 sec	5.9	7.9	9.4	-3.1	-2.7	-2.7	-2.9	2.8	2.8	2.8	2.7	2.8	-2.8	-2.9
Patch foraging water rate 24 sec	2.5	3.4	3.9	-1.9	-1.6	-1.7	-1.9	1.8	1.9	1.9	1.9	1.9	-1.9	-2.0
Patch foraging water rate 6 sec	13.5	19.7	20.8	-4.5	-4.4	-4.3	-4.6	4.4	4.5	4.5	4.4	4.4	-4.4	-4.4
Seeking ratio, delayed vs. immediate footshock	1.8	2.1	4.1	1.6	2.0	1.7	1.3	-1.5	-1.3	-1.3	-1.3	-1.1	1.0	1.3
Distance traveled before self-admin	1.9	2.0	2.6	-1.1	-1.3	-1.5	-1.6	1.5	1.5	1.5	1.5	1.3	-1.2	-1.5
Distance traveled after self-admin	1.5	1.6	2.2	-1.1	-1.3	-1.5	-1.3	1.4	1.4	1.4	1.4	1.0	-0.9	-1.2
Extensor digitorum longus weight	4.5	17.7	23.5	3.6	4.6	4.9	3.9	-4.6	-4.2	-4.2	-4.1	-4.0	4.0	4.0
Bone: elastic displacement	1.3	1.4	1.6	1.2	1.1	1.0	1.2	-1.1	-1.2	-1.2	-1.2	-1.3	1.3	1.3
Bone: elastic work	0.6	0.7	0.9	0.9	0.6	0.7	0.9	-0.8	-0.9	-0.9	-0.9	-0.9	0.9	0.9
Bone: endosteal estimation	0.5	1.1	2.9	-0.9	-1.7	-1.5	-0.7	1.2	0.9	0.9	0.8	0.7	-0.7	-0.8
Bone: endosteal perimeter	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.0	-0.1	-0.1	-0.1	-0.1	0.1	0.1
Epididymis fat weight	0.1	0.2	0.6	0.1	0.8	0.7	-0.0	-0.5	-0.3	-0.3	-0.3	-0.1	0.1	0.3
Delta time in closed arm before/after self-admin	3.8	3.7	4.3	2.0	2.1	2.1	1.9	-2.0	-1.8	-1.8	-1.8	-1.9	1.9	1.8
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.0	-0.1	-0.3	0.0	0.1	-0.1	-0.0	-0.1	-0.0	-0.1	0.1
Diff in mean of infusions in LGA sessions	0.3	0.3	0.6	0.2	0.6	0.8	0.4	-0.6	-0.5	-0.5	-0.5	-0.5	0.5	0.7
Delay discount exponential model param	0.3	0.3	0.8	0.5	-0.1	-0.2	0.7	-0.2	-0.6	-0.6	-0.6	-0.4	0.3	0.9
Extinction: sum of active levers before priming	1.6	1.5	1.9	1.1	1.1	1.2	1.3	-1.2	-1.3	-1.3	-1.3	-1.2	1.1	1.4
Active lever presses in extinction session 6	1.7	1.6	2.3	0.9	1.2	1.1	1.4	-1.4	-1.4	-1.4	-1.4	-1.2	1.2	1.5
Bone: final force	0.8	1.3	1.5	-1.1	-1.2	-1.2	-1.1	1.1	1.1	1.1	1.1	1.1	-1.1	-1.1
Bone: final moment	1.0	1.6	2.1	-1.2	-1.4	-1.4	-1.2	1.3	1.3	1.3	1.2	1.2	-1.2	-1.2
Food consumed during 24 hour testing period	0.9	1.1	1.5	-0.9	-1.2	-1.2	-0.9	1.1	1.0	1.0	1.0	0.9	-0.9	-1.0
Glucose	0.9	1.4	1.8	1.1	0.9	0.8	1.3	-1.1	-1.2	-1.3	-1.3	-1.3	1.3	1.2
Heart weight	0.3	0.4	0.6	0.4	0.2	0.3	0.8	-0.5	-0.7	-0.7	-0.7	-0.6	0.6	0.8
Delay discount hyperbolic model param	0.2	0.2	0.5	0.4	-0.2	-0.3	0.6	-0.1	-0.4	-0.4	-0.4	-0.3	0.2	0.7
Intermittent access intake day 1-15 change	0.1	0.1	0.5	0.7	0.2	-0.0	-0.1	0.2	0.1	0.1	0.1	0.1	-0.1	-0.1
Intermittent access intake escalation	0.1	0.1	0.3	0.5	0.1	-0.1	-0.2	0.2	0.2	0.2	0.2	0.3	-0.3	-0.1
Intermittent access intake escalation 2	0.2	0.2	1.0	1.0	0.8	0.5	-0.0	-0.2	-0.1	-0.0	-0.1	0.0	-0.1	0.3
Intermitt. access day 1 inactive lever presses	2.9	3.1	3.5	1.9	1.7	1.7	1.9	-1.7	-1.8	-1.8	-1.7	-1.8	1.8	1.8
Intermitt. access day 15 inactive lever presses	3.4	3.7	4.8	2.2	1.9	1.7	2.1	-1.8	-1.9	-1.9	-1.9	-1.9	1.9	1.9
Intermitt. access escalation Index	0.7	0.6	1.8	-1.3	-1.0	-0.6	-0.8	0.7	0.7	0.6	0.6	0.6	-0.7	-0.5
Intermittent access day 1 total infusions	1.5	1.8	4.5	-2.1	-1.8	-1.6	-0.9	1.2	1.1	1.1	1.1	1.1	-1.1	-1.0
Intermittent access day 15 total infusions	1.7	1.9	2.9	-1.5	-1.7	-1.7	-1.1	1.5	1.3	1.3	1.3	1.3	-1.3	-1.1
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.6	-1.2	-1.2	-1.3	-0.9	1.1	1.0	1.0	1.0	0.9	-1.0	-0.8
Intermittent access total infusions	2.4	2.6	4.6	-2.1	-2.0	-1.8	-1.3	1.6	1.5	1.5	1.5	1.5	-1.5	-1.4
Intermittent access day 1 locomotion	3.6	3.7	5.8	-2.3	-2.4	-2.4	-1.6	1.9	1.7	1.7	1.7	1.8	-1.9	-1.6
Intermittent access day 15 total locomotion	1.8	1.9	3.0	-1.2	-1.5	-1.7	-1.2	1.4	1.3	1.3	1.3	1.4	-1.5	-1.2
Intermittent access total locomotion	5.2	5.9	8.0	-2.5	-2.7	-2.8	-2.2	2.5	2.3	2.3	2.3	2.4	-2.5	-2.3
Intermittent access standard deviation	0.3	0.4	1.1	1.0	0.3	0.0	0.7	-0.3	-0.5	-0.5	-0.5	-0.7	0.6	0.8
Left kidney weight	1.0	2.7	3.5	-1.9	-1.5	-1.3	-1.8	1.4	1.7	1.6	1.7	1.7	-1.7	-1.6
Right kidney weight	0.3	0.8	1.5	-1.2	-0.7	-0.6	-1.0	0.7	0.9	0.9	0.9	1.0	-1.1	-0.9
Cocaine induced anxiety	1.0	1.2	2.1	-1.4	-1.0	-1.0	-1.0	0.9	1.0	1.0	1.0	1.2	-1.2	-1.2
Post-drug Anxiety	1.5	1.7	2.9	-1.7	-1.3	-1.2	-1.2	1.1	1.2	1.2	1.2	1.4	-1.4	-1.3
Baseline Anxiety	0.0	0.0	0.3	0.5	0.2	0.2	-0.2	-0.0	-0.1	-0.0	-0.0	0.0	-0.1	-0.0
Tail length	7.3	22.2	25.2	-4.6	-4.3	-4.3	-5.0	4.7	4.9	4.9	4.9	4.8	-4.7	-4.8
Length with tail	11.2	41.2	46.8	-6.6	-5.8	-5.9	-6.8	6.2	6.5	6.5	6.5	6.6	-6.6	-6.4
Length without tail	7.0	15.3	18.1	-4.3	-3.5	-3.5	-4.2	3.7	3.9	3.9	3.9	4.1	-4.1	-3.9
Times rat made contact with spout	0.3	0.3	0.7	0.6	-0.2	-0.1	0.7	-0.3	-0.6	-0.6	-0.6	-0.8	0.9	0.7
Lifetime Intake	2.0	2.3	3.5	-1.9	-1.8	-1.8	-1.2	1.6	1.4	1.4	1.4	1.4	-1.4	-1.4
Liver weight, left	0.2	0.3	0.8	-0.9	-0.5	-0.3	-0.5	0.4	0.5	0.5	0.5	0.5	-0.6	-0.5
Liver weight, right	0.0	0.0	0.2	-0.4	-0.3	-0.2	0.2	-0.0	-0.1	-0.1	-0.1	-0.1	-0.0	0.4
Locomotor activity	0.5	0.7	1.3	-0.9	-1.1	-1.1	-0.6	0.9	0.8	0.8	0.8	0.9	-0.9	-0.7
Locomotor testing distance	0.2	0.3	0.6	0.4	0.2	0.3	0.8	-0.6	-0.7	-0.7	-0.7	-0.5	0.5	0.8
Locomotor testing rearing	0.1	0.2	0.5	0.0	-0.5	-0.3	0.7	-0.2	-0.5	-0.5	-0.5	-0.4	0.3	0.7
Locomotion in novel chamber	0.6	0.8	1.8	1.3	0.3	0.3	0.8	-0.5	-0.8	-0.8	-0.8	-1.1	1.2	1.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.2	0.3	0.2	0.2	-0.3	-0.1	-0.1	-0.1	-0.4	0.5	-0.0
Fecal boli incidents, locomotor time 1	1.3	1.5	2.8	0.9	0.7	0.7	1.4	-1.2	-1.3	-1.3	-1.3	-1.2	1.1	1.7
Change in fecal boli incidents, locomotor task	0.2	0.2	1.0	1.0	0.6	0.6	0.1	-0.1	-0.2	-0.1	-0.1	-0.3	0.4	-0.2
Time >=10cm from walls, locomotor time 1	1.7	1.8	2.2	1.5	1.1	1.0	1.3	-1.2	-1.4	-1.4	-1.4	-1.4	1.3	1.4
Bouts of movement, locomotor time 1	0.2	0.2	0.5	0.3	-0.0	-0.0	0.6	-0.2	-0.4	-0.4	-0.4	-0.7	0.7	0.7
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.0	-0.4	-0.4	0.2	0.2	-0.0	0.0	-0.0	-0.3	0.3	0.3
Rest time, locomotor task time 1	0.9	1.0	1.8	0.7	0.3	0.3	1.3	-0.9	-1.0	-1.0	-1.0	-1.3	1.2	1.3
Distance moved, locomotor task time 1	1.2	1.3	2.2	-0.7	-0.5	-0.6	-1.3	1.1	1.1	1.2	1.2	1.4	-1.3	-1.5
Vertical activity count, locomotor time 1	0.9	1.0	1.9	-0.5	-0.7	-0.6	-1.2	1.0	1.0	1.1	1.1	1.0	-0.9	-1.4
Time >=10cm from walls, locomotor time 2	1.2	1.3	1.8	1.4	1.3	1.2	1.0	-1.1	-1.1	-1.1	-1.1	-1.1	1.2	0.8
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.7	-0.2	-0.1	-0.5	0.3	0.4	0.4	0.4	0.4	-0.4	-0.5
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	0.0	0.2	-0.0	-0.1	-0.0	-0.0	-0.0	-0.1	0.1	0.0
Rest time, locomotor task time 2	2.7	3.1	5.2	1.5	1.0	1.1	2.0	-1.6	-1.8	-1.8	-1.8	-2.0	2.0	2.3
Distance moved, locomotor task time 2	1.7	2.0	3.1	-1.4	-0.8	-0.7	-1.6	1.1	1.4	1.4	1.4	1.8	-1.8	-1.8
Vertical activity count, locomotor time 2	0.3	0.3	0.8	-0.4	-0.5	-0.4	-0.6	0.5	0.5	0.5	0.5	0.5	-0.5	-0.9
Light reinforcement 1	2.2	4.0	5.7	-2.4	-2.1	-2.0	-1.9	1.9	1.9	1.9	1.9	2.0	-2.1	-1.6
Light reinforcement 2	0.1	0.2	0.2	0.4	0.4	0.2	0.5	-0.4	-0.5	-0.5	-0.5	-0.3	0.2	0.5
Bone: marrow area	0.5	1.0	2.9	-0.9	-1.7	-1.5	-0.7	1.2	0.8	0.9	0.8	0.7	-0.7	-0.8
Bone: maximum diameter	0.5	0.8	1.0	0.8	0.9	1.0	0.9	-1.0	-0.9	-0.9	-0.9	-0.9	0.9	0.9
Bone: maximum force	0.1	0.3	0.4	-0.5	-0.6	-0.5	-0.5	0.5	0.5	0.5	0.5	0.5	-0.5	-0.5
Bone: maximum moment	0.3	0.5	0.7	-0.6	-0.8	-0.8	-0.7	0.7	0.7	0.7	0.7	0.7	-0.6	-0.7
Mean time between licks in bursts	0.2	0.3	0.6	0.3	0.7	0.7	0.5	-0.6	-0.6	-0.5	-0.6	-0.5	0.6	0.3
Mean num. licks in bursts	2.3	2.8	3.4	-1.6	-1.8	-1.7	-1.6	1.7	1.6	1.6	1.6	1.7	-1.7	-1.6
Cd content in liver	0.3	0.4	0.6	-0.6	-0.2	-0.2	-0.8	0.5	0.7	0.7	0.7	0.7	-0.7	-0.8
Co content in liver	0.1	0.2	0.3	-0.3	0.3	0.1	-0.5	0.1	0.4	0.4	0.4	0.5	-0.5	-0.5
Cu content in liver	0.1	0.1	0.2	-0.5	-0.4	-0.3	-0.4	0.3	0.3	0.3	0.4	0.4	-0.4	-0.3
Fe content in liver	1.2	1.4	2.0	-1.4	-1.0	-1.0	-1.2	1.1	1.2	1.2	1.2	1.3	-1.3	-1.2
K content in liver	4.4	4.4	5.8	-1.9	-2.4	-2.4	-2.0	2.3	2.1	2.1	2.1	1.9	-2.0	-1.9
Mg content in liver	1.3	1.4	2.2	-1.1	-1.5	-1.4	-1.1	1.3	1.1	1.1	1.1	1.0	-1.0	-0.9
Mn content in liver	0.4	0.5	0.7	-0.7	-0.7	-0.8	-0.7	0.7	0.7	0.7	0.7	0.6	-0.6	-0.6
Na content in liver	0.4	0.4	0.8	-0.5	-0.8	-0.9	-0.6	0.8	0.7	0.7	0.7	0.5	-0.6	-0.5
Rb content in liver	0.7	0.8	1.1	-0.9	-0.6	-0.7	-1.0	0.8	1.0	1.0	1.0	1.0	-1.0	-1.0
Se content in liver	0.2	0.3	0.7	0.3	0.7	0.8	0.4	-0.7	-0.5	-0.5	-0.5	-0.4	0.4	0.4
Sr content in liver	2.0	1.9	2.2	1.3	1.5	1.4	1.3	-1.4	-1.4	-1.4	-1.4	-1.3	1.3	1.3
Zn content in liver	0.0	0.0	0.0	0.1	0.1	0.1	0.0	-0.0	0.0	0.0	0.0	0.0	0.0	-0.1
Bone: minimum diameter	2.0	3.8	4.9	-1.8	-2.2	-2.1	-1.9	2.0	1.9	1.9	1.9	1.9	-1.8	-1.9
Time in familiar zone, hab. session 1	4.6	4.3	4.6	-2.1	-2.0	-2.0	-2.0	2.0	2.1	2.1	2.1	2.1	-2.1	-2.1
Time in novel zone, hab. session 1	6.9	6.7	6.9	2.6	2.6	2.6	2.5	-2.6	-2.6	-2.6	-2.6	-2.6	2.6	2.6
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.2	0.2	0.3	-0.3	-0.1	0.1	0.2	0.2	0.3	-0.3	-0.2
Total locomotion distance, hab. session 1	0.2	0.3	0.4	-0.6	-0.6	-0.5	-0.5	0.6	0.6	0.5	0.5	0.5	-0.6	-0.4
Locomotion velocity, hab. session 1	0.2	0.3	0.4	-0.6	-0.7	-0.6	-0.5	0.6	0.5	0.5	0.5	0.5	-0.5	-0.3
Time in familiar zone, hab. session 2	2.2	2.3	3.1	-1.4	-1.6	-1.8	-1.4	1.6	1.5	1.5	1.5	1.5	-1.5	-1.3
Time in novel zone, hab. session 2	2.7	2.7	3.7	1.5	1.8	1.9	1.6	-1.7	-1.6	-1.6	-1.6	-1.6	1.6	1.4
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.5	-0.5	-0.6	-0.5	0.6	0.5	0.5	0.5	0.5	-0.5	-0.4
Total locomotion distance, hab. session 2	0.0	0.1	0.2	-0.2	-0.3	-0.5	-0.2	0.3	0.2	0.2	0.2	0.1	-0.2	-0.0
Locomotion velocity, hab. session 2	0.2	0.3	0.7	-0.5	-0.7	-0.8	-0.5	0.7	0.5	0.5	0.6	0.4	-0.5	-0.3
Novel to familiar place preference ratio	2.8	2.8	3.6	1.6	1.8	1.9	1.6	-1.8	-1.6	-1.7	-1.7	-1.7	1.7	1.4
Novelty place preference	2.2	2.2	3.1	1.4	1.7	1.8	1.4	-1.6	-1.5	-1.5	-1.5	-1.5	1.5	1.2
Time in novel zone, NPP test	2.4	2.4	3.4	1.4	1.7	1.8	1.5	-1.7	-1.5	-1.5	-1.5	-1.5	1.6	1.3
Total zone transitions, NPP test	1.6	2.3	2.6	-1.6	-1.4	-1.3	-1.6	1.5	1.5	1.6	1.6	1.6	-1.6	-1.5
Total locomotion distance, NPP test	0.2	0.3	0.5	-0.7	-0.5	-0.5	-0.6	0.6	0.6	0.6	0.6	0.6	-0.6	-0.4
Locomotion velocity, NPP test	0.9	1.3	1.5	-1.2	-1.2	-1.2	-1.1	1.2	1.1	1.1	1.1	1.1	-1.1	-1.0
Intraocular pressure	5.2	7.3	10.6	2.2	3.2	3.3	2.5	-3.1	-2.7	-2.7	-2.7	-2.3	2.2	2.6
Delta distance traveled before/after self-admin	0.6	0.7	0.9	-0.9	-0.9	-0.9	-0.7	0.9	0.9	0.9	0.9	0.5	-0.5	-0.7
Delta ambulatory time before/after self-admin	0.7	0.8	1.1	-0.8	-1.0	-1.0	-0.7	1.0	1.0	1.0	1.1	0.6	-0.6	-0.7
Parametrial fat weight	0.1	0.2	0.8	0.5	0.8	0.9	0.4	-0.5	-0.3	-0.3	-0.3	-0.1	0.1	0.2
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.2	0.1	0.2	0.4	-0.2	-0.3	-0.3	-0.3	-0.3	0.3	0.3
Pavlov. Cond. magazine entry latency	2.3	2.9	3.6	-1.7	-1.2	-1.3	-1.9	1.6	1.8	1.8	1.8	1.9	-1.8	-1.9
Pavlov. Cond. change in total contacts	3.0	3.2	3.9	-1.9	-1.3	-1.4	-2.0	1.6	1.9	1.9	1.9	2.0	-1.9	-2.0
Pavlov. Cond. index score	0.6	0.8	1.0	-0.8	-0.6	-0.7	-1.0	0.8	0.9	0.9	0.9	1.0	-1.0	-1.0
Pavlov. Cond. latency score	0.2	0.3	0.4	-0.5	-0.3	-0.3	-0.6	0.5	0.6	0.5	0.6	0.6	-0.6	-0.6
Pavlov. Cond. lever contacts	0.5	0.6	0.8	-0.7	-0.5	-0.6	-0.9	0.7	0.8	0.8	0.8	0.9	-0.9	-0.9
Pavlov. Cond. magazine entry number	2.6	3.3	3.9	1.8	1.4	1.4	2.0	-1.7	-1.9	-1.9	-1.9	-2.0	2.0	1.9
Pavlov. Cond. intertrial magazine entries	7.4	8.9	12.6	2.7	3.5	3.6	2.8	-3.2	-2.9	-2.9	-2.9	-2.7	2.7	2.7
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.3	-1.0	-0.7	-0.8	-1.1	0.9	1.0	1.0	1.1	1.1	-1.1	-1.1
Pavlov. Cond. response bias	2.5	3.0	3.6	-1.8	-1.4	-1.3	-1.9	1.6	1.8	1.8	1.8	1.9	-1.9	-1.8
Pavlov. Cond. lever latency	1.7	2.3	2.7	1.6	1.3	1.3	1.7	-1.4	-1.6	-1.5	-1.5	-1.6	1.6	1.6
Pavlov. Cond. magazine entry latency	1.2	1.4	1.6	-1.1	-1.2	-1.1	-1.3	1.2	1.1	1.2	1.1	1.1	-1.1	-1.2
Pavlov. Cond. change in total contacts	5.1	7.0	7.4	-2.7	-2.6	-2.6	-2.7	2.6	2.7	2.7	2.7	2.7	-2.6	-2.7
Pavlov. Cond. index score	2.6	3.4	3.9	-1.8	-1.8	-1.7	-2.0	1.8	1.8	1.8	1.8	1.8	-1.8	-1.9
Pavlov. Cond. latency score	2.8	3.4	3.9	-1.8	-1.9	-1.8	-2.0	1.9	1.9	1.9	1.8	1.8	-1.8	-1.9
Pavlov. Cond. lever contacts	1.8	2.5	2.9	-1.7	-1.4	-1.4	-1.7	1.5	1.6	1.6	1.6	1.6	-1.6	-1.6
Pavlov. Cond. magazine entry number	2.3	2.8	3.2	1.6	1.8	1.7	1.7	-1.7	-1.7	-1.7	-1.7	-1.6	1.6	1.7
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.4	-0.6	0.0	0.1	0.0	-0.1	0.1	0.1	0.1	0.3	-0.4	-0.0
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.5	4.1	-1.9	-1.8	-1.7	-2.0	1.8	1.9	1.9	1.9	1.9	-1.9	-1.9
Pavlov. Cond. response bias	1.6	2.2	2.6	-1.6	-1.4	-1.3	-1.6	1.4	1.5	1.5	1.5	1.5	-1.5	-1.5
Time in closed arm before self-admin	0.1	0.1	0.6	-0.2	-0.4	-0.8	-0.1	0.4	0.2	0.2	0.2	0.2	-0.3	-0.1
Time in closed arm after self-admin	0.2	0.2	0.4	0.7	0.4	0.3	0.7	-0.4	-0.4	-0.5	-0.4	-0.4	0.4	0.5
Time in open arm before self-admin	0.1	0.1	0.5	-0.1	0.5	0.7	-0.4	-0.2	0.2	0.2	0.2	0.2	-0.1	-0.4
Time in open arm after self-admin	0.4	0.4	0.6	0.3	0.7	0.7	0.6	-0.8	-0.7	-0.7	-0.7	-0.6	0.6	0.7
Bone: periosteal estimation	0.2	0.4	0.9	-0.5	-0.9	-0.8	-0.5	0.7	0.6	0.6	0.6	0.5	-0.5	-0.6
Bone: periosteal perimeter	0.0	0.0	0.0	-0.2	-0.0	0.0	-0.2	0.0	0.1	0.1	0.2	0.2	-0.2	-0.2
Bone: post-yield work	0.1	0.1	0.4	-0.1	0.5	0.7	0.0	-0.4	-0.2	-0.2	-0.2	-0.1	0.1	0.1
Progressive ratio test 1 active lever presses	1.5	1.5	2.6	-1.6	-1.6	-1.5	-1.0	1.2	1.1	1.1	1.1	1.0	-1.1	-1.0
Progressive ratio test 1 breakpoint	1.8	1.9	3.2	-1.7	-1.8	-1.7	-1.2	1.4	1.2	1.2	1.2	1.1	-1.2	-1.1
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.4	-0.6	-0.4	-0.5	-0.6	0.5	0.6	0.6	0.6	0.6	-0.5	-0.7
Progressive ratio test 2 active lever presses	0.3	0.3	0.7	-0.5	-0.7	-0.8	-0.5	0.6	0.5	0.5	0.5	0.6	-0.6	-0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.4	-0.5	-0.6	-0.3	0.5	0.3	0.4	0.4	0.5	-0.5	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.2	0.3	0.3	0.3	0.3	0.4	-0.5	-0.3
Incentive Sensitization - Responses	0.4	0.4	0.6	-0.1	-0.3	-0.4	-0.7	0.6	0.6	0.6	0.6	0.8	-0.8	-0.7
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.1	-0.1	-0.2	-0.5	0.4	0.4	0.4	0.4	0.6	-0.6	-0.5
Sum of active levers in priming session hrs 5-6	0.9	0.9	1.2	0.4	0.9	0.8	1.1	-1.0	-1.1	-1.1	-1.1	-0.9	0.8	1.0
Progressive ratio	0.2	0.2	0.7	-0.4	0.7	0.8	0.3	-0.6	-0.2	-0.3	-0.2	-0.1	0.0	0.1
Food seeking constrained by brief footshock	2.7	3.3	5.5	-2.0	-2.4	-2.1	-1.6	1.9	1.7	1.7	1.7	1.7	-1.6	-1.7
Seeking ratio, punishment vs. effort	1.2	1.4	3.4	-0.6	-1.8	-1.8	-1.0	1.5	1.0	1.1	1.0	0.8	-0.8	-0.9
Retroperitoneal fat weight	0.9	2.9	3.9	1.7	2.0	2.0	1.5	-1.8	-1.6	-1.6	-1.6	-1.6	1.6	1.7
Reaction time number correct	9.4	13.6	15.6	-4.0	-3.7	-3.6	-3.6	3.6	3.7	3.7	3.7	3.7	-3.7	-3.6
Reaction time mean minus median	0.1	0.1	0.1	-0.0	-0.1	-0.2	-0.4	0.3	0.3	0.3	0.3	0.3	-0.3	-0.2
Reaction time mean minus median AUC	0.4	0.5	0.7	-0.3	-0.5	-0.7	-0.7	0.8	0.7	0.7	0.7	0.8	-0.8	-0.7
Reaction time num false alarms	0.8	1.1	1.7	1.0	1.3	1.3	1.0	-1.2	-1.1	-1.1	-1.1	-0.9	0.9	0.9
Reaction time num false alarms AUC	1.4	1.9	2.5	1.1	1.6	1.6	1.4	-1.5	-1.4	-1.4	-1.4	-1.1	1.1	1.2
Reaction time trials correct on left	9.4	13.6	15.6	-4.0	-3.7	-3.6	-3.6	3.6	3.7	3.7	3.7	3.7	-3.7	-3.6
Reaction time trials on left	9.6	13.7	15.8	-4.0	-3.7	-3.7	-3.6	3.7	3.7	3.7	3.7	3.7	-3.7	-3.6
Reaction time mean	1.7	2.3	4.0	1.6	2.0	1.7	1.3	-1.6	-1.5	-1.4	-1.4	-1.4	1.4	1.5
Reaction time mean AUC	1.4	1.9	3.3	1.5	1.8	1.5	1.1	-1.4	-1.3	-1.3	-1.3	-1.2	1.2	1.4
Median of all reaction times	2.9	4.0	6.3	2.1	2.5	2.2	1.7	-2.1	-1.9	-1.9	-1.9	-1.8	1.8	2.0
Reaction time omissions	0.1	0.1	0.2	-0.1	-0.2	-0.3	-0.4	0.3	0.3	0.3	0.3	0.4	-0.4	-0.2
Reaction time false alarm rate	6.9	9.6	11.4	3.0	3.4	3.3	3.0	-3.3	-3.1	-3.2	-3.1	-2.9	2.8	2.9
Reaction time premature initiation rate	4.7	6.2	7.7	-2.2	-2.8	-2.8	-2.3	2.6	2.4	2.4	2.4	2.5	-2.5	-2.4
Reaction time premature initiations	12.8	18.0	20.1	-4.2	-4.5	-4.4	-4.0	4.3	4.2	4.2	4.2	4.2	-4.3	-4.2
Std. dev. reaction times	0.1	0.1	0.5	0.6	0.7	0.4	0.1	-0.3	-0.3	-0.3	-0.3	-0.2	0.2	0.4
Reaction time trials completed	9.6	13.7	15.8	-4.0	-3.7	-3.7	-3.6	3.7	3.7	3.7	3.7	3.7	-3.7	-3.6
Reaction time trials AUC	8.5	12.2	14.2	-3.8	-3.5	-3.4	-3.4	3.4	3.5	3.5	3.5	3.5	-3.5	-3.4
Run reversals in cocaine runway, females	0.8	0.8	1.8	0.5	1.1	1.4	0.6	-1.0	-0.9	-0.9	-0.9	-0.8	0.7	0.7
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.1	0.2	-0.1	-0.3	0.2	0.3	0.3	0.3	0.4	-0.5	-0.3
Latency to leave start box in cocaine runway	2.0	2.1	3.2	1.1	1.4	1.2	1.7	-1.5	-1.5	-1.5	-1.5	-1.4	1.3	1.8
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	0.3	0.6	0.5	0.7	-0.6	-0.5	-0.6	-0.6	-0.5	0.5	0.8
Latency to leave start box in cocaine runway, M	2.2	2.1	2.4	1.2	1.3	1.4	1.5	-1.5	-1.5	-1.5	-1.5	-1.5	1.5	1.6
Std. dev. time between licks in bursts	0.7	0.8	1.2	1.0	0.7	0.6	0.9	-0.8	-0.9	-0.9	-0.9	-1.1	1.1	1.0
Total sessions with >9 infusions	1.3	1.5	2.6	-1.6	-1.3	-1.3	-1.1	1.1	1.1	1.1	1.1	1.2	-1.4	-0.9
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.2	0.1	0.1	0.2	-0.1	-0.2	-0.1	-0.1	-0.1	0.2	0.1
Short access day 10 total inactive lever presses	0.5	0.5	0.8	0.7	0.7	0.6	0.9	-0.7	-0.7	-0.7	-0.7	-0.7	0.7	0.8
Short access day 1 total infusions	1.1	1.2	1.8	-1.1	-1.3	-1.3	-1.0	1.2	1.0	1.1	1.1	0.9	-0.9	-1.1
Short access day 10 total infusions	1.7	1.9	2.5	-1.4	-1.5	-1.6	-1.1	1.4	1.3	1.3	1.3	1.4	-1.5	-1.2
Short access total infusions	2.0	2.2	3.1	-1.6	-1.8	-1.8	-1.3	1.6	1.4	1.4	1.4	1.3	-1.3	-1.4
Short access day 1 locomotion	0.4	0.4	0.5	-0.7	-0.7	-0.7	-0.7	0.6	0.6	0.6	0.6	0.6	-0.7	-0.5
Short access day 10 total locomotion	0.1	0.1	0.5	0.1	-0.3	-0.7	0.1	0.3	0.1	0.1	0.1	0.3	-0.4	0.1
Short access total locomotion	2.4	2.5	4.2	-1.5	-1.8	-2.0	-1.4	1.7	1.5	1.5	1.5	1.5	-1.6	-1.2
One hour access (0.3 mA shock)	0.9	1.0	2.3	-1.5	-0.8	-0.8	-0.8	0.8	0.9	0.9	0.9	1.2	-1.2	-1.0
Compulsive drug intake	0.3	0.3	0.5	-0.2	0.5	0.6	0.4	-0.7	-0.7	-0.6	-0.6	-0.4	0.3	0.5
One hour access (shock baseline)	2.5	2.9	3.6	-1.8	-1.8	-1.9	-1.4	1.7	1.7	1.7	1.7	1.7	-1.8	-1.5
Social response proportion	0.1	0.1	0.2	-0.4	0.2	0.3	0.3	-0.4	-0.4	-0.4	-0.4	-0.3	0.3	0.3
Social responses	1.7	2.2	3.9	-2.0	-1.4	-1.2	-1.4	1.2	1.3	1.3	1.4	1.7	-1.8	-1.4
Social time	0.0	0.0	0.0	-0.2	0.1	-0.1	0.1	-0.1	-0.2	-0.2	-0.1	-0.1	0.0	0.2
Soleus weight	0.4	1.1	1.9	1.0	1.4	1.3	0.9	-1.2	-1.0	-1.0	-0.9	-0.9	0.9	0.9
Bone: stiffness	0.3	0.5	0.6	-0.8	-0.6	-0.6	-0.8	0.7	0.8	0.7	0.8	0.8	-0.8	-0.8
Tibialis anterior weight	2.5	8.5	9.7	2.6	2.9	3.1	2.8	-3.1	-2.9	-3.0	-2.9	-2.9	2.9	2.8
Time to tail flick, vehicle, before self-admin	4.5	4.6	5.8	-2.3	-2.4	-2.3	-2.1	2.2	2.1	2.1	2.1	2.0	-1.9	-1.9
Time to tail flick, vehicle, after self-admin	1.4	1.5	2.3	-0.9	-0.9	-1.0	-1.5	1.2	1.2	1.2	1.2	1.4	-1.3	-1.5
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.2	-0.2	-0.4	-0.4	0.3	0.3	0.3	0.2	0.3	-0.4	-0.3
Time to tail flick, test, after self-admin	0.5	0.6	1.0	0.5	0.4	0.6	0.9	-0.7	-0.8	-0.8	-0.8	-0.8	0.8	1.0
Delta time to tail flick, vehicle, before/after SA	1.6	1.6	3.0	1.7	1.7	1.5	0.9	-1.3	-1.2	-1.2	-1.2	-1.0	1.0	0.8
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.1	0.0	0.3	0.3	-0.2	-0.2	-0.2	-0.2	-0.3	0.3	0.3
Tibia length	5.9	16.5	17.3	-4.1	-4.1	-4.2	-4.0	4.1	4.1	4.1	4.1	4.0	-4.0	-4.0
Ambulatory time before self-admin	0.6	0.6	0.9	-0.8	-0.6	-0.7	-1.0	0.7	0.8	0.8	0.8	0.6	-0.6	-0.9
Ambulatory time after self-admin	0.9	1.0	1.4	-0.7	-0.9	-1.1	-1.1	1.1	1.2	1.2	1.2	0.7	-0.6	-1.0
Bone: tissue strength	1.0	1.0	1.3	1.1	1.0	0.9	1.0	-1.0	-1.0	-1.0	-1.0	-1.0	1.0	1.1
Total heroin consumption	0.9	1.0	1.9	0.3	0.5	0.7	1.2	-1.0	-1.2	-1.2	-1.2	-1.1	1.0	1.4
Bone: trabecular number	0.1	0.2	0.9	0.2	1.0	0.7	0.1	-0.5	-0.2	-0.2	-0.2	-0.1	0.1	0.1
Bone: trabecular spacing	0.1	0.1	0.2	0.3	-0.2	-0.1	0.4	-0.1	-0.4	-0.3	-0.4	-0.4	0.4	0.4
Bone: trabecular thickness	1.1	1.3	1.7	1.2	1.3	1.3	1.1	-1.2	-1.1	-1.1	-1.1	-1.1	1.1	1.0
Bone: trabecular tissue density	2.0	2.8	3.4	1.8	1.3	1.3	1.8	-1.5	-1.7	-1.7	-1.7	-1.8	1.8	1.8
Water consumed over 24 hours	0.5	0.6	0.9	0.8	0.4	0.3	0.9	-0.6	-0.8	-0.8	-0.8	-0.9	0.9	0.9
Number of responses in last shaping day	0.2	0.2	0.5	-0.2	-0.2	-0.1	0.6	-0.4	-0.5	-0.5	-0.5	-0.7	0.7	0.6