Hub : Genes

Srek1ip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Srek1ip1 0.13 0.07 0.0e+00 0.14 0.14 0.14 0.14 5.5e-15 1.3e-15 1.2e-15 2.1e-15
2 pVTA gene expression Srek1ip1 0.06 0.06 4.3e-03 0.02 -0 0.02 0.02 6.5e-03 4.7e-01 6.7e-03 1.0e-02
3 Liver gene expression Srek1ip1 0.13 0.08 5.8e-13 0.09 0.09 0.09 0.09 1.4e-10 3.9e-10 4.3e-10 2.2e-10
4 BLA gene expression Srek1ip1 0.07 0.05 7.2e-04 0.05 0.01 0.04 0.01 1.0e-03 1.1e-01 2.6e-03 5.2e-02
5 PL mRNA stability Srek1ip1 0.09 0.05 1.7e-11 0.1 0.01 0.1 0.04 3.1e-11 5.1e-02 1.1e-10 1.9e-05
6 Brain mRNA stability Srek1ip1 0.32 0.15 0.0e+00 0.41 0.41 0.4 0.41 9.6e-41 8.0e-41 1.3e-39 2.0e-40
7 PL gene expression Srek1ip1 0.08 0.07 1.5e-08 0.08 0.02 0.07 0.03 5.9e-09 3.1e-03 1.3e-08 7.4e-04
8 BLA mRNA stability Srek1ip1 0.45 0.28 9.4e-12 0.17 0.14 0.16 0.11 2.4e-09 1.3e-07 6.3e-09 1.8e-06
9 IC gene expression Srek1ip1 0.37 0.3 1.3e-05 0.06 0.08 0.07 0.06 1.7e-03 2.1e-04 8.8e-04 1.2e-03
10 NAcc mRNA stability Srek1ip1 0.27 0.21 0.0e+00 0.24 0.25 0.25 0.25 5.9e-36 8.5e-38 2.4e-37 3.0e-37
11 OFC mRNA stability Srek1ip1 0.24 0.18 1.9e-04 0.07 -0 0.08 -0.01 9.1e-03 4.0e-01 4.9e-03 7.2e-01
12 pVTA mRNA stability Srek1ip1 0.1 0.09 4.6e-07 0.08 0 0.09 0.01 7.8e-07 2.6e-01 1.3e-07 3.0e-02
13 Brain gene expression Srek1ip1 0.09 0.07 7.6e-07 0.05 0.07 0.06 0.06 2.8e-05 7.3e-07 1.4e-06 2.3e-06
14 LHb mRNA stability Srek1ip1 0.37 0.2 2.9e-05 0.2 0.1 0.16 0.17 1.9e-05 2.5e-03 9.9e-05 6.1e-05
15 Liver mRNA stability Srek1ip1 0.18 0.1 0.0e+00 0.2 0.19 0.19 0.2 6.5e-22 4.6e-21 5.4e-21 3.8e-22

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.81.42.4-1.2-1.1-1.3-1.3-0.9-1.0-1.0-1.0-1.1-1.1-1.0-0.9-1.4-1.6-1.6
Area under the delay curve0.20.21.00.40.20.10.10.60.50.50.50.20.50.30.8-0.0-0.3-1.0
BMI with tail2.58.515.9-2.5-2.9-2.7-2.8-2.5-2.8-2.6-2.7-3.0-2.8-2.8-2.4-3.4-3.2-4.0
BMI without tail0.72.15.3-1.0-1.4-1.2-1.3-1.0-1.3-1.2-1.2-1.5-1.3-1.2-0.9-1.9-2.2-2.3
Body weight3.113.419.53.93.94.14.14.43.94.14.13.53.93.94.22.70.80.6
Weight adjusted by age0.00.10.20.00.30.50.50.20.20.20.20.10.20.30.3-0.1-0.4-0.0
Bone surface0.00.00.10.2-0.0-0.1-0.20.10.10.10.10.10.00.10.1-0.00.0-0.1
Bone volume0.00.10.2-0.1-0.3-0.4-0.5-0.2-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.3-0.4
Breakpoint value in progressive ratio session3.13.75.6-2.2-1.7-1.6-1.6-1.8-1.9-1.7-1.7-2.1-1.9-2.0-1.9-2.1-2.3-2.4
Number of licking bursts1.82.93.6-1.6-1.8-1.8-1.8-1.9-1.9-1.9-1.9-1.8-1.8-1.8-1.8-1.5-0.9-1.0
Context. condit. distance diff. score1.82.22.71.61.61.61.61.61.51.51.51.51.51.61.51.31.10.8
Locomotion velocity, session 10.40.40.60.70.70.70.70.60.70.80.80.70.70.70.50.50.10.2
Locomotion distance, session 10.60.81.01.00.80.90.91.01.01.01.00.91.00.80.80.90.80.6
Locomotion velocity, session 23.74.35.32.22.22.32.32.22.22.32.32.12.22.22.01.81.11.3
Locomotion distance, session 20.71.01.31.01.01.11.11.01.11.11.11.01.11.01.10.90.50.6
Locomotion velocity, session 35.15.87.22.62.62.72.72.52.52.62.62.52.42.62.42.11.71.2
Locomotion distance, session 37.88.59.73.12.93.03.02.92.93.03.03.02.93.03.02.92.52.5
Stereotopy head waving bouts, day 30.10.10.30.40.30.30.30.50.40.40.40.30.40.30.40.10.3-0.2
Stereotopy head waving duration, day 30.10.21.0-0.2-0.2-0.2-0.2-0.1-0.3-0.2-0.2-0.3-0.3-0.3-0.2-0.6-0.6-1.0
Locomotion velocity, session 70.10.10.20.40.30.30.30.30.30.20.20.40.30.30.20.40.40.5
Locomotion distance, session 70.40.50.70.80.70.70.70.50.70.60.60.80.70.70.70.80.70.8
Stereotopy head waving bouts, day 70.00.00.2-0.0-0.1-0.0-0.00.0-0.10.10.1-0.0-0.1-0.1-0.1-0.3-0.3-0.5
Stereotopy head waving duration, day 70.10.10.20.20.20.30.30.40.20.30.30.20.20.20.2-0.0-0.4-0.4
Locomotion velocity, session 82.32.73.41.81.81.81.81.71.71.81.81.71.71.81.71.40.71.0
Locomotion distance, session 84.46.47.42.72.62.72.72.62.62.62.62.62.62.62.62.32.01.6
Degree of sensitization distance4.14.24.8-2.2-2.2-2.2-2.2-2.2-2.0-2.2-2.2-2.1-2.0-2.2-2.0-1.9-1.6-1.4
Degree of sensitization stereotypy0.00.00.2-0.1-0.1-0.0-0.0-0.1-0.10.00.0-0.1-0.2-0.1-0.2-0.3-0.4-0.5
Conditioned locomotion0.10.11.00.3-0.00.00.00.00.10.10.10.20.10.0-0.20.41.00.4
Cocaine response after cond. corrected2.12.55.01.71.31.31.31.51.51.41.41.61.51.41.21.92.22.2
Cocaine response after cond. not corrected2.52.94.41.81.61.51.51.71.61.61.61.71.71.61.51.92.02.1
Cocaine response before conditioning0.20.20.40.40.60.60.60.60.50.60.60.30.50.50.50.1-0.4-0.5
Saline control response1.21.62.11.41.51.41.41.21.31.41.41.41.31.41.31.10.70.5
Bone: connectivity density0.20.42.0-0.4-0.3-0.4-0.4-0.3-0.3-0.2-0.2-0.5-0.4-0.3-0.2-0.9-1.2-1.4
Bone: cortical apparent density0.00.00.20.10.0-0.1-0.1-0.0-0.00.00.0-0.0-0.00.10.2-0.10.40.0
Bone: cortical area0.10.10.30.40.40.30.20.50.40.50.50.20.40.40.40.1-0.1-0.6
Bone: cortical porosity2.02.13.7-1.6-1.5-1.7-1.6-1.5-1.5-1.5-1.5-1.4-1.5-1.8-1.9-1.1-0.8-0.5
Bone: cortical porosity2.12.23.4-1.6-1.5-1.7-1.6-1.5-1.5-1.5-1.5-1.5-1.5-1.8-1.9-1.2-1.0-0.9
Bone: cortical thickness0.10.21.30.10.1-0.0-0.00.30.10.30.3-0.10.10.20.3-0.3-0.7-1.2
Bone: cortical thickness1.01.21.61.21.21.21.21.21.11.31.31.01.11.21.20.80.4-0.1
Bone: cortical tissue density0.00.00.20.20.1-0.1-0.00.0-0.00.00.00.00.00.10.3-0.00.50.1
Condit. Reinf. active minus inactive responses2.42.74.1-1.8-1.5-1.5-1.5-1.5-1.6-1.6-1.6-1.7-1.6-1.5-1.3-1.8-2.0-1.7
Condit. Reinf. active-inactive response ratio2.22.43.0-1.7-1.6-1.5-1.5-1.5-1.6-1.6-1.6-1.6-1.6-1.5-1.2-1.7-1.6-1.4
Condit. Reinf. active responses0.50.61.4-0.9-0.5-0.5-0.5-0.7-0.7-0.7-0.7-0.8-0.7-0.6-0.5-0.9-1.2-1.1
Condit. Reinf. inactive responses1.01.32.01.11.41.31.31.11.21.21.21.11.21.31.10.90.40.3
Incentive salience index mean1.61.92.8-1.7-1.3-1.3-1.3-1.3-1.4-1.4-1.4-1.5-1.3-1.3-1.1-1.5-1.6-1.4
Condit. Reinf. lever presses0.20.30.5-0.7-0.5-0.5-0.5-0.5-0.5-0.6-0.6-0.6-0.5-0.5-0.4-0.5-0.4-0.5
Condit. Reinf. active minus inactive responses4.45.77.02.52.62.62.62.52.42.62.62.42.42.62.32.21.31.3
Condit. Reinf. active-inactive response ratio2.32.62.91.71.61.71.71.71.61.71.71.61.71.71.51.71.31.3
Condit. Reinf. active responses1.52.12.91.51.61.71.71.51.51.61.61.51.51.71.51.10.70.7
Condit. Reinf. inactive responses0.10.10.30.40.40.40.40.30.30.40.40.40.20.50.4-0.1-0.3-0.2
Condit. Reinf. lever presses1.62.22.81.51.71.71.71.51.51.61.61.51.51.61.51.20.60.5
Condit. Reinf. lever reinforcers received2.02.83.71.81.91.91.91.71.71.91.91.71.71.91.71.40.80.9
Conditioned reinforcement - actives1.93.35.22.12.22.32.21.61.71.81.81.71.82.01.71.61.40.9
Conditioned reinforcement - inactives0.81.22.51.31.00.80.80.91.00.80.91.11.01.00.91.31.61.5
Conditioned locomotion0.81.01.41.21.21.21.10.80.91.11.10.91.01.11.00.91.10.3
Patch foraging indifference point 0 sec2.95.46.62.52.42.32.32.62.52.32.32.52.42.52.52.21.81.6
Patch foraging indifference point AUC0.30.51.6-0.8-0.5-0.5-0.5-0.9-0.6-0.4-0.5-0.6-0.6-0.4-0.4-0.9-1.0-1.3
Delay disc. indifference point, 0s delay0.40.40.7-0.3-0.8-0.8-0.8-0.7-0.6-0.6-0.7-0.6-0.7-0.8-0.7-0.5-0.0-0.7
Delay disc. indifference point, 16s delay0.91.02.01.20.90.80.81.11.11.11.11.11.11.21.40.80.60.2
Delay disc. indifference point, 2s delay0.40.41.4-0.7-0.8-0.8-0.8-0.4-0.5-0.5-0.4-0.6-0.5-0.6-0.1-0.7-0.5-1.2
Delay disc. indifference point, 24s delay0.80.91.61.20.70.60.61.01.01.00.91.01.01.01.00.91.20.3
Delay disc. indifference point, 4s delay0.10.10.8-0.2-0.3-0.4-0.4-0.1-0.1-0.1-0.1-0.4-0.1-0.5-0.2-0.4-0.2-0.9
Delay disc. indifference point, 8s delay0.20.21.60.0-0.3-0.3-0.30.30.20.30.2-0.00.2-0.00.6-0.4-0.9-1.3
Indifference point function ln k2.95.16.32.32.22.22.22.32.32.12.12.32.22.22.12.42.52.5
Indifference point function log k2.95.16.32.32.22.22.22.32.32.12.12.32.22.22.12.42.52.5
Patch foraging total patch changes 0 sec3.66.78.02.82.62.62.62.82.82.72.62.72.72.72.82.41.91.8
Patch foraging total patch changes 12 sec0.00.00.2-0.2-0.1-0.1-0.10.10.2-0.0-0.10.20.10.10.40.0-0.3-0.0
Patch foraging total patch changes 18 sec0.00.00.20.2-0.10.10.1-0.00.1-0.0-0.10.1-0.00.20.3-0.2-0.0-0.5
Patch foraging total patch changes 24 sec0.81.33.11.10.90.90.91.01.11.01.01.31.01.21.21.31.71.4
Patch foraging total patch changes 6 sec0.50.71.70.70.80.90.81.01.00.90.90.91.01.01.30.6-0.1-0.1
Patch foraging time to switch 0 sec4.08.110.3-3.0-3.2-3.0-3.1-2.8-2.9-3.2-3.1-2.9-2.9-3.0-2.9-2.5-1.9-1.7
Patch foraging water rate 0 sec2.96.27.32.52.62.52.52.62.72.72.62.62.62.62.72.41.61.7
Patch foraging water rate 12 sec3.57.28.52.72.62.62.62.82.72.62.62.72.72.52.52.92.92.9
Patch foraging water rate 18 sec4.77.39.02.52.82.82.73.02.92.92.92.72.92.62.62.72.02.3
Patch foraging water rate 24 sec2.63.64.32.12.02.02.02.12.02.01.91.92.01.82.01.81.31.5
Patch foraging water rate 6 sec12.318.019.74.44.34.24.34.44.44.44.44.44.44.34.24.33.53.5
Seeking ratio, delayed vs. immediate footshock1.21.43.9-1.2-0.9-0.8-0.9-1.1-1.1-1.1-1.1-1.2-1.2-0.9-1.0-1.5-2.0-1.5
Distance traveled before self-admin0.60.81.31.00.80.70.71.11.00.90.90.91.00.70.81.00.90.8
Distance traveled after self-admin1.31.62.21.51.01.21.21.41.41.41.41.51.31.21.11.31.20.8
Extensor digitorum longus weight4.417.127.1-4.0-3.9-3.7-3.7-3.9-4.0-3.8-3.9-4.2-4.1-3.9-3.7-4.8-4.9-5.2
Bone: elastic displacement1.72.02.8-1.4-1.6-1.5-1.5-1.5-1.4-1.5-1.5-1.4-1.4-1.7-1.6-1.1-0.7-0.9
Bone: elastic work0.50.61.0-0.7-1.0-0.9-1.0-0.8-0.7-0.8-0.8-0.7-0.8-1.0-0.9-0.4-0.0-0.3
Bone: endosteal estimation0.71.54.11.31.01.01.01.01.10.90.91.31.11.00.81.61.62.0
Bone: endosteal perimeter0.00.10.10.40.20.20.20.20.30.20.20.30.20.30.20.20.40.2
Epididymis fat weight0.72.33.71.31.61.91.81.81.61.81.81.31.61.61.80.8-0.8-0.7
Delta time in closed arm before/after self-admin3.43.23.6-1.9-1.7-1.8-1.8-1.8-1.7-1.7-1.7-1.8-1.8-1.8-1.7-1.9-1.9-1.7
Delta time in open arm before/after self-admin0.20.10.4-0.3-0.4-0.3-0.3-0.3-0.4-0.5-0.5-0.4-0.4-0.4-0.6-0.3-0.3-0.0
Diff in mean of infusions in LGA sessions0.00.00.20.40.30.00.00.20.10.10.10.20.10.30.3-0.00.1-0.2
Delay discount exponential model param0.20.21.1-0.4-0.2-0.1-0.1-0.6-0.5-0.5-0.5-0.2-0.5-0.3-0.80.10.31.0
Extinction: sum of active levers before priming2.62.93.6-1.9-1.6-1.5-1.5-1.7-1.8-1.7-1.7-1.9-1.7-1.7-1.8-1.8-1.4-1.9
Active lever presses in extinction session 62.42.43.3-1.7-1.3-1.5-1.5-1.7-1.7-1.5-1.5-1.6-1.6-1.6-1.8-1.5-1.1-1.4
Bone: final force0.40.60.80.90.90.70.70.80.80.80.80.80.80.80.80.90.90.6
Bone: final moment0.61.01.31.11.10.80.81.01.01.01.01.01.01.01.01.11.20.9
Food consumed during 24 hour testing period0.71.01.40.91.01.01.01.01.01.01.01.01.10.91.01.21.11.0
Glucose0.30.50.8-0.6-0.9-0.8-0.8-0.8-0.7-0.8-0.8-0.6-0.7-0.9-0.8-0.20.40.3
Heart weight0.61.01.51.10.91.21.21.01.00.80.91.01.00.90.91.10.70.8
Delay discount hyperbolic model param0.20.21.1-0.3-0.1-0.0-0.0-0.5-0.5-0.5-0.5-0.2-0.4-0.2-0.70.10.31.0
Intermittent access intake day 1-15 change0.00.00.1-0.00.00.10.0-0.1-0.1-0.2-0.2-0.0-0.1-0.2-0.30.00.20.2
Intermittent access intake escalation0.10.10.30.30.40.40.30.20.30.10.10.40.30.20.00.50.60.5
Intermittent access intake escalation 20.20.20.4-0.3-0.2-0.1-0.2-0.4-0.4-0.6-0.6-0.4-0.4-0.5-0.6-0.5-0.5-0.6
Intermitt. access day 1 inactive lever presses0.41.62.3-1.4-1.1-1.2-1.2-1.3-1.3-1.4-1.4-1.3-1.3-1.1-1.1-1.2-1.5-0.9
Intermitt. access day 15 inactive lever presses0.51.11.8-1.2-1.2-1.1-1.2-1.3-1.1-1.1-1.1-1.1-1.1-1.0-0.9-0.9-0.4-0.7
Intermitt. access escalation Index0.30.50.80.70.80.50.60.80.80.90.90.80.70.70.60.70.20.4
Intermittent access day 1 total infusions1.52.33.71.91.71.51.41.41.51.41.41.61.41.61.41.61.71.2
Intermittent access day 15 total infusions2.33.54.62.22.02.01.91.61.81.61.62.01.81.91.62.12.11.9
Intermittent access terminal intake (last 3 days)1.62.03.01.71.71.61.51.21.41.21.21.51.31.41.11.51.51.3
Intermittent access total infusions3.54.15.42.32.22.12.01.82.01.81.92.12.02.01.92.12.21.8
Intermittent access day 1 locomotion2.83.65.02.22.11.91.91.71.81.81.81.91.81.81.52.02.11.8
Intermittent access day 15 total locomotion2.34.25.52.32.32.12.11.71.91.81.82.11.92.11.82.22.32.2
Intermittent access total locomotion5.56.68.83.02.82.62.62.22.42.32.42.62.52.62.22.72.92.6
Intermittent access standard deviation0.10.22.00.4-0.2-0.0-0.1-0.2-0.1-0.3-0.20.2-0.1-0.1-0.20.51.40.9
Left kidney weight2.310.613.13.33.43.53.53.63.43.53.53.43.43.43.62.81.71.8
Right kidney weight2.210.013.53.23.43.73.63.53.33.43.43.23.33.43.62.61.21.4
Cocaine induced anxiety0.81.11.51.11.01.21.20.91.11.01.01.01.10.80.91.11.10.9
Post-drug Anxiety0.50.60.70.80.70.90.80.70.80.70.70.70.80.70.70.80.80.7
Baseline Anxiety0.30.31.5-0.6-0.4-0.5-0.4-0.4-0.5-0.4-0.4-0.6-0.4-0.3-0.1-0.8-1.2-0.8
Tail length9.035.240.86.36.06.36.36.46.26.16.16.16.26.16.15.73.84.6
Length with tail13.859.874.18.08.28.68.68.58.28.28.27.88.18.08.07.04.24.7
Length without tail9.731.439.25.56.16.26.36.25.96.16.15.75.95.96.04.92.72.8
Times rat made contact with spout0.30.40.7-0.5-0.7-0.7-0.7-0.6-0.6-0.6-0.6-0.5-0.5-0.8-0.8-0.10.30.4
Lifetime Intake2.73.34.42.11.91.91.81.61.81.71.71.91.81.91.81.91.91.6
Liver weight, left3.86.28.22.62.72.52.62.82.72.72.72.52.72.72.92.21.41.3
Liver weight, right0.00.10.50.30.00.10.00.10.10.10.10.0-0.00.20.3-0.4-0.3-0.7
Locomotor activity0.30.50.80.60.90.90.90.60.70.90.80.70.70.70.50.80.30.4
Locomotor testing distance0.20.30.5-0.5-0.4-0.6-0.6-0.6-0.6-0.5-0.6-0.5-0.6-0.5-0.7-0.5-0.6-0.5
Locomotor testing rearing0.10.20.60.1-0.3-0.4-0.4-0.5-0.4-0.4-0.5-0.2-0.4-0.4-0.80.10.30.5
Locomotion in novel chamber0.40.61.0-0.9-1.0-0.9-0.9-0.8-0.7-1.0-1.0-0.6-0.7-0.7-0.9-0.20.3-0.0
Locomotion in novel chamber post-restriction0.00.00.1-0.0-0.2-0.1-0.1-0.2-0.1-0.3-0.3-0.1-0.1-0.00.0-0.1-0.4-0.2
Fecal boli incidents, locomotor time 10.81.12.3-1.0-0.9-0.8-0.9-1.3-1.2-1.2-1.1-1.0-1.2-1.1-1.5-1.0-0.8-0.5
Change in fecal boli incidents, locomotor task0.10.10.2-0.4-0.4-0.3-0.3-0.1-0.1-0.3-0.4-0.2-0.10.10.5-0.2-0.30.0
Time >=10cm from walls, locomotor time 11.81.93.0-1.0-1.5-1.2-1.2-1.5-1.6-1.7-1.7-1.5-1.6-1.4-1.6-1.4-0.8-0.6
Bouts of movement, locomotor time 10.20.30.7-0.4-0.4-0.6-0.6-0.6-0.5-0.6-0.6-0.3-0.5-0.6-0.9-0.10.20.5
Total resting periods, locomotor time 10.10.10.70.10.0-0.1-0.2-0.2-0.0-0.1-0.10.2-0.1-0.1-0.40.40.50.8
Rest time, locomotor task time 10.40.51.3-0.7-0.7-0.7-0.8-0.9-0.8-0.8-0.7-0.6-0.8-0.8-1.1-0.3-0.00.1
Distance moved, locomotor task time 10.71.02.11.20.90.91.11.21.01.01.00.91.01.21.50.70.40.3
Vertical activity count, locomotor time 10.30.71.20.80.60.60.81.01.00.80.90.80.90.91.10.80.60.5
Time >=10cm from walls, locomotor time 21.01.51.8-1.1-1.3-1.3-1.2-1.2-1.2-1.3-1.3-1.2-1.3-1.1-0.9-1.3-1.3-1.2
Bouts of movement, locomotor time 20.10.20.40.60.50.50.40.50.40.50.50.40.40.50.60.20.00.1
Total resting periods, locomotor time 20.00.00.00.20.10.0-0.1-0.0-0.10.10.1-0.0-0.10.00.1-0.1-0.10.1
Rest time, locomotor task time 22.22.85.4-1.9-1.6-1.5-1.7-1.9-1.9-1.7-1.7-1.7-1.8-1.9-2.3-1.3-0.5-0.5
Distance moved, locomotor task time 21.11.43.01.51.01.11.31.41.21.21.21.01.21.41.70.70.1-0.2
Vertical activity count, locomotor time 20.10.10.30.50.1-0.00.20.40.40.30.30.30.40.30.60.30.40.0
Light reinforcement 11.74.15.62.32.22.42.41.92.02.22.22.22.02.11.81.91.41.3
Light reinforcement 20.10.10.4-0.1-0.1-0.3-0.2-0.6-0.4-0.2-0.2-0.4-0.4-0.4-0.6-0.3-0.2-0.5
Bone: marrow area0.71.54.11.31.01.01.01.01.10.90.91.21.11.00.81.51.72.0
Bone: maximum diameter0.20.41.2-0.5-0.5-0.5-0.6-0.5-0.6-0.5-0.5-0.7-0.6-0.6-0.6-0.8-0.8-1.1
Bone: maximum force0.10.20.20.40.50.30.30.50.50.40.40.40.40.40.50.40.30.1
Bone: maximum moment0.30.50.60.70.70.60.50.80.70.70.70.70.70.70.70.70.70.4
Mean time between licks in bursts0.20.40.5-0.6-0.7-0.6-0.6-0.6-0.6-0.6-0.6-0.7-0.6-0.6-0.4-0.7-0.6-0.5
Mean num. licks in bursts1.32.12.51.31.41.41.41.51.61.51.51.51.51.41.31.61.31.5
Cd content in liver1.21.32.41.11.31.31.31.31.21.31.31.01.21.31.60.7-0.4-0.2
Co content in liver0.10.10.7-0.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.3-0.2-0.3-0.2-0.4-0.8-0.8
Cu content in liver0.00.00.10.20.10.10.10.10.10.10.10.10.20.10.20.20.30.3
Fe content in liver1.01.31.81.21.31.21.21.21.21.21.21.11.21.21.31.00.60.5
K content in liver2.32.24.21.61.51.31.31.31.41.31.31.51.41.41.11.72.02.0
Mg content in liver0.20.21.20.40.30.30.30.30.30.30.30.40.30.30.10.61.01.1
Mn content in liver0.50.61.00.80.80.80.80.80.70.80.80.80.80.80.60.80.81.0
Na content in liver0.00.00.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.1-0.0-0.00.10.30.2
Rb content in liver1.21.51.81.21.31.41.41.41.31.41.41.21.31.21.11.10.70.8
Se content in liver0.81.01.6-1.1-0.9-1.0-1.0-1.0-0.9-1.0-1.0-1.0-1.0-1.0-0.9-1.1-1.2-0.9
Sr content in liver2.21.92.2-1.5-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.5-1.3-1.3-1.1
Zn content in liver0.20.20.30.40.40.40.40.40.50.40.40.50.50.40.50.60.30.4
Bone: minimum diameter2.44.56.22.32.01.91.82.22.22.12.12.22.22.02.02.32.51.9
Time in familiar zone, hab. session 14.14.04.52.12.12.12.12.02.12.12.12.12.12.12.01.91.61.4
Time in novel zone, hab. session 16.56.57.5-2.7-2.5-2.6-2.6-2.5-2.6-2.5-2.5-2.6-2.6-2.6-2.5-2.6-2.6-2.3
Total zone transitions, hab. session 10.10.11.0-0.10.10.20.20.20.10.10.1-0.00.10.00.1-0.3-1.0-0.8
Total locomotion distance, hab. session 10.20.30.50.60.50.70.70.50.50.60.60.60.50.50.40.60.70.4
Locomotion velocity, hab. session 10.20.30.50.60.50.60.60.50.40.60.60.60.50.50.40.60.70.4
Time in familiar zone, hab. session 22.32.43.01.71.51.51.51.41.61.51.51.61.51.51.31.71.71.7
Time in novel zone, hab. session 22.93.04.2-1.9-1.6-1.6-1.6-1.6-1.7-1.6-1.6-1.8-1.7-1.6-1.5-1.9-2.0-2.1
Total zone transitions, hab. session 20.10.20.20.50.30.50.50.40.40.40.40.40.40.30.20.40.50.2
Total locomotion distance, hab. session 20.00.00.20.20.10.20.20.20.10.20.20.20.10.1-0.00.30.40.1
Locomotion velocity, hab. session 20.20.30.80.50.40.50.50.50.40.50.50.60.50.50.40.70.90.5
Novel to familiar place preference ratio2.62.94.4-1.8-1.7-1.6-1.6-1.6-1.6-1.7-1.7-1.7-1.7-1.7-1.5-1.8-2.1-1.5
Novelty place preference2.22.34.4-1.6-1.4-1.4-1.4-1.4-1.4-1.5-1.5-1.5-1.5-1.5-1.3-1.7-2.1-1.5
Time in novel zone, NPP test2.42.54.8-1.7-1.5-1.4-1.4-1.5-1.5-1.5-1.5-1.6-1.5-1.5-1.3-1.8-2.2-1.6
Total zone transitions, NPP test1.31.92.41.51.41.51.51.51.41.51.51.41.41.41.31.31.00.9
Total locomotion distance, NPP test0.20.30.50.60.60.70.70.60.50.70.70.50.60.50.50.50.60.3
Locomotion velocity, NPP test0.91.31.81.21.11.21.21.11.01.21.21.11.11.11.01.21.41.1
Intraocular pressure4.76.811.7-2.5-2.2-2.1-2.1-2.4-2.5-2.3-2.3-2.8-2.5-2.5-2.6-3.1-3.2-3.4
Delta distance traveled before/after self-admin1.31.42.01.41.01.21.21.01.21.21.21.41.01.31.21.21.11.1
Delta ambulatory time before/after self-admin1.21.52.01.41.01.21.21.01.21.21.21.41.11.41.21.31.21.2
Parametrial fat weight0.10.21.80.10.10.10.10.10.10.10.2-0.10.00.20.3-0.5-1.1-1.3
Pavlov. Cond. lever latency0.00.00.1-0.1-0.2-0.1-0.1-0.2-0.1-0.1-0.1-0.1-0.1-0.2-0.3-0.0-0.3-0.0
Pavlov. Cond. magazine entry latency1.72.23.71.41.61.61.61.61.51.51.51.51.51.71.91.20.70.4
Pavlov. Cond. change in total contacts2.93.14.01.72.01.91.91.91.81.91.91.71.92.02.01.40.80.6
Pavlov. Cond. index score0.60.81.60.81.00.90.91.00.90.90.90.90.91.11.30.70.60.3
Pavlov. Cond. latency score0.20.30.80.40.60.50.50.60.50.50.50.50.50.70.90.30.30.1
Pavlov. Cond. lever contacts0.60.81.30.81.00.90.91.00.90.90.90.80.91.01.10.70.70.4
Pavlov. Cond. magazine entry number2.83.65.4-1.9-2.0-2.0-2.0-2.1-2.0-2.0-2.0-1.9-2.0-2.1-2.3-1.6-1.1-0.8
Pavlov. Cond. intertrial magazine entries7.18.514.8-3.1-2.6-2.6-2.6-2.7-2.8-2.6-2.6-3.1-2.8-2.7-2.7-3.4-3.8-3.2
Pavlov. Cond. lever-magazine prob. diff.0.81.01.91.01.11.01.01.11.01.01.01.01.11.21.40.80.70.4
Pavlov. Cond. response bias2.53.14.41.82.01.91.91.91.81.91.91.81.82.02.11.51.10.7
Pavlov. Cond. lever latency2.23.03.8-1.7-1.9-1.9-1.9-1.9-1.8-1.9-1.9-1.8-1.8-1.9-2.0-1.5-0.8-0.7
Pavlov. Cond. magazine entry latency1.21.41.61.31.21.31.31.31.21.21.21.21.31.21.21.21.10.8
Pavlov. Cond. change in total contacts4.16.57.82.62.72.72.72.72.72.62.62.62.72.82.82.51.71.7
Pavlov. Cond. index score2.43.23.61.81.91.91.91.91.91.91.91.81.91.91.91.71.20.9
Pavlov. Cond. latency score2.43.23.61.91.91.91.91.91.91.91.91.81.91.81.91.81.31.1
Pavlov. Cond. lever contacts1.62.22.91.51.71.61.61.61.61.61.61.51.61.71.71.30.60.4
Pavlov. Cond. magazine entry number2.42.93.3-1.8-1.7-1.8-1.8-1.8-1.7-1.8-1.8-1.7-1.8-1.7-1.6-1.7-1.5-1.3
Pavlov. Cond. intertrial magazine entries0.00.00.20.10.30.20.20.10.10.20.20.10.10.2-0.0-0.1-0.5-0.2
Pavlov. Cond. lever-magazine prob. diff.2.43.33.81.81.92.02.01.91.91.91.91.81.91.91.91.71.10.9
Pavlov. Cond. response bias1.41.92.51.41.51.51.51.51.41.51.51.41.51.51.61.20.60.4
Time in closed arm before self-admin0.40.50.80.80.60.80.80.50.60.60.60.70.60.60.40.80.90.8
Time in closed arm after self-admin0.00.00.00.10.0-0.0-0.0-0.20.00.00.00.1-0.00.0-0.10.10.20.2
Time in open arm before self-admin0.10.10.50.20.20.20.20.40.20.20.20.10.20.30.6-0.2-0.7-0.6
Time in open arm after self-admin0.80.91.5-1.1-0.8-0.6-0.6-0.9-1.0-1.0-1.0-1.1-0.9-0.9-0.9-1.1-1.2-0.9
Bone: periosteal estimation0.30.71.01.00.80.70.70.80.90.80.80.80.80.70.70.90.90.9
Bone: periosteal perimeter0.10.20.30.50.50.40.30.50.40.50.50.30.40.50.60.1-0.0-0.4
Bone: post-yield work0.20.30.60.20.50.50.40.50.40.50.50.20.40.60.7-0.2-0.7-0.8
Progressive ratio test 1 active lever presses2.53.04.32.11.81.61.61.51.71.51.41.81.61.81.71.92.02.0
Progressive ratio test 1 breakpoint2.73.34.62.11.81.71.71.61.71.51.51.91.71.91.81.92.02.0
Progressive ratio test 1 inactive lever presses0.50.71.01.00.80.50.50.81.00.70.80.91.00.81.00.90.70.6
Progressive ratio test 2 active lever presses2.73.14.42.12.11.91.91.61.71.61.61.81.71.71.51.81.81.6
Progressive ratio test 2 breakpoint2.93.34.72.22.12.01.91.71.81.61.61.81.81.81.61.91.91.6
Progressive ratio test 2 inactive lever presses0.61.01.71.31.21.11.10.81.00.90.91.00.91.10.91.01.00.5
Incentive Sensitization - Responses2.43.44.92.02.21.91.91.91.92.02.01.82.01.81.61.81.51.2
Incentive Sensitization - Breakpoint2.12.74.01.82.01.71.71.71.71.81.81.61.81.61.41.61.31.0
Sum of active levers in priming session hrs 5-61.91.72.6-1.6-1.0-1.0-1.0-1.5-1.5-1.1-1.1-1.5-1.3-1.3-1.4-1.4-1.4-1.4
Progressive ratio0.30.52.10.20.50.70.70.10.10.30.30.00.10.80.9-0.5-1.3-1.4
Food seeking constrained by brief footshock2.73.34.11.71.71.81.81.81.81.71.71.81.81.81.82.02.02.0
Seeking ratio, punishment vs. effort1.21.87.61.10.70.70.61.11.10.90.91.21.10.50.31.82.62.8
Retroperitoneal fat weight0.10.41.90.20.30.30.30.60.50.60.60.20.40.30.4-0.3-1.2-1.4
Reaction time number correct6.813.015.33.93.93.83.83.63.73.83.83.73.73.53.23.62.83.1
Reaction time mean minus median0.00.00.10.40.10.20.10.10.10.20.20.20.20.30.30.10.30.2
Reaction time mean minus median AUC0.20.40.70.80.60.80.70.50.50.70.70.60.60.60.50.60.80.9
Reaction time num false alarms0.50.61.0-0.7-0.8-0.7-0.6-0.8-0.9-0.8-0.8-0.9-0.9-0.8-0.7-1.0-0.5-1.0
Reaction time num false alarms AUC0.81.31.9-0.9-1.1-1.0-0.9-1.2-1.3-1.1-1.1-1.3-1.2-1.2-1.1-1.4-0.8-1.3
Reaction time trials correct on left6.813.015.33.93.93.83.83.63.73.83.83.73.73.53.23.62.83.1
Reaction time trials on left7.013.115.43.93.93.83.83.63.73.83.83.73.73.53.23.62.93.2
Reaction time mean1.72.73.1-1.5-1.7-1.6-1.6-1.6-1.7-1.6-1.7-1.7-1.7-1.5-1.6-1.7-1.4-1.7
Reaction time mean AUC1.42.22.4-1.4-1.6-1.5-1.5-1.5-1.6-1.5-1.5-1.5-1.5-1.4-1.5-1.6-1.2-1.5
Median of all reaction times3.14.45.0-2.1-2.1-2.1-2.1-2.0-2.1-2.1-2.1-2.1-2.2-2.0-2.0-2.2-2.0-2.2
Reaction time omissions0.30.40.80.70.80.80.80.50.40.60.60.50.50.70.40.50.60.9
Reaction time false alarm rate5.98.29.7-2.9-3.0-2.8-2.7-2.9-3.0-2.9-2.9-3.0-3.0-2.8-2.6-3.1-2.4-2.9
Reaction time premature initiation rate4.25.87.52.42.42.42.42.22.42.32.32.52.52.32.22.72.72.6
Reaction time premature initiations9.517.019.14.44.24.24.23.94.14.14.24.24.24.03.74.34.04.0
Std. dev. reaction times0.10.20.3-0.2-0.6-0.4-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.4-0.4-0.5-0.2-0.3
Reaction time trials completed7.013.115.43.93.93.83.83.63.73.83.83.73.73.53.23.62.93.2
Reaction time trials AUC6.211.713.93.73.73.63.63.43.53.63.63.53.53.43.03.42.63.0
Run reversals in cocaine runway, females0.70.72.1-1.0-0.7-0.3-0.3-0.6-0.8-0.6-0.6-1.0-0.7-0.7-0.6-1.2-0.8-1.5
Run reversals in cocaine runway, males0.10.10.30.40.30.60.60.20.30.50.50.20.30.10.10.1-0.5-0.0
Latency to leave start box in cocaine runway1.82.12.6-1.4-1.6-1.3-1.3-1.5-1.5-1.5-1.5-1.5-1.5-1.6-1.6-1.4-1.0-1.1
Latency to leave start box in cocaine runway, F0.20.20.4-0.2-0.6-0.4-0.4-0.5-0.5-0.5-0.5-0.4-0.5-0.6-0.6-0.20.00.1
Latency to leave start box in cocaine runway, M2.12.02.2-1.5-1.5-1.4-1.3-1.4-1.4-1.3-1.3-1.5-1.4-1.4-1.4-1.5-1.2-1.4
Std. dev. time between licks in bursts0.40.50.8-0.7-0.9-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.8-0.8-0.8-0.6-0.3-0.2
Total sessions with >9 infusions0.70.91.31.11.01.00.90.80.90.90.91.00.91.01.01.00.80.7
Short access day 1 total inactive lever presses0.60.81.51.00.90.80.81.11.10.90.81.01.01.01.20.90.30.4
Short access day 10 total inactive lever presses0.10.30.6-0.5-0.3-0.4-0.4-0.5-0.5-0.5-0.5-0.7-0.5-0.5-0.7-0.7-0.6-0.8
Short access day 1 total infusions0.30.40.70.80.70.60.60.70.70.60.50.70.60.70.70.80.50.7
Short access day 10 total infusions1.72.12.91.71.61.61.51.31.41.41.41.51.41.61.61.41.21.1
Short access total infusions1.11.41.81.31.21.21.11.11.21.21.11.31.11.31.41.21.01.0
Short access day 1 locomotion0.10.10.40.40.60.50.40.30.30.50.40.30.30.30.20.20.00.0
Short access day 10 total locomotion0.30.51.5-0.4-0.4-0.6-0.7-0.9-0.9-0.7-0.7-0.7-0.8-0.8-1.2-0.6-0.1-0.2
Short access total locomotion0.50.61.21.00.90.70.60.60.60.80.70.80.60.80.50.91.11.0
One hour access (0.3 mA shock)2.22.64.22.02.11.91.81.41.51.61.61.61.51.91.71.30.80.6
Compulsive drug intake1.72.02.9-1.4-1.1-1.3-1.3-1.3-1.5-1.2-1.3-1.6-1.4-1.3-1.4-1.7-1.6-1.5
One hour access (shock baseline)3.55.37.02.62.42.32.32.12.32.22.22.52.32.42.32.52.32.0
Social response proportion0.10.10.7-0.1-0.2-0.1-0.2-0.1-0.3-0.0-0.1-0.4-0.3-0.1-0.2-0.5-0.9-0.4
Social responses1.31.72.71.41.51.71.61.31.31.61.61.21.31.51.40.90.00.4
Social time0.00.00.0-0.10.00.0-0.0-0.1-0.10.10.1-0.0-0.10.0-0.1-0.1-0.10.2
Soleus weight0.41.12.3-0.9-0.9-0.8-0.8-0.9-0.9-0.9-0.9-1.0-1.0-0.8-0.9-1.3-1.5-1.5
Bone: stiffness0.20.30.60.40.70.60.50.70.60.60.60.50.60.70.70.40.1-0.0
Tibialis anterior weight2.79.011.0-3.0-3.0-2.8-2.8-3.0-3.0-3.0-3.0-3.1-3.0-2.9-2.7-3.3-3.1-3.3
Time to tail flick, vehicle, before self-admin2.02.13.21.71.31.31.31.31.31.51.51.51.41.31.21.61.81.7
Time to tail flick, vehicle, after self-admin0.00.00.2-0.10.00.20.20.20.10.00.0-0.10.2-0.10.10.10.20.5
Time to tail flick, test, before self-admin0.10.10.2-0.2-0.4-0.2-0.2-0.4-0.4-0.4-0.4-0.3-0.4-0.3-0.4-0.1-0.10.2
Time to tail flick, test, after self-admin1.21.32.1-1.2-1.4-1.4-1.4-1.3-1.2-1.1-1.1-1.0-1.2-1.3-1.3-0.8-0.3-0.0
Delta time to tail flick, vehicle, before/after SA1.21.22.2-1.5-1.0-0.9-0.9-0.8-1.0-1.1-1.1-1.3-0.9-1.2-1.0-1.2-1.3-1.0
Delta time to tail flick, test, before/after SA0.00.00.1-0.2-0.1-0.2-0.2-0.10.00.00.00.00.0-0.0-0.10.00.30.2
Tibia length6.217.218.74.34.24.24.24.24.24.24.14.34.24.24.24.23.73.8
Ambulatory time before self-admin0.10.10.30.40.30.20.20.50.40.40.40.30.40.10.10.30.3-0.0
Ambulatory time after self-admin1.01.21.71.30.91.01.01.21.21.11.11.31.11.01.01.11.10.8
Bone: tissue strength0.80.81.2-1.1-0.9-1.0-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.8-0.7-0.5
Total heroin consumption1.01.21.8-1.1-1.2-0.9-0.9-1.2-1.2-1.3-1.3-1.1-1.2-1.2-1.2-1.0-0.4-0.5
Bone: trabecular number0.10.21.0-0.2-0.0-0.2-0.20.10.00.00.0-0.2-0.10.00.0-0.5-0.9-1.0
Bone: trabecular spacing0.20.20.6-0.3-0.4-0.5-0.4-0.5-0.4-0.5-0.5-0.3-0.4-0.5-0.60.00.70.8
Bone: trabecular thickness0.70.92.3-0.8-0.8-0.7-0.8-0.8-0.9-0.8-0.8-1.0-0.9-0.8-0.8-1.1-1.0-1.5
Bone: trabecular tissue density2.23.24.4-2.0-1.9-1.9-1.9-1.9-2.0-1.9-1.9-1.9-1.9-1.9-2.1-1.5-0.8-0.5
Water consumed over 24 hours0.40.61.1-0.7-0.8-0.9-0.9-0.8-0.8-0.8-0.8-0.7-0.8-1.0-1.0-0.4-0.1-0.2
Number of responses in last shaping day0.50.61.0-0.6-0.9-0.6-0.7-1.0-0.8-1.0-1.0-0.6-0.9-0.7-0.6-0.5-0.2-0.4