Hub : Genes

Srek1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain alternative TSS XM_039102994.1 0.03 0.03 6.9e-04 0.03 0.03 0.02 0.03 4.5e-04 1.5e-03 2.3e-03 1.7e-03
2 Adipose alternative TSS NM_001412515.1 0.03 0.03 2.9e-03 0.01 0.02 0.02 0.02 6.9e-03 5.0e-03 5.0e-03 6.3e-03
3 Brain gene expression Srek1 0.03 0.03 2.4e-03 0.01 0.02 0.01 0.01 2.2e-02 4.5e-03 1.5e-02 2.3e-02
4 NAcc gene expression Srek1 0.03 0.03 2.4e-04 0.03 0.03 0.03 0.03 3.1e-04 1.2e-04 1.3e-04 1.7e-04
5 Brain isoform ratio XR_005500355.1 0.04 0.03 1.4e-04 0.03 0.04 0.02 0.03 8.1e-04 1.4e-04 3.5e-03 1.1e-03
6 PL gene expression Srek1 0.06 0.05 9.2e-07 0.05 0.06 0.05 0.01 3.5e-06 6.5e-07 3.9e-06 7.1e-03
7 PL alternative TSS XM_039102994.1 0.02 0.02 7.5e-03 0.01 0.02 0.01 0.01 9.3e-03 2.8e-03 1.9e-02 2.8e-02
8 NAcc intron excision ratio chr2_34872488_34877765 0.02 0.02 8.0e-03 0.01 0.01 0.01 0.01 7.2e-03 1.6e-02 2.3e-02 1.4e-02
9 OFC intron excision ratio chr2_34872488_34877765 0.2 0.16 4.8e-03 0.09 0.02 0.09 0.04 4.7e-03 1.1e-01 4.7e-03 4.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.81.42.0-1.21.1-1.1-1.1-1.1-1.11.21.21.4
Area under the delay curve0.20.20.40.5-0.60.50.50.50.3-0.3-0.2-0.6
BMI with tail2.16.97.9-2.52.6-2.6-2.6-2.6-2.72.72.52.8
BMI without tail0.40.91.2-0.90.9-0.9-0.9-0.9-1.01.00.81.1
Body weight1.56.27.32.7-2.62.62.62.52.5-2.4-2.5-2.0
Weight adjusted by age0.40.51.70.4-0.60.60.60.60.7-0.7-0.5-1.3
Bone surface0.10.30.9-0.20.4-0.4-0.4-0.4-0.50.50.51.0
Bone volume0.30.51.3-0.50.6-0.6-0.6-0.6-0.70.70.71.1
Breakpoint value in progressive ratio session3.13.54.6-1.61.8-1.8-1.9-1.9-1.91.92.11.7
Number of licking bursts3.54.14.3-1.92.0-2.0-2.0-2.1-2.12.12.02.1
Context. condit. distance diff. score1.11.42.01.4-1.21.21.21.21.1-1.1-1.0-0.9
Locomotion velocity, session 10.30.40.40.5-0.60.60.60.60.6-0.6-0.6-0.7
Locomotion distance, session 10.50.60.70.9-0.80.80.80.80.7-0.7-0.8-0.4
Locomotion velocity, session 23.94.55.21.9-2.22.22.22.22.2-2.2-2.3-1.9
Locomotion distance, session 20.30.40.60.7-0.80.70.80.70.6-0.6-0.6-0.3
Locomotion velocity, session 33.84.54.82.0-2.22.22.22.22.1-2.1-2.1-1.9
Locomotion distance, session 36.06.57.22.7-2.62.62.72.62.5-2.5-2.5-2.1
Stereotopy head waving bouts, day 30.40.50.60.6-0.70.70.70.70.7-0.8-0.7-0.8
Stereotopy head waving duration, day 30.00.00.1-0.0-0.00.00.00.00.1-0.1-0.2-0.2
Locomotion velocity, session 70.30.31.00.3-0.40.40.40.40.5-0.5-0.5-1.0
Locomotion distance, session 70.50.60.90.8-0.70.70.70.70.7-0.7-0.7-0.9
Stereotopy head waving bouts, day 70.00.00.3-0.10.2-0.2-0.1-0.2-0.10.1-0.10.5
Stereotopy head waving duration, day 70.10.10.30.1-0.20.20.30.30.3-0.3-0.60.1
Locomotion velocity, session 82.42.93.11.4-1.71.71.71.71.7-1.7-1.8-1.7
Locomotion distance, session 82.94.25.32.3-2.22.22.22.12.0-1.9-1.9-1.6
Degree of sensitization distance2.12.12.7-1.61.6-1.5-1.6-1.5-1.41.41.40.9
Degree of sensitization stereotypy0.10.10.6-0.30.3-0.3-0.2-0.3-0.30.3-0.00.8
Conditioned locomotion0.00.00.1-0.10.2-0.2-0.2-0.2-0.20.20.3-0.0
Cocaine response after cond. corrected1.61.72.31.2-1.31.31.31.31.3-1.3-1.3-1.5
Cocaine response after cond. not corrected2.02.22.81.6-1.51.51.41.41.4-1.4-1.4-1.7
Cocaine response before conditioning0.20.20.50.7-0.50.50.50.50.4-0.4-0.4-0.2
Saline control response0.81.11.41.2-1.11.11.11.11.0-1.0-1.0-0.7
Bone: connectivity density0.10.10.3-0.40.3-0.3-0.3-0.3-0.40.40.40.6
Bone: cortical apparent density0.20.30.40.3-0.50.50.50.50.6-0.6-0.6-0.6
Bone: cortical area0.20.20.30.3-0.50.50.50.50.5-0.5-0.5-0.5
Bone: cortical porosity0.91.01.2-1.11.1-1.1-1.1-1.0-0.90.90.80.8
Bone: cortical porosity0.91.01.2-1.11.1-1.1-1.1-1.1-0.90.90.90.8
Bone: cortical thickness0.30.50.70.4-0.60.60.60.60.8-0.8-0.8-0.8
Bone: cortical thickness0.91.01.20.9-1.01.01.01.01.0-1.0-1.0-1.1
Bone: cortical tissue density0.20.30.40.4-0.50.50.50.50.6-0.6-0.6-0.6
Condit. Reinf. active minus inactive responses1.11.21.9-0.91.2-1.2-1.1-1.2-1.01.00.91.4
Condit. Reinf. active-inactive response ratio1.31.42.5-1.01.3-1.2-1.2-1.2-1.11.11.01.6
Condit. Reinf. active responses0.10.10.1-0.10.4-0.4-0.3-0.4-0.30.30.20.4
Condit. Reinf. inactive responses1.31.52.41.2-1.21.21.21.21.2-1.2-1.0-1.6
Incentive salience index mean0.91.11.7-0.91.1-1.1-1.1-1.1-1.01.00.91.3
Condit. Reinf. lever presses0.40.50.6-0.60.7-0.7-0.7-0.7-0.70.70.70.8
Condit. Reinf. active minus inactive responses3.13.84.12.0-2.02.02.02.02.0-1.9-2.0-1.6
Condit. Reinf. active-inactive response ratio2.22.32.81.4-1.51.51.61.51.6-1.6-1.7-1.3
Condit. Reinf. active responses1.01.31.71.3-1.21.21.21.21.2-1.1-1.2-0.9
Condit. Reinf. inactive responses0.00.00.20.4-0.20.20.20.20.1-0.1-0.1-0.0
Condit. Reinf. lever presses1.41.92.61.6-1.41.41.41.41.3-1.3-1.3-0.9
Condit. Reinf. lever reinforcers received1.42.02.31.5-1.41.41.41.41.4-1.4-1.4-1.1
Conditioned reinforcement - actives2.32.32.91.7-1.61.61.61.61.5-1.5-1.6-1.0
Conditioned reinforcement - inactives0.40.40.60.8-0.60.60.60.60.6-0.7-0.7-0.4
Conditioned locomotion0.60.70.90.7-0.90.90.90.90.9-0.9-1.0-0.6
Patch foraging indifference point 0 sec4.87.89.83.1-2.82.82.82.82.8-2.8-2.7-2.5
Patch foraging indifference point AUC1.31.52.1-1.41.2-1.2-1.2-1.2-1.31.21.21.1
Delay disc. indifference point, 0s delay0.10.10.3-0.50.3-0.3-0.3-0.3-0.30.30.1-0.0
Delay disc. indifference point, 16s delay0.50.50.80.9-0.80.80.70.70.6-0.6-0.4-0.7
Delay disc. indifference point, 2s delay0.10.10.4-0.4-0.00.00.00.00.1-0.2-0.3-0.6
Delay disc. indifference point, 24s delay0.30.30.80.9-0.60.60.50.50.3-0.3-0.1-0.5
Delay disc. indifference point, 4s delay0.10.10.20.2-0.20.20.20.20.1-0.2-0.2-0.5
Delay disc. indifference point, 8s delay0.00.00.10.1-0.10.00.00.0-0.20.20.4-0.1
Indifference point function ln k4.46.17.82.8-2.52.52.52.52.5-2.5-2.5-1.9
Indifference point function log k4.46.17.82.8-2.52.52.52.52.5-2.5-2.5-1.9
Patch foraging total patch changes 0 sec5.99.511.23.3-3.13.13.13.13.1-3.1-3.0-2.8
Patch foraging total patch changes 12 sec0.00.00.0-0.20.1-0.1-0.1-0.1-0.20.20.20.1
Patch foraging total patch changes 18 sec0.00.00.10.2-0.10.10.10.10.1-0.1-0.10.1
Patch foraging total patch changes 24 sec0.80.91.01.0-1.01.01.01.01.0-1.0-0.9-1.0
Patch foraging total patch changes 6 sec1.01.51.81.1-1.21.21.21.21.2-1.2-1.2-1.3
Patch foraging time to switch 0 sec6.39.710.0-3.03.1-3.1-3.1-3.1-3.23.23.13.1
Patch foraging water rate 0 sec5.58.89.42.9-3.03.03.03.03.0-3.0-3.1-2.8
Patch foraging water rate 12 sec5.78.89.62.9-2.92.92.92.93.0-3.0-2.9-3.1
Patch foraging water rate 18 sec6.28.38.52.8-2.92.92.92.92.9-2.9-2.9-2.8
Patch foraging water rate 24 sec3.34.65.51.8-2.12.12.12.12.2-2.2-2.3-2.2
Patch foraging water rate 6 sec13.820.120.54.4-4.54.54.54.54.5-4.5-4.5-4.4
Seeking ratio, delayed vs. immediate footshock1.41.62.4-1.61.2-1.2-1.2-1.2-1.21.21.11.2
Distance traveled before self-admin2.22.32.81.7-1.51.51.51.51.5-1.5-1.3-1.7
Distance traveled after self-admin1.51.72.11.0-1.31.31.31.31.3-1.3-1.2-1.5
Extensor digitorum longus weight3.814.816.9-4.13.9-3.9-3.9-3.9-3.83.83.63.9
Bone: elastic displacement1.21.31.5-1.01.2-1.2-1.2-1.2-1.21.21.20.9
Bone: elastic work0.70.91.1-0.60.9-1.0-1.0-1.0-1.01.01.00.9
Bone: endosteal estimation0.10.30.70.8-0.60.50.50.50.4-0.4-0.3-0.2
Bone: endosteal perimeter0.00.10.3-0.10.2-0.2-0.2-0.2-0.30.30.40.5
Epididymis fat weight0.00.00.00.00.0-0.00.0-0.00.1-0.1-0.20.0
Delta time in closed arm before/after self-admin5.25.16.7-2.02.1-2.2-2.2-2.2-2.32.32.42.6
Delta time in open arm before/after self-admin0.00.00.10.00.1-0.1-0.1-0.1-0.10.10.1-0.3
Diff in mean of infusions in LGA sessions0.20.20.4-0.70.5-0.5-0.5-0.5-0.40.40.50.2
Delay discount exponential model param0.30.30.5-0.50.6-0.6-0.5-0.5-0.40.40.30.7
Extinction: sum of active levers before priming1.81.82.6-0.91.3-1.3-1.3-1.4-1.41.41.61.4
Active lever presses in extinction session 62.12.12.6-1.51.4-1.5-1.5-1.5-1.41.41.61.0
Bone: final force0.50.81.31.1-0.90.90.90.90.8-0.8-0.8-0.5
Bone: final moment0.71.11.71.3-1.11.11.11.11.0-1.0-1.0-0.7
Food consumed during 24 hour testing period0.91.11.41.1-1.11.11.11.11.1-1.1-1.2-0.8
Glucose0.30.50.9-1.00.8-0.8-0.8-0.7-0.50.50.60.1
Heart weight0.50.61.3-0.50.8-0.8-0.8-0.8-0.80.80.71.2
Delay discount hyperbolic model param0.20.30.6-0.40.5-0.5-0.5-0.5-0.40.40.30.8
Intermittent access intake day 1-15 change0.20.20.30.4-0.30.30.40.30.5-0.5-0.6-0.6
Intermittent access intake escalation0.40.40.70.5-0.50.50.60.50.7-0.7-0.8-0.9
Intermittent access intake escalation 20.00.00.0-0.00.0-0.0-0.0-0.00.0-0.1-0.20.0
Intermitt. access day 1 inactive lever presses2.52.73.2-1.51.7-1.7-1.6-1.7-1.61.61.61.8
Intermitt. access day 15 inactive lever presses2.73.03.7-1.71.8-1.8-1.8-1.8-1.71.71.91.5
Intermitt. access escalation Index0.10.10.10.4-0.30.30.30.30.3-0.3-0.2-0.4
Intermittent access day 1 total infusions0.91.01.61.3-1.01.01.01.01.0-1.0-0.9-0.9
Intermittent access day 15 total infusions2.32.63.41.8-1.51.51.51.51.6-1.7-1.6-1.6
Intermittent access terminal intake (last 3 days)1.01.11.61.3-1.01.01.01.01.0-1.0-1.0-1.0
Intermittent access total infusions2.42.63.51.9-1.61.61.61.61.6-1.6-1.6-1.5
Intermittent access day 1 locomotion2.72.83.21.8-1.61.61.71.71.7-1.7-1.7-1.6
Intermittent access day 15 total locomotion2.83.03.61.6-1.61.71.71.71.8-1.8-1.8-1.9
Intermittent access total locomotion5.46.26.52.5-2.42.52.52.52.6-2.6-2.5-2.4
Intermittent access standard deviation0.40.50.5-0.70.7-0.7-0.7-0.7-0.70.70.50.7
Left kidney weight0.92.53.01.7-1.61.61.61.61.6-1.6-1.7-1.2
Right kidney weight0.20.60.70.8-0.80.80.80.80.8-0.8-0.8-0.6
Cocaine induced anxiety0.60.60.91.0-0.90.90.80.80.7-0.7-0.5-0.8
Post-drug Anxiety0.91.01.30.9-1.11.11.11.11.0-1.0-0.8-1.0
Baseline Anxiety0.00.00.0-0.1-0.10.10.10.10.1-0.1-0.10.1
Tail length8.425.325.84.9-5.15.15.15.15.0-5.1-5.1-4.9
Length with tail12.144.345.46.6-6.76.76.76.76.7-6.7-6.5-6.4
Length without tail7.115.616.24.0-4.04.04.04.04.0-4.0-3.8-3.7
Times rat made contact with spout0.40.50.7-0.60.7-0.7-0.7-0.7-0.70.70.60.9
Lifetime Intake2.22.53.31.8-1.51.51.51.51.6-1.6-1.5-1.5
Liver weight, left1.21.93.60.7-1.11.21.21.21.5-1.5-1.6-1.9
Liver weight, right0.00.10.1-0.30.3-0.3-0.3-0.3-0.30.30.3-0.0
Locomotor activity0.10.20.50.7-0.50.50.50.50.3-0.3-0.40.1
Locomotor testing distance0.50.91.7-0.50.8-0.9-0.9-0.9-1.01.01.01.3
Locomotor testing rearing0.30.50.6-0.40.7-0.7-0.7-0.7-0.80.80.80.8
Locomotion in novel chamber1.62.03.0-1.31.3-1.3-1.3-1.3-1.41.41.51.7
Locomotion in novel chamber post-restriction0.20.30.8-0.40.4-0.4-0.4-0.4-0.50.60.60.9
Fecal boli incidents, locomotor time 12.72.94.0-1.21.7-1.7-1.7-1.7-1.81.81.72.0
Change in fecal boli incidents, locomotor task0.10.10.4-0.6-0.10.10.10.10.2-0.2-0.0-0.4
Time >=10cm from walls, locomotor time 11.61.61.9-1.21.3-1.3-1.3-1.3-1.21.21.21.4
Bouts of movement, locomotor time 10.60.60.9-0.50.8-0.8-0.8-0.8-0.90.80.71.0
Total resting periods, locomotor time 10.30.30.7-0.10.5-0.5-0.5-0.5-0.60.60.50.9
Rest time, locomotor task time 12.42.64.0-1.31.6-1.6-1.6-1.6-1.61.71.52.0
Distance moved, locomotor task time 12.52.73.11.2-1.61.61.61.71.8-1.8-1.6-1.8
Vertical activity count, locomotor time 12.32.44.30.6-1.51.51.51.51.6-1.7-1.6-2.1
Time >=10cm from walls, locomotor time 21.01.11.6-0.91.0-1.0-1.0-1.0-1.01.11.11.2
Bouts of movement, locomotor time 20.00.00.10.3-0.20.20.20.20.1-0.1-0.10.0
Total resting periods, locomotor time 20.10.10.2-0.10.3-0.3-0.3-0.3-0.40.40.30.5
Rest time, locomotor task time 23.94.45.2-1.62.2-2.2-2.1-2.2-2.12.12.02.3
Distance moved, locomotor task time 22.02.42.61.1-1.61.61.61.61.6-1.6-1.5-1.5
Vertical activity count, locomotor time 21.01.11.90.2-1.01.01.01.01.1-1.1-1.4-1.3
Light reinforcement 12.54.55.52.1-2.12.12.12.12.1-2.1-2.3-1.9
Light reinforcement 20.10.10.2-0.30.4-0.4-0.4-0.4-0.40.40.20.4
Bone: marrow area0.10.20.70.8-0.50.50.50.50.4-0.4-0.3-0.2
Bone: maximum diameter0.40.80.9-1.00.9-0.9-0.9-0.9-0.90.90.90.9
Bone: maximum force0.10.10.30.6-0.30.30.30.30.2-0.2-0.20.1
Bone: maximum moment0.20.30.60.8-0.60.50.60.50.5-0.4-0.4-0.1
Mean time between licks in bursts0.00.10.1-0.30.2-0.2-0.2-0.2-0.20.20.3-0.0
Mean num. licks in bursts2.22.72.91.6-1.61.61.61.61.6-1.6-1.7-1.6
Cd content in liver0.50.50.70.5-0.70.70.70.80.7-0.7-0.7-0.9
Co content in liver0.10.10.30.6-0.30.30.30.30.2-0.2-0.0-0.2
Cu content in liver0.40.40.60.7-0.60.60.60.60.7-0.7-0.7-0.6
Fe content in liver1.82.22.41.3-1.41.41.51.51.5-1.5-1.6-1.5
K content in liver1.41.41.91.1-1.41.31.31.31.1-1.1-1.1-0.7
Mg content in liver0.10.10.10.2-0.40.30.30.30.1-0.1-0.10.2
Mn content in liver0.30.40.50.6-0.60.60.60.60.7-0.6-0.7-0.5
Na content in liver0.20.20.30.6-0.50.40.40.40.4-0.4-0.4-0.2
Rb content in liver1.01.21.71.3-1.11.11.11.11.1-1.1-1.0-1.1
Se content in liver0.10.20.4-0.60.4-0.4-0.4-0.4-0.30.30.30.4
Sr content in liver3.22.93.6-1.51.6-1.7-1.7-1.7-1.81.81.91.8
Zn content in liver0.00.00.2-0.10.1-0.1-0.1-0.1-0.20.20.20.4
Bone: minimum diameter1.93.53.61.9-1.91.91.91.91.9-1.9-1.8-1.8
Time in familiar zone, hab. session 14.24.04.41.9-2.02.02.02.02.0-2.0-2.1-1.8
Time in novel zone, hab. session 15.75.56.0-2.42.4-2.4-2.4-2.4-2.42.32.51.9
Total zone transitions, hab. session 10.00.00.3-0.10.0-0.0-0.0-0.0-0.10.10.00.6
Total locomotion distance, hab. session 10.00.10.4-0.00.0-0.1-0.1-0.1-0.20.30.20.7
Locomotion velocity, hab. session 10.00.10.4-0.00.0-0.0-0.0-0.1-0.20.20.10.6
Time in familiar zone, hab. session 21.51.51.61.2-1.21.21.21.21.2-1.2-1.3-1.2
Time in novel zone, hab. session 22.02.02.3-1.41.4-1.4-1.4-1.4-1.41.41.41.5
Total zone transitions, hab. session 20.10.10.20.2-0.30.30.30.30.3-0.3-0.4-0.1
Total locomotion distance, hab. session 20.20.20.6-0.30.3-0.4-0.4-0.4-0.50.50.40.8
Locomotion velocity, hab. session 20.00.00.10.1-0.00.00.00.0-0.10.10.00.3
Novel to familiar place preference ratio1.92.02.1-1.41.4-1.4-1.5-1.5-1.41.41.41.2
Novelty place preference1.41.41.5-1.21.2-1.2-1.2-1.2-1.21.21.21.0
Time in novel zone, NPP test1.51.51.6-1.31.3-1.3-1.3-1.3-1.21.21.21.0
Total zone transitions, NPP test1.21.72.01.3-1.41.41.41.41.3-1.3-1.4-1.0
Total locomotion distance, NPP test0.00.00.10.3-0.20.20.20.20.1-0.0-0.10.3
Locomotion velocity, NPP test0.40.50.70.8-0.80.80.80.70.7-0.7-0.7-0.4
Intraocular pressure2.73.74.4-1.72.1-2.1-2.0-2.1-1.81.81.71.9
Delta distance traveled before/after self-admin0.30.30.50.3-0.60.60.60.60.6-0.6-0.7-0.5
Delta ambulatory time before/after self-admin0.30.30.40.4-0.60.60.60.60.6-0.6-0.7-0.5
Parametrial fat weight0.00.00.3-0.2-0.00.10.00.10.1-0.2-0.1-0.5
Pavlov. Cond. lever latency0.00.00.1-0.30.1-0.1-0.1-0.1-0.00.0-0.0-0.2
Pavlov. Cond. magazine entry latency1.62.12.41.5-1.61.51.51.51.4-1.4-1.2-1.6
Pavlov. Cond. change in total contacts2.62.83.41.8-1.81.71.71.71.6-1.6-1.6-1.3
Pavlov. Cond. index score0.30.40.70.8-0.70.70.70.70.5-0.5-0.4-0.5
Pavlov. Cond. latency score0.10.10.20.5-0.30.30.30.30.2-0.2-0.1-0.1
Pavlov. Cond. lever contacts0.30.30.50.7-0.60.60.60.60.5-0.5-0.4-0.4
Pavlov. Cond. magazine entry number1.41.82.6-1.61.5-1.5-1.4-1.4-1.21.21.01.2
Pavlov. Cond. intertrial magazine entries4.25.15.6-2.32.4-2.4-2.3-2.3-2.22.22.12.1
Pavlov. Cond. lever-magazine prob. diff.0.50.61.01.0-0.90.80.80.80.7-0.7-0.6-0.7
Pavlov. Cond. response bias1.62.02.61.6-1.51.51.51.51.3-1.3-1.2-1.3
Pavlov. Cond. lever latency1.31.72.6-1.61.4-1.4-1.4-1.4-1.31.21.30.7
Pavlov. Cond. magazine entry latency0.50.61.01.0-0.90.90.80.90.7-0.7-0.6-0.6
Pavlov. Cond. change in total contacts4.15.66.52.5-2.52.52.52.52.3-2.3-2.3-1.8
Pavlov. Cond. index score1.82.33.21.8-1.61.61.61.61.5-1.4-1.4-1.1
Pavlov. Cond. latency score1.92.43.31.8-1.61.61.61.61.5-1.4-1.4-1.1
Pavlov. Cond. lever contacts1.52.03.01.7-1.51.51.51.51.4-1.4-1.4-0.9
Pavlov. Cond. magazine entry number1.11.31.7-1.31.3-1.3-1.2-1.2-1.11.11.00.8
Pavlov. Cond. intertrial magazine entries0.30.41.10.5-0.40.40.50.50.6-0.6-0.6-1.0
Pavlov. Cond. lever-magazine prob. diff.1.92.53.41.8-1.71.71.71.61.5-1.5-1.4-1.2
Pavlov. Cond. response bias1.21.62.31.5-1.31.31.31.31.2-1.2-1.2-0.8
Time in closed arm before self-admin0.10.10.3-0.1-0.20.20.20.20.2-0.2-0.3-0.5
Time in closed arm after self-admin0.70.71.0-1.00.8-0.8-0.8-0.8-0.90.80.90.9
Time in open arm before self-admin0.10.10.30.5-0.30.30.20.30.2-0.2-0.1-0.1
Time in open arm after self-admin0.20.20.3-0.40.5-0.5-0.5-0.5-0.50.50.50.4
Bone: periosteal estimation0.10.30.40.6-0.50.50.50.50.5-0.5-0.5-0.4
Bone: periosteal perimeter0.00.00.10.3-0.20.10.10.10.1-0.10.10.0
Bone: post-yield work0.00.00.1-0.10.1-0.1-0.0-0.0-0.00.0-0.10.4
Progressive ratio test 1 active lever presses1.11.11.61.3-1.01.01.01.01.1-1.1-0.9-1.1
Progressive ratio test 1 breakpoint1.11.21.81.3-1.11.11.11.11.1-1.1-0.9-1.1
Progressive ratio test 1 inactive lever presses0.60.71.01.0-0.80.80.80.80.8-0.8-0.7-0.9
Progressive ratio test 2 active lever presses0.30.30.60.8-0.50.50.60.50.6-0.6-0.6-0.4
Progressive ratio test 2 breakpoint0.20.20.50.7-0.40.40.50.40.5-0.5-0.5-0.3
Progressive ratio test 2 inactive lever presses0.30.30.50.7-0.50.50.50.50.6-0.6-0.6-0.6
Incentive Sensitization - Responses0.50.50.70.9-0.70.70.80.70.7-0.7-0.8-0.4
Incentive Sensitization - Breakpoint0.30.30.50.7-0.60.60.60.60.6-0.6-0.7-0.3
Sum of active levers in priming session hrs 5-60.60.60.7-0.80.8-0.8-0.9-0.8-0.70.70.90.2
Progressive ratio0.00.00.0-0.10.1-0.1-0.1-0.1-0.10.10.20.2
Food seeking constrained by brief footshock2.53.14.11.7-1.81.81.71.81.7-1.7-1.5-2.0
Seeking ratio, punishment vs. effort0.91.22.01.0-1.01.01.01.01.0-1.1-1.1-1.4
Retroperitoneal fat weight0.41.31.9-1.41.3-1.3-1.2-1.2-1.11.01.00.6
Reaction time number correct9.213.314.23.6-3.63.63.63.63.6-3.6-3.6-3.8
Reaction time mean minus median0.00.00.00.2-0.20.20.20.20.1-0.1-0.10.1
Reaction time mean minus median AUC0.30.30.40.6-0.60.60.60.60.6-0.6-0.6-0.3
Reaction time num false alarms0.50.71.2-0.80.9-0.9-0.8-0.9-0.80.80.81.1
Reaction time num false alarms AUC1.01.42.3-1.11.2-1.2-1.1-1.2-1.11.11.01.5
Reaction time trials correct on left9.213.314.23.6-3.63.63.63.63.6-3.6-3.6-3.8
Reaction time trials on left9.513.614.63.7-3.73.73.73.73.7-3.7-3.6-3.8
Reaction time mean1.82.53.1-1.61.5-1.5-1.5-1.5-1.61.61.51.8
Reaction time mean AUC1.62.22.6-1.51.4-1.4-1.4-1.4-1.51.51.41.6
Median of all reaction times2.94.04.5-2.12.0-2.0-2.0-2.0-2.02.01.92.1
Reaction time omissions0.30.40.60.4-0.50.60.60.60.7-0.7-0.7-0.8
Reaction time false alarm rate6.08.310.5-2.82.9-2.9-2.8-2.9-2.82.92.73.2
Reaction time premature initiation rate3.04.04.52.0-2.12.12.12.12.0-2.0-2.0-1.6
Reaction time premature initiations10.114.315.13.8-3.93.93.93.93.7-3.7-3.7-3.5
Std. dev. reaction times0.10.10.4-0.50.3-0.3-0.3-0.3-0.30.40.30.6
Reaction time trials completed9.513.614.63.7-3.73.73.73.73.7-3.7-3.6-3.8
Reaction time trials AUC8.612.413.13.5-3.53.53.53.53.5-3.5-3.5-3.6
Run reversals in cocaine runway, females0.60.61.4-1.20.7-0.7-0.7-0.7-0.70.70.80.5
Run reversals in cocaine runway, males0.10.10.3-0.10.2-0.3-0.3-0.3-0.50.50.50.5
Latency to leave start box in cocaine runway3.13.35.2-1.81.8-1.8-1.7-1.8-1.81.91.52.3
Latency to leave start box in cocaine runway, F0.50.51.3-0.70.7-0.7-0.7-0.7-0.70.70.41.1
Latency to leave start box in cocaine runway, M3.53.34.6-1.91.8-1.8-1.7-1.8-1.81.81.72.1
Std. dev. time between licks in bursts1.01.21.5-1.21.1-1.1-1.1-1.1-1.11.11.20.8
Total sessions with >9 infusions0.70.81.21.1-0.90.90.90.90.9-0.9-0.8-0.8
Short access day 1 total inactive lever presses0.10.10.30.3-0.30.30.30.30.4-0.4-0.4-0.6
Short access day 10 total inactive lever presses0.70.81.0-0.80.8-0.8-0.8-0.8-0.90.91.01.0
Short access day 1 total infusions1.51.62.51.6-1.21.21.21.21.2-1.3-1.2-1.3
Short access day 10 total infusions1.41.52.21.5-1.21.21.21.21.2-1.2-1.1-1.1
Short access total infusions2.02.22.81.7-1.51.51.51.51.5-1.5-1.4-1.5
Short access day 1 locomotion0.40.50.70.8-0.60.60.70.70.7-0.7-0.7-0.6
Short access day 10 total locomotion0.00.00.00.2-0.10.10.10.10.2-0.2-0.2-0.2
Short access total locomotion2.12.22.51.4-1.41.41.51.51.6-1.6-1.6-1.4
One hour access (0.3 mA shock)1.21.41.91.1-1.11.21.21.21.2-1.3-1.4-1.2
Compulsive drug intake0.20.20.4-0.70.4-0.4-0.4-0.4-0.40.40.30.5
One hour access (shock baseline)2.42.73.31.8-1.61.61.61.61.6-1.7-1.7-1.7
Social response proportion0.10.10.1-0.10.2-0.2-0.2-0.2-0.20.20.30.2
Social responses0.91.11.41.1-1.21.21.11.11.0-1.0-0.9-0.9
Social time0.00.10.30.3-0.10.10.10.10.2-0.2-0.1-0.6
Soleus weight0.10.20.3-0.40.5-0.5-0.5-0.5-0.40.30.40.1
Bone: stiffness0.20.20.60.8-0.60.50.50.50.4-0.4-0.4-0.1
Tibialis anterior weight2.37.89.1-3.02.8-2.8-2.8-2.8-2.72.72.62.8
Time to tail flick, vehicle, before self-admin4.44.55.02.2-2.12.12.22.12.1-2.1-2.2-1.8
Time to tail flick, vehicle, after self-admin1.21.32.21.5-1.31.21.21.21.1-1.0-1.0-0.6
Time to tail flick, test, before self-admin0.20.20.30.5-0.40.40.40.40.4-0.4-0.6-0.3
Time to tail flick, test, after self-admin0.20.21.0-1.00.5-0.5-0.5-0.5-0.30.20.1-0.0
Delta time to tail flick, vehicle, before/after SA1.41.41.9-1.01.1-1.1-1.1-1.1-1.21.21.31.4
Delta time to tail flick, test, before/after SA0.10.10.4-0.70.2-0.2-0.2-0.1-0.10.10.1-0.1
Tibia length6.718.919.84.5-4.34.34.34.34.4-4.4-4.5-4.2
Ambulatory time before self-admin0.70.81.01.0-0.90.90.90.90.9-0.9-0.7-0.9
Ambulatory time after self-admin0.80.91.40.7-1.01.01.01.00.9-0.9-0.8-1.2
Bone: tissue strength1.01.01.3-0.91.0-1.0-1.0-1.0-1.01.01.01.2
Total heroin consumption1.01.11.5-1.21.1-1.1-1.1-1.1-1.01.01.20.5
Bone: trabecular number0.10.10.3-0.20.2-0.2-0.2-0.2-0.30.30.30.5
Bone: trabecular spacing0.10.10.5-0.3-0.00.10.10.10.3-0.3-0.4-0.7
Bone: trabecular thickness1.51.82.4-1.11.2-1.3-1.3-1.3-1.41.41.41.6
Bone: trabecular tissue density2.33.23.4-1.91.8-1.8-1.8-1.8-1.81.81.71.7
Water consumed over 24 hours0.80.91.8-0.80.9-0.9-0.9-0.9-0.91.00.81.3
Number of responses in last shaping day0.30.30.4-0.30.6-0.6-0.6-0.6-0.50.50.60.4