Hub : Genes

Srebf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Srebf2 0.08 0.06 6.6e-03 0.02 0.03 0.04 0.03 3.5e-02 2.2e-02 8.8e-03 2.1e-02
2 Adipose gene expression Srebf2 0.07 0.04 1.6e-05 0.02 0.03 0.02 0.02 1.3e-03 6.5e-04 3.1e-03 2.5e-03
3 Brain mRNA stability Srebf2 0.09 0.04 3.5e-10 0.08 0.09 0.08 0.08 4.3e-08 1.5e-08 8.1e-08 4.1e-08
4 PL mRNA stability Srebf2 0.06 0.03 2.2e-04 0.04 0.03 0.03 0.03 5.0e-05 2.6e-04 1.9e-04 1.5e-04
5 Eye gene expression Srebf2 0.81 0.14 3.0e-07 0.35 0.25 0.29 0.32 2.0e-06 1.1e-04 2.1e-05 6.8e-06
6 Liver mRNA stability Srebf2 0.04 0.02 3.4e-05 0.01 0.02 0.02 0.01 8.9e-03 2.2e-03 3.2e-03 8.3e-03
7 BLA gene expression Srebf2 0.41 0.12 2.5e-14 0.22 0.22 0.25 0.26 3.8e-12 5.2e-12 2.2e-13 3.8e-14
8 PL gene expression Srebf2 0.34 0.1 0.0e+00 0.25 0.26 0.28 0.28 4.3e-27 6.0e-29 7.6e-31 6.2e-31
9 pVTA gene expression Srebf2 0.45 0.15 2.4e-08 0.19 0.19 0.2 0.18 1.5e-08 1.5e-08 6.8e-09 4.3e-08
10 IL gene expression Srebf2 0.29 0.14 2.3e-03 0.03 0.09 0.06 0.03 7.9e-02 4.0e-03 1.8e-02 5.9e-02
11 Brain gene expression Srebf2 0.06 0.03 4.0e-05 0.04 0.03 0.03 0.03 2.2e-04 5.0e-04 5.6e-04 4.8e-04
12 OFC gene expression Srebf2 0.18 0.1 6.8e-03 0.12 0.07 0.06 0.1 8.8e-04 1.1e-02 1.2e-02 2.8e-03
13 LHb gene expression Srebf2 0.27 0.13 2.6e-03 0.05 0.09 0.11 0.11 2.4e-02 3.5e-03 1.2e-03 1.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.30.9-0.7-0.70.9-0.70.20.50.2-0.20.40.3-0.4-0.20.3
Area under the delay curve0.20.20.7-0.8-0.60.4-0.80.80.40.40.6-0.30.20.1-0.2-0.1
BMI with tail0.92.86.41.71.7-2.21.2-0.3-2.51.41.6-2.51.1-1.3-0.9-2.0
BMI without tail0.10.20.50.70.6-0.40.70.2-0.2-0.00.1-0.40.10.30.6-0.5
Body weight0.83.19.63.12.5-2.72.1-1.9-2.4-0.30.1-1.2-0.1-1.0-0.6-1.1
Weight adjusted by age1.01.12.30.80.7-0.31.4-1.00.5-1.5-1.41.3-1.41.00.80.9
Bone surface0.50.82.10.2-0.20.60.2-0.80.5-1.4-1.21.4-1.0-0.20.81.5
Bone volume0.20.30.80.20.00.30.1-0.60.3-0.8-0.70.7-0.6-0.20.40.9
Breakpoint value in progressive ratio session0.40.40.9-0.4-0.50.4-0.60.8-0.20.70.7-0.60.9-0.6-0.8-0.7
Number of licking bursts0.20.20.8-0.9-0.70.6-0.40.60.6-0.2-0.10.4-0.10.10.40.2
Context. condit. distance diff. score3.44.110.93.23.2-3.32.7-2.6-2.2-0.8-0.7-0.5-1.00.1-0.5-0.6
Locomotion velocity, session 11.31.43.50.50.4-0.10.7-1.30.3-1.9-1.51.5-1.70.41.31.7
Locomotion distance, session 11.31.73.7-1.8-1.41.6-0.70.21.9-0.9-0.81.5-1.11.11.41.6
Locomotion velocity, session 20.40.41.30.90.8-0.50.6-0.6-0.3-0.9-0.1-0.2-0.8-0.00.61.1
Locomotion distance, session 21.82.67.7-2.8-2.62.3-2.21.91.21.11.1-0.10.9-0.7-0.20.3
Locomotion velocity, session 31.11.32.60.91.0-0.60.9-1.20.2-1.3-1.30.7-1.61.31.11.5
Locomotion distance, session 31.11.22.7-1.0-0.50.70.0-0.11.6-0.9-1.01.2-1.31.61.41.0
Stereotopy head waving bouts, day 30.40.51.91.40.9-0.70.7-1.0-0.9-0.6-0.50.0-0.5-0.4-0.20.6
Stereotopy head waving duration, day 32.22.79.23.02.3-2.01.8-2.1-1.7-1.5-1.10.1-1.1-0.5-0.01.0
Locomotion velocity, session 70.30.30.60.40.6-0.50.3-0.30.1-0.40.0-0.6-0.80.60.80.8
Locomotion distance, session 70.70.92.3-1.1-0.80.5-1.11.10.21.31.5-1.50.7-0.2-0.4-0.4
Stereotopy head waving bouts, day 74.55.010.33.02.6-1.92.4-3.2-0.9-2.7-2.61.7-2.30.81.12.1
Stereotopy head waving duration, day 73.64.38.62.92.5-1.82.3-2.8-0.6-2.5-2.41.5-2.11.01.31.7
Locomotion velocity, session 81.21.43.51.51.5-1.91.5-1.2-1.8-0.3-0.2-0.3-0.2-1.3-1.0-0.5
Locomotion distance, session 80.50.71.91.21.4-1.31.2-1.0-0.8-0.4-0.40.1-0.70.1-0.20.1
Degree of sensitization distance2.62.66.11.00.7-1.1-0.20.6-2.11.82.0-2.51.7-1.8-1.9-1.7
Degree of sensitization stereotypy3.74.18.92.52.2-1.72.1-3.0-0.5-2.5-2.41.8-2.21.11.21.7
Conditioned locomotion0.91.02.31.11.5-1.21.3-1.3-0.2-0.6-1.00.5-1.11.20.40.2
Cocaine response after cond. corrected0.10.10.40.40.4-0.30.5-0.10.1-0.4-0.20.0-0.50.60.60.1
Cocaine response after cond. not corrected0.20.30.60.40.5-0.30.6-0.10.2-0.6-0.40.3-0.70.70.80.6
Cocaine response before conditioning0.10.10.8-0.0-0.00.1-0.20.30.3-0.1-0.00.2-0.10.20.20.9
Saline control response1.31.74.11.11.1-0.71.4-1.20.3-1.6-2.01.8-1.50.71.01.0
Bone: connectivity density0.10.20.5-0.4-0.60.7-0.60.10.20.1-0.20.30.3-0.5-0.30.2
Bone: cortical apparent density0.40.51.7-1.3-1.11.1-1.10.50.70.40.10.30.20.10.00.4
Bone: cortical area0.71.12.91.71.5-1.61.0-1.5-1.5-0.30.0-0.6-0.2-0.8-0.3-0.0
Bone: cortical porosity0.40.41.31.21.1-0.80.5-0.5-0.5-0.4-0.60.1-0.30.30.10.8
Bone: cortical porosity0.70.82.71.71.4-1.20.9-0.9-1.0-0.5-0.6-0.1-0.40.10.00.6
Bone: cortical thickness1.01.63.2-0.5-0.4-0.3-0.80.6-1.21.71.8-1.81.7-1.5-1.4-1.4
Bone: cortical thickness1.41.63.8-0.3-0.2-0.6-0.30.9-1.11.51.6-1.71.5-1.6-1.4-2.0
Bone: cortical tissue density0.40.51.8-1.3-1.11.1-1.10.50.70.40.10.30.20.0-0.00.4
Condit. Reinf. active minus inactive responses0.50.61.8-0.8-1.00.8-1.30.70.00.81.1-0.80.6-0.4-0.40.5
Condit. Reinf. active-inactive response ratio0.10.10.50.60.3-0.3-0.1-0.5-0.5-0.20.1-0.4-0.2-0.0-0.00.7
Condit. Reinf. active responses1.21.43.4-1.6-1.61.6-1.81.70.80.91.3-0.50.9-0.2-0.20.5
Condit. Reinf. inactive responses1.41.74.5-2.0-1.81.9-1.72.11.50.70.80.10.80.10.20.1
Incentive salience index mean1.01.33.4-1.3-1.41.1-1.81.30.21.11.5-1.00.9-0.6-0.60.5
Condit. Reinf. lever presses0.81.13.1-1.2-1.21.2-1.81.40.70.61.3-0.70.5-0.3-0.11.1
Condit. Reinf. active minus inactive responses0.70.91.7-1.0-1.00.4-1.20.5-0.71.21.1-0.71.0-1.3-1.3-0.0
Condit. Reinf. active-inactive response ratio1.21.32.7-0.7-1.00.5-1.40.7-1.01.41.4-1.11.3-1.6-1.5-0.2
Condit. Reinf. active responses0.20.31.20.20.1-0.5-0.1-0.6-1.10.20.4-0.40.1-1.1-0.90.3
Condit. Reinf. inactive responses0.60.71.71.11.2-1.31.1-1.2-0.8-0.7-0.2-0.1-0.9-0.00.10.4
Condit. Reinf. lever presses0.50.71.8-0.9-1.21.0-1.40.8-0.00.60.40.20.7-0.8-0.70.8
Condit. Reinf. lever reinforcers received0.20.31.2-0.1-0.2-0.1-0.5-0.3-0.90.40.5-0.30.3-1.1-1.00.5
Conditioned reinforcement - actives0.20.20.6-0.20.6-0.80.7-0.8-0.4-0.2-0.1-0.1-0.60.30.20.0
Conditioned reinforcement - inactives0.60.61.2-0.7-0.80.4-0.90.7-0.40.61.1-0.61.0-0.9-1.1-0.8
Conditioned locomotion0.91.12.71.01.1-1.50.8-0.5-1.60.60.9-1.50.2-0.8-0.9-0.9
Patch foraging indifference point 0 sec0.40.71.5-0.7-1.21.1-1.21.00.10.40.20.31.0-1.2-0.50.0
Patch foraging indifference point AUC0.10.10.6-0.6-0.70.5-0.30.20.3-0.1-0.00.2-0.2-0.20.60.2
Delay disc. indifference point, 0s delay0.50.61.10.91.0-1.00.60.1-1.00.50.8-1.00.4-0.4-1.0-0.4
Delay disc. indifference point, 16s delay0.90.92.3-1.3-1.51.4-1.40.91.20.1-0.10.60.20.40.50.2
Delay disc. indifference point, 2s delay0.20.21.1-0.20.2-0.4-0.10.5-0.20.60.8-1.00.20.1-0.4-0.3
Delay disc. indifference point, 24s delay0.40.41.0-0.4-0.30.30.1-0.70.7-0.9-0.80.7-1.00.60.90.6
Delay disc. indifference point, 4s delay0.80.81.5-0.7-0.80.3-0.91.0-0.61.01.2-0.91.1-1.2-1.0-0.9
Delay disc. indifference point, 8s delay0.50.61.7-1.3-1.00.9-1.11.00.90.50.5-0.10.20.50.10.2
Indifference point function ln k0.60.82.01.41.3-1.21.0-1.2-1.0-0.2-0.2-0.3-0.1-0.4-1.0-0.4
Indifference point function log k0.60.82.01.41.3-1.21.0-1.2-1.0-0.2-0.2-0.3-0.1-0.4-1.0-0.4
Patch foraging total patch changes 0 sec0.40.71.6-0.8-1.31.2-1.31.00.30.40.10.51.0-1.1-0.4-0.1
Patch foraging total patch changes 12 sec0.20.31.3-0.1-0.70.5-0.70.6-0.40.40.3-0.20.5-1.10.10.2
Patch foraging total patch changes 18 sec0.50.61.6-0.7-1.00.7-1.20.5-0.30.70.6-0.11.0-1.3-0.7-0.2
Patch foraging total patch changes 24 sec0.20.20.5-0.2-0.70.7-0.60.40.4-0.2-0.20.30.1-0.20.60.3
Patch foraging total patch changes 6 sec0.40.61.7-0.6-1.20.8-0.71.3-0.20.20.40.00.8-1.30.3-0.5
Patch foraging time to switch 0 sec0.20.42.60.40.30.3-0.4-0.00.4-0.3-0.30.1-0.40.90.71.6
Patch foraging water rate 0 sec0.40.72.4-0.7-0.90.4-0.10.9-0.30.60.40.01.0-1.4-0.7-1.5
Patch foraging water rate 12 sec0.10.20.7-0.2-0.60.7-0.00.10.5-0.3-0.60.8-0.0-0.20.4-0.2
Patch foraging water rate 18 sec0.50.72.3-0.9-1.41.5-0.60.81.0-0.4-0.61.1-0.0-0.10.10.5
Patch foraging water rate 24 sec0.20.21.4-0.1-0.40.2-0.10.1-0.70.40.3-0.20.7-1.2-0.1-0.5
Patch foraging water rate 6 sec0.81.23.2-0.4-0.61.1-0.1-0.11.2-1.4-1.41.8-1.00.71.21.2
Seeking ratio, delayed vs. immediate footshock2.32.66.9-2.5-2.32.4-2.62.01.61.10.50.31.00.30.60.5
Distance traveled before self-admin1.71.84.3-1.3-0.80.3-1.41.6-0.62.11.9-1.51.7-0.9-1.0-1.1
Distance traveled after self-admin0.50.51.7-0.3-0.40.1-0.60.2-0.80.80.7-0.41.1-1.3-0.7-0.9
Extensor digitorum longus weight0.10.30.8-0.4-0.30.50.10.60.7-0.4-0.60.9-0.00.80.7-0.0
Bone: elastic displacement1.01.13.51.10.8-0.51.4-1.20.1-1.9-1.41.0-1.20.31.10.5
Bone: elastic work1.21.65.62.41.6-1.61.5-1.4-1.7-0.9-0.2-0.6-0.1-1.0-0.4-0.3
Bone: endosteal estimation2.24.88.32.92.4-1.62.6-2.8-0.4-2.9-2.51.8-2.60.71.62.1
Bone: endosteal perimeter3.26.613.13.63.3-2.33.0-3.5-0.7-3.0-2.51.5-2.91.31.72.0
Epididymis fat weight2.04.611.73.43.4-3.22.9-3.0-1.8-1.0-0.5-0.9-1.50.50.9-0.2
Delta time in closed arm before/after self-admin0.90.91.80.20.8-1.20.7-0.3-1.31.21.1-1.30.4-0.5-0.9-1.1
Delta time in open arm before/after self-admin0.50.51.20.20.20.30.1-0.60.8-1.0-1.11.0-0.80.70.50.9
Diff in mean of infusions in LGA sessions0.60.62.8-1.7-1.00.7-0.81.00.40.80.7-0.40.5-0.4-0.5-0.3
Delay discount exponential model param0.20.20.80.90.7-0.50.7-0.7-0.4-0.3-0.50.2-0.1-0.20.10.0
Extinction: sum of active levers before priming0.20.20.5-0.5-0.30.0-0.10.7-0.20.50.6-0.60.4-0.2-0.6-0.5
Active lever presses in extinction session 60.30.30.7-0.40.1-0.30.30.3-0.50.70.6-0.80.5-0.3-0.8-0.5
Bone: final force1.01.64.10.80.5-1.0-0.1-0.4-2.01.21.2-1.61.2-2.0-1.7-1.0
Bone: final moment1.01.74.91.00.6-1.20.1-0.5-2.11.01.1-1.51.1-2.2-1.7-1.0
Food consumed during 24 hour testing period0.81.02.60.90.8-1.30.5-0.5-1.60.71.0-1.40.7-1.0-1.0-0.9
Glucose0.20.41.2-0.5-0.70.9-1.11.00.50.40.3-0.10.60.10.20.4
Heart weight2.02.86.71.81.3-1.90.9-0.5-2.51.01.2-1.41.6-2.0-1.7-2.6
Delay discount hyperbolic model param0.20.20.50.70.5-0.30.6-0.7-0.2-0.4-0.60.4-0.2-0.00.20.2
Intermittent access intake day 1-15 change0.20.20.7-0.4-0.70.6-0.60.80.4-0.00.10.10.30.00.40.0
Intermittent access intake escalation0.20.20.8-0.3-0.80.7-0.60.90.5-0.1-0.00.30.30.10.40.1
Intermittent access intake escalation 20.10.10.30.1-0.20.3-0.10.40.4-0.6-0.30.6-0.10.10.30.3
Intermitt. access day 1 inactive lever presses1.41.54.20.2-0.3-0.2-0.60.6-1.31.01.3-1.21.5-2.1-1.9-1.4
Intermitt. access day 15 inactive lever presses3.03.36.5-0.9-0.7-0.4-1.01.0-1.82.52.3-2.12.1-2.3-2.4-2.1
Intermitt. access escalation Index0.30.30.6-0.5-0.50.3-0.60.5-0.30.80.5-0.20.8-0.7-0.6-0.5
Intermittent access day 1 total infusions0.60.61.60.40.6-0.90.3-0.7-1.20.50.9-1.00.5-1.1-0.9-0.8
Intermittent access day 15 total infusions0.30.30.7-0.3-0.50.2-0.70.4-0.40.40.7-0.50.8-0.9-0.4-0.6
Intermittent access terminal intake (last 3 days)0.00.00.10.20.1-0.20.0-0.2-0.2-0.10.2-0.10.0-0.2-0.0-0.1
Intermittent access total infusions0.20.20.50.20.2-0.4-0.1-0.2-0.70.40.6-0.60.5-0.6-0.6-0.6
Intermittent access day 1 locomotion0.40.41.2-0.10.3-0.5-0.10.1-0.80.70.9-1.00.6-0.6-1.1-0.7
Intermittent access day 15 total locomotion0.10.10.70.10.1-0.2-0.0-0.3-0.40.20.2-0.30.2-0.4-0.8-0.2
Intermittent access total locomotion0.50.51.3-0.00.1-0.4-0.20.1-0.90.90.9-1.10.7-0.9-1.0-0.8
Intermittent access standard deviation0.60.71.40.90.3-0.6-0.30.1-1.20.81.0-1.01.0-1.0-0.7-0.9
Left kidney weight5.415.236.05.95.2-6.04.3-4.4-6.0-0.10.5-2.7-0.4-3.0-2.3-1.8
Right kidney weight6.016.840.06.15.3-6.34.5-4.0-6.30.21.0-3.3-0.0-3.4-2.5-2.8
Cocaine induced anxiety1.31.54.3-0.3-0.0-0.4-0.60.4-1.42.11.6-1.61.6-1.5-0.8-1.2
Post-drug Anxiety0.40.51.6-0.4-0.1-0.1-0.30.0-0.81.30.7-0.60.9-1.1-0.4-0.7
Baseline Anxiety0.90.92.0-0.6-0.40.80.00.01.4-1.3-1.21.4-1.01.10.80.9
Tail length0.20.61.60.3-0.00.40.5-0.00.9-1.2-1.11.2-0.70.80.80.4
Length with tail0.41.33.82.01.2-1.01.2-1.8-0.7-1.5-1.20.8-1.0-0.3-0.00.6
Length without tail0.40.92.41.40.9-1.10.5-1.5-1.6-0.1-0.1-0.5-0.3-1.3-0.90.1
Times rat made contact with spout0.70.83.00.30.3-1.00.50.0-1.10.50.9-1.20.6-0.9-0.9-1.7
Lifetime Intake1.01.12.00.20.1-0.7-0.40.1-1.41.21.4-1.41.2-1.3-1.4-1.2
Liver weight, left1.62.65.92.31.9-1.21.8-2.4-0.3-2.0-1.81.0-1.80.71.00.9
Liver weight, right2.64.410.03.23.1-2.42.6-2.7-0.8-2.0-1.80.5-2.21.31.41.0
Locomotor activity1.11.73.92.02.0-1.81.9-1.9-1.4-0.8-0.7-0.1-0.8-0.20.10.1
Locomotor testing distance0.00.10.2-0.2-0.00.20.0-0.10.2-0.1-0.30.3-0.20.30.20.4
Locomotor testing rearing0.81.33.41.61.9-1.81.7-1.4-1.1-0.5-0.1-0.5-0.60.30.1-0.4
Locomotion in novel chamber2.53.16.00.91.0-0.11.6-1.41.5-2.3-2.22.1-2.22.41.91.8
Locomotion in novel chamber post-restriction0.50.62.0-0.7-0.60.9-0.60.41.3-0.3-0.40.7-0.41.40.80.9
Fecal boli incidents, locomotor time 10.20.20.8-0.9-0.70.7-0.20.80.50.40.10.00.10.10.00.2
Change in fecal boli incidents, locomotor task1.11.03.70.90.9-0.81.2-1.9-0.2-1.2-1.10.8-1.20.40.90.4
Time >=10cm from walls, locomotor time 10.00.00.10.20.10.0-0.1-0.1-0.20.1-0.0-0.1-0.0-0.2-0.20.1
Bouts of movement, locomotor time 10.10.20.8-0.30.1-0.2-0.30.1-0.20.60.6-0.90.10.2-0.0-0.2
Total resting periods, locomotor time 10.50.51.6-0.6-0.30.1-0.90.7-0.21.21.1-1.20.6-0.1-0.5-0.5
Rest time, locomotor task time 11.41.54.5-0.3-0.2-0.2-0.91.2-0.82.01.9-2.11.3-0.7-1.2-1.1
Distance moved, locomotor task time 10.80.92.01.31.2-0.91.3-1.4-0.4-1.3-0.80.5-1.00.2-0.00.5
Vertical activity count, locomotor time 10.20.20.70.30.10.10.2-0.6-0.1-0.8-0.50.8-0.2-0.2-0.10.2
Time >=10cm from walls, locomotor time 20.10.10.30.20.00.30.1-0.10.5-0.4-0.40.5-0.40.40.30.4
Bouts of movement, locomotor time 20.91.02.6-0.4-0.1-0.3-0.70.7-0.81.51.6-1.61.2-1.0-0.9-0.9
Total resting periods, locomotor time 21.11.22.7-0.7-0.3-0.1-0.90.9-0.81.61.7-1.61.3-1.1-1.0-1.0
Rest time, locomotor task time 20.30.31.0-1.0-0.70.4-0.90.70.10.80.6-0.50.5-0.20.0-0.3
Distance moved, locomotor task time 20.80.92.61.61.5-1.31.4-1.2-0.6-0.9-0.3-0.2-0.70.3-0.30.3
Vertical activity count, locomotor time 20.50.51.61.31.0-0.81.1-1.0-0.5-0.7-0.40.2-0.5-0.0-0.20.2
Light reinforcement 10.81.42.91.01.0-0.41.0-1.30.2-1.2-1.71.5-1.50.90.71.7
Light reinforcement 20.40.51.61.01.3-0.90.7-0.8-0.60.1-0.3-0.1-0.70.40.10.9
Bone: marrow area2.35.08.83.02.5-1.62.6-2.8-0.5-2.9-2.51.8-2.60.61.52.1
Bone: maximum diameter2.34.312.93.63.0-2.92.6-2.9-2.5-1.4-0.8-0.2-1.0-0.9-0.20.1
Bone: maximum force1.32.26.51.61.3-1.90.7-1.0-2.50.91.1-1.80.9-1.9-1.6-1.1
Bone: maximum moment1.42.57.31.81.4-2.00.9-1.1-2.70.81.0-1.80.8-2.1-1.6-1.2
Mean time between licks in bursts0.20.41.1-1.1-0.60.7-0.50.60.80.3-0.20.50.30.70.2-0.4
Mean num. licks in bursts0.91.12.41.51.3-1.51.2-1.1-1.40.10.4-1.00.2-0.4-0.7-1.2
Cd content in liver1.11.23.51.51.5-1.81.9-0.8-0.7-0.7-0.5-0.1-0.40.60.5-1.2
Co content in liver0.60.72.9-0.10.4-0.90.8-0.0-0.91.10.4-0.50.7-0.8-1.1-1.7
Cu content in liver1.92.36.7-1.9-2.12.6-1.91.42.0-0.1-0.31.30.20.50.51.6
Fe content in liver0.50.61.81.20.6-0.00.7-0.9-0.0-1.3-1.01.0-0.70.00.21.0
K content in liver0.70.71.9-1.0-1.41.3-1.11.00.20.60.9-0.20.7-0.7-0.60.2
Mg content in liver1.61.64.4-1.2-1.91.8-2.11.50.20.91.1-0.31.3-0.8-0.80.8
Mn content in liver0.40.41.10.60.7-0.60.9-0.50.0-0.5-0.50.2-1.01.00.70.5
Na content in liver1.31.33.8-1.9-1.71.9-1.41.21.50.40.10.70.40.50.10.3
Rb content in liver0.10.10.3-0.1-0.50.3-0.50.1-0.30.20.30.00.4-0.3-0.40.3
Se content in liver0.50.61.3-0.6-0.50.9-0.10.11.1-0.7-0.50.9-0.80.70.91.0
Sr content in liver0.50.51.5-1.2-0.70.4-0.20.91.00.40.4-0.20.20.70.3-1.0
Zn content in liver0.80.92.4-0.7-0.81.1-0.50.21.2-0.6-1.01.5-0.51.00.71.4
Bone: minimum diameter0.91.83.51.91.7-1.21.3-1.9-0.6-1.5-1.10.7-1.40.51.01.6
Time in familiar zone, hab. session 10.20.20.60.20.3-0.40.4-0.50.1-0.5-0.2-0.0-0.70.30.60.3
Time in novel zone, hab. session 10.60.61.71.21.2-1.11.3-0.7-0.7-0.3-0.70.4-0.00.1-0.1-0.7
Total zone transitions, hab. session 11.72.45.6-2.3-1.72.0-0.90.52.4-0.8-1.02.0-1.11.11.51.5
Total locomotion distance, hab. session 12.33.36.4-0.7-0.41.00.3-0.52.1-2.2-2.12.4-2.31.92.42.5
Locomotion velocity, hab. session 11.82.66.2-1.1-0.81.4-0.30.12.1-1.8-1.52.1-1.81.52.02.5
Time in familiar zone, hab. session 21.41.43.11.11.1-0.61.2-0.70.8-1.8-1.20.9-1.51.41.60.8
Time in novel zone, hab. session 20.80.81.8-0.6-0.70.1-0.40.3-0.91.20.7-0.41.2-1.3-1.3-1.3
Total zone transitions, hab. session 20.40.52.1-1.4-1.31.1-0.80.40.60.20.10.7-0.0-0.6-0.20.4
Total locomotion distance, hab. session 20.30.41.5-1.2-0.91.0-0.70.60.70.20.20.3-0.00.10.20.4
Locomotion velocity, hab. session 20.60.82.4-1.5-1.31.4-0.90.91.10.10.20.5-0.10.20.50.7
Novel to familiar place preference ratio2.32.45.72.31.9-1.92.4-2.3-1.3-1.3-1.60.8-0.8-0.3-0.1-0.8
Novelty place preference3.13.27.72.62.3-2.32.8-2.5-1.4-1.5-1.70.8-1.0-0.20.1-1.0
Time in novel zone, NPP test3.63.79.02.92.5-2.63.0-2.7-1.6-1.5-1.70.7-1.0-0.3-0.0-1.1
Total zone transitions, NPP test1.31.84.4-2.1-1.71.7-0.80.41.9-0.8-0.81.8-0.91.01.11.1
Total locomotion distance, NPP test0.60.82.5-1.6-1.31.3-0.70.61.2-0.2-0.10.8-0.40.50.70.7
Locomotion velocity, NPP test1.01.43.5-1.9-1.51.7-1.00.81.8-0.4-0.21.0-0.61.11.11.2
Intraocular pressure0.20.31.60.50.7-0.80.6-1.3-0.3-0.2-0.1-0.3-0.50.2-0.10.3
Delta distance traveled before/after self-admin1.31.44.31.31.0-0.81.7-2.1-0.4-1.6-1.51.1-1.2-0.20.40.3
Delta ambulatory time before/after self-admin1.41.54.51.10.9-0.91.8-2.1-0.6-1.6-1.51.3-1.2-0.50.20.2
Parametrial fat weight0.30.51.4-0.10.1-0.40.00.4-0.61.10.9-1.00.7-0.6-0.9-1.2
Pavlov. Cond. lever latency1.01.23.11.31.4-1.51.8-1.7-0.8-0.5-1.10.6-0.50.5-0.1-1.0
Pavlov. Cond. magazine entry latency1.51.94.6-1.8-1.61.2-1.62.20.51.51.7-1.21.3-0.6-0.4-0.9
Pavlov. Cond. change in total contacts2.32.55.3-2.0-1.91.4-2.02.30.41.62.1-1.51.5-1.3-0.8-0.6
Pavlov. Cond. index score1.62.14.6-1.5-1.41.0-1.72.10.11.62.1-1.71.4-1.1-0.8-0.7
Pavlov. Cond. latency score1.41.73.9-1.3-1.30.9-1.62.00.11.51.9-1.51.3-1.1-0.7-0.6
Pavlov. Cond. lever contacts1.51.84.8-1.7-1.61.5-1.92.20.81.21.6-1.00.9-0.6-0.20.2
Pavlov. Cond. magazine entry number1.31.63.91.51.4-0.91.4-2.0-0.4-1.3-1.81.4-1.20.50.40.9
Pavlov. Cond. intertrial magazine entries0.60.72.1-1.3-1.51.4-1.10.70.60.50.10.60.7-0.5-0.2-0.0
Pavlov. Cond. lever-magazine prob. diff.1.62.04.3-1.7-1.51.1-1.82.10.31.62.0-1.51.3-0.8-0.6-0.5
Pavlov. Cond. response bias1.82.25.1-1.8-1.61.3-1.92.30.51.62.0-1.51.3-0.7-0.6-0.4
Pavlov. Cond. lever latency0.81.02.80.81.5-1.71.5-1.1-0.4-0.1-0.2-0.6-0.71.10.6-1.1
Pavlov. Cond. magazine entry latency4.14.711.2-2.9-3.33.1-3.22.40.92.01.30.12.1-1.7-1.3-0.2
Pavlov. Cond. change in total contacts2.43.49.2-1.4-2.21.9-2.41.7-0.61.81.4-0.42.1-3.0-2.3-0.1
Pavlov. Cond. index score2.63.47.9-2.3-2.82.6-2.82.00.61.51.00.21.7-1.8-1.30.3
Pavlov. Cond. latency score3.34.19.5-2.6-3.12.8-3.02.40.71.71.30.12.0-1.9-1.40.1
Pavlov. Cond. lever contacts1.01.43.6-1.0-1.71.8-1.91.30.30.50.40.40.9-1.4-0.91.2
Pavlov. Cond. magazine entry number2.93.57.72.42.8-2.62.8-1.9-0.4-1.8-1.30.1-1.81.91.50.1
Pavlov. Cond. intertrial magazine entries1.82.45.51.11.5-2.31.2-0.3-2.01.21.5-2.30.8-0.5-1.4-2.1
Pavlov. Cond. lever-magazine prob. diff.2.53.27.7-2.2-2.72.7-2.81.90.71.30.80.41.6-1.7-1.10.6
Pavlov. Cond. response bias1.52.15.2-1.4-2.02.0-2.31.40.21.00.80.21.4-1.8-1.30.8
Time in closed arm before self-admin2.63.07.3-2.1-2.22.7-2.32.62.1-0.1-0.31.50.80.51.31.0
Time in closed arm after self-admin0.20.20.70.40.8-0.80.60.3-0.50.40.5-0.60.1-0.10.4-0.1
Time in open arm before self-admin0.50.61.20.70.6-0.40.9-1.10.4-0.8-0.70.3-1.11.00.60.6
Time in open arm after self-admin1.01.12.30.60.30.40.4-1.11.1-1.5-1.41.1-1.21.50.91.2
Bone: periosteal estimation1.83.68.93.02.5-2.02.3-2.8-1.2-2.1-1.60.9-1.80.00.91.4
Bone: periosteal perimeter3.15.213.53.73.4-2.82.8-3.3-1.6-2.1-1.60.4-2.00.50.91.2
Bone: post-yield work0.40.61.10.1-0.0-0.5-0.20.2-1.00.81.0-1.00.8-0.9-1.1-0.7
Progressive ratio test 1 active lever presses0.91.02.3-0.1-0.2-0.4-0.60.2-1.01.11.5-1.51.1-1.1-1.4-1.1
Progressive ratio test 1 breakpoint0.50.61.6-0.1-0.1-0.3-0.40.1-0.70.81.2-1.20.7-0.7-1.1-0.8
Progressive ratio test 1 inactive lever presses2.62.85.8-0.1-0.5-0.1-1.41.4-1.51.82.4-2.22.2-1.9-2.2-1.8
Progressive ratio test 2 active lever presses1.01.01.9-1.1-1.10.4-1.30.9-0.51.21.4-1.01.2-0.9-0.9-0.9
Progressive ratio test 2 breakpoint1.31.42.9-1.0-1.00.2-1.31.1-0.81.41.7-1.41.4-1.2-1.1-1.2
Progressive ratio test 2 inactive lever presses2.22.64.3-1.8-1.70.9-2.11.7-0.51.91.9-1.32.1-1.4-1.3-1.3
Incentive Sensitization - Responses0.90.91.8-0.9-1.20.7-1.31.3-0.20.71.1-0.61.2-0.8-0.8-0.7
Incentive Sensitization - Breakpoint1.01.01.7-0.8-1.10.5-1.31.3-0.50.91.3-0.91.3-1.0-0.9-0.9
Sum of active levers in priming session hrs 5-60.10.10.5-0.1-0.20.2-0.20.70.10.10.2-0.30.3-0.1-0.3-0.2
Progressive ratio0.20.30.7-0.7-0.60.5-0.70.8-0.10.40.5-0.20.7-0.5-0.2-0.1
Food seeking constrained by brief footshock0.70.92.00.91.3-1.40.9-1.3-1.40.30.5-1.1-0.1-0.4-0.8-0.3
Seeking ratio, punishment vs. effort0.40.51.00.80.9-1.00.7-0.9-0.80.20.3-0.8-0.2-0.1-0.7-0.4
Retroperitoneal fat weight1.65.213.83.73.5-3.62.7-2.4-2.9-0.10.5-2.1-0.7-0.6-0.5-1.1
Reaction time number correct1.31.83.4-0.9-0.41.10.2-0.51.8-1.6-1.51.7-1.51.81.81.3
Reaction time mean minus median0.40.61.80.61.0-1.01.3-0.4-0.1-0.5-0.90.6-0.40.60.6-0.8
Reaction time mean minus median AUC0.60.82.11.01.4-1.41.5-0.6-0.6-0.2-0.4-0.1-0.10.50.5-1.2
Reaction time num false alarms1.01.42.30.61.0-0.41.4-0.80.6-1.3-1.51.5-1.51.31.51.1
Reaction time num false alarms AUC1.11.52.90.30.8-0.31.3-0.80.7-1.3-1.61.7-1.61.21.61.2
Reaction time trials correct on left1.31.83.4-0.9-0.41.10.2-0.51.8-1.6-1.51.7-1.51.81.81.3
Reaction time trials on left1.42.03.6-0.9-0.41.10.2-0.51.9-1.6-1.51.8-1.61.91.91.3
Reaction time mean0.10.10.3-0.6-0.20.3-0.10.30.20.2-0.10.50.30.20.3-0.4
Reaction time mean AUC0.10.10.3-0.5-0.20.3-0.10.30.30.20.00.30.30.20.3-0.4
Median of all reaction times0.20.31.0-1.0-0.70.7-0.70.50.40.50.20.40.50.00.1-0.2
Reaction time omissions0.30.41.6-0.7-0.10.10.4-0.20.8-0.4-0.60.9-0.50.81.2-0.4
Reaction time false alarm rate0.20.30.90.50.9-0.80.9-0.3-0.3-0.1-0.40.4-0.40.30.50.2
Reaction time premature initiation rate0.60.81.7-0.6-1.21.1-1.31.3-0.30.50.5-0.10.9-1.2-0.81.0
Reaction time premature initiations0.40.61.8-0.9-1.21.4-1.00.90.4-0.0-0.10.50.2-0.40.01.1
Std. dev. reaction times0.40.51.60.71.1-1.11.3-0.8-0.5-0.3-0.70.4-0.30.40.3-0.6
Reaction time trials completed1.42.03.6-0.9-0.41.10.2-0.51.9-1.6-1.51.8-1.61.91.91.3
Reaction time trials AUC1.21.72.9-0.8-0.41.00.2-0.51.7-1.6-1.51.7-1.51.71.71.4
Run reversals in cocaine runway, females1.61.53.0-0.10.20.50.6-0.71.5-1.5-1.61.6-1.71.51.51.5
Run reversals in cocaine runway, males1.01.04.00.90.9-0.91.4-2.0-0.3-1.1-0.90.5-1.20.41.00.1
Latency to leave start box in cocaine runway0.10.10.40.60.4-0.50.4-0.0-0.30.30.2-0.50.1-0.3-0.0-0.3
Latency to leave start box in cocaine runway, F0.10.10.5-0.2-0.30.5-0.20.40.6-0.1-0.30.5-0.20.20.70.3
Latency to leave start box in cocaine runway, M1.41.33.21.10.9-1.30.5-0.2-1.61.01.2-1.80.8-1.1-1.3-1.2
Std. dev. time between licks in bursts0.91.12.8-1.5-1.71.6-1.71.20.60.30.30.40.8-0.5-0.30.6
Total sessions with >9 infusions1.11.23.00.80.7-1.20.3-0.2-1.71.01.2-1.40.8-1.1-1.4-1.2
Short access day 1 total inactive lever presses1.01.13.10.50.5-1.00.4-0.5-1.70.90.8-1.00.8-1.8-1.3-1.2
Short access day 10 total inactive lever presses0.40.40.90.80.8-0.80.8-0.9-0.80.1-0.2-0.2-0.1-0.8-0.7-0.3
Short access day 1 total infusions1.51.63.70.90.7-1.30.3-0.2-1.91.21.4-1.51.1-1.6-1.8-1.4
Short access day 10 total infusions0.70.82.40.10.3-0.6-0.30.3-1.01.31.4-1.50.9-0.7-1.0-1.0
Short access total infusions2.52.85.60.60.6-1.3-0.30.2-2.22.12.2-2.41.6-1.7-2.3-1.8
Short access day 1 locomotion0.70.72.2-0.40.0-0.2-0.50.7-0.71.51.3-1.11.0-0.7-0.8-0.8
Short access day 10 total locomotion0.40.51.3-0.40.1-0.0-0.51.0-0.21.11.0-1.10.70.2-0.4-0.2
Short access total locomotion1.61.74.80.10.7-1.0-0.20.7-1.41.91.9-2.21.2-0.8-1.5-1.1
One hour access (0.3 mA shock)0.20.31.0-1.0-0.60.5-0.80.40.50.40.4-0.00.30.40.40.1
Compulsive drug intake1.01.02.7-1.6-1.61.4-1.00.61.3-0.2-0.51.2-0.10.51.10.5
One hour access (shock baseline)0.10.10.40.30.4-0.2-0.20.0-0.10.10.5-0.60.20.30.0-0.0
Social response proportion0.60.71.80.3-0.0-0.1-0.40.6-0.81.00.8-0.61.3-1.0-1.0-1.3
Social responses0.30.41.60.50.10.00.4-0.10.3-0.6-0.80.7-0.70.71.30.5
Social time1.11.54.3-1.8-1.61.6-1.62.11.30.80.7-0.00.60.60.5-0.0
Soleus weight0.20.61.6-1.3-1.00.6-0.60.60.00.80.7-0.00.6-0.8-0.9-0.7
Bone: stiffness0.81.23.51.21.0-1.30.2-0.5-1.90.91.0-1.50.8-1.1-1.2-0.6
Tibialis anterior weight0.62.05.7-2.4-1.81.4-1.42.00.81.60.9-0.11.50.0-0.4-1.5
Time to tail flick, vehicle, before self-admin0.40.41.00.40.3-0.21.0-0.50.1-0.9-0.80.7-0.80.30.60.5
Time to tail flick, vehicle, after self-admin2.52.75.50.10.30.51.1-0.81.7-2.2-2.22.0-2.01.92.31.7
Time to tail flick, test, before self-admin1.21.23.40.50.8-0.61.3-1.10.5-1.0-1.00.5-1.41.41.80.9
Time to tail flick, test, after self-admin0.60.71.7-0.7-0.71.0-0.60.51.3-0.6-0.61.0-0.40.90.91.0
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.4-0.30.4-0.40.40.20.20.0-0.20.40.30.4-0.1
Delta time to tail flick, test, before/after SA1.21.12.9-1.1-1.51.7-1.51.21.3-0.3-0.41.30.3-0.00.00.5
Tibia length0.41.02.81.71.0-1.30.7-1.6-1.5-0.7-0.60.1-0.2-1.1-0.80.1
Ambulatory time before self-admin1.11.12.2-0.7-0.70.3-1.21.4-0.41.51.5-1.21.4-0.7-0.9-1.0
Ambulatory time after self-admin0.30.31.5-1.2-0.90.7-0.50.10.10.1-0.20.60.4-0.70.2-0.3
Bone: tissue strength0.10.10.40.50.1-0.10.1-0.7-0.5-0.4-0.10.1-0.0-0.40.00.2
Total heroin consumption0.40.51.4-0.9-0.4-0.00.00.7-0.50.80.7-0.70.6-0.7-1.2-0.6
Bone: trabecular number0.20.40.80.30.4-0.00.4-0.80.4-0.6-0.90.6-0.80.70.60.7
Bone: trabecular spacing0.60.82.40.90.6-1.10.1-0.1-1.40.41.2-1.50.6-0.8-0.9-0.6
Bone: trabecular thickness0.10.10.3-0.5-0.20.6-0.30.10.40.3-0.30.40.00.20.10.5
Bone: trabecular tissue density1.01.43.3-1.8-1.71.6-1.21.70.71.10.40.41.3-1.0-0.5-0.5
Water consumed over 24 hours0.40.51.20.80.6-1.10.9-0.8-1.1-0.1-0.1-0.30.1-0.9-0.4-0.9
Number of responses in last shaping day2.12.26.2-1.6-1.51.1-2.02.50.01.71.7-1.01.8-0.8-0.8-0.9