Hub : Genes

Spryd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL mRNA stability Spryd3 0.34 0.16 6.4e-04 0.13 0.08 0.05 0.1 6.2e-04 4.7e-03 2.4e-02 2.7e-03
2 BLA gene expression Spryd3 0.1 0.03 9.4e-07 0.09 0.1 0.05 0.09 2.1e-05 4.6e-06 1.3e-03 1.9e-05
3 NAcc gene expression Spryd3 0.08 0.01 0.0e+00 0.36 0.38 0.37 0.38 7.5e-44 6.8e-46 1.7e-45 1.3e-46
4 PL mRNA stability Spryd3 0.09 0.04 1.6e-04 0.04 0.04 0.03 0.04 4.3e-05 7.7e-05 3.2e-04 6.6e-05
5 Brain gene expression Spryd3 0.29 0.12 2.1e-12 0.14 0.14 0.15 0.15 4.7e-13 3.8e-13 6.9e-14 5.4e-14
6 Brain mRNA stability Spryd3 0.25 0.1 4.4e-15 0.17 0.17 0.18 0.19 4.3e-16 6.3e-16 1.1e-16 2.2e-17
7 Adipose gene expression Spryd3 0.26 0.09 0.0e+00 0.18 0.16 0.17 0.17 1.9e-19 6.1e-18 5.3e-19 4.7e-19
8 IL gene expression Spryd3 0.43 0.16 3.5e-06 0.17 0.2 0.23 0.24 8.0e-05 1.2e-05 3.6e-06 1.9e-06
9 PL gene expression Spryd3 0.08 0.01 5.7e-15 0.15 0.15 0.15 0.15 4.2e-16 4.8e-16 5.3e-16 2.0e-16
10 NAcc mRNA stability Spryd3 0.04 0.02 2.7e-04 0.05 0.03 0.04 0.04 1.5e-06 9.0e-05 3.5e-05 5.3e-06
11 Liver gene expression Spryd3 0.11 0.05 8.5e-09 0.06 0.08 0.07 0.07 1.6e-07 3.0e-09 1.0e-08 1.8e-08
12 Eye gene expression Spryd3 0.39 0.2 2.2e-03 0.34 0.11 0.34 0.36 4.0e-06 1.0e-02 2.9e-06 1.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.62.85.22.3-1.7-1.81.6-1.8-1.61.6-1.6-1.71.61.3-1.1
Area under the delay curve0.40.41.20.7-0.5-0.70.7-0.5-0.60.8-0.6-0.50.60.4-1.1
BMI with tail1.24.06.72.6-1.8-2.22.1-2.0-2.02.1-2.0-2.02.01.5-1.6
BMI without tail0.20.51.00.7-0.0-0.71.0-0.7-0.80.8-0.7-0.70.80.40.4
Body weight0.41.53.41.8-0.8-1.41.3-1.3-1.21.4-1.2-1.31.30.5-0.8
Weight adjusted by age0.70.82.0-0.71.40.8-0.90.70.8-0.90.60.7-1.0-1.40.6
Bone surface3.56.18.62.9-2.6-2.62.5-2.5-2.42.5-2.3-2.42.52.3-2.0
Bone volume3.05.27.32.7-2.2-2.42.3-2.3-2.22.3-2.2-2.22.32.1-1.7
Breakpoint value in progressive ratio session3.53.86.62.1-2.3-1.82.6-1.8-1.91.7-1.4-1.71.82.3-1.6
Number of licking bursts0.20.21.6-1.30.30.30.10.20.00.00.10.1-0.10.10.9
Context. condit. distance diff. score0.70.82.11.4-0.8-0.90.9-0.9-0.70.9-0.6-0.80.81.4-0.3
Locomotion velocity, session 15.05.49.9-3.12.72.3-2.02.12.0-2.02.12.0-1.9-2.22.9
Locomotion distance, session 13.54.57.4-2.72.52.1-1.82.01.9-1.91.91.9-1.8-2.02.4
Locomotion velocity, session 22.12.45.8-2.21.91.4-1.01.31.0-1.11.21.2-1.0-2.12.4
Locomotion distance, session 24.25.97.3-2.52.72.5-2.42.52.4-2.42.32.4-2.3-2.32.4
Locomotion velocity, session 32.42.85.5-2.31.71.6-1.41.61.4-1.41.61.4-1.5-1.72.1
Locomotion distance, session 31.31.44.3-1.01.01.1-1.01.11.1-1.01.21.0-1.0-1.12.1
Stereotopy head waving bouts, day 30.91.01.50.1-0.8-1.01.0-1.1-1.11.1-1.2-1.21.01.1-1.0
Stereotopy head waving duration, day 30.30.40.5-0.5-0.2-0.50.6-0.6-0.70.7-0.7-0.70.70.5-0.7
Locomotion velocity, session 71.01.12.2-1.51.01.2-1.11.11.1-1.01.11.1-1.0-0.30.5
Locomotion distance, session 72.12.73.9-2.01.71.7-1.61.71.6-1.61.71.6-1.6-1.51.2
Stereotopy head waving bouts, day 70.60.60.90.8-0.8-0.80.6-0.8-0.70.7-0.9-0.80.71.0-0.9
Stereotopy head waving duration, day 71.61.92.61.3-1.4-1.31.2-1.3-1.31.3-1.4-1.31.31.5-1.6
Locomotion velocity, session 80.00.00.1-0.30.30.10.1-0.0-0.00.10.0-0.00.00.30.2
Locomotion distance, session 81.42.13.9-1.31.61.4-1.41.41.4-1.31.51.4-1.3-1.12.0
Degree of sensitization distance0.10.10.8-0.50.40.2-0.20.20.2-0.30.10.2-0.2-0.0-0.9
Degree of sensitization stereotypy1.11.21.71.2-1.3-1.00.9-1.0-1.00.9-1.1-1.00.91.3-1.2
Conditioned locomotion0.81.02.6-1.01.60.8-0.80.80.9-0.90.90.9-0.8-0.61.3
Cocaine response after cond. corrected1.71.93.2-1.61.81.5-1.31.51.4-1.41.31.4-1.3-1.40.6
Cocaine response after cond. not corrected1.71.92.6-1.41.61.4-1.31.41.4-1.41.41.4-1.4-1.40.7
Cocaine response before conditioning0.00.00.20.1-0.4-0.0-0.20.00.1-0.20.1-0.0-0.30.30.0
Saline control response0.30.41.50.10.50.5-0.60.60.6-0.60.70.7-0.80.01.2
Bone: connectivity density0.20.31.51.2-0.7-0.50.2-0.4-0.20.2-0.2-0.30.30.3-0.5
Bone: cortical apparent density1.01.33.2-1.01.81.3-1.01.21.2-1.01.11.2-1.0-1.10.4
Bone: cortical area1.01.54.42.1-1.6-1.31.0-1.1-1.01.0-1.0-1.01.11.1-0.9
Bone: cortical porosity0.10.10.70.10.20.1-0.20.20.2-0.50.40.2-0.4-0.20.9
Bone: cortical porosity0.40.41.5-0.20.50.4-0.60.50.6-0.80.70.5-0.7-0.51.2
Bone: cortical thickness0.00.10.50.7-0.3-0.1-0.20.00.2-0.00.10.10.0-0.1-0.5
Bone: cortical thickness3.64.26.0-1.31.92.0-2.22.12.2-2.22.22.2-2.1-2.41.4
Bone: cortical tissue density1.21.63.8-1.11.91.4-1.11.31.3-1.11.21.3-1.1-1.20.6
Condit. Reinf. active minus inactive responses0.80.91.5-0.20.70.8-1.11.01.0-1.10.91.0-1.1-0.71.2
Condit. Reinf. active-inactive response ratio0.40.50.70.10.30.6-0.80.70.7-0.80.70.7-0.8-0.60.7
Condit. Reinf. active responses2.02.44.2-1.01.61.4-1.61.61.5-1.71.51.6-1.6-1.32.0
Condit. Reinf. inactive responses2.83.45.5-2.12.31.8-1.61.81.7-1.71.71.8-1.6-1.62.0
Incentive salience index mean0.40.51.4-0.00.40.6-0.80.80.7-0.80.70.8-0.8-0.51.2
Condit. Reinf. lever presses0.00.00.2-0.0-0.1-0.00.00.1-0.0-0.0-0.10.00.10.00.5
Condit. Reinf. active minus inactive responses0.60.82.70.9-1.0-0.70.9-0.8-0.80.7-0.8-0.70.60.8-1.6
Condit. Reinf. active-inactive response ratio0.60.72.00.9-0.9-0.70.8-0.7-0.70.7-0.7-0.70.60.7-1.4
Condit. Reinf. active responses0.60.82.00.5-1.0-0.70.9-0.8-0.90.7-0.9-0.70.71.1-1.4
Condit. Reinf. inactive responses0.10.10.4-0.60.20.3-0.10.20.1-0.20.10.1-0.10.10.4
Condit. Reinf. lever presses0.30.40.8-0.40.40.7-0.70.80.8-0.70.90.8-0.8-0.30.2
Condit. Reinf. lever reinforcers received0.20.21.10.1-0.5-0.20.5-0.3-0.40.3-0.3-0.20.20.7-1.1
Conditioned reinforcement - actives0.40.42.7-1.10.40.50.00.50.20.10.30.3-0.10.1-1.6
Conditioned reinforcement - inactives1.71.92.8-0.41.01.4-1.61.61.6-1.61.61.7-1.7-1.00.3
Conditioned locomotion0.20.32.1-0.2-0.30.10.5-0.1-0.10.30.2-0.00.30.5-1.4
Patch foraging indifference point 0 sec1.01.73.4-1.41.21.3-1.31.21.2-1.41.11.2-1.3-0.71.8
Patch foraging indifference point AUC1.51.72.6-1.61.31.3-1.51.31.4-1.41.21.2-1.3-0.81.2
Delay disc. indifference point, 0s delay0.10.10.4-0.20.60.10.00.10.10.00.20.0-0.1-0.5-0.4
Delay disc. indifference point, 16s delay0.20.20.80.9-0.3-0.40.2-0.3-0.20.3-0.2-0.30.40.4-0.7
Delay disc. indifference point, 2s delay2.62.85.21.1-1.6-1.51.9-1.5-1.71.9-1.8-1.51.61.6-2.3
Delay disc. indifference point, 24s delay0.30.30.80.7-0.2-0.50.5-0.4-0.50.5-0.5-0.40.50.4-0.9
Delay disc. indifference point, 4s delay0.80.81.40.9-1.0-0.90.9-0.8-0.81.1-0.7-0.70.90.8-1.2
Delay disc. indifference point, 8s delay0.20.20.40.5-0.4-0.50.6-0.4-0.50.6-0.4-0.40.40.3-0.5
Indifference point function ln k3.44.87.22.5-2.0-2.22.7-2.3-2.42.3-2.0-2.22.31.6-1.3
Indifference point function log k3.44.87.22.5-2.0-2.22.7-2.3-2.42.3-2.0-2.22.31.6-1.3
Patch foraging total patch changes 0 sec1.32.14.7-1.51.41.4-1.41.31.3-1.51.31.3-1.5-0.92.2
Patch foraging total patch changes 12 sec3.44.46.4-2.02.12.1-2.52.22.3-2.42.02.1-2.1-1.11.7
Patch foraging total patch changes 18 sec3.44.46.5-2.62.02.1-2.42.12.1-2.11.91.9-2.1-1.22.3
Patch foraging total patch changes 24 sec0.70.82.0-1.20.50.8-1.20.80.9-1.10.70.7-0.90.11.4
Patch foraging total patch changes 6 sec1.32.04.9-2.21.41.4-1.61.31.3-1.71.01.2-1.4-0.81.1
Patch foraging time to switch 0 sec0.20.31.0-0.80.50.5-0.40.50.3-0.30.30.5-0.6-0.5-1.0
Patch foraging water rate 0 sec0.20.41.11.0-0.8-0.60.4-0.6-0.50.2-0.5-0.60.50.60.6
Patch foraging water rate 12 sec0.20.41.91.4-0.8-0.60.5-0.4-0.4-0.0-0.2-0.40.10.40.7
Patch foraging water rate 18 sec0.10.10.70.8-0.3-0.2-0.0-0.2-0.00.0-0.1-0.20.20.5-0.1
Patch foraging water rate 24 sec0.60.81.41.2-0.8-0.91.0-0.9-0.90.7-0.8-0.91.01.2-0.7
Patch foraging water rate 6 sec1.52.16.72.6-1.8-1.61.1-1.4-1.31.1-1.2-1.31.31.40.2
Seeking ratio, delayed vs. immediate footshock0.20.20.40.10.60.4-0.10.60.40.50.60.6-0.0-0.40.1
Distance traveled before self-admin0.10.10.7-0.2-0.1-0.0-0.2-0.00.1-0.30.0-0.0-0.10.3-0.8
Distance traveled after self-admin0.20.31.01.0-0.80.0-0.40.20.3-0.40.30.2-0.20.6-0.8
Extensor digitorum longus weight6.324.829.14.3-4.3-5.15.4-5.1-5.35.1-5.4-5.15.14.2-5.3
Bone: elastic displacement1.71.94.7-2.21.91.4-1.11.41.2-1.11.51.3-1.2-1.11.0
Bone: elastic work0.60.81.8-1.11.10.9-0.50.90.8-0.61.00.9-0.8-1.30.6
Bone: endosteal estimation3.37.19.03.0-2.9-2.92.6-2.8-2.82.6-2.7-2.72.62.6-1.3
Bone: endosteal perimeter2.96.19.23.0-2.7-2.62.5-2.5-2.52.4-2.4-2.42.42.1-1.5
Epididymis fat weight0.92.03.5-0.11.31.2-1.61.31.5-1.51.61.4-1.4-1.91.6
Delta time in closed arm before/after self-admin0.30.31.31.2-0.7-0.60.0-0.4-0.3-0.0-0.4-0.40.10.90.1
Delta time in open arm before/after self-admin3.83.75.5-1.92.22.0-1.32.11.6-1.91.92.0-2.2-2.31.4
Diff in mean of infusions in LGA sessions0.10.10.50.70.0-0.30.5-0.3-0.20.3-0.1-0.20.3-0.2-0.4
Delay discount exponential model param0.80.92.0-0.90.80.9-1.00.80.9-1.10.80.8-0.9-0.61.4
Extinction: sum of active levers before priming4.04.05.01.8-2.0-2.12.2-2.2-2.12.2-2.0-2.12.11.7-0.7
Active lever presses in extinction session 61.21.23.10.7-0.9-1.01.8-1.1-1.21.6-0.8-1.11.10.8-0.6
Bone: final force2.94.66.72.6-2.6-2.32.1-2.2-2.12.1-2.1-2.12.21.6-1.6
Bone: final moment4.06.58.62.9-2.9-2.82.5-2.6-2.52.5-2.5-2.62.62.0-1.7
Food consumed during 24 hour testing period0.20.32.11.4-0.6-0.50.2-0.3-0.30.2-0.2-0.20.20.50.5
Glucose0.20.30.6-0.10.70.5-0.50.50.5-0.70.50.5-0.8-0.80.3
Heart weight0.30.40.60.50.40.5-0.70.70.7-0.60.70.8-0.7-0.5-0.3
Delay discount hyperbolic model param1.11.12.6-1.01.01.0-1.20.91.0-1.21.00.9-1.0-0.81.6
Intermittent access intake day 1-15 change0.30.30.50.4-0.7-0.40.6-0.4-0.50.7-0.3-0.50.50.7-0.7
Intermittent access intake escalation0.60.61.00.5-0.9-0.70.8-0.6-0.70.9-0.5-0.70.71.0-0.7
Intermittent access intake escalation 20.50.50.90.5-0.8-0.70.9-0.7-0.80.8-0.6-0.70.50.9-0.7
Intermitt. access day 1 inactive lever presses0.20.21.21.1-0.6-0.2-0.6-0.10.2-0.4-0.00.1-0.10.4-0.6
Intermitt. access day 15 inactive lever presses0.40.50.90.40.50.6-1.00.60.8-0.90.70.9-0.8-0.50.1
Intermitt. access escalation Index0.90.81.6-0.5-1.0-0.61.0-0.7-0.90.8-0.9-0.80.81.1-1.3
Intermittent access day 1 total infusions0.60.71.3-0.70.61.0-0.91.11.0-0.91.01.1-0.7-0.3-0.1
Intermittent access day 15 total infusions0.30.31.0-1.00.40.7-0.20.80.5-0.20.70.7-0.3-0.0-0.7
Intermittent access terminal intake (last 3 days)0.30.31.6-0.6-0.10.50.20.60.2-0.10.50.4-0.20.6-1.3
Intermittent access total infusions0.20.21.6-0.5-0.30.30.10.40.2-0.00.30.30.00.7-1.3
Intermittent access day 1 locomotion0.30.30.6-0.70.10.7-0.70.70.7-0.70.70.6-0.20.10.1
Intermittent access day 15 total locomotion0.20.20.60.6-0.8-0.30.4-0.3-0.20.5-0.0-0.30.60.6-0.5
Intermittent access total locomotion0.10.20.9-0.1-0.60.0-0.00.00.1-0.10.1-0.10.30.7-0.9
Intermittent access standard deviation0.30.30.6-0.60.70.6-0.20.50.5-0.20.70.5-0.3-0.70.1
Left kidney weight0.30.72.61.6-0.9-0.91.0-0.7-0.90.6-0.8-0.70.70.5-0.5
Right kidney weight1.02.83.41.9-1.8-1.81.7-1.7-1.81.5-1.8-1.71.51.1-1.4
Cocaine induced anxiety2.42.84.31.0-1.8-1.51.8-1.7-1.61.8-1.4-1.61.71.7-2.1
Post-drug Anxiety5.66.27.92.3-2.8-2.52.3-2.6-2.42.5-2.4-2.62.52.6-2.4
Baseline Anxiety0.20.21.11.0-0.0-0.1-0.60.20.3-0.50.10.2-0.4-0.10.8
Tail length0.20.51.3-0.91.10.7-0.50.60.6-0.50.70.6-0.5-0.71.0
Length with tail0.00.10.50.10.60.2-0.20.20.2-0.20.30.3-0.3-0.70.0
Length without tail0.10.21.50.9-0.6-0.40.1-0.3-0.10.2-0.2-0.20.1-0.1-1.2
Times rat made contact with spout0.40.40.60.5-0.8-0.70.7-0.7-0.70.7-0.6-0.70.70.60.3
Lifetime Intake0.20.20.8-0.4-0.30.4-0.20.40.3-0.30.40.4-0.10.7-0.9
Liver weight, left1.11.72.11.3-1.3-1.31.4-1.4-1.41.4-1.2-1.41.31.3-1.1
Liver weight, right0.30.51.41.2-1.0-0.80.6-0.7-0.60.5-0.5-0.60.60.9-0.2
Locomotor activity0.00.00.1-0.20.20.1-0.10.10.1-0.20.00.1-0.2-0.10.1
Locomotor testing distance0.20.30.7-0.90.70.6-0.50.50.5-0.60.50.5-0.5-0.30.7
Locomotor testing rearing0.10.10.3-0.40.2-0.20.5-0.4-0.40.5-0.3-0.50.5-0.00.2
Locomotion in novel chamber2.43.04.61.4-1.4-1.82.2-1.7-1.92.0-1.8-1.61.81.4-1.7
Locomotion in novel chamber post-restriction0.70.91.60.8-1.2-0.90.9-0.8-0.90.9-0.9-0.80.71.3-1.0
Fecal boli incidents, locomotor time 12.32.53.2-1.41.41.7-1.41.81.5-1.51.71.8-1.8-1.51.7
Change in fecal boli incidents, locomotor task1.11.01.80.8-0.9-1.10.8-1.2-1.01.0-1.1-1.21.40.9-0.8
Time >=10cm from walls, locomotor time 10.40.40.8-0.30.60.7-0.50.80.6-0.60.70.8-0.8-0.40.9
Bouts of movement, locomotor time 11.51.62.2-1.21.01.4-1.31.41.5-1.21.51.4-1.1-1.21.0
Total resting periods, locomotor time 12.32.63.1-1.61.31.7-1.71.71.8-1.61.71.6-1.3-1.61.5
Rest time, locomotor task time 10.20.31.0-1.00.50.5-0.40.50.4-0.20.50.5-0.1-0.40.5
Distance moved, locomotor task time 10.30.30.90.6-0.3-0.60.4-0.5-0.50.4-0.6-0.60.31.0-0.6
Vertical activity count, locomotor time 10.40.42.10.7-0.6-0.50.7-0.5-0.40.6-0.4-0.40.40.6-1.4
Time >=10cm from walls, locomotor time 20.10.10.2-0.3-0.20.30.00.30.2-0.00.40.3-0.2-0.20.2
Bouts of movement, locomotor time 21.21.32.10.7-1.5-1.11.2-1.2-1.01.0-1.1-1.21.31.1-1.2
Total resting periods, locomotor time 21.01.01.50.6-1.2-1.01.1-1.0-0.90.9-0.9-1.01.21.0-1.2
Rest time, locomotor task time 20.70.81.8-1.31.10.9-0.90.90.9-0.90.80.8-0.6-0.80.7
Distance moved, locomotor task time 20.00.00.10.2-0.0-0.2-0.1-0.2-0.0-0.0-0.1-0.2-0.10.0-0.0
Vertical activity count, locomotor time 20.40.51.20.3-0.8-0.60.8-0.7-0.60.7-0.6-0.70.60.3-1.1
Light reinforcement 11.93.54.7-1.61.82.0-1.82.01.9-1.91.82.0-2.1-1.52.2
Light reinforcement 22.43.24.6-1.91.71.9-1.51.81.7-1.81.71.9-2.1-1.91.2
Bone: marrow area3.37.19.03.0-2.9-2.92.6-2.8-2.72.6-2.7-2.72.62.6-1.3
Bone: maximum diameter0.51.02.61.6-1.4-1.10.8-0.9-0.90.7-0.9-0.80.71.2-0.7
Bone: maximum force3.15.37.62.8-2.6-2.52.3-2.3-2.32.3-2.2-2.22.31.9-1.8
Bone: maximum moment4.27.29.63.1-2.9-2.92.8-2.7-2.72.7-2.6-2.62.72.3-1.8
Mean time between licks in bursts0.40.53.6-1.90.90.7-0.20.50.4-0.10.50.3-0.1-0.50.6
Mean num. licks in bursts0.30.31.91.4-0.6-0.60.2-0.5-0.30.3-0.3-0.40.40.1-0.6
Cd content in liver0.10.10.2-0.10.00.4-0.50.30.4-0.50.40.4-0.4-0.0-0.5
Co content in liver1.41.72.01.2-1.3-1.31.4-1.3-1.41.3-1.3-1.31.41.4-0.7
Cu content in liver8.710.516.83.0-4.1-3.23.2-3.2-3.23.1-3.0-3.13.13.7-2.9
Fe content in liver0.20.31.5-1.20.50.5-0.60.40.5-0.30.40.4-0.4-0.40.3
K content in liver0.50.50.7-0.4-0.7-0.60.8-0.7-0.80.8-0.7-0.80.80.30.4
Mg content in liver0.20.30.3-0.5-0.6-0.30.6-0.4-0.50.5-0.4-0.50.50.40.5
Mn content in liver0.10.10.2-0.40.1-0.20.1-0.2-0.30.2-0.3-0.30.3-0.20.2
Na content in liver0.30.30.5-0.4-0.6-0.40.7-0.5-0.60.7-0.5-0.60.60.5-0.4
Rb content in liver1.41.85.11.2-1.6-1.21.2-1.2-1.21.3-1.1-1.21.32.3-0.7
Se content in liver1.21.41.9-1.41.41.3-1.21.21.2-1.11.21.2-1.2-1.20.3
Sr content in liver0.20.21.60.00.30.2-0.10.20.2-0.10.40.2-0.2-0.41.2
Zn content in liver1.81.94.2-1.10.91.4-1.41.41.5-1.41.61.5-1.4-0.92.0
Bone: minimum diameter2.24.08.42.9-2.3-2.21.8-2.1-1.81.8-1.9-1.91.91.9-1.4
Time in familiar zone, hab. session 10.30.20.7-0.40.60.4-0.50.30.5-0.50.50.4-0.5-0.80.3
Time in novel zone, hab. session 10.50.41.10.8-0.7-0.50.6-0.4-0.60.6-0.6-0.40.51.1-0.7
Total zone transitions, hab. session 11.21.62.0-1.31.31.4-1.31.41.4-1.31.31.4-1.3-1.01.0
Total locomotion distance, hab. session 12.73.85.0-1.81.92.0-2.01.92.0-2.01.91.9-1.9-1.92.2
Locomotion velocity, hab. session 11.82.53.8-1.71.61.6-1.61.51.5-1.61.51.5-1.4-1.71.9
Time in familiar zone, hab. session 21.51.52.11.4-1.5-1.41.1-1.3-1.31.2-1.3-1.31.11.0-1.0
Time in novel zone, hab. session 20.20.20.6-0.50.80.6-0.20.50.4-0.30.40.4-0.2-0.10.4
Total zone transitions, hab. session 21.82.32.7-1.61.31.6-1.51.51.5-1.61.51.5-1.5-1.51.6
Total locomotion distance, hab. session 22.83.77.1-1.71.91.8-1.81.81.9-1.91.81.8-1.8-2.12.7
Locomotion velocity, hab. session 22.83.77.3-1.81.81.8-1.81.81.8-1.91.81.8-1.8-2.22.7
Novel to familiar place preference ratio0.10.10.80.9-0.1-0.30.2-0.3-0.20.2-0.3-0.20.30.20.1
Novelty place preference0.10.10.60.7-0.1-0.40.3-0.3-0.30.3-0.4-0.30.40.20.2
Time in novel zone, NPP test0.20.20.70.8-0.2-0.50.3-0.5-0.40.5-0.5-0.50.60.40.0
Total zone transitions, NPP test5.47.79.0-3.02.62.9-2.92.82.9-2.82.72.8-2.7-2.62.6
Total locomotion distance, NPP test7.310.013.7-3.13.03.1-3.13.13.1-3.13.13.0-3.0-3.43.7
Locomotion velocity, NPP test7.310.415.6-3.13.03.1-3.13.13.2-3.23.13.1-3.0-3.64.0
Intraocular pressure0.10.20.7-0.40.10.3-0.30.10.2-0.20.30.1-0.00.8-0.8
Delta distance traveled before/after self-admin0.40.51.41.0-0.00.4-0.80.60.7-0.70.70.7-0.5-0.21.2
Delta ambulatory time before/after self-admin0.50.51.61.2-0.20.3-0.90.60.7-0.70.80.7-0.60.01.0
Parametrial fat weight2.44.77.5-1.91.92.1-2.32.22.3-2.22.32.1-2.1-1.82.7
Pavlov. Cond. lever latency0.60.71.5-0.91.20.8-0.80.70.8-0.70.80.7-0.8-1.2-0.5
Pavlov. Cond. magazine entry latency1.62.03.71.9-1.8-1.41.2-1.2-1.31.1-1.4-1.21.11.6-1.5
Pavlov. Cond. change in total contacts2.12.24.01.5-2.0-1.51.3-1.4-1.41.2-1.6-1.41.41.7-1.1
Pavlov. Cond. index score2.53.25.42.2-2.3-1.81.7-1.7-1.71.5-1.8-1.71.62.0-1.1
Pavlov. Cond. latency score2.53.25.32.2-2.3-1.81.7-1.6-1.81.6-1.8-1.61.62.1-0.8
Pavlov. Cond. lever contacts1.21.42.71.2-1.7-1.21.1-1.1-1.21.0-1.2-1.11.11.40.0
Pavlov. Cond. magazine entry number1.01.23.5-1.91.61.1-0.70.90.8-0.71.00.8-0.8-1.20.9
Pavlov. Cond. intertrial magazine entries3.23.95.3-2.32.32.0-2.11.92.0-1.92.01.9-2.0-1.61.3
Pavlov. Cond. lever-magazine prob. diff.2.43.05.22.0-2.3-1.71.6-1.6-1.71.5-1.8-1.61.61.9-1.1
Pavlov. Cond. response bias1.11.32.51.4-1.6-1.20.9-1.1-1.00.9-1.2-1.11.01.3-0.9
Pavlov. Cond. lever latency1.31.72.61.1-0.9-1.41.4-1.5-1.51.5-1.6-1.51.50.9-0.9
Pavlov. Cond. magazine entry latency2.42.83.7-1.51.71.7-1.61.71.8-1.51.91.7-1.7-1.91.2
Pavlov. Cond. change in total contacts0.10.10.60.2-0.60.0-0.10.00.2-0.10.10.1-0.20.3-0.8
Pavlov. Cond. index score2.22.83.9-1.51.41.8-1.61.81.9-1.72.01.8-1.8-1.61.0
Pavlov. Cond. latency score2.02.53.5-1.51.31.7-1.61.71.8-1.61.91.7-1.7-1.61.1
Pavlov. Cond. lever contacts1.92.63.8-1.31.21.7-1.61.71.8-1.71.91.8-1.8-1.31.4
Pavlov. Cond. magazine entry number0.81.01.50.7-0.9-1.10.9-1.0-1.10.9-1.2-1.11.01.1-0.4
Pavlov. Cond. intertrial magazine entries0.00.10.4-0.20.2-0.10.2-0.1-0.2-0.1-0.1-0.1-0.00.30.6
Pavlov. Cond. lever-magazine prob. diff.1.41.82.7-1.31.11.4-1.31.41.5-1.31.71.5-1.4-1.40.7
Pavlov. Cond. response bias1.31.72.7-1.10.91.4-1.31.41.5-1.41.71.4-1.5-1.10.8
Time in closed arm before self-admin0.10.10.5-0.70.4-0.0-0.2-0.1-0.10.1-0.3-0.20.1-0.40.3
Time in closed arm after self-admin0.40.41.10.5-0.6-0.60.1-0.7-0.40.3-0.8-0.70.61.0-0.7
Time in open arm before self-admin1.41.53.11.1-1.4-0.91.5-1.0-1.11.3-0.9-0.91.01.5-1.7
Time in open arm after self-admin0.91.02.0-0.71.21.1-0.21.10.7-0.61.01.1-1.4-1.40.6
Bone: periosteal estimation3.26.611.13.3-3.0-2.82.4-2.6-2.52.4-2.5-2.52.52.4-1.4
Bone: periosteal perimeter2.54.28.12.8-2.2-2.21.9-2.0-2.01.8-2.1-1.91.81.8-1.7
Bone: post-yield work2.43.25.22.3-2.1-1.91.8-1.7-1.81.8-1.7-1.71.71.7-1.1
Progressive ratio test 1 active lever presses2.32.53.7-1.91.01.8-1.71.81.8-1.71.81.7-1.5-0.70.6
Progressive ratio test 1 breakpoint2.12.23.2-1.80.91.7-1.71.71.7-1.71.71.6-1.4-0.60.5
Progressive ratio test 1 inactive lever presses1.92.13.8-0.60.91.5-1.91.71.8-1.71.61.7-1.7-0.70.0
Progressive ratio test 2 active lever presses0.20.21.00.5-0.70.10.10.30.1-0.10.30.3-0.20.8-1.0
Progressive ratio test 2 breakpoint0.20.31.30.6-0.80.00.20.20.00.00.20.2-0.10.8-1.1
Progressive ratio test 2 inactive lever presses0.30.30.90.5-0.20.4-0.40.60.5-0.20.60.6-0.60.3-1.0
Incentive Sensitization - Responses1.61.64.12.0-1.5-1.21.4-0.9-1.21.1-1.0-1.00.91.2-1.4
Incentive Sensitization - Breakpoint2.12.14.42.1-1.7-1.41.6-1.1-1.41.2-1.2-1.21.01.4-1.6
Sum of active levers in priming session hrs 5-60.10.10.6-0.1-0.20.30.60.20.1-0.20.40.3-0.30.3-0.8
Progressive ratio0.20.20.60.1-0.1-0.30.6-0.3-0.30.6-0.2-0.40.70.4-0.5
Food seeking constrained by brief footshock0.40.50.90.0-0.40.8-0.61.00.9-0.51.01.0-0.70.20.7
Seeking ratio, punishment vs. effort0.30.40.90.1-0.20.6-0.70.70.7-0.60.60.7-0.9-0.20.6
Retroperitoneal fat weight1.03.44.6-1.62.01.8-2.11.81.9-1.91.91.8-1.8-1.71.4
Reaction time number correct0.81.21.60.3-1.2-1.21.2-1.2-1.31.2-1.1-1.21.30.9-0.7
Reaction time mean minus median0.40.60.8-0.80.90.8-0.90.70.8-0.90.60.8-0.7-0.8-0.3
Reaction time mean minus median AUC0.30.40.8-0.90.80.7-0.50.60.5-0.60.40.6-0.5-0.5-0.8
Reaction time num false alarms3.54.85.9-1.62.32.2-2.22.32.3-2.42.22.3-2.2-1.82.4
Reaction time num false alarms AUC3.85.26.8-1.72.32.4-2.42.42.4-2.62.32.4-2.5-1.92.0
Reaction time trials correct on left0.81.21.60.3-1.2-1.21.2-1.2-1.31.2-1.1-1.21.30.9-0.7
Reaction time trials on left0.60.91.30.3-1.0-1.01.0-1.1-1.11.0-1.0-1.11.10.7-0.6
Reaction time mean0.00.10.20.10.40.1-0.40.10.3-0.30.20.2-0.2-0.1-0.4
Reaction time mean AUC0.00.10.50.20.1-0.1-0.0-0.2-0.00.0-0.2-0.10.10.0-0.7
Median of all reaction times0.00.00.20.5-0.0-0.2-0.1-0.20.00.1-0.1-0.20.10.2-0.3
Reaction time omissions2.63.54.9-1.02.01.9-2.11.82.1-2.02.01.9-1.8-2.21.4
Reaction time false alarm rate3.75.26.8-1.42.32.4-2.42.52.5-2.62.32.5-2.6-1.81.9
Reaction time premature initiation rate0.71.01.7-0.10.70.9-1.31.11.2-1.21.21.1-1.2-0.30.8
Reaction time premature initiations0.10.10.30.2-0.00.1-0.50.30.4-0.40.40.2-0.40.10.3
Std. dev. reaction times0.40.50.8-0.70.80.7-0.90.70.8-0.80.60.7-0.6-0.8-0.3
Reaction time trials completed0.60.91.30.3-1.0-1.01.0-1.1-1.11.0-1.0-1.11.10.7-0.6
Reaction time trials AUC0.81.21.60.4-1.2-1.21.2-1.2-1.31.2-1.1-1.21.30.9-0.7
Run reversals in cocaine runway, females0.20.20.90.9-0.5-0.50.3-0.3-0.30.3-0.3-0.40.20.1-0.3
Run reversals in cocaine runway, males0.20.20.8-0.60.80.3-0.30.20.1-0.3-0.10.2-0.4-0.9-0.3
Latency to leave start box in cocaine runway0.00.00.20.00.10.1-0.00.20.0-0.40.00.1-0.10.20.0
Latency to leave start box in cocaine runway, F0.80.91.5-1.01.11.0-0.91.10.9-1.20.80.9-0.9-0.70.6
Latency to leave start box in cocaine runway, M1.51.52.51.6-1.4-1.31.1-1.1-1.11.0-1.1-1.11.01.5-1.1
Std. dev. time between licks in bursts0.40.51.9-1.20.70.6-0.10.50.2-0.10.40.4-0.4-0.71.4
Total sessions with >9 infusions0.91.02.30.5-1.3-0.71.0-0.6-0.81.0-0.7-0.71.01.5-1.3
Short access day 1 total inactive lever presses0.20.21.20.5-0.40.3-0.20.30.4-0.00.50.50.00.3-1.1
Short access day 10 total inactive lever presses0.80.93.31.8-1.2-1.00.4-1.0-0.70.7-0.8-0.80.70.9-0.9
Short access day 1 total infusions0.20.20.50.1-0.00.3-0.50.60.5-0.70.40.4-0.4-0.1-0.1
Short access day 10 total infusions1.11.22.0-1.00.71.3-1.21.41.3-1.41.31.3-1.1-0.20.2
Short access total infusions0.10.10.3-0.2-0.20.3-0.40.40.3-0.60.30.3-0.20.5-0.2
Short access day 1 locomotion0.50.50.7-0.70.60.8-0.80.80.8-0.80.80.7-0.4-0.80.2
Short access day 10 total locomotion0.80.91.7-0.60.81.0-1.21.01.1-1.31.01.0-0.8-0.80.7
Short access total locomotion0.90.91.5-1.20.91.1-0.91.01.0-1.11.01.0-0.6-0.80.5
One hour access (0.3 mA shock)3.44.06.02.0-2.1-1.82.1-1.7-1.92.1-1.7-1.72.02.2-2.4
Compulsive drug intake2.02.03.61.9-1.7-1.31.5-1.3-1.41.5-1.3-1.11.21.7-0.8
One hour access (shock baseline)1.61.85.50.8-1.2-1.21.4-1.2-1.21.3-1.2-1.21.41.3-2.4
Social response proportion1.61.73.5-0.20.91.2-1.91.51.6-1.61.51.4-1.2-1.30.5
Social responses2.32.94.3-1.71.81.6-1.81.71.7-1.71.61.5-1.5-2.11.6
Social time1.31.83.4-0.51.21.1-1.51.41.3-1.51.31.2-1.3-1.81.5
Soleus weight0.61.92.61.3-1.2-1.41.4-1.4-1.41.5-1.3-1.41.40.9-1.6
Bone: stiffness4.77.512.13.5-3.3-2.92.4-2.8-2.62.6-2.7-2.72.72.3-1.9
Tibialis anterior weight4.415.119.02.8-2.8-4.04.2-3.9-4.14.1-4.4-4.04.03.7-4.2
Time to tail flick, vehicle, before self-admin0.10.10.4-0.30.60.20.20.20.1-0.10.20.2-0.2-0.4-0.2
Time to tail flick, vehicle, after self-admin0.70.71.21.1-0.7-1.00.7-1.0-0.80.7-0.9-1.01.10.2-0.2
Time to tail flick, test, before self-admin2.72.63.9-1.21.91.6-1.61.71.6-2.01.51.6-1.8-1.80.8
Time to tail flick, test, after self-admin1.11.23.31.8-0.9-1.20.7-1.2-1.00.9-1.1-1.10.90.9-0.9
Delta time to tail flick, vehicle, before/after SA1.21.22.01.3-1.4-1.20.9-1.2-1.00.9-1.0-1.21.30.9-0.2
Delta time to tail flick, test, before/after SA3.53.15.52.3-1.9-1.91.1-2.0-1.51.9-1.7-1.81.81.8-0.9
Tibia length0.51.32.61.6-1.2-1.31.1-1.1-1.11.2-1.0-1.01.01.3-0.8
Ambulatory time before self-admin0.10.10.5-0.4-0.2-0.0-0.0-0.10.0-0.1-0.0-0.10.10.4-0.7
Ambulatory time after self-admin0.40.41.81.4-1.1-0.4-0.1-0.1-0.1-0.1-0.0-0.10.11.1-0.9
Bone: tissue strength2.12.02.21.3-1.5-1.41.3-1.4-1.41.4-1.5-1.51.51.5-1.5
Total heroin consumption2.93.45.72.4-2.1-1.82.2-1.8-1.81.8-1.4-1.71.81.9-1.2
Bone: trabecular number0.20.31.21.1-0.7-0.60.4-0.6-0.40.5-0.5-0.60.50.2-0.1
Bone: trabecular spacing0.10.10.90.0-0.30.00.10.10.00.00.10.10.11.0-0.6
Bone: trabecular thickness0.10.10.30.10.50.2-0.40.30.3-0.40.20.3-0.4-0.50.3
Bone: trabecular tissue density0.10.20.50.10.30.5-0.10.70.4-0.30.40.7-0.3-0.30.2
Water consumed over 24 hours0.30.40.60.2-0.4-0.70.7-0.7-0.70.7-0.6-0.80.60.70.1
Number of responses in last shaping day3.53.65.1-1.62.22.0-2.02.02.1-1.82.12.1-1.5-2.30.7