Hub : Genes

Spryd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Spryd3 0.28 0.11 0.0e+00 0.17 0.16 0.17 0.17 3.7e-18 1.5e-17 3.2e-18 4.6e-18
2 IL mRNA stability Spryd3 0.38 0.17 4.4e-04 0.19 0.08 0.12 0.16 2.1e-05 4.9e-03 8.3e-04 1.5e-04
3 Eye gene expression Spryd3 0.42 0.19 7.4e-04 0.16 0.13 0.24 0.26 1.9e-03 4.8e-03 1.2e-04 7.5e-05
4 PL mRNA stability Spryd3 0.11 0.08 2.1e-05 0.04 0.05 0.05 0.05 2.3e-05 6.1e-06 8.5e-06 6.7e-06
5 BLA gene expression Spryd3 0.11 0.03 2.3e-06 0.11 0.08 0.06 0.12 3.0e-06 4.8e-05 4.9e-04 1.1e-06
6 NAcc mRNA stability Spryd3 0.08 0.05 6.6e-06 0.04 0.03 0.03 0.04 2.9e-07 1.8e-05 5.1e-06 3.2e-07
7 NAcc gene expression Spryd3 0.2 0.01 0.0e+00 0.36 0.38 0.38 0.38 4.8e-57 6.4e-61 1.2e-61 2.5e-61
8 BLA mRNA stability Spryd3 0.06 0.05 2.8e-03 0.05 0.02 0 0.04 1.0e-03 1.9e-02 3.0e-01 5.9e-03
9 PL gene expression Spryd3 0.11 0.02 1.6e-14 0.14 0.14 0.14 0.14 2.4e-15 2.5e-15 6.9e-15 2.0e-15
10 IL gene expression Spryd3 0.43 0.14 1.7e-06 0.22 0.21 0.23 0.24 6.6e-06 9.0e-06 3.5e-06 1.5e-06
11 Brain gene expression Spryd3 0.22 0.1 8.0e-11 0.13 0.12 0.13 0.14 2.7e-12 1.6e-11 2.8e-12 1.4e-12
12 Brain mRNA stability Spryd3 0.23 0.09 5.3e-15 0.18 0.17 0.18 0.18 5.9e-17 7.6e-16 1.7e-16 8.9e-17
13 Liver gene expression Spryd3 0.1 0.05 5.2e-09 0.08 0.08 0.08 0.07 6.1e-09 3.6e-09 5.1e-09 1.0e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.83.34.52.02.1-1.9-2.1-2.01.81.81.9-1.7-1.6-1.61.61.3
Area under the delay curve0.30.51.10.80.9-1.1-0.7-0.70.70.70.7-0.5-0.5-0.50.50.6
BMI with tail2.37.912.03.13.5-2.6-3.0-3.02.62.83.0-2.5-2.7-2.52.62.4
BMI without tail0.63.24.12.01.7-1.4-1.9-1.82.01.91.8-1.8-1.8-1.81.81.6
Body weight0.83.75.02.12.1-1.7-2.2-2.01.91.92.0-1.9-1.9-1.91.91.3
Weight adjusted by age0.31.02.6-0.9-1.10.70.80.9-1.0-1.1-1.00.90.80.9-0.9-1.6
Bone surface3.46.78.12.92.8-2.7-2.8-2.72.72.72.7-2.5-2.4-2.42.32.2
Bone volume3.16.17.22.62.7-2.6-2.6-2.62.62.62.5-2.3-2.3-2.32.32.2
Breakpoint value in progressive ratio session1.22.23.31.61.8-1.4-1.3-1.71.51.51.5-1.4-1.3-1.41.11.6
Number of licking bursts0.00.10.7-0.2-0.80.10.40.40.1-0.1-0.3-0.1-0.1-0.1-0.00.2
Context. condit. distance diff. score0.30.31.10.50.7-0.6-0.3-0.60.40.60.6-0.6-0.4-0.50.31.0
Locomotion velocity, session 15.46.110.2-2.9-3.22.92.32.6-2.3-2.4-2.52.22.22.1-2.0-2.3
Locomotion distance, session 14.15.29.1-2.5-3.02.52.22.5-1.9-2.2-2.42.12.02.0-1.9-2.1
Locomotion velocity, session 21.82.24.3-1.6-2.11.90.91.5-1.2-1.4-1.41.21.31.1-1.1-2.0
Locomotion distance, session 24.05.77.3-2.4-2.72.52.42.5-2.2-2.4-2.52.32.32.3-2.2-2.2
Locomotion velocity, session 32.02.33.8-1.8-1.91.91.21.5-1.3-1.4-1.51.51.41.4-1.0-1.6
Locomotion distance, session 31.21.42.5-1.4-1.61.60.91.1-1.1-1.1-1.11.11.11.1-0.8-1.2
Stereotopy head waving bouts, day 31.41.62.41.31.3-1.6-1.0-1.21.31.31.2-1.2-1.3-1.21.21.4
Stereotopy head waving duration, day 30.40.50.60.70.6-0.7-0.7-0.60.80.70.7-0.7-0.7-0.70.70.7
Locomotion velocity, session 70.80.91.5-1.1-1.00.91.21.0-1.0-0.9-1.00.90.90.9-0.9-0.2
Locomotion distance, session 72.63.35.9-2.0-2.42.01.72.0-1.5-1.7-1.91.51.71.5-1.8-1.7
Stereotopy head waving bouts, day 71.21.42.51.21.3-1.6-0.7-1.11.01.11.1-1.0-1.3-1.01.21.5
Stereotopy head waving duration, day 71.61.92.81.41.5-1.7-1.1-1.41.21.31.3-1.2-1.4-1.21.51.6
Locomotion velocity, session 80.00.00.2-0.2-0.20.10.30.1-0.4-0.2-0.10.10.10.1-0.10.3
Locomotion distance, session 82.13.14.3-1.9-2.11.91.81.8-1.6-1.7-1.81.61.81.6-1.7-1.4
Degree of sensitization distance0.10.10.3-0.2-0.30.00.40.4-0.1-0.2-0.40.10.30.2-0.6-0.1
Degree of sensitization stereotypy0.91.01.70.91.1-1.3-0.7-0.90.80.90.9-0.9-1.1-0.91.11.3
Conditioned locomotion0.80.91.1-0.9-0.81.10.90.9-0.9-0.9-0.91.01.01.0-1.0-0.7
Cocaine response after cond. corrected1.31.92.3-1.4-1.51.31.41.5-1.3-1.4-1.51.41.21.4-1.3-1.4
Cocaine response after cond. not corrected1.31.92.4-1.4-1.21.31.41.4-1.5-1.4-1.41.41.31.4-1.2-1.4
Cocaine response before conditioning0.00.00.2-0.20.30.20.2-0.0-0.5-0.20.10.20.20.2-0.10.1
Saline control response0.20.30.7-0.5-0.10.50.80.5-0.8-0.6-0.50.60.70.6-0.80.0
Bone: connectivity density0.20.41.00.61.0-0.7-0.7-0.80.30.50.7-0.5-0.4-0.40.40.3
Bone: cortical apparent density1.52.33.2-1.4-1.61.11.81.7-1.4-1.6-1.71.51.51.5-1.8-1.2
Bone: cortical area1.42.23.61.71.9-1.6-1.6-1.61.51.51.5-1.4-1.3-1.31.11.1
Bone: cortical porosity0.10.10.3-0.3-0.20.60.10.2-0.4-0.3-0.20.30.50.3-0.4-0.4
Bone: cortical porosity0.20.20.4-0.4-0.20.70.30.3-0.5-0.4-0.30.50.60.5-0.5-0.5
Bone: cortical thickness0.10.10.20.40.5-0.4-0.4-0.30.30.30.3-0.4-0.2-0.3-0.1-0.0
Bone: cortical thickness2.22.64.8-1.4-1.21.71.31.5-1.6-1.7-1.61.61.81.7-1.8-2.2
Bone: cortical tissue density1.62.53.3-1.5-1.71.21.81.8-1.5-1.6-1.81.51.51.6-1.8-1.3
Condit. Reinf. active minus inactive responses0.80.91.1-1.0-0.81.00.90.9-1.0-0.9-0.90.91.00.9-1.0-0.7
Condit. Reinf. active-inactive response ratio0.50.50.7-0.7-0.50.80.60.6-0.8-0.7-0.60.70.80.7-0.8-0.7
Condit. Reinf. active responses1.92.52.9-1.6-1.51.71.51.5-1.5-1.5-1.61.61.71.6-1.7-1.4
Condit. Reinf. inactive responses2.22.93.3-1.7-1.71.81.71.8-1.5-1.7-1.81.81.71.8-1.7-1.5
Incentive salience index mean0.30.40.6-0.6-0.50.70.70.6-0.7-0.7-0.60.70.70.7-0.8-0.5
Condit. Reinf. lever presses0.00.00.10.1-0.2-0.10.30.1-0.0-0.1-0.20.10.00.1-0.10.1
Condit. Reinf. active minus inactive responses0.20.30.50.60.6-0.7-0.3-0.50.40.50.5-0.5-0.5-0.50.40.7
Condit. Reinf. active-inactive response ratio0.10.20.30.60.6-0.5-0.4-0.50.30.50.4-0.5-0.4-0.40.40.5
Condit. Reinf. active responses0.20.30.90.50.5-0.8-0.1-0.40.40.50.4-0.5-0.5-0.50.41.0
Condit. Reinf. inactive responses0.10.20.4-0.5-0.50.20.70.5-0.3-0.4-0.40.40.20.3-0.40.1
Condit. Reinf. lever presses0.30.50.8-0.7-0.30.70.90.7-0.7-0.6-0.60.70.90.8-0.9-0.2
Condit. Reinf. lever reinforcers received0.00.00.3-0.00.1-0.20.40.1-0.1-0.0-0.00.0-0.00.0-0.10.5
Conditioned reinforcement - actives0.10.41.4-0.4-1.2-0.40.90.5-0.5-0.6-0.50.60.60.6-0.60.2
Conditioned reinforcement - inactives0.92.53.8-1.3-1.20.61.71.4-1.8-1.7-1.51.81.91.9-2.0-1.2
Conditioned locomotion0.10.10.80.4-0.5-0.90.2-0.10.2-0.10.00.00.20.1-0.20.5
Patch foraging indifference point 0 sec0.72.13.8-1.7-2.01.51.71.6-1.6-1.5-1.51.11.11.1-1.2-0.9
Patch foraging indifference point AUC0.71.62.4-1.5-1.61.21.51.5-1.1-1.2-1.41.21.11.2-1.0-0.8
Delay disc. indifference point, 0s delay0.00.00.10.0-0.2-0.2-0.10.10.0-0.1-0.1-0.0-0.1-0.00.0-0.3
Delay disc. indifference point, 16s delay0.10.20.80.40.9-0.6-0.5-0.40.30.40.4-0.1-0.1-0.10.10.4
Delay disc. indifference point, 2s delay2.22.54.61.71.3-2.2-1.2-1.41.61.51.4-1.5-1.7-1.51.61.8
Delay disc. indifference point, 24s delay0.10.20.40.60.4-0.6-0.4-0.60.50.50.5-0.3-0.3-0.30.50.5
Delay disc. indifference point, 4s delay0.70.81.31.01.1-1.1-0.8-0.80.90.90.8-0.8-0.7-0.70.60.9
Delay disc. indifference point, 8s delay0.10.20.40.50.6-0.5-0.6-0.30.40.40.4-0.3-0.2-0.30.30.3
Indifference point function ln k1.44.35.62.32.2-2.0-2.4-2.32.02.12.2-2.2-1.9-2.11.91.4
Indifference point function log k1.44.35.62.32.2-2.0-2.4-2.32.02.12.2-2.2-1.9-2.11.91.4
Patch foraging total patch changes 0 sec0.92.54.6-1.9-2.11.71.81.8-1.7-1.6-1.71.31.31.2-1.2-1.2
Patch foraging total patch changes 12 sec3.64.86.9-2.4-2.42.12.62.4-2.3-2.2-2.32.11.92.0-2.0-1.3
Patch foraging total patch changes 18 sec2.25.17.6-2.6-2.82.32.62.5-2.3-2.3-2.42.11.92.0-1.9-1.4
Patch foraging total patch changes 24 sec0.31.12.2-1.3-1.50.91.51.3-1.0-1.0-1.10.80.60.7-0.6-0.2
Patch foraging total patch changes 6 sec1.52.57.8-2.0-2.81.61.91.9-1.3-1.5-1.81.10.81.0-0.8-1.0
Patch foraging time to switch 0 sec0.00.10.2-0.3-0.40.10.50.4-0.3-0.4-0.40.30.20.3-0.3-0.4
Patch foraging water rate 0 sec0.10.20.30.40.5-0.4-0.5-0.50.30.50.5-0.5-0.3-0.50.40.6
Patch foraging water rate 12 sec0.00.10.20.30.40.0-0.5-0.40.10.30.5-0.4-0.2-0.40.30.2
Patch foraging water rate 18 sec0.00.00.1-0.10.00.00.20.0-0.3-0.1-0.0-0.00.0-0.0-0.00.2
Patch foraging water rate 24 sec0.50.71.30.90.8-0.9-0.7-0.80.80.90.9-0.9-0.8-0.90.71.1
Patch foraging water rate 6 sec1.11.63.91.22.0-1.2-1.3-1.50.81.21.5-1.0-0.9-1.01.21.2
Seeking ratio, delayed vs. immediate footshock0.20.20.7-0.1-0.10.10.40.4-0.2-0.5-0.40.70.70.7-0.9-0.5
Distance traveled before self-admin0.00.10.40.20.2-0.7-0.3-0.10.20.20.2-0.3-0.2-0.30.10.2
Distance traveled after self-admin0.10.20.60.20.8-0.70.1-0.4-0.30.10.30.20.40.2-0.30.6
Extensor digitorum longus weight6.626.231.25.44.4-5.6-5.0-5.05.35.14.9-5.3-5.4-5.35.24.5
Bone: elastic displacement1.21.52.3-1.2-1.51.51.11.3-1.0-1.1-1.21.11.31.1-1.2-1.0
Bone: elastic work0.30.41.3-0.5-1.01.00.20.6-0.3-0.5-0.60.40.70.5-0.6-1.1
Bone: endosteal estimation3.48.39.33.13.0-2.8-3.0-3.02.93.03.0-2.7-2.7-2.72.82.5
Bone: endosteal perimeter3.07.39.03.03.0-2.7-2.9-2.92.82.82.8-2.5-2.5-2.52.52.2
Epididymis fat weight0.10.71.6-0.8-0.01.00.10.3-1.1-0.8-0.40.91.11.0-0.7-1.3
Delta time in closed arm before/after self-admin0.60.61.30.71.2-0.6-0.6-0.90.40.70.9-0.7-0.7-0.60.61.1
Delta time in open arm before/after self-admin2.22.64.4-1.6-1.41.41.21.5-1.8-1.7-1.51.81.71.7-1.5-2.1
Diff in mean of infusions in LGA sessions0.10.10.30.50.1-0.1-0.5-0.60.30.20.3-0.3-0.3-0.30.1-0.1
Delay discount exponential model param0.60.91.7-1.0-1.11.31.00.9-0.9-0.9-0.90.70.70.7-0.8-0.8
Extinction: sum of active levers before priming3.45.17.02.21.8-1.3-2.5-2.32.62.42.2-2.6-2.5-2.52.31.7
Active lever presses in extinction session 60.60.61.00.91.0-0.5-0.8-0.50.90.90.7-0.9-0.6-0.80.50.9
Bone: final force3.65.97.82.52.5-2.4-2.8-2.62.42.52.5-2.5-2.3-2.52.31.7
Bone: final moment4.77.79.92.92.7-2.7-3.1-2.92.82.82.9-2.9-2.6-2.82.62.0
Food consumed during 24 hour testing period0.10.10.40.30.7-0.2-0.4-0.50.10.30.4-0.2-0.2-0.10.30.3
Glucose0.40.71.5-0.6-1.20.70.71.0-0.6-0.8-1.00.70.80.7-0.9-0.8
Heart weight0.20.31.70.51.3-0.3-0.5-0.80.10.30.60.00.10.1-0.00.1
Delay discount hyperbolic model param0.71.02.0-1.1-1.11.41.00.9-1.0-1.0-0.90.80.80.8-0.9-0.9
Intermittent access intake day 1-15 change0.00.10.20.20.2-0.1-0.2-0.40.20.30.3-0.2-0.1-0.20.20.4
Intermittent access intake escalation0.00.10.20.20.2-0.1-0.3-0.40.30.30.3-0.2-0.2-0.20.30.2
Intermittent access intake escalation 20.00.00.0-0.00.20.1-0.1-0.1-0.1-0.00.1-0.00.00.0-0.0-0.0
Intermitt. access day 1 inactive lever presses0.00.20.70.20.8-0.80.1-0.50.10.20.30.0-0.20.00.10.5
Intermitt. access day 15 inactive lever presses0.00.10.10.10.3-0.3-0.0-0.3-0.2-0.10.10.30.30.3-0.2-0.2
Intermitt. access escalation Index0.30.81.60.70.1-1.2-0.4-0.61.10.90.6-1.0-1.2-1.11.01.3
Intermittent access day 1 total infusions0.41.22.3-0.9-1.00.31.51.0-1.3-1.1-1.11.31.21.3-1.2-0.3
Intermittent access day 15 total infusions0.40.92.2-0.9-1.50.31.30.9-1.0-1.0-1.00.90.80.9-0.9-0.3
Intermittent access terminal intake (last 3 days)0.40.82.0-0.7-1.1-0.11.40.8-1.0-0.9-0.90.90.80.9-0.90.1
Intermittent access total infusions0.60.71.8-0.6-1.0-0.21.30.8-0.9-0.8-0.80.80.70.8-0.80.2
Intermittent access day 1 locomotion0.10.20.7-0.3-0.6-0.10.90.3-0.4-0.4-0.40.40.40.5-0.40.4
Intermittent access day 15 total locomotion0.00.10.20.40.5-0.3-0.3-0.30.20.30.4-0.10.1-0.00.00.4
Intermittent access total locomotion0.00.10.2-0.0-0.1-0.40.4-0.0-0.2-0.1-0.00.20.20.2-0.10.5
Intermittent access standard deviation0.31.42.0-1.0-0.80.71.21.2-1.1-1.2-1.21.21.41.3-1.4-1.1
Left kidney weight0.00.10.30.30.3-0.0-0.5-0.30.10.00.10.00.20.1-0.2-0.5
Right kidney weight0.21.22.71.11.1-0.7-1.6-1.31.21.11.1-1.1-1.0-1.10.90.1
Cocaine induced anxiety0.82.23.01.41.0-1.4-1.6-1.21.71.61.4-1.7-1.5-1.61.61.4
Post-drug Anxiety2.02.33.11.31.8-1.1-1.6-1.41.51.61.6-1.6-1.4-1.51.51.6
Baseline Anxiety0.40.61.1-0.60.31.00.50.4-1.1-0.7-0.60.90.90.9-0.9-0.9
Tail length0.21.12.1-1.1-1.51.11.01.2-0.7-1.0-1.21.01.11.0-1.0-0.8
Length with tail0.00.10.3-0.3-0.40.30.10.3-0.3-0.3-0.40.20.30.2-0.2-0.6
Length without tail0.21.01.71.11.3-1.2-1.2-1.10.70.91.1-0.9-0.8-0.90.90.5
Times rat made contact with spout0.50.60.90.50.8-0.5-0.9-0.90.40.70.9-0.8-0.7-0.80.90.6
Lifetime Intake0.40.51.5-0.6-0.7-0.31.20.6-0.7-0.6-0.60.70.60.7-0.70.4
Liver weight, left5.810.012.63.43.5-3.0-3.5-3.53.13.23.4-2.9-2.9-2.93.02.7
Liver weight, right0.40.71.41.01.2-1.0-1.2-1.10.60.71.0-0.8-0.6-0.70.60.1
Locomotor activity0.00.00.1-0.2-0.40.30.10.20.0-0.0-0.1-0.2-0.1-0.2-0.0-0.1
Locomotor testing distance0.00.10.6-0.4-0.80.50.30.4-0.1-0.1-0.3-0.10.1-0.2-0.1-0.0
Locomotor testing rearing0.00.10.2-0.1-0.40.2-0.30.10.30.2-0.1-0.4-0.2-0.40.2-0.2
Locomotion in novel chamber5.16.97.82.62.4-2.6-2.7-2.52.72.72.6-2.7-2.8-2.72.82.3
Locomotion in novel chamber post-restriction0.10.20.80.40.2-0.50.1-0.30.50.40.2-0.3-0.5-0.30.40.9
Fecal boli incidents, locomotor time 11.02.63.2-1.5-1.51.61.61.5-1.8-1.7-1.51.71.81.7-1.5-1.6
Change in fecal boli incidents, locomotor task0.70.81.50.70.4-0.7-0.9-0.71.20.90.8-1.0-1.0-1.00.80.8
Time >=10cm from walls, locomotor time 10.20.30.6-0.5-0.10.60.60.5-0.7-0.6-0.50.60.60.6-0.5-0.4
Bouts of movement, locomotor time 11.41.92.5-1.3-1.41.31.31.5-1.1-1.4-1.41.41.41.4-1.6-1.2
Total resting periods, locomotor time 12.42.83.6-1.7-1.91.81.51.7-1.4-1.7-1.61.61.71.7-1.8-1.6
Rest time, locomotor task time 10.40.62.4-0.8-1.50.80.60.9-0.2-0.6-0.80.50.60.5-0.5-0.6
Distance moved, locomotor task time 10.10.30.80.40.8-0.6-0.2-0.50.40.50.5-0.4-0.6-0.40.50.9
Vertical activity count, locomotor time 10.10.31.40.80.9-1.2-0.2-0.50.40.40.4-0.4-0.4-0.40.20.6
Time >=10cm from walls, locomotor time 20.00.10.2-0.1-0.20.20.30.4-0.3-0.3-0.40.10.30.2-0.4-0.1
Bouts of movement, locomotor time 20.41.31.61.21.2-1.2-1.0-0.91.21.21.0-1.3-1.2-1.21.01.3
Total resting periods, locomotor time 20.31.11.51.11.2-1.2-0.8-0.81.11.10.9-1.1-1.1-1.10.81.2
Rest time, locomotor task time 20.50.81.7-1.0-1.30.91.01.1-0.7-0.9-0.90.90.80.8-0.7-0.6
Distance moved, locomotor task time 20.00.00.1-0.00.3-0.1-0.3-0.10.10.10.0-0.2-0.1-0.20.0-0.1
Vertical activity count, locomotor time 20.20.40.90.60.4-0.9-0.6-0.40.70.60.4-0.7-0.6-0.70.50.2
Light reinforcement 10.73.14.2-1.8-1.91.62.01.9-1.7-1.8-1.91.61.61.6-1.8-1.3
Light reinforcement 21.53.44.2-2.0-2.01.91.92.0-1.8-1.9-2.01.61.61.5-1.7-1.9
Bone: marrow area3.38.09.03.03.0-2.8-3.0-3.02.92.92.9-2.6-2.7-2.72.82.5
Bone: maximum diameter1.12.23.21.71.8-1.7-1.4-1.51.51.51.5-1.3-1.3-1.31.21.5
Bone: maximum force2.75.46.82.52.0-2.3-2.5-2.32.62.42.3-2.3-2.3-2.32.21.8
Bone: maximum moment3.76.98.82.82.3-2.5-2.9-2.63.02.72.6-2.7-2.6-2.72.52.1
Mean time between licks in bursts0.10.42.1-0.9-1.50.70.50.7-0.3-0.4-0.60.10.1-0.00.0-0.3
Mean num. licks in bursts0.10.31.40.51.2-0.3-0.9-0.80.10.40.8-0.2-0.2-0.20.50.0
Cd content in liver0.10.20.3-0.3-0.50.50.50.3-0.3-0.3-0.40.40.50.5-0.5-0.0
Co content in liver0.60.71.70.90.3-0.7-0.8-0.71.30.90.7-0.9-0.8-0.90.60.8
Cu content in liver7.99.412.53.13.5-3.3-2.8-3.22.83.03.2-2.9-2.9-2.92.83.2
Fe content in liver0.20.20.50.4-0.1-0.4-0.4-0.20.60.50.3-0.7-0.5-0.70.50.6
K content in liver1.31.32.31.00.7-1.0-1.3-0.91.51.31.0-1.3-1.1-1.31.10.9
Mg content in liver1.11.21.90.90.7-1.0-1.1-0.91.41.21.0-1.3-1.0-1.31.01.1
Mn content in liver0.10.10.5-0.4-0.70.40.00.3-0.0-0.1-0.3-0.3-0.1-0.3-0.0-0.2
Na content in liver1.92.12.91.41.3-1.4-1.5-1.21.51.51.4-1.7-1.4-1.71.31.4
Rb content in liver1.72.03.91.61.3-1.5-1.1-1.31.71.51.3-1.2-1.2-1.21.12.0
Se content in liver0.30.40.5-0.6-0.70.70.60.7-0.5-0.6-0.60.40.70.4-0.7-0.6
Sr content in liver0.10.10.1-0.1-0.10.2-0.4-0.10.10.10.2-0.3-0.2-0.30.2-0.4
Zn content in liver0.50.61.0-0.8-0.30.70.80.6-0.9-0.8-0.61.01.01.0-1.0-0.6
Bone: minimum diameter2.54.86.82.42.6-2.2-2.3-2.42.12.22.3-2.1-2.0-2.01.81.9
Time in familiar zone, hab. session 10.10.10.5-0.2-0.10.4-0.00.2-0.1-0.2-0.20.20.30.2-0.3-0.7
Time in novel zone, hab. session 10.20.20.90.40.3-0.70.0-0.30.20.30.3-0.3-0.4-0.30.21.0
Total zone transitions, hab. session 11.21.62.5-1.3-1.31.01.61.4-1.3-1.3-1.41.31.11.3-1.2-0.9
Total locomotion distance, hab. session 12.73.84.4-2.1-1.82.11.91.9-2.0-2.0-1.92.02.02.0-2.0-1.8
Locomotion velocity, hab. session 11.82.63.2-1.8-1.71.81.51.6-1.5-1.6-1.61.61.51.6-1.5-1.7
Time in familiar zone, hab. session 21.82.12.91.41.1-1.3-1.7-1.51.51.51.5-1.5-1.4-1.51.51.0
Time in novel zone, hab. session 20.30.40.8-0.6-0.60.40.90.7-0.6-0.6-0.70.60.50.6-0.7-0.1
Total zone transitions, hab. session 21.52.02.2-1.3-1.51.41.41.4-1.4-1.4-1.41.51.31.5-1.3-1.4
Total locomotion distance, hab. session 22.43.14.1-1.7-1.51.91.51.6-1.8-1.8-1.71.91.81.8-1.6-2.0
Locomotion velocity, hab. session 22.23.04.5-1.7-1.51.91.41.6-1.8-1.8-1.61.91.71.8-1.6-2.1
Novel to familiar place preference ratio0.00.00.30.10.5-0.2-0.1-0.2-0.10.10.2-0.1-0.2-0.00.20.1
Novelty place preference0.00.00.10.20.4-0.2-0.2-0.20.00.20.2-0.1-0.2-0.10.20.2
Time in novel zone, NPP test0.10.10.30.30.5-0.4-0.3-0.40.20.30.4-0.3-0.4-0.30.40.4
Total zone transitions, NPP test5.37.88.8-3.0-3.02.82.92.9-2.7-2.8-2.92.82.62.7-2.5-2.6
Total locomotion distance, NPP test7.09.711.5-3.3-3.03.42.93.1-3.0-3.2-3.13.23.13.1-2.9-3.4
Locomotion velocity, NPP test7.010.012.4-3.3-3.03.52.83.1-3.0-3.2-3.13.23.13.2-2.9-3.5
Intraocular pressure0.20.41.0-0.6-0.70.51.00.8-0.6-0.5-0.70.40.60.4-0.60.5
Delta distance traveled before/after self-admin0.50.51.3-0.50.50.90.50.1-1.0-0.6-0.30.91.10.9-0.8-0.4
Delta ambulatory time before/after self-admin0.20.41.0-0.30.90.50.4-0.2-0.9-0.4-0.10.81.00.8-0.7-0.1
Parametrial fat weight0.30.71.0-1.0-0.70.90.90.9-0.7-0.6-0.70.81.00.8-0.9-0.0
Pavlov. Cond. lever latency0.60.71.6-0.9-0.51.20.40.6-0.9-0.8-0.60.91.00.8-0.8-1.3
Pavlov. Cond. magazine entry latency1.21.62.51.30.8-1.6-0.9-1.01.31.21.1-1.3-1.5-1.31.41.5
Pavlov. Cond. change in total contacts2.12.33.61.61.4-1.9-1.1-1.41.41.51.4-1.4-1.7-1.41.61.8
Pavlov. Cond. index score2.32.94.71.91.3-2.2-1.3-1.51.71.71.5-1.7-1.9-1.71.72.0
Pavlov. Cond. latency score2.43.04.91.91.4-2.2-1.2-1.51.71.71.5-1.7-1.9-1.71.72.1
Pavlov. Cond. lever contacts0.81.01.71.00.6-1.3-0.6-0.81.01.00.8-1.0-1.2-1.01.11.3
Pavlov. Cond. magazine entry number0.70.91.7-1.1-0.61.30.60.8-1.0-0.9-0.80.91.20.9-1.1-1.2
Pavlov. Cond. intertrial magazine entries3.13.74.7-2.2-1.72.21.91.9-1.9-1.9-1.81.92.01.9-1.9-1.6
Pavlov. Cond. lever-magazine prob. diff.2.32.84.61.81.2-2.1-1.2-1.41.71.61.5-1.7-1.9-1.61.72.0
Pavlov. Cond. response bias0.60.71.20.90.4-1.1-0.5-0.60.90.80.7-0.8-1.0-0.81.01.0
Pavlov. Cond. lever latency1.62.32.91.51.1-1.6-1.6-1.51.71.51.4-1.5-1.7-1.51.71.1
Pavlov. Cond. magazine entry latency3.04.25.5-2.1-1.92.31.82.0-2.1-2.1-2.02.02.12.0-2.0-2.3
Pavlov. Cond. change in total contacts0.00.10.2-0.10.3-0.10.50.1-0.5-0.2-0.10.20.10.2-0.30.2
Pavlov. Cond. index score2.43.84.5-2.0-1.62.11.91.9-2.1-2.0-1.91.92.11.9-2.0-1.8
Pavlov. Cond. latency score2.43.94.6-2.0-1.72.11.91.9-2.1-2.0-1.91.92.01.9-2.0-1.9
Pavlov. Cond. lever contacts2.13.14.0-1.8-1.31.91.81.7-1.9-1.8-1.71.72.01.8-1.9-1.4
Pavlov. Cond. magazine entry number1.52.02.71.41.1-1.5-1.3-1.31.61.51.3-1.4-1.5-1.41.51.4
Pavlov. Cond. intertrial magazine entries0.00.00.00.0-0.10.2-0.1-0.00.10.10.1-0.10.1-0.10.00.2
Pavlov. Cond. lever-magazine prob. diff.1.92.93.7-1.8-1.41.91.71.7-1.9-1.8-1.61.71.81.7-1.7-1.6
Pavlov. Cond. response bias1.52.12.7-1.5-1.11.61.51.4-1.7-1.5-1.41.41.71.5-1.6-1.2
Time in closed arm before self-admin0.00.00.2-0.2-0.40.10.00.10.2-0.0-0.2-0.1-0.2-0.10.1-0.3
Time in closed arm after self-admin0.70.81.70.80.6-1.0-0.4-0.70.90.90.7-0.9-1.1-1.00.81.3
Time in open arm before self-admin1.01.32.61.31.1-1.4-0.7-0.91.01.11.1-1.1-1.0-1.00.91.6
Time in open arm after self-admin0.40.51.0-0.4-0.20.50.40.3-1.0-0.8-0.40.80.90.9-0.7-1.0
Bone: periosteal estimation3.99.311.73.33.4-3.1-3.2-3.23.13.13.2-2.9-2.8-2.82.72.6
Bone: periosteal perimeter3.36.68.32.92.9-2.7-2.7-2.72.72.62.6-2.4-2.4-2.42.22.2
Bone: post-yield work1.52.63.61.71.4-1.7-1.7-1.61.91.71.6-1.6-1.6-1.61.51.5
Progressive ratio test 1 active lever presses1.52.64.5-1.7-2.11.12.11.8-1.4-1.6-1.71.51.51.5-1.6-0.6
Progressive ratio test 1 breakpoint1.52.54.5-1.7-2.11.22.11.7-1.4-1.5-1.71.51.51.5-1.6-0.5
Progressive ratio test 1 inactive lever presses0.30.71.4-0.6-0.6-0.21.20.6-0.9-0.9-0.81.10.91.1-1.0-0.2
Progressive ratio test 2 active lever presses0.10.21.00.40.3-0.90.4-0.2-0.00.10.20.00.10.1-0.11.0
Progressive ratio test 2 breakpoint0.20.21.10.50.3-0.90.4-0.30.00.10.2-0.0-0.00.0-0.11.1
Progressive ratio test 2 inactive lever presses0.00.10.80.40.5-0.90.2-0.3-0.00.00.20.10.20.2-0.20.6
Incentive Sensitization - Responses0.51.32.41.51.5-1.5-0.8-1.30.81.01.2-0.8-0.9-0.80.91.4
Incentive Sensitization - Breakpoint0.71.62.71.61.6-1.6-0.9-1.40.91.11.3-0.9-1.0-0.91.01.5
Sum of active levers in priming session hrs 5-60.10.10.3-0.1-0.1-0.10.40.3-0.1-0.2-0.30.10.30.1-0.6-0.2
Progressive ratio0.00.00.10.1-0.4-0.20.00.20.20.0-0.0-0.0-0.00.0-0.10.3
Food seeking constrained by brief footshock0.60.81.9-0.60.10.51.40.7-1.0-0.8-0.81.01.01.1-1.20.2
Seeking ratio, punishment vs. effort0.10.30.6-0.40.40.30.80.2-0.8-0.5-0.40.60.60.6-0.6-0.2
Retroperitoneal fat weight1.04.66.1-2.5-2.02.32.12.3-2.3-2.1-2.12.12.32.1-2.0-1.7
Reaction time number correct0.20.61.20.70.1-0.2-1.0-0.71.10.80.7-0.8-0.7-0.80.90.5
Reaction time mean minus median0.10.70.8-0.8-0.60.80.80.8-0.9-0.9-0.90.90.80.9-0.8-0.8
Reaction time mean minus median AUC0.10.40.6-0.6-0.60.60.80.7-0.7-0.7-0.80.70.60.7-0.7-0.5
Reaction time num false alarms3.35.76.5-2.4-2.12.32.52.4-2.6-2.5-2.32.52.42.4-2.5-2.0
Reaction time num false alarms AUC2.96.67.6-2.6-2.22.42.72.5-2.7-2.7-2.52.72.62.7-2.7-2.2
Reaction time trials correct on left0.20.61.20.70.1-0.2-1.0-0.71.10.80.7-0.8-0.7-0.80.90.5
Reaction time trials on left0.10.40.90.60.0-0.1-0.9-0.60.90.70.6-0.7-0.6-0.70.80.4
Reaction time mean0.00.10.90.20.9-0.4-0.1-0.3-0.30.10.20.10.00.1-0.10.1
Reaction time mean AUC0.10.21.20.41.1-0.6-0.4-0.60.00.30.5-0.2-0.3-0.20.30.2
Median of all reaction times0.20.42.00.61.4-0.7-0.5-0.70.10.50.7-0.3-0.3-0.20.30.4
Reaction time omissions2.44.05.6-1.8-0.71.91.71.6-2.3-2.1-1.72.42.32.4-2.1-2.3
Reaction time false alarm rate3.75.17.0-2.3-1.61.92.62.2-2.6-2.4-2.22.42.32.4-2.5-1.7
Reaction time premature initiation rate0.30.51.2-0.70.10.60.80.5-1.1-0.7-0.51.00.90.9-0.8-0.2
Reaction time premature initiations0.00.10.2-0.20.20.40.1-0.0-0.4-0.1-0.00.40.40.3-0.20.0
Std. dev. reaction times0.10.40.8-0.6-0.20.50.60.6-0.9-0.7-0.60.70.70.8-0.8-0.7
Reaction time trials completed0.10.40.90.60.0-0.1-0.9-0.60.90.70.6-0.7-0.6-0.70.80.4
Reaction time trials AUC0.20.61.30.80.2-0.3-1.1-0.81.10.90.8-0.8-0.7-0.91.00.5
Run reversals in cocaine runway, females0.10.10.40.10.7-0.1-0.4-0.20.10.10.1-0.10.1-0.1-0.1-0.3
Run reversals in cocaine runway, males0.20.21.5-0.1-1.2-0.00.00.20.2-0.3-0.30.0-0.2-0.00.2-0.6
Latency to leave start box in cocaine runway0.10.20.30.40.5-0.2-0.3-0.40.20.40.4-0.4-0.5-0.40.40.6
Latency to leave start box in cocaine runway, F0.10.10.3-0.3-0.40.50.50.3-0.5-0.3-0.30.10.10.1-0.1-0.1
Latency to leave start box in cocaine runway, M1.31.32.21.11.5-1.2-1.1-1.21.01.11.3-0.9-1.0-0.91.01.1
Std. dev. time between licks in bursts0.30.52.1-0.9-1.50.90.50.8-0.4-0.5-0.70.20.40.1-0.3-0.7
Total sessions with >9 infusions0.40.51.3-0.4-0.30.01.10.6-0.6-0.6-0.61.00.71.0-0.80.2
Short access day 1 total inactive lever presses0.10.10.3-0.1-0.1-0.50.50.1-0.2-0.3-0.20.50.30.5-0.30.2
Short access day 10 total inactive lever presses0.00.21.80.41.3-0.7-0.2-0.50.10.30.40.1-0.10.10.00.4
Short access day 1 total infusions0.10.10.3-0.10.5-0.30.40.0-0.3-0.2-0.10.50.50.5-0.50.4
Short access day 10 total infusions0.60.92.3-0.9-0.90.11.50.9-1.0-1.0-1.01.20.91.2-1.0-0.0
Short access total infusions0.10.20.7-0.4-0.3-0.20.90.3-0.4-0.3-0.30.50.40.5-0.40.5
Short access day 1 locomotion0.00.00.20.10.2-0.40.1-0.30.20.10.10.20.10.2-0.10.3
Short access day 10 total locomotion0.00.10.2-0.10.40.00.30.1-0.3-0.2-0.10.40.20.4-0.30.1
Short access total locomotion0.20.30.7-0.4-0.40.10.80.4-0.4-0.5-0.50.70.50.7-0.50.0
One hour access (0.3 mA shock)1.92.33.81.71.4-1.9-1.2-1.51.41.51.5-1.5-1.4-1.41.31.8
Compulsive drug intake1.01.43.01.31.7-1.2-0.7-1.31.01.11.2-1.1-1.0-1.00.91.5
One hour access (shock baseline)0.30.81.80.90.4-1.4-0.7-0.90.80.80.8-0.8-0.8-0.80.81.0
Social response proportion1.51.92.7-1.2-0.71.51.21.2-1.3-1.4-1.31.61.61.6-1.5-1.5
Social responses1.92.53.9-1.5-1.51.71.41.6-1.5-1.6-1.61.61.61.6-1.5-2.0
Social time0.81.33.3-1.0-0.71.30.60.9-1.2-1.2-0.91.21.31.2-1.1-1.8
Soleus weight0.61.72.51.21.1-1.1-1.6-1.31.31.41.3-1.5-1.3-1.51.50.8
Bone: stiffness4.37.88.93.02.8-3.0-2.9-2.92.92.82.8-2.7-2.8-2.72.72.3
Tibialis anterior weight4.716.220.54.23.4-4.5-3.6-3.84.04.03.7-4.0-4.5-4.14.34.0
Time to tail flick, vehicle, before self-admin0.00.00.10.10.1-0.40.10.20.0-0.1-0.20.20.10.2-0.2-0.0
Time to tail flick, vehicle, after self-admin0.40.81.60.80.7-0.6-1.3-1.01.00.90.9-1.0-0.8-0.90.90.2
Time to tail flick, test, before self-admin1.51.72.3-1.3-1.30.91.21.5-1.3-1.4-1.41.41.21.4-1.3-1.4
Time to tail flick, test, after self-admin1.01.11.71.11.3-1.0-1.3-1.30.90.91.2-1.0-1.0-0.90.90.4
Delta time to tail flick, vehicle, before/after SA0.70.81.40.80.7-0.3-1.2-1.01.01.01.0-1.0-0.8-1.01.00.5
Delta time to tail flick, test, before/after SA1.41.73.21.31.8-0.8-1.4-1.71.11.31.5-1.3-1.1-1.21.00.9
Tibia length0.72.04.21.32.0-1.5-1.5-1.51.11.41.5-1.3-1.2-1.31.11.3
Ambulatory time before self-admin0.00.00.1-0.0-0.1-0.4-0.00.10.10.0-0.0-0.1-0.0-0.1-0.10.1
Ambulatory time after self-admin0.20.31.70.41.3-0.9-0.2-0.8-0.00.40.6-0.00.20.0-0.00.8
Bone: tissue strength1.92.02.51.50.9-1.4-1.3-1.31.51.51.4-1.5-1.5-1.51.51.6
Total heroin consumption2.73.14.72.02.2-1.6-1.7-2.01.61.81.8-1.8-1.5-1.71.51.7
Bone: trabecular number0.30.61.20.81.1-0.8-1.1-0.90.80.80.9-0.6-0.5-0.60.60.3
Bone: trabecular spacing0.10.10.80.00.2-0.30.60.1-0.30.0-0.10.0-0.10.0-0.00.9
Bone: trabecular thickness0.00.10.2-0.2-0.10.20.10.20.0-0.2-0.20.30.30.3-0.3-0.4
Bone: trabecular tissue density0.30.61.2-0.5-0.60.31.10.9-0.5-0.7-0.90.80.70.9-1.0-0.4
Water consumed over 24 hours0.20.40.80.30.1-0.4-0.6-0.50.60.70.6-0.8-0.7-0.80.90.6
Number of responses in last shaping day2.53.25.7-1.8-1.71.41.41.7-1.4-1.8-1.81.91.81.9-1.7-2.4