Hub : Genes

Spryd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Spryd3 0.28 0.11 0.0e+00 0.17 0.16 0.17 0.17 3.7e-18 1.5e-17 3.2e-18 4.8e-18
2 IL mRNA stability Spryd3 0.38 0.17 4.4e-04 0.19 0.08 0.12 0.15 2.1e-05 4.9e-03 8.3e-04 1.6e-04
3 Eye gene expression Spryd3 0.42 0.19 7.4e-04 0.16 0.13 0.24 0.26 1.9e-03 4.8e-03 1.2e-04 7.6e-05
4 PL mRNA stability Spryd3 0.11 0.08 2.1e-05 0.04 0.05 0.05 0.05 2.3e-05 6.1e-06 8.5e-06 7.3e-06
5 BLA gene expression Spryd3 0.11 0.03 2.3e-06 0.11 0.08 0.06 0.12 3.0e-06 4.8e-05 4.5e-04 1.1e-06
6 NAcc mRNA stability Spryd3 0.08 0.05 6.6e-06 0.04 0.03 0.03 0.04 2.9e-07 1.8e-05 9.4e-06 3.3e-07
7 NAcc gene expression Spryd3 0.2 0.01 0.0e+00 0.36 0.38 0.38 0.38 4.8e-57 6.4e-61 1.2e-61 2.5e-61
8 BLA mRNA stability Spryd3 0.06 0.05 2.8e-03 0.05 0.02 0 0.03 1.0e-03 1.9e-02 3.0e-01 6.4e-03
9 PL gene expression Spryd3 0.11 0.02 1.6e-14 0.14 0.14 0.14 0.14 2.4e-15 2.5e-15 6.9e-15 2.2e-15
10 IL gene expression Spryd3 0.43 0.14 1.7e-06 0.22 0.21 0.23 0.24 6.6e-06 9.0e-06 3.5e-06 1.5e-06
11 Brain gene expression Spryd3 0.22 0.1 8.0e-11 0.13 0.12 0.13 0.14 2.7e-12 1.6e-11 2.8e-12 1.5e-12
12 Brain mRNA stability Spryd3 0.23 0.09 5.3e-15 0.18 0.17 0.18 0.18 5.9e-17 7.6e-16 1.7e-16 1.0e-16
13 Liver gene expression Spryd3 0.1 0.05 5.2e-09 0.08 0.08 0.08 0.07 6.1e-09 3.6e-09 5.1e-09 9.9e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.93.34.5-2.0-2.1-1.9-2.1-2.0-1.8-1.8-1.9-1.7-1.6-1.6-1.61.3
Area under the delay curve0.40.51.1-0.8-0.9-1.1-0.7-0.7-0.7-0.7-0.7-0.5-0.5-0.5-0.50.6
BMI with tail2.37.912.0-3.1-3.5-2.6-3.0-3.0-2.6-2.8-3.0-2.5-2.7-2.5-2.62.4
BMI without tail1.03.24.1-2.0-1.7-1.4-1.9-1.8-2.0-1.9-1.8-1.8-1.8-1.8-1.81.6
Body weight0.83.75.0-2.1-2.1-1.7-2.2-2.0-1.9-1.9-2.0-1.9-1.9-1.9-1.91.3
Weight adjusted by age0.61.02.60.91.10.70.80.91.01.11.00.90.80.90.9-1.6
Bone surface3.76.78.1-2.9-2.8-2.7-2.8-2.7-2.7-2.7-2.7-2.5-2.4-2.4-2.32.2
Bone volume3.46.17.2-2.6-2.7-2.6-2.6-2.6-2.6-2.6-2.5-2.3-2.3-2.3-2.32.2
Breakpoint value in progressive ratio session1.82.23.3-1.6-1.8-1.4-1.3-1.7-1.5-1.5-1.5-1.4-1.3-1.4-1.11.6
Number of licking bursts0.10.10.70.20.80.10.40.4-0.10.10.3-0.1-0.1-0.10.00.2
Context. condit. distance diff. score0.30.31.1-0.5-0.7-0.6-0.3-0.6-0.4-0.6-0.6-0.6-0.4-0.5-0.31.0
Locomotion velocity, session 15.76.110.22.93.22.92.32.62.32.42.52.22.22.12.0-2.3
Locomotion distance, session 14.15.29.12.53.02.52.22.51.92.22.42.12.02.01.9-2.1
Locomotion velocity, session 21.92.24.31.62.11.90.91.51.21.41.41.21.31.11.1-2.0
Locomotion distance, session 24.15.77.32.42.72.52.42.52.22.42.52.32.32.32.2-2.2
Locomotion velocity, session 32.02.33.81.81.91.91.21.51.31.41.51.51.41.41.0-1.6
Locomotion distance, session 31.31.42.51.41.61.60.91.21.11.11.11.11.11.10.8-1.2
Stereotopy head waving bouts, day 31.41.62.4-1.3-1.3-1.6-1.0-1.2-1.3-1.3-1.2-1.2-1.3-1.2-1.21.4
Stereotopy head waving duration, day 30.40.50.6-0.7-0.6-0.7-0.7-0.6-0.8-0.7-0.7-0.7-0.7-0.7-0.70.7
Locomotion velocity, session 70.80.91.51.11.00.91.21.01.00.91.00.90.90.90.9-0.2
Locomotion distance, session 72.63.35.92.02.42.01.72.01.51.71.91.51.71.51.8-1.7
Stereotopy head waving bouts, day 71.21.42.5-1.2-1.3-1.6-0.7-1.1-1.0-1.1-1.1-1.0-1.3-1.0-1.21.5
Stereotopy head waving duration, day 71.61.92.8-1.4-1.5-1.7-1.1-1.4-1.2-1.3-1.3-1.2-1.4-1.2-1.51.6
Locomotion velocity, session 80.00.00.20.20.20.10.30.10.40.20.10.10.10.10.10.3
Locomotion distance, session 82.13.14.31.92.11.91.81.81.61.71.81.61.81.61.7-1.4
Degree of sensitization distance0.10.10.30.20.30.00.40.40.10.20.40.10.30.20.6-0.1
Degree of sensitization stereotypy0.91.01.7-0.9-1.1-1.3-0.7-0.9-0.8-0.9-0.9-0.9-1.1-0.9-1.11.3
Conditioned locomotion0.80.91.10.90.81.10.90.90.90.90.91.01.01.01.0-0.7
Cocaine response after cond. corrected1.61.92.31.41.51.31.41.51.31.41.51.41.21.41.3-1.4
Cocaine response after cond. not corrected1.61.92.41.41.21.31.41.41.51.41.41.41.31.41.2-1.4
Cocaine response before conditioning0.00.00.20.2-0.30.20.2-0.00.50.2-0.10.20.20.20.10.1
Saline control response0.30.30.70.50.10.50.80.50.80.60.50.60.70.60.80.0
Bone: connectivity density0.20.41.0-0.6-1.0-0.7-0.7-0.8-0.3-0.5-0.7-0.5-0.4-0.4-0.40.3
Bone: cortical apparent density1.72.33.21.41.61.11.81.71.41.61.71.51.41.51.8-1.2
Bone: cortical area1.42.23.6-1.7-1.9-1.6-1.6-1.6-1.5-1.5-1.5-1.4-1.3-1.3-1.11.1
Bone: cortical porosity0.10.10.30.30.20.60.10.20.40.30.20.30.50.30.4-0.4
Bone: cortical porosity0.20.20.40.40.20.70.30.30.50.40.30.50.60.50.5-0.5
Bone: cortical thickness0.10.10.2-0.4-0.5-0.4-0.4-0.3-0.3-0.3-0.3-0.4-0.2-0.30.1-0.0
Bone: cortical thickness2.22.64.81.41.21.71.31.51.61.71.61.61.81.71.8-2.2
Bone: cortical tissue density1.92.53.31.51.71.21.81.81.51.61.81.51.51.61.8-1.3
Condit. Reinf. active minus inactive responses0.80.91.11.00.81.00.90.91.00.90.90.91.00.91.0-0.7
Condit. Reinf. active-inactive response ratio0.50.50.70.70.50.80.60.60.80.70.60.70.80.70.8-0.7
Condit. Reinf. active responses2.02.52.91.61.51.71.51.51.51.51.61.61.71.61.7-1.4
Condit. Reinf. inactive responses2.42.93.31.71.71.81.71.81.51.71.81.81.71.81.7-1.5
Incentive salience index mean0.40.40.60.60.50.70.70.60.70.70.60.70.70.70.8-0.5
Condit. Reinf. lever presses0.00.00.1-0.10.2-0.10.30.10.00.10.20.10.00.10.10.1
Condit. Reinf. active minus inactive responses0.20.30.5-0.6-0.6-0.7-0.3-0.5-0.4-0.5-0.5-0.5-0.5-0.5-0.40.7
Condit. Reinf. active-inactive response ratio0.20.20.3-0.6-0.6-0.5-0.4-0.5-0.3-0.5-0.4-0.5-0.4-0.4-0.40.5
Condit. Reinf. active responses0.20.30.9-0.5-0.5-0.8-0.1-0.4-0.4-0.5-0.4-0.5-0.5-0.5-0.41.0
Condit. Reinf. inactive responses0.10.20.40.50.50.20.70.50.30.40.40.40.20.30.40.1
Condit. Reinf. lever presses0.40.50.80.70.30.70.90.60.70.60.60.70.90.80.9-0.2
Condit. Reinf. lever reinforcers received0.00.00.30.0-0.1-0.20.40.10.10.00.00.0-0.00.00.10.5
Conditioned reinforcement - actives0.20.41.40.41.2-0.40.90.50.50.60.50.60.60.60.60.2
Conditioned reinforcement - inactives1.72.53.81.31.20.61.71.41.81.71.51.81.91.92.0-1.2
Conditioned locomotion0.10.10.8-0.40.5-0.90.2-0.1-0.20.1-0.00.00.20.10.20.5
Patch foraging indifference point 0 sec1.12.13.81.72.01.51.71.61.61.51.51.11.11.11.2-0.9
Patch foraging indifference point AUC1.11.62.41.51.61.21.51.51.11.21.41.21.11.21.0-0.8
Delay disc. indifference point, 0s delay0.00.00.1-0.00.2-0.2-0.10.1-0.00.10.1-0.0-0.1-0.0-0.0-0.3
Delay disc. indifference point, 16s delay0.20.20.8-0.4-0.9-0.6-0.5-0.4-0.3-0.4-0.4-0.1-0.1-0.1-0.10.4
Delay disc. indifference point, 2s delay2.22.54.6-1.7-1.3-2.2-1.2-1.4-1.6-1.5-1.4-1.5-1.7-1.5-1.61.8
Delay disc. indifference point, 24s delay0.20.20.4-0.6-0.4-0.6-0.4-0.6-0.5-0.5-0.5-0.3-0.3-0.3-0.50.5
Delay disc. indifference point, 4s delay0.70.81.3-1.0-1.1-1.1-0.8-0.8-0.9-0.9-0.8-0.8-0.7-0.7-0.60.9
Delay disc. indifference point, 8s delay0.10.20.4-0.5-0.6-0.5-0.6-0.3-0.4-0.4-0.4-0.3-0.2-0.3-0.30.3
Indifference point function ln k2.54.35.6-2.3-2.2-2.0-2.4-2.3-2.0-2.1-2.2-2.2-1.9-2.1-1.91.4
Indifference point function log k2.54.35.6-2.3-2.2-2.0-2.4-2.3-2.0-2.1-2.2-2.2-1.9-2.1-1.91.4
Patch foraging total patch changes 0 sec1.42.54.61.92.11.71.81.81.71.61.71.31.31.21.2-1.2
Patch foraging total patch changes 12 sec3.74.86.92.42.42.12.62.42.32.22.32.11.92.02.0-1.3
Patch foraging total patch changes 18 sec3.35.17.62.62.82.32.62.52.32.32.42.11.92.01.9-1.4
Patch foraging total patch changes 24 sec0.61.12.21.31.50.91.51.31.01.01.10.80.60.70.6-0.2
Patch foraging total patch changes 6 sec1.72.57.82.02.81.61.91.91.31.51.81.10.81.00.8-1.0
Patch foraging time to switch 0 sec0.10.10.20.30.40.10.50.40.30.40.40.30.20.30.3-0.4
Patch foraging water rate 0 sec0.10.20.3-0.4-0.5-0.4-0.5-0.5-0.3-0.5-0.5-0.5-0.3-0.5-0.40.6
Patch foraging water rate 12 sec0.00.10.2-0.3-0.40.0-0.5-0.4-0.1-0.3-0.5-0.4-0.2-0.4-0.30.2
Patch foraging water rate 18 sec0.00.00.10.1-0.00.00.20.00.30.10.0-0.00.0-0.00.00.2
Patch foraging water rate 24 sec0.50.71.3-0.9-0.8-0.9-0.7-0.8-0.8-0.9-0.9-0.9-0.8-0.9-0.71.1
Patch foraging water rate 6 sec1.11.63.9-1.2-2.0-1.2-1.3-1.5-0.8-1.2-1.5-1.0-0.9-1.0-1.21.2
Seeking ratio, delayed vs. immediate footshock0.20.20.70.10.10.10.40.40.20.50.40.70.70.70.9-0.5
Distance traveled before self-admin0.10.10.4-0.2-0.2-0.7-0.3-0.1-0.2-0.2-0.2-0.3-0.2-0.3-0.10.2
Distance traveled after self-admin0.10.20.6-0.2-0.8-0.70.1-0.40.3-0.1-0.30.20.40.20.30.6
Extensor digitorum longus weight6.726.231.2-5.4-4.4-5.6-5.0-5.0-5.3-5.1-4.9-5.3-5.4-5.3-5.24.5
Bone: elastic displacement1.31.52.31.21.51.51.11.31.01.11.21.11.31.11.2-1.0
Bone: elastic work0.30.51.30.51.01.00.20.60.30.50.60.40.70.50.6-1.1
Bone: endosteal estimation3.88.39.3-3.1-3.0-2.8-3.0-3.0-2.9-3.0-3.0-2.7-2.7-2.7-2.82.5
Bone: endosteal perimeter3.47.39.0-3.0-3.0-2.7-2.9-2.9-2.8-2.8-2.8-2.5-2.5-2.5-2.52.2
Epididymis fat weight0.20.71.60.80.01.00.10.31.10.80.40.91.11.00.7-1.3
Delta time in closed arm before/after self-admin0.60.61.3-0.7-1.2-0.6-0.6-0.9-0.4-0.7-0.9-0.7-0.7-0.6-0.61.1
Delta time in open arm before/after self-admin2.72.64.41.61.41.41.21.51.81.71.51.81.81.71.5-2.1
Diff in mean of infusions in LGA sessions0.10.10.3-0.5-0.1-0.1-0.5-0.6-0.3-0.2-0.3-0.3-0.3-0.3-0.1-0.1
Delay discount exponential model param0.80.91.71.01.11.31.00.90.90.90.90.70.70.70.8-0.8
Extinction: sum of active levers before priming4.65.17.0-2.2-1.8-1.3-2.5-2.3-2.6-2.4-2.2-2.6-2.5-2.5-2.31.7
Active lever presses in extinction session 60.60.61.0-0.9-1.0-0.5-0.8-0.5-0.9-0.9-0.7-0.9-0.6-0.8-0.50.9
Bone: final force3.75.97.8-2.5-2.5-2.4-2.8-2.6-2.4-2.4-2.5-2.5-2.3-2.5-2.31.7
Bone: final moment4.87.79.9-2.9-2.7-2.7-3.1-2.9-2.8-2.8-2.9-2.9-2.6-2.8-2.62.0
Food consumed during 24 hour testing period0.10.10.4-0.3-0.7-0.2-0.4-0.5-0.1-0.3-0.4-0.2-0.2-0.1-0.30.3
Glucose0.40.71.50.61.20.70.71.00.60.81.00.70.80.70.9-0.8
Heart weight0.20.31.7-0.5-1.3-0.3-0.5-0.8-0.1-0.3-0.60.00.10.10.00.1
Delay discount hyperbolic model param0.91.02.01.11.11.41.00.91.01.00.90.80.80.80.9-0.9
Intermittent access intake day 1-15 change0.00.10.2-0.2-0.2-0.1-0.2-0.4-0.2-0.3-0.3-0.2-0.1-0.2-0.20.4
Intermittent access intake escalation0.00.10.2-0.2-0.2-0.1-0.3-0.4-0.3-0.3-0.3-0.2-0.2-0.2-0.30.2
Intermittent access intake escalation 20.00.00.00.0-0.20.1-0.1-0.10.10.0-0.1-0.00.00.00.0-0.0
Intermitt. access day 1 inactive lever presses0.00.20.7-0.2-0.8-0.80.1-0.5-0.1-0.2-0.30.0-0.20.0-0.10.5
Intermitt. access day 15 inactive lever presses0.00.10.1-0.1-0.3-0.3-0.0-0.30.20.1-0.10.30.30.30.2-0.2
Intermitt. access escalation Index0.60.81.6-0.7-0.1-1.2-0.4-0.6-1.1-0.9-0.6-1.0-1.2-1.1-1.01.3
Intermittent access day 1 total infusions0.71.22.30.91.00.21.51.01.31.11.11.31.11.31.2-0.3
Intermittent access day 15 total infusions0.60.92.20.91.50.31.30.91.01.01.00.90.80.90.9-0.3
Intermittent access terminal intake (last 3 days)0.60.82.00.71.1-0.11.40.81.00.90.90.90.80.90.90.1
Intermittent access total infusions0.60.71.80.61.0-0.21.30.80.90.80.80.80.70.80.80.2
Intermittent access day 1 locomotion0.20.20.70.30.6-0.10.90.30.40.40.40.40.40.50.40.4
Intermittent access day 15 total locomotion0.00.10.2-0.4-0.5-0.3-0.3-0.3-0.2-0.3-0.4-0.10.1-0.0-0.00.4
Intermittent access total locomotion0.00.10.20.00.1-0.40.4-0.00.20.10.00.20.20.20.10.5
Intermittent access standard deviation0.71.42.01.00.80.71.21.21.11.21.21.21.41.31.4-1.1
Left kidney weight0.00.10.3-0.3-0.3-0.0-0.5-0.3-0.1-0.0-0.10.00.20.10.2-0.5
Right kidney weight0.31.22.7-1.1-1.1-0.7-1.6-1.3-1.2-1.0-1.1-1.1-0.9-1.1-0.90.1
Cocaine induced anxiety1.62.23.0-1.4-1.0-1.4-1.6-1.2-1.7-1.6-1.4-1.7-1.5-1.6-1.61.4
Post-drug Anxiety2.12.33.1-1.3-1.8-1.1-1.6-1.4-1.5-1.6-1.6-1.6-1.4-1.5-1.51.6
Baseline Anxiety0.50.61.10.6-0.31.00.50.41.10.70.60.90.90.90.9-0.9
Tail length0.31.12.11.11.51.11.01.20.71.01.21.01.11.01.0-0.8
Length with tail0.00.10.30.30.40.30.10.30.30.30.40.20.30.20.2-0.6
Length without tail0.31.01.7-1.1-1.3-1.2-1.2-1.1-0.7-0.9-1.1-0.9-0.8-0.9-0.90.5
Times rat made contact with spout0.50.60.9-0.5-0.8-0.5-0.9-0.9-0.4-0.7-0.9-0.8-0.7-0.8-0.90.6
Lifetime Intake0.40.51.50.60.7-0.31.20.60.70.60.60.70.60.70.70.4
Liver weight, left6.110.012.6-3.4-3.5-3.0-3.5-3.5-3.1-3.2-3.4-2.9-2.9-2.9-3.02.7
Liver weight, right0.40.71.4-1.0-1.2-1.0-1.2-1.1-0.6-0.7-1.0-0.8-0.6-0.7-0.60.1
Locomotor activity0.00.00.10.20.40.30.10.2-0.00.00.1-0.2-0.1-0.20.0-0.1
Locomotor testing distance0.10.10.60.40.80.50.30.40.10.10.3-0.10.1-0.20.1-0.0
Locomotor testing rearing0.00.10.20.10.40.2-0.30.1-0.3-0.20.1-0.4-0.2-0.4-0.2-0.2
Locomotion in novel chamber5.46.87.8-2.6-2.4-2.5-2.7-2.5-2.7-2.7-2.6-2.7-2.8-2.7-2.82.3
Locomotion in novel chamber post-restriction0.10.20.8-0.4-0.2-0.50.1-0.3-0.5-0.4-0.2-0.3-0.5-0.3-0.40.9
Fecal boli incidents, locomotor time 11.82.63.21.51.51.61.61.51.81.71.51.71.81.71.5-1.6
Change in fecal boli incidents, locomotor task0.80.81.5-0.7-0.4-0.7-0.9-0.7-1.2-0.9-0.8-1.0-1.0-1.0-0.80.8
Time >=10cm from walls, locomotor time 10.30.30.60.50.10.60.60.50.70.60.50.60.60.60.5-0.4
Bouts of movement, locomotor time 11.61.92.51.31.41.31.31.51.11.41.41.41.41.41.6-1.2
Total resting periods, locomotor time 12.52.83.61.71.91.81.51.71.41.71.61.61.71.71.8-1.6
Rest time, locomotor task time 10.50.62.40.81.50.80.60.90.20.60.80.50.60.50.5-0.6
Distance moved, locomotor task time 10.20.30.8-0.4-0.8-0.6-0.2-0.5-0.4-0.6-0.5-0.4-0.6-0.4-0.50.9
Vertical activity count, locomotor time 10.10.31.4-0.8-0.9-1.2-0.2-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.20.6
Time >=10cm from walls, locomotor time 20.10.10.20.10.20.20.30.40.30.30.40.10.30.20.4-0.1
Bouts of movement, locomotor time 20.81.31.6-1.2-1.2-1.2-1.0-0.9-1.2-1.2-1.0-1.3-1.2-1.2-1.01.3
Total resting periods, locomotor time 20.61.11.5-1.1-1.2-1.2-0.8-0.8-1.1-1.1-0.9-1.1-1.1-1.1-0.81.2
Rest time, locomotor task time 20.70.81.71.01.30.91.01.10.70.90.90.90.80.80.7-0.6
Distance moved, locomotor task time 20.00.00.10.0-0.3-0.1-0.3-0.1-0.1-0.1-0.0-0.2-0.1-0.2-0.0-0.1
Vertical activity count, locomotor time 20.30.40.9-0.6-0.4-0.9-0.6-0.4-0.7-0.6-0.4-0.7-0.6-0.7-0.50.2
Light reinforcement 11.33.14.21.81.91.62.01.91.71.81.91.61.61.61.8-1.3
Light reinforcement 22.23.44.22.02.01.91.92.01.81.92.01.61.61.51.7-1.9
Bone: marrow area3.78.09.0-3.0-3.0-2.8-3.0-3.0-2.9-2.9-2.9-2.6-2.7-2.7-2.82.5
Bone: maximum diameter1.22.23.2-1.7-1.8-1.7-1.4-1.5-1.5-1.5-1.5-1.3-1.3-1.3-1.21.5
Bone: maximum force3.05.46.8-2.5-2.0-2.3-2.5-2.3-2.6-2.4-2.3-2.3-2.3-2.3-2.21.8
Bone: maximum moment4.06.98.8-2.8-2.3-2.5-2.9-2.6-3.0-2.7-2.6-2.7-2.6-2.7-2.52.1
Mean time between licks in bursts0.20.42.10.91.50.70.50.70.30.40.60.10.1-0.0-0.0-0.3
Mean num. licks in bursts0.20.31.4-0.5-1.2-0.3-0.9-0.8-0.1-0.4-0.8-0.2-0.2-0.2-0.50.0
Cd content in liver0.10.20.30.30.50.50.50.30.30.30.40.40.50.50.5-0.0
Co content in liver0.60.71.7-0.9-0.3-0.7-0.8-0.7-1.3-0.9-0.7-0.9-0.8-0.9-0.60.8
Cu content in liver7.99.412.5-3.1-3.5-3.3-2.8-3.2-2.8-3.1-3.2-2.9-2.9-2.9-2.83.2
Fe content in liver0.20.20.5-0.40.1-0.4-0.4-0.2-0.6-0.5-0.3-0.7-0.5-0.7-0.50.6
K content in liver1.41.32.3-1.0-0.7-1.0-1.3-0.9-1.5-1.2-1.0-1.3-1.1-1.3-1.10.9
Mg content in liver1.21.21.9-0.9-0.7-1.0-1.1-0.9-1.4-1.2-1.0-1.3-1.0-1.3-1.01.1
Mn content in liver0.10.10.50.40.70.40.00.30.00.10.3-0.3-0.1-0.30.0-0.2
Na content in liver2.02.12.9-1.4-1.3-1.4-1.5-1.2-1.5-1.5-1.4-1.7-1.4-1.7-1.31.4
Rb content in liver1.72.03.9-1.6-1.3-1.5-1.1-1.3-1.7-1.5-1.3-1.2-1.2-1.2-1.12.0
Se content in liver0.30.40.50.60.70.70.60.70.50.60.60.40.70.40.7-0.6
Sr content in liver0.10.10.10.10.10.2-0.4-0.1-0.1-0.1-0.2-0.3-0.2-0.3-0.2-0.4
Zn content in liver0.60.61.00.80.30.70.80.60.90.80.61.01.01.01.0-0.6
Bone: minimum diameter2.64.86.8-2.4-2.6-2.2-2.3-2.4-2.1-2.2-2.3-2.1-2.0-2.0-1.81.9
Time in familiar zone, hab. session 10.10.10.50.20.10.4-0.00.20.10.20.20.20.30.20.3-0.7
Time in novel zone, hab. session 10.20.20.9-0.4-0.3-0.70.0-0.3-0.2-0.3-0.3-0.3-0.4-0.3-0.21.0
Total zone transitions, hab. session 11.21.62.51.31.31.01.61.41.31.31.41.31.11.31.2-0.9
Total locomotion distance, hab. session 12.73.84.42.11.82.01.91.92.02.01.92.02.02.02.0-1.8
Locomotion velocity, hab. session 11.82.63.21.81.71.81.51.61.51.61.61.61.51.61.5-1.7
Time in familiar zone, hab. session 22.02.12.9-1.4-1.1-1.3-1.7-1.5-1.5-1.5-1.5-1.5-1.4-1.5-1.51.0
Time in novel zone, hab. session 20.40.40.80.60.60.40.90.70.60.60.70.60.50.60.7-0.1
Total zone transitions, hab. session 21.52.02.21.31.51.41.41.41.41.41.41.51.31.51.3-1.4
Total locomotion distance, hab. session 22.43.14.11.71.51.91.51.61.81.81.71.91.81.81.6-2.0
Locomotion velocity, hab. session 22.23.04.51.71.51.91.41.61.81.81.61.91.71.81.6-2.1
Novel to familiar place preference ratio0.00.00.3-0.1-0.5-0.2-0.1-0.20.1-0.1-0.2-0.1-0.2-0.0-0.20.1
Novelty place preference0.00.00.1-0.2-0.4-0.3-0.2-0.3-0.0-0.2-0.2-0.1-0.2-0.1-0.20.2
Time in novel zone, NPP test0.10.10.3-0.3-0.5-0.4-0.3-0.4-0.2-0.3-0.4-0.3-0.4-0.3-0.40.4
Total zone transitions, NPP test5.47.88.83.03.02.82.92.92.72.82.92.82.62.72.5-2.6
Total locomotion distance, NPP test7.19.711.53.33.03.42.93.13.03.23.13.23.13.12.9-3.4
Locomotion velocity, NPP test7.110.012.43.33.03.52.83.13.03.23.13.23.13.22.9-3.5
Intraocular pressure0.30.41.00.60.70.51.00.80.60.40.70.40.60.40.60.5
Delta distance traveled before/after self-admin0.50.51.30.5-0.50.90.50.11.00.60.30.91.10.90.8-0.4
Delta ambulatory time before/after self-admin0.30.41.00.3-0.90.50.4-0.20.90.40.10.81.00.80.7-0.1
Parametrial fat weight0.30.61.01.00.70.90.90.90.70.60.70.81.00.80.9-0.0
Pavlov. Cond. lever latency0.60.71.60.90.51.20.40.60.90.80.60.91.00.80.8-1.3
Pavlov. Cond. magazine entry latency1.21.62.5-1.3-0.8-1.6-0.9-1.0-1.3-1.2-1.1-1.3-1.5-1.3-1.41.5
Pavlov. Cond. change in total contacts2.22.33.6-1.6-1.4-1.9-1.1-1.4-1.4-1.5-1.4-1.4-1.7-1.4-1.61.8
Pavlov. Cond. index score2.32.94.7-1.9-1.3-2.2-1.3-1.5-1.7-1.7-1.5-1.7-1.9-1.7-1.72.0
Pavlov. Cond. latency score2.43.04.9-1.9-1.4-2.2-1.2-1.5-1.7-1.7-1.5-1.7-1.9-1.7-1.72.1
Pavlov. Cond. lever contacts0.81.01.7-1.0-0.6-1.3-0.6-0.8-1.0-1.0-0.8-1.0-1.2-1.0-1.11.3
Pavlov. Cond. magazine entry number0.70.91.71.10.61.30.60.81.00.90.80.91.20.91.1-1.2
Pavlov. Cond. intertrial magazine entries3.13.74.72.21.72.21.91.91.91.91.81.92.01.91.9-1.6
Pavlov. Cond. lever-magazine prob. diff.2.32.84.6-1.8-1.2-2.1-1.2-1.4-1.7-1.6-1.5-1.7-1.9-1.6-1.72.0
Pavlov. Cond. response bias0.60.71.2-0.9-0.4-1.1-0.5-0.6-0.9-0.8-0.7-0.8-1.0-0.8-1.01.0
Pavlov. Cond. lever latency1.72.32.9-1.5-1.1-1.6-1.6-1.5-1.7-1.5-1.4-1.5-1.7-1.5-1.71.1
Pavlov. Cond. magazine entry latency3.54.25.52.11.92.31.82.02.12.12.02.02.12.02.0-2.3
Pavlov. Cond. change in total contacts0.00.10.20.1-0.3-0.10.50.10.50.20.10.20.10.20.30.2
Pavlov. Cond. index score2.83.84.52.01.62.11.91.92.12.01.91.92.11.92.0-1.8
Pavlov. Cond. latency score2.93.94.62.01.72.11.91.92.12.01.91.92.01.92.0-1.9
Pavlov. Cond. lever contacts2.23.14.01.81.31.91.81.71.91.81.71.72.01.81.9-1.4
Pavlov. Cond. magazine entry number1.62.02.7-1.4-1.1-1.5-1.3-1.3-1.6-1.5-1.3-1.4-1.5-1.4-1.51.4
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.00.10.2-0.1-0.0-0.1-0.1-0.1-0.10.1-0.1-0.00.2
Pavlov. Cond. lever-magazine prob. diff.2.22.93.71.81.41.91.71.71.91.81.61.71.81.71.7-1.6
Pavlov. Cond. response bias1.62.12.71.51.11.61.51.41.71.51.41.41.71.51.6-1.2
Time in closed arm before self-admin0.00.00.20.20.40.10.00.1-0.20.00.2-0.1-0.2-0.1-0.1-0.3
Time in closed arm after self-admin0.70.81.7-0.8-0.6-1.0-0.4-0.7-0.9-0.9-0.7-0.9-1.1-1.0-0.81.3
Time in open arm before self-admin1.21.32.6-1.3-1.1-1.4-0.7-0.9-1.0-1.1-1.1-1.1-1.0-1.0-0.91.6
Time in open arm after self-admin0.40.51.00.40.20.50.40.31.00.80.40.80.90.90.7-1.0
Bone: periosteal estimation4.49.311.7-3.3-3.4-3.1-3.2-3.2-3.1-3.1-3.2-2.9-2.8-2.8-2.72.6
Bone: periosteal perimeter3.86.68.3-2.9-2.9-2.7-2.7-2.7-2.7-2.6-2.6-2.4-2.4-2.4-2.22.2
Bone: post-yield work1.82.63.6-1.7-1.4-1.7-1.7-1.6-1.9-1.7-1.6-1.6-1.6-1.6-1.51.5
Progressive ratio test 1 active lever presses2.12.64.51.72.11.12.11.81.41.51.71.51.51.51.6-0.6
Progressive ratio test 1 breakpoint2.02.54.51.72.11.22.11.71.41.51.71.51.51.51.6-0.5
Progressive ratio test 1 inactive lever presses0.50.71.40.60.6-0.21.20.60.90.90.81.10.91.11.0-0.2
Progressive ratio test 2 active lever presses0.20.21.0-0.4-0.3-0.90.4-0.20.0-0.1-0.20.00.10.10.11.0
Progressive ratio test 2 breakpoint0.20.21.1-0.5-0.3-0.90.4-0.3-0.0-0.1-0.2-0.0-0.00.00.11.1
Progressive ratio test 2 inactive lever presses0.10.20.8-0.4-0.5-0.90.2-0.30.0-0.1-0.20.10.20.20.20.6
Incentive Sensitization - Responses0.91.32.4-1.5-1.5-1.5-0.8-1.3-0.8-1.0-1.2-0.8-0.9-0.8-0.91.4
Incentive Sensitization - Breakpoint1.21.62.7-1.6-1.6-1.6-0.9-1.4-0.9-1.1-1.3-0.9-1.0-0.9-1.01.5
Sum of active levers in priming session hrs 5-60.10.10.30.10.1-0.10.40.30.10.20.30.10.30.10.6-0.2
Progressive ratio0.00.00.1-0.10.4-0.20.00.2-0.2-0.00.0-0.0-0.00.00.10.3
Food seeking constrained by brief footshock0.60.81.90.6-0.10.51.40.71.00.80.81.01.01.11.20.2
Seeking ratio, punishment vs. effort0.20.30.60.4-0.40.30.80.20.80.50.40.60.60.60.6-0.2
Retroperitoneal fat weight1.14.66.12.52.02.32.12.32.32.12.12.12.32.12.0-1.7
Reaction time number correct0.30.61.2-0.7-0.1-0.2-1.0-0.7-1.1-0.8-0.7-0.8-0.7-0.8-0.90.5
Reaction time mean minus median0.30.70.80.80.60.80.80.80.90.90.90.90.80.90.8-0.8
Reaction time mean minus median AUC0.20.40.60.60.60.60.80.70.70.70.80.70.60.70.7-0.5
Reaction time num false alarms4.05.76.52.42.12.32.52.42.62.52.32.52.42.42.5-2.0
Reaction time num false alarms AUC4.26.67.62.62.22.42.72.52.72.72.52.72.62.72.7-2.2
Reaction time trials correct on left0.30.61.2-0.7-0.1-0.2-1.0-0.7-1.1-0.8-0.7-0.8-0.7-0.8-0.90.5
Reaction time trials on left0.20.40.9-0.6-0.0-0.1-0.9-0.6-0.9-0.7-0.6-0.7-0.6-0.7-0.80.4
Reaction time mean0.10.10.9-0.2-0.9-0.4-0.1-0.30.3-0.1-0.20.10.00.10.10.1
Reaction time mean AUC0.10.21.2-0.4-1.1-0.6-0.4-0.6-0.0-0.3-0.5-0.2-0.3-0.2-0.30.2
Median of all reaction times0.30.42.0-0.6-1.4-0.7-0.5-0.8-0.1-0.5-0.7-0.3-0.3-0.2-0.30.4
Reaction time omissions2.74.05.61.80.71.91.71.62.32.11.72.42.32.42.1-2.3
Reaction time false alarm rate3.75.17.02.31.61.82.62.22.62.42.22.42.32.42.5-1.7
Reaction time premature initiation rate0.40.51.20.7-0.10.60.80.51.10.70.51.00.90.90.8-0.2
Reaction time premature initiations0.00.10.20.2-0.20.40.1-0.00.40.10.00.40.40.30.20.0
Std. dev. reaction times0.20.40.80.60.20.50.60.60.90.70.60.70.70.80.8-0.7
Reaction time trials completed0.20.40.9-0.6-0.0-0.1-0.9-0.6-0.9-0.7-0.6-0.7-0.6-0.7-0.80.4
Reaction time trials AUC0.30.61.3-0.8-0.2-0.3-1.1-0.8-1.1-0.9-0.8-0.8-0.7-0.9-1.00.5
Run reversals in cocaine runway, females0.10.10.4-0.1-0.7-0.1-0.4-0.2-0.1-0.1-0.1-0.10.1-0.10.1-0.3
Run reversals in cocaine runway, males0.20.21.50.11.2-0.00.00.2-0.20.30.30.0-0.2-0.0-0.2-0.6
Latency to leave start box in cocaine runway0.10.20.3-0.4-0.5-0.2-0.3-0.4-0.2-0.4-0.4-0.4-0.5-0.4-0.40.6
Latency to leave start box in cocaine runway, F0.10.10.30.30.40.50.50.30.50.30.30.10.10.10.1-0.1
Latency to leave start box in cocaine runway, M1.41.32.2-1.1-1.5-1.2-1.1-1.2-1.0-1.1-1.3-0.9-1.0-0.9-1.01.1
Std. dev. time between licks in bursts0.40.52.10.91.50.90.50.80.40.50.70.20.40.10.3-0.7
Total sessions with >9 infusions0.40.51.30.40.30.01.10.60.60.60.61.00.71.00.80.2
Short access day 1 total inactive lever presses0.10.10.30.10.1-0.50.50.10.20.30.20.50.30.50.30.2
Short access day 10 total inactive lever presses0.10.31.8-0.4-1.3-0.8-0.2-0.5-0.1-0.3-0.40.1-0.10.1-0.00.4
Short access day 1 total infusions0.10.10.30.1-0.5-0.30.40.00.30.10.10.50.50.50.50.4
Short access day 10 total infusions0.70.92.30.90.90.11.50.91.01.01.01.20.91.21.0-0.0
Short access total infusions0.20.20.70.40.3-0.20.90.30.40.30.30.50.40.50.40.5
Short access day 1 locomotion0.00.00.2-0.1-0.2-0.40.1-0.3-0.2-0.1-0.10.20.10.20.10.3
Short access day 10 total locomotion0.00.10.20.1-0.40.00.30.10.30.20.10.40.20.40.30.1
Short access total locomotion0.20.30.70.40.40.10.80.40.40.50.50.70.50.70.50.0
One hour access (0.3 mA shock)2.02.33.8-1.7-1.4-1.9-1.2-1.5-1.4-1.5-1.5-1.5-1.4-1.4-1.31.8
Compulsive drug intake1.21.43.0-1.3-1.7-1.2-0.7-1.3-1.0-1.1-1.2-1.1-1.1-1.0-0.91.5
One hour access (shock baseline)0.50.81.8-0.9-0.4-1.4-0.7-0.9-0.8-0.8-0.8-0.8-0.8-0.8-0.81.0
Social response proportion1.71.92.71.20.71.51.21.21.31.41.31.61.61.61.5-1.5
Social responses2.02.53.91.51.51.71.41.61.51.61.61.61.61.61.5-2.0
Social time1.01.33.31.00.71.30.60.91.21.20.91.21.31.21.1-1.8
Soleus weight0.61.72.5-1.2-1.1-1.1-1.6-1.3-1.3-1.3-1.3-1.5-1.3-1.5-1.50.8
Bone: stiffness4.87.88.9-3.0-2.8-3.0-2.9-2.9-2.9-2.8-2.8-2.7-2.8-2.7-2.72.3
Tibialis anterior weight4.816.220.5-4.2-3.4-4.5-3.6-3.8-4.0-4.0-3.7-4.0-4.5-4.1-4.34.0
Time to tail flick, vehicle, before self-admin0.00.00.1-0.1-0.1-0.40.10.2-0.00.10.20.20.10.20.2-0.0
Time to tail flick, vehicle, after self-admin0.60.81.6-0.8-0.7-0.6-1.3-1.0-1.0-0.9-0.9-1.0-0.8-0.9-0.90.2
Time to tail flick, test, before self-admin1.71.72.31.31.30.81.21.51.31.41.41.41.21.41.3-1.4
Time to tail flick, test, after self-admin1.01.11.7-1.1-1.3-1.0-1.3-1.3-0.9-0.9-1.2-1.0-1.0-0.9-0.90.4
Delta time to tail flick, vehicle, before/after SA0.80.81.4-0.8-0.7-0.3-1.2-1.0-1.0-1.0-1.0-1.0-0.8-1.0-1.00.5
Delta time to tail flick, test, before/after SA1.71.73.2-1.3-1.8-0.8-1.4-1.7-1.1-1.3-1.5-1.3-1.1-1.2-1.00.9
Tibia length0.72.04.2-1.3-2.0-1.5-1.5-1.5-1.1-1.4-1.5-1.3-1.2-1.3-1.11.3
Ambulatory time before self-admin0.00.00.10.00.1-0.4-0.00.1-0.1-0.00.0-0.1-0.0-0.10.10.1
Ambulatory time after self-admin0.30.31.7-0.4-1.3-0.9-0.2-0.80.0-0.4-0.6-0.00.20.00.00.8
Bone: tissue strength2.02.02.5-1.5-0.9-1.4-1.3-1.3-1.5-1.5-1.4-1.5-1.5-1.5-1.51.6
Total heroin consumption2.73.14.7-2.0-2.2-1.6-1.7-2.0-1.6-1.9-1.8-1.8-1.5-1.7-1.51.7
Bone: trabecular number0.40.61.2-0.8-1.1-0.8-1.1-0.9-0.8-0.8-0.9-0.6-0.5-0.6-0.60.3
Bone: trabecular spacing0.10.10.8-0.0-0.2-0.30.60.10.3-0.00.10.0-0.10.00.00.9
Bone: trabecular thickness0.10.10.20.20.10.20.10.2-0.00.20.20.30.30.30.3-0.4
Bone: trabecular tissue density0.40.61.20.50.60.31.10.90.50.70.90.80.70.91.0-0.4
Water consumed over 24 hours0.30.40.8-0.3-0.1-0.4-0.6-0.5-0.6-0.7-0.6-0.8-0.7-0.8-0.90.6
Number of responses in last shaping day2.93.25.71.81.71.41.41.71.41.81.81.91.81.91.7-2.4