Hub : Genes

Spred3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Spred3 0.07 0.05 1.1e-04 0.06 0.06 0.06 0.06 3.5e-04 2.8e-04 3.9e-04 6.0e-04
2 PL mRNA stability Spred3 0.04 0.03 2.2e-05 0.04 0.04 0.04 0.04 4.1e-05 9.7e-06 2.7e-05 2.5e-05
3 OFC mRNA stability Spred3 0.14 0.11 2.6e-03 0.07 0.03 0.01 0.05 1.1e-02 5.5e-02 1.5e-01 2.6e-02
4 Liver gene expression Spred3 0.1 0.07 5.4e-06 0.04 0.03 0.03 0.04 5.5e-05 1.5e-04 1.1e-04 6.3e-05
5 NAcc gene expression Spred3 0.08 0.06 6.5e-06 0.05 0.04 0.03 0.04 3.6e-06 1.1e-05 9.4e-05 9.9e-06
6 Brain gene expression Spred3 0.05 0.02 2.2e-08 0.08 0.08 0.08 0.08 4.9e-08 5.8e-08 2.9e-08 3.1e-08
7 Adipose gene expression Spred3 0.11 0.07 2.2e-11 0.07 0.07 0.07 0.07 2.6e-08 4.4e-08 4.8e-08 2.9e-08
8 pVTA gene expression Spred3 0.11 0.08 1.9e-05 0.13 0.12 0.11 0.1 3.5e-06 1.2e-05 1.5e-05 5.7e-05
9 PL gene expression Spred3 0.07 0.06 3.1e-08 0.08 0.07 0.07 0.08 2.3e-09 1.3e-08 6.2e-08 6.0e-09
10 Brain mRNA stability Spred3 0.08 0.09 3.9e-05 0.05 0.04 0.05 0.04 1.8e-05 5.8e-05 1.1e-05 5.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.20.50.3-0.30.2-0.2-0.2-0.4-0.5-0.6-0.70.7
Area under the delay curve0.10.10.3-0.50.4-0.30.20.10.0-0.0-0.20.10.3
BMI with tail0.10.30.80.9-0.80.4-0.4-0.5-0.6-0.5-0.5-0.50.1
BMI without tail0.20.40.6-0.50.5-0.80.70.80.40.50.60.6-0.3
Body weight2.510.613.5-3.43.4-3.73.73.63.33.12.92.9-2.5
Weight adjusted by age0.20.20.40.5-0.50.5-0.5-0.5-0.4-0.3-0.2-0.20.6
Bone surface0.20.30.6-0.60.6-0.60.60.80.50.50.30.30.1
Bone volume0.20.30.6-0.60.6-0.70.70.80.50.50.30.3-0.0
Breakpoint value in progressive ratio session1.61.83.4-1.71.6-1.11.11.01.31.21.11.1-1.8
Number of licking bursts2.12.43.41.7-1.71.8-1.8-1.6-1.5-1.4-1.4-1.41.0
Context. condit. distance diff. score0.10.10.10.2-0.20.3-0.4-0.3-0.2-0.1-0.3-0.20.2
Locomotion velocity, session 12.32.52.91.5-1.61.7-1.7-1.7-1.6-1.6-1.6-1.70.9
Locomotion distance, session 10.81.01.1-1.01.0-1.01.01.11.01.01.00.9-0.9
Locomotion velocity, session 20.30.40.50.7-0.70.4-0.3-0.5-0.7-0.6-0.7-0.70.7
Locomotion distance, session 20.40.61.11.0-1.00.6-0.7-0.6-0.7-0.8-0.7-0.80.6
Locomotion velocity, session 30.20.20.30.6-0.50.5-0.6-0.5-0.3-0.3-0.3-0.30.0
Locomotion distance, session 35.96.47.4-2.52.5-2.62.52.72.62.72.62.6-1.9
Stereotopy head waving bouts, day 30.50.50.91.0-0.91.0-0.9-0.9-0.5-0.5-0.5-0.6-0.0
Stereotopy head waving duration, day 32.63.13.81.9-1.92.0-1.9-1.9-1.6-1.7-1.7-1.71.2
Locomotion velocity, session 70.00.00.1-0.10.0-0.10.20.1-0.00.0-0.2-0.20.2
Locomotion distance, session 70.10.10.3-0.30.3-0.40.50.30.30.30.20.2-0.1
Stereotopy head waving bouts, day 70.00.00.10.3-0.30.3-0.3-0.1-0.1-0.0-0.2-0.20.1
Stereotopy head waving duration, day 70.91.11.51.2-1.21.1-1.1-1.0-1.0-0.9-1.0-1.00.8
Locomotion velocity, session 82.93.54.62.1-2.11.9-2.0-1.9-1.7-1.8-2.0-2.01.0
Locomotion distance, session 80.30.40.60.8-0.70.6-0.7-0.6-0.6-0.5-0.7-0.70.4
Degree of sensitization distance3.43.44.11.7-1.81.8-1.7-2.0-1.9-2.0-2.0-2.01.5
Degree of sensitization stereotypy0.00.00.00.2-0.10.1-0.20.1-0.00.10.00.00.0
Conditioned locomotion0.40.40.7-0.30.4-0.40.50.80.80.80.80.8-0.8
Cocaine response after cond. corrected0.40.50.6-0.50.6-0.70.70.80.70.80.80.8-0.5
Cocaine response after cond. not corrected0.70.81.1-0.60.7-1.01.01.00.91.01.01.0-0.7
Cocaine response before conditioning1.72.02.4-1.11.2-1.51.51.41.51.51.51.5-1.3
Saline control response0.40.50.6-0.70.7-0.70.60.80.70.70.80.8-0.6
Bone: connectivity density0.61.01.80.8-0.90.8-0.8-0.7-1.1-1.0-1.1-1.21.3
Bone: cortical apparent density2.02.73.31.8-1.81.7-1.7-1.7-1.6-1.6-1.6-1.70.9
Bone: cortical area2.03.13.9-1.81.8-1.71.81.82.01.81.71.6-1.6
Bone: cortical porosity0.60.71.41.2-1.10.7-0.7-0.7-0.8-0.7-0.8-0.70.6
Bone: cortical porosity0.70.71.61.3-1.20.8-0.8-0.8-0.8-0.7-0.8-0.70.5
Bone: cortical thickness0.91.52.1-1.21.2-1.11.11.21.41.31.11.1-1.3
Bone: cortical thickness0.10.10.30.5-0.50.1-0.1-0.2-0.1-0.0-0.3-0.3-0.1
Bone: cortical tissue density2.43.23.92.0-1.91.8-1.8-1.9-1.7-1.8-1.8-1.91.0
Condit. Reinf. active minus inactive responses0.20.30.60.5-0.50.6-0.6-0.8-0.4-0.3-0.4-0.50.1
Condit. Reinf. active-inactive response ratio0.20.20.60.4-0.40.8-0.8-0.8-0.2-0.2-0.4-0.4-0.1
Condit. Reinf. active responses1.01.21.81.3-1.31.0-1.0-1.1-1.1-1.0-1.1-1.10.8
Condit. Reinf. inactive responses0.70.81.21.1-1.10.5-0.5-0.6-1.0-1.0-0.9-1.00.9
Incentive salience index mean0.00.00.10.2-0.20.0-0.0-0.2-0.00.0-0.1-0.10.0
Condit. Reinf. lever presses0.10.20.4-0.30.3-0.70.70.50.40.40.30.4-0.1
Condit. Reinf. active minus inactive responses4.35.46.2-2.32.3-2.22.22.22.42.52.52.5-2.0
Condit. Reinf. active-inactive response ratio3.13.24.2-1.51.6-1.61.61.71.92.02.02.0-2.0
Condit. Reinf. active responses4.96.87.6-2.72.7-2.62.62.52.72.72.72.8-2.2
Condit. Reinf. inactive responses1.51.82.6-1.61.5-1.51.51.31.31.21.31.3-0.7
Condit. Reinf. lever presses7.29.711.7-3.43.4-3.33.22.83.03.13.13.1-2.7
Condit. Reinf. lever reinforcers received5.98.39.2-2.92.9-2.82.82.82.93.03.03.0-2.5
Conditioned reinforcement - actives0.30.30.7-0.40.4-0.50.60.60.50.60.80.60.2
Conditioned reinforcement - inactives2.12.33.0-1.51.6-1.51.51.71.61.51.41.5-1.3
Conditioned locomotion1.11.32.41.4-1.31.1-1.1-1.1-1.1-0.8-0.8-1.01.5
Patch foraging indifference point 0 sec0.30.50.8-0.60.6-0.90.90.80.60.70.80.7-0.4
Patch foraging indifference point AUC0.50.61.20.8-0.70.7-0.6-0.6-0.7-0.8-1.0-1.10.6
Delay disc. indifference point, 0s delay0.60.71.4-0.90.8-1.21.00.90.70.50.70.70.1
Delay disc. indifference point, 16s delay1.41.42.3-1.41.3-1.41.51.31.01.11.01.1-0.3
Delay disc. indifference point, 2s delay0.10.10.2-0.50.30.1-0.1-0.1-0.1-0.3-0.3-0.10.4
Delay disc. indifference point, 24s delay1.21.21.8-1.31.3-1.31.21.31.01.00.60.8-0.7
Delay disc. indifference point, 4s delay0.10.10.2-0.40.3-0.40.30.20.20.10.10.3-0.1
Delay disc. indifference point, 8s delay0.80.91.60.6-0.70.9-0.9-1.1-1.0-1.1-1.3-1.00.7
Indifference point function ln k0.50.60.8-0.80.8-0.80.80.80.80.80.90.9-0.7
Indifference point function log k0.50.60.8-0.80.8-0.80.80.80.80.80.90.9-0.7
Patch foraging total patch changes 0 sec0.40.60.9-0.70.7-1.00.90.80.80.80.90.8-0.6
Patch foraging total patch changes 12 sec0.30.40.9-0.50.5-0.90.90.80.60.50.50.4-0.2
Patch foraging total patch changes 18 sec0.10.20.50.4-0.40.2-0.2-0.2-0.3-0.5-0.5-0.70.3
Patch foraging total patch changes 24 sec0.60.71.1-0.90.9-1.11.10.90.80.70.70.6-0.2
Patch foraging total patch changes 6 sec0.10.10.4-0.20.2-0.60.60.50.30.20.20.2-0.1
Patch foraging time to switch 0 sec1.11.72.31.2-1.31.1-1.1-1.2-1.4-1.4-1.5-1.41.3
Patch foraging water rate 0 sec0.40.61.00.9-0.91.0-1.0-0.9-0.7-0.7-0.7-0.80.1
Patch foraging water rate 12 sec0.81.32.7-1.21.2-0.90.91.01.11.21.01.0-1.6
Patch foraging water rate 18 sec0.60.71.30.7-0.71.1-1.1-1.1-0.9-0.8-0.8-0.80.1
Patch foraging water rate 24 sec0.50.72.9-0.70.7-0.30.20.40.81.00.90.9-1.7
Patch foraging water rate 6 sec0.10.10.4-0.50.40.10.00.00.30.20.30.3-0.7
Seeking ratio, delayed vs. immediate footshock1.21.42.1-1.31.3-1.21.21.01.21.11.01.0-1.4
Distance traveled before self-admin2.22.34.9-1.41.4-1.41.31.31.41.61.41.5-2.2
Distance traveled after self-admin5.05.66.7-2.62.6-2.32.32.42.32.42.42.4-1.9
Extensor digitorum longus weight0.20.70.90.9-0.90.7-0.6-0.9-0.9-0.9-0.8-0.90.9
Bone: elastic displacement0.10.10.10.2-0.20.1-0.1-0.3-0.3-0.2-0.3-0.40.2
Bone: elastic work2.22.83.3-1.71.7-1.81.81.71.81.81.61.5-1.6
Bone: endosteal estimation1.12.43.1-1.71.7-1.71.81.71.51.51.41.4-0.9
Bone: endosteal perimeter1.02.02.9-1.71.7-1.61.61.51.41.31.31.3-0.6
Epididymis fat weight0.00.00.10.2-0.2-0.10.0-0.0-0.2-0.1-0.2-0.10.3
Delta time in closed arm before/after self-admin0.70.61.4-0.80.8-1.11.21.10.60.60.50.50.3
Delta time in open arm before/after self-admin0.20.20.40.4-0.30.6-0.6-0.5-0.0-0.1-0.0-0.0-0.7
Diff in mean of infusions in LGA sessions0.10.20.8-0.50.4-0.10.2-0.00.40.30.20.2-0.9
Delay discount exponential model param0.10.10.30.5-0.40.3-0.2-0.1-0.1-0.00.2-0.1-0.1
Extinction: sum of active levers before priming1.21.21.7-1.21.2-1.21.31.21.10.91.01.0-0.7
Active lever presses in extinction session 60.30.30.7-0.80.8-0.70.70.60.50.40.20.20.1
Bone: final force1.72.73.4-1.71.7-1.71.71.71.81.81.51.5-1.4
Bone: final moment2.54.15.0-2.02.0-2.02.12.12.22.11.91.9-1.8
Food consumed during 24 hour testing period0.30.40.6-0.70.7-0.60.60.50.60.70.70.7-0.3
Glucose0.30.50.80.7-0.70.4-0.4-0.5-0.8-0.8-0.9-0.80.7
Heart weight0.71.01.3-0.90.9-0.91.01.01.10.91.11.1-0.9
Delay discount hyperbolic model param0.00.00.20.4-0.30.1-0.10.00.00.10.3-0.0-0.2
Intermittent access intake day 1-15 change1.31.32.4-1.21.2-1.51.51.51.01.00.80.80.0
Intermittent access intake escalation1.01.01.6-1.11.1-1.31.21.30.80.90.90.80.0
Intermittent access intake escalation 23.23.24.2-1.81.8-2.02.12.01.71.81.71.7-1.2
Intermitt. access day 1 inactive lever presses0.40.40.8-0.90.8-0.80.80.80.40.40.30.20.2
Intermitt. access day 15 inactive lever presses0.20.20.4-0.60.6-0.50.60.50.30.30.30.10.1
Intermitt. access escalation Index0.30.31.4-0.30.3-0.0-0.00.00.40.60.60.6-1.2
Intermittent access day 1 total infusions0.20.20.80.4-0.30.5-0.5-0.40.10.40.70.4-0.9
Intermittent access day 15 total infusions0.91.01.9-0.90.9-0.90.80.91.01.21.41.1-0.9
Intermittent access terminal intake (last 3 days)1.51.72.4-1.11.2-1.21.21.21.41.51.51.3-1.3
Intermittent access total infusions0.70.71.6-0.60.6-0.50.50.60.91.11.31.1-1.0
Intermittent access day 1 locomotion0.10.10.60.3-0.20.2-0.2-0.10.10.30.80.5-0.1
Intermittent access day 15 total locomotion0.10.10.50.2-0.2-0.20.20.1-0.2-0.00.1-0.10.7
Intermittent access total locomotion0.40.41.30.8-0.80.5-0.4-0.4-0.6-0.5-0.2-0.51.1
Intermittent access standard deviation4.54.86.5-2.62.5-2.22.12.22.22.32.02.0-1.7
Left kidney weight2.77.68.9-2.52.6-2.92.93.02.92.62.72.7-2.4
Right kidney weight4.011.312.7-3.43.4-3.63.63.53.43.23.33.3-2.8
Cocaine induced anxiety0.00.00.0-0.20.10.0-0.0-0.20.1-0.10.1-0.0-0.0
Post-drug Anxiety0.40.40.90.4-0.50.5-0.5-0.7-0.6-0.8-0.5-0.61.0
Baseline Anxiety0.10.10.30.6-0.50.4-0.4-0.2-0.3-0.2-0.2-0.10.1
Tail length4.714.318.0-4.24.2-4.03.94.13.83.63.53.5-2.7
Length with tail7.125.931.9-5.65.6-5.55.45.45.24.94.64.6-3.6
Length without tail3.37.28.8-3.03.0-2.82.82.72.92.62.42.4-2.3
Times rat made contact with spout0.40.40.70.9-0.80.6-0.6-0.5-0.6-0.6-0.6-0.60.5
Lifetime Intake0.10.20.70.00.00.00.00.10.30.60.80.6-0.5
Liver weight, left0.10.10.50.6-0.5-0.20.20.0-0.3-0.3-0.3-0.30.7
Liver weight, right0.00.00.1-0.00.0-0.30.30.10.10.2-0.00.1-0.1
Locomotor activity0.40.71.11.0-0.90.6-0.6-0.5-0.8-1.0-1.0-1.00.4
Locomotor testing distance0.81.31.81.3-1.31.2-1.2-1.1-1.2-1.3-1.1-1.20.5
Locomotor testing rearing1.21.92.71.6-1.61.3-1.3-1.3-1.4-1.6-1.4-1.40.5
Locomotion in novel chamber0.30.40.60.5-0.60.5-0.5-0.5-0.8-0.7-0.6-0.70.7
Locomotion in novel chamber post-restriction0.10.10.6-0.40.30.4-0.3-0.10.1-0.0-0.00.0-0.8
Fecal boli incidents, locomotor time 13.03.24.21.7-1.81.7-1.6-2.0-2.1-2.0-1.7-1.61.7
Change in fecal boli incidents, locomotor task0.20.20.4-0.40.4-0.30.20.50.50.60.50.4-0.4
Time >=10cm from walls, locomotor time 10.00.00.10.1-0.10.1-0.1-0.0-0.2-0.4-0.3-0.30.1
Bouts of movement, locomotor time 10.20.20.9-1.00.8-0.30.50.40.30.10.30.2-0.2
Total resting periods, locomotor time 10.10.20.8-0.90.7-0.20.30.30.10.00.20.1-0.2
Rest time, locomotor task time 10.00.00.10.2-0.20.2-0.1-0.1-0.3-0.3-0.0-0.00.2
Distance moved, locomotor task time 10.10.10.3-0.10.2-0.50.20.50.40.60.30.2-0.1
Vertical activity count, locomotor time 11.11.11.5-1.01.1-1.10.91.21.21.21.11.1-0.7
Time >=10cm from walls, locomotor time 20.00.00.10.00.0-0.30.20.00.2-0.00.1-0.1-0.1
Bouts of movement, locomotor time 20.30.31.30.1-0.2-0.00.2-0.3-0.4-0.9-0.5-0.71.1
Total resting periods, locomotor time 20.30.31.10.2-0.30.10.1-0.3-0.5-0.9-0.6-0.71.0
Rest time, locomotor task time 20.20.30.9-0.40.4-0.00.20.60.50.70.40.5-0.9
Distance moved, locomotor task time 20.10.10.30.3-0.3-0.2-0.1-0.1-0.2-0.2-0.0-0.30.5
Vertical activity count, locomotor time 20.10.20.5-0.50.4-0.70.50.30.20.20.30.20.2
Light reinforcement 10.20.30.60.5-0.50.1-0.2-0.3-0.6-0.7-0.8-0.80.6
Light reinforcement 26.79.09.92.9-3.03.1-3.1-3.0-3.2-3.0-3.0-2.92.5
Bone: marrow area1.22.53.2-1.81.7-1.81.81.71.51.51.41.4-0.9
Bone: maximum diameter1.42.53.1-1.61.6-1.81.81.71.71.61.41.4-0.9
Bone: maximum force2.84.85.7-2.32.3-2.22.22.32.42.42.12.0-1.9
Bone: maximum moment3.76.47.5-2.62.6-2.62.62.62.72.72.42.3-2.2
Mean time between licks in bursts0.20.20.3-0.40.4-0.60.60.50.60.50.40.5-0.1
Mean num. licks in bursts0.80.91.5-1.01.0-1.21.21.10.90.80.80.8-0.5
Cd content in liver0.40.40.70.5-0.50.8-0.8-0.8-0.6-0.6-0.6-0.60.3
Co content in liver1.82.12.61.5-1.51.5-1.5-1.6-1.4-1.4-1.4-1.41.0
Cu content in liver1.21.51.8-1.11.2-1.21.21.21.31.21.31.3-1.0
Fe content in liver0.30.40.60.5-0.50.5-0.5-0.6-0.7-0.8-0.8-0.70.7
K content in liver0.70.70.9-0.60.7-0.91.00.90.90.80.90.9-0.6
Mg content in liver0.10.10.10.1-0.0-0.20.20.20.30.20.30.3-0.3
Mn content in liver0.50.60.9-0.20.3-0.60.70.80.90.90.90.9-1.0
Na content in liver5.45.77.0-2.32.3-2.62.62.62.42.42.42.4-1.7
Rb content in liver0.00.00.1-0.10.1-0.30.30.1-0.0-0.1-0.0-0.00.1
Se content in liver3.13.86.12.5-2.42.1-2.1-1.8-1.8-1.8-1.8-1.81.1
Sr content in liver0.70.71.00.9-0.91.0-1.0-0.9-0.8-0.7-0.7-0.60.4
Zn content in liver0.30.30.50.6-0.60.7-0.7-0.7-0.5-0.6-0.5-0.50.3
Bone: minimum diameter5.410.211.5-3.33.3-3.23.23.23.43.33.23.1-2.7
Time in familiar zone, hab. session 10.30.30.5-0.50.5-0.70.70.60.50.50.40.4-0.1
Time in novel zone, hab. session 10.10.10.30.4-0.40.5-0.5-0.5-0.3-0.3-0.2-0.2-0.1
Total zone transitions, hab. session 10.50.71.3-0.70.8-1.11.11.00.80.80.80.7-0.5
Total locomotion distance, hab. session 12.94.25.3-2.22.1-2.32.32.12.02.02.02.0-1.3
Locomotion velocity, hab. session 11.31.82.4-1.41.4-1.51.51.41.31.31.31.3-0.8
Time in familiar zone, hab. session 20.40.40.9-1.00.9-0.50.50.50.70.70.50.7-0.2
Time in novel zone, hab. session 20.60.60.90.9-0.90.6-0.7-0.7-0.8-0.9-0.7-0.80.3
Total zone transitions, hab. session 20.00.10.30.6-0.50.1-0.1-0.1-0.00.0-0.1-0.10.1
Total locomotion distance, hab. session 20.40.50.8-0.60.7-0.80.70.70.90.90.80.8-0.5
Locomotion velocity, hab. session 20.30.50.7-0.50.5-0.70.70.70.80.90.70.8-0.5
Novel to familiar place preference ratio1.11.11.5-1.01.1-1.11.11.21.00.91.11.0-1.0
Novelty place preference1.01.01.4-0.91.0-1.11.11.20.90.91.00.9-1.0
Time in novel zone, NPP test0.60.60.9-0.70.7-0.80.91.00.70.70.80.7-0.9
Total zone transitions, NPP test0.20.20.60.5-0.50.2-0.3-0.4-0.5-0.4-0.5-0.50.8
Total locomotion distance, NPP test1.62.22.9-1.71.7-1.61.51.41.51.51.41.4-0.8
Locomotion velocity, NPP test2.02.93.7-1.91.9-1.81.71.71.71.71.71.6-1.0
Intraocular pressure0.10.10.30.1-0.10.4-0.4-0.1-0.4-0.4-0.4-0.50.3
Delta distance traveled before/after self-admin0.50.51.2-1.11.0-0.70.80.80.60.50.60.60.4
Delta ambulatory time before/after self-admin1.01.11.7-1.31.3-1.01.11.11.01.01.11.1-0.1
Parametrial fat weight0.61.11.61.3-1.21.0-1.0-0.9-1.0-1.1-1.0-0.90.9
Pavlov. Cond. lever latency0.20.20.40.2-0.20.7-0.6-0.5-0.5-0.5-0.4-0.50.3
Pavlov. Cond. magazine entry latency0.10.10.20.4-0.40.3-0.4-0.4-0.3-0.3-0.3-0.3-0.0
Pavlov. Cond. change in total contacts0.00.00.00.0-0.0-0.10.00.00.00.00.00.0-0.0
Pavlov. Cond. index score0.00.00.10.2-0.1-0.30.20.10.10.10.10.1-0.1
Pavlov. Cond. latency score0.10.10.2-0.00.1-0.40.40.30.30.30.30.3-0.1
Pavlov. Cond. lever contacts0.81.01.7-0.80.8-1.31.31.11.01.00.91.0-0.6
Pavlov. Cond. magazine entry number0.00.00.1-0.30.3-0.20.20.30.20.10.10.10.2
Pavlov. Cond. intertrial magazine entries0.10.20.30.5-0.50.5-0.4-0.3-0.3-0.4-0.4-0.30.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.00.1-0.50.40.40.40.40.30.4-0.3
Pavlov. Cond. response bias0.10.10.3-0.20.2-0.50.50.30.40.40.40.4-0.4
Pavlov. Cond. lever latency3.24.35.62.4-2.32.1-2.1-1.9-2.0-2.0-2.0-2.01.8
Pavlov. Cond. magazine entry latency1.72.02.7-1.71.6-1.51.61.31.31.31.31.3-0.9
Pavlov. Cond. change in total contacts6.28.610.8-3.33.2-2.92.92.72.92.92.92.9-2.5
Pavlov. Cond. index score2.93.75.0-2.22.2-2.12.11.81.81.81.81.8-1.5
Pavlov. Cond. latency score2.73.44.6-2.12.1-2.02.01.71.71.81.81.8-1.5
Pavlov. Cond. lever contacts3.14.25.4-2.32.3-2.12.11.92.02.02.02.0-1.8
Pavlov. Cond. magazine entry number1.11.32.21.5-1.41.3-1.3-1.1-1.0-1.0-1.0-1.00.7
Pavlov. Cond. intertrial magazine entries0.81.11.71.3-1.21.2-1.2-1.2-0.9-0.9-0.9-0.90.4
Pavlov. Cond. lever-magazine prob. diff.3.34.25.4-2.32.3-2.22.22.01.92.02.02.0-1.6
Pavlov. Cond. response bias3.54.86.0-2.42.4-2.22.22.02.12.12.22.2-1.9
Time in closed arm before self-admin0.20.31.30.3-0.30.6-0.7-0.6-0.10.20.10.1-1.2
Time in closed arm after self-admin0.30.30.4-0.60.5-0.60.70.50.30.60.50.6-0.5
Time in open arm before self-admin1.11.22.0-1.21.2-1.31.41.31.20.90.90.9-0.4
Time in open arm after self-admin0.70.71.3-0.70.8-0.80.81.01.10.80.80.7-1.0
Bone: periosteal estimation1.94.04.6-2.12.1-2.12.22.12.12.01.91.8-1.5
Bone: periosteal perimeter1.72.83.5-1.91.9-1.81.81.81.71.61.61.5-1.1
Bone: post-yield work0.71.01.4-1.21.1-0.91.00.91.00.91.01.0-0.6
Progressive ratio test 1 active lever presses2.12.23.7-1.11.2-1.11.11.31.41.71.91.7-1.9
Progressive ratio test 1 breakpoint2.62.74.2-1.41.4-1.41.31.51.61.72.01.8-2.1
Progressive ratio test 1 inactive lever presses0.30.30.5-0.70.7-0.40.50.60.50.60.70.60.2
Progressive ratio test 2 active lever presses0.70.71.5-0.80.8-0.80.80.80.80.91.20.9-0.7
Progressive ratio test 2 breakpoint0.70.81.6-0.80.8-0.80.80.80.91.01.31.0-0.8
Progressive ratio test 2 inactive lever presses2.63.04.0-2.02.0-1.71.71.71.71.81.71.5-1.3
Incentive Sensitization - Responses0.00.00.1-0.10.1-0.20.20.0-0.0-0.2-0.0-0.30.4
Incentive Sensitization - Breakpoint0.10.10.40.1-0.10.00.1-0.2-0.2-0.4-0.3-0.50.6
Sum of active levers in priming session hrs 5-60.00.00.2-0.10.1-0.10.10.00.40.1-0.1-0.1-0.4
Progressive ratio0.60.72.50.5-0.60.6-0.5-0.5-0.9-0.8-0.9-0.91.6
Food seeking constrained by brief footshock3.03.74.3-2.12.1-1.81.81.61.92.02.02.0-1.8
Seeking ratio, punishment vs. effort2.32.86.3-1.51.6-1.31.21.21.81.71.81.8-2.5
Retroperitoneal fat weight1.03.34.72.2-2.11.5-1.5-1.4-1.9-2.1-2.0-1.91.3
Reaction time number correct0.10.10.30.1-0.0-0.10.20.10.30.40.40.3-0.5
Reaction time mean minus median0.20.30.5-0.50.5-0.50.50.50.60.60.60.6-0.7
Reaction time mean minus median AUC0.40.50.9-0.60.6-0.70.70.60.80.60.70.8-0.9
Reaction time num false alarms0.91.21.61.2-1.21.0-1.0-0.9-1.1-1.1-1.0-1.11.2
Reaction time num false alarms AUC1.21.72.21.5-1.41.2-1.3-1.1-1.3-1.3-1.2-1.31.4
Reaction time trials correct on left0.10.10.30.1-0.0-0.10.20.10.30.40.40.3-0.5
Reaction time trials on left0.10.10.30.1-0.0-0.00.10.10.30.40.40.3-0.5
Reaction time mean0.00.10.10.3-0.30.3-0.3-0.3-0.2-0.1-0.00.0-0.3
Reaction time mean AUC0.10.10.30.5-0.50.4-0.4-0.4-0.3-0.3-0.2-0.1-0.1
Median of all reaction times0.10.20.30.5-0.50.5-0.5-0.5-0.4-0.3-0.3-0.20.0
Reaction time omissions0.10.20.30.5-0.50.5-0.6-0.6-0.3-0.3-0.2-0.20.2
Reaction time false alarm rate1.21.62.41.2-1.31.1-1.2-1.0-1.3-1.4-1.3-1.31.6
Reaction time premature initiation rate0.00.00.1-0.20.20.00.0-0.10.1-0.0-0.1-0.2-0.2
Reaction time premature initiations0.00.00.3-0.10.10.00.1-0.00.20.20.1-0.0-0.5
Std. dev. reaction times0.20.20.8-0.30.3-0.20.20.30.50.50.50.5-0.9
Reaction time trials completed0.10.10.30.1-0.0-0.00.10.10.30.40.40.3-0.5
Reaction time trials AUC0.00.10.20.3-0.20.1-0.0-0.00.20.40.30.2-0.5
Run reversals in cocaine runway, females0.30.30.40.5-0.50.5-0.5-0.4-0.6-0.6-0.5-0.50.6
Run reversals in cocaine runway, males1.00.91.61.1-1.11.2-1.2-1.2-0.8-0.8-0.7-0.8-0.4
Latency to leave start box in cocaine runway0.20.20.60.2-0.20.2-0.10.0-0.3-0.3-0.8-0.70.6
Latency to leave start box in cocaine runway, F0.60.61.30.7-0.70.8-0.6-0.7-0.6-0.7-1.1-1.00.7
Latency to leave start box in cocaine runway, M0.10.10.3-0.30.3-0.20.20.50.10.2-0.0-0.00.1
Std. dev. time between licks in bursts0.60.81.1-1.01.0-1.11.11.10.80.80.70.70.0
Total sessions with >9 infusions0.10.10.30.6-0.50.2-0.2-0.1-0.00.30.50.4-0.1
Short access day 1 total inactive lever presses0.40.40.8-0.90.8-0.70.70.70.60.60.60.5-0.1
Short access day 10 total inactive lever presses0.20.30.6-0.80.7-0.50.60.50.30.50.40.30.3
Short access day 1 total infusions0.40.51.4-0.40.4-0.40.40.50.70.80.80.8-1.2
Short access day 10 total infusions0.20.20.40.5-0.50.6-0.6-0.6-0.20.10.30.1-0.1
Short access total infusions0.20.20.50.7-0.60.5-0.5-0.5-0.2-0.10.30.1-0.0
Short access day 1 locomotion1.51.63.01.5-1.50.9-1.0-1.1-1.2-1.2-1.0-1.21.7
Short access day 10 total locomotion0.50.61.1-0.50.5-0.90.80.90.60.71.11.00.5
Short access total locomotion0.30.31.30.7-0.70.1-0.1-0.2-0.4-0.30.20.01.1
One hour access (0.3 mA shock)1.51.83.2-1.41.3-1.31.41.31.21.51.81.5-0.5
Compulsive drug intake0.30.30.5-0.70.7-0.40.40.40.50.50.60.5-0.3
One hour access (shock baseline)0.30.30.7-0.40.4-0.50.60.50.40.60.80.7-0.1
Social response proportion4.95.37.2-2.22.3-2.12.02.02.32.52.62.7-2.2
Social responses0.10.10.2-0.40.4-0.40.40.30.20.20.50.5-0.2
Social time0.40.51.2-1.11.0-0.60.60.50.50.50.70.8-0.6
Soleus weight0.82.42.91.4-1.51.4-1.4-1.6-1.7-1.5-1.7-1.61.4
Bone: stiffness1.42.22.8-1.61.6-1.41.41.51.71.71.41.4-1.2
Tibialis anterior weight0.00.00.10.1-0.1-0.30.20.1-0.0-0.00.20.10.1
Time to tail flick, vehicle, before self-admin0.20.20.50.2-0.1-0.70.70.70.30.40.20.20.5
Time to tail flick, vehicle, after self-admin0.20.31.1-0.60.6-0.20.20.20.20.40.40.5-1.0
Time to tail flick, test, before self-admin0.10.10.30.1-0.1-0.50.50.60.20.10.00.10.2
Time to tail flick, test, after self-admin0.10.10.30.1-0.1-0.20.30.10.20.10.30.30.6
Delta time to tail flick, vehicle, before/after SA0.20.21.2-0.60.50.0-0.1-0.00.20.30.50.4-1.1
Delta time to tail flick, test, before/after SA0.00.00.10.2-0.10.3-0.2-0.40.00.10.20.10.2
Tibia length2.05.76.6-2.42.4-2.52.62.42.42.42.42.3-1.9
Ambulatory time before self-admin1.31.33.5-1.11.1-1.00.90.91.01.21.01.1-1.9
Ambulatory time after self-admin5.35.87.6-2.82.7-2.22.22.32.32.52.42.5-2.1
Bone: tissue strength4.24.14.6-2.12.1-1.91.92.12.12.12.12.1-1.7
Total heroin consumption1.51.72.5-1.41.4-1.21.31.21.51.21.21.2-1.6
Bone: trabecular number0.10.10.3-0.40.3-0.60.60.50.20.20.20.10.3
Bone: trabecular spacing1.72.22.6-1.51.5-1.41.41.51.51.61.51.6-1.4
Bone: trabecular thickness0.20.20.40.6-0.60.3-0.3-0.4-0.4-0.5-0.6-0.60.4
Bone: trabecular tissue density2.53.63.92.0-2.01.9-1.9-1.9-1.9-2.0-1.9-2.01.3
Water consumed over 24 hours0.70.91.3-0.80.8-1.01.01.11.01.11.11.1-0.4
Number of responses in last shaping day2.22.32.9-1.51.5-1.51.41.61.61.61.41.4-1.7