Hub : Genes

Spmap2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Spmap2 0.58 0.18 5.5e-13 0.25 0.27 0.28 0.28 8.7e-07 3.1e-07 1.8e-07 2.6e-07
2 OFC gene expression Spmap2 0.46 0.19 4.1e-11 0.35 0.39 0.38 0.38 3.4e-09 3.2e-10 5.5e-10 6.1e-10
3 BLA gene expression Spmap2 0.15 0.09 3.7e-10 0.14 0.18 0.18 0.18 4.5e-08 3.5e-10 9.4e-10 4.5e-10
4 NAcc gene expression Spmap2 0.24 0.11 0.0e+00 0.32 0.34 0.34 0.34 7.0e-38 2.0e-40 1.4e-40 1.0e-40
5 PL intron excision ratio chr7_10153699_10158385 0.02 0.02 1.3e-03 0.04 0.02 0.03 0.02 7.9e-05 2.8e-03 7.3e-04 1.5e-03
6 LHb gene expression Spmap2 0.27 0.15 2.1e-06 0.22 0.21 0.22 0.21 6.0e-06 9.8e-06 6.7e-06 8.0e-06
7 PL gene expression Spmap2 0.27 0.11 0.0e+00 0.41 0.42 0.42 0.42 7.4e-48 9.1e-50 1.9e-49 1.5e-49
8 PL intron excision ratio chr7_10117498_10126864 0.06 0.04 6.4e-10 0.09 0.09 0.08 0.09 6.1e-10 4.4e-10 2.7e-09 1.2e-09
9 PL intron excision ratio chr7_10154221_10158385 0.03 0.02 4.7e-04 0.03 0.03 0.03 0.03 4.5e-04 1.8e-04 3.3e-04 2.1e-04
10 Brain gene expression Spmap2 0.19 0.11 0.0e+00 0.17 0.18 0.16 0.17 1.1e-15 3.6e-16 4.6e-15 1.3e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.50.82.1-0.0-0.2-0.4-0.6-1.00.8-1.0-1.11.2-1.4
Area under the delay curve2.32.52.91.7-1.6-1.6-1.6-1.61.6-1.6-1.51.5-1.4
BMI with tail6.420.823.94.9-4.9-4.8-4.6-4.54.5-4.5-4.44.3-4.1
BMI without tail1.83.76.12.5-2.3-2.1-2.0-1.72.0-1.8-1.71.6-1.4
Body weight1.14.55.72.4-2.3-2.2-2.3-2.12.2-2.1-2.02.0-1.8
Weight adjusted by age0.30.30.80.9-0.8-0.8-0.6-0.50.4-0.4-0.40.3-0.2
Bone surface0.20.41.4-0.80.40.2-0.0-0.50.4-0.6-0.80.9-1.2
Bone volume0.30.51.7-0.60.30.0-0.2-0.60.5-0.7-0.91.0-1.3
Breakpoint value in progressive ratio session6.06.67.0-2.52.52.62.62.5-2.72.62.6-2.62.5
Number of licking bursts0.10.10.20.4-0.3-0.2-0.10.1-0.00.10.2-0.30.4
Context. condit. distance diff. score0.00.00.20.4-0.2-0.1-0.1-0.00.4-0.1-0.00.00.1
Locomotion velocity, session 10.20.20.7-0.90.70.60.50.3-0.50.30.2-0.20.0
Locomotion distance, session 10.20.30.8-0.90.90.70.60.30.20.10.00.1-0.1
Locomotion velocity, session 24.04.77.1-2.62.72.52.42.1-1.72.01.9-1.71.6
Locomotion distance, session 20.81.13.1-1.81.51.31.20.8-0.90.70.6-0.50.2
Locomotion velocity, session 38.09.39.9-2.93.03.13.13.1-2.93.13.1-3.13.1
Locomotion distance, session 30.10.10.2-0.00.10.20.20.3-0.10.30.3-0.30.4
Stereotopy head waving bouts, day 36.27.38.5-2.82.92.92.82.7-2.42.72.6-2.52.5
Stereotopy head waving duration, day 37.08.49.3-3.03.13.03.02.9-2.72.92.8-2.82.7
Locomotion velocity, session 71.31.42.3-0.81.11.21.31.4-0.61.31.3-1.31.5
Locomotion distance, session 70.10.10.30.5-0.4-0.2-0.10.00.30.00.1-0.10.3
Stereotopy head waving bouts, day 70.00.00.2-0.40.40.30.20.10.00.00.00.1-0.1
Stereotopy head waving duration, day 70.10.20.5-0.70.60.60.50.3-0.30.30.2-0.10.0
Locomotion velocity, session 80.70.91.7-1.21.31.21.11.0-0.40.80.7-0.60.7
Locomotion distance, session 80.30.40.7-0.80.80.80.70.6-0.30.50.5-0.40.4
Degree of sensitization distance0.30.30.60.7-0.5-0.5-0.5-0.50.8-0.5-0.50.5-0.4
Degree of sensitization stereotypy2.12.32.71.3-1.4-1.5-1.5-1.61.5-1.6-1.61.6-1.7
Conditioned locomotion1.01.22.21.5-1.4-1.3-1.2-1.01.0-0.9-0.80.8-0.6
Cocaine response after cond. corrected4.85.38.02.8-2.8-2.6-2.5-2.32.1-2.1-2.01.9-1.7
Cocaine response after cond. not corrected4.85.38.12.8-2.8-2.6-2.5-2.22.1-2.1-2.01.9-1.7
Cocaine response before conditioning0.70.81.0-0.91.01.01.01.0-0.70.90.9-0.90.9
Saline control response0.00.10.10.3-0.3-0.3-0.3-0.20.2-0.2-0.20.2-0.2
Bone: connectivity density0.71.02.10.4-0.6-0.7-0.8-1.11.0-1.1-1.21.3-1.5
Bone: cortical apparent density1.31.82.01.3-1.4-1.4-1.4-1.41.1-1.3-1.31.3-1.3
Bone: cortical area0.71.01.60.9-0.8-0.9-0.9-1.01.3-1.1-1.11.1-1.1
Bone: cortical porosity0.30.30.7-0.80.70.70.60.5-0.50.50.4-0.40.3
Bone: cortical porosity0.00.00.1-0.30.20.10.1-0.10.2-0.2-0.20.3-0.3
Bone: cortical thickness1.42.32.51.4-1.4-1.5-1.5-1.51.6-1.6-1.61.6-1.6
Bone: cortical thickness0.00.00.10.3-0.2-0.2-0.10.1-0.20.10.2-0.30.3
Bone: cortical tissue density1.01.31.51.1-1.2-1.2-1.2-1.20.8-1.1-1.11.1-1.2
Condit. Reinf. active minus inactive responses5.46.16.5-2.52.52.52.52.5-2.42.52.4-2.42.3
Condit. Reinf. active-inactive response ratio2.32.53.4-1.51.51.51.51.5-1.81.61.6-1.71.5
Condit. Reinf. active responses3.94.86.6-2.62.52.42.32.2-2.02.12.0-1.91.8
Condit. Reinf. inactive responses0.70.81.8-1.31.31.11.00.8-0.60.70.6-0.50.4
Incentive salience index mean2.83.44.4-2.12.12.02.01.8-1.61.81.7-1.61.6
Condit. Reinf. lever presses0.10.20.4-0.50.40.20.1-0.20.4-0.3-0.40.5-0.6
Condit. Reinf. active minus inactive responses2.02.53.3-1.41.31.41.41.6-1.81.61.7-1.71.7
Condit. Reinf. active-inactive response ratio0.10.10.20.2-0.3-0.3-0.3-0.1-0.5-0.00.0-0.10.0
Condit. Reinf. active responses1.92.73.0-1.41.51.51.61.7-1.71.71.7-1.71.7
Condit. Reinf. inactive responses1.51.92.4-1.11.31.41.41.5-1.11.41.5-1.41.5
Condit. Reinf. lever presses2.23.03.7-1.61.61.61.71.7-1.91.81.8-1.81.8
Condit. Reinf. lever reinforcers received1.42.02.5-1.11.21.31.31.5-1.61.51.5-1.61.6
Conditioned reinforcement - actives1.81.82.4-1.61.51.41.31.2-1.41.31.3-1.31.2
Conditioned reinforcement - inactives0.20.30.50.7-0.6-0.6-0.6-0.60.5-0.5-0.40.4-0.3
Conditioned locomotion6.98.39.4-3.13.03.03.02.7-2.92.82.8-2.72.6
Patch foraging indifference point 0 sec0.30.40.50.5-0.6-0.6-0.7-0.70.6-0.7-0.70.7-0.7
Patch foraging indifference point AUC0.60.70.9-0.90.90.90.90.8-1.00.90.8-0.90.8
Delay disc. indifference point, 0s delay8.79.511.72.6-2.7-2.9-2.9-3.13.2-3.3-3.33.4-3.4
Delay disc. indifference point, 16s delay0.10.10.20.4-0.3-0.3-0.4-0.50.3-0.3-0.30.3-0.3
Delay disc. indifference point, 2s delay5.86.57.42.5-2.5-2.5-2.5-2.52.7-2.6-2.52.6-2.4
Delay disc. indifference point, 24s delay0.90.91.21.1-1.0-1.0-0.9-1.10.8-0.9-0.80.8-0.7
Delay disc. indifference point, 4s delay0.90.91.21.0-0.9-0.9-0.9-1.11.0-1.0-0.91.0-0.9
Delay disc. indifference point, 8s delay1.11.21.91.4-1.2-1.2-1.2-1.01.1-1.0-0.90.9-0.8
Indifference point function ln k0.20.30.40.7-0.6-0.6-0.5-0.50.5-0.5-0.40.4-0.3
Indifference point function log k0.20.30.40.7-0.6-0.6-0.5-0.50.5-0.5-0.40.4-0.3
Patch foraging total patch changes 0 sec0.10.20.30.4-0.5-0.5-0.5-0.50.4-0.5-0.50.5-0.5
Patch foraging total patch changes 12 sec0.30.40.60.7-0.8-0.7-0.7-0.60.5-0.6-0.60.5-0.5
Patch foraging total patch changes 18 sec1.01.31.5-1.21.21.11.21.1-1.21.11.1-1.11.0
Patch foraging total patch changes 24 sec0.00.00.0-0.20.10.10.20.0-0.20.00.0-0.0-0.0
Patch foraging total patch changes 6 sec0.00.10.2-0.50.30.20.10.2-0.50.20.1-0.2-0.0
Patch foraging time to switch 0 sec1.11.72.60.8-0.9-1.0-1.0-1.31.6-1.4-1.51.6-1.6
Patch foraging water rate 0 sec0.10.20.80.4-0.2-0.0-0.00.4-0.30.50.6-0.70.9
Patch foraging water rate 12 sec0.81.22.81.7-1.5-1.3-1.3-0.90.9-0.8-0.70.6-0.4
Patch foraging water rate 18 sec0.40.51.50.3-0.10.10.10.7-0.70.80.9-1.11.2
Patch foraging water rate 24 sec0.20.31.21.1-0.9-0.7-0.6-0.10.10.00.2-0.30.5
Patch foraging water rate 6 sec0.50.71.5-0.10.30.50.60.9-0.80.91.0-1.11.2
Seeking ratio, delayed vs. immediate footshock4.14.85.5-2.32.42.32.22.1-2.12.22.1-2.12.0
Distance traveled before self-admin0.91.01.30.8-0.9-1.0-1.0-0.90.9-1.0-1.11.1-1.2
Distance traveled after self-admin0.40.40.6-0.80.70.70.60.7-0.60.60.5-0.50.4
Extensor digitorum longus weight3.714.420.74.5-4.2-4.1-3.9-3.64.1-3.6-3.43.4-2.9
Bone: elastic displacement0.00.00.2-0.30.20.10.10.0-0.40.10.0-0.1-0.1
Bone: elastic work0.50.70.80.7-0.8-0.8-0.8-0.90.7-0.8-0.80.8-0.9
Bone: endosteal estimation0.10.20.40.5-0.4-0.4-0.4-0.40.6-0.4-0.40.4-0.3
Bone: endosteal perimeter0.30.50.8-0.80.90.90.80.7-0.50.70.7-0.60.6
Epididymis fat weight0.30.70.9-0.90.80.80.70.8-1.00.80.8-0.80.7
Delta time in closed arm before/after self-admin0.50.51.31.2-1.1-0.9-0.8-0.50.4-0.4-0.30.2-0.1
Delta time in open arm before/after self-admin1.61.61.91.1-1.2-1.2-1.4-1.21.2-1.3-1.31.3-1.4
Diff in mean of infusions in LGA sessions2.12.32.6-1.61.61.61.61.4-1.61.51.5-1.51.4
Delay discount exponential model param2.12.22.7-1.71.51.51.51.6-1.61.51.4-1.41.3
Extinction: sum of active levers before priming1.51.51.9-1.11.11.21.21.2-1.21.31.3-1.31.4
Active lever presses in extinction session 62.02.02.6-1.61.51.51.61.2-1.51.41.3-1.31.1
Bone: final force1.32.13.01.5-1.4-1.4-1.4-1.41.7-1.4-1.41.4-1.3
Bone: final moment1.01.72.41.3-1.2-1.3-1.2-1.31.5-1.3-1.31.3-1.2
Food consumed during 24 hour testing period0.50.61.11.0-0.9-0.9-0.8-0.80.8-0.7-0.70.6-0.5
Glucose1.72.63.01.7-1.7-1.7-1.7-1.61.4-1.6-1.61.5-1.5
Heart weight0.10.20.7-0.40.20.30.20.4-0.80.40.4-0.50.3
Delay discount hyperbolic model param3.03.23.7-1.91.81.81.81.8-1.91.81.7-1.71.6
Intermittent access intake day 1-15 change6.76.67.1-2.62.52.52.62.7-2.62.62.5-2.62.4
Intermittent access intake escalation6.66.57.3-2.42.42.42.52.7-2.72.62.6-2.72.5
Intermittent access intake escalation 27.67.58.7-2.72.52.62.72.9-2.92.82.7-2.92.6
Intermitt. access day 1 inactive lever presses0.20.20.3-0.20.20.30.30.3-0.50.50.5-0.50.6
Intermitt. access day 15 inactive lever presses0.70.70.8-0.80.80.80.90.8-0.80.90.9-0.90.9
Intermitt. access escalation Index0.30.30.40.4-0.3-0.4-0.5-0.50.6-0.6-0.60.7-0.6
Intermittent access day 1 total infusions0.00.10.20.2-0.1-0.1-0.1-0.50.2-0.2-0.20.3-0.2
Intermittent access day 15 total infusions2.22.52.7-1.51.51.61.61.5-1.61.61.6-1.61.6
Intermittent access terminal intake (last 3 days)1.11.21.4-1.11.11.11.21.0-1.11.11.1-1.11.0
Intermittent access total infusions0.30.30.4-0.50.50.60.60.4-0.50.60.6-0.50.6
Intermittent access day 1 locomotion0.60.60.7-0.70.80.80.80.7-0.80.80.8-0.80.8
Intermittent access day 15 total locomotion4.04.34.6-2.12.12.12.12.0-2.12.12.1-2.02.0
Intermittent access total locomotion1.01.11.3-1.11.21.11.10.9-1.01.01.0-1.01.0
Intermittent access standard deviation2.93.13.4-1.61.61.71.81.8-1.81.81.8-1.81.8
Left kidney weight0.00.00.0-0.20.20.20.20.10.00.10.0-0.0-0.0
Right kidney weight1.33.53.9-2.01.91.91.92.0-1.91.91.8-1.81.7
Cocaine induced anxiety0.20.30.8-0.90.80.70.60.4-0.40.40.3-0.20.1
Post-drug Anxiety0.30.30.8-0.90.80.80.70.5-0.50.40.4-0.30.2
Baseline Anxiety0.40.40.7-0.40.40.50.50.6-0.60.70.7-0.80.8
Tail length3.610.811.4-3.23.33.33.23.4-3.13.43.3-3.33.3
Length with tail1.86.77.8-2.72.82.82.52.6-2.42.62.5-2.42.4
Length without tail0.00.10.2-0.50.40.40.20.1-0.00.10.00.0-0.1
Times rat made contact with spout0.10.10.50.7-0.5-0.5-0.4-0.20.3-0.2-0.10.10.1
Lifetime Intake0.10.10.2-0.30.40.40.40.2-0.30.30.4-0.30.4
Liver weight, left1.93.13.71.9-1.9-1.8-1.8-1.71.8-1.7-1.71.6-1.5
Liver weight, right1.42.33.11.5-1.5-1.5-1.4-1.41.7-1.5-1.51.5-1.4
Locomotor activity2.43.85.4-2.32.32.22.11.9-1.71.81.8-1.61.6
Locomotor testing distance1.32.23.3-1.81.71.61.51.4-1.51.41.3-1.21.1
Locomotor testing rearing0.00.10.20.10.10.10.20.3-0.20.30.3-0.40.4
Locomotion in novel chamber0.10.10.3-0.20.20.20.20.5-0.50.40.4-0.50.4
Locomotion in novel chamber post-restriction1.41.62.1-1.01.11.21.31.5-1.11.31.4-1.41.4
Fecal boli incidents, locomotor time 11.41.62.11.5-1.3-1.3-1.2-1.21.4-1.2-1.21.2-1.0
Change in fecal boli incidents, locomotor task0.10.10.3-0.30.40.30.20.6-0.20.30.3-0.30.3
Time >=10cm from walls, locomotor time 11.51.52.30.8-1.0-1.1-1.2-1.21.2-1.3-1.41.4-1.5
Bouts of movement, locomotor time 10.50.50.9-0.40.70.70.60.9-0.40.80.9-0.81.0
Total resting periods, locomotor time 10.60.60.9-0.60.80.80.70.9-0.50.80.9-0.80.9
Rest time, locomotor task time 10.80.91.5-0.81.01.00.91.2-0.50.90.9-0.91.0
Distance moved, locomotor task time 11.51.72.50.9-1.1-1.2-1.1-1.61.1-1.4-1.41.4-1.6
Vertical activity count, locomotor time 10.60.60.90.8-1.0-0.9-0.8-1.00.3-0.7-0.70.6-0.7
Time >=10cm from walls, locomotor time 21.71.82.41.6-1.5-1.4-1.4-1.31.4-1.3-1.21.2-1.1
Bouts of movement, locomotor time 20.30.40.8-0.90.80.80.70.4-0.50.50.4-0.30.2
Total resting periods, locomotor time 20.30.30.8-0.90.80.70.60.3-0.50.40.4-0.30.2
Rest time, locomotor task time 20.50.50.8-0.90.90.80.80.7-0.60.70.6-0.60.5
Distance moved, locomotor task time 20.60.70.91.0-1.0-0.9-0.8-0.90.8-0.8-0.80.7-0.7
Vertical activity count, locomotor time 20.50.51.11.0-1.0-0.9-0.7-0.60.7-0.6-0.60.5-0.4
Light reinforcement 15.910.713.3-3.63.63.53.53.1-3.23.23.1-2.92.8
Light reinforcement 21.72.33.5-1.91.71.71.51.3-1.71.41.4-1.31.2
Bone: marrow area0.10.20.40.5-0.4-0.4-0.4-0.40.6-0.4-0.40.4-0.3
Bone: maximum diameter0.51.01.6-1.31.31.21.11.0-0.80.90.9-0.80.7
Bone: maximum force1.22.02.81.5-1.4-1.4-1.4-1.31.7-1.4-1.41.4-1.2
Bone: maximum moment1.01.72.21.4-1.3-1.3-1.3-1.31.5-1.3-1.31.3-1.2
Mean time between licks in bursts4.46.26.5-2.42.42.52.52.5-2.62.52.5-2.52.5
Mean num. licks in bursts0.00.00.10.1-0.1-0.2-0.2-0.20.1-0.2-0.30.3-0.3
Cd content in liver0.40.40.50.6-0.6-0.6-0.6-0.70.7-0.7-0.70.7-0.6
Co content in liver0.80.91.1-0.80.91.01.01.0-0.81.01.0-1.01.0
Cu content in liver0.10.20.50.2-0.1-0.2-0.2-0.40.7-0.4-0.50.5-0.5
Fe content in liver0.30.40.7-0.40.50.60.60.8-0.30.60.7-0.70.8
K content in liver0.10.10.2-0.30.40.40.30.20.40.10.10.10.1
Mg content in liver0.00.10.2-0.10.20.10.1-0.00.5-0.2-0.20.3-0.2
Mn content in liver0.91.02.1-1.41.41.31.31.0-0.40.80.8-0.60.6
Na content in liver0.60.61.80.6-0.5-0.5-0.5-0.71.4-0.8-0.80.9-0.7
Rb content in liver0.50.60.90.5-0.5-0.6-0.6-0.81.0-0.9-0.91.0-1.0
Se content in liver0.70.81.1-0.71.01.01.10.9-0.40.90.9-0.81.0
Sr content in liver0.10.10.20.10.00.10.10.3-0.30.30.4-0.40.5
Zn content in liver2.02.23.0-1.11.11.21.31.5-1.71.61.6-1.71.7
Bone: minimum diameter0.00.00.1-0.10.20.20.20.20.30.10.2-0.10.2
Time in familiar zone, hab. session 12.52.42.6-1.41.41.51.51.5-1.61.61.6-1.61.6
Time in novel zone, hab. session 11.51.41.71.0-1.0-1.1-1.1-1.21.2-1.3-1.31.3-1.3
Total zone transitions, hab. session 10.81.12.0-1.41.41.31.21.0-0.80.90.8-0.70.6
Total locomotion distance, hab. session 11.01.52.8-1.61.71.51.41.2-0.61.00.9-0.70.7
Locomotion velocity, hab. session 11.62.33.9-1.92.01.91.71.5-0.91.31.2-1.11.1
Time in familiar zone, hab. session 26.76.98.5-2.52.52.52.62.6-2.92.72.7-2.72.6
Time in novel zone, hab. session 25.45.46.22.3-2.2-2.3-2.3-2.32.5-2.4-2.42.4-2.3
Total zone transitions, hab. session 20.40.51.2-0.0-0.0-0.2-0.3-0.60.8-0.8-0.91.0-1.1
Total locomotion distance, hab. session 20.81.02.1-1.51.41.31.20.9-0.80.80.7-0.60.5
Locomotion velocity, hab. session 20.70.92.1-1.51.41.31.10.8-0.70.70.6-0.40.3
Novel to familiar place preference ratio5.35.56.32.0-2.1-2.2-2.3-2.42.4-2.4-2.52.5-2.5
Novelty place preference3.43.44.11.6-1.6-1.7-1.8-1.91.9-1.9-2.02.0-2.0
Time in novel zone, NPP test3.53.64.21.7-1.7-1.8-1.8-1.92.0-2.0-2.02.0-2.0
Total zone transitions, NPP test0.10.20.5-0.30.20.0-0.1-0.30.3-0.4-0.50.6-0.7
Total locomotion distance, NPP test0.10.10.2-0.30.30.10.0-0.20.4-0.3-0.30.4-0.5
Locomotion velocity, NPP test0.10.10.3-0.50.50.40.20.00.1-0.1-0.20.3-0.3
Intraocular pressure0.10.10.20.3-0.3-0.2-0.2-0.0-0.50.20.2-0.30.3
Delta distance traveled before/after self-admin2.12.32.6-1.51.61.61.61.5-1.41.51.5-1.51.5
Delta ambulatory time before/after self-admin2.32.52.8-1.61.71.71.71.6-1.41.61.6-1.51.5
Parametrial fat weight0.50.91.1-0.80.90.90.91.0-1.01.01.0-1.01.0
Pavlov. Cond. lever latency0.10.10.30.4-0.5-0.5-0.4-0.3-0.4-0.2-0.10.0-0.1
Pavlov. Cond. magazine entry latency4.66.06.5-2.42.52.52.52.5-2.12.52.5-2.42.4
Pavlov. Cond. change in total contacts0.50.50.7-0.60.80.80.80.8-0.20.70.7-0.60.8
Pavlov. Cond. index score1.11.42.0-1.21.41.41.41.3-0.61.11.1-1.01.1
Pavlov. Cond. latency score1.01.32.0-1.21.41.41.31.2-0.51.01.0-0.91.0
Pavlov. Cond. lever contacts0.20.20.6-0.60.70.70.60.50.20.30.3-0.10.2
Pavlov. Cond. magazine entry number1.51.92.21.3-1.5-1.5-1.5-1.41.1-1.4-1.41.3-1.4
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.10.10.20.20.3-0.50.40.4-0.50.5
Pavlov. Cond. lever-magazine prob. diff.1.62.02.7-1.51.61.61.61.5-0.91.41.4-1.31.3
Pavlov. Cond. response bias2.22.63.0-1.61.71.71.71.7-1.21.61.6-1.61.6
Pavlov. Cond. lever latency0.50.70.80.8-0.8-0.8-0.8-0.80.9-0.9-0.90.9-0.9
Pavlov. Cond. magazine entry latency0.60.70.8-0.70.80.80.80.9-0.70.80.9-0.80.9
Pavlov. Cond. change in total contacts0.40.50.8-0.70.60.70.70.7-0.90.80.8-0.80.7
Pavlov. Cond. index score0.70.91.0-0.90.90.90.91.0-1.01.01.0-1.01.0
Pavlov. Cond. latency score0.60.70.8-0.80.80.80.80.8-0.80.90.9-0.90.8
Pavlov. Cond. lever contacts0.60.81.0-0.70.70.80.80.9-1.00.91.0-1.01.0
Pavlov. Cond. magazine entry number0.91.11.21.0-1.0-1.0-1.1-1.10.9-1.1-1.11.0-1.1
Pavlov. Cond. intertrial magazine entries0.20.20.60.7-0.7-0.6-0.5-0.40.4-0.4-0.30.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.70.91.0-0.90.90.90.91.0-0.91.01.0-1.01.0
Pavlov. Cond. response bias1.62.22.6-1.31.31.41.41.5-1.61.61.6-1.61.6
Time in closed arm before self-admin1.01.11.80.6-0.7-0.8-0.9-1.11.1-1.1-1.21.2-1.3
Time in closed arm after self-admin0.00.00.1-0.10.00.00.10.2-0.20.10.1-0.20.1
Time in open arm before self-admin1.01.01.4-0.81.01.01.01.0-0.91.11.1-1.11.2
Time in open arm after self-admin0.91.01.31.0-1.0-1.0-1.1-1.00.9-1.0-0.90.9-0.9
Bone: periosteal estimation0.30.61.00.7-0.6-0.6-0.6-0.71.0-0.8-0.80.8-0.8
Bone: periosteal perimeter0.00.10.2-0.40.40.30.30.20.10.10.10.00.0
Bone: post-yield work0.20.20.70.8-0.6-0.5-0.4-0.30.9-0.3-0.30.3-0.0
Progressive ratio test 1 active lever presses0.00.00.10.3-0.1-0.00.1-0.10.00.10.2-0.20.3
Progressive ratio test 1 breakpoint0.00.00.10.4-0.1-0.10.0-0.10.10.10.1-0.10.3
Progressive ratio test 1 inactive lever presses0.10.10.1-0.20.30.30.30.1-0.20.30.3-0.20.3
Progressive ratio test 2 active lever presses0.20.20.3-0.30.30.30.40.3-0.50.50.5-0.50.5
Progressive ratio test 2 breakpoint0.20.20.3-0.40.40.40.40.3-0.50.50.5-0.50.4
Progressive ratio test 2 inactive lever presses0.00.00.1-0.30.20.20.1-0.0-0.10.10.1-0.0-0.0
Incentive Sensitization - Responses0.10.10.2-0.20.10.10.10.2-0.40.20.2-0.30.2
Incentive Sensitization - Breakpoint0.10.10.2-0.30.20.20.20.3-0.50.30.3-0.40.3
Sum of active levers in priming session hrs 5-60.00.00.0-0.0-0.0-0.0-0.1-0.20.1-0.1-0.10.1-0.1
Progressive ratio0.00.00.10.3-0.2-0.2-0.1-0.10.3-0.1-0.10.1-0.1
Food seeking constrained by brief footshock0.50.71.0-0.91.01.00.81.0-0.40.80.7-0.70.7
Seeking ratio, punishment vs. effort0.20.30.5-0.70.70.60.50.5-0.40.40.4-0.40.4
Retroperitoneal fat weight0.20.50.70.8-0.8-0.8-0.8-0.70.7-0.7-0.70.6-0.6
Reaction time number correct0.30.41.21.1-0.9-0.8-0.7-0.40.5-0.3-0.20.10.0
Reaction time mean minus median0.60.91.1-0.80.80.90.81.0-0.91.01.0-1.01.0
Reaction time mean minus median AUC0.00.00.1-0.10.10.1-0.00.00.3-0.0-0.10.1-0.1
Reaction time num false alarms0.10.10.30.5-0.4-0.3-0.1-0.10.1-0.00.1-0.10.3
Reaction time num false alarms AUC0.10.10.40.6-0.5-0.4-0.2-0.10.1-0.00.1-0.10.3
Reaction time trials correct on left0.30.41.21.1-0.9-0.8-0.7-0.40.5-0.3-0.20.10.0
Reaction time trials on left0.30.41.31.1-0.9-0.8-0.7-0.40.5-0.4-0.30.2-0.0
Reaction time mean0.10.10.10.2-0.3-0.3-0.3-0.20.3-0.3-0.30.3-0.3
Reaction time mean AUC0.10.20.20.3-0.4-0.4-0.4-0.40.4-0.4-0.50.4-0.5
Median of all reaction times0.40.60.70.7-0.7-0.8-0.7-0.80.8-0.8-0.80.8-0.9
Reaction time omissions0.10.10.2-0.50.30.30.20.2-0.50.20.1-0.20.0
Reaction time false alarm rate0.00.00.00.2-0.1-0.1-0.0-0.20.1-0.1-0.00.10.0
Reaction time premature initiation rate0.91.21.9-1.01.01.01.11.0-1.41.11.2-1.21.1
Reaction time premature initiations0.71.01.6-0.50.60.70.80.9-1.21.11.2-1.21.3
Std. dev. reaction times0.10.10.2-0.30.30.30.30.4-0.40.40.4-0.40.4
Reaction time trials completed0.30.41.31.1-0.9-0.8-0.7-0.40.5-0.4-0.30.2-0.0
Reaction time trials AUC0.20.31.21.1-0.9-0.8-0.7-0.30.4-0.3-0.20.00.1
Run reversals in cocaine runway, females0.50.50.6-0.70.80.80.80.8-0.50.70.7-0.70.7
Run reversals in cocaine runway, males1.41.41.9-1.41.31.21.21.2-1.21.11.0-1.00.9
Latency to leave start box in cocaine runway0.10.10.6-0.80.50.30.30.0-0.40.1-0.10.1-0.3
Latency to leave start box in cocaine runway, F0.91.02.30.2-0.5-0.7-0.9-1.10.8-1.1-1.21.3-1.5
Latency to leave start box in cocaine runway, M3.33.23.8-1.51.51.61.81.8-1.91.91.9-2.01.9
Std. dev. time between licks in bursts0.60.80.9-0.90.90.90.90.9-0.80.90.9-0.80.8
Total sessions with >9 infusions0.00.10.10.1-0.1-0.1-0.1-0.30.3-0.2-0.20.3-0.3
Short access day 1 total inactive lever presses0.10.10.2-0.40.40.40.40.1-0.30.30.3-0.30.3
Short access day 10 total inactive lever presses0.00.00.00.1-0.1-0.0-0.1-0.10.0-0.0-0.0-0.00.0
Short access day 1 total infusions0.10.10.4-0.60.60.50.50.2-0.20.30.2-0.10.1
Short access day 10 total infusions0.20.20.4-0.20.30.40.50.3-0.40.50.6-0.50.6
Short access total infusions0.00.00.0-0.00.10.00.1-0.00.1-0.0-0.00.1-0.1
Short access day 1 locomotion0.80.91.3-1.11.11.11.00.9-0.90.90.8-0.80.7
Short access day 10 total locomotion3.94.44.6-2.02.02.12.12.1-2.12.12.1-2.12.1
Short access total locomotion0.80.81.0-1.01.01.01.00.9-0.80.90.9-0.80.8
One hour access (0.3 mA shock)0.10.10.20.3-0.3-0.3-0.3-0.50.3-0.3-0.20.2-0.2
Compulsive drug intake1.71.72.01.2-1.2-1.2-1.4-1.31.4-1.4-1.31.4-1.3
One hour access (shock baseline)0.30.30.6-0.30.40.50.50.4-0.60.60.7-0.70.8
Social response proportion0.50.51.0-1.00.90.80.70.7-0.70.60.5-0.50.4
Social responses6.17.99.7-3.13.13.02.92.8-2.72.72.7-2.62.4
Social time0.81.01.30.8-0.9-1.0-1.0-1.00.9-1.1-1.11.1-1.1
Soleus weight9.026.429.95.5-5.4-5.3-5.2-5.15.2-5.1-5.04.9-4.7
Bone: stiffness2.33.75.42.1-1.9-1.9-1.8-1.82.3-1.9-1.81.9-1.6
Tibialis anterior weight0.82.94.12.0-1.8-1.7-1.7-1.62.0-1.6-1.61.6-1.3
Time to tail flick, vehicle, before self-admin0.30.30.7-0.80.80.70.70.2-0.40.40.4-0.30.3
Time to tail flick, vehicle, after self-admin0.30.30.5-0.30.30.40.40.7-0.60.60.6-0.70.7
Time to tail flick, test, before self-admin0.10.10.3-0.50.50.40.3-0.0-0.20.10.1-0.0-0.0
Time to tail flick, test, after self-admin0.30.30.4-0.70.60.60.50.6-0.50.50.4-0.40.3
Delta time to tail flick, vehicle, before/after SA0.20.20.40.7-0.7-0.6-0.5-0.00.2-0.2-0.20.0-0.0
Delta time to tail flick, test, before/after SA0.40.30.7-0.40.40.40.40.8-0.60.60.6-0.70.6
Tibia length0.92.62.7-1.51.61.61.71.6-1.61.61.6-1.61.6
Ambulatory time before self-admin0.90.91.20.7-0.9-0.9-1.0-0.90.8-1.0-1.01.0-1.1
Ambulatory time after self-admin0.20.20.3-0.60.50.50.40.5-0.40.40.3-0.40.2
Bone: tissue strength2.22.12.31.4-1.4-1.4-1.5-1.51.5-1.5-1.51.5-1.5
Total heroin consumption1.92.22.7-1.61.61.61.51.4-1.51.51.4-1.41.3
Bone: trabecular number0.30.51.4-1.21.00.90.80.6-0.60.50.4-0.30.2
Bone: trabecular spacing0.20.31.11.0-0.8-0.6-0.5-0.10.2-0.00.1-0.20.4
Bone: trabecular thickness0.91.13.0-0.1-0.2-0.4-0.6-1.11.0-1.2-1.31.5-1.7
Bone: trabecular tissue density1.11.62.51.6-1.4-1.4-1.3-1.11.4-1.2-1.11.1-0.9
Water consumed over 24 hours0.70.81.10.9-0.8-0.8-0.8-0.91.0-0.9-0.90.9-0.9
Number of responses in last shaping day0.10.10.2-0.40.40.40.30.2-0.40.30.3-0.30.3