Hub : Genes

Spmap2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Spmap2 0.46 0.19 9.2e-11 0.35 0.36 0.36 0.36 3.4e-09 2.0e-09 1.8e-09 2.1e-09
2 BLA gene expression Spmap2 0.15 0.09 2.4e-10 0.16 0.2 0.18 0.19 7.8e-09 1.3e-10 6.8e-10 3.0e-10
3 IL gene expression Spmap2 0.52 0.19 6.7e-12 0.21 0.22 0.2 0.21 9.3e-06 6.5e-06 1.3e-05 8.9e-06
4 pVTA gene expression Spmap2 0.08 0.05 1.1e-09 0.11 0.11 0.11 0.11 2.3e-09 2.0e-09 2.3e-09 3.1e-09
5 LHb gene expression Spmap2 0.3 0.16 3.1e-07 0.25 0.25 0.24 0.25 1.3e-06 1.5e-06 1.8e-06 1.4e-06
6 PL intron excision ratio chr7_10804299_10808984 0.02 0.02 1.3e-03 0.03 0.03 0.03 0.03 5.9e-04 6.6e-04 8.7e-04 7.2e-04
7 IC gene expression Spmap2 0.11 0.07 3.7e-05 0.06 0.07 0.06 0.06 1.6e-03 4.5e-04 1.4e-03 1.7e-03
8 PL gene expression Spmap2 0.3 0.13 0.0e+00 0.43 0.45 0.44 0.45 1.5e-51 2.5e-54 7.3e-52 3.7e-54
9 PL intron excision ratio chr7_10804821_10808984 0.03 0.02 6.3e-04 0.02 0.02 0.02 0.02 4.1e-03 9.5e-04 1.5e-03 1.3e-03
10 PL intron excision ratio chr7_10768106_10777472 0.07 0.04 9.6e-11 0.1 0.1 0.1 0.1 5.4e-11 2.6e-11 1.2e-10 5.4e-11
11 NAcc gene expression Spmap2 0.34 0.17 0.0e+00 0.36 0.38 0.38 0.38 1.3e-56 8.4e-61 2.2e-61 8.2e-62
12 Brain gene expression Spmap2 0.22 0.12 0.0e+00 0.2 0.2 0.2 0.2 4.9e-18 8.9e-19 2.6e-18 2.9e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.50.91.80.1-0.7-0.7-0.81.0-1.0-0.9-1.11.1-1.2-0.9-1.3
Area under the delay curve1.52.32.91.7-1.5-1.5-1.51.3-1.6-1.5-1.51.5-1.4-1.7-1.3
BMI with tail6.321.924.04.9-4.8-4.8-4.84.7-4.6-4.7-4.64.6-4.6-4.5-4.4
BMI without tail1.05.26.92.6-2.4-2.4-2.42.2-2.2-2.3-2.22.2-2.1-2.2-2.0
Body weight0.94.14.52.1-2.1-2.1-2.12.1-2.0-2.1-2.02.0-2.0-2.0-1.9
Weight adjusted by age0.10.40.80.9-0.7-0.7-0.70.7-0.6-0.6-0.50.5-0.5-0.5-0.4
Bone surface0.20.31.0-0.8-0.1-0.1-0.10.5-0.5-0.4-0.60.6-0.7-0.4-1.0
Bone volume0.20.51.3-0.6-0.3-0.3-0.30.7-0.7-0.6-0.80.8-0.9-0.6-1.2
Breakpoint value in progressive ratio session2.64.64.9-2.22.22.22.2-2.12.12.22.2-2.22.12.22.1
Number of licking bursts0.00.00.10.4-0.0-0.0-0.0-0.10.10.10.2-0.20.20.10.4
Context. condit. distance diff. score0.00.10.30.5-0.2-0.2-0.20.1-0.1-0.1-0.10.1-0.1-0.50.1
Locomotion velocity, session 10.20.20.8-0.90.50.50.5-0.30.30.40.3-0.30.20.40.1
Locomotion distance, session 10.10.20.7-0.80.60.50.5-0.30.30.30.2-0.10.1-0.10.1
Locomotion velocity, session 23.94.76.9-2.62.42.42.4-2.22.22.22.0-2.01.91.81.8
Locomotion distance, session 20.81.13.4-1.81.21.21.2-0.90.91.00.8-0.80.70.90.4
Locomotion velocity, session 38.09.29.6-2.83.13.13.1-3.13.13.13.0-3.03.12.83.0
Locomotion distance, session 30.10.10.10.00.20.20.2-0.30.30.20.3-0.30.30.20.4
Stereotopy head waving bouts, day 35.97.07.7-2.82.82.82.8-2.72.72.72.6-2.62.62.42.5
Stereotopy head waving duration, day 36.88.59.1-3.03.03.03.0-2.92.92.92.9-2.92.82.72.8
Locomotion velocity, session 71.31.42.3-0.61.21.21.2-1.31.31.21.2-1.21.30.61.5
Locomotion distance, session 70.00.10.50.7-0.2-0.2-0.20.0-0.0-0.1-0.00.00.1-0.30.3
Stereotopy head waving bouts, day 70.00.00.0-0.20.00.00.00.1-0.1-0.1-0.10.2-0.2-0.2-0.2
Stereotopy head waving duration, day 70.20.20.6-0.80.50.50.5-0.40.40.40.3-0.30.20.30.1
Locomotion velocity, session 80.70.81.2-1.11.11.11.1-1.01.00.90.8-0.80.80.40.8
Locomotion distance, session 80.30.40.6-0.80.70.70.7-0.60.60.60.5-0.50.50.30.5
Degree of sensitization distance0.30.30.60.7-0.5-0.6-0.60.5-0.5-0.5-0.50.5-0.5-0.8-0.4
Degree of sensitization stereotypy2.02.22.51.3-1.5-1.5-1.51.5-1.5-1.5-1.61.6-1.6-1.4-1.6
Conditioned locomotion0.80.92.11.4-1.1-1.0-1.00.8-0.8-0.9-0.80.8-0.7-0.9-0.6
Cocaine response after cond. corrected3.65.48.12.9-2.5-2.5-2.52.3-2.3-2.3-2.22.2-2.1-2.1-1.9
Cocaine response after cond. not corrected3.75.48.42.9-2.5-2.5-2.52.3-2.3-2.3-2.22.1-2.1-2.1-1.9
Cocaine response before conditioning0.70.80.9-0.81.01.01.0-1.01.00.90.9-0.90.90.70.9
Saline control response0.10.10.30.5-0.4-0.4-0.40.3-0.3-0.3-0.30.3-0.3-0.2-0.2
Bone: connectivity density0.71.11.70.4-0.9-0.9-0.91.1-1.1-1.0-1.11.1-1.2-1.1-1.3
Bone: cortical apparent density1.32.12.31.2-1.5-1.5-1.51.5-1.5-1.5-1.41.4-1.5-1.2-1.5
Bone: cortical area0.50.81.20.8-0.8-0.8-0.80.8-0.9-0.9-1.01.0-1.0-1.1-0.9
Bone: cortical porosity0.00.00.1-0.40.20.20.2-0.10.10.10.1-0.10.10.10.0
Bone: cortical porosity0.00.10.1-0.2-0.1-0.1-0.10.2-0.2-0.2-0.30.3-0.3-0.3-0.4
Bone: cortical thickness1.32.22.61.3-1.4-1.5-1.51.5-1.5-1.5-1.51.6-1.6-1.6-1.5
Bone: cortical thickness0.00.10.10.20.10.10.1-0.20.20.20.3-0.30.30.30.3
Bone: cortical tissue density1.01.51.81.0-1.3-1.3-1.31.3-1.3-1.3-1.21.2-1.3-1.0-1.4
Condit. Reinf. active minus inactive responses5.36.06.2-2.52.52.52.5-2.52.42.52.4-2.42.42.42.3
Condit. Reinf. active-inactive response ratio2.42.53.4-1.61.51.51.5-1.51.51.61.6-1.61.61.81.5
Condit. Reinf. active responses3.74.76.2-2.52.32.32.3-2.22.12.22.1-2.12.02.01.9
Condit. Reinf. inactive responses0.50.61.5-1.21.00.90.9-0.80.80.80.7-0.60.60.60.5
Incentive salience index mean2.73.44.2-2.02.02.02.0-1.91.91.91.8-1.81.81.71.7
Condit. Reinf. lever presses0.00.10.2-0.50.10.10.10.1-0.1-0.0-0.20.2-0.3-0.3-0.3
Condit. Reinf. active minus inactive responses1.72.63.2-1.41.51.51.5-1.61.61.61.7-1.71.71.81.6
Condit. Reinf. active-inactive response ratio0.00.00.20.1-0.2-0.2-0.20.1-0.1-0.10.0-0.00.00.4-0.1
Condit. Reinf. active responses1.92.83.0-1.51.61.61.6-1.71.71.71.7-1.71.71.71.7
Condit. Reinf. inactive responses1.42.02.6-1.11.41.41.4-1.51.51.51.5-1.51.51.11.6
Condit. Reinf. lever presses1.72.53.0-1.41.51.51.5-1.61.61.61.6-1.61.61.71.6
Condit. Reinf. lever reinforcers received1.52.12.4-1.11.41.41.4-1.51.51.51.5-1.51.51.51.5
Conditioned reinforcement - actives0.41.72.1-1.11.21.21.2-1.51.31.31.3-1.31.41.41.3
Conditioned reinforcement - inactives0.00.00.00.2-0.1-0.1-0.1-0.1-0.0-0.0-0.0-0.00.00.00.1
Conditioned locomotion5.98.811.1-3.23.03.03.0-3.32.83.02.9-2.92.92.92.7
Patch foraging indifference point 0 sec0.20.50.80.5-0.7-0.7-0.70.9-0.7-0.7-0.70.8-0.8-0.7-0.8
Patch foraging indifference point AUC0.40.91.3-1.00.91.00.9-1.00.91.01.0-1.00.91.10.9
Delay disc. indifference point, 0s delay9.310.511.62.7-3.1-3.2-3.23.3-3.2-3.3-3.43.4-3.4-3.3-3.4
Delay disc. indifference point, 16s delay0.10.20.30.4-0.4-0.4-0.40.1-0.5-0.4-0.40.4-0.4-0.5-0.4
Delay disc. indifference point, 2s delay6.26.97.82.6-2.6-2.6-2.62.4-2.6-2.6-2.72.7-2.6-2.8-2.5
Delay disc. indifference point, 24s delay0.50.71.11.1-0.9-0.9-0.90.6-1.0-0.8-0.80.8-0.8-0.9-0.7
Delay disc. indifference point, 4s delay1.01.11.51.1-1.0-1.0-1.00.8-1.2-1.0-1.11.1-1.0-1.2-0.9
Delay disc. indifference point, 8s delay0.71.22.11.4-1.2-1.1-1.11.0-1.0-1.1-1.01.0-1.0-1.3-0.8
Indifference point function ln k0.00.10.30.5-0.4-0.4-0.40.3-0.3-0.3-0.30.3-0.3-0.4-0.2
Indifference point function log k0.00.10.30.5-0.4-0.4-0.40.3-0.3-0.3-0.30.3-0.3-0.4-0.2
Patch foraging total patch changes 0 sec0.10.30.40.5-0.6-0.6-0.60.7-0.5-0.6-0.60.6-0.6-0.6-0.6
Patch foraging total patch changes 12 sec0.40.60.80.8-0.8-0.8-0.80.9-0.7-0.8-0.70.7-0.7-0.7-0.7
Patch foraging total patch changes 18 sec0.40.91.3-1.11.01.01.0-0.91.01.00.9-0.90.91.10.8
Patch foraging total patch changes 24 sec0.00.00.1-0.30.10.10.1-0.1-0.00.00.0-0.0-0.00.2-0.1
Patch foraging total patch changes 6 sec0.00.00.2-0.40.10.10.10.20.20.10.1-0.1-0.00.3-0.2
Patch foraging time to switch 0 sec0.51.93.00.8-1.2-1.2-1.21.3-1.4-1.3-1.51.5-1.5-1.7-1.5
Patch foraging water rate 0 sec0.10.20.70.40.20.20.2-0.50.50.40.5-0.50.60.50.8
Patch foraging water rate 12 sec0.20.92.61.6-1.1-1.1-1.10.7-0.9-0.9-0.80.7-0.6-0.7-0.5
Patch foraging water rate 18 sec0.20.51.30.30.40.40.4-0.70.70.60.9-0.91.00.81.2
Patch foraging water rate 24 sec0.10.21.31.2-0.5-0.4-0.40.0-0.1-0.20.0-0.00.2-0.10.4
Patch foraging water rate 6 sec0.50.81.5-0.10.70.70.7-1.00.80.91.0-1.01.10.91.2
Seeking ratio, delayed vs. immediate footshock3.44.96.7-2.32.32.32.3-2.62.12.22.1-2.12.22.02.1
Distance traveled before self-admin0.20.51.00.5-0.7-0.7-0.71.0-0.7-0.7-0.70.7-0.8-0.6-0.8
Distance traveled after self-admin0.00.00.1-0.1-0.1-0.1-0.10.2-0.1-0.1-0.00.1-0.1-0.0-0.1
Extensor digitorum longus weight3.212.719.74.4-3.7-3.7-3.73.4-3.4-3.5-3.43.4-3.2-3.8-2.8
Bone: elastic displacement0.00.00.1-0.30.00.00.00.1-0.10.00.0-0.0-0.00.4-0.2
Bone: elastic work0.60.81.00.7-0.9-0.9-0.91.0-1.0-0.9-0.90.9-0.9-0.7-1.0
Bone: endosteal estimation0.10.20.30.5-0.4-0.4-0.40.3-0.3-0.4-0.40.4-0.3-0.5-0.3
Bone: endosteal perimeter0.30.60.8-0.90.90.90.9-0.80.80.80.7-0.70.70.60.7
Epididymis fat weight0.00.10.10.10.10.10.1-0.00.30.20.3-0.30.30.40.4
Delta time in closed arm before/after self-admin0.30.31.21.1-0.7-0.7-0.70.7-0.3-0.5-0.30.3-0.3-0.3-0.2
Delta time in open arm before/after self-admin0.60.70.80.7-0.8-0.8-0.80.9-0.9-0.8-0.80.8-0.8-0.7-0.8
Diff in mean of infusions in LGA sessions1.22.22.5-1.61.51.51.5-1.41.41.51.5-1.51.41.51.3
Delay discount exponential model param1.31.82.4-1.61.41.41.4-1.11.41.31.3-1.31.21.61.1
Extinction: sum of active levers before priming0.81.21.4-0.91.11.11.1-1.21.01.11.1-1.11.11.01.1
Active lever presses in extinction session 61.41.42.3-1.51.21.21.2-1.01.01.21.2-1.21.11.30.9
Bone: final force1.32.13.01.5-1.4-1.4-1.41.4-1.4-1.4-1.51.5-1.4-1.7-1.3
Bone: final moment1.11.82.41.3-1.3-1.3-1.31.3-1.3-1.3-1.41.4-1.3-1.6-1.2
Food consumed during 24 hour testing period0.30.71.01.0-0.9-0.9-0.90.8-0.8-0.8-0.80.8-0.7-0.8-0.6
Glucose3.04.85.32.3-2.3-2.3-2.32.2-2.2-2.2-2.22.2-2.1-2.0-2.1
Heart weight0.61.01.6-0.80.90.90.9-0.91.01.01.1-1.11.11.31.0
Delay discount hyperbolic model param2.63.44.1-2.01.91.91.9-1.61.91.81.9-1.81.82.01.6
Intermittent access intake day 1-15 change1.26.68.4-2.52.52.62.6-2.02.92.62.7-2.72.62.72.5
Intermittent access intake escalation1.15.97.5-2.32.42.42.4-1.92.72.42.6-2.52.52.52.4
Intermittent access intake escalation 22.94.96.1-2.22.22.22.2-1.72.52.22.3-2.32.22.32.1
Intermitt. access day 1 inactive lever presses0.00.40.8-0.10.50.50.5-0.60.80.60.7-0.70.80.60.9
Intermitt. access day 15 inactive lever presses0.10.50.7-0.80.80.70.7-0.70.70.70.7-0.70.70.70.6
Intermitt. access escalation Index0.41.31.60.8-1.1-1.1-1.11.1-1.3-1.2-1.21.2-1.2-1.2-1.3
Intermittent access day 1 total infusions0.10.41.2-0.30.60.60.6-1.10.40.60.6-0.60.70.60.8
Intermittent access day 15 total infusions1.74.14.4-1.92.02.02.0-2.02.12.02.1-2.12.12.02.0
Intermittent access terminal intake (last 3 days)1.72.93.4-1.61.71.71.7-1.81.81.71.7-1.71.71.61.7
Intermittent access total infusions1.21.41.8-1.11.21.21.2-1.41.21.21.2-1.21.21.21.2
Intermittent access day 1 locomotion1.52.83.5-1.31.61.61.6-1.91.61.71.7-1.71.81.71.8
Intermittent access day 15 total locomotion1.76.57.4-2.32.52.52.5-2.72.62.62.6-2.62.62.52.6
Intermittent access total locomotion3.13.74.8-1.61.91.91.9-2.21.91.91.9-1.92.01.92.0
Intermittent access standard deviation1.47.47.8-2.82.72.82.8-2.62.82.72.7-2.72.72.82.5
Left kidney weight0.00.31.00.30.40.40.4-0.70.70.50.6-0.60.70.21.0
Right kidney weight0.43.04.0-1.21.61.61.6-1.61.91.71.9-1.91.91.72.0
Cocaine induced anxiety0.41.02.2-1.51.11.11.1-1.00.91.00.8-0.80.80.90.6
Post-drug Anxiety0.91.02.2-1.51.11.11.1-1.00.91.00.8-0.80.80.90.6
Baseline Anxiety0.00.10.1-0.20.20.20.2-0.20.30.30.3-0.30.30.30.3
Tail length2.714.515.0-3.63.83.83.8-3.83.93.93.9-3.83.83.73.8
Length with tail2.29.610.2-2.93.13.13.1-3.13.23.13.1-3.13.12.93.1
Length without tail0.00.00.00.2-0.1-0.1-0.1-0.00.0-0.0-0.00.00.0-0.10.1
Times rat made contact with spout0.10.10.40.6-0.3-0.3-0.30.2-0.2-0.3-0.20.2-0.1-0.30.0
Lifetime Intake0.70.81.1-0.80.90.90.9-1.00.90.90.9-0.90.90.90.9
Liver weight, left0.91.51.71.3-1.3-1.3-1.31.2-1.3-1.2-1.21.2-1.2-1.0-1.1
Liver weight, right0.40.71.41.2-0.9-0.9-0.90.9-0.7-0.8-0.70.7-0.7-0.8-0.5
Locomotor activity2.23.55.1-2.32.12.02.0-1.91.91.91.7-1.71.71.51.6
Locomotor testing distance0.81.93.4-1.81.51.51.5-1.31.41.41.3-1.31.21.31.1
Locomotor testing rearing0.00.10.20.00.20.20.2-0.40.30.30.3-0.30.40.20.4
Locomotion in novel chamber0.70.91.2-0.90.90.90.9-0.81.11.01.0-1.01.01.10.9
Locomotion in novel chamber post-restriction0.92.63.2-1.31.61.61.6-1.71.81.61.6-1.61.71.61.7
Fecal boli incidents, locomotor time 10.61.62.21.4-1.3-1.3-1.31.3-1.2-1.3-1.31.3-1.2-1.5-1.1
Change in fecal boli incidents, locomotor task0.20.20.4-0.40.40.40.4-0.50.70.40.4-0.40.40.30.4
Time >=10cm from walls, locomotor time 11.21.52.40.7-1.1-1.1-1.11.6-1.2-1.2-1.21.2-1.3-1.1-1.4
Bouts of movement, locomotor time 10.71.01.5-0.61.01.01.0-1.11.11.01.0-1.01.10.61.2
Total resting periods, locomotor time 10.91.01.4-0.71.01.01.0-1.11.11.01.0-1.01.10.71.2
Rest time, locomotor task time 10.50.81.5-0.70.90.90.9-0.81.20.90.9-0.90.90.51.0
Distance moved, locomotor task time 10.82.23.10.9-1.4-1.4-1.41.6-1.7-1.5-1.51.5-1.6-1.2-1.7
Vertical activity count, locomotor time 10.10.81.20.8-1.0-1.0-1.01.0-1.1-0.9-0.90.9-0.9-0.5-1.0
Time >=10cm from walls, locomotor time 20.61.72.41.5-1.4-1.4-1.41.4-1.3-1.3-1.21.2-1.2-1.4-1.1
Bouts of movement, locomotor time 20.10.20.7-0.80.60.60.6-0.50.30.50.4-0.40.40.50.3
Total resting periods, locomotor time 20.00.20.7-0.80.50.50.5-0.40.20.40.3-0.30.30.40.2
Rest time, locomotor task time 20.40.61.0-1.00.90.90.9-0.70.80.80.8-0.70.70.70.7
Distance moved, locomotor task time 20.50.60.90.9-0.8-0.8-0.80.7-0.8-0.8-0.80.7-0.7-0.8-0.7
Vertical activity count, locomotor time 20.20.41.01.0-0.7-0.7-0.70.6-0.6-0.6-0.50.5-0.5-0.6-0.4
Light reinforcement 12.29.913.1-3.63.33.33.3-3.42.93.23.0-3.02.93.02.7
Light reinforcement 21.02.23.4-1.81.61.61.6-1.71.31.51.3-1.31.31.51.2
Bone: marrow area0.10.10.30.5-0.4-0.4-0.40.3-0.3-0.3-0.30.3-0.3-0.5-0.2
Bone: maximum diameter0.71.31.9-1.41.31.21.2-1.21.11.21.1-1.11.01.01.0
Bone: maximum force1.02.02.71.6-1.4-1.4-1.41.3-1.4-1.4-1.41.4-1.4-1.7-1.2
Bone: maximum moment0.91.82.31.4-1.3-1.3-1.31.3-1.3-1.3-1.31.3-1.3-1.5-1.2
Mean time between licks in bursts1.16.56.8-2.52.62.62.6-2.62.62.62.6-2.62.52.62.5
Mean num. licks in bursts0.00.10.10.1-0.2-0.2-0.20.3-0.3-0.3-0.30.3-0.3-0.2-0.3
Cd content in liver0.00.00.2-0.40.20.20.2-0.2-0.00.10.1-0.10.10.3-0.0
Co content in liver1.41.71.9-1.31.31.31.3-1.31.31.31.3-1.31.31.41.2
Cu content in liver0.10.20.3-0.60.50.50.5-0.50.40.40.3-0.30.30.10.3
Fe content in liver0.60.81.2-0.40.90.90.9-0.91.00.90.9-0.90.90.51.1
K content in liver0.00.00.1-0.20.20.20.2-0.20.20.10.0-0.00.0-0.20.1
Mg content in liver0.10.10.3-0.60.40.40.4-0.30.40.40.3-0.30.30.40.2
Mn content in liver1.11.22.2-1.51.31.31.3-1.11.11.11.0-1.00.90.80.9
Na content in liver0.70.81.60.7-0.8-0.8-0.80.8-0.8-0.9-1.01.0-1.0-1.3-0.9
Rb content in liver0.00.10.2-0.3-0.0-0.1-0.10.2-0.2-0.2-0.30.3-0.3-0.2-0.4
Se content in liver0.70.91.2-0.61.01.01.0-1.11.01.00.9-0.91.00.51.1
Sr content in liver0.00.00.00.2-0.0-0.0-0.0-0.10.00.00.0-0.00.10.00.1
Zn content in liver3.23.85.9-1.81.81.81.8-1.81.91.92.0-2.02.02.41.8
Bone: minimum diameter0.00.00.10.10.20.10.2-0.20.20.10.1-0.10.1-0.20.2
Time in familiar zone, hab. session 12.12.42.6-1.51.51.51.5-1.51.51.51.6-1.61.61.61.5
Time in novel zone, hab. session 11.31.51.71.0-1.2-1.2-1.21.2-1.2-1.2-1.31.3-1.3-1.2-1.3
Total zone transitions, hab. session 10.60.81.8-1.41.11.01.0-0.90.90.90.8-0.70.70.70.6
Total locomotion distance, hab. session 10.91.32.5-1.61.41.31.3-1.21.21.21.0-1.00.90.70.9
Locomotion velocity, hab. session 11.52.23.4-1.81.71.71.7-1.51.51.51.3-1.31.31.01.2
Time in familiar zone, hab. session 26.47.28.7-2.72.62.72.7-2.62.62.72.8-2.82.73.02.6
Time in novel zone, hab. session 25.25.66.42.3-2.3-2.4-2.42.3-2.3-2.4-2.42.4-2.4-2.5-2.3
Total zone transitions, hab. session 20.40.51.1-0.0-0.5-0.5-0.50.7-0.7-0.7-0.90.9-0.9-0.9-1.0
Total locomotion distance, hab. session 20.81.02.4-1.61.21.11.1-0.90.91.00.8-0.80.70.80.6
Locomotion velocity, hab. session 20.60.92.5-1.61.11.11.1-0.80.80.90.7-0.70.60.70.5
Novel to familiar place preference ratio4.45.76.22.1-2.3-2.4-2.42.4-2.4-2.4-2.52.5-2.5-2.4-2.5
Novelty place preference2.83.64.01.6-1.8-1.8-1.81.9-1.9-1.9-2.02.0-2.0-1.9-2.0
Time in novel zone, NPP test3.13.84.11.7-1.9-1.9-1.91.9-1.9-2.0-2.02.0-2.0-2.0-2.0
Total zone transitions, NPP test0.10.20.5-0.3-0.2-0.2-0.20.4-0.4-0.4-0.50.5-0.6-0.4-0.7
Total locomotion distance, NPP test0.00.10.1-0.30.0-0.0-0.00.1-0.1-0.1-0.30.3-0.3-0.4-0.4
Locomotion velocity, NPP test0.00.00.3-0.50.20.20.2-0.00.00.1-0.10.1-0.1-0.1-0.2
Intraocular pressure0.00.00.20.3-0.2-0.1-0.1-0.1-0.1-0.00.1-0.10.20.40.1
Delta distance traveled before/after self-admin0.60.70.9-0.70.80.80.8-0.90.80.80.8-0.80.90.70.9
Delta ambulatory time before/after self-admin0.40.70.8-0.70.80.80.8-0.90.80.80.8-0.80.80.60.9
Parametrial fat weight0.00.00.0-0.1-0.0-0.0-0.00.0-0.1-0.1-0.10.1-0.1-0.1-0.2
Pavlov. Cond. lever latency0.10.10.20.4-0.4-0.4-0.40.3-0.4-0.3-0.10.1-0.20.3-0.3
Pavlov. Cond. magazine entry latency4.66.06.4-2.32.52.52.5-2.52.52.52.4-2.42.42.12.5
Pavlov. Cond. change in total contacts0.40.50.7-0.40.70.70.7-0.80.80.70.6-0.60.70.10.9
Pavlov. Cond. index score1.11.41.7-1.11.31.31.3-1.31.31.21.1-1.11.10.61.2
Pavlov. Cond. latency score0.91.21.6-1.11.31.21.2-1.21.21.11.0-1.01.00.51.1
Pavlov. Cond. lever contacts0.10.10.2-0.30.40.40.4-0.30.40.30.1-0.10.2-0.30.3
Pavlov. Cond. magazine entry number1.72.12.41.3-1.5-1.5-1.51.5-1.6-1.5-1.51.5-1.5-1.1-1.6
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.20.30.30.3-0.30.30.30.4-0.40.40.50.4
Pavlov. Cond. lever-magazine prob. diff.1.31.61.9-1.21.41.41.4-1.41.41.31.2-1.21.20.81.3
Pavlov. Cond. response bias1.82.22.6-1.31.51.51.5-1.61.61.51.5-1.51.51.11.6
Pavlov. Cond. lever latency0.50.70.90.8-0.8-0.8-0.80.9-0.9-0.9-0.90.9-0.9-0.9-0.9
Pavlov. Cond. magazine entry latency0.50.70.8-0.70.80.80.8-0.90.80.80.8-0.80.80.70.9
Pavlov. Cond. change in total contacts0.20.50.7-0.60.60.60.6-0.60.70.70.7-0.70.70.90.7
Pavlov. Cond. index score0.50.80.8-0.70.80.80.8-0.90.90.90.9-0.90.90.90.9
Pavlov. Cond. latency score0.40.70.8-0.70.80.80.8-0.80.80.80.8-0.80.80.90.8
Pavlov. Cond. lever contacts0.40.60.8-0.60.70.80.7-0.80.80.80.8-0.80.80.90.8
Pavlov. Cond. magazine entry number0.81.11.20.9-1.0-1.0-1.01.1-1.1-1.0-1.01.0-1.1-0.9-1.1
Pavlov. Cond. intertrial magazine entries0.10.20.60.8-0.6-0.5-0.50.4-0.4-0.5-0.40.4-0.4-0.5-0.3
Pavlov. Cond. lever-magazine prob. diff.0.50.80.9-0.80.90.90.9-0.90.90.90.9-0.90.90.90.9
Pavlov. Cond. response bias1.52.02.3-1.21.41.41.4-1.41.41.41.5-1.51.51.51.5
Time in closed arm before self-admin0.40.71.00.4-0.7-0.7-0.71.0-0.8-0.8-0.80.8-0.9-0.9-1.0
Time in closed arm after self-admin0.20.20.4-0.30.40.40.4-0.00.60.40.5-0.50.50.50.4
Time in open arm before self-admin0.10.20.7-0.30.40.40.4-0.80.40.40.3-0.30.40.20.4
Time in open arm after self-admin1.11.21.31.1-1.1-1.1-1.10.9-1.1-1.1-1.11.1-1.1-1.0-1.0
Bone: periosteal estimation0.20.40.70.5-0.5-0.6-0.60.6-0.6-0.6-0.70.7-0.7-0.8-0.6
Bone: periosteal perimeter0.00.10.2-0.40.40.40.4-0.30.30.30.2-0.20.20.10.2
Bone: post-yield work0.20.31.11.0-0.6-0.6-0.60.4-0.4-0.5-0.50.5-0.4-0.9-0.2
Progressive ratio test 1 active lever presses0.30.51.3-0.10.60.60.6-1.10.60.70.7-0.70.90.61.0
Progressive ratio test 1 breakpoint0.30.51.3-0.10.60.60.6-1.10.60.70.7-0.70.80.61.0
Progressive ratio test 1 inactive lever presses0.30.71.0-0.60.80.80.8-1.00.80.80.9-0.90.90.80.9
Progressive ratio test 2 active lever presses0.40.50.9-0.30.60.60.6-1.00.70.70.7-0.80.80.70.9
Progressive ratio test 2 breakpoint0.50.61.1-0.30.60.70.7-1.00.70.80.8-0.80.90.81.0
Progressive ratio test 2 inactive lever presses0.00.10.2-0.40.40.40.4-0.30.40.40.4-0.40.30.40.3
Incentive Sensitization - Responses0.00.00.10.3-0.1-0.1-0.1-0.00.1-0.00.0-0.00.10.10.1
Incentive Sensitization - Breakpoint0.00.00.00.1-0.00.00.0-0.10.20.10.1-0.10.20.20.2
Sum of active levers in priming session hrs 5-60.00.00.10.1-0.2-0.2-0.20.0-0.3-0.2-0.20.2-0.2-0.2-0.2
Progressive ratio0.00.10.40.5-0.4-0.4-0.40.6-0.2-0.3-0.30.3-0.3-0.4-0.2
Food seeking constrained by brief footshock0.50.60.9-0.80.90.80.9-0.91.00.80.7-0.70.70.60.8
Seeking ratio, punishment vs. effort0.20.40.7-0.80.70.70.7-0.90.60.60.5-0.50.60.60.5
Retroperitoneal fat weight0.21.01.81.3-1.1-1.1-1.11.3-0.8-1.0-0.80.8-0.8-0.9-0.7
Reaction time number correct0.10.21.11.0-0.6-0.5-0.50.4-0.3-0.4-0.20.2-0.1-0.30.0
Reaction time mean minus median0.10.81.1-0.70.80.90.9-0.90.90.90.9-0.90.91.00.9
Reaction time mean minus median AUC0.00.00.0-0.00.00.00.0-0.0-0.0-0.0-0.10.1-0.1-0.0-0.1
Reaction time num false alarms0.00.10.60.7-0.3-0.3-0.3-0.1-0.1-0.2-0.10.10.0-0.30.2
Reaction time num false alarms AUC0.00.10.60.8-0.3-0.2-0.2-0.1-0.1-0.1-0.10.00.1-0.30.3
Reaction time trials correct on left0.10.21.11.0-0.6-0.5-0.50.4-0.3-0.4-0.20.2-0.1-0.30.0
Reaction time trials on left0.10.21.11.0-0.6-0.6-0.60.5-0.3-0.4-0.30.2-0.2-0.3-0.0
Reaction time mean0.10.10.20.3-0.4-0.4-0.40.4-0.4-0.4-0.40.4-0.4-0.3-0.4
Reaction time mean AUC0.10.20.30.3-0.5-0.5-0.50.5-0.5-0.5-0.50.5-0.5-0.3-0.6
Median of all reaction times0.40.70.80.7-0.8-0.8-0.80.8-0.9-0.8-0.80.9-0.9-0.8-0.9
Reaction time omissions0.00.00.2-0.40.10.10.10.1-0.00.00.00.0-0.10.3-0.2
Reaction time false alarm rate0.00.00.10.3-0.2-0.2-0.2-0.1-0.2-0.2-0.20.2-0.1-0.4-0.0
Reaction time premature initiation rate0.71.21.7-1.01.01.01.0-1.21.01.11.1-1.11.11.31.0
Reaction time premature initiations0.31.01.6-0.60.80.80.8-1.11.01.01.1-1.11.11.31.1
Std. dev. reaction times0.00.10.2-0.30.30.30.3-0.30.30.30.4-0.40.30.50.3
Reaction time trials completed0.10.21.11.0-0.6-0.6-0.60.5-0.3-0.4-0.30.2-0.2-0.3-0.0
Reaction time trials AUC0.10.21.11.1-0.6-0.5-0.50.4-0.3-0.4-0.20.2-0.1-0.30.1
Run reversals in cocaine runway, females0.50.60.8-0.90.80.80.8-0.60.80.80.8-0.70.70.70.7
Run reversals in cocaine runway, males1.51.62.5-1.61.31.31.3-1.11.31.31.2-1.21.21.41.0
Latency to leave start box in cocaine runway0.10.10.4-0.60.00.00.00.4-0.2-0.1-0.10.1-0.30.2-0.5
Latency to leave start box in cocaine runway, F0.81.02.20.1-0.8-0.9-0.91.2-1.1-1.0-1.11.1-1.2-0.6-1.5
Latency to leave start box in cocaine runway, M1.91.82.1-1.21.31.31.3-1.11.41.31.5-1.41.41.31.3
Std. dev. time between licks in bursts0.50.91.0-0.91.01.01.0-1.01.00.90.9-0.90.90.80.9
Total sessions with >9 infusions0.50.60.8-0.40.70.70.7-0.80.80.80.8-0.80.80.70.9
Short access day 1 total inactive lever presses0.30.70.8-0.70.80.80.8-0.90.70.80.8-0.80.80.80.8
Short access day 10 total inactive lever presses0.00.00.00.20.00.00.0-0.00.20.10.1-0.10.10.00.2
Short access day 1 total infusions0.30.70.8-0.80.80.80.8-0.90.80.80.8-0.80.80.80.8
Short access day 10 total infusions0.30.51.0-0.20.60.60.6-1.00.60.70.7-0.70.80.50.9
Short access total infusions0.40.50.6-0.60.70.70.7-0.80.70.70.7-0.70.70.70.8
Short access day 1 locomotion1.22.02.1-1.31.41.41.4-1.51.31.41.4-1.41.41.41.4
Short access day 10 total locomotion2.28.910.1-2.52.92.92.9-2.83.23.03.1-3.13.13.03.1
Short access total locomotion2.13.23.4-1.61.71.81.8-1.81.81.81.8-1.81.81.81.8
One hour access (0.3 mA shock)0.00.00.10.10.10.10.1-0.40.10.10.1-0.10.20.10.2
Compulsive drug intake1.21.72.21.0-1.2-1.2-1.21.0-1.4-1.3-1.41.4-1.4-1.5-1.4
One hour access (shock baseline)0.51.31.8-0.71.01.01.0-1.31.11.11.2-1.21.21.11.3
Social response proportion0.50.61.2-1.10.80.80.8-0.60.80.80.7-0.70.70.80.6
Social responses6.38.310.0-3.23.03.03.0-2.82.92.92.8-2.82.72.82.6
Social time0.50.81.00.7-0.9-0.9-0.91.0-0.9-0.9-0.90.9-0.9-0.8-1.0
Soleus weight8.324.527.45.2-5.1-5.1-5.14.9-4.9-5.0-4.94.9-4.8-5.0-4.5
Bone: stiffness1.83.35.12.1-1.8-1.8-1.81.7-1.7-1.8-1.81.8-1.8-2.3-1.5
Tibialis anterior weight0.72.53.92.0-1.6-1.6-1.61.4-1.4-1.6-1.51.5-1.4-1.9-1.2
Time to tail flick, vehicle, before self-admin0.10.10.5-0.40.30.30.3-0.70.00.30.2-0.20.30.20.3
Time to tail flick, vehicle, after self-admin0.30.71.0-0.50.70.70.7-0.61.00.80.9-0.90.90.90.9
Time to tail flick, test, before self-admin0.10.20.4-0.60.50.50.5-0.60.30.40.3-0.30.30.40.2
Time to tail flick, test, after self-admin0.10.20.4-0.40.40.40.40.00.60.40.4-0.40.40.40.3
Delta time to tail flick, vehicle, before/after SA0.10.10.50.5-0.3-0.3-0.30.70.2-0.20.0-0.0-0.1-0.0-0.0
Delta time to tail flick, test, before/after SA0.10.10.30.10.10.10.10.30.50.20.4-0.40.30.30.4
Tibia length0.92.42.5-1.51.61.61.6-1.61.61.61.6-1.61.61.51.5
Ambulatory time before self-admin0.20.51.00.5-0.7-0.7-0.71.0-0.7-0.7-0.70.7-0.8-0.6-0.9
Ambulatory time after self-admin0.00.00.20.0-0.2-0.2-0.20.4-0.2-0.2-0.20.2-0.2-0.1-0.3
Bone: tissue strength2.42.52.61.4-1.6-1.6-1.61.6-1.6-1.6-1.61.6-1.6-1.6-1.6
Total heroin consumption1.41.62.2-1.51.31.31.3-1.41.21.31.2-1.21.21.31.0
Bone: trabecular number0.10.20.9-1.00.60.60.6-0.40.40.40.3-0.30.20.30.1
Bone: trabecular spacing0.10.11.11.0-0.4-0.4-0.40.1-0.1-0.2-0.10.00.0-0.10.2
Bone: trabecular thickness0.81.22.5-0.1-0.8-0.8-0.81.1-1.1-1.0-1.21.2-1.4-1.1-1.6
Bone: trabecular tissue density0.81.32.21.5-1.2-1.2-1.21.1-1.1-1.1-1.11.1-1.0-1.3-0.9
Water consumed over 24 hours0.50.91.41.0-0.9-0.9-0.90.9-0.9-0.9-1.00.9-0.9-1.2-0.8
Number of responses in last shaping day1.82.42.6-1.31.51.51.5-1.61.61.61.6-1.61.61.61.6