Hub : Genes

Spmap2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Spmap2 0.46 0.19 9.2e-11 0.35 0.36 0.36 0.36 3.4e-09 2.0e-09 1.8e-09 2.1e-09
2 BLA gene expression Spmap2 0.15 0.09 2.4e-10 0.16 0.2 0.18 0.19 7.8e-09 1.3e-10 6.8e-10 2.9e-10
3 IL gene expression Spmap2 0.52 0.19 6.7e-12 0.21 0.22 0.2 0.21 9.3e-06 6.5e-06 1.3e-05 8.6e-06
4 pVTA gene expression Spmap2 0.08 0.05 1.1e-09 0.11 0.11 0.11 0.11 2.3e-09 2.0e-09 2.3e-09 3.2e-09
5 LHb gene expression Spmap2 0.3 0.16 3.1e-07 0.25 0.25 0.24 0.25 1.3e-06 1.5e-06 1.8e-06 1.3e-06
6 PL intron excision ratio chr7_10804299_10808984 0.02 0.02 1.3e-03 0.03 0.03 0.03 0.03 5.9e-04 6.6e-04 8.7e-04 7.8e-04
7 IC gene expression Spmap2 0.11 0.07 3.7e-05 0.06 0.07 0.06 0.06 1.6e-03 4.5e-04 1.4e-03 1.6e-03
8 PL gene expression Spmap2 0.3 0.13 0.0e+00 0.43 0.45 0.44 0.45 1.5e-51 2.5e-54 7.3e-52 3.7e-54
9 PL intron excision ratio chr7_10804821_10808984 0.03 0.02 6.3e-04 0.02 0.02 0.02 0.02 4.1e-03 9.5e-04 1.4e-03 1.3e-03
10 PL intron excision ratio chr7_10768106_10777472 0.07 0.04 9.6e-11 0.1 0.1 0.1 0.1 5.4e-11 2.6e-11 1.3e-10 5.6e-11
11 NAcc gene expression Spmap2 0.34 0.17 0.0e+00 0.36 0.38 0.38 0.38 1.3e-56 8.4e-61 2.2e-61 7.8e-62
12 Brain gene expression Spmap2 0.22 0.12 0.0e+00 0.2 0.2 0.2 0.2 4.9e-18 8.9e-19 2.6e-18 3.0e-18

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.50.91.8-0.1-0.7-0.7-0.8-1.01.0-0.9-1.11.1-1.2-0.9-1.3
Area under the delay curve2.02.32.9-1.7-1.5-1.5-1.5-1.31.6-1.5-1.51.5-1.4-1.7-1.3
BMI with tail6.321.924.0-4.9-4.8-4.8-4.8-4.74.6-4.7-4.64.6-4.6-4.5-4.4
BMI without tail1.75.26.9-2.6-2.4-2.4-2.4-2.22.2-2.3-2.22.2-2.1-2.2-2.0
Body weight0.94.14.5-2.1-2.1-2.1-2.1-2.12.0-2.1-2.02.0-2.0-2.0-1.9
Weight adjusted by age0.30.40.8-0.9-0.7-0.7-0.7-0.70.6-0.6-0.50.5-0.5-0.5-0.4
Bone surface0.20.31.00.8-0.1-0.1-0.1-0.50.5-0.4-0.60.6-0.7-0.4-1.0
Bone volume0.30.51.30.6-0.3-0.3-0.3-0.70.7-0.6-0.80.8-0.9-0.6-1.2
Breakpoint value in progressive ratio session3.94.64.92.22.22.22.22.1-2.12.22.2-2.22.12.22.1
Number of licking bursts0.00.00.1-0.4-0.0-0.0-0.00.1-0.10.10.2-0.20.20.10.4
Context. condit. distance diff. score0.00.10.3-0.5-0.2-0.2-0.2-0.10.1-0.1-0.10.1-0.1-0.50.1
Locomotion velocity, session 10.20.20.80.90.50.50.50.3-0.30.40.3-0.30.20.40.1
Locomotion distance, session 10.10.20.70.80.60.50.50.3-0.30.30.2-0.10.1-0.10.1
Locomotion velocity, session 24.04.76.92.62.42.42.42.2-2.22.22.0-2.01.91.81.8
Locomotion distance, session 20.81.13.41.81.21.21.20.9-0.91.00.8-0.80.70.90.4
Locomotion velocity, session 38.09.29.62.83.13.13.13.1-3.13.13.0-3.03.12.83.0
Locomotion distance, session 30.10.10.1-0.00.20.20.20.3-0.30.20.3-0.30.30.20.4
Stereotopy head waving bouts, day 36.07.07.72.82.82.82.82.7-2.72.72.6-2.62.62.42.5
Stereotopy head waving duration, day 37.18.59.13.03.03.03.02.9-2.92.92.9-2.92.82.72.8
Locomotion velocity, session 71.31.42.30.61.21.21.21.3-1.31.21.2-1.21.30.61.5
Locomotion distance, session 70.00.10.5-0.7-0.2-0.2-0.2-0.00.0-0.1-0.00.00.1-0.30.3
Stereotopy head waving bouts, day 70.00.00.00.20.00.00.0-0.10.1-0.1-0.10.2-0.2-0.2-0.2
Stereotopy head waving duration, day 70.20.20.60.80.50.50.50.4-0.40.40.3-0.30.20.30.1
Locomotion velocity, session 80.70.81.21.11.11.11.11.0-1.00.90.8-0.80.80.40.8
Locomotion distance, session 80.30.40.60.80.70.70.70.6-0.60.60.5-0.50.50.30.5
Degree of sensitization distance0.30.30.6-0.7-0.5-0.6-0.6-0.50.5-0.5-0.50.5-0.5-0.8-0.4
Degree of sensitization stereotypy2.12.22.5-1.3-1.5-1.5-1.5-1.51.5-1.5-1.61.6-1.6-1.4-1.6
Conditioned locomotion0.80.92.1-1.4-1.1-1.0-1.0-0.80.8-0.9-0.80.8-0.7-0.9-0.6
Cocaine response after cond. corrected4.55.48.1-2.9-2.5-2.5-2.5-2.32.3-2.3-2.22.2-2.1-2.1-1.9
Cocaine response after cond. not corrected4.65.48.4-2.9-2.5-2.5-2.5-2.32.3-2.3-2.22.1-2.1-2.1-1.9
Cocaine response before conditioning0.70.80.90.81.01.01.01.0-1.00.90.9-0.90.90.70.9
Saline control response0.10.10.3-0.5-0.4-0.4-0.4-0.30.3-0.3-0.30.3-0.3-0.2-0.2
Bone: connectivity density0.71.11.7-0.4-0.9-0.9-0.9-1.11.1-1.0-1.11.1-1.2-1.1-1.3
Bone: cortical apparent density1.52.12.3-1.2-1.5-1.5-1.5-1.51.5-1.5-1.41.4-1.5-1.2-1.5
Bone: cortical area0.50.81.2-0.8-0.8-0.8-0.8-0.80.9-0.9-1.01.0-1.0-1.1-0.9
Bone: cortical porosity0.00.00.10.40.20.20.20.1-0.10.10.1-0.10.10.10.0
Bone: cortical porosity0.00.10.10.2-0.1-0.1-0.1-0.20.2-0.2-0.30.3-0.3-0.3-0.4
Bone: cortical thickness1.42.22.6-1.3-1.4-1.5-1.5-1.51.5-1.5-1.51.6-1.6-1.6-1.5
Bone: cortical thickness0.00.10.1-0.20.10.10.10.2-0.20.20.3-0.30.30.30.3
Bone: cortical tissue density1.11.51.8-1.0-1.3-1.3-1.3-1.31.3-1.3-1.21.2-1.3-1.0-1.4
Condit. Reinf. active minus inactive responses5.46.06.22.52.52.52.52.5-2.42.52.4-2.42.42.42.3
Condit. Reinf. active-inactive response ratio2.42.53.41.61.51.51.51.5-1.51.61.6-1.61.61.81.5
Condit. Reinf. active responses3.84.76.22.52.32.32.32.2-2.12.22.1-2.12.02.01.9
Condit. Reinf. inactive responses0.50.61.51.21.00.90.90.8-0.80.80.7-0.60.60.60.5
Incentive salience index mean2.83.44.22.02.02.02.01.9-1.91.91.8-1.81.81.71.7
Condit. Reinf. lever presses0.00.10.20.50.10.10.1-0.10.1-0.0-0.20.2-0.3-0.3-0.3
Condit. Reinf. active minus inactive responses2.02.63.21.41.51.51.51.6-1.61.61.7-1.71.71.81.6
Condit. Reinf. active-inactive response ratio0.00.00.2-0.1-0.2-0.2-0.2-0.10.1-0.10.0-0.00.00.4-0.1
Condit. Reinf. active responses2.02.83.01.51.61.61.61.7-1.71.71.7-1.71.71.71.7
Condit. Reinf. inactive responses1.62.02.61.11.41.41.41.5-1.51.51.5-1.51.51.11.6
Condit. Reinf. lever presses1.82.53.01.41.51.51.51.6-1.61.61.6-1.61.61.71.6
Condit. Reinf. lever reinforcers received1.52.12.41.11.41.41.41.5-1.51.51.5-1.51.51.51.5
Conditioned reinforcement - actives1.01.72.11.11.21.21.21.5-1.31.31.3-1.31.41.41.3
Conditioned reinforcement - inactives0.00.00.0-0.2-0.1-0.1-0.10.10.0-0.0-0.0-0.00.00.00.1
Conditioned locomotion6.88.811.13.23.03.03.03.3-2.83.02.9-2.92.92.92.7
Patch foraging indifference point 0 sec0.30.50.8-0.5-0.7-0.7-0.7-0.90.7-0.7-0.70.8-0.8-0.7-0.8
Patch foraging indifference point AUC0.60.91.31.00.91.00.91.0-0.91.01.0-1.00.91.10.9
Delay disc. indifference point, 0s delay9.610.511.6-2.7-3.1-3.2-3.2-3.33.2-3.3-3.43.4-3.4-3.3-3.4
Delay disc. indifference point, 16s delay0.10.20.3-0.4-0.4-0.4-0.4-0.10.5-0.4-0.40.4-0.4-0.5-0.4
Delay disc. indifference point, 2s delay6.26.97.8-2.6-2.6-2.6-2.6-2.42.6-2.6-2.72.7-2.6-2.8-2.5
Delay disc. indifference point, 24s delay0.70.71.1-1.1-0.9-0.9-0.9-0.61.0-0.8-0.80.8-0.8-0.9-0.7
Delay disc. indifference point, 4s delay1.11.11.5-1.1-1.0-1.0-1.0-0.81.2-1.0-1.11.1-1.0-1.2-0.9
Delay disc. indifference point, 8s delay1.01.22.1-1.4-1.2-1.1-1.1-1.01.0-1.1-1.01.0-1.0-1.3-0.8
Indifference point function ln k0.10.10.3-0.5-0.4-0.4-0.4-0.30.3-0.3-0.30.3-0.3-0.4-0.2
Indifference point function log k0.10.10.3-0.5-0.4-0.4-0.4-0.30.3-0.3-0.30.3-0.3-0.4-0.2
Patch foraging total patch changes 0 sec0.20.30.4-0.5-0.6-0.6-0.6-0.70.5-0.6-0.60.6-0.6-0.6-0.6
Patch foraging total patch changes 12 sec0.50.60.8-0.8-0.8-0.8-0.8-0.90.7-0.8-0.70.7-0.7-0.7-0.7
Patch foraging total patch changes 18 sec0.60.91.31.11.01.01.00.9-1.01.00.9-0.90.91.10.8
Patch foraging total patch changes 24 sec0.00.00.10.30.10.10.10.10.00.00.0-0.0-0.00.2-0.1
Patch foraging total patch changes 6 sec0.00.00.20.40.10.10.1-0.2-0.20.10.1-0.1-0.00.3-0.2
Patch foraging time to switch 0 sec0.91.93.0-0.8-1.2-1.2-1.2-1.31.4-1.3-1.51.5-1.5-1.7-1.5
Patch foraging water rate 0 sec0.10.20.7-0.40.20.20.20.5-0.50.40.5-0.50.60.50.8
Patch foraging water rate 12 sec0.40.92.6-1.6-1.1-1.1-1.1-0.70.9-0.9-0.80.7-0.6-0.7-0.5
Patch foraging water rate 18 sec0.40.51.3-0.30.40.40.40.7-0.70.60.9-0.91.00.81.2
Patch foraging water rate 24 sec0.10.21.3-1.2-0.5-0.4-0.4-0.00.1-0.20.0-0.00.2-0.10.4
Patch foraging water rate 6 sec0.50.81.50.10.70.70.71.0-0.80.91.0-1.01.10.91.2
Seeking ratio, delayed vs. immediate footshock4.04.96.72.32.32.32.32.6-2.12.22.1-2.12.22.02.1
Distance traveled before self-admin0.40.51.0-0.5-0.7-0.7-0.7-1.00.7-0.7-0.70.7-0.8-0.6-0.8
Distance traveled after self-admin0.00.00.10.1-0.1-0.1-0.1-0.20.1-0.1-0.00.1-0.1-0.0-0.1
Extensor digitorum longus weight3.212.719.7-4.4-3.7-3.7-3.7-3.43.4-3.5-3.43.4-3.2-3.8-2.8
Bone: elastic displacement0.00.00.10.30.00.00.0-0.10.10.00.0-0.0-0.00.4-0.2
Bone: elastic work0.60.81.0-0.7-0.9-0.9-0.9-1.01.0-0.9-0.90.9-0.9-0.7-1.0
Bone: endosteal estimation0.10.20.3-0.5-0.4-0.4-0.4-0.30.3-0.4-0.40.4-0.3-0.5-0.3
Bone: endosteal perimeter0.30.60.80.90.90.90.90.8-0.80.80.7-0.70.70.60.7
Epididymis fat weight0.00.10.1-0.10.10.10.10.0-0.30.20.3-0.30.30.40.4
Delta time in closed arm before/after self-admin0.30.31.2-1.1-0.7-0.7-0.7-0.70.3-0.5-0.30.3-0.3-0.3-0.2
Delta time in open arm before/after self-admin0.70.70.8-0.7-0.8-0.8-0.8-0.90.9-0.8-0.80.8-0.8-0.7-0.8
Diff in mean of infusions in LGA sessions1.82.22.51.61.51.51.51.4-1.41.51.5-1.51.41.51.3
Delay discount exponential model param1.61.82.41.61.41.41.41.1-1.41.31.3-1.31.21.61.1
Extinction: sum of active levers before priming1.11.21.40.91.11.11.11.2-1.01.11.1-1.11.11.01.1
Active lever presses in extinction session 61.41.42.31.51.21.21.21.0-1.01.21.2-1.21.11.30.9
Bone: final force1.32.13.0-1.5-1.4-1.4-1.4-1.41.4-1.4-1.51.5-1.4-1.7-1.3
Bone: final moment1.11.82.4-1.3-1.3-1.3-1.3-1.31.3-1.3-1.41.4-1.3-1.6-1.2
Food consumed during 24 hour testing period0.50.71.0-1.0-0.9-0.9-0.9-0.80.8-0.8-0.80.8-0.7-0.8-0.6
Glucose3.14.85.3-2.3-2.3-2.3-2.3-2.22.2-2.2-2.22.2-2.1-2.0-2.1
Heart weight0.71.01.60.80.90.90.90.9-1.01.01.1-1.11.11.31.0
Delay discount hyperbolic model param3.03.44.12.01.91.91.91.6-1.91.81.9-1.81.82.01.6
Intermittent access intake day 1-15 change3.26.68.42.52.52.62.62.0-2.92.62.7-2.72.62.72.5
Intermittent access intake escalation2.95.97.52.32.42.42.41.9-2.72.42.6-2.52.52.52.4
Intermittent access intake escalation 24.34.96.12.22.22.22.21.7-2.52.22.3-2.32.22.32.1
Intermitt. access day 1 inactive lever presses0.10.40.80.10.50.50.50.6-0.80.60.7-0.70.80.60.9
Intermitt. access day 15 inactive lever presses0.20.50.70.80.80.70.70.7-0.70.70.7-0.70.70.70.6
Intermitt. access escalation Index0.91.31.6-0.8-1.1-1.1-1.1-1.11.3-1.2-1.21.2-1.2-1.2-1.3
Intermittent access day 1 total infusions0.30.41.20.30.60.60.61.1-0.40.60.6-0.60.70.60.8
Intermittent access day 15 total infusions2.84.14.41.92.02.02.02.0-2.12.02.1-2.12.12.02.0
Intermittent access terminal intake (last 3 days)2.22.93.41.61.71.71.71.8-1.81.71.7-1.71.71.61.7
Intermittent access total infusions1.21.41.81.11.21.21.21.4-1.21.21.2-1.21.21.21.2
Intermittent access day 1 locomotion2.22.83.51.31.61.61.61.9-1.61.71.7-1.71.81.71.8
Intermittent access day 15 total locomotion3.66.57.42.32.52.52.52.7-2.62.62.6-2.62.62.52.6
Intermittent access total locomotion3.13.74.81.61.91.91.92.2-1.91.91.9-1.92.01.92.0
Intermittent access standard deviation3.57.47.82.82.72.82.82.6-2.82.72.7-2.72.72.82.5
Left kidney weight0.10.31.0-0.30.40.40.40.7-0.70.50.6-0.60.70.21.0
Right kidney weight0.73.04.01.21.61.61.61.6-1.91.71.9-1.91.91.72.0
Cocaine induced anxiety0.71.02.21.51.11.11.11.0-0.91.00.8-0.80.80.90.6
Post-drug Anxiety0.91.02.21.51.11.11.11.0-0.91.00.8-0.80.80.90.6
Baseline Anxiety0.10.10.10.20.20.20.20.2-0.30.30.3-0.30.30.30.3
Tail length3.714.515.03.63.83.83.83.8-3.93.93.9-3.83.83.73.8
Length with tail2.29.610.22.93.13.13.13.1-3.23.13.1-3.13.12.93.1
Length without tail0.00.00.0-0.2-0.1-0.1-0.10.0-0.0-0.0-0.00.00.0-0.10.1
Times rat made contact with spout0.10.10.4-0.6-0.3-0.3-0.3-0.20.2-0.3-0.20.2-0.1-0.30.0
Lifetime Intake0.70.81.10.80.90.90.91.0-0.90.90.9-0.90.90.90.9
Liver weight, left0.91.51.7-1.3-1.3-1.3-1.3-1.21.3-1.2-1.21.2-1.2-1.0-1.1
Liver weight, right0.40.71.4-1.2-0.9-0.9-0.9-0.90.7-0.8-0.70.7-0.7-0.8-0.5
Locomotor activity2.23.55.12.32.12.02.01.9-1.91.91.7-1.71.71.51.6
Locomotor testing distance1.11.93.41.81.51.51.51.3-1.41.41.3-1.31.21.31.1
Locomotor testing rearing0.00.10.2-0.00.20.20.20.4-0.30.30.3-0.30.40.20.4
Locomotion in novel chamber0.70.91.20.90.90.90.90.8-1.11.01.0-1.01.01.10.9
Locomotion in novel chamber post-restriction1.62.63.21.31.61.61.61.7-1.81.61.6-1.61.71.61.7
Fecal boli incidents, locomotor time 11.11.62.2-1.4-1.3-1.3-1.3-1.31.2-1.3-1.31.3-1.2-1.5-1.1
Change in fecal boli incidents, locomotor task0.20.20.40.40.40.40.40.5-0.70.40.4-0.40.40.30.4
Time >=10cm from walls, locomotor time 11.41.52.4-0.7-1.1-1.1-1.1-1.61.2-1.2-1.21.2-1.3-1.1-1.4
Bouts of movement, locomotor time 10.81.01.50.61.01.01.01.1-1.11.01.0-1.01.10.61.2
Total resting periods, locomotor time 10.91.01.40.71.01.01.01.1-1.11.01.0-1.01.10.71.2
Rest time, locomotor task time 10.60.81.50.70.90.90.90.8-1.20.90.9-0.90.90.51.0
Distance moved, locomotor task time 11.52.23.1-0.9-1.4-1.4-1.4-1.61.7-1.5-1.51.5-1.6-1.2-1.7
Vertical activity count, locomotor time 10.40.81.2-0.8-1.0-1.0-1.0-1.01.1-0.9-0.90.9-0.9-0.5-1.0
Time >=10cm from walls, locomotor time 21.21.72.4-1.5-1.4-1.4-1.4-1.41.3-1.3-1.21.2-1.2-1.4-1.1
Bouts of movement, locomotor time 20.20.20.70.80.60.60.60.5-0.30.50.4-0.40.40.50.3
Total resting periods, locomotor time 20.10.20.70.80.50.50.50.4-0.20.40.3-0.30.30.40.2
Rest time, locomotor task time 20.50.61.01.00.90.90.90.7-0.80.80.8-0.70.70.70.7
Distance moved, locomotor task time 20.50.60.9-0.9-0.8-0.8-0.8-0.70.8-0.8-0.80.7-0.7-0.8-0.7
Vertical activity count, locomotor time 20.30.41.0-1.0-0.7-0.7-0.7-0.60.6-0.6-0.50.5-0.5-0.6-0.4
Light reinforcement 14.09.913.13.63.33.33.33.4-2.93.23.0-3.02.93.02.7
Light reinforcement 21.42.23.41.81.61.61.61.7-1.31.51.3-1.31.31.51.2
Bone: marrow area0.10.10.3-0.5-0.4-0.4-0.4-0.30.3-0.3-0.30.3-0.3-0.5-0.2
Bone: maximum diameter0.71.31.91.41.31.21.21.2-1.11.21.1-1.11.01.01.0
Bone: maximum force1.12.02.7-1.6-1.4-1.4-1.4-1.31.4-1.4-1.41.4-1.4-1.7-1.2
Bone: maximum moment1.01.82.3-1.4-1.3-1.3-1.3-1.31.3-1.3-1.31.3-1.3-1.5-1.2
Mean time between licks in bursts2.76.56.82.52.62.62.62.6-2.62.62.6-2.62.52.62.5
Mean num. licks in bursts0.00.10.1-0.1-0.2-0.2-0.2-0.30.3-0.3-0.30.3-0.3-0.2-0.3
Cd content in liver0.00.00.20.40.20.20.20.20.00.10.1-0.10.10.3-0.0
Co content in liver1.41.71.91.31.31.31.31.3-1.31.31.3-1.31.31.41.2
Cu content in liver0.10.20.30.60.50.50.50.5-0.40.40.3-0.30.30.10.3
Fe content in liver0.60.81.20.40.90.90.90.9-1.00.90.9-0.90.90.51.1
K content in liver0.00.00.10.20.20.20.20.2-0.20.10.0-0.00.0-0.20.1
Mg content in liver0.10.10.30.60.40.40.40.3-0.40.40.3-0.30.30.40.2
Mn content in liver1.11.22.21.51.31.31.31.1-1.11.11.0-1.00.90.80.9
Na content in liver0.80.81.6-0.7-0.8-0.8-0.8-0.80.8-0.9-1.01.0-1.0-1.3-0.9
Rb content in liver0.00.10.20.3-0.0-0.1-0.1-0.20.2-0.2-0.30.3-0.3-0.2-0.4
Se content in liver0.70.91.20.61.01.01.01.1-1.01.00.9-0.91.00.51.1
Sr content in liver0.00.00.0-0.2-0.0-0.0-0.00.1-0.00.00.0-0.00.10.00.1
Zn content in liver3.43.85.91.81.81.81.81.8-1.91.92.0-2.02.02.41.8
Bone: minimum diameter0.00.00.1-0.10.20.10.20.2-0.20.10.1-0.10.1-0.20.2
Time in familiar zone, hab. session 12.42.42.61.51.51.51.51.5-1.51.51.6-1.61.61.61.5
Time in novel zone, hab. session 11.51.51.7-1.0-1.2-1.2-1.2-1.21.2-1.2-1.31.3-1.3-1.2-1.3
Total zone transitions, hab. session 10.60.81.81.41.11.01.00.9-0.90.90.8-0.70.70.70.6
Total locomotion distance, hab. session 10.91.32.51.61.41.31.31.2-1.21.21.0-1.00.90.70.9
Locomotion velocity, hab. session 11.52.23.41.81.71.71.71.5-1.51.51.3-1.31.31.01.2
Time in familiar zone, hab. session 26.97.28.72.72.62.72.72.6-2.62.72.8-2.82.73.02.6
Time in novel zone, hab. session 25.65.66.4-2.3-2.3-2.4-2.4-2.32.3-2.4-2.42.4-2.4-2.5-2.3
Total zone transitions, hab. session 20.40.51.10.0-0.5-0.5-0.5-0.70.7-0.7-0.90.9-0.9-0.9-1.0
Total locomotion distance, hab. session 20.81.02.41.61.21.11.10.9-0.91.00.8-0.80.70.80.6
Locomotion velocity, hab. session 20.60.92.51.61.11.11.10.8-0.80.90.7-0.70.60.70.5
Novel to familiar place preference ratio5.35.76.2-2.1-2.3-2.4-2.4-2.42.4-2.4-2.52.5-2.5-2.4-2.5
Novelty place preference3.33.64.0-1.6-1.8-1.8-1.8-1.91.9-1.9-2.02.0-2.0-1.9-2.0
Time in novel zone, NPP test3.53.84.1-1.7-1.9-1.9-1.9-1.91.9-2.0-2.02.0-2.0-2.0-2.0
Total zone transitions, NPP test0.10.20.50.3-0.2-0.2-0.2-0.40.4-0.4-0.50.5-0.6-0.4-0.7
Total locomotion distance, NPP test0.00.10.10.30.0-0.0-0.0-0.10.1-0.1-0.30.3-0.3-0.4-0.4
Locomotion velocity, NPP test0.00.00.30.50.20.20.20.0-0.00.1-0.10.1-0.1-0.1-0.2
Intraocular pressure0.00.00.2-0.3-0.2-0.1-0.10.10.1-0.00.1-0.10.20.40.1
Delta distance traveled before/after self-admin0.60.70.90.70.80.80.80.9-0.80.80.8-0.80.90.70.9
Delta ambulatory time before/after self-admin0.50.70.80.70.80.80.80.9-0.80.80.8-0.80.80.60.9
Parametrial fat weight0.00.00.00.1-0.0-0.0-0.0-0.00.1-0.1-0.10.1-0.1-0.1-0.2
Pavlov. Cond. lever latency0.10.10.2-0.4-0.4-0.4-0.4-0.30.4-0.3-0.10.1-0.20.3-0.3
Pavlov. Cond. magazine entry latency4.66.06.42.32.52.52.52.5-2.52.52.4-2.42.42.12.5
Pavlov. Cond. change in total contacts0.40.50.70.40.70.70.70.8-0.80.70.6-0.60.70.10.9
Pavlov. Cond. index score1.11.41.71.11.31.31.31.3-1.31.21.1-1.11.10.61.2
Pavlov. Cond. latency score0.91.21.61.11.31.21.21.2-1.21.11.0-1.01.00.51.1
Pavlov. Cond. lever contacts0.10.10.20.30.40.40.40.3-0.40.30.1-0.10.2-0.30.3
Pavlov. Cond. magazine entry number1.72.12.4-1.3-1.5-1.5-1.5-1.51.6-1.5-1.51.5-1.5-1.1-1.6
Pavlov. Cond. intertrial magazine entries0.10.10.30.20.30.30.30.3-0.30.30.4-0.40.40.50.4
Pavlov. Cond. lever-magazine prob. diff.1.31.61.91.21.41.41.41.4-1.41.31.2-1.21.20.81.3
Pavlov. Cond. response bias1.82.22.61.31.51.51.51.6-1.61.51.5-1.51.51.11.6
Pavlov. Cond. lever latency0.50.70.9-0.8-0.8-0.8-0.8-0.90.9-0.9-0.90.9-0.9-0.9-0.9
Pavlov. Cond. magazine entry latency0.50.70.80.70.80.80.80.9-0.80.80.8-0.80.80.70.9
Pavlov. Cond. change in total contacts0.30.50.70.60.60.60.60.6-0.70.70.7-0.70.70.90.7
Pavlov. Cond. index score0.60.80.80.70.80.80.80.9-0.90.90.9-0.90.90.90.9
Pavlov. Cond. latency score0.50.70.80.70.80.80.80.8-0.80.80.8-0.80.80.90.8
Pavlov. Cond. lever contacts0.50.60.80.60.70.80.70.8-0.80.80.8-0.80.80.90.8
Pavlov. Cond. magazine entry number0.91.11.2-0.9-1.0-1.0-1.0-1.11.1-1.0-1.01.0-1.1-0.9-1.1
Pavlov. Cond. intertrial magazine entries0.20.20.6-0.8-0.6-0.5-0.5-0.40.4-0.5-0.40.4-0.4-0.5-0.3
Pavlov. Cond. lever-magazine prob. diff.0.60.80.90.80.90.90.90.9-0.90.90.9-0.90.90.90.9
Pavlov. Cond. response bias1.52.02.31.21.41.41.41.4-1.41.41.5-1.51.51.51.5
Time in closed arm before self-admin0.50.71.0-0.4-0.7-0.7-0.7-1.00.8-0.8-0.80.8-0.9-0.9-1.0
Time in closed arm after self-admin0.20.20.40.30.40.40.40.0-0.60.40.5-0.50.50.50.4
Time in open arm before self-admin0.20.20.70.30.40.40.40.8-0.40.40.3-0.30.40.20.4
Time in open arm after self-admin1.11.21.3-1.1-1.1-1.1-1.1-0.91.1-1.1-1.11.1-1.1-1.0-1.0
Bone: periosteal estimation0.20.40.7-0.5-0.5-0.6-0.6-0.60.6-0.6-0.70.7-0.7-0.8-0.6
Bone: periosteal perimeter0.00.10.20.40.40.40.40.3-0.30.30.2-0.20.20.10.2
Bone: post-yield work0.20.31.1-1.0-0.6-0.6-0.6-0.40.4-0.5-0.50.5-0.4-0.9-0.2
Progressive ratio test 1 active lever presses0.40.51.30.10.60.60.61.1-0.60.70.7-0.70.90.61.0
Progressive ratio test 1 breakpoint0.40.51.30.10.60.60.61.1-0.60.70.7-0.70.80.61.0
Progressive ratio test 1 inactive lever presses0.50.71.00.60.80.80.81.0-0.80.80.9-0.90.90.80.9
Progressive ratio test 2 active lever presses0.40.50.90.30.60.60.61.0-0.70.70.7-0.80.80.70.9
Progressive ratio test 2 breakpoint0.50.61.10.30.60.70.71.0-0.70.80.8-0.80.90.81.0
Progressive ratio test 2 inactive lever presses0.10.10.20.40.40.40.40.3-0.40.40.4-0.40.30.40.3
Incentive Sensitization - Responses0.00.00.1-0.3-0.1-0.1-0.10.0-0.1-0.00.0-0.00.10.10.1
Incentive Sensitization - Breakpoint0.00.00.0-0.1-0.00.00.00.1-0.20.10.1-0.10.20.20.2
Sum of active levers in priming session hrs 5-60.00.00.1-0.1-0.2-0.2-0.2-0.00.3-0.2-0.20.2-0.2-0.2-0.2
Progressive ratio0.10.10.4-0.5-0.4-0.4-0.4-0.60.2-0.3-0.30.3-0.3-0.4-0.2
Food seeking constrained by brief footshock0.50.60.90.80.90.80.90.9-1.00.80.7-0.70.70.60.8
Seeking ratio, punishment vs. effort0.30.40.70.80.70.70.70.9-0.60.60.5-0.50.60.60.5
Retroperitoneal fat weight0.21.01.8-1.3-1.1-1.1-1.1-1.30.8-1.0-0.80.8-0.8-0.9-0.7
Reaction time number correct0.10.21.1-1.0-0.6-0.5-0.5-0.40.3-0.4-0.20.2-0.1-0.30.0
Reaction time mean minus median0.30.81.10.70.80.90.90.9-0.90.90.9-0.90.91.00.9
Reaction time mean minus median AUC0.00.00.00.00.00.00.00.00.0-0.0-0.10.1-0.1-0.0-0.1
Reaction time num false alarms0.10.10.6-0.7-0.3-0.3-0.30.10.1-0.2-0.10.10.0-0.30.2
Reaction time num false alarms AUC0.10.10.6-0.8-0.3-0.2-0.20.10.1-0.1-0.10.00.1-0.30.3
Reaction time trials correct on left0.10.21.1-1.0-0.6-0.5-0.5-0.40.3-0.4-0.20.2-0.1-0.30.0
Reaction time trials on left0.10.21.1-1.0-0.6-0.6-0.6-0.50.3-0.4-0.30.2-0.2-0.3-0.0
Reaction time mean0.10.10.2-0.3-0.4-0.4-0.4-0.40.4-0.4-0.40.4-0.4-0.3-0.4
Reaction time mean AUC0.10.20.3-0.3-0.5-0.5-0.5-0.50.5-0.5-0.50.5-0.5-0.3-0.6
Median of all reaction times0.50.70.8-0.7-0.8-0.8-0.8-0.80.9-0.8-0.80.9-0.9-0.8-0.9
Reaction time omissions0.00.00.20.40.10.10.1-0.10.00.00.00.0-0.10.3-0.2
Reaction time false alarm rate0.00.00.1-0.3-0.2-0.2-0.20.10.2-0.2-0.20.2-0.1-0.4-0.0
Reaction time premature initiation rate0.81.21.71.01.01.01.01.2-1.01.11.1-1.11.11.31.0
Reaction time premature initiations0.61.01.60.60.80.80.81.1-1.01.01.1-1.11.11.31.1
Std. dev. reaction times0.10.10.20.30.30.30.30.3-0.30.30.4-0.40.30.50.3
Reaction time trials completed0.10.21.1-1.0-0.6-0.6-0.6-0.50.3-0.4-0.30.2-0.2-0.3-0.0
Reaction time trials AUC0.10.21.1-1.1-0.6-0.5-0.5-0.40.3-0.4-0.20.2-0.1-0.30.1
Run reversals in cocaine runway, females0.60.60.80.90.80.80.80.6-0.80.80.8-0.70.70.70.7
Run reversals in cocaine runway, males1.61.62.51.61.31.31.31.1-1.31.31.2-1.21.21.41.0
Latency to leave start box in cocaine runway0.10.10.40.60.00.00.0-0.40.2-0.1-0.10.1-0.30.2-0.5
Latency to leave start box in cocaine runway, F0.91.02.2-0.1-0.8-0.9-0.9-1.21.1-1.0-1.11.1-1.2-0.6-1.5
Latency to leave start box in cocaine runway, M1.91.82.11.21.31.31.31.1-1.41.31.5-1.41.41.31.3
Std. dev. time between licks in bursts0.60.91.00.91.01.01.01.0-1.00.90.9-0.90.90.80.9
Total sessions with >9 infusions0.50.60.80.40.70.70.70.8-0.80.80.8-0.80.80.70.9
Short access day 1 total inactive lever presses0.50.70.80.70.80.80.80.9-0.70.80.8-0.80.80.80.8
Short access day 10 total inactive lever presses0.00.00.0-0.20.00.00.00.0-0.20.10.1-0.10.10.00.2
Short access day 1 total infusions0.50.70.80.80.80.80.80.9-0.80.80.8-0.80.80.80.8
Short access day 10 total infusions0.40.51.00.20.60.60.61.0-0.60.70.7-0.70.80.50.9
Short access total infusions0.40.50.60.60.70.70.70.8-0.70.70.7-0.70.70.70.8
Short access day 1 locomotion1.62.02.11.31.41.41.41.5-1.31.41.4-1.41.41.41.4
Short access day 10 total locomotion4.88.910.12.52.92.92.92.8-3.23.03.1-3.13.13.03.1
Short access total locomotion2.63.23.41.61.71.81.81.8-1.81.81.8-1.81.81.81.8
One hour access (0.3 mA shock)0.00.00.1-0.10.10.10.10.4-0.10.10.1-0.10.20.10.2
Compulsive drug intake1.41.72.2-1.0-1.2-1.2-1.2-1.01.4-1.3-1.41.4-1.4-1.5-1.4
One hour access (shock baseline)0.81.31.80.71.01.01.01.3-1.11.11.2-1.21.21.11.3
Social response proportion0.60.61.21.10.80.80.80.6-0.80.80.7-0.70.70.80.6
Social responses6.48.310.03.23.03.03.02.8-2.92.92.8-2.82.72.82.6
Social time0.60.81.0-0.7-0.9-0.9-0.9-1.00.9-0.9-0.90.9-0.9-0.8-1.0
Soleus weight8.324.527.4-5.2-5.1-5.1-5.1-4.94.9-5.0-4.94.9-4.8-5.0-4.5
Bone: stiffness2.03.35.1-2.1-1.8-1.8-1.8-1.71.7-1.8-1.81.8-1.8-2.3-1.5
Tibialis anterior weight0.72.53.9-2.0-1.6-1.6-1.6-1.41.4-1.6-1.51.5-1.4-1.9-1.2
Time to tail flick, vehicle, before self-admin0.10.10.50.40.30.30.30.7-0.00.30.2-0.20.30.20.3
Time to tail flick, vehicle, after self-admin0.50.71.00.50.70.70.70.6-1.00.80.9-0.90.90.90.9
Time to tail flick, test, before self-admin0.20.20.40.60.50.50.50.6-0.30.40.3-0.30.30.40.2
Time to tail flick, test, after self-admin0.10.20.40.40.40.40.4-0.0-0.60.40.4-0.40.40.40.3
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.5-0.3-0.3-0.3-0.7-0.2-0.20.0-0.0-0.1-0.0-0.0
Delta time to tail flick, test, before/after SA0.10.10.3-0.10.10.10.1-0.3-0.50.20.4-0.40.30.30.4
Tibia length0.92.42.51.51.61.61.61.6-1.61.61.6-1.61.61.51.5
Ambulatory time before self-admin0.40.51.0-0.5-0.7-0.7-0.7-1.00.7-0.7-0.70.7-0.8-0.6-0.9
Ambulatory time after self-admin0.00.00.2-0.0-0.2-0.2-0.2-0.40.2-0.2-0.20.2-0.2-0.1-0.3
Bone: tissue strength2.52.52.6-1.4-1.6-1.6-1.6-1.61.6-1.6-1.61.6-1.6-1.6-1.6
Total heroin consumption1.41.62.21.51.31.31.31.4-1.21.31.2-1.21.21.31.0
Bone: trabecular number0.10.20.91.00.60.60.60.4-0.40.40.3-0.30.20.30.1
Bone: trabecular spacing0.10.11.1-1.0-0.4-0.4-0.4-0.10.1-0.2-0.10.00.0-0.10.2
Bone: trabecular thickness0.91.22.50.1-0.8-0.8-0.8-1.11.1-1.0-1.21.2-1.4-1.1-1.6
Bone: trabecular tissue density0.91.32.2-1.5-1.2-1.2-1.2-1.11.1-1.1-1.11.1-1.0-1.3-0.9
Water consumed over 24 hours0.70.91.4-1.0-0.9-0.9-0.9-0.90.9-0.9-1.00.9-0.9-1.2-0.8
Number of responses in last shaping day2.22.42.61.31.51.51.51.6-1.61.61.6-1.61.61.61.6