Hub : Genes

Spint2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr1_93692810_93707701 0.03 0.02 3.1e-03 0.01 -0 0 0 7.1e-02 4.8e-01 1.1e-01 2.8e-01
2 Liver isoform ratio NM_001082549.1 0.08 0.06 3.4e-07 0.04 0.04 0.04 0.04 7.6e-05 1.5e-05 4.1e-05 6.7e-05
3 Liver intron excision ratio chr1_93689399_93707701 0.09 0.06 4.4e-07 0.03 0.04 0.04 0.04 1.5e-04 3.1e-05 8.8e-05 7.9e-05
4 pVTA gene expression Spint2 0.1 0.08 4.3e-04 0.04 -0 0.03 0.01 3.3e-04 5.5e-01 1.4e-03 1.0e-01
5 Liver gene expression Spint2 0.52 0.15 0.0e+00 0.32 0.31 0.32 0.31 5.3e-36 9.1e-35 1.5e-35 3.5e-35
6 Adipose gene expression Spint2 0.29 0.15 0.0e+00 0.13 0.13 0.13 0.13 1.7e-14 1.3e-14 6.6e-14 4.4e-14
7 Liver intron excision ratio chr1_93689399_93692640 0.04 0.04 5.5e-04 0.01 0.01 0 0.01 1.1e-02 1.2e-02 1.5e-01 1.7e-02
8 Liver isoform ratio NM_199087.1 0.11 0.07 1.2e-07 0.04 0.04 0.04 0.04 4.6e-05 9.0e-06 3.2e-05 2.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.00.00.00.10.1-0.1-0.00.10.1-0.0-0.1
Area under the delay curve0.10.10.5-0.7-0.20.20.00.00.0-0.0-0.0
BMI with tail0.10.20.40.60.5-0.50.3-0.30.40.4-0.4
BMI without tail0.61.92.4-1.3-1.41.4-1.41.5-1.3-1.51.4
Body weight2.611.211.7-3.2-3.43.3-3.43.4-3.3-3.43.3
Weight adjusted by age0.00.00.10.20.0-0.0-0.00.1-0.0-0.00.0
Bone surface0.40.71.0-0.8-0.80.8-0.91.0-0.8-0.90.8
Bone volume0.50.81.1-0.9-0.90.8-1.01.0-0.8-1.00.8
Breakpoint value in progressive ratio session1.41.72.1-1.4-1.41.4-1.21.2-1.3-1.21.3
Number of licking bursts1.72.83.61.91.7-1.61.7-1.71.51.7-1.6
Context. condit. distance diff. score0.10.10.20.40.3-0.30.4-0.30.40.3-0.4
Locomotion velocity, session 12.72.93.51.41.7-1.61.9-1.91.71.8-1.7
Locomotion distance, session 10.70.91.0-0.9-1.01.0-0.80.9-1.0-0.91.0
Locomotion velocity, session 20.40.50.70.90.7-0.70.6-0.60.70.6-0.7
Locomotion distance, session 20.50.71.31.10.8-0.80.8-0.70.70.8-0.7
Locomotion velocity, session 30.20.20.40.60.4-0.40.4-0.40.40.5-0.4
Locomotion distance, session 36.77.27.9-2.5-2.72.7-2.72.8-2.7-2.82.7
Stereotopy head waving bouts, day 30.50.61.01.00.7-0.70.8-0.70.70.8-0.6
Stereotopy head waving duration, day 32.63.13.51.91.7-1.81.8-1.71.81.7-1.7
Locomotion velocity, session 70.00.00.0-0.1-0.10.1-0.20.2-0.0-0.20.1
Locomotion distance, session 70.10.20.3-0.4-0.40.4-0.40.5-0.4-0.50.4
Stereotopy head waving bouts, day 70.20.20.40.60.5-0.50.4-0.40.40.3-0.4
Stereotopy head waving duration, day 70.81.01.31.11.1-1.01.0-0.90.90.9-1.0
Locomotion velocity, session 83.44.15.22.32.0-2.02.0-2.02.02.0-1.9
Locomotion distance, session 80.50.71.01.00.8-0.80.9-0.80.80.8-0.8
Degree of sensitization distance3.63.74.01.71.9-1.91.9-1.92.02.0-2.0
Degree of sensitization stereotypy0.00.00.00.10.00.0-0.10.1-0.1-0.10.1
Conditioned locomotion0.50.60.8-0.2-0.80.8-0.80.7-0.9-0.80.9
Cocaine response after cond. corrected0.60.70.9-0.7-0.80.8-0.90.9-0.8-0.90.8
Cocaine response after cond. not corrected0.81.01.2-0.7-0.90.9-1.11.1-1.0-1.11.0
Cocaine response before conditioning1.31.62.0-0.9-1.31.3-1.21.3-1.3-1.31.4
Saline control response0.10.10.2-0.2-0.30.3-0.40.4-0.3-0.40.3
Bone: connectivity density0.30.50.60.60.7-0.70.7-0.60.80.6-0.8
Bone: cortical apparent density2.63.54.01.91.9-1.92.0-1.81.81.8-1.8
Bone: cortical area2.64.04.2-1.9-2.02.0-2.12.0-2.0-1.92.0
Bone: cortical porosity0.30.30.91.00.6-0.60.4-0.40.50.5-0.4
Bone: cortical porosity0.40.51.21.10.7-0.70.5-0.60.60.6-0.5
Bone: cortical thickness1.42.42.6-1.4-1.61.6-1.61.5-1.6-1.51.6
Bone: cortical thickness0.00.10.20.50.1-0.10.1-0.20.10.3-0.0
Bone: cortical tissue density2.94.04.52.02.0-2.02.1-1.91.92.0-2.0
Condit. Reinf. active minus inactive responses0.40.40.60.50.6-0.60.8-0.70.60.8-0.6
Condit. Reinf. active-inactive response ratio0.20.20.30.40.4-0.40.6-0.50.50.6-0.4
Condit. Reinf. active responses1.11.41.71.31.2-1.21.2-1.21.11.2-1.1
Condit. Reinf. inactive responses0.70.91.21.11.0-1.00.9-0.90.80.9-0.9
Incentive salience index mean0.00.00.10.20.2-0.20.3-0.20.20.3-0.1
Condit. Reinf. lever presses0.10.10.2-0.3-0.40.4-0.40.4-0.4-0.30.4
Condit. Reinf. active minus inactive responses3.74.85.0-2.1-2.22.2-2.12.2-2.2-2.12.2
Condit. Reinf. active-inactive response ratio2.52.93.3-1.4-1.71.7-1.71.7-1.8-1.71.8
Condit. Reinf. active responses4.46.16.5-2.5-2.52.5-2.42.4-2.5-2.42.5
Condit. Reinf. inactive responses1.11.52.2-1.5-1.31.3-1.11.1-1.1-1.11.1
Condit. Reinf. lever presses6.79.211.9-3.4-3.13.1-2.92.9-3.0-2.82.9
Condit. Reinf. lever reinforcers received5.47.57.9-2.7-2.82.8-2.72.7-2.7-2.72.8
Conditioned reinforcement - actives0.00.10.10.40.3-0.40.2-0.20.30.1-0.3
Conditioned reinforcement - inactives0.60.91.1-0.9-0.90.9-1.01.0-0.9-1.01.0
Conditioned locomotion1.82.33.41.81.6-1.61.5-1.41.51.3-1.4
Patch foraging indifference point 0 sec0.20.40.4-0.5-0.60.6-0.60.5-0.6-0.60.6
Patch foraging indifference point AUC0.30.40.50.70.7-0.70.7-0.40.60.5-0.6
Delay disc. indifference point, 0s delay0.30.31.0-1.0-0.50.5-0.40.5-0.4-0.30.4
Delay disc. indifference point, 16s delay1.21.32.8-1.7-1.11.1-0.91.2-1.0-1.00.9
Delay disc. indifference point, 2s delay0.10.10.2-0.40.1-0.20.3-0.30.40.3-0.4
Delay disc. indifference point, 24s delay1.21.42.0-1.4-1.21.2-1.11.3-1.1-1.11.1
Delay disc. indifference point, 4s delay0.00.00.2-0.5-0.20.2-0.1-0.0-0.1-0.10.1
Delay disc. indifference point, 8s delay0.91.11.30.61.0-1.01.1-1.11.11.1-1.1
Indifference point function ln k0.20.30.5-0.7-0.60.6-0.60.4-0.6-0.50.6
Indifference point function log k0.20.30.5-0.7-0.60.6-0.60.4-0.6-0.50.6
Patch foraging total patch changes 0 sec0.20.50.5-0.6-0.70.7-0.70.6-0.7-0.70.7
Patch foraging total patch changes 12 sec0.30.30.4-0.5-0.60.5-0.60.7-0.6-0.60.6
Patch foraging total patch changes 18 sec0.10.20.30.50.5-0.50.4-0.40.40.3-0.4
Patch foraging total patch changes 24 sec0.40.71.0-1.0-0.80.8-0.80.9-0.8-0.80.8
Patch foraging total patch changes 6 sec0.10.10.1-0.1-0.30.3-0.40.4-0.3-0.40.3
Patch foraging time to switch 0 sec0.71.51.71.21.2-1.21.1-1.21.31.2-1.3
Patch foraging water rate 0 sec0.30.71.11.10.8-0.80.8-0.90.70.8-0.7
Patch foraging water rate 12 sec0.51.01.3-1.1-1.11.1-0.90.7-1.1-0.91.0
Patch foraging water rate 18 sec0.61.01.50.70.9-0.91.0-1.21.01.2-1.0
Patch foraging water rate 24 sec0.20.30.4-0.6-0.60.6-0.40.3-0.6-0.40.6
Patch foraging water rate 6 sec0.00.00.2-0.4-0.20.2-0.1-0.0-0.2-0.10.2
Seeking ratio, delayed vs. immediate footshock1.31.61.9-1.2-1.31.3-1.31.3-1.2-1.41.2
Distance traveled before self-admin2.12.73.1-1.5-1.71.7-1.81.4-1.8-1.41.7
Distance traveled after self-admin2.83.53.9-1.9-1.91.9-2.01.8-1.9-1.71.9
Extensor digitorum longus weight0.20.91.00.91.0-1.01.0-1.01.01.0-1.0
Bone: elastic displacement0.00.00.00.10.1-0.10.2-0.10.10.1-0.1
Bone: elastic work2.73.53.6-1.9-1.91.9-1.81.8-1.9-1.81.9
Bone: endosteal estimation1.22.63.1-1.8-1.61.5-1.61.7-1.5-1.71.5
Bone: endosteal perimeter0.92.02.7-1.6-1.41.4-1.41.3-1.3-1.31.3
Epididymis fat weight0.00.00.1-0.0-0.10.1-0.20.2-0.2-0.20.2
Delta time in closed arm before/after self-admin0.00.00.2-0.40.0-0.00.10.30.1-0.1-0.1
Delta time in open arm before/after self-admin0.10.10.20.1-0.30.3-0.30.0-0.4-0.20.4
Diff in mean of infusions in LGA sessions0.00.00.0-0.1-0.10.10.1-0.1-0.10.10.1
Delay discount exponential model param0.10.10.50.70.2-0.20.0-0.10.10.1-0.0
Extinction: sum of active levers before priming2.32.62.7-1.6-1.61.6-1.61.6-1.6-1.61.6
Active lever presses in extinction session 60.30.30.8-0.9-0.50.5-0.50.6-0.4-0.50.4
Bone: final force1.82.83.0-1.7-1.71.7-1.61.7-1.7-1.61.7
Bone: final moment2.84.54.6-2.1-2.12.1-2.12.1-2.1-2.12.1
Food consumed during 24 hour testing period0.20.30.3-0.5-0.60.6-0.50.3-0.5-0.40.5
Glucose0.10.10.20.20.5-0.50.4-0.20.40.3-0.5
Heart weight1.11.82.0-1.0-1.41.3-1.41.4-1.3-1.41.4
Delay discount hyperbolic model param0.00.00.20.50.0-0.0-0.20.2-0.1-0.10.2
Intermittent access intake day 1-15 change0.30.60.9-0.9-0.70.7-0.80.9-0.6-0.90.6
Intermittent access intake escalation0.20.40.5-0.7-0.50.5-0.60.7-0.5-0.70.5
Intermittent access intake escalation 22.32.63.0-1.7-1.51.5-1.61.7-1.5-1.71.5
Intermitt. access day 1 inactive lever presses1.34.86.1-2.5-2.22.2-2.02.2-2.1-2.22.1
Intermitt. access day 15 inactive lever presses0.40.91.4-1.2-0.91.0-0.90.8-0.9-0.90.9
Intermitt. access escalation Index0.30.40.5-0.4-0.60.7-0.60.6-0.7-0.50.7
Intermittent access day 1 total infusions0.20.31.21.10.4-0.40.3-0.80.30.5-0.3
Intermittent access day 15 total infusions0.10.10.2-0.1-0.40.3-0.50.1-0.3-0.40.4
Intermittent access terminal intake (last 3 days)0.60.81.2-0.7-0.90.9-1.10.7-1.0-1.01.0
Intermittent access total infusions0.00.00.10.1-0.10.1-0.3-0.2-0.1-0.10.2
Intermittent access day 1 locomotion0.00.00.10.3-0.10.1-0.1-0.1-0.1-0.10.2
Intermittent access day 15 total locomotion0.00.00.20.40.1-0.20.1-0.10.2-0.0-0.1
Intermittent access total locomotion0.20.30.60.80.5-0.50.4-0.50.50.3-0.4
Intermittent access standard deviation1.63.34.3-2.1-1.91.9-1.81.6-1.7-1.71.8
Left kidney weight3.516.518.5-3.5-4.04.0-4.14.3-4.1-4.24.2
Right kidney weight3.515.717.0-3.6-3.94.0-4.04.1-4.0-4.14.0
Cocaine induced anxiety0.40.61.00.30.7-0.70.8-0.80.81.0-0.8
Post-drug Anxiety0.00.00.1-0.40.0-0.00.2-0.20.10.3-0.1
Baseline Anxiety1.51.82.1-0.9-1.31.3-1.41.4-1.4-1.51.4
Tail length5.722.224.2-4.9-4.74.6-4.74.8-4.6-4.84.5
Length with tail7.131.033.3-5.8-5.65.6-5.55.6-5.4-5.65.4
Length without tail1.85.76.8-2.6-2.42.4-2.32.3-2.3-2.42.3
Times rat made contact with spout0.50.51.21.10.7-0.70.7-0.60.60.6-0.6
Lifetime Intake0.10.10.20.50.2-0.2-0.0-0.40.10.1-0.1
Liver weight, left0.30.40.7-0.3-0.50.5-0.70.8-0.7-0.80.7
Liver weight, right0.00.10.1-0.2-0.20.2-0.30.3-0.3-0.30.3
Locomotor activity0.40.61.01.00.8-0.80.5-0.60.70.8-0.7
Locomotor testing distance1.12.02.31.51.4-1.41.4-1.41.31.5-1.3
Locomotor testing rearing1.12.33.21.81.5-1.51.4-1.51.41.7-1.4
Locomotion in novel chamber0.50.70.80.70.8-0.80.7-0.80.90.8-0.9
Locomotion in novel chamber post-restriction0.00.00.0-0.1-0.10.0-0.1-0.20.10.1-0.1
Fecal boli incidents, locomotor time 12.73.94.41.82.0-2.02.1-1.92.11.8-2.1
Change in fecal boli incidents, locomotor task0.00.00.00.2-0.10.00.10.0-0.00.00.1
Time >=10cm from walls, locomotor time 10.00.00.0-0.00.1-0.10.10.20.1-0.1-0.1
Bouts of movement, locomotor time 10.30.41.2-1.1-0.60.6-0.40.6-0.4-0.60.4
Total resting periods, locomotor time 10.20.20.9-0.9-0.50.4-0.30.4-0.2-0.40.2
Rest time, locomotor task time 10.10.10.10.30.3-0.30.3-0.30.30.1-0.3
Distance moved, locomotor task time 10.20.20.5-0.1-0.40.4-0.50.7-0.5-0.60.5
Vertical activity count, locomotor time 10.71.72.1-1.0-1.31.2-1.31.5-1.3-1.41.3
Time >=10cm from walls, locomotor time 20.10.10.2-0.2-0.20.2-0.10.4-0.3-0.40.3
Bouts of movement, locomotor time 20.30.50.8-0.00.5-0.60.9-0.60.80.8-0.8
Total resting periods, locomotor time 20.30.51.00.10.6-0.61.0-0.60.80.8-0.8
Rest time, locomotor task time 20.30.40.5-0.4-0.60.6-0.60.7-0.7-0.70.7
Distance moved, locomotor task time 20.00.00.00.20.2-0.20.10.00.10.1-0.1
Vertical activity count, locomotor time 20.10.20.3-0.5-0.40.4-0.40.5-0.4-0.50.4
Light reinforcement 10.10.30.50.50.5-0.60.6-0.60.60.7-0.5
Light reinforcement 26.510.011.03.03.1-3.13.1-3.33.23.2-3.2
Bone: marrow area1.22.73.2-1.8-1.61.6-1.61.7-1.6-1.71.5
Bone: maximum diameter1.63.03.3-1.7-1.71.7-1.81.8-1.7-1.71.7
Bone: maximum force3.35.96.5-2.5-2.42.4-2.42.4-2.4-2.42.4
Bone: maximum moment4.57.98.3-2.9-2.82.8-2.82.8-2.8-2.72.8
Mean time between licks in bursts0.10.10.2-0.3-0.40.4-0.30.4-0.4-0.40.4
Mean num. licks in bursts0.71.11.2-1.0-1.01.0-1.11.1-1.0-1.11.0
Cd content in liver0.60.70.80.90.8-0.80.9-0.80.80.8-0.8
Co content in liver1.11.21.61.31.1-1.11.1-1.11.11.0-1.1
Cu content in liver1.11.41.5-1.2-1.21.2-1.11.0-1.2-1.01.2
Fe content in liver0.91.01.20.81.1-1.11.0-0.91.11.0-1.1
K content in liver0.80.80.9-0.8-0.90.9-0.90.9-0.9-0.80.9
Mg content in liver0.10.10.2-0.1-0.30.3-0.30.3-0.4-0.30.4
Mn content in liver0.80.91.2-0.3-0.90.9-1.01.1-1.1-1.01.1
Na content in liver3.33.64.0-1.8-1.81.8-1.92.0-1.9-1.91.9
Rb content in liver0.00.00.0-0.1-0.10.1-0.1-0.1-0.1-0.00.1
Se content in liver2.73.24.72.21.9-1.81.6-1.71.71.7-1.7
Sr content in liver0.40.30.50.70.6-0.60.6-0.60.60.6-0.6
Zn content in liver2.32.53.71.91.6-1.61.5-1.61.51.6-1.4
Bone: minimum diameter6.111.211.8-3.3-3.43.4-3.43.3-3.3-3.33.3
Time in familiar zone, hab. session 10.30.30.4-0.6-0.50.5-0.50.6-0.5-0.60.5
Time in novel zone, hab. session 10.10.10.20.50.3-0.30.3-0.30.30.3-0.3
Total zone transitions, hab. session 10.50.70.8-0.8-0.80.8-0.80.9-0.9-0.80.9
Total locomotion distance, hab. session 12.94.14.9-2.2-2.02.1-1.92.0-2.0-2.02.0
Locomotion velocity, hab. session 11.21.62.1-1.4-1.31.3-1.21.2-1.3-1.21.3
Time in familiar zone, hab. session 20.30.30.9-1.0-0.60.6-0.50.6-0.4-0.50.4
Time in novel zone, hab. session 20.50.50.70.90.7-0.70.7-0.70.60.7-0.6
Total zone transitions, hab. session 20.10.10.40.70.3-0.20.3-0.20.10.2-0.1
Total locomotion distance, hab. session 20.30.40.5-0.5-0.70.7-0.50.6-0.7-0.60.7
Locomotion velocity, hab. session 20.20.30.5-0.3-0.60.6-0.50.5-0.7-0.50.7
Novel to familiar place preference ratio1.41.51.7-1.1-1.21.2-1.31.2-1.3-1.31.2
Novelty place preference1.21.31.5-1.1-1.11.1-1.21.1-1.2-1.21.1
Time in novel zone, NPP test0.80.81.0-0.8-0.80.9-1.00.9-1.0-1.00.9
Total zone transitions, NPP test0.20.20.30.40.5-0.50.5-0.50.50.4-0.5
Total locomotion distance, NPP test1.52.02.7-1.7-1.51.5-1.31.3-1.4-1.31.4
Locomotion velocity, NPP test1.92.73.5-1.9-1.71.7-1.51.5-1.6-1.61.6
Intraocular pressure0.00.10.10.10.3-0.30.4-0.20.30.2-0.4
Delta distance traveled before/after self-admin0.00.00.1-0.20.2-0.20.20.00.30.1-0.3
Delta ambulatory time before/after self-admin0.10.10.2-0.4-0.20.2-0.20.5-0.2-0.40.2
Parametrial fat weight0.10.30.60.80.5-0.50.4-0.50.50.6-0.4
Pavlov. Cond. lever latency0.30.40.60.40.6-0.60.8-0.70.70.6-0.7
Pavlov. Cond. magazine entry latency0.30.40.50.40.6-0.60.7-0.70.60.7-0.6
Pavlov. Cond. change in total contacts0.00.00.0-0.00.00.00.00.1-0.00.00.0
Pavlov. Cond. index score0.00.00.00.1-0.00.0-0.10.1-0.1-0.00.1
Pavlov. Cond. latency score0.00.00.1-0.1-0.20.2-0.30.3-0.3-0.20.3
Pavlov. Cond. lever contacts0.80.91.1-0.8-0.90.9-1.01.0-1.0-0.91.0
Pavlov. Cond. magazine entry number0.10.10.2-0.1-0.30.3-0.40.3-0.3-0.40.3
Pavlov. Cond. intertrial magazine entries0.10.10.40.70.4-0.40.4-0.30.30.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.0-0.10.1-0.20.2-0.2-0.10.2
Pavlov. Cond. response bias0.00.00.0-0.2-0.10.1-0.10.1-0.2-0.00.2
Pavlov. Cond. lever latency3.64.96.42.52.3-2.32.1-2.12.12.0-2.1
Pavlov. Cond. magazine entry latency2.02.43.8-2.0-1.61.6-1.41.5-1.5-1.51.5
Pavlov. Cond. change in total contacts5.18.210.8-3.3-3.03.0-2.72.7-2.8-2.62.8
Pavlov. Cond. index score3.34.56.8-2.6-2.22.2-2.02.0-2.0-1.92.0
Pavlov. Cond. latency score2.93.95.9-2.4-2.02.0-1.81.8-1.9-1.81.9
Pavlov. Cond. lever contacts4.05.57.4-2.7-2.42.4-2.32.2-2.3-2.22.3
Pavlov. Cond. magazine entry number1.31.73.41.81.3-1.31.1-1.11.11.1-1.1
Pavlov. Cond. intertrial magazine entries0.91.32.21.51.2-1.11.0-1.11.01.1-1.0
Pavlov. Cond. lever-magazine prob. diff.3.64.87.0-2.6-2.22.2-2.12.1-2.1-2.12.1
Pavlov. Cond. response bias4.76.48.6-2.9-2.62.6-2.42.4-2.5-2.42.4
Time in closed arm before self-admin0.10.10.30.60.2-0.20.2-0.50.10.3-0.1
Time in closed arm after self-admin0.00.00.1-0.20.0-0.10.3-0.10.20.1-0.3
Time in open arm before self-admin1.11.21.5-1.2-1.01.0-1.11.2-1.0-1.01.0
Time in open arm after self-admin2.02.22.7-1.0-1.51.5-1.61.5-1.6-1.51.7
Bone: periosteal estimation2.65.45.7-2.4-2.32.3-2.42.4-2.3-2.32.3
Bone: periosteal perimeter2.13.64.1-2.0-1.91.9-2.01.8-1.9-1.91.9
Bone: post-yield work0.91.42.3-1.5-1.21.2-1.11.1-1.1-1.01.1
Progressive ratio test 1 active lever presses0.30.40.80.0-0.60.6-0.90.4-0.7-0.60.7
Progressive ratio test 1 breakpoint0.50.61.1-0.2-0.80.8-1.00.6-0.9-0.80.9
Progressive ratio test 1 inactive lever presses0.50.71.0-0.8-0.90.9-1.00.7-0.9-0.80.9
Progressive ratio test 2 active lever presses0.10.10.30.50.3-0.30.1-0.50.30.2-0.3
Progressive ratio test 2 breakpoint0.10.10.30.60.3-0.30.2-0.50.30.3-0.3
Progressive ratio test 2 inactive lever presses0.40.61.0-1.0-0.90.8-0.80.5-0.7-0.80.7
Incentive Sensitization - Responses0.40.50.70.70.7-0.70.7-0.90.70.7-0.7
Incentive Sensitization - Breakpoint0.50.60.80.70.8-0.80.7-0.90.80.7-0.8
Sum of active levers in priming session hrs 5-60.00.00.10.30.1-0.10.30.00.10.2-0.0
Progressive ratio0.61.01.30.41.0-1.01.1-0.91.11.0-1.1
Food seeking constrained by brief footshock2.22.73.6-1.9-1.71.7-1.51.5-1.6-1.61.6
Seeking ratio, punishment vs. effort1.31.92.2-1.1-1.51.5-1.41.2-1.5-1.31.5
Retroperitoneal fat weight0.41.62.31.51.3-1.31.2-1.21.21.3-1.2
Reaction time number correct0.00.00.10.1-0.10.1-0.20.1-0.2-0.10.3
Reaction time mean minus median0.10.20.2-0.4-0.50.5-0.40.5-0.5-0.40.5
Reaction time mean minus median AUC0.20.40.5-0.6-0.60.7-0.60.7-0.7-0.60.7
Reaction time num false alarms0.91.32.01.41.2-1.21.1-1.01.11.0-1.1
Reaction time num false alarms AUC1.21.92.81.71.5-1.41.3-1.31.31.2-1.4
Reaction time trials correct on left0.00.00.10.1-0.10.1-0.20.1-0.2-0.10.3
Reaction time trials on left0.00.00.10.1-0.10.1-0.20.1-0.2-0.10.2
Reaction time mean0.10.10.10.40.3-0.30.3-0.20.20.3-0.3
Reaction time mean AUC0.10.20.30.60.5-0.40.5-0.40.40.5-0.4
Median of all reaction times0.30.40.50.70.7-0.70.6-0.60.60.7-0.6
Reaction time omissions0.20.30.70.80.6-0.60.4-0.50.50.5-0.5
Reaction time false alarm rate1.11.51.81.31.3-1.31.2-1.11.31.1-1.3
Reaction time premature initiation rate0.00.00.1-0.10.0-0.00.1-0.20.10.2-0.1
Reaction time premature initiations0.00.00.00.00.0-0.00.1-0.20.00.2-0.0
Std. dev. reaction times0.00.10.1-0.2-0.30.3-0.20.3-0.4-0.20.4
Reaction time trials completed0.00.00.10.1-0.10.1-0.20.1-0.2-0.10.2
Reaction time trials AUC0.00.00.10.30.0-0.0-0.1-0.0-0.10.00.1
Run reversals in cocaine runway, females0.10.10.10.10.3-0.30.3-0.20.40.4-0.4
Run reversals in cocaine runway, males1.31.32.41.51.0-1.00.9-1.31.01.2-1.0
Latency to leave start box in cocaine runway0.00.00.00.00.1-0.20.20.00.20.1-0.1
Latency to leave start box in cocaine runway, F0.20.30.40.60.5-0.50.6-0.50.50.5-0.5
Latency to leave start box in cocaine runway, M0.10.10.2-0.5-0.30.3-0.30.5-0.3-0.40.2
Std. dev. time between licks in bursts0.50.60.9-1.0-0.80.8-0.70.8-0.7-0.80.7
Total sessions with >9 infusions0.50.62.01.40.7-0.70.4-0.70.50.6-0.5
Short access day 1 total inactive lever presses0.50.71.7-1.3-0.80.8-0.70.6-0.8-0.70.7
Short access day 10 total inactive lever presses1.12.75.6-2.4-1.61.6-1.31.6-1.4-1.51.4
Short access day 1 total infusions0.50.71.0-0.3-0.90.9-1.00.6-0.9-0.80.9
Short access day 10 total infusions0.10.10.40.70.3-0.20.1-0.50.20.3-0.1
Short access total infusions0.10.20.60.70.4-0.30.1-0.60.30.4-0.2
Short access day 1 locomotion1.01.22.21.51.2-1.21.0-1.01.00.9-1.0
Short access day 10 total locomotion0.50.91.1-0.9-0.90.9-0.90.9-1.0-1.11.0
Short access total locomotion0.10.10.30.60.2-0.20.2-0.20.10.0-0.0
One hour access (0.3 mA shock)0.40.40.7-0.9-0.70.7-0.70.6-0.6-0.70.6
Compulsive drug intake2.73.23.5-1.9-1.71.8-1.81.7-1.9-1.81.8
One hour access (shock baseline)0.10.10.20.30.3-0.30.2-0.40.40.2-0.3
Social response proportion4.14.65.4-1.8-2.22.2-2.32.1-2.2-2.12.2
Social responses0.10.10.2-0.3-0.40.3-0.50.3-0.3-0.40.3
Social time0.40.61.1-1.0-0.80.8-0.70.6-0.6-0.70.6
Soleus weight0.82.22.41.31.5-1.51.5-1.51.61.6-1.6
Bone: stiffness1.62.52.9-1.7-1.61.6-1.61.6-1.6-1.51.5
Tibialis anterior weight0.00.00.10.30.1-0.10.1-0.10.10.1-0.1
Time to tail flick, vehicle, before self-admin0.00.00.10.2-0.10.1-0.20.2-0.2-0.20.3
Time to tail flick, vehicle, after self-admin0.30.40.6-0.8-0.70.7-0.60.5-0.5-0.60.5
Time to tail flick, test, before self-admin0.20.20.30.50.5-0.50.5-0.20.50.3-0.4
Time to tail flick, test, after self-admin0.10.10.10.30.3-0.30.4-0.10.40.2-0.3
Delta time to tail flick, vehicle, before/after SA0.30.30.4-0.6-0.60.6-0.50.6-0.5-0.60.5
Delta time to tail flick, test, before/after SA0.00.00.00.1-0.10.1-0.2-0.1-0.1-0.00.1
Tibia length2.15.75.9-2.3-2.42.4-2.42.4-2.4-2.42.4
Ambulatory time before self-admin1.42.02.3-1.4-1.51.5-1.51.2-1.5-1.21.5
Ambulatory time after self-admin2.93.44.0-2.0-1.91.9-1.81.8-1.8-1.61.8
Bone: tissue strength5.15.15.6-2.4-2.22.2-2.22.3-2.3-2.32.2
Total heroin consumption0.91.11.3-0.9-1.11.1-1.01.0-1.2-1.01.1
Bone: trabecular number0.10.20.2-0.4-0.40.4-0.50.4-0.3-0.40.4
Bone: trabecular spacing1.72.22.6-1.6-1.51.5-1.51.4-1.5-1.41.5
Bone: trabecular thickness0.10.10.40.60.3-0.30.2-0.20.30.3-0.3
Bone: trabecular tissue density2.23.23.51.71.9-1.91.8-1.71.81.7-1.8
Water consumed over 24 hours0.71.01.2-0.5-1.01.0-1.11.0-1.0-1.11.1
Number of responses in last shaping day0.50.50.6-0.3-0.80.7-0.80.7-0.7-0.80.7