Hub : Genes

Spint2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	NM_001082549.1	0.08	0.06	3.5e-07	0.04	0.04	0.04	0.04	8.7e-05	3.1e-05	5.8e-05	6.8e-05
2	Liver	intron excision ratio	chr1_84565335_84580226	0.03	0.03	5.6e-03	0	-0	0	0	1.1e-01	5.7e-01	3.5e-01	3.4e-01
3	Liver	intron excision ratio	chr1_84561924_84580226	0.1	0.07	3.9e-07	0.03	0.04	0.03	0.04	1.7e-04	2.6e-05	1.4e-04	7.7e-05
4	Adipose	gene expression	Spint2	0.27	0.15	5.6e-17	0.12	0.1	0.1	0.11	6.1e-13	1.1e-11	1.1e-11	1.7e-12
5	Liver	intron excision ratio	chr1_84561924_84565165	0.04	0.04	7.1e-04	0.01	0.01	0.01	0.01	1.3e-02	1.4e-02	2.5e-02	2.7e-02
6	Liver	gene expression	Spint2	0.44	0.14	0.0e+00	0.27	0.26	0.26	0.26	4.5e-30	2.0e-28	1.5e-28	6.1e-29

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.1	0.1	0.3	-0.2	-0.4	-0.2	-0.2	0.2
Area under the delay curve	0.0	0.0	0.1	-0.2	0.4	-0.1	-0.1	-0.0	0.1
BMI with tail	0.1	0.3	0.5	0.7	-0.7	-0.5	-0.5	-0.5	0.5
BMI without tail	0.2	0.5	0.7	-0.6	0.7	0.6	0.8	0.7	-0.8
Body weight	3.0	12.5	12.8	-3.5	3.5	3.5	3.5	3.6	-3.6
Weight adjusted by age	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.4	-0.4	0.3
Bone surface	0.3	0.5	0.7	-0.6	0.7	0.6	0.7	0.8	-0.8
Bone volume	0.3	0.5	0.7	-0.6	0.7	0.6	0.7	0.8	-0.8
Breakpoint value in progressive ratio session	1.3	1.4	2.1	-1.4	1.0	1.2	1.3	1.1	-1.1
Number of licking bursts	2.4	2.8	3.2	1.7	-1.8	-1.5	-1.8	-1.7	1.6
Context. condit. distance diff. score	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.3	0.3
Locomotion velocity, session 1	2.8	3.1	3.4	1.6	-1.7	-1.7	-1.8	-1.8	1.8
Locomotion distance, session 1	0.8	1.0	1.1	-1.0	1.0	1.0	1.0	1.0	-1.0
Locomotion velocity, session 2	0.3	0.3	0.5	0.7	-0.5	-0.7	-0.5	-0.5	0.5
Locomotion distance, session 2	0.4	0.5	0.7	0.9	-0.8	-0.7	-0.7	-0.7	0.7
Locomotion velocity, session 3	0.2	0.3	0.3	0.5	-0.6	-0.4	-0.5	-0.5	0.5
Locomotion distance, session 3	6.4	6.9	7.4	-2.6	2.6	2.6	2.7	2.7	-2.7
Stereotopy head waving bouts, day 3	0.6	0.7	1.0	0.8	-1.0	-0.7	-0.9	-0.9	0.9
Stereotopy head waving duration, day 3	2.8	3.4	3.5	1.8	-1.9	-1.8	-1.9	-1.8	1.8
Locomotion velocity, session 7	0.0	0.0	0.0	-0.0	0.1	-0.0	0.2	0.0	-0.0
Locomotion distance, session 7	0.1	0.1	0.1	-0.3	0.3	0.3	0.4	0.3	-0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.1	-0.1	0.1
Stereotopy head waving duration, day 7	0.9	1.1	1.3	1.1	-1.1	-1.0	-1.0	-1.0	1.0
Locomotion velocity, session 8	3.4	4.1	4.4	2.0	-2.1	-1.9	-2.0	-2.0	2.0
Locomotion distance, session 8	0.4	0.5	0.5	0.7	-0.7	-0.7	-0.7	-0.7	0.7
Degree of sensitization distance	3.8	3.8	4.0	1.9	-1.8	-2.0	-2.0	-2.0	2.0
Degree of sensitization stereotypy	0.0	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	-0.1
Conditioned locomotion	0.4	0.5	0.7	-0.6	0.5	0.8	0.7	0.7	-0.8
Cocaine response after cond. corrected	0.5	0.5	0.6	-0.6	0.6	0.7	0.8	0.8	-0.8
Cocaine response after cond. not corrected	0.8	0.8	1.0	-0.8	0.8	0.9	1.0	1.0	-0.9
Cocaine response before conditioning	1.5	1.8	2.2	-1.3	1.2	1.5	1.3	1.4	-1.3
Saline control response	0.4	0.6	0.6	-0.7	0.7	0.8	0.8	0.8	-0.8
Bone: connectivity density	0.4	0.7	1.0	0.9	-0.7	-1.0	-0.8	-0.8	0.7
Bone: cortical apparent density	2.2	2.9	3.2	1.7	-1.8	-1.6	-1.7	-1.7	1.7
Bone: cortical area	2.2	3.3	3.5	-1.8	1.7	1.9	1.8	1.8	-1.8
Bone: cortical porosity	0.6	0.7	0.9	1.0	-0.9	-0.8	-0.7	-0.7	0.7
Bone: cortical porosity	0.7	0.8	1.0	1.0	-1.0	-0.8	-0.8	-0.8	0.8
Bone: cortical thickness	0.9	1.5	1.7	-1.2	1.1	1.3	1.2	1.1	-1.2
Bone: cortical thickness	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.3	-0.3	0.2
Bone: cortical tissue density	2.6	3.5	3.8	1.9	-1.9	-1.8	-1.8	-1.9	1.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.5	0.6	-0.7	-0.5	-0.7	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.5	-0.6	-0.5	-0.7	-0.6	0.6
Condit. Reinf. active responses	1.1	1.3	1.6	1.2	-1.3	-1.1	-1.1	-1.1	1.1
Condit. Reinf. inactive responses	0.5	0.6	0.9	1.0	-0.9	-0.8	-0.6	-0.7	0.7
Incentive salience index mean	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.2	-0.2	0.2
Condit. Reinf. lever presses	0.1	0.2	0.2	-0.4	0.4	0.4	0.5	0.5	-0.5
Condit. Reinf. active minus inactive responses	4.1	5.1	5.4	-2.3	2.2	2.3	2.3	2.2	-2.1
Condit. Reinf. active-inactive response ratio	2.8	2.9	3.5	-1.7	1.5	1.9	1.7	1.7	-1.7
Condit. Reinf. active responses	4.6	6.4	7.0	-2.6	2.5	2.6	2.6	2.5	-2.4
Condit. Reinf. inactive responses	1.4	1.7	2.2	-1.4	1.5	1.2	1.3	1.2	-1.2
Condit. Reinf. lever presses	6.4	8.7	10.2	-3.2	3.1	3.0	2.9	2.8	-2.7
Condit. Reinf. lever reinforcers received	5.5	7.7	8.4	-2.9	2.8	2.9	2.8	2.7	-2.6
Conditioned reinforcement - actives	0.4	0.4	0.6	-0.5	0.8	0.5	0.5	0.7	-0.6
Conditioned reinforcement - inactives	2.3	2.6	2.7	-1.6	1.6	1.6	1.6	1.6	-1.6
Conditioned locomotion	1.1	1.3	1.6	1.3	-1.0	-1.2	-1.3	-1.0	1.1
Patch foraging indifference point 0 sec	0.2	0.4	0.4	-0.6	0.7	0.7	0.6	0.6	-0.6
Patch foraging indifference point AUC	0.3	0.3	0.4	0.6	-0.5	-0.5	-0.6	-0.5	0.5
Delay disc. indifference point, 0s delay	0.4	0.5	1.1	-0.7	1.0	0.6	0.6	0.5	-0.5
Delay disc. indifference point, 16s delay	1.2	1.2	2.0	-1.2	1.4	0.9	0.9	1.0	-1.0
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.1	0.2	-0.3	-0.3	-0.2	0.2
Delay disc. indifference point, 24s delay	1.4	1.3	1.7	-1.2	1.3	1.1	1.1	1.1	-1.1
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	-0.3	0.4	0.2	0.2	0.2	-0.1
Delay disc. indifference point, 8s delay	0.9	1.0	1.2	0.8	-0.8	-1.1	-1.1	-1.0	1.0
Indifference point function ln k	0.3	0.4	0.6	-0.7	0.7	0.7	0.7	0.6	-0.5
Indifference point function log k	0.3	0.4	0.6	-0.7	0.7	0.7	0.7	0.6	-0.5
Patch foraging total patch changes 0 sec	0.3	0.5	0.6	-0.7	0.8	0.7	0.7	0.7	-0.7
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	-0.6	0.7	0.6	0.5	0.6	-0.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.1	0.3	-0.2	-0.3	-0.4	-0.3	0.2
Patch foraging total patch changes 24 sec	0.7	0.8	1.0	-0.9	1.0	0.9	0.8	0.8	-0.9
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.3	0.4	0.4	0.4	0.4	-0.5
Patch foraging time to switch 0 sec	1.1	1.7	2.0	1.3	-1.2	-1.4	-1.3	-1.4	1.3
Patch foraging water rate 0 sec	0.4	0.6	0.9	0.8	-0.9	-0.7	-0.6	-0.7	0.9
Patch foraging water rate 12 sec	0.7	1.1	1.4	-1.1	1.0	1.1	1.2	1.0	-0.9
Patch foraging water rate 18 sec	0.8	1.1	1.6	0.9	-1.1	-1.0	-0.9	-1.2	1.3
Patch foraging water rate 24 sec	0.3	0.4	0.6	-0.7	0.4	0.7	0.8	0.5	-0.4
Patch foraging water rate 6 sec	0.0	0.1	0.1	-0.4	0.2	0.3	0.4	0.2	-0.0
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	1.8	-1.3	1.0	1.2	1.2	1.4	-1.1
Distance traveled before self-admin	1.7	1.9	2.4	-1.5	1.1	1.5	1.5	1.2	-1.3
Distance traveled after self-admin	5.2	5.8	6.4	-2.5	2.5	2.5	2.4	2.2	-2.3
Extensor digitorum longus weight	0.2	0.9	1.1	0.9	-0.9	-0.9	-1.0	-0.9	0.8
Bone: elastic displacement	0.0	0.1	0.1	0.2	-0.2	-0.2	-0.2	-0.3	0.3
Bone: elastic work	2.2	2.8	3.0	-1.7	1.6	1.7	1.7	1.6	-1.7
Bone: endosteal estimation	1.3	2.7	3.0	-1.7	1.7	1.6	1.6	1.7	-1.7
Bone: endosteal perimeter	1.1	2.3	2.7	-1.6	1.7	1.4	1.5	1.5	-1.5
Epididymis fat weight	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.0	0.0
Delta time in closed arm before/after self-admin	0.8	0.8	1.3	-0.7	1.2	0.6	0.8	0.9	-1.0
Delta time in open arm before/after self-admin	0.1	0.1	0.4	0.2	-0.6	-0.0	-0.0	-0.2	0.4
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.3	0.1	0.3	0.1	0.0	-0.0
Delay discount exponential model param	0.0	0.0	0.1	0.2	-0.4	0.0	0.0	-0.0	-0.0
Extinction: sum of active levers before priming	1.3	1.3	1.5	-1.2	1.2	1.1	1.2	1.1	-1.1
Active lever presses in extinction session 6	0.4	0.4	0.8	-0.7	0.9	0.4	0.6	0.4	-0.5
Bone: final force	1.7	2.8	3.0	-1.7	1.7	1.7	1.6	1.7	-1.7
Bone: final moment	2.6	4.2	4.5	-2.1	2.0	2.1	2.0	2.0	-2.1
Food consumed during 24 hour testing period	0.3	0.3	0.4	-0.6	0.6	0.6	0.6	0.4	-0.5
Glucose	0.2	0.3	0.5	0.7	-0.6	-0.7	-0.5	-0.5	0.5
Heart weight	0.7	1.0	1.1	-1.0	0.9	1.1	1.0	1.0	-1.0
Delay discount hyperbolic model param	0.0	0.0	0.1	0.1	-0.3	0.1	0.1	0.1	-0.1
Intermittent access intake day 1-15 change	1.6	1.6	2.2	-1.2	1.5	1.1	1.2	1.3	-1.3
Intermittent access intake escalation	1.2	1.2	1.5	-1.0	1.2	0.9	1.0	1.2	-1.2
Intermittent access intake escalation 2	3.6	3.6	4.0	-1.8	1.9	1.8	1.9	2.0	-2.0
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.7	-0.7	0.8	0.5	0.6	0.5	-0.7
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	-0.5	0.7	0.3	0.3	0.3	-0.3
Intermitt. access escalation Index	0.1	0.1	0.1	-0.3	-0.1	0.3	0.4	0.2	-0.2
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.2	-0.6	-0.0	-0.1	-0.3	0.5
Intermittent access day 15 total infusions	0.7	0.8	1.0	-0.9	0.8	1.0	0.9	0.9	-0.7
Intermittent access terminal intake (last 3 days)	1.3	1.4	1.8	-1.2	1.1	1.3	1.3	1.2	-1.0
Intermittent access total infusions	0.3	0.4	0.6	-0.6	0.5	0.8	0.7	0.6	-0.4
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.2	-0.2	0.0	-0.1	-0.1	0.1
Intermittent access day 15 total locomotion	0.0	0.0	0.0	0.2	0.1	-0.2	-0.2	0.0	-0.0
Intermittent access total locomotion	0.3	0.4	0.5	0.7	-0.4	-0.6	-0.7	-0.5	0.5
Intermittent access standard deviation	4.8	5.1	5.8	-2.4	2.3	2.2	2.3	2.2	-2.1
Left kidney weight	3.0	8.6	9.2	-2.8	2.7	3.0	3.0	2.9	-3.0
Right kidney weight	4.3	12.1	12.6	-3.5	3.4	3.6	3.4	3.5	-3.5
Cocaine induced anxiety	0.0	0.0	0.1	-0.0	0.3	-0.1	-0.1	-0.4	0.2
Post-drug Anxiety	0.5	0.6	1.0	0.6	-0.1	-0.8	-0.8	-1.0	0.8
Baseline Anxiety	0.1	0.1	0.4	0.4	-0.6	-0.2	-0.3	-0.1	0.2
Tail length	5.5	16.6	17.8	-4.1	4.2	3.9	4.1	4.0	-4.0
Length with tail	8.0	29.1	31.0	-5.5	5.6	5.3	5.3	5.4	-5.4
Length without tail	3.5	7.6	8.4	-2.9	2.8	2.8	2.6	2.8	-2.7
Times rat made contact with spout	0.3	0.3	0.5	0.7	-0.7	-0.5	-0.5	-0.5	0.4
Lifetime Intake	0.0	0.0	0.1	-0.1	-0.1	0.2	0.2	0.1	0.2
Liver weight, left	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.1	-0.0	-0.0
Liver weight, right	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.1	-0.1
Locomotor activity	0.3	0.5	0.7	0.8	-0.8	-0.7	-0.5	-0.7	0.7
Locomotor testing distance	0.9	1.6	1.9	1.2	-1.3	-1.2	-1.0	-1.4	1.4
Locomotor testing rearing	1.4	2.1	2.6	1.5	-1.6	-1.3	-1.1	-1.6	1.6
Locomotion in novel chamber	0.3	0.4	0.5	0.6	-0.7	-0.7	-0.6	-0.6	0.6
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.2	-0.2	0.0	0.2	0.0	0.2
Fecal boli incidents, locomotor time 1	3.2	3.5	4.1	1.9	-1.7	-2.0	-1.9	-1.8	1.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.4	0.3	0.5	0.4	0.4	-0.5
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.0	-0.1
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.6	0.6	0.3	0.3	0.4	-0.5
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.5	0.4	0.2	0.3	0.3	-0.3
Rest time, locomotor task time 1	0.0	0.1	0.1	0.3	-0.2	-0.3	-0.2	-0.2	0.2
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.3	0.3	0.4	0.5	0.5	-0.6
Vertical activity count, locomotor time 1	1.4	1.5	1.8	-1.1	1.1	1.2	1.3	1.4	-1.3
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.1	0.1	0.2	0.1	0.2	-0.3
Bouts of movement, locomotor time 2	0.3	0.3	0.6	0.4	-0.0	-0.6	-0.8	-0.7	0.4
Total resting periods, locomotor time 2	0.3	0.3	0.6	0.4	-0.1	-0.6	-0.8	-0.7	0.4
Rest time, locomotor task time 2	0.2	0.3	0.4	-0.5	0.2	0.6	0.6	0.5	-0.6
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.2	-0.0	-0.2	-0.2	-0.1	-0.0
Vertical activity count, locomotor time 2	0.2	0.2	0.3	-0.4	0.6	0.3	0.4	0.6	-0.5
Light reinforcement 1	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.5	-0.5	0.4
Light reinforcement 2	7.3	9.8	10.4	3.1	-3.0	-3.2	-3.1	-3.2	3.2
Bone: marrow area	1.3	2.9	3.1	-1.7	1.8	1.6	1.7	1.7	-1.7
Bone: maximum diameter	1.5	2.8	2.9	-1.7	1.7	1.6	1.7	1.7	-1.7
Bone: maximum force	2.9	5.0	5.2	-2.3	2.2	2.3	2.1	2.2	-2.3
Bone: maximum moment	3.8	6.6	6.9	-2.6	2.6	2.6	2.5	2.5	-2.6
Mean time between licks in bursts	0.1	0.2	0.2	-0.4	0.4	0.4	0.3	0.4	-0.4
Mean num. licks in bursts	1.1	1.3	1.6	-1.0	1.1	1.0	1.2	1.1	-1.2
Cd content in liver	0.4	0.5	0.6	0.6	-0.7	-0.7	-0.7	-0.7	0.8
Co content in liver	2.1	2.4	2.6	1.5	-1.6	-1.5	-1.5	-1.5	1.6
Cu content in liver	1.1	1.4	1.5	-1.2	1.1	1.2	1.1	1.1	-1.2
Fe content in liver	0.3	0.4	0.5	0.6	-0.5	-0.7	-0.6	-0.6	0.6
K content in liver	0.7	0.7	0.8	-0.8	0.7	0.9	0.8	0.8	-0.9
Mg content in liver	0.0	0.0	0.1	-0.1	0.1	0.3	0.2	0.2	-0.2
Mn content in liver	0.5	0.5	0.8	-0.5	0.4	0.9	0.8	0.8	-0.8
Na content in liver	5.9	6.3	6.5	-2.4	2.5	2.5	2.5	2.5	-2.6
Rb content in liver	0.0	0.0	0.0	-0.0	0.1	0.0	-0.0	-0.0	-0.1
Se content in liver	3.0	3.7	4.7	2.1	-2.2	-1.8	-1.8	-1.8	1.8
Sr content in liver	0.8	0.7	0.9	0.9	-0.9	-0.8	-0.8	-0.8	0.9
Zn content in liver	0.3	0.4	0.5	0.6	-0.6	-0.6	-0.6	-0.6	0.7
Bone: minimum diameter	5.6	10.5	11.1	-3.3	3.2	3.3	3.3	3.2	-3.1
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.5	0.6	0.5	0.7	0.5	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.2	0.4	-0.5	-0.3	-0.5	-0.4	0.4
Total zone transitions, hab. session 1	0.5	0.8	0.8	-0.8	0.9	0.9	0.8	0.9	-0.9
Total locomotion distance, hab. session 1	3.0	4.3	4.8	-2.1	2.2	2.1	2.0	2.0	-2.1
Locomotion velocity, hab. session 1	1.2	1.7	2.0	-1.4	1.4	1.3	1.2	1.3	-1.3
Time in familiar zone, hab. session 2	0.3	0.4	0.6	-0.7	0.8	0.5	0.6	0.5	-0.5
Time in novel zone, hab. session 2	0.6	0.6	0.7	0.8	-0.8	-0.7	-0.8	-0.7	0.7
Total zone transitions, hab. session 2	0.0	0.1	0.2	0.3	-0.4	-0.0	-0.2	-0.2	0.2
Total locomotion distance, hab. session 2	0.3	0.5	0.6	-0.7	0.6	0.8	0.6	0.7	-0.7
Locomotion velocity, hab. session 2	0.3	0.4	0.6	-0.6	0.5	0.7	0.6	0.6	-0.6
Novel to familiar place preference ratio	1.4	1.5	1.7	-1.1	1.2	1.2	1.3	1.3	-1.3
Novelty place preference	1.3	1.3	1.5	-1.0	1.1	1.1	1.2	1.2	-1.2
Time in novel zone, NPP test	0.8	0.8	0.9	-0.8	0.8	0.9	1.0	1.0	-1.0
Total zone transitions, NPP test	0.1	0.2	0.2	0.5	-0.4	-0.4	-0.4	-0.4	0.4
Total locomotion distance, NPP test	1.6	2.2	2.6	-1.6	1.6	1.4	1.4	1.4	-1.4
Locomotion velocity, NPP test	2.1	2.9	3.4	-1.8	1.8	1.7	1.7	1.6	-1.6
Intraocular pressure	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.2	-0.1	0.2
Delta distance traveled before/after self-admin	0.6	0.7	1.3	-0.9	1.1	0.6	0.6	0.8	-0.8
Delta ambulatory time before/after self-admin	1.3	1.4	1.9	-1.2	1.4	1.0	1.0	1.2	-1.2
Parametrial fat weight	0.5	1.1	1.2	1.1	-1.1	-1.0	-1.0	-1.0	1.0
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.3	-0.4	-0.5	-0.5	-0.5	0.5
Pavlov. Cond. magazine entry latency	0.2	0.2	0.2	0.4	-0.5	-0.4	-0.5	-0.5	0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1	0.0	-0.0
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	-0.0	0.1	0.1	0.1	-0.1
Pavlov. Cond. latency score	0.0	0.1	0.1	-0.1	0.2	0.3	0.3	0.2	-0.2
Pavlov. Cond. lever contacts	0.8	1.0	1.1	-0.9	1.0	1.0	1.0	1.0	-1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	0.4	0.2	0.3	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.4	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.2	0.1	0.4	0.3	0.3	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.1	-0.3	0.2	0.3	0.3	0.3	-0.3
Pavlov. Cond. lever latency	3.1	4.1	4.8	2.2	-2.1	-2.0	-2.1	-1.9	1.9
Pavlov. Cond. magazine entry latency	1.6	1.9	2.3	-1.5	1.5	1.3	1.3	1.3	-1.3
Pavlov. Cond. change in total contacts	5.8	8.0	9.4	-3.1	2.9	2.8	2.8	2.7	-2.6
Pavlov. Cond. index score	2.7	3.4	4.1	-2.0	2.0	1.8	1.8	1.7	-1.7
Pavlov. Cond. latency score	2.6	3.2	3.7	-1.9	1.9	1.7	1.8	1.7	-1.6
Pavlov. Cond. lever contacts	2.8	3.9	4.6	-2.1	2.0	2.0	2.0	1.9	-1.8
Pavlov. Cond. magazine entry number	1.0	1.2	1.7	1.2	-1.3	-1.0	-1.0	-1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.9	1.2	1.6	1.1	-1.3	-0.9	-1.0	-1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	3.1	4.0	4.6	-2.1	2.1	2.0	2.0	1.9	-1.9
Pavlov. Cond. response bias	3.2	4.4	5.1	-2.3	2.2	2.1	2.1	2.0	-2.0
Time in closed arm before self-admin	0.2	0.3	0.7	0.3	-0.8	-0.2	-0.4	-0.4	0.6
Time in closed arm after self-admin	0.1	0.1	0.2	-0.4	0.4	0.3	0.1	0.3	-0.3
Time in open arm before self-admin	1.6	1.7	2.2	-1.2	1.5	1.2	1.3	1.3	-1.4
Time in open arm after self-admin	1.2	1.3	1.9	-1.0	0.8	1.2	1.4	1.2	-1.2
Bone: periosteal estimation	2.2	4.5	4.7	-2.2	2.1	2.1	2.2	2.1	-2.1
Bone: periosteal perimeter	1.9	3.1	3.3	-1.8	1.8	1.7	1.7	1.7	-1.7
Bone: post-yield work	0.6	0.9	1.1	-1.0	1.1	0.9	0.8	0.9	-0.9
Progressive ratio test 1 active lever presses	1.4	1.4	1.8	-1.2	0.7	1.3	1.3	1.2	-1.2
Progressive ratio test 1 breakpoint	1.9	1.9	2.4	-1.5	0.9	1.6	1.5	1.4	-1.3
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.8	-0.6	0.9	0.5	0.6	0.4	-0.4
Progressive ratio test 2 active lever presses	0.5	0.5	0.6	-0.8	0.7	0.8	0.7	0.7	-0.6
Progressive ratio test 2 breakpoint	0.5	0.6	0.7	-0.8	0.7	0.8	0.8	0.8	-0.6
Progressive ratio test 2 inactive lever presses	2.6	2.9	3.4	-1.8	1.8	1.7	1.7	1.6	-1.6
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.0	0.3	-0.0	-0.1	0.0	0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.2	0.2	-0.2	-0.3	-0.1	0.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.2	0.1	0.2	0.1	0.1	-0.3
Progressive ratio	0.4	0.4	0.6	0.7	-0.3	-0.8	-0.7	-0.6	0.7
Food seeking constrained by brief footshock	2.8	3.4	3.9	-2.0	1.9	1.9	1.8	1.8	-1.7
Seeking ratio, punishment vs. effort	1.7	2.0	2.7	-1.6	1.0	1.6	1.5	1.4	-1.4
Retroperitoneal fat weight	0.9	2.9	3.6	1.9	-1.8	-1.6	-1.6	-1.7	1.5
Reaction time number correct	0.0	0.1	0.1	-0.1	0.0	0.3	0.3	0.3	-0.2
Reaction time mean minus median	0.1	0.2	0.3	-0.5	0.4	0.5	0.3	0.4	-0.3
Reaction time mean minus median AUC	0.2	0.3	0.5	-0.6	0.5	0.7	0.4	0.6	-0.5
Reaction time num false alarms	0.8	1.1	1.4	1.2	-1.0	-1.1	-1.1	-0.9	0.9
Reaction time num false alarms AUC	1.2	1.6	1.9	1.4	-1.3	-1.3	-1.3	-1.1	1.2
Reaction time trials correct on left	0.0	0.1	0.1	-0.1	0.0	0.3	0.3	0.3	-0.2
Reaction time trials on left	0.0	0.0	0.1	-0.1	-0.0	0.3	0.3	0.2	-0.1
Reaction time mean	0.1	0.1	0.2	0.3	-0.4	-0.3	-0.4	-0.3	0.4
Reaction time mean AUC	0.2	0.3	0.4	0.5	-0.6	-0.4	-0.6	-0.5	0.6
Median of all reaction times	0.2	0.3	0.4	0.5	-0.6	-0.5	-0.6	-0.5	0.6
Reaction time omissions	0.2	0.3	0.4	0.5	-0.6	-0.5	-0.4	-0.5	0.5
Reaction time false alarm rate	1.1	1.5	1.8	1.3	-1.1	-1.3	-1.4	-1.2	1.1
Reaction time premature initiation rate	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.0	-0.1	0.1
Reaction time premature initiations	0.0	0.0	0.0	-0.1	0.0	0.1	0.1	0.0	0.1
Std. dev. reaction times	0.0	0.1	0.1	-0.3	0.1	0.4	0.1	0.2	-0.1
Reaction time trials completed	0.0	0.0	0.1	-0.1	-0.0	0.3	0.3	0.2	-0.1
Reaction time trials AUC	0.0	0.0	0.0	0.0	-0.2	0.2	0.2	0.1	-0.0
Run reversals in cocaine runway, females	0.3	0.3	0.4	0.5	-0.5	-0.6	-0.6	-0.7	0.5
Run reversals in cocaine runway, males	1.2	1.2	2.3	1.0	-1.5	-0.9	-0.8	-1.1	1.2
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.2	0.0	-0.2	-0.3	-0.2	0.1
Latency to leave start box in cocaine runway, F	0.4	0.5	0.7	0.7	-0.6	-0.7	-0.8	-0.7	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.3	0.4	0.2	0.2	0.3	-0.4
Std. dev. time between licks in bursts	0.7	0.9	1.1	-0.9	1.1	0.8	0.8	1.0	-0.9
Total sessions with >9 infusions	0.0	0.0	0.2	0.3	-0.4	-0.0	-0.1	0.0	0.1
Short access day 1 total inactive lever presses	0.4	0.4	0.9	-0.7	0.9	0.6	0.6	0.5	-0.4
Short access day 10 total inactive lever presses	0.2	0.2	0.7	-0.5	0.8	0.3	0.3	0.2	-0.4
Short access day 1 total infusions	0.2	0.3	0.5	-0.5	0.0	0.6	0.7	0.5	-0.3
Short access day 10 total infusions	0.2	0.2	0.5	0.4	-0.6	-0.3	-0.4	-0.5	0.7
Short access total infusions	0.2	0.3	0.5	0.5	-0.7	-0.3	-0.3	-0.5	0.6
Short access day 1 locomotion	1.1	1.2	1.7	1.3	-1.0	-1.1	-1.1	-1.0	1.0
Short access day 10 total locomotion	0.4	0.5	0.9	-0.5	0.9	0.6	0.5	0.7	-0.8
Short access total locomotion	0.1	0.1	0.3	0.5	-0.1	-0.3	-0.4	-0.2	0.2
One hour access (0.3 mA shock)	1.2	1.4	2.0	-1.2	1.4	1.1	1.1	1.1	-1.0
Compulsive drug intake	0.3	0.3	0.4	-0.6	0.6	0.5	0.6	0.6	-0.5
One hour access (shock baseline)	0.1	0.2	0.3	-0.4	0.5	0.4	0.4	0.4	-0.3
Social response proportion	4.3	4.7	5.1	-2.2	2.0	2.2	2.3	2.1	-2.1
Social responses	0.1	0.1	0.2	-0.3	0.3	0.2	0.4	0.3	-0.2
Social time	0.4	0.5	0.7	-0.9	0.8	0.7	0.8	0.6	-0.5
Soleus weight	0.9	2.6	2.9	1.6	-1.5	-1.7	-1.7	-1.6	1.6
Bone: stiffness	1.4	2.2	2.4	-1.5	1.5	1.5	1.4	1.5	-1.5
Tibialis anterior weight	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	-0.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.1	0.4	0.4	0.4	0.3	-0.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.5	0.2	0.4	0.4	0.4	-0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.0	0.1	0.2	0.1	0.4	-0.5
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.0	0.3	0.1	-0.0	0.0	-0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	0.0	0.3	0.3	0.4	-0.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	0.1	-0.0	-0.0	-0.2	0.3
Tibia length	2.1	5.9	6.1	-2.4	2.4	2.4	2.5	2.4	-2.4
Ambulatory time before self-admin	0.9	0.9	1.3	-1.1	0.8	1.1	1.1	0.8	-0.8
Ambulatory time after self-admin	5.4	5.9	6.8	-2.6	2.6	2.5	2.4	2.3	-2.3
Bone: tissue strength	4.5	4.4	4.5	-2.1	2.1	2.1	2.1	2.1	-2.1
Total heroin consumption	1.5	1.8	2.1	-1.4	1.3	1.4	1.3	1.2	-1.3
Bone: trabecular number	0.1	0.2	0.2	-0.3	0.5	0.3	0.4	0.4	-0.5
Bone: trabecular spacing	1.7	2.2	2.4	-1.5	1.5	1.5	1.5	1.5	-1.4
Bone: trabecular thickness	0.2	0.2	0.3	0.5	-0.5	-0.4	-0.3	-0.4	0.4
Bone: trabecular tissue density	2.5	3.5	3.8	1.9	-1.9	-1.9	-1.8	-1.8	1.9
Water consumed over 24 hours	0.9	1.1	1.4	-0.9	0.9	1.0	1.1	1.1	-1.2
Number of responses in last shaping day	2.6	2.7	3.1	-1.6	1.3	1.7	1.8	1.7	-1.7