Hub : Genes

Spink8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Spink8	0.06	0.05	3.8e-03	0.07	0.04	0.05	0.06	6.2e-04	6.3e-03	3.2e-03	1.6e-03
2	IC	intron excision ratio	chr8_118700971_118702399	0.09	0.08	7.5e-03	0.02	-0.01	0	0.01	6.0e-02	8.3e-01	3.2e-01	1.7e-01
3	OFC	gene expression	Spink8	0.27	0.15	2.5e-03	0.12	0.08	0.14	0.12	1.1e-03	4.9e-03	2.7e-04	1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.3	0.6	1.8	-0.0	-0.0	1.3
Area under the delay curve	1.9	2.2	2.6	1.5	-1.4	1.6
BMI with tail	0.1	0.3	0.7	-0.8	0.3	-0.4
BMI without tail	0.4	1.3	2.4	-1.5	1.2	-0.2
Body weight	4.1	18.1	25.4	-5.0	4.4	-3.1
Weight adjusted by age	0.3	0.4	1.3	0.0	-0.0	-1.1
Bone surface	0.2	0.4	0.7	0.5	-0.7	0.8
Bone volume	0.2	0.4	1.1	0.3	-0.4	1.1
Breakpoint value in progressive ratio session	0.2	0.2	0.3	0.4	-0.3	0.6
Number of licking bursts	0.3	0.6	0.9	0.7	-0.5	-1.0
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	-0.2	-0.2
Locomotion velocity, session 1	0.1	0.1	0.2	0.2	-0.2	0.4
Locomotion distance, session 1	0.6	0.7	1.4	-1.2	0.9	0.1
Locomotion velocity, session 2	0.3	0.3	0.6	0.5	-0.8	0.1
Locomotion distance, session 2	0.2	0.3	0.7	0.0	-0.4	0.9
Locomotion velocity, session 3	0.5	0.5	1.4	-0.5	0.1	1.2
Locomotion distance, session 3	1.4	1.5	2.5	0.8	-1.1	1.6
Stereotopy head waving bouts, day 3	0.8	0.9	2.7	-0.1	0.1	-1.6
Stereotopy head waving duration, day 3	0.6	0.7	1.7	-0.3	0.5	-1.3
Locomotion velocity, session 7	0.4	0.4	1.1	-0.3	0.3	1.1
Locomotion distance, session 7	1.2	1.5	2.4	1.0	-1.1	1.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.0	-0.0	0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.6	0.6	-0.2
Locomotion velocity, session 8	0.2	0.2	0.4	-0.6	0.3	0.5
Locomotion distance, session 8	0.3	0.5	1.2	-0.5	0.0	1.1
Degree of sensitization distance	1.0	1.0	1.4	-1.0	1.2	-0.8
Degree of sensitization stereotypy	0.1	0.2	0.4	-0.2	0.2	0.6
Conditioned locomotion	3.0	3.5	3.8	1.9	-1.8	1.8
Cocaine response after cond. corrected	1.1	1.3	3.6	-0.4	0.5	-1.9
Cocaine response after cond. not corrected	2.1	2.5	3.9	-1.3	1.3	-2.0
Cocaine response before conditioning	0.8	1.0	1.7	-1.3	1.1	0.3
Saline control response	0.6	0.8	1.2	-0.9	1.1	0.5
Bone: connectivity density	0.8	1.3	3.2	0.7	-0.6	1.8
Bone: cortical apparent density	0.2	0.3	0.5	0.4	-0.5	0.7
Bone: cortical area	0.5	0.8	1.5	0.6	-0.7	-1.2
Bone: cortical porosity	0.9	1.0	2.6	0.4	-0.3	1.6
Bone: cortical porosity	0.9	0.9	2.6	0.4	-0.2	1.6
Bone: cortical thickness	0.7	1.2	3.5	-0.2	0.0	-1.9
Bone: cortical thickness	0.0	0.0	0.1	0.1	-0.1	-0.3
Bone: cortical tissue density	0.2	0.3	0.5	0.4	-0.5	0.7
Condit. Reinf. active minus inactive responses	0.5	0.5	1.3	-0.2	0.4	-1.1
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.3	-0.4	0.7	-1.5
Condit. Reinf. active responses	0.1	0.1	0.4	0.1	-0.1	-0.6
Condit. Reinf. inactive responses	0.6	0.7	0.9	0.8	-1.0	0.8
Incentive salience index mean	0.1	0.1	0.2	0.2	-0.2	-0.5
Condit. Reinf. lever presses	1.1	1.6	2.2	1.3	-1.5	0.8
Condit. Reinf. active minus inactive responses	1.4	1.9	2.5	-1.6	1.4	-1.1
Condit. Reinf. active-inactive response ratio	1.4	1.7	2.1	-1.4	1.3	-1.2
Condit. Reinf. active responses	1.3	1.8	2.4	-1.5	1.5	-1.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.3	-0.2	0.1
Condit. Reinf. lever presses	1.9	2.7	3.7	-1.9	1.7	-1.2
Condit. Reinf. lever reinforcers received	1.6	2.2	2.7	-1.7	1.6	-1.1
Conditioned reinforcement - actives	1.4	2.3	3.4	1.8	-1.8	0.6
Conditioned reinforcement - inactives	1.5	2.1	3.4	1.6	-1.8	-0.7
Conditioned locomotion	0.4	0.5	1.0	0.6	-0.5	1.0
Patch foraging indifference point 0 sec	0.7	1.3	2.0	-1.4	1.4	0.1
Patch foraging indifference point AUC	0.2	0.2	0.7	-0.2	0.1	0.8
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.0	-0.1	0.2
Delay disc. indifference point, 16s delay	1.0	1.1	1.3	1.0	-1.0	1.1
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	0.6	-0.5	0.5
Delay disc. indifference point, 24s delay	1.0	1.1	1.3	1.1	-1.0	1.2
Delay disc. indifference point, 4s delay	1.5	1.6	2.1	1.4	-1.3	0.9
Delay disc. indifference point, 8s delay	2.0	2.4	2.5	1.5	-1.5	1.6
Indifference point function ln k	0.2	0.3	0.5	0.5	-0.7	0.4
Indifference point function log k	0.2	0.3	0.5	0.5	-0.7	0.4
Patch foraging total patch changes 0 sec	0.8	1.4	2.2	-1.4	1.5	-0.2
Patch foraging total patch changes 12 sec	0.7	0.9	1.3	-1.1	1.2	-0.4
Patch foraging total patch changes 18 sec	1.3	2.0	3.4	-1.6	1.8	-0.1
Patch foraging total patch changes 24 sec	1.6	2.8	3.8	-1.9	1.9	-1.0
Patch foraging total patch changes 6 sec	0.3	0.4	0.6	-0.5	0.6	0.8
Patch foraging time to switch 0 sec	0.2	0.3	0.6	0.5	-0.4	-0.7
Patch foraging water rate 0 sec	0.1	0.2	0.3	-0.5	0.5	-0.3
Patch foraging water rate 12 sec	0.1	0.3	0.4	-0.6	0.6	-0.4
Patch foraging water rate 18 sec	0.2	0.2	0.6	-0.3	0.1	-0.8
Patch foraging water rate 24 sec	0.8	1.1	1.1	-1.0	1.1	-1.0
Patch foraging water rate 6 sec	0.3	0.5	0.8	-0.9	0.8	0.0
Seeking ratio, delayed vs. immediate footshock	2.3	2.8	3.0	1.6	-1.7	1.7
Distance traveled before self-admin	0.3	0.4	0.5	0.7	-0.6	-0.6
Distance traveled after self-admin	0.2	0.3	0.5	0.7	-0.5	-0.2
Extensor digitorum longus weight	0.1	0.3	0.6	0.7	-0.7	0.1
Bone: elastic displacement	0.2	0.3	0.7	-0.2	0.3	-0.8
Bone: elastic work	0.4	0.6	1.0	-0.6	0.5	-1.0
Bone: endosteal estimation	0.1	0.2	0.5	-0.1	0.2	0.7
Bone: endosteal perimeter	1.0	2.1	2.8	1.6	-1.7	1.0
Epididymis fat weight	0.3	1.1	1.5	-1.2	1.1	-0.7
Delta time in closed arm before/after self-admin	0.7	0.6	0.9	0.7	-0.7	1.0
Delta time in open arm before/after self-admin	0.3	0.3	0.4	-0.6	0.6	-0.5
Diff in mean of infusions in LGA sessions	0.9	1.1	3.2	0.0	0.1	-1.8
Delay discount exponential model param	2.1	2.4	2.6	-1.5	1.5	-1.6
Extinction: sum of active levers before priming	0.2	0.3	0.6	0.4	-0.2	0.8
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.2	0.3	0.7
Bone: final force	1.3	2.0	3.4	-1.2	1.1	-1.9
Bone: final moment	1.6	2.5	4.4	-1.4	1.2	-2.1
Food consumed during 24 hour testing period	1.2	1.7	2.2	-1.5	1.3	-1.1
Glucose	0.8	1.3	2.0	-1.4	1.3	0.4
Heart weight	2.8	4.3	8.2	-1.6	1.5	-2.9
Delay discount hyperbolic model param	2.3	2.5	2.7	-1.6	1.6	-1.6
Intermittent access intake day 1-15 change	0.5	1.0	1.7	1.2	-1.3	-0.3
Intermittent access intake escalation	0.7	1.5	2.4	1.4	-1.6	-0.3
Intermittent access intake escalation 2	0.4	0.4	0.9	0.4	-0.5	-1.0
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.7	0.2	-0.3	-0.8
Intermitt. access day 15 inactive lever presses	0.8	1.7	2.4	1.5	-1.5	-0.6
Intermitt. access escalation Index	0.3	0.4	1.1	0.2	-0.1	1.0
Intermittent access day 1 total infusions	0.3	0.4	0.7	0.9	-0.8	0.1
Intermittent access day 15 total infusions	1.4	2.1	3.3	1.7	-1.8	-0.0
Intermittent access terminal intake (last 3 days)	1.2	1.5	2.4	1.5	-1.5	0.2
Intermittent access total infusions	1.7	2.0	3.0	1.7	-1.7	0.1
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.1	0.2	0.2
Intermittent access day 15 total locomotion	0.4	0.7	0.8	0.8	-0.9	0.7
Intermittent access total locomotion	1.0	1.2	1.4	1.1	-1.2	1.0
Intermittent access standard deviation	0.6	1.2	3.6	0.0	-0.2	-1.9
Left kidney weight	0.5	2.4	3.8	-2.0	1.7	-0.6
Right kidney weight	0.2	0.9	1.5	-1.2	1.2	-0.0
Cocaine induced anxiety	0.2	0.3	0.9	-0.2	0.2	-1.0
Post-drug Anxiety	0.0	0.0	0.1	0.0	-0.0	-0.4
Baseline Anxiety	0.4	0.4	1.0	0.4	-0.4	1.0
Tail length	3.9	15.4	20.3	-4.5	4.5	-2.4
Length with tail	7.7	33.6	41.5	-6.4	6.3	-4.5
Length without tail	6.3	20.4	24.3	-4.9	4.7	-3.8
Times rat made contact with spout	0.7	0.8	0.9	-0.9	0.8	-0.9
Lifetime Intake	1.8	2.2	3.2	1.7	-1.8	0.6
Liver weight, left	0.5	0.8	1.4	-1.1	1.2	0.1
Liver weight, right	1.1	1.9	2.8	-1.6	1.7	-0.3
Locomotor activity	4.5	7.1	9.7	-2.9	3.1	-1.8
Locomotor testing distance	3.3	5.9	8.2	-2.6	2.9	-1.6
Locomotor testing rearing	0.0	0.1	0.1	0.1	0.3	-0.3
Locomotion in novel chamber	0.2	0.2	0.6	0.3	-0.3	-0.8
Locomotion in novel chamber post-restriction	0.3	0.6	0.9	-0.8	0.9	0.4
Fecal boli incidents, locomotor time 1	0.3	0.4	0.7	-0.5	0.6	-0.8
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.0	-0.2	0.3
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.4	0.3	-0.2	1.2
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.2	0.2	-0.2
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.1	0.1	-0.1
Rest time, locomotor task time 1	0.7	0.8	0.9	0.9	-0.8	1.0
Distance moved, locomotor task time 1	1.3	2.0	2.2	-1.4	1.3	-1.5
Vertical activity count, locomotor time 1	0.4	1.0	1.3	-1.2	1.0	-0.8
Time >=10cm from walls, locomotor time 2	0.8	1.2	1.7	-1.3	1.3	-0.4
Bouts of movement, locomotor time 2	0.2	0.3	0.7	0.2	-0.1	-0.8
Total resting periods, locomotor time 2	0.1	0.2	0.3	0.4	-0.4	-0.5
Rest time, locomotor task time 2	0.2	0.2	0.3	0.4	-0.3	0.6
Distance moved, locomotor task time 2	1.3	1.5	1.8	-1.4	1.1	-1.2
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.4	0.2	-0.2
Light reinforcement 1	0.4	0.9	1.3	-1.1	1.0	-0.7
Light reinforcement 2	0.4	0.7	1.9	0.1	-0.4	1.4
Bone: marrow area	0.1	0.2	0.5	-0.1	0.2	0.7
Bone: maximum diameter	0.4	0.8	0.9	0.9	-1.0	-0.7
Bone: maximum force	0.5	0.9	1.0	-1.0	0.9	-1.0
Bone: maximum moment	0.6	1.1	1.4	-1.0	0.9	-1.2
Mean time between licks in bursts	0.6	1.5	2.0	1.4	-1.4	0.6
Mean num. licks in bursts	0.6	0.9	1.4	-1.2	1.0	0.5
Cd content in liver	0.1	0.2	0.4	0.2	-0.2	0.6
Co content in liver	1.1	1.3	2.0	1.4	-1.3	-0.5
Cu content in liver	3.3	4.0	5.2	-2.2	2.3	-1.3
Fe content in liver	1.5	1.9	2.7	-1.0	1.4	-1.6
K content in liver	0.2	0.1	0.3	-0.5	0.3	-0.3
Mg content in liver	0.8	0.8	1.6	0.8	-1.2	0.4
Mn content in liver	0.1	0.1	0.2	-0.3	-0.2	0.5
Na content in liver	0.5	0.6	0.9	-0.6	0.9	-0.7
Rb content in liver	0.8	0.9	1.7	-0.4	1.0	-1.3
Se content in liver	0.1	0.1	0.2	-0.4	0.2	-0.2
Sr content in liver	0.2	0.2	0.2	-0.3	-0.4	0.5
Zn content in liver	1.7	1.8	2.7	-1.6	1.5	-0.6
Bone: minimum diameter	0.5	1.0	1.6	1.1	-1.2	0.4
Time in familiar zone, hab. session 1	1.0	0.9	1.8	1.3	-1.0	-0.1
Time in novel zone, hab. session 1	0.6	0.6	1.0	-1.0	0.9	-0.4
Total zone transitions, hab. session 1	0.4	0.5	1.0	-1.0	0.7	0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.6	-0.8	0.6	0.2
Locomotion velocity, hab. session 1	0.3	0.4	0.7	-0.8	0.6	0.4
Time in familiar zone, hab. session 2	0.7	0.7	1.0	1.0	-0.9	-0.6
Time in novel zone, hab. session 2	0.2	0.2	0.4	-0.2	0.3	0.6
Total zone transitions, hab. session 2	0.0	0.1	0.2	-0.4	-0.0	0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.8	-0.9	0.7	0.2
Locomotion velocity, hab. session 2	0.3	0.3	0.6	-0.8	0.6	0.3
Novel to familiar place preference ratio	1.5	1.6	3.1	-0.9	1.0	1.8
Novelty place preference	1.6	1.8	3.5	-0.9	1.0	1.9
Time in novel zone, NPP test	1.5	1.6	2.5	-1.0	1.1	1.6
Total zone transitions, NPP test	1.5	2.2	4.5	-2.1	1.5	0.1
Total locomotion distance, NPP test	0.9	1.2	2.2	-1.5	1.2	-0.2
Locomotion velocity, NPP test	0.9	1.3	2.3	-1.5	1.2	-0.0
Intraocular pressure	0.7	1.0	1.9	-1.1	1.4	-0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	0.3	0.2
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	-0.8	0.9	-0.1
Parametrial fat weight	0.9	2.2	3.4	-1.8	1.6	-0.9
Pavlov. Cond. lever latency	3.0	3.7	5.3	-2.2	2.3	-1.1
Pavlov. Cond. magazine entry latency	5.6	7.2	10.3	3.2	-3.2	1.1
Pavlov. Cond. change in total contacts	1.1	1.1	1.9	1.4	-1.2	-0.0
Pavlov. Cond. index score	4.5	5.6	8.2	2.8	-2.9	0.8
Pavlov. Cond. latency score	4.4	5.5	8.0	2.8	-2.8	1.0
Pavlov. Cond. lever contacts	1.6	1.9	2.9	1.6	-1.7	0.7
Pavlov. Cond. magazine entry number	5.6	7.0	10.3	-3.2	3.2	-0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	-0.6	0.7	-0.2
Pavlov. Cond. lever-magazine prob. diff.	3.9	4.9	7.2	2.7	-2.7	0.5
Pavlov. Cond. response bias	4.8	5.9	8.7	2.9	-3.0	0.8
Pavlov. Cond. lever latency	0.4	0.5	0.8	0.9	-0.7	0.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.3	-0.5	0.1
Pavlov. Cond. change in total contacts	1.8	3.0	3.3	-1.8	1.7	-1.6
Pavlov. Cond. index score	0.2	0.2	0.3	-0.5	0.3	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.4	0.2	-0.4
Pavlov. Cond. lever contacts	0.5	0.7	1.2	-1.1	0.9	-0.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.4	0.6	-0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.2	1.1	-0.8	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.4	0.2	-0.5
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.3	0.1	-0.3
Time in closed arm before self-admin	0.8	1.0	1.2	-1.1	1.0	-0.9
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	-0.4	-0.1
Time in open arm before self-admin	0.9	1.0	1.4	1.2	-1.0	0.8
Time in open arm after self-admin	1.0	1.1	2.8	0.5	-0.5	1.7
Bone: periosteal estimation	0.0	0.1	0.1	0.2	-0.2	-0.3
Bone: periosteal perimeter	0.8	1.5	2.2	1.4	-1.5	0.4
Bone: post-yield work	0.1	0.1	0.2	-0.0	-0.0	0.5
Progressive ratio test 1 active lever presses	0.2	0.2	0.4	0.3	-0.2	0.7
Progressive ratio test 1 breakpoint	0.2	0.2	0.5	0.3	-0.3	0.7
Progressive ratio test 1 inactive lever presses	0.4	0.6	0.7	0.9	-0.9	-0.6
Progressive ratio test 2 active lever presses	1.5	1.8	2.8	1.6	-1.7	0.4
Progressive ratio test 2 breakpoint	1.6	1.8	2.8	1.6	-1.7	0.3
Progressive ratio test 2 inactive lever presses	2.0	3.3	4.7	2.2	-2.1	-0.8
Incentive Sensitization - Responses	1.4	2.0	3.3	1.7	-1.8	-0.1
Incentive Sensitization - Breakpoint	1.6	2.1	3.4	1.7	-1.8	-0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	0.0	0.2	0.9
Progressive ratio	1.7	2.6	3.9	-1.9	2.0	-0.5
Food seeking constrained by brief footshock	0.7	0.8	0.9	0.9	-1.0	0.8
Seeking ratio, punishment vs. effort	2.8	4.1	6.0	2.3	-2.5	0.9
Retroperitoneal fat weight	1.5	6.2	8.8	-3.0	2.7	-1.5
Reaction time number correct	0.2	0.3	0.6	0.8	-0.5	0.2
Reaction time mean minus median	0.0	0.0	0.1	-0.3	0.1	0.2
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.5	0.3	0.3
Reaction time num false alarms	0.3	0.5	0.7	0.8	-0.8	0.4
Reaction time num false alarms AUC	0.1	0.2	0.2	0.5	-0.4	0.4
Reaction time trials correct on left	0.2	0.3	0.6	0.8	-0.5	0.2
Reaction time trials on left	0.2	0.3	0.7	0.8	-0.5	0.3
Reaction time mean	0.0	0.0	0.1	-0.0	0.0	0.3
Reaction time mean AUC	0.1	0.1	0.4	0.1	-0.0	0.6
Median of all reaction times	0.0	0.1	0.1	0.2	-0.1	0.4
Reaction time omissions	0.1	0.2	0.4	0.4	-0.2	0.6
Reaction time false alarm rate	0.0	0.1	0.1	0.2	-0.3	0.2
Reaction time premature initiation rate	1.8	2.5	3.3	-1.8	1.8	-1.1
Reaction time premature initiations	0.8	1.5	1.8	-1.3	1.3	-1.0
Std. dev. reaction times	0.1	0.2	0.3	-0.4	0.3	0.6
Reaction time trials completed	0.2	0.3	0.7	0.8	-0.5	0.3
Reaction time trials AUC	0.2	0.5	0.9	0.9	-0.6	0.3
Run reversals in cocaine runway, females	0.6	0.6	0.9	1.0	-0.9	0.4
Run reversals in cocaine runway, males	1.8	1.8	3.1	-1.1	1.0	-1.8
Latency to leave start box in cocaine runway	0.4	0.4	0.5	-0.7	0.6	-0.7
Latency to leave start box in cocaine runway, F	1.7	1.9	3.5	-1.1	1.0	-1.9
Latency to leave start box in cocaine runway, M	0.8	0.8	1.1	0.8	-0.7	1.0
Std. dev. time between licks in bursts	3.2	4.4	6.7	2.6	-2.5	0.1
Total sessions with >9 infusions	0.3	0.4	0.6	0.7	-0.8	-0.4
Short access day 1 total inactive lever presses	3.2	4.2	5.4	2.3	-2.3	1.3
Short access day 10 total inactive lever presses	0.6	1.6	4.5	-0.4	0.3	-2.1
Short access day 1 total infusions	2.6	3.4	4.3	2.1	-2.1	1.2
Short access day 10 total infusions	2.0	2.6	3.2	1.8	-1.8	1.2
Short access total infusions	3.1	4.0	4.7	2.1	-2.2	1.6
Short access day 1 locomotion	0.3	0.4	0.6	0.8	-0.8	0.1
Short access day 10 total locomotion	0.1	0.1	0.3	-0.2	0.3	0.6
Short access total locomotion	0.1	0.2	0.4	0.2	-0.1	0.6
One hour access (0.3 mA shock)	1.0	1.1	1.2	1.0	-1.1	1.1
Compulsive drug intake	1.5	1.8	3.6	0.9	-0.9	1.9
One hour access (shock baseline)	0.4	0.6	0.8	0.8	-0.9	-0.5
Social response proportion	0.2	0.3	0.5	-0.4	0.7	-0.4
Social responses	0.1	0.2	0.3	-0.5	0.6	-0.2
Social time	0.4	0.6	0.6	0.8	-0.8	-0.7
Soleus weight	3.2	9.5	12.4	-3.5	3.3	-2.3
Bone: stiffness	0.1	0.1	0.2	-0.4	0.3	-0.4
Tibialis anterior weight	0.1	0.2	0.4	-0.2	0.1	-0.7
Time to tail flick, vehicle, before self-admin	1.5	1.5	2.2	-1.5	1.4	-0.6
Time to tail flick, vehicle, after self-admin	0.7	1.0	2.0	-0.7	0.7	-1.4
Time to tail flick, test, before self-admin	0.4	0.4	1.3	-0.1	0.2	1.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.4
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.4	0.6	-0.6	-0.5
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.6	-0.5	-0.3
Tibia length	5.0	13.9	20.5	-4.5	4.0	-2.3
Ambulatory time before self-admin	0.5	0.8	1.1	1.1	-1.1	-0.2
Ambulatory time after self-admin	0.1	0.1	0.1	0.4	-0.3	0.1
Bone: tissue strength	3.0	3.0	3.2	-1.7	1.7	-1.8
Total heroin consumption	2.2	2.5	4.4	-1.1	1.4	-2.1
Bone: trabecular number	1.5	2.4	5.2	1.0	-1.0	2.3
Bone: trabecular spacing	2.5	3.3	6.4	-1.3	1.3	-2.5
Bone: trabecular thickness	0.6	0.7	1.9	-0.3	0.2	1.4
Bone: trabecular tissue density	0.3	0.4	0.7	-0.9	0.7	-0.3
Water consumed over 24 hours	0.4	0.6	1.7	-0.3	0.1	-1.3
Number of responses in last shaping day	0.9	1.0	1.7	0.8	-0.8	-1.3