Hub : Genes

Spindoc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	isoform ratio	NM_001399680.1	0.05	0.03	5.0e-03	0	0.01	-0	0	1.6e-01	9.2e-02	6.5e-01	1.7e-01
2	Adipose	mRNA stability	Spindoc	0.03	0.02	3.6e-03	0.02	0.01	0	0.01	1.7e-03	1.7e-02	8.8e-02	1.4e-02
3	BLA	gene expression	Spindoc	0.07	0.05	8.4e-03	0.01	0	0.01	0.01	8.7e-02	2.9e-01	1.1e-01	1.1e-01
4	NAcc	mRNA stability	Spindoc	0.03	0.02	3.7e-04	0.02	0.03	0.01	0.03	9.4e-04	5.8e-05	7.0e-03	6.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.2	2.3	2.7	1.6	-1.5	-1.5	-1.3
Area under the delay curve	0.2	0.3	0.6	0.4	-0.6	-0.5	-0.8
BMI with tail	6.1	21.2	22.9	4.6	-4.5	-4.5	-4.8
BMI without tail	0.7	3.8	5.5	2.1	-1.6	-1.7	-2.3
Body weight	3.9	17.2	23.6	4.7	-3.3	-3.5	-4.9
Weight adjusted by age	0.4	1.1	2.2	1.5	-0.7	-0.9	-1.0
Bone surface	4.3	8.5	14.6	3.8	-2.6	-2.5	-2.4
Bone volume	2.7	5.3	7.6	2.8	-2.4	-2.3	-1.7
Breakpoint value in progressive ratio session	0.6	1.1	3.3	1.8	-0.1	-0.1	-0.9
Number of licking bursts	0.0	0.1	0.3	0.5	-0.1	-0.3	-0.2
Context. condit. distance diff. score	0.2	0.2	0.6	-0.8	-0.3	-0.4	0.1
Locomotion velocity, session 1	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.3
Locomotion distance, session 1	1.0	1.3	1.8	0.9	-1.2	-1.0	-1.3
Locomotion velocity, session 2	1.6	1.9	3.0	1.7	-1.0	-0.8	-1.7
Locomotion distance, session 2	0.2	0.3	0.7	0.5	-0.3	-0.0	-0.8
Locomotion velocity, session 3	2.9	3.3	5.1	0.7	-2.3	-2.1	-1.8
Locomotion distance, session 3	0.2	0.2	0.5	0.1	-0.6	-0.3	-0.7
Stereotopy head waving bouts, day 3	1.3	1.5	2.7	0.2	-1.5	-1.7	-1.0
Stereotopy head waving duration, day 3	0.3	0.4	0.9	-0.2	-0.8	-0.9	-0.2
Locomotion velocity, session 7	0.8	0.9	2.3	0.1	-1.5	-1.0	-0.7
Locomotion distance, session 7	0.3	0.4	0.9	0.0	-0.9	-0.5	-0.8
Stereotopy head waving bouts, day 7	0.5	0.6	0.8	0.8	-0.9	-0.9	-0.2
Stereotopy head waving duration, day 7	0.9	1.2	2.2	1.5	-0.9	-0.9	-0.8
Locomotion velocity, session 8	0.3	0.4	1.0	0.3	0.5	1.0	-0.0
Locomotion distance, session 8	0.4	0.6	1.2	0.2	-1.1	-0.9	-0.4
Degree of sensitization distance	0.9	1.0	1.5	0.5	-1.2	-1.2	-0.9
Degree of sensitization stereotypy	0.7	0.8	1.6	1.3	-0.9	-0.8	-0.5
Conditioned locomotion	0.4	0.5	1.1	1.0	-0.2	-0.4	-0.9
Cocaine response after cond. corrected	0.2	0.3	1.1	-1.1	0.1	0.3	0.2
Cocaine response after cond. not corrected	0.1	0.1	0.5	-0.7	-0.2	0.1	0.0
Cocaine response before conditioning	0.2	0.3	0.9	1.0	-0.5	-0.2	-0.2
Saline control response	1.5	2.1	4.1	2.0	-0.8	-0.3	-1.9
Bone: connectivity density	3.1	4.9	7.1	2.7	-2.0	-2.0	-2.1
Bone: cortical apparent density	0.5	0.8	1.7	-0.5	1.3	1.0	0.6
Bone: cortical area	1.1	1.8	2.2	1.5	-1.3	-1.2	-1.3
Bone: cortical porosity	0.5	0.6	1.1	-0.2	0.8	1.1	0.7
Bone: cortical porosity	0.3	0.3	0.9	0.2	0.6	0.9	0.3
Bone: cortical thickness	0.5	0.9	1.5	1.0	0.6	0.7	-1.2
Bone: cortical thickness	0.3	0.3	0.6	-0.1	0.5	0.8	-0.6
Bone: cortical tissue density	0.5	0.8	1.9	-0.4	1.4	1.0	0.5
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	0.6	-0.4	-0.6	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.1	0.5	0.4	0.2
Condit. Reinf. active responses	0.8	1.0	1.7	0.7	-1.0	-1.3	-0.9
Condit. Reinf. inactive responses	0.8	1.1	2.2	0.5	-1.2	-1.5	-0.6
Incentive salience index mean	1.1	1.4	1.8	1.0	-1.0	-1.2	-1.3
Condit. Reinf. lever presses	1.6	2.3	2.6	1.4	-1.6	-1.6	-1.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.1	-0.6	-0.1	0.5
Condit. Reinf. active-inactive response ratio	0.4	0.7	1.2	0.2	-1.1	-1.1	0.5
Condit. Reinf. active responses	0.1	0.1	0.3	0.3	-0.5	-0.0	-0.1
Condit. Reinf. inactive responses	0.2	0.3	0.9	0.1	0.3	1.0	-0.5
Condit. Reinf. lever presses	1.5	2.2	3.8	1.9	-1.5	-1.1	-1.2
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	0.6	-0.5	-0.1	-0.2
Conditioned reinforcement - actives	0.1	0.2	0.5	0.5	-0.3	-0.2	0.7
Conditioned reinforcement - inactives	0.3	0.7	1.5	-0.3	-1.2	-1.1	0.5
Conditioned locomotion	1.4	2.0	5.3	-2.3	-0.3	-0.4	1.6
Patch foraging indifference point 0 sec	0.1	0.3	0.5	0.3	-0.7	-0.5	-0.6
Patch foraging indifference point AUC	0.4	0.9	2.8	1.7	-0.4	-0.3	-0.6
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.1	-0.4	-0.5	-0.5
Delay disc. indifference point, 16s delay	0.4	0.5	1.2	-0.1	-1.1	-0.9	-0.4
Delay disc. indifference point, 2s delay	0.3	0.3	0.5	0.4	-0.7	-0.7	-0.3
Delay disc. indifference point, 24s delay	0.0	0.1	0.2	-0.1	-0.2	-0.1	-0.5
Delay disc. indifference point, 4s delay	0.4	0.4	1.2	0.2	-0.4	-0.4	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	-0.2	0.4	0.6	0.0
Indifference point function ln k	1.1	3.2	9.6	-3.1	0.9	0.8	1.3
Indifference point function log k	1.1	3.2	9.6	-3.1	0.9	0.8	1.3
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	-0.0	-0.3	-0.1	-0.5
Patch foraging total patch changes 12 sec	2.2	2.9	5.7	2.4	-1.1	-0.6	-2.1
Patch foraging total patch changes 18 sec	0.1	0.3	1.0	1.0	-0.3	-0.1	-0.4
Patch foraging total patch changes 24 sec	1.2	4.1	6.4	2.1	-1.9	-1.4	-2.5
Patch foraging total patch changes 6 sec	0.9	1.5	2.4	1.3	-1.1	-0.8	-1.5
Patch foraging time to switch 0 sec	0.9	3.6	4.8	2.2	-2.0	-1.8	-1.4
Patch foraging water rate 0 sec	0.8	2.9	6.7	-2.6	1.3	1.1	1.4
Patch foraging water rate 12 sec	1.4	5.7	13.9	-3.7	1.7	1.6	1.8
Patch foraging water rate 18 sec	0.4	1.0	3.5	-1.9	0.6	0.2	0.2
Patch foraging water rate 24 sec	1.5	2.2	4.8	-2.2	1.0	1.1	1.3
Patch foraging water rate 6 sec	2.1	3.1	8.0	-2.8	1.3	1.3	1.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.4
Distance traveled before self-admin	1.1	2.5	2.9	1.7	-1.5	-1.6	-1.4
Distance traveled after self-admin	0.0	0.1	0.1	0.3	0.3	0.1	-0.1
Extensor digitorum longus weight	4.2	16.8	29.7	5.4	-2.5	-2.6	-4.9
Bone: elastic displacement	1.6	2.0	2.9	-1.7	1.5	1.4	0.9
Bone: elastic work	0.3	0.4	1.4	0.4	0.5	0.2	-1.2
Bone: endosteal estimation	1.5	3.6	7.3	0.8	-2.4	-2.7	-0.8
Bone: endosteal perimeter	1.4	3.5	7.1	0.8	-2.5	-2.7	-0.3
Epididymis fat weight	0.4	2.0	3.8	-1.0	-1.7	-1.9	0.4
Delta time in closed arm before/after self-admin	0.5	0.5	1.9	-0.1	-0.3	-0.3	-1.4
Delta time in open arm before/after self-admin	0.8	0.9	1.5	1.2	-1.0	-0.9	-0.6
Diff in mean of infusions in LGA sessions	0.2	0.4	1.1	0.6	-0.1	0.1	-1.0
Delay discount exponential model param	0.2	0.3	0.6	-0.4	0.6	0.5	0.8
Extinction: sum of active levers before priming	1.6	2.4	3.7	1.9	-1.1	-1.2	-1.8
Active lever presses in extinction session 6	1.8	1.8	4.6	2.1	-0.7	-1.0	-1.1
Bone: final force	2.6	4.2	6.3	2.5	-1.7	-1.8	-2.1
Bone: final moment	2.6	4.2	6.1	2.5	-1.7	-1.8	-2.1
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.2	-0.2	-0.0	0.3
Glucose	0.4	0.7	1.3	-0.8	-1.1	-0.9	0.2
Heart weight	0.6	1.0	1.4	0.1	-1.1	-1.2	-1.1
Delay discount hyperbolic model param	0.3	0.3	0.5	-0.5	0.6	0.5	0.7
Intermittent access intake day 1-15 change	0.2	0.9	2.7	-0.8	0.4	0.5	1.6
Intermittent access intake escalation	0.2	1.1	3.3	-0.7	0.6	0.6	1.8
Intermittent access intake escalation 2	0.2	0.4	1.3	-0.4	-0.1	-0.0	1.1
Intermitt. access day 1 inactive lever presses	0.1	1.0	2.3	-0.6	0.9	0.9	1.5
Intermitt. access day 15 inactive lever presses	0.4	2.0	4.0	0.1	-2.0	-1.9	-0.5
Intermitt. access escalation Index	0.4	1.3	3.2	-1.8	0.7	0.7	0.9
Intermittent access day 1 total infusions	1.1	3.3	6.5	0.2	-2.5	-2.5	-0.7
Intermittent access day 15 total infusions	0.5	1.3	1.8	-0.9	-1.1	-1.1	1.3
Intermittent access terminal intake (last 3 days)	1.4	2.5	5.1	0.0	-2.3	-2.2	0.2
Intermittent access total infusions	1.9	2.3	4.8	-0.1	-2.2	-2.1	0.0
Intermittent access day 1 locomotion	1.2	2.2	4.2	0.0	-2.0	-2.0	-0.7
Intermittent access day 15 total locomotion	0.5	1.9	3.8	-0.2	-1.9	-1.9	0.2
Intermittent access total locomotion	3.9	4.7	9.5	0.0	-3.1	-3.0	-0.3
Intermittent access standard deviation	0.1	0.4	0.9	-0.7	-0.3	-0.1	1.0
Left kidney weight	0.1	1.1	2.6	0.1	-1.4	-1.6	-0.3
Right kidney weight	0.1	0.7	1.4	-0.0	-1.1	-1.2	-0.2
Cocaine induced anxiety	0.0	0.0	0.1	0.3	0.2	0.1	0.3
Post-drug Anxiety	0.1	0.1	0.5	0.7	-0.1	-0.2	-0.3
Baseline Anxiety	0.1	0.2	0.6	0.1	-0.1	0.0	-0.8
Tail length	0.1	0.7	1.4	0.2	1.2	1.0	-0.4
Length with tail	0.5	2.1	4.3	2.1	0.1	-0.1	-2.1
Length without tail	0.7	3.7	8.4	2.3	-0.7	-0.9	-2.9
Times rat made contact with spout	0.3	0.3	0.6	0.0	0.8	0.8	-0.1
Lifetime Intake	1.2	1.5	3.1	-0.2	-1.8	-1.7	-0.1
Liver weight, left	0.3	0.5	1.2	-1.1	0.6	0.5	0.6
Liver weight, right	0.3	0.5	1.9	-1.4	0.0	-0.1	0.1
Locomotor activity	1.7	2.6	4.5	-2.1	1.5	1.5	1.2
Locomotor testing distance	0.9	2.2	4.7	-2.2	1.3	1.3	0.9
Locomotor testing rearing	0.4	1.6	3.9	-2.0	0.8	1.1	0.8
Locomotion in novel chamber	0.6	0.9	1.8	-1.3	-0.3	-0.6	1.1
Locomotion in novel chamber post-restriction	0.5	1.5	3.1	-1.6	0.4	0.4	1.8
Fecal boli incidents, locomotor time 1	0.1	0.3	0.4	0.6	-0.6	-0.3	0.5
Change in fecal boli incidents, locomotor task	0.4	0.4	0.8	-0.7	0.9	0.6	0.3
Time >=10cm from walls, locomotor time 1	0.5	0.7	1.0	0.4	-1.0	-1.0	0.7
Bouts of movement, locomotor time 1	1.4	1.8	3.8	-0.2	1.6	2.0	1.1
Total resting periods, locomotor time 1	1.0	1.1	2.4	-0.1	1.2	1.5	0.9
Rest time, locomotor task time 1	1.0	1.7	2.8	-1.5	0.9	1.0	1.7
Distance moved, locomotor task time 1	0.3	0.8	1.0	1.0	-0.7	-0.8	-1.0
Vertical activity count, locomotor time 1	0.0	0.1	0.4	-0.6	0.1	0.1	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.6	0.3	0.2	0.1	0.8
Bouts of movement, locomotor time 2	0.1	0.2	0.4	0.5	-0.3	-0.1	-0.6
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.3	-0.3	-0.0	-0.4
Rest time, locomotor task time 2	0.7	1.3	2.3	-1.5	0.4	0.7	1.4
Distance moved, locomotor task time 2	0.2	0.3	0.5	0.7	0.7	0.4	-0.2
Vertical activity count, locomotor time 2	0.4	1.0	2.1	-0.8	1.4	1.1	0.5
Light reinforcement 1	0.1	0.4	0.7	-0.6	0.4	0.8	0.7
Light reinforcement 2	0.4	0.9	1.8	-0.1	-1.2	-1.4	0.5
Bone: marrow area	1.3	3.3	6.8	0.7	-2.3	-2.6	-0.7
Bone: maximum diameter	1.2	2.4	3.2	1.6	-1.8	-1.8	-0.9
Bone: maximum force	5.1	10.0	12.5	3.5	-3.0	-3.0	-3.0
Bone: maximum moment	5.0	9.5	11.7	3.4	-3.0	-3.0	-3.0
Mean time between licks in bursts	0.1	0.4	0.7	-0.2	0.7	0.6	-0.8
Mean num. licks in bursts	0.2	0.6	0.8	-0.8	0.7	0.9	0.5
Cd content in liver	0.4	0.5	1.6	-0.5	-0.2	-0.1	1.3
Co content in liver	3.6	4.2	5.2	-2.2	2.1	2.3	1.5
Cu content in liver	0.2	0.3	0.4	-0.4	0.5	0.6	0.5
Fe content in liver	0.1	0.1	0.2	0.5	-0.2	-0.1	-0.1
K content in liver	1.2	1.2	2.0	1.0	-1.0	-0.8	-1.4
Mg content in liver	0.4	0.5	0.7	-0.1	-0.7	-0.7	-0.9
Mn content in liver	2.2	2.4	4.2	2.1	-1.3	-1.3	-1.5
Na content in liver	0.5	0.6	0.7	0.7	-0.8	-0.6	-0.9
Rb content in liver	1.2	1.4	2.9	-1.7	0.8	0.9	1.0
Se content in liver	0.4	0.5	1.1	0.4	-0.8	-1.0	0.0
Sr content in liver	1.1	0.9	1.9	1.4	-0.6	-0.4	-1.1
Zn content in liver	0.9	1.0	1.9	0.8	-0.9	-0.9	-1.4
Bone: minimum diameter	1.9	3.7	6.7	0.8	-2.6	-2.6	-0.9
Time in familiar zone, hab. session 1	0.3	0.3	0.5	-0.1	-0.7	-0.5	-0.6
Time in novel zone, hab. session 1	0.7	0.8	0.8	-0.9	0.9	0.9	0.8
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.6	-0.3	-0.0	-0.3
Total locomotion distance, hab. session 1	0.5	0.7	1.4	0.1	-1.2	-1.0	-0.4
Locomotion velocity, hab. session 1	0.4	0.5	0.9	0.3	-0.9	-0.9	-0.6
Time in familiar zone, hab. session 2	0.8	0.9	1.9	-0.7	1.1	1.4	0.2
Time in novel zone, hab. session 2	1.0	1.1	1.8	0.8	-1.3	-1.3	-0.7
Total zone transitions, hab. session 2	1.7	2.1	3.4	1.4	-1.4	-1.1	-1.8
Total locomotion distance, hab. session 2	1.0	1.3	2.0	0.5	-1.4	-1.1	-1.3
Locomotion velocity, hab. session 2	1.0	1.3	2.2	0.4	-1.5	-1.3	-1.1
Novel to familiar place preference ratio	1.3	1.7	2.8	1.7	-1.3	-1.1	-1.0
Novelty place preference	0.9	1.1	1.7	1.3	-1.2	-1.0	-0.7
Time in novel zone, NPP test	1.0	1.2	1.6	1.3	-1.2	-1.0	-0.8
Total zone transitions, NPP test	0.8	1.2	2.6	1.6	-0.9	-0.4	-1.2
Total locomotion distance, NPP test	0.3	0.4	0.6	0.3	-0.7	-0.5	-0.7
Locomotion velocity, NPP test	0.1	0.1	0.2	0.1	-0.4	-0.2	-0.4
Intraocular pressure	0.8	1.3	2.9	-1.1	0.8	0.8	1.7
Delta distance traveled before/after self-admin	1.7	1.9	2.8	-1.4	1.7	1.5	0.9
Delta ambulatory time before/after self-admin	1.1	1.9	2.8	-1.2	1.7	1.5	0.9
Parametrial fat weight	0.6	1.5	2.7	-0.9	-1.6	-1.5	0.6
Pavlov. Cond. lever latency	1.1	1.4	1.8	-1.1	1.0	1.2	1.4
Pavlov. Cond. magazine entry latency	1.8	2.4	2.9	1.5	-1.5	-1.7	-1.4
Pavlov. Cond. change in total contacts	0.9	1.0	1.5	1.0	-1.2	-1.2	-0.5
Pavlov. Cond. index score	0.6	0.7	0.9	0.9	-0.7	-0.9	-0.8
Pavlov. Cond. latency score	0.6	0.8	1.0	0.9	-0.7	-1.0	-1.0
Pavlov. Cond. lever contacts	0.9	1.1	1.5	0.9	-0.9	-1.2	-1.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.8	0.4	0.6	0.4
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.1	-0.9	0.7	0.4	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.4	1.2	-0.9	-1.0	-0.9
Pavlov. Cond. response bias	0.6	0.8	0.9	0.9	-0.8	-1.0	-0.8
Pavlov. Cond. lever latency	1.0	1.5	2.0	-1.4	1.4	1.0	0.9
Pavlov. Cond. magazine entry latency	2.3	3.3	6.2	2.5	-1.4	-1.1	-2.0
Pavlov. Cond. change in total contacts	1.1	2.6	4.1	2.0	-1.8	-1.3	-1.1
Pavlov. Cond. index score	2.2	3.5	5.8	2.4	-1.8	-1.5	-1.6
Pavlov. Cond. latency score	2.2	3.6	5.6	2.4	-1.9	-1.6	-1.6
Pavlov. Cond. lever contacts	0.7	1.1	1.7	1.3	-1.2	-0.7	-0.7
Pavlov. Cond. magazine entry number	3.9	5.1	9.8	-3.1	1.7	1.4	2.3
Pavlov. Cond. intertrial magazine entries	0.6	1.4	2.4	-1.2	0.9	0.9	1.6
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.7	6.4	2.5	-1.8	-1.4	-1.7
Pavlov. Cond. response bias	2.0	2.7	4.4	2.1	-1.6	-1.1	-1.6
Time in closed arm before self-admin	0.2	0.3	0.5	0.3	-0.6	-0.7	0.2
Time in closed arm after self-admin	0.2	0.2	0.6	-0.8	0.2	0.1	0.4
Time in open arm before self-admin	1.3	1.5	2.3	-1.5	1.4	1.3	0.2
Time in open arm after self-admin	0.1	0.1	0.2	0.1	0.4	0.4	-0.4
Bone: periosteal estimation	1.8	4.3	6.9	1.6	-2.4	-2.6	-1.4
Bone: periosteal perimeter	1.2	2.3	3.2	1.4	-1.8	-1.8	-1.0
Bone: post-yield work	4.9	8.4	13.4	2.5	-3.7	-3.3	-1.7
Progressive ratio test 1 active lever presses	0.1	0.2	0.4	0.0	-0.6	-0.5	0.2
Progressive ratio test 1 breakpoint	0.1	0.2	0.4	0.1	-0.6	-0.5	0.3
Progressive ratio test 1 inactive lever presses	0.3	0.7	1.0	0.5	-1.0	-1.0	-0.7
Progressive ratio test 2 active lever presses	0.6	0.9	1.7	-0.3	-1.3	-1.2	0.7
Progressive ratio test 2 breakpoint	0.7	0.9	1.8	-0.3	-1.4	-1.2	0.6
Progressive ratio test 2 inactive lever presses	0.5	1.4	1.7	-1.3	-1.3	-1.2	0.9
Incentive Sensitization - Responses	0.8	2.2	3.9	1.1	-2.0	-1.7	-0.9
Incentive Sensitization - Breakpoint	0.9	2.0	3.8	0.9	-2.0	-1.7	-0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.8	0.3	0.2	0.6
Progressive ratio	0.7	2.2	3.5	1.9	-1.4	-1.5	-1.1
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.0	-0.0	0.2	-0.2
Seeking ratio, punishment vs. effort	0.7	1.5	3.6	-1.9	1.0	1.1	0.5
Retroperitoneal fat weight	1.3	5.9	18.1	-4.3	-0.3	-0.4	2.3
Reaction time number correct	0.0	0.1	0.2	0.2	0.5	0.3	-0.4
Reaction time mean minus median	0.2	1.1	4.1	2.0	-0.4	-0.1	-0.2
Reaction time mean minus median AUC	0.1	0.5	1.3	1.1	0.3	0.8	0.2
Reaction time num false alarms	1.1	1.8	2.5	-1.6	1.6	1.5	0.5
Reaction time num false alarms AUC	0.6	1.3	2.2	-1.0	1.4	1.5	0.2
Reaction time trials correct on left	0.0	0.1	0.2	0.2	0.5	0.3	-0.4
Reaction time trials on left	0.0	0.2	0.3	0.3	0.5	0.4	-0.4
Reaction time mean	0.1	0.1	0.3	0.4	-0.0	0.2	0.6
Reaction time mean AUC	0.1	0.1	0.3	0.4	-0.1	0.2	0.6
Median of all reaction times	0.0	0.1	0.1	0.0	-0.2	-0.1	0.4
Reaction time omissions	0.2	0.3	0.6	0.8	0.4	0.7	0.0
Reaction time false alarm rate	0.6	0.8	1.2	-1.1	0.9	1.0	0.4
Reaction time premature initiation rate	1.8	2.8	7.4	1.4	-0.7	-1.1	-2.7
Reaction time premature initiations	0.8	2.3	6.6	1.5	-0.1	-0.5	-2.6
Std. dev. reaction times	0.2	0.5	0.7	0.6	0.5	0.9	0.9
Reaction time trials completed	0.0	0.2	0.3	0.3	0.5	0.4	-0.4
Reaction time trials AUC	0.0	0.1	0.2	0.2	0.5	0.3	-0.5
Run reversals in cocaine runway, females	1.6	1.8	3.2	0.8	-1.3	-1.2	-1.8
Run reversals in cocaine runway, males	0.4	0.5	0.6	-0.6	0.8	0.8	0.7
Latency to leave start box in cocaine runway	0.3	0.4	0.9	0.1	-0.9	-1.0	-0.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.1	-0.6	-0.6	-0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.1	-0.2	-0.4	0.4
Std. dev. time between licks in bursts	0.3	0.5	0.8	-0.8	0.7	0.9	-0.2
Total sessions with >9 infusions	0.1	0.1	0.2	0.2	-0.4	-0.4	0.1
Short access day 1 total inactive lever presses	0.3	0.5	1.1	-1.0	-0.6	-0.8	0.0
Short access day 10 total inactive lever presses	0.1	1.0	1.4	-1.2	0.9	0.8	1.0
Short access day 1 total infusions	0.2	0.3	0.7	-0.8	-0.4	-0.5	0.4
Short access day 10 total infusions	1.0	1.7	3.1	0.6	-1.8	-1.7	-0.7
Short access total infusions	0.5	0.7	1.4	0.1	-1.2	-1.1	-0.4
Short access day 1 locomotion	0.3	0.5	1.0	-0.3	-0.8	-1.0	0.1
Short access day 10 total locomotion	0.5	1.8	3.4	0.4	-1.8	-1.8	-0.7
Short access total locomotion	0.9	1.4	2.8	0.1	-1.7	-1.6	-0.4
One hour access (0.3 mA shock)	1.1	1.3	2.1	-1.0	-1.5	-1.3	0.6
Compulsive drug intake	0.5	0.7	1.3	0.0	1.0	1.1	-0.5
One hour access (shock baseline)	0.6	1.5	1.9	-1.1	-1.2	-1.2	1.4
Social response proportion	0.1	0.1	0.4	0.7	-0.1	0.0	-0.3
Social responses	0.3	0.4	0.9	0.1	0.9	0.9	0.0
Social time	0.4	0.6	1.4	0.0	0.9	1.2	0.2
Soleus weight	1.6	4.8	10.8	-3.3	1.3	1.0	2.4
Bone: stiffness	1.8	3.2	6.1	2.5	-1.6	-1.6	-1.4
Tibialis anterior weight	4.1	14.0	30.1	5.5	-1.9	-1.9	-4.3
Time to tail flick, vehicle, before self-admin	1.4	1.7	2.2	1.3	-1.5	-1.4	-1.0
Time to tail flick, vehicle, after self-admin	1.0	2.1	2.8	1.7	-1.2	-1.2	-1.6
Time to tail flick, test, before self-admin	1.8	2.0	3.2	0.0	-1.7	-1.8	-1.4
Time to tail flick, test, after self-admin	0.1	0.1	0.4	0.6	-0.1	-0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.6	-0.1	-0.1	-0.7
Delta time to tail flick, test, before/after SA	1.3	1.6	2.4	0.2	1.5	1.5	1.3
Tibia length	1.1	3.1	5.4	2.3	-1.7	-1.7	-1.1
Ambulatory time before self-admin	0.7	2.0	2.7	1.6	-1.4	-1.5	-1.1
Ambulatory time after self-admin	0.1	0.1	0.2	0.0	-0.3	-0.5	-0.0
Bone: tissue strength	0.1	0.1	0.2	-0.3	0.3	0.4	0.4
Total heroin consumption	1.3	1.5	4.0	2.0	0.1	-0.2	-1.4
Bone: trabecular number	2.1	3.9	4.5	2.1	-2.1	-2.0	-1.6
Bone: trabecular spacing	1.8	2.6	3.3	-1.7	1.8	1.8	1.1
Bone: trabecular thickness	0.1	0.1	0.4	-0.1	-0.4	-0.6	0.1
Bone: trabecular tissue density	4.4	7.7	10.9	-2.9	2.3	2.4	3.3
Water consumed over 24 hours	0.1	0.3	0.4	0.5	0.7	0.4	-0.4
Number of responses in last shaping day	0.1	0.1	0.1	-0.3	0.3	0.1	-0.4