Spdef

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Spdef	0.11	0.06	2.7e-03	0.04	0.03	0.04	0.04	1.6e-05	1.2e-04	2.4e-05	1.9e-05
2	Eye	gene expression	Spdef	0.42	0.17	3.2e-03	-0.01	0.02	-0.01	0.07	5.0e-01	1.5e-01	4.2e-01	2.8e-02
3	NAcc	gene expression	Spdef	0.16	0.06	4.7e-10	0.04	0.08	0.09	0.09	2.2e-05	1.9e-09	4.0e-10	1.9e-10
4	Brain	gene expression	Spdef	0.33	0.1	0.0e+00	0.14	0.18	0.19	0.19	2.3e-13	1.3e-16	2.8e-17	1.3e-17
5	PL	gene expression	Spdef	0.25	0.08	0.0e+00	0.22	0.2	0.23	0.23	2.1e-23	1.0e-21	8.6e-25	1.7e-24
6	BLA	gene expression	Spdef	0.17	0.08	1.2e-06	0.11	0.07	0.09	0.09	2.6e-06	1.3e-04	1.5e-05	1.5e-05
7	pVTA	gene expression	Spdef	0.2	0.09	1.5e-06	0.1	0.11	0.1	0.09	4.1e-05	1.8e-05	5.5e-05	7.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.2	0.3	0.6	-0.5	-0.3	0.5	0.6	-0.5	-0.8	0.5
Area under the delay curve	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.2	0.2	-0.2	-0.3
BMI with tail	1.0	3.3	7.0	-2.1	-2.6	-0.5	-1.1	1.5	2.5	-1.4
BMI without tail	0.2	0.3	1.5	-0.4	-0.1	-0.2	-0.3	0.7	1.2	-0.3
Body weight	2.9	12.3	17.3	2.1	-0.5	-3.9	-4.2	4.0	3.9	-4.1
Weight adjusted by age	2.2	2.5	3.5	1.7	0.6	-1.8	-1.9	1.5	1.6	-1.8
Bone surface	0.2	0.4	1.3	1.2	1.0	-0.5	-0.2	0.2	-0.3	-0.2
Bone volume	0.0	0.1	0.2	0.4	0.2	-0.2	-0.0	0.1	-0.4	0.1
Breakpoint value in progressive ratio session	0.5	0.5	1.2	0.3	-0.4	-1.1	-0.8	1.1	-0.2	-0.6
Number of licking bursts	0.3	0.4	1.6	0.8	1.3	0.2	0.4	-0.4	-0.4	0.3
Context. condit. distance diff. score	1.2	1.5	5.3	1.8	2.3	-0.1	0.2	-0.6	-1.2	0.1
Locomotion velocity, session 1	1.2	1.3	2.8	0.5	1.7	0.8	1.1	-1.3	-1.3	0.9
Locomotion distance, session 1	3.2	4.2	6.5	-1.3	0.6	2.4	2.6	-2.5	-1.9	2.2
Locomotion velocity, session 2	0.5	0.6	1.5	1.1	1.2	-0.0	0.2	-0.5	-0.7	0.5
Locomotion distance, session 2	0.6	0.9	1.6	-0.2	0.3	1.0	1.1	-1.3	-1.0	1.0
Locomotion velocity, session 3	1.1	1.3	1.9	-0.7	0.4	1.4	1.4	-1.3	-1.1	1.4
Locomotion distance, session 3	3.0	3.3	5.0	-1.2	0.5	2.2	2.2	-2.2	-1.8	1.8
Stereotopy head waving bouts, day 3	1.8	2.2	4.5	2.1	1.5	-1.6	-1.4	1.2	0.9	-1.3
Stereotopy head waving duration, day 3	0.7	0.8	2.2	1.5	1.2	-0.9	-0.7	0.5	0.2	-0.5
Locomotion velocity, session 7	0.9	1.0	1.6	-0.6	0.4	1.2	1.1	-1.3	-1.2	0.7
Locomotion distance, session 7	1.8	2.3	4.3	-0.4	0.5	1.6	1.7	-1.9	-2.1	1.5
Stereotopy head waving bouts, day 7	0.4	0.4	0.8	-0.5	0.2	0.8	0.7	-0.7	-0.6	0.9
Stereotopy head waving duration, day 7	0.0	0.0	0.2	-0.4	0.1	0.2	0.1	0.0	0.1	0.1
Locomotion velocity, session 8	2.4	2.9	8.8	3.0	2.9	-1.2	-0.7	0.3	-0.8	-0.6
Locomotion distance, session 8	1.2	1.8	3.7	1.3	1.9	0.7	1.0	-1.4	-1.7	0.9
Degree of sensitization distance	1.9	1.9	3.3	1.8	0.4	-1.8	-1.6	1.4	0.7	-1.3
Degree of sensitization stereotypy	1.5	1.6	2.3	-1.3	-0.1	1.5	1.5	-1.3	-1.1	1.5
Conditioned locomotion	3.3	3.9	6.4	1.7	-0.5	-2.5	-2.5	2.3	1.7	-1.9
Cocaine response after cond. corrected	0.4	0.4	1.2	-0.2	-0.7	-0.5	-0.5	0.6	1.1	-0.6
Cocaine response after cond. not corrected	0.4	0.5	1.0	0.7	0.4	-0.7	-0.6	0.6	1.0	-0.7
Cocaine response before conditioning	0.8	0.9	3.4	1.6	1.9	-0.5	-0.4	0.1	-0.1	-0.3
Saline control response	1.8	2.3	6.9	-1.5	-2.6	-0.6	-1.0	1.3	1.9	-0.6
Bone: connectivity density	0.0	0.0	0.1	0.1	0.3	-0.1	-0.0	0.0	-0.3	-0.1
Bone: cortical apparent density	0.6	0.8	2.8	-1.4	-1.7	0.3	0.1	0.2	0.8	0.0
Bone: cortical area	0.1	0.1	0.2	-0.4	0.1	0.4	0.3	-0.3	0.0	0.2
Bone: cortical porosity	1.2	1.3	3.1	-0.3	0.2	1.1	1.0	-1.3	-1.8	1.5
Bone: cortical porosity	0.5	0.6	1.6	0.5	0.9	0.5	0.4	-0.7	-1.3	0.7
Bone: cortical thickness	2.8	4.6	11.3	-3.4	-1.9	2.5	2.1	-1.7	-0.6	1.8
Bone: cortical thickness	1.6	1.8	5.5	-2.4	-2.3	0.9	0.6	-0.2	0.7	0.7
Bone: cortical tissue density	0.5	0.6	2.2	-1.1	-1.5	0.1	-0.1	0.3	0.8	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.1	0.1	0.3	0.2	-0.4	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.9	-0.3	-0.9	-0.4	-0.5	0.6	0.8	-0.4
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.0	-0.0	0.3	-0.1
Condit. Reinf. inactive responses	0.3	0.3	0.9	-0.9	-0.8	0.6	0.5	-0.4	0.1	0.3
Incentive salience index mean	0.2	0.3	0.9	0.8	0.9	0.1	0.1	-0.4	-0.5	0.0
Condit. Reinf. lever presses	0.4	0.5	1.9	1.1	1.4	-0.0	0.1	-0.3	-0.6	-0.1
Condit. Reinf. active minus inactive responses	0.3	0.3	0.9	1.0	0.8	-0.0	0.1	-0.4	-0.6	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.0	1.0	0.8	-0.2	-0.2	-0.1	-0.1	-0.2
Condit. Reinf. active responses	0.2	0.3	0.8	0.8	0.5	0.1	0.2	-0.5	-0.9	0.6
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.1	-0.5	-0.1	-0.0	-0.0	-0.3	0.4
Condit. Reinf. lever presses	0.8	1.0	1.9	-0.2	0.3	1.1	1.0	-1.3	-1.2	1.4
Condit. Reinf. lever reinforcers received	0.5	0.6	1.3	0.6	0.6	0.5	0.6	-0.9	-1.1	0.9
Conditioned reinforcement - actives	0.0	0.0	0.2	-0.0	0.1	0.0	-0.3	-0.0	0.1	-0.4
Conditioned reinforcement - inactives	0.2	0.3	0.5	-0.7	-0.2	0.7	0.4	-0.6	-0.1	0.5
Conditioned locomotion	0.3	0.4	0.9	0.5	0.2	-0.5	-0.9	0.5	0.4	-1.0
Patch foraging indifference point 0 sec	0.9	1.4	4.7	-1.6	-2.2	0.1	-0.2	0.6	1.4	-0.2
Patch foraging indifference point AUC	0.8	0.9	3.8	1.6	1.9	-0.1	0.1	-0.4	0.0	0.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.3	0.3	-0.0	-0.1	0.1	0.2	-0.4
Delay disc. indifference point, 16s delay	0.7	0.8	1.9	-1.4	-0.7	1.0	0.7	-0.7	-0.7	0.6
Delay disc. indifference point, 2s delay	0.4	0.4	1.0	1.0	0.9	-0.5	-0.6	0.3	-0.1	-0.7
Delay disc. indifference point, 24s delay	0.4	0.4	1.3	-1.1	-1.0	0.4	-0.2	0.1	-0.2	-0.2
Delay disc. indifference point, 4s delay	0.7	0.7	1.2	0.7	0.2	-0.9	-0.9	1.0	0.7	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.0	-0.2	-0.3	-0.5	0.5	-0.0	-0.5
Indifference point function ln k	0.4	0.5	2.0	-0.1	0.4	0.5	0.7	-0.6	-1.4	0.7
Indifference point function log k	0.4	0.5	2.0	-0.1	0.4	0.5	0.7	-0.6	-1.4	0.7
Patch foraging total patch changes 0 sec	1.0	1.5	5.1	-1.9	-2.3	0.4	0.0	0.3	1.3	0.0
Patch foraging total patch changes 12 sec	0.4	0.5	1.3	-1.2	-0.8	0.8	0.7	-0.5	0.2	0.6
Patch foraging total patch changes 18 sec	1.3	1.6	4.9	-1.9	-2.2	0.3	0.0	0.3	1.7	0.1
Patch foraging total patch changes 24 sec	1.8	2.1	5.3	-2.3	-2.1	1.4	1.1	-0.8	0.6	1.1
Patch foraging total patch changes 6 sec	1.3	1.9	5.2	-2.3	-2.2	1.1	0.7	-0.5	1.0	0.6
Patch foraging time to switch 0 sec	1.5	2.3	8.2	-1.6	-2.9	-0.7	-1.0	1.3	1.2	-0.8
Patch foraging water rate 0 sec	0.1	0.2	0.4	0.0	0.6	0.5	0.4	-0.5	0.3	-0.1
Patch foraging water rate 12 sec	1.3	2.0	3.2	-1.4	-0.4	1.8	1.7	-1.7	-0.8	1.6
Patch foraging water rate 18 sec	0.1	0.2	0.6	-0.4	-0.2	-0.0	-0.2	0.3	0.8	-0.5
Patch foraging water rate 24 sec	0.6	0.8	1.4	-0.8	0.2	1.2	1.2	-1.0	-0.8	0.8
Patch foraging water rate 6 sec	0.5	0.8	1.4	-0.5	0.3	1.1	1.2	-1.1	-0.5	1.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	0.3	0.3	-0.3	-0.0	0.3	-0.3	0.3
Distance traveled before self-admin	0.9	0.9	2.1	1.4	0.8	-1.3	-0.8	1.0	0.1	-0.8
Distance traveled after self-admin	1.1	1.2	2.4	1.4	0.4	-1.5	-1.1	1.3	0.4	-0.9
Extensor digitorum longus weight	0.5	1.8	6.0	2.5	2.1	-1.1	-0.7	0.3	-0.0	-0.7
Bone: elastic displacement	1.3	1.5	2.2	-1.3	-0.3	1.5	1.3	-1.4	-1.1	1.3
Bone: elastic work	0.3	0.4	1.0	-1.0	-0.7	0.7	0.5	-0.4	-0.2	0.4
Bone: endosteal estimation	5.9	12.9	18.4	4.1	1.7	-4.3	-4.0	3.7	2.8	-3.8
Bone: endosteal perimeter	3.2	6.6	10.8	3.3	1.7	-3.1	-2.7	2.5	1.7	-2.5
Epididymis fat weight	4.4	10.4	35.1	-5.9	-5.3	2.3	1.3	-0.6	1.0	1.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	-0.2	-0.7	-0.4	-0.5	0.6	0.0	-0.4
Delta time in open arm before/after self-admin	0.0	0.0	0.2	0.0	0.1	-0.0	0.0	0.0	0.4	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.5	-0.4	0.3	0.3	-0.2	-0.6	0.2
Delay discount exponential model param	0.0	0.0	0.2	0.2	0.0	-0.2	0.1	-0.0	0.4	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.2	-0.0	0.3	0.3	-0.3	-0.5	0.3
Active lever presses in extinction session 6	1.0	0.9	2.4	-0.9	-1.6	-0.4	-0.8	0.8	1.0	-0.8
Bone: final force	2.2	3.5	6.1	-0.8	-2.5	-1.4	-1.6	2.1	2.4	-1.7
Bone: final moment	1.7	2.7	4.5	-0.7	-2.1	-1.2	-1.5	1.9	2.1	-1.6
Food consumed during 24 hour testing period	3.1	3.7	5.7	1.1	-0.5	-2.4	-2.4	2.3	2.1	-1.9
Glucose	2.2	3.3	12.2	2.9	3.5	-0.7	-0.4	-0.2	-0.9	-1.0
Heart weight	1.5	2.2	3.6	-0.3	1.4	1.7	1.6	-1.9	-1.5	1.3
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.1	-0.2	-0.0	0.2	-0.1	0.4	0.3
Intermittent access intake day 1-15 change	0.1	0.1	0.3	0.2	-0.1	-0.3	-0.1	0.5	-0.1	0.0
Intermittent access intake escalation	0.6	0.6	1.1	1.0	0.4	-1.0	-0.7	1.0	0.2	-0.7
Intermittent access intake escalation 2	2.2	2.2	6.9	2.6	2.2	-1.3	-0.7	0.7	-0.6	-0.8
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.2	0.0	0.6	0.7	1.1	-0.8	-0.9	0.8
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.5	0.7	-0.1	-0.7	-0.5	0.7	0.6	-0.3
Intermitt. access escalation Index	0.5	0.5	0.9	-0.3	0.3	0.7	0.9	-0.7	-1.0	0.6
Intermittent access day 1 total infusions	0.2	0.2	0.4	-0.5	-0.1	0.6	0.3	-0.7	-0.5	0.2
Intermittent access day 15 total infusions	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.0	0.0	-0.0	-0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.0	-0.0	0.1	0.1	-0.2	0.0	-0.0	-0.2
Intermittent access total infusions	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.2	-0.1	0.2	-0.2
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.3	0.2	-0.2	-0.3	0.1	0.4	-0.3
Intermittent access day 15 total locomotion	2.4	2.6	3.7	1.3	-0.1	-1.9	-1.9	1.8	1.5	-1.8
Intermittent access total locomotion	2.1	2.4	3.4	1.3	0.2	-1.7	-1.8	1.6	1.8	-1.8
Intermittent access standard deviation	0.9	0.9	1.6	-0.2	-1.2	-0.8	-0.9	1.2	1.3	-0.6
Left kidney weight	0.9	2.7	4.3	1.3	-0.3	-2.0	-2.1	1.8	1.4	-1.8
Right kidney weight	1.7	4.7	7.3	2.4	0.7	-2.7	-2.5	2.3	1.6	-2.2
Cocaine induced anxiety	0.4	0.4	1.5	1.2	1.1	-0.5	0.1	0.1	0.1	-0.1
Post-drug Anxiety	0.4	0.4	1.0	1.0	0.9	-0.4	-0.1	0.3	0.8	-0.4
Baseline Anxiety	0.6	0.6	2.4	-1.5	-1.2	0.7	0.1	-0.1	0.4	0.2
Tail length	3.0	9.1	25.9	5.1	4.3	-2.8	-2.2	1.7	0.5	-1.8
Length with tail	2.8	10.1	22.2	4.7	2.7	-3.7	-3.3	2.6	1.4	-2.9
Length without tail	2.4	5.2	7.9	2.3	0.0	-2.7	-2.8	2.4	1.7	-2.7
Times rat made contact with spout	1.4	1.6	2.8	-1.7	-1.0	1.3	1.2	-1.1	-0.6	1.5
Lifetime Intake	0.1	0.1	0.1	-0.3	-0.3	0.1	-0.3	0.0	0.2	-0.3
Liver weight, left	4.7	7.5	11.5	3.3	1.3	-3.4	-3.0	2.8	2.3	-2.5
Liver weight, right	5.4	9.0	29.4	5.4	3.7	-3.1	-2.3	1.7	0.2	-1.7
Locomotor activity	0.1	0.1	0.7	0.4	0.8	-0.2	0.2	0.2	-0.1	0.0
Locomotor testing distance	0.2	0.3	0.8	-0.9	-0.3	0.5	0.7	-0.2	-0.2	0.5
Locomotor testing rearing	0.6	0.9	1.7	0.4	-0.2	-1.2	-1.0	1.3	0.9	-1.0
Locomotion in novel chamber	0.1	0.1	0.5	-0.2	0.1	0.4	0.3	-0.3	-0.7	0.1
Locomotion in novel chamber post-restriction	0.6	0.7	1.4	-0.5	-1.2	-0.6	-0.9	1.0	0.8	-0.9
Fecal boli incidents, locomotor time 1	0.3	0.3	0.7	0.1	-0.4	-0.5	-0.8	0.6	0.4	-0.8
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.5	-0.1	0.0	0.0	-0.1	0.0
Time >=10cm from walls, locomotor time 1	4.9	5.0	7.4	1.4	-0.5	-2.7	-2.4	2.7	2.5	-2.4
Bouts of movement, locomotor time 1	0.3	0.3	1.1	1.0	1.0	-0.2	0.1	-0.1	-0.3	0.1
Total resting periods, locomotor time 1	0.5	0.6	2.0	1.4	1.2	-0.6	-0.3	0.2	-0.1	-0.2
Rest time, locomotor task time 1	0.4	0.4	1.7	0.9	1.3	0.1	0.1	-0.4	-0.6	0.1
Distance moved, locomotor task time 1	0.7	0.8	1.5	-0.4	-1.2	-0.5	-0.7	1.0	1.2	-0.7
Vertical activity count, locomotor time 1	3.8	3.9	6.2	-0.0	-1.8	-2.1	-2.1	2.5	2.5	-1.8
Time >=10cm from walls, locomotor time 2	4.7	5.0	7.1	0.3	-1.5	-2.3	-2.5	2.7	2.7	-2.6
Bouts of movement, locomotor time 2	1.7	1.8	5.7	2.4	1.6	-1.5	-0.9	0.8	0.4	-0.6
Total resting periods, locomotor time 2	1.8	1.9	6.7	2.6	2.2	-1.2	-0.5	0.4	-0.2	-0.2
Rest time, locomotor task time 2	1.1	1.2	4.0	2.0	1.9	-0.7	-0.3	0.3	-0.1	-0.6
Distance moved, locomotor task time 2	1.8	2.1	4.7	-1.2	-2.2	-0.7	-1.3	1.3	1.9	-1.1
Vertical activity count, locomotor time 2	2.2	2.5	4.3	-0.5	-1.7	-1.3	-1.7	1.7	2.1	-1.5
Light reinforcement 1	0.9	1.6	2.6	-0.3	-1.5	-1.3	-1.2	1.6	1.4	-1.0
Light reinforcement 2	2.3	3.1	5.2	1.2	-0.7	-2.3	-2.2	2.2	1.4	-1.7
Bone: marrow area	6.1	13.1	18.7	4.1	1.7	-4.3	-4.0	3.8	3.0	-3.8
Bone: maximum diameter	1.3	2.4	7.0	2.6	2.4	-1.3	-1.0	0.7	0.1	-1.0
Bone: maximum force	0.6	1.0	2.0	-0.3	-1.1	-0.8	-0.9	1.1	1.4	-1.1
Bone: maximum moment	0.4	0.7	1.4	-0.1	-0.7	-0.7	-0.8	0.9	1.2	-1.1
Mean time between licks in bursts	2.3	3.2	10.7	3.3	2.9	-0.7	-0.1	-0.5	-1.5	0.4
Mean num. licks in bursts	0.8	0.9	2.7	-1.6	-1.5	0.8	0.5	-0.4	-0.1	0.7
Cd content in liver	1.4	1.5	3.3	-1.5	-1.8	-0.1	-0.8	0.9	1.4	-1.2
Co content in liver	2.0	2.4	6.8	-1.9	-2.6	-0.3	-0.7	1.2	1.9	-0.9
Cu content in liver	3.7	4.5	7.4	-2.7	-1.3	2.6	2.3	-2.1	-1.5	1.9
Fe content in liver	0.3	0.4	0.7	0.2	-0.8	-0.7	-0.7	0.6	0.5	-0.6
K content in liver	1.3	1.3	2.7	1.3	1.6	0.3	0.7	-1.0	-1.5	0.8
Mg content in liver	3.0	3.1	8.3	2.2	2.9	0.5	1.0	-1.5	-2.0	1.0
Mn content in liver	3.4	3.8	13.4	3.7	3.1	-1.5	-0.8	0.4	-0.6	-0.7
Na content in liver	0.2	0.2	0.6	0.1	0.5	0.3	0.4	-0.5	-0.8	0.6
Rb content in liver	0.6	0.8	1.5	0.5	0.2	-0.8	-0.9	0.8	1.2	-1.2
Se content in liver	4.6	5.6	15.0	3.1	3.9	0.5	1.1	-1.8	-2.9	1.3
Sr content in liver	0.4	0.3	0.8	-0.3	-0.5	-0.4	-0.7	0.5	0.6	-0.9
Zn content in liver	0.3	0.3	1.0	1.0	0.5	-0.5	-0.5	0.1	-0.2	-0.6
Bone: minimum diameter	2.0	3.7	5.3	2.3	1.3	-2.2	-2.0	1.8	1.6	-1.9
Time in familiar zone, hab. session 1	1.2	1.1	1.5	-1.2	-0.9	1.2	1.0	-1.0	-1.0	1.1
Time in novel zone, hab. session 1	0.3	0.3	0.6	0.6	0.8	-0.5	-0.4	0.4	0.5	-0.7
Total zone transitions, hab. session 1	3.5	4.9	7.7	-1.7	0.5	2.7	2.8	-2.6	-2.1	2.3
Total locomotion distance, hab. session 1	3.0	4.2	6.5	-0.9	0.9	2.3	2.5	-2.5	-2.2	2.3
Locomotion velocity, hab. session 1	2.7	3.9	5.6	-0.7	0.9	2.1	2.3	-2.4	-2.2	2.3
Time in familiar zone, hab. session 2	0.2	0.2	0.6	0.1	-0.0	0.2	0.4	-0.3	-0.6	0.7
Time in novel zone, hab. session 2	0.7	0.7	1.4	-0.2	-0.2	-0.6	-0.9	0.8	1.2	-1.2
Total zone transitions, hab. session 2	1.1	1.4	2.6	-0.8	0.4	1.4	1.6	-1.4	-0.9	1.2
Total locomotion distance, hab. session 2	2.3	3.1	5.2	-0.9	0.6	2.0	2.3	-2.1	-1.7	2.0
Locomotion velocity, hab. session 2	3.0	4.0	6.4	-0.7	0.9	2.2	2.5	-2.4	-2.1	2.3
Novel to familiar place preference ratio	0.3	0.3	0.6	-0.8	-0.7	0.6	0.4	-0.4	-0.2	0.4
Novelty place preference	0.2	0.2	0.4	-0.6	-0.5	0.5	0.4	-0.4	-0.2	0.3
Time in novel zone, NPP test	0.1	0.1	0.2	-0.4	-0.3	0.3	0.2	-0.2	-0.1	0.2
Total zone transitions, NPP test	2.0	2.9	4.6	-0.6	1.0	1.9	2.1	-2.1	-1.8	1.8
Total locomotion distance, NPP test	1.1	1.4	2.4	-1.0	0.0	1.5	1.6	-1.5	-1.0	1.2
Locomotion velocity, NPP test	1.8	2.5	4.1	-1.3	-0.1	1.9	2.0	-1.9	-1.3	1.6
Intraocular pressure	0.2	0.3	0.6	0.4	-0.2	-0.8	-0.6	0.6	0.7	-0.6
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.1	-0.3	-0.4	-0.5	0.5	0.4	-0.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	0.4	0.0	-0.5	-0.5	0.5	0.5	-0.4
Parametrial fat weight	0.7	1.4	2.4	0.1	-0.8	-1.3	-1.3	1.5	1.4	-1.1
Pavlov. Cond. lever latency	2.7	3.4	6.5	-1.0	-2.4	-1.4	-1.6	2.0	2.5	-1.3
Pavlov. Cond. magazine entry latency	2.0	2.6	8.6	1.8	2.9	0.6	0.9	-1.3	-1.6	0.9
Pavlov. Cond. change in total contacts	0.5	0.5	1.9	0.7	1.4	0.4	0.4	-0.6	-0.8	0.3
Pavlov. Cond. index score	2.4	3.0	7.8	1.5	2.8	1.0	1.2	-1.7	-2.2	1.0
Pavlov. Cond. latency score	2.3	2.9	7.1	1.6	2.7	0.9	1.1	-1.6	-2.2	1.0
Pavlov. Cond. lever contacts	2.0	2.3	4.8	0.8	2.2	1.2	1.3	-1.7	-2.1	0.9
Pavlov. Cond. magazine entry number	1.8	2.3	5.8	-1.2	-2.4	-1.0	-1.3	1.5	1.6	-1.1
Pavlov. Cond. intertrial magazine entries	0.9	1.0	3.9	-1.7	-2.0	0.4	0.0	0.1	0.7	0.0
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	7.2	1.3	2.7	1.1	1.3	-1.8	-2.2	1.1
Pavlov. Cond. response bias	2.6	3.2	9.2	1.5	3.0	1.1	1.3	-1.8	-2.0	1.0
Pavlov. Cond. lever latency	0.9	1.2	2.1	0.2	-0.0	-1.1	-1.1	1.4	1.3	-1.5
Pavlov. Cond. magazine entry latency	1.0	1.2	1.8	1.3	0.4	-1.3	-1.3	1.0	0.8	-1.1
Pavlov. Cond. change in total contacts	0.3	0.4	1.0	-0.1	-0.3	0.5	0.5	-0.7	-0.8	1.0
Pavlov. Cond. index score	0.1	0.1	0.2	0.5	0.2	0.0	-0.0	-0.3	-0.3	0.3
Pavlov. Cond. latency score	0.1	0.1	0.3	0.6	0.2	-0.2	-0.2	-0.1	-0.2	0.2
Pavlov. Cond. lever contacts	0.9	1.2	2.0	-1.0	-0.7	1.2	1.1	-1.2	-0.9	1.4
Pavlov. Cond. magazine entry number	0.5	0.6	0.9	-0.5	0.3	0.9	0.9	-0.8	-0.9	0.7
Pavlov. Cond. intertrial magazine entries	0.9	1.2	3.7	1.9	1.9	-0.3	0.2	-0.3	-1.0	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.2	0.5	0.0	-0.1	-0.2	-0.1	-0.1	0.2
Pavlov. Cond. response bias	0.3	0.5	1.0	-0.1	-0.0	0.7	0.6	-0.9	-0.7	1.0
Time in closed arm before self-admin	0.0	0.0	0.1	-0.3	-0.2	0.2	-0.0	0.0	0.1	-0.3
Time in closed arm after self-admin	0.3	0.3	0.7	-0.9	-0.7	0.6	0.3	-0.3	-0.4	0.2
Time in open arm before self-admin	0.7	0.8	1.8	1.0	1.3	0.1	0.2	-0.5	-1.3	0.7
Time in open arm after self-admin	0.4	0.5	1.7	1.0	1.3	-0.0	0.1	-0.4	-0.6	0.2
Bone: periosteal estimation	2.2	4.5	6.2	2.4	1.1	-2.5	-2.3	2.2	1.8	-2.2
Bone: periosteal perimeter	1.0	1.7	2.5	1.5	0.6	-1.6	-1.5	1.4	1.2	-1.3
Bone: post-yield work	1.2	1.6	2.4	1.5	0.9	-1.4	-1.3	1.2	0.9	-1.5
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.4	-0.2	0.4	-0.1	-0.2	0.1	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.6	-0.3	0.5	0.1	-0.3	0.1	0.1
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.9	-1.1	-1.4	0.1	-0.1	0.3	0.2	-0.1
Progressive ratio test 2 active lever presses	0.0	0.1	0.2	-0.4	-0.4	0.2	-0.0	0.0	-0.1	-0.0
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	-0.7	-0.4	0.5	0.4	-0.3	-0.3	0.3
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.9	0.9	0.8	-0.3	-0.3	-0.0	-0.2	-0.3
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.1	0.3	0.4	0.7	-0.4	-0.7	0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.0	0.3	0.3	0.6	-0.3	-0.6	0.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.0	0.2	0.4	0.2	-0.5	-0.4	0.3
Progressive ratio	1.9	2.2	4.1	0.0	-1.4	-1.6	-1.6	2.0	1.6	-1.3
Food seeking constrained by brief footshock	0.2	0.3	1.0	-0.8	-1.0	0.2	-0.2	0.2	0.2	-0.1
Seeking ratio, punishment vs. effort	1.6	1.9	3.4	-0.6	0.7	1.8	1.5	-1.8	-1.4	1.4
Retroperitoneal fat weight	0.2	0.5	1.1	-0.3	-1.0	-0.6	-0.8	0.8	0.7	-0.7
Reaction time number correct	0.7	0.9	3.3	-1.7	-1.8	0.4	0.2	0.3	0.5	0.0
Reaction time mean minus median	4.0	5.2	14.4	3.8	2.8	-2.4	-1.9	1.5	0.4	-1.5
Reaction time mean minus median AUC	3.6	4.7	11.9	3.5	2.3	-2.4	-2.1	1.5	0.4	-1.7
Reaction time num false alarms	0.3	0.5	1.9	1.4	1.0	-0.3	0.0	-0.1	-0.4	0.4
Reaction time num false alarms AUC	0.5	0.7	1.7	1.3	1.3	0.0	0.4	-0.5	-0.8	0.8
Reaction time trials correct on left	0.7	0.9	3.3	-1.7	-1.8	0.4	0.2	0.3	0.5	0.0
Reaction time trials on left	0.6	0.9	3.1	-1.6	-1.8	0.3	0.1	0.4	0.5	-0.0
Reaction time mean	3.3	4.7	8.5	2.9	1.8	-2.5	-2.2	1.9	1.2	-2.1
Reaction time mean AUC	3.7	5.0	8.2	2.9	1.6	-2.6	-2.4	2.1	1.3	-2.3
Median of all reaction times	2.2	3.0	4.4	2.0	1.0	-2.1	-1.9	1.7	1.2	-1.9
Reaction time omissions	1.4	2.0	4.3	2.1	1.7	-1.6	-1.1	1.1	0.6	-1.2
Reaction time false alarm rate	1.2	1.7	5.0	2.0	2.2	0.0	0.4	-0.8	-1.2	0.8
Reaction time premature initiation rate	0.0	0.0	0.1	-0.3	-0.2	-0.2	-0.2	0.3	-0.2	-0.2
Reaction time premature initiations	0.4	0.6	1.8	-1.1	-1.3	-0.3	-0.4	0.7	0.4	-0.4
Std. dev. reaction times	4.3	6.1	15.8	4.0	2.9	-2.7	-2.1	1.7	0.6	-1.8
Reaction time trials completed	0.6	0.9	3.1	-1.6	-1.8	0.3	0.1	0.4	0.5	-0.0
Reaction time trials AUC	0.6	0.9	3.3	-1.6	-1.8	0.2	0.1	0.4	0.6	-0.1
Run reversals in cocaine runway, females	0.6	0.5	1.7	-1.3	-1.3	0.6	0.1	-0.2	0.2	0.1
Run reversals in cocaine runway, males	1.4	1.3	5.1	1.9	2.3	-0.7	-0.5	0.0	-0.0	-0.4
Latency to leave start box in cocaine runway	0.3	0.3	0.5	-0.3	0.1	0.7	0.7	-0.7	-0.2	0.5
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.2	0.1	0.5	0.5	-0.5	-0.0	0.3
Latency to leave start box in cocaine runway, M	0.6	0.6	1.1	-0.6	-0.2	1.0	0.9	-0.8	-0.4	0.8
Std. dev. time between licks in bursts	2.3	2.8	8.2	2.7	2.9	-0.3	0.2	-0.7	-1.8	0.4
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	-0.0	-0.0	-0.3	-0.0	0.3	-0.3
Short access day 1 total inactive lever presses	0.6	0.6	1.7	1.2	1.3	-0.2	-0.2	-0.0	-0.9	-0.5
Short access day 10 total inactive lever presses	0.5	0.5	0.9	0.8	0.8	0.1	0.9	-0.3	-0.8	0.8
Short access day 1 total infusions	0.3	0.4	0.7	0.1	0.6	0.7	0.4	-0.8	-0.8	0.3
Short access day 10 total infusions	0.1	0.1	0.2	-0.1	-0.4	-0.1	-0.3	0.2	0.2	-0.2
Short access total infusions	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.1	-0.2	-0.1	-0.1
Short access day 1 locomotion	0.6	0.6	1.2	-0.1	0.3	0.8	0.9	-0.9	-1.1	0.9
Short access day 10 total locomotion	0.8	0.9	3.1	1.7	1.8	-0.2	0.2	-0.2	-0.2	-0.1
Short access total locomotion	0.2	0.2	0.6	0.8	0.4	-0.4	-0.3	0.2	0.3	-0.4
One hour access (0.3 mA shock)	0.5	0.6	1.1	0.2	0.9	0.6	0.8	-0.8	-1.0	0.5
Compulsive drug intake	0.6	0.6	2.3	0.1	0.6	0.4	0.7	-0.6	-1.5	0.5
One hour access (shock baseline)	0.5	0.6	0.9	1.0	0.8	-0.6	-0.8	0.4	0.9	-0.8
Social response proportion	0.3	0.3	0.7	0.8	0.4	-0.6	-0.6	0.3	0.5	-0.4
Social responses	0.1	0.1	0.6	0.8	0.4	-0.3	-0.1	0.2	-0.2	0.1
Social time	1.7	2.3	7.3	2.7	2.7	-1.1	-0.3	0.3	-0.6	-0.4
Soleus weight	3.2	9.3	27.9	5.3	4.6	-2.7	-2.0	1.2	0.1	-1.9
Bone: stiffness	0.5	0.8	1.5	-0.3	-1.2	-0.8	-0.7	1.1	1.2	-0.7
Tibialis anterior weight	0.2	0.6	1.1	-0.5	-0.2	0.8	1.0	-0.9	-0.6	1.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	0.6	0.3	-0.4	0.1	0.4	0.5	-0.2
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.9	0.9	0.4	-0.9	-0.6	0.7	0.7	-0.8
Time to tail flick, test, before self-admin	0.6	0.6	1.3	-0.6	-0.1	0.8	1.0	-0.8	-0.7	1.1
Time to tail flick, test, after self-admin	0.7	0.8	1.4	0.7	1.2	0.5	0.8	-0.8	-1.2	0.8
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	-0.7	-0.6	0.4	-0.1	-0.2	0.2	-0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.2	0.3	0.3	-0.3
Tibia length	2.6	7.4	10.6	3.1	1.6	-3.3	-2.9	2.9	1.9	-2.9
Ambulatory time before self-admin	0.3	0.3	0.6	0.8	0.4	-0.7	-0.4	0.5	-0.3	-0.3
Ambulatory time after self-admin	0.6	0.6	1.4	1.2	0.5	-1.1	-0.7	0.9	0.0	-0.6
Bone: tissue strength	0.5	0.5	0.9	-1.0	-0.9	0.1	-0.2	0.4	0.9	-0.9
Total heroin consumption	0.1	0.1	0.2	0.5	0.2	-0.4	-0.2	0.3	-0.2	-0.1
Bone: trabecular number	0.6	1.0	1.4	-0.9	-0.4	1.1	1.1	-1.0	-1.2	1.1
Bone: trabecular spacing	1.5	1.9	2.8	0.8	-0.2	-1.6	-1.7	1.6	1.6	-1.5
Bone: trabecular thickness	0.1	0.1	0.2	0.2	-0.2	-0.4	-0.3	0.3	0.1	-0.2
Bone: trabecular tissue density	0.3	0.4	1.1	1.0	1.1	-0.3	-0.2	-0.1	-0.5	0.1
Water consumed over 24 hours	0.1	0.1	0.6	-0.1	0.8	-0.0	0.0	0.1	0.3	-0.4
Number of responses in last shaping day	1.3	1.4	3.3	0.7	1.6	1.0	0.7	-1.3	-1.8	0.7