Hub : Genes

Spdef

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Spdef 0.12 0.07 1.5e-03 0.04 0.04 0.04 0.04 1.4e-05 4.8e-05 8.1e-06 1.0e-05
2 NAcc gene expression Spdef 0.15 0.06 3.7e-14 0.04 0.08 0.09 0.09 1.5e-06 5.0e-12 6.2e-14 3.5e-13
3 Eye gene expression Spdef 0.45 0.17 2.2e-03 0.05 0.01 0 0.11 5.8e-02 2.0e-01 2.9e-01 8.9e-03
4 Brain gene expression Spdef 0.32 0.1 0.0e+00 0.14 0.18 0.19 0.19 2.9e-13 3.3e-16 2.3e-17 2.6e-17
5 IC gene expression Spdef 0.34 0.13 2.7e-08 0.19 0.14 0.16 0.18 1.9e-08 2.5e-06 2.2e-07 3.9e-08
6 PL gene expression Spdef 0.25 0.08 0.0e+00 0.21 0.2 0.22 0.22 2.5e-22 6.0e-22 1.9e-23 1.6e-23
7 RMTg gene expression Spdef 0.25 0.12 5.9e-05 0.14 0.16 0.16 0.16 1.2e-04 6.5e-05 6.1e-05 4.1e-05
8 BLA gene expression Spdef 0.18 0.08 7.4e-07 0.12 0.09 0.1 0.1 5.5e-07 1.9e-05 1.0e-05 4.9e-06
9 pVTA gene expression Spdef 0.13 0.05 5.1e-09 0.09 0.1 0.11 0.1 9.9e-08 8.3e-09 6.6e-09 1.8e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.10.50.50.5-0.30.40.10.10.10.70.1
Area under the delay curve0.20.20.8-0.1-0.4-0.4-0.5-0.4-0.4-0.90.3-0.4
BMI with tail1.13.911.42.00.1-3.4-0.1-1.9-2.0-2.5-2.0-1.3
BMI without tail0.61.73.41.2-0.5-1.9-0.3-1.4-1.4-1.7-1.6-0.9
Body weight2.812.217.6-2.9-4.2-1.1-4.1-3.9-3.9-2.6-3.8-3.7
Weight adjusted by age1.52.34.0-1.8-1.90.2-2.0-1.2-1.2-1.0-1.6-1.8
Bone surface0.30.61.7-1.3-0.81.0-0.8-0.2-0.20.70.3-0.6
Bone volume0.10.10.3-0.5-0.40.2-0.5-0.3-0.30.10.3-0.4
Breakpoint value in progressive ratio session0.50.61.4-0.2-0.7-0.6-0.7-1.2-1.2-0.30.3-0.8
Number of licking bursts0.40.62.1-0.7-0.11.50.10.60.61.40.40.4
Context. condit. distance diff. score1.31.54.9-1.6-0.42.2-0.20.90.91.71.10.4
Locomotion velocity, session 11.21.33.2-0.40.51.80.51.31.31.31.50.8
Locomotion distance, session 13.03.85.21.32.30.82.22.32.31.72.11.9
Locomotion velocity, session 20.60.71.7-0.9-0.01.30.10.80.81.30.90.5
Locomotion distance, session 20.71.01.60.41.10.61.11.31.30.91.10.8
Locomotion velocity, session 31.31.52.30.91.20.61.41.41.41.11.21.5
Locomotion distance, session 32.93.14.71.51.90.72.22.12.11.41.81.8
Stereotopy head waving bouts, day 31.41.63.8-1.9-1.91.1-1.6-0.8-0.80.2-0.9-1.1
Stereotopy head waving duration, day 30.50.51.6-1.3-1.01.0-0.9-0.2-0.20.2-0.2-0.3
Locomotion velocity, session 70.80.92.20.61.10.41.01.11.10.31.50.8
Locomotion distance, session 71.82.34.40.71.60.61.51.81.80.82.11.9
Stereotopy head waving bouts, day 70.20.20.60.60.30.40.50.40.40.40.30.8
Stereotopy head waving duration, day 70.00.00.20.4-0.10.20.1-0.0-0.00.1-0.20.0
Locomotion velocity, session 82.02.57.4-2.7-1.52.7-1.30.20.21.61.0-0.2
Locomotion distance, session 81.62.34.3-0.90.62.00.71.71.72.11.81.0
Degree of sensitization distance1.51.53.7-1.9-1.60.1-1.8-1.2-1.2-0.6-0.7-0.9
Degree of sensitization stereotypy1.21.32.01.41.30.31.41.11.10.71.01.4
Conditioned locomotion2.83.25.0-1.8-2.1-0.7-2.2-2.0-2.1-0.9-1.8-1.7
Cocaine response after cond. corrected0.40.51.1-0.1-0.4-0.7-0.5-0.8-0.8-0.4-1.1-0.9
Cocaine response after cond. not corrected0.40.50.9-0.8-0.90.3-0.8-0.6-0.60.2-1.0-0.8
Cocaine response before conditioning0.80.93.3-1.4-1.11.8-0.60.40.41.10.1-0.1
Saline control response1.82.44.91.0-0.4-2.2-0.6-1.7-1.7-2.1-2.1-0.7
Bone: connectivity density0.10.10.4-0.3-0.10.2-0.3-0.2-0.20.10.2-0.6
Bone: cortical apparent density0.50.72.31.40.7-1.50.7-0.3-0.3-0.7-0.9-0.2
Bone: cortical area0.10.10.20.20.10.30.40.40.40.40.10.1
Bone: cortical porosity1.21.33.50.61.00.60.91.21.20.31.81.9
Bone: cortical porosity0.60.71.8-0.10.30.90.30.90.90.21.31.2
Bone: cortical thickness2.23.710.93.32.6-1.42.71.41.40.20.81.5
Bone: cortical thickness1.41.75.72.21.3-2.41.1-0.3-0.3-0.9-0.60.4
Bone: cortical tissue density0.40.61.81.10.5-1.40.5-0.4-0.4-0.6-0.9-0.3
Condit. Reinf. active minus inactive responses0.10.10.3-0.00.10.00.20.50.5-0.30.30.3
Condit. Reinf. active-inactive response ratio0.40.40.90.1-0.4-1.0-0.4-0.6-0.6-0.9-0.8-0.5
Condit. Reinf. active responses0.10.10.50.1-0.0-0.5-0.00.10.1-0.7-0.2-0.2
Condit. Reinf. inactive responses0.20.30.70.80.7-0.80.60.30.3-0.40.10.3
Incentive salience index mean0.20.30.6-0.7-0.20.80.00.70.70.30.50.0
Condit. Reinf. lever presses0.40.61.8-1.2-0.61.3-0.30.60.60.80.5-0.3
Condit. Reinf. active minus inactive responses0.20.30.6-0.7-0.10.8-0.00.60.60.40.60.6
Condit. Reinf. active-inactive response ratio0.20.20.7-0.9-0.50.8-0.30.40.30.20.20.0
Condit. Reinf. active responses0.20.30.7-0.50.20.60.10.70.60.60.80.7
Condit. Reinf. inactive responses0.00.00.10.10.3-0.30.0-0.1-0.10.10.20.4
Condit. Reinf. lever presses0.81.12.20.41.00.80.91.31.30.91.21.5
Condit. Reinf. lever reinforcers received0.50.71.2-0.30.50.80.51.11.00.91.01.0
Conditioned reinforcement - actives0.00.10.10.0-0.20.2-0.3-0.3-0.3-0.2-0.2-0.4
Conditioned reinforcement - inactives0.20.30.40.70.60.10.50.60.60.00.30.6
Conditioned locomotion0.70.91.6-0.8-1.0-0.2-1.3-0.8-0.8-1.2-0.6-1.2
Patch foraging indifference point 0 sec0.61.12.91.30.3-1.7-0.0-1.2-1.1-1.0-1.4-0.3
Patch foraging indifference point AUC0.71.13.0-1.2-0.51.70.11.11.01.60.20.5
Delay disc. indifference point, 0s delay0.10.10.2-0.4-0.50.0-0.4-0.1-0.1-0.4-0.1-0.4
Delay disc. indifference point, 16s delay0.50.61.81.30.9-0.50.70.40.4-0.30.80.8
Delay disc. indifference point, 2s delay0.30.41.1-1.0-0.60.5-0.8-0.2-0.2-0.50.2-0.7
Delay disc. indifference point, 24s delay0.40.51.81.00.2-1.1-0.0-0.2-0.2-1.30.40.0
Delay disc. indifference point, 4s delay0.70.71.5-0.9-1.2-0.2-1.0-0.8-0.8-0.7-0.5-1.0
Delay disc. indifference point, 8s delay0.30.31.1-0.2-0.5-0.5-0.7-0.6-0.6-1.10.1-0.3
Indifference point function ln k0.30.62.20.30.70.80.50.40.50.81.50.8
Indifference point function log k0.30.62.20.30.70.80.50.40.50.81.50.8
Patch foraging total patch changes 0 sec0.61.23.21.60.6-1.80.3-0.9-0.9-1.0-1.3-0.1
Patch foraging total patch changes 12 sec0.20.31.01.00.7-0.30.80.30.30.5-0.00.5
Patch foraging total patch changes 18 sec0.81.13.51.40.6-1.90.4-0.8-0.7-0.8-1.60.1
Patch foraging total patch changes 24 sec0.91.54.22.01.6-1.91.30.30.3-0.7-0.60.8
Patch foraging total patch changes 6 sec0.81.23.81.91.2-1.80.9-0.1-0.1-1.0-0.80.3
Patch foraging time to switch 0 sec1.42.98.31.0-0.1-2.9-0.6-2.0-2.0-2.3-1.3-1.3
Patch foraging water rate 0 sec0.10.20.90.00.10.90.20.50.50.6-0.50.1
Patch foraging water rate 12 sec0.91.83.31.61.7-0.01.81.41.40.90.71.5
Patch foraging water rate 18 sec0.20.30.90.2-0.5-0.3-0.3-0.5-0.5-0.6-1.0-0.5
Patch foraging water rate 24 sec0.60.81.51.01.10.31.20.90.90.90.80.8
Patch foraging water rate 6 sec0.50.71.20.81.10.31.00.90.90.90.51.0
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.3-0.30.1-0.1-0.3-0.30.60.20.1
Distance traveled before self-admin0.50.71.4-1.2-1.20.5-0.9-0.7-0.70.5-0.2-0.9
Distance traveled after self-admin1.31.63.3-1.7-1.80.6-1.5-1.3-1.30.3-0.8-1.1
Extensor digitorum longus weight0.41.65.4-2.3-1.22.1-1.10.20.21.30.3-0.5
Bone: elastic displacement1.01.22.01.41.4-0.01.21.01.0-0.01.31.2
Bone: elastic work0.20.30.80.90.6-0.50.50.20.2-0.60.50.1
Bone: endosteal estimation5.311.622.6-4.7-4.81.3-4.5-2.9-2.9-1.0-2.7-3.5
Bone: endosteal perimeter2.75.713.0-3.6-3.41.2-3.1-1.9-1.9-0.3-1.5-2.4
Epididymis fat weight4.615.952.17.23.9-6.83.3-1.0-1.0-3.6-1.90.3
Delta time in closed arm before/after self-admin0.60.62.00.80.2-1.4-0.2-0.7-0.7-1.20.1-0.4
Delta time in open arm before/after self-admin0.40.40.9-0.9-0.90.8-0.5-0.1-0.10.2-0.8-0.3
Diff in mean of infusions in LGA sessions0.10.20.50.70.5-0.50.4-0.0-0.00.10.5-0.1
Delay discount exponential model param0.20.20.70.10.30.40.40.30.30.8-0.40.3
Extinction: sum of active levers before priming0.20.20.40.40.50.20.60.40.40.60.50.0
Active lever presses in extinction session 60.60.61.80.90.2-1.3-0.1-0.5-0.5-1.4-0.3-0.2
Bone: final force1.93.05.60.3-0.9-2.4-1.0-2.0-2.0-2.1-2.1-1.7
Bone: final moment1.52.33.90.2-0.9-2.0-1.0-1.8-1.7-2.0-1.8-1.5
Food consumed during 24 hour testing period2.93.96.5-1.5-2.0-0.9-2.4-2.5-2.5-1.5-1.9-2.0
Glucose1.42.27.6-2.4-1.52.8-1.20.50.51.00.5-0.7
Heart weight0.50.81.80.50.91.10.81.31.40.50.50.6
Delay discount hyperbolic model param0.10.10.40.10.20.10.30.10.10.6-0.60.1
Intermittent access intake day 1-15 change0.20.40.9-0.3-0.7-0.7-0.6-0.9-1.0-0.5-0.3-0.5
Intermittent access intake escalation0.30.71.40.0-0.7-1.2-0.6-1.1-1.2-1.0-0.5-0.4
Intermittent access intake escalation 20.60.71.8-1.3-1.30.5-1.1-0.7-0.7-0.4-0.1-0.7
Intermitt. access day 1 inactive lever presses0.41.65.0-0.10.71.41.11.21.22.21.30.9
Intermitt. access day 15 inactive lever presses0.20.41.2-1.1-0.80.4-0.7-0.5-0.40.2-0.7-0.6
Intermitt. access escalation Index0.91.22.60.50.90.61.41.21.21.61.30.8
Intermittent access day 1 total infusions0.20.40.60.60.70.80.40.70.80.10.50.6
Intermittent access day 15 total infusions0.10.10.30.50.2-0.30.1-0.1-0.1-0.6-0.10.3
Intermittent access terminal intake (last 3 days)0.10.10.40.60.3-0.10.20.20.2-0.50.00.4
Intermittent access total infusions0.10.10.10.40.30.30.10.30.4-0.3-0.10.4
Intermittent access day 1 locomotion0.10.10.5-0.3-0.20.2-0.2-0.00.0-0.2-0.7-0.3
Intermittent access day 15 total locomotion1.73.03.9-1.3-1.9-0.9-2.0-1.9-1.8-1.9-1.7-1.9
Intermittent access total locomotion1.11.32.3-1.2-1.4-0.1-1.4-1.0-0.9-1.1-1.5-1.2
Intermittent access standard deviation0.61.32.50.1-0.9-1.1-0.9-1.5-1.6-1.2-1.6-0.7
Left kidney weight1.15.37.9-1.8-2.5-1.0-2.7-2.8-2.8-1.5-2.7-2.3
Right kidney weight2.19.713.7-2.8-3.6-1.2-3.7-3.6-3.6-2.2-3.2-3.2
Cocaine induced anxiety0.40.62.2-1.5-0.71.2-0.40.20.11.1-0.2-0.5
Post-drug Anxiety0.20.20.6-0.7-0.50.4-0.3-0.2-0.20.3-0.8-0.5
Baseline Anxiety1.01.23.41.80.8-1.80.4-0.6-0.6-1.4-0.5-0.0
Tail length1.86.920.4-4.5-3.82.9-3.2-1.2-1.10.6-1.3-1.9
Length with tail3.615.940.0-6.3-5.62.8-5.3-2.8-2.7-0.4-2.8-3.6
Length without tail3.812.220.3-4.3-4.40.2-4.5-3.3-3.3-1.8-3.5-3.8
Times rat made contact with spout1.21.43.31.81.7-0.81.30.60.6-0.20.81.5
Lifetime Intake0.00.10.30.30.10.0-0.10.00.1-0.6-0.30.1
Liver weight, left3.96.412.2-3.4-3.51.1-3.2-2.3-2.3-0.3-2.3-2.6
Liver weight, right4.57.923.8-4.9-4.12.6-3.4-1.5-1.40.6-1.6-2.4
Locomotor activity0.20.31.2-0.4-0.50.8-0.1-0.1-0.11.1-0.1-0.1
Locomotor testing distance0.10.10.40.70.1-0.40.3-0.4-0.30.5-0.1-0.3
Locomotor testing rearing0.51.02.0-0.6-1.0-0.5-1.0-1.4-1.4-0.2-0.9-1.3
Locomotion in novel chamber0.10.10.40.30.20.30.20.20.20.40.7-0.1
Locomotion in novel chamber post-restriction0.71.22.40.2-0.5-1.5-0.6-1.2-1.2-1.6-0.9-1.2
Fecal boli incidents, locomotor time 10.40.61.1-0.2-0.5-0.7-0.8-1.0-0.9-1.1-0.5-1.0
Change in fecal boli incidents, locomotor task0.10.10.2-0.4-0.5-0.2-0.3-0.3-0.3-0.2-0.4-0.5
Time >=10cm from walls, locomotor time 14.54.76.7-1.9-2.4-1.1-2.3-2.4-2.4-1.4-2.5-2.6
Bouts of movement, locomotor time 10.20.20.7-0.9-0.40.6-0.10.10.10.80.2-0.1
Total resting periods, locomotor time 10.40.41.7-1.3-0.70.7-0.6-0.1-0.10.6-0.0-0.4
Rest time, locomotor task time 10.40.61.6-0.8-0.11.30.10.80.80.80.70.4
Distance moved, locomotor task time 10.50.71.20.3-0.4-1.0-0.5-1.0-1.0-0.9-1.1-0.8
Vertical activity count, locomotor time 11.74.07.0-0.4-1.6-1.7-1.8-2.7-2.6-1.9-2.4-1.9
Time >=10cm from walls, locomotor time 23.65.47.6-0.8-2.1-2.0-2.1-2.5-2.5-2.7-2.5-2.8
Bouts of movement, locomotor time 20.71.14.8-2.2-1.61.0-1.1-0.2-0.20.5-0.3-0.5
Total resting periods, locomotor time 20.71.35.2-2.3-1.41.6-0.80.30.31.00.3-0.1
Rest time, locomotor task time 20.91.13.6-1.9-1.11.6-0.50.30.31.3-0.0-0.5
Distance moved, locomotor task time 22.63.17.50.8-0.4-2.3-1.1-1.9-1.9-2.7-2.1-1.3
Vertical activity count, locomotor time 22.23.16.00.1-0.9-1.7-1.5-2.1-2.1-2.5-2.1-1.5
Light reinforcement 10.71.73.1-0.1-0.9-1.5-0.9-1.8-1.8-0.8-1.3-1.7
Light reinforcement 22.03.14.8-1.5-1.9-1.0-2.0-2.1-2.1-1.2-1.4-2.2
Bone: marrow area5.512.023.3-4.7-4.81.1-4.5-3.1-3.0-1.1-2.8-3.7
Bone: maximum diameter1.12.16.7-2.6-1.82.2-1.4-0.0-0.01.00.0-0.9
Bone: maximum force0.50.91.5-0.2-0.7-1.0-0.7-1.0-1.0-1.0-1.2-1.2
Bone: maximum moment0.40.61.2-0.3-0.8-0.6-0.7-0.8-0.8-0.9-0.9-1.1
Mean time between licks in bursts1.53.711.1-2.8-0.83.3-0.61.21.22.71.60.7
Mean num. licks in bursts0.61.02.81.71.2-1.50.80.0-0.0-1.10.20.6
Cd content in liver1.51.63.80.2-0.4-1.6-0.9-1.4-1.4-1.9-1.3-1.4
Co content in liver3.23.77.40.8-0.5-2.7-1.0-2.1-2.1-2.6-2.4-1.5
Cu content in liver2.73.18.02.82.5-1.12.31.31.30.11.31.6
Fe content in liver0.30.40.9-0.3-0.3-1.0-0.5-0.7-0.7-0.8-0.6-0.5
K content in liver1.11.11.9-0.50.61.30.41.01.11.41.41.1
Mg content in liver1.51.64.2-1.8-0.42.1-0.30.80.82.00.70.7
Mn content in liver3.03.312.7-3.6-1.82.7-1.70.10.11.90.2-0.5
Na content in liver1.11.22.31.01.30.11.20.90.91.01.31.5
Rb content in liver0.60.71.5-0.7-0.8-0.4-0.9-0.7-0.7-0.7-1.2-1.2
Se content in liver3.13.710.0-2.2-0.43.2-0.01.81.82.72.00.9
Sr content in liver0.50.51.3-0.1-0.5-0.5-0.7-0.7-0.7-1.1-0.6-0.9
Zn content in liver0.50.51.6-1.2-0.21.3-0.40.50.50.70.7-0.1
Bone: minimum diameter1.83.26.8-2.6-2.50.9-2.3-1.4-1.4-0.2-1.4-1.9
Time in familiar zone, hab. session 11.11.12.01.41.4-0.71.20.70.7-0.40.91.4
Time in novel zone, hab. session 10.40.41.0-0.7-0.80.6-0.6-0.3-0.30.4-0.3-1.0
Total zone transitions, hab. session 13.34.67.12.02.50.82.72.42.42.02.02.1
Total locomotion distance, hab. session 13.04.25.51.22.21.12.32.32.42.22.12.2
Locomotion velocity, hab. session 12.83.95.31.02.11.22.12.32.32.12.02.2
Time in familiar zone, hab. session 20.30.31.4-0.00.40.20.50.40.41.20.50.7
Time in novel zone, hab. session 21.01.02.8-0.1-0.8-0.5-1.0-0.9-0.9-1.7-1.1-1.1
Total zone transitions, hab. session 21.11.42.70.91.30.51.51.31.31.60.91.0
Total locomotion distance, hab. session 22.53.35.41.11.91.02.12.02.02.31.61.8
Locomotion velocity, hab. session 23.34.47.01.02.11.32.32.42.42.62.02.1
Novel to familiar place preference ratio0.30.31.21.10.7-0.60.60.20.2-0.50.30.3
Novelty place preference0.20.20.80.90.6-0.30.50.30.3-0.40.20.3
Time in novel zone, NPP test0.10.10.50.70.4-0.30.30.10.1-0.40.10.2
Total zone transitions, NPP test1.92.73.80.61.71.21.71.92.01.81.81.7
Total locomotion distance, NPP test0.81.12.30.81.50.21.31.21.20.71.01.0
Locomotion velocity, NPP test1.42.03.91.12.00.21.71.51.61.01.31.4
Intraocular pressure0.30.40.7-0.4-0.6-0.2-0.7-0.7-0.7-0.4-0.8-0.7
Delta distance traveled before/after self-admin0.40.40.7-0.4-0.80.0-0.9-0.7-0.7-0.5-0.8-0.4
Delta ambulatory time before/after self-admin0.50.61.2-0.8-1.10.1-1.0-0.7-0.7-0.3-0.9-0.6
Parametrial fat weight2.45.79.2-0.7-2.1-2.2-2.1-3.0-3.0-2.1-2.8-2.5
Pavlov. Cond. lever latency3.03.87.10.5-0.8-2.7-1.2-2.5-2.4-2.1-2.5-1.5
Pavlov. Cond. magazine entry latency2.32.98.1-1.20.12.90.51.91.92.11.71.4
Pavlov. Cond. change in total contacts0.50.61.8-0.5-0.21.30.20.90.90.80.70.4
Pavlov. Cond. index score2.73.48.2-0.90.42.90.82.22.22.12.11.4
Pavlov. Cond. latency score2.63.27.7-1.00.32.80.72.12.12.12.21.4
Pavlov. Cond. lever contacts1.92.34.9-0.50.42.20.82.01.91.51.91.0
Pavlov. Cond. magazine entry number2.12.76.40.7-0.4-2.5-0.8-1.9-1.9-2.1-1.5-1.4
Pavlov. Cond. intertrial magazine entries1.01.24.51.30.7-2.10.2-0.6-0.6-1.7-0.8-0.3
Pavlov. Cond. lever-magazine prob. diff.2.83.47.7-0.70.62.81.02.32.32.12.11.5
Pavlov. Cond. response bias3.03.79.2-1.00.43.00.82.32.32.41.91.4
Pavlov. Cond. lever latency0.81.11.9-0.8-1.3-0.3-1.1-1.2-1.2-0.5-1.1-1.4
Pavlov. Cond. magazine entry latency0.81.02.0-1.4-1.40.3-1.4-0.9-0.9-0.8-0.6-0.9
Pavlov. Cond. change in total contacts0.10.20.80.30.60.00.40.50.5-0.00.60.9
Pavlov. Cond. index score0.10.10.2-0.4-0.10.4-0.20.30.2-0.10.30.3
Pavlov. Cond. latency score0.00.10.2-0.4-0.10.4-0.30.10.1-0.10.30.2
Pavlov. Cond. lever contacts0.60.91.50.91.20.01.01.01.00.40.81.2
Pavlov. Cond. magazine entry number0.50.71.00.60.80.31.00.90.90.90.80.7
Pavlov. Cond. intertrial magazine entries0.91.44.4-1.5-0.41.70.00.90.92.11.00.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.4-0.10.3-0.20.20.1-0.20.20.2
Pavlov. Cond. response bias0.30.40.80.00.50.50.40.80.80.30.60.9
Time in closed arm before self-admin0.00.00.1-0.2-0.20.1-0.10.00.0-0.2-0.3-0.3
Time in closed arm after self-admin0.70.71.91.41.1-0.90.90.60.6-0.60.70.4
Time in open arm before self-admin0.60.62.60.10.70.60.40.50.60.61.61.0
Time in open arm after self-admin0.50.52.0-1.1-0.61.4-0.50.10.10.70.00.4
Bone: periosteal estimation1.93.98.2-2.8-2.90.9-2.5-1.6-1.6-0.3-1.6-2.1
Bone: periosteal perimeter0.81.43.1-1.7-1.80.7-1.5-1.0-1.0-0.1-0.9-1.0
Bone: post-yield work1.62.45.1-2.3-2.20.9-2.0-1.1-1.1-0.2-1.0-1.8
Progressive ratio test 1 active lever presses0.10.10.70.40.1-0.3-0.2-0.2-0.1-0.8-0.4-0.2
Progressive ratio test 1 breakpoint0.10.10.50.40.1-0.2-0.1-0.1-0.0-0.7-0.3-0.2
Progressive ratio test 1 inactive lever presses0.30.41.51.00.3-1.20.1-0.6-0.6-0.7-0.2-0.3
Progressive ratio test 2 active lever presses0.10.10.30.60.4-0.20.30.20.3-0.40.40.3
Progressive ratio test 2 breakpoint0.10.20.40.60.4-0.20.40.20.3-0.50.40.4
Progressive ratio test 2 inactive lever presses0.10.20.5-0.6-0.20.7-0.20.50.5-0.10.40.1
Incentive Sensitization - Responses0.60.81.70.30.70.80.90.90.90.91.30.9
Incentive Sensitization - Breakpoint0.50.61.40.30.60.70.80.70.80.81.20.8
Sum of active levers in priming session hrs 5-60.10.10.10.20.20.20.20.30.30.20.10.4
Progressive ratio1.11.83.4-0.1-1.1-1.6-1.1-1.8-1.8-1.3-1.2-1.0
Food seeking constrained by brief footshock0.30.41.50.80.2-1.20.1-0.2-0.2-1.2-0.1-0.1
Seeking ratio, punishment vs. effort1.21.83.20.91.50.81.41.81.80.81.41.2
Retroperitoneal fat weight0.21.01.3-0.5-0.9-1.0-0.9-1.1-1.1-1.1-1.0-1.1
Reaction time number correct0.61.14.21.60.6-2.00.6-0.6-0.6-1.2-0.60.1
Reaction time mean minus median1.74.314.5-3.8-2.72.3-2.6-0.9-0.90.6-0.5-1.3
Reaction time mean minus median AUC1.43.612.0-3.5-2.51.8-2.6-1.0-1.0-0.1-0.4-1.4
Reaction time num false alarms0.71.03.2-1.1-0.21.70.10.70.71.80.60.6
Reaction time num false alarms AUC1.11.75.1-0.90.12.10.41.11.12.30.91.0
Reaction time trials correct on left0.61.14.21.60.6-2.00.6-0.6-0.6-1.2-0.60.1
Reaction time trials on left0.61.14.01.50.5-2.00.5-0.7-0.7-1.3-0.60.0
Reaction time mean2.64.19.8-3.1-2.71.3-2.8-1.6-1.6-0.5-1.2-2.0
Reaction time mean AUC2.84.59.7-3.1-2.91.0-2.9-1.8-1.8-0.8-1.3-2.2
Median of all reaction times2.02.95.1-2.2-2.20.5-2.3-1.6-1.5-0.8-1.2-1.9
Reaction time omissions1.42.15.6-2.4-1.91.5-1.7-0.9-0.90.6-0.8-1.2
Reaction time false alarm rate2.23.09.4-1.5-0.13.10.21.51.52.81.41.1
Reaction time premature initiation rate0.00.10.20.20.1-0.1-0.2-0.4-0.4-0.1-0.0-0.4
Reaction time premature initiations0.40.72.11.00.3-1.5-0.1-1.0-1.0-1.0-0.5-0.5
Std. dev. reaction times2.75.016.0-4.0-3.02.5-2.9-1.1-1.00.5-0.7-1.5
Reaction time trials completed0.61.14.01.50.5-2.00.5-0.7-0.7-1.3-0.60.0
Reaction time trials AUC0.61.14.21.40.5-2.00.4-0.7-0.7-1.3-0.7-0.0
Run reversals in cocaine runway, females0.40.41.11.10.6-0.70.3-0.10.0-1.0-0.2-0.0
Run reversals in cocaine runway, males1.31.33.8-2.0-1.31.9-1.00.20.21.0-0.1-0.5
Latency to leave start box in cocaine runway0.30.40.70.50.80.20.70.70.70.40.50.6
Latency to leave start box in cocaine runway, F0.10.20.30.40.60.00.50.40.50.40.40.3
Latency to leave start box in cocaine runway, M0.10.10.30.30.40.10.40.40.4-0.00.20.5
Std. dev. time between licks in bursts2.23.09.5-2.2-0.63.1-0.41.21.22.51.80.5
Total sessions with >9 infusions0.00.00.10.0-0.10.1-0.10.10.1-0.2-0.20.1
Short access day 1 total inactive lever presses0.50.62.1-1.4-1.11.0-0.9-0.00.0-0.20.5-0.7
Short access day 10 total inactive lever presses0.41.03.9-0.00.40.81.00.80.72.01.00.8
Short access day 1 total infusions0.10.10.5-0.10.00.7-0.00.40.40.10.30.2
Short access day 10 total infusions0.00.00.10.2-0.0-0.1-0.0-0.1-0.1-0.1-0.30.1
Short access total infusions0.00.00.30.30.0-0.1-0.1-0.00.0-0.5-0.2-0.0
Short access day 1 locomotion0.40.51.00.10.50.60.70.70.71.00.80.7
Short access day 10 total locomotion0.40.82.1-1.5-1.01.3-0.5-0.0-0.01.1-0.4-0.7
Short access total locomotion0.20.30.7-0.9-0.70.4-0.4-0.2-0.10.3-0.5-0.6
One hour access (0.3 mA shock)1.72.03.40.41.11.51.31.61.71.81.41.3
Compulsive drug intake0.80.93.9-0.8-0.21.40.20.50.52.01.2-0.0
One hour access (shock baseline)0.10.20.30.20.30.20.20.50.5-0.4-0.30.5
Social response proportion0.20.20.6-0.8-0.50.5-0.6-0.2-0.20.3-0.4-0.4
Social responses0.10.20.6-0.7-0.40.4-0.3-0.2-0.10.70.1-0.2
Social time1.92.57.1-2.5-1.42.5-0.80.30.32.70.6-0.4
Soleus weight2.67.525.8-5.1-3.44.0-2.9-0.2-0.21.80.0-1.7
Bone: stiffness0.40.71.30.0-0.4-1.1-0.5-1.0-1.0-0.6-1.1-0.9
Tibialis anterior weight0.10.30.80.50.90.10.70.40.40.60.80.6
Time to tail flick, vehicle, before self-admin0.30.31.1-1.0-0.70.2-0.0-0.0-0.10.9-0.7-0.1
Time to tail flick, vehicle, after self-admin0.20.20.8-0.9-0.70.5-0.6-0.2-0.2-0.0-0.4-0.5
Time to tail flick, test, before self-admin0.80.81.20.71.00.21.00.80.81.01.11.0
Time to tail flick, test, after self-admin0.60.61.1-0.40.30.70.51.01.00.71.01.0
Delta time to tail flick, vehicle, before/after SA0.40.41.41.20.8-0.60.30.10.1-1.10.30.2
Delta time to tail flick, test, before/after SA0.10.10.40.30.1-0.50.2-0.0-0.0-0.6-0.20.1
Tibia length2.46.513.8-3.4-3.70.8-3.2-2.3-2.3-0.3-1.9-2.9
Ambulatory time before self-admin0.10.20.3-0.5-0.40.5-0.2-0.2-0.20.60.5-0.2
Ambulatory time after self-admin0.70.82.0-1.2-1.40.6-1.1-0.9-0.90.4-0.4-0.8
Bone: tissue strength0.60.61.60.4-0.4-0.8-0.3-0.6-0.6-1.3-0.8-1.3
Total heroin consumption0.20.20.9-0.5-0.40.70.00.00.00.90.50.0
Bone: trabecular number0.30.51.10.81.0-0.30.90.50.60.30.90.5
Bone: trabecular spacing1.21.72.4-1.0-1.6-0.4-1.5-1.4-1.4-1.1-1.4-1.2
Bone: trabecular thickness0.20.20.4-0.4-0.3-0.5-0.6-0.7-0.6-0.4-0.1-0.5
Bone: trabecular tissue density0.20.31.0-0.5-0.31.0-0.20.40.40.40.50.6
Water consumed over 24 hours0.00.10.30.0-0.10.6-0.2-0.2-0.10.2-0.1-0.3
Number of responses in last shaping day1.11.22.7-0.00.61.70.51.41.40.71.51.0