Spdef

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Spdef	0.12	0.07	1.5e-03	0.04	0.04	0.04	0.04	1.4e-05	4.8e-05	8.4e-06	1.0e-05
2	NAcc	gene expression	Spdef	0.15	0.06	3.7e-14	0.04	0.08	0.09	0.09	1.5e-06	5.0e-12	6.2e-14	3.7e-13
3	Eye	gene expression	Spdef	0.45	0.17	2.2e-03	0.05	0.01	0	0.12	5.8e-02	2.0e-01	2.9e-01	8.1e-03
4	Brain	gene expression	Spdef	0.32	0.1	0.0e+00	0.14	0.18	0.19	0.19	2.9e-13	3.3e-16	2.3e-17	2.5e-17
5	IC	gene expression	Spdef	0.34	0.13	2.7e-08	0.19	0.14	0.16	0.18	1.9e-08	2.5e-06	2.2e-07	3.8e-08
6	PL	gene expression	Spdef	0.25	0.08	0.0e+00	0.21	0.2	0.22	0.22	2.5e-22	6.0e-22	1.9e-23	1.6e-23
7	RMTg	gene expression	Spdef	0.25	0.12	5.9e-05	0.14	0.16	0.16	0.16	1.2e-04	6.5e-05	6.1e-05	4.2e-05
8	BLA	gene expression	Spdef	0.18	0.08	7.4e-07	0.12	0.09	0.1	0.1	5.5e-07	1.9e-05	1.0e-05	5.5e-06
9	pVTA	gene expression	Spdef	0.13	0.05	5.1e-09	0.09	0.1	0.11	0.1	9.9e-08	8.3e-09	6.6e-09	1.9e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.1	0.5	-0.5	-0.5	-0.3	-0.4	-0.1	0.1	0.1	-0.7	-0.1
Area under the delay curve	0.1	0.2	0.8	0.1	0.4	-0.4	0.5	0.4	-0.4	-0.9	-0.3	0.4
BMI with tail	1.1	3.9	11.4	-2.0	-0.1	-3.4	0.1	1.9	-2.0	-2.5	2.0	1.3
BMI without tail	0.3	1.7	3.4	-1.2	0.5	-1.9	0.3	1.4	-1.4	-1.7	1.6	0.9
Body weight	2.8	12.2	17.6	2.9	4.2	-1.1	4.1	3.9	-3.9	-2.6	3.8	3.7
Weight adjusted by age	0.8	2.3	4.0	1.8	1.9	0.2	2.0	1.2	-1.2	-1.0	1.6	1.8
Bone surface	0.3	0.6	1.7	1.3	0.8	1.0	0.8	0.2	-0.2	0.7	-0.3	0.6
Bone volume	0.1	0.1	0.3	0.5	0.4	0.2	0.5	0.3	-0.3	0.1	-0.3	0.4
Breakpoint value in progressive ratio session	0.3	0.6	1.4	0.2	0.7	-0.6	0.7	1.2	-1.2	-0.3	-0.3	0.8
Number of licking bursts	0.2	0.6	2.1	0.7	0.1	1.5	-0.1	-0.6	0.6	1.4	-0.4	-0.4
Context. condit. distance diff. score	1.3	1.5	4.9	1.6	0.4	2.2	0.2	-0.9	0.9	1.7	-1.1	-0.4
Locomotion velocity, session 1	1.1	1.3	3.2	0.4	-0.5	1.8	-0.5	-1.3	1.3	1.3	-1.5	-0.8
Locomotion distance, session 1	2.9	3.8	5.2	-1.3	-2.3	0.8	-2.2	-2.3	2.3	1.7	-2.1	-1.9
Locomotion velocity, session 2	0.6	0.7	1.7	0.9	0.0	1.3	-0.1	-0.8	0.8	1.3	-0.9	-0.5
Locomotion distance, session 2	0.7	1.0	1.6	-0.4	-1.1	0.6	-1.1	-1.3	1.3	0.9	-1.1	-0.8
Locomotion velocity, session 3	1.3	1.5	2.3	-0.9	-1.2	0.6	-1.4	-1.4	1.4	1.1	-1.2	-1.5
Locomotion distance, session 3	2.7	3.1	4.7	-1.5	-1.9	0.7	-2.2	-2.1	2.1	1.4	-1.8	-1.8
Stereotopy head waving bouts, day 3	1.3	1.6	3.8	1.9	1.9	1.1	1.6	0.8	-0.8	0.2	0.9	1.1
Stereotopy head waving duration, day 3	0.4	0.5	1.6	1.3	1.0	1.0	0.9	0.2	-0.2	0.2	0.2	0.3
Locomotion velocity, session 7	0.8	0.9	2.2	-0.6	-1.1	0.4	-1.0	-1.1	1.1	0.3	-1.5	-0.8
Locomotion distance, session 7	1.8	2.3	4.4	-0.7	-1.6	0.6	-1.5	-1.8	1.8	0.8	-2.1	-1.9
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	-0.6	-0.3	0.4	-0.5	-0.4	0.4	0.4	-0.3	-0.8
Stereotopy head waving duration, day 7	0.0	0.0	0.2	-0.4	0.1	0.2	-0.1	0.0	-0.0	0.1	0.2	-0.0
Locomotion velocity, session 8	2.0	2.5	7.4	2.7	1.5	2.7	1.3	-0.2	0.2	1.6	-1.0	0.2
Locomotion distance, session 8	1.6	2.3	4.3	0.9	-0.6	2.0	-0.7	-1.7	1.7	2.1	-1.8	-1.0
Degree of sensitization distance	1.4	1.5	3.7	1.9	1.6	0.1	1.8	1.2	-1.2	-0.6	0.7	0.9
Degree of sensitization stereotypy	1.2	1.3	2.0	-1.4	-1.3	0.3	-1.4	-1.1	1.1	0.7	-1.0	-1.4
Conditioned locomotion	2.7	3.2	5.0	1.8	2.1	-0.7	2.2	2.0	-2.1	-0.9	1.8	1.7
Cocaine response after cond. corrected	0.3	0.5	1.1	0.1	0.4	-0.7	0.5	0.8	-0.8	-0.4	1.1	0.9
Cocaine response after cond. not corrected	0.4	0.5	0.9	0.8	0.9	0.3	0.8	0.6	-0.6	0.2	1.0	0.8
Cocaine response before conditioning	0.8	0.9	3.3	1.4	1.1	1.8	0.6	-0.4	0.4	1.1	-0.1	0.1
Saline control response	1.7	2.4	4.9	-1.0	0.4	-2.2	0.6	1.7	-1.7	-2.1	2.1	0.7
Bone: connectivity density	0.1	0.1	0.4	0.3	0.1	0.2	0.3	0.2	-0.2	0.1	-0.2	0.6
Bone: cortical apparent density	0.5	0.7	2.3	-1.4	-0.7	-1.5	-0.7	0.3	-0.3	-0.7	0.9	0.2
Bone: cortical area	0.1	0.1	0.2	-0.2	-0.1	0.3	-0.4	-0.4	0.4	0.4	-0.1	-0.1
Bone: cortical porosity	1.2	1.3	3.4	-0.6	-1.0	0.6	-0.9	-1.2	1.2	0.3	-1.8	-1.9
Bone: cortical porosity	0.6	0.7	1.8	0.1	-0.3	0.9	-0.3	-0.9	0.9	0.2	-1.3	-1.2
Bone: cortical thickness	2.2	3.7	10.9	-3.3	-2.6	-1.4	-2.7	-1.4	1.4	0.2	-0.8	-1.5
Bone: cortical thickness	1.4	1.7	5.7	-2.2	-1.3	-2.4	-1.1	0.3	-0.3	-0.9	0.6	-0.5
Bone: cortical tissue density	0.4	0.6	1.8	-1.1	-0.5	-1.4	-0.5	0.4	-0.4	-0.6	0.9	0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.0	-0.1	0.0	-0.2	-0.5	0.5	-0.3	-0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.9	-0.1	0.4	-1.0	0.4	0.6	-0.6	-0.9	0.8	0.5
Condit. Reinf. active responses	0.1	0.1	0.5	-0.1	0.0	-0.5	0.0	-0.1	0.1	-0.7	0.2	0.2
Condit. Reinf. inactive responses	0.2	0.3	0.7	-0.8	-0.7	-0.8	-0.6	-0.3	0.3	-0.4	-0.1	-0.3
Incentive salience index mean	0.2	0.3	0.6	0.7	0.2	0.8	-0.0	-0.7	0.7	0.3	-0.5	-0.0
Condit. Reinf. lever presses	0.4	0.6	1.8	1.2	0.6	1.3	0.3	-0.6	0.6	0.8	-0.5	0.3
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	0.7	0.1	0.8	0.0	-0.6	0.6	0.4	-0.6	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.7	0.9	0.5	0.8	0.3	-0.4	0.3	0.2	-0.2	-0.0
Condit. Reinf. active responses	0.2	0.3	0.7	0.5	-0.2	0.6	-0.1	-0.7	0.6	0.6	-0.8	-0.7
Condit. Reinf. inactive responses	0.0	0.0	0.2	-0.1	-0.3	-0.3	-0.0	0.1	-0.1	0.1	-0.2	-0.4
Condit. Reinf. lever presses	0.8	1.1	2.2	-0.4	-1.0	0.8	-0.9	-1.3	1.3	0.9	-1.2	-1.5
Condit. Reinf. lever reinforcers received	0.5	0.7	1.2	0.3	-0.5	0.8	-0.5	-1.1	1.0	0.9	-1.0	-1.0
Conditioned reinforcement - actives	0.0	0.1	0.1	-0.0	0.2	0.2	0.3	0.3	-0.3	-0.2	0.2	0.4
Conditioned reinforcement - inactives	0.1	0.3	0.4	-0.7	-0.6	0.1	-0.5	-0.6	0.6	0.0	-0.3	-0.6
Conditioned locomotion	0.6	0.9	1.6	0.8	1.0	-0.2	1.3	0.8	-0.8	-1.2	0.6	1.2
Patch foraging indifference point 0 sec	0.4	1.1	2.9	-1.3	-0.3	-1.7	0.0	1.2	-1.1	-1.0	1.4	0.3
Patch foraging indifference point AUC	0.4	1.1	3.0	1.2	0.5	1.7	-0.1	-1.1	1.0	1.6	-0.2	-0.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.4	0.5	0.0	0.4	0.1	-0.1	-0.4	0.1	0.4
Delay disc. indifference point, 16s delay	0.4	0.6	1.8	-1.3	-0.9	-0.5	-0.7	-0.4	0.4	-0.3	-0.8	-0.8
Delay disc. indifference point, 2s delay	0.3	0.4	1.1	1.0	0.6	0.5	0.8	0.2	-0.2	-0.5	-0.2	0.7
Delay disc. indifference point, 24s delay	0.3	0.5	1.8	-1.0	-0.2	-1.1	0.0	0.2	-0.2	-1.3	-0.4	-0.0
Delay disc. indifference point, 4s delay	0.7	0.7	1.5	0.9	1.2	-0.2	1.0	0.8	-0.8	-0.7	0.5	1.0
Delay disc. indifference point, 8s delay	0.2	0.3	1.2	0.2	0.5	-0.5	0.7	0.6	-0.6	-1.1	-0.1	0.3
Indifference point function ln k	0.2	0.6	2.2	-0.3	-0.7	0.8	-0.5	-0.4	0.5	0.8	-1.5	-0.8
Indifference point function log k	0.2	0.6	2.2	-0.3	-0.7	0.8	-0.5	-0.4	0.5	0.8	-1.5	-0.8
Patch foraging total patch changes 0 sec	0.4	1.2	3.2	-1.6	-0.6	-1.8	-0.3	0.9	-0.9	-1.0	1.3	0.1
Patch foraging total patch changes 12 sec	0.2	0.3	1.0	-1.0	-0.7	-0.3	-0.8	-0.3	0.3	0.5	0.0	-0.5
Patch foraging total patch changes 18 sec	0.5	1.1	3.5	-1.4	-0.6	-1.9	-0.4	0.8	-0.7	-0.8	1.6	-0.1
Patch foraging total patch changes 24 sec	0.4	1.5	4.2	-2.0	-1.6	-1.9	-1.3	-0.3	0.3	-0.6	0.6	-0.8
Patch foraging total patch changes 6 sec	0.7	1.2	3.8	-1.9	-1.2	-1.8	-0.9	0.1	-0.1	-1.0	0.8	-0.3
Patch foraging time to switch 0 sec	0.8	2.9	8.3	-1.0	0.1	-2.9	0.6	2.0	-2.0	-2.2	1.3	1.3
Patch foraging water rate 0 sec	0.1	0.2	0.9	-0.0	-0.1	0.9	-0.2	-0.5	0.5	0.6	0.5	-0.1
Patch foraging water rate 12 sec	0.5	1.8	3.3	-1.6	-1.7	-0.0	-1.8	-1.4	1.4	0.9	-0.7	-1.5
Patch foraging water rate 18 sec	0.1	0.3	0.9	-0.2	0.5	-0.3	0.3	0.5	-0.5	-0.6	1.0	0.5
Patch foraging water rate 24 sec	0.6	0.8	1.5	-1.0	-1.1	0.3	-1.2	-0.9	0.9	0.9	-0.8	-0.8
Patch foraging water rate 6 sec	0.5	0.7	1.2	-0.8	-1.1	0.3	-1.0	-0.9	0.9	0.9	-0.5	-1.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.3	0.3	0.1	0.1	0.3	-0.3	0.6	-0.2	-0.1
Distance traveled before self-admin	0.3	0.7	1.4	1.2	1.2	0.5	0.9	0.7	-0.7	0.5	0.2	0.9
Distance traveled after self-admin	0.9	1.6	3.3	1.7	1.8	0.6	1.5	1.3	-1.3	0.3	0.8	1.1
Extensor digitorum longus weight	0.4	1.6	5.4	2.3	1.2	2.1	1.1	-0.2	0.2	1.3	-0.3	0.5
Bone: elastic displacement	0.9	1.2	2.0	-1.4	-1.4	-0.0	-1.2	-1.0	1.0	-0.0	-1.3	-1.2
Bone: elastic work	0.2	0.3	0.8	-0.9	-0.6	-0.5	-0.5	-0.2	0.2	-0.6	-0.5	-0.1
Bone: endosteal estimation	4.7	11.6	22.6	4.7	4.8	1.3	4.5	2.9	-2.9	-1.0	2.7	3.5
Bone: endosteal perimeter	2.3	5.7	13.0	3.6	3.4	1.3	3.1	1.9	-1.9	-0.3	1.5	2.4
Epididymis fat weight	3.1	15.9	52.1	-7.2	-3.9	-6.8	-3.3	1.0	-1.0	-3.6	1.9	-0.3
Delta time in closed arm before/after self-admin	0.6	0.6	2.0	-0.8	-0.2	-1.4	0.2	0.7	-0.7	-1.2	-0.1	0.4
Delta time in open arm before/after self-admin	0.3	0.4	0.9	0.9	0.9	0.8	0.5	0.1	-0.1	0.2	0.8	0.3
Diff in mean of infusions in LGA sessions	0.1	0.2	0.5	-0.7	-0.5	-0.5	-0.4	0.0	-0.0	0.1	-0.5	0.1
Delay discount exponential model param	0.1	0.2	0.7	-0.1	-0.3	0.4	-0.4	-0.3	0.3	0.8	0.4	-0.3
Extinction: sum of active levers before priming	0.1	0.2	0.4	-0.4	-0.5	0.2	-0.6	-0.4	0.4	0.6	-0.5	-0.0
Active lever presses in extinction session 6	0.6	0.6	1.9	-0.9	-0.2	-1.3	0.1	0.5	-0.5	-1.4	0.3	0.2
Bone: final force	1.9	3.0	5.6	-0.3	0.9	-2.4	1.0	2.0	-2.0	-2.1	2.1	1.7
Bone: final moment	1.5	2.3	3.8	-0.2	0.9	-2.0	1.0	1.8	-1.7	-2.0	1.8	1.5
Food consumed during 24 hour testing period	2.0	3.9	6.5	1.5	2.0	-0.9	2.4	2.5	-2.5	-1.5	1.9	2.0
Glucose	1.4	2.2	7.6	2.4	1.5	2.8	1.2	-0.5	0.5	1.0	-0.5	0.7
Heart weight	0.5	0.8	1.8	-0.5	-0.9	1.1	-0.8	-1.3	1.4	0.5	-0.5	-0.6
Delay discount hyperbolic model param	0.1	0.1	0.4	-0.1	-0.2	0.1	-0.3	-0.1	0.1	0.6	0.6	-0.1
Intermittent access intake day 1-15 change	0.1	0.4	0.9	0.3	0.7	-0.7	0.6	0.9	-1.0	-0.5	0.3	0.5
Intermittent access intake escalation	0.1	0.7	1.4	-0.0	0.7	-1.2	0.6	1.1	-1.2	-1.0	0.5	0.4
Intermittent access intake escalation 2	0.4	0.7	1.8	1.3	1.3	0.5	1.1	0.7	-0.7	-0.4	0.1	0.7
Intermitt. access day 1 inactive lever presses	0.1	1.6	5.0	0.1	-0.7	1.4	-1.1	-1.2	1.2	2.2	-1.3	-0.9
Intermitt. access day 15 inactive lever presses	0.1	0.4	1.2	1.1	0.8	0.4	0.7	0.5	-0.4	0.2	0.7	0.6
Intermitt. access escalation Index	0.4	1.2	2.7	-0.5	-0.9	0.6	-1.4	-1.2	1.2	1.6	-1.3	-0.8
Intermittent access day 1 total infusions	0.1	0.4	0.6	-0.6	-0.7	0.8	-0.4	-0.7	0.8	0.1	-0.5	-0.6
Intermittent access day 15 total infusions	0.0	0.1	0.3	-0.5	-0.2	-0.3	-0.1	0.1	-0.1	-0.6	0.1	-0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	-0.6	-0.3	-0.1	-0.2	-0.2	0.2	-0.5	-0.0	-0.4
Intermittent access total infusions	0.1	0.1	0.1	-0.4	-0.3	0.3	-0.1	-0.3	0.4	-0.3	0.1	-0.4
Intermittent access day 1 locomotion	0.1	0.1	0.5	0.3	0.2	0.2	0.2	0.0	0.0	-0.2	0.7	0.3
Intermittent access day 15 total locomotion	0.8	3.0	3.9	1.3	1.9	-0.9	2.0	1.9	-1.8	-1.9	1.7	1.9
Intermittent access total locomotion	1.1	1.3	2.3	1.2	1.4	-0.1	1.4	1.0	-0.9	-1.1	1.5	1.2
Intermittent access standard deviation	0.3	1.3	2.5	-0.1	0.9	-1.1	0.9	1.5	-1.6	-1.2	1.6	0.7
Left kidney weight	0.7	5.3	7.9	1.8	2.5	-1.0	2.7	2.8	-2.8	-1.5	2.7	2.3
Right kidney weight	1.4	9.7	13.7	2.8	3.6	-1.2	3.7	3.6	-3.6	-2.2	3.2	3.2
Cocaine induced anxiety	0.2	0.6	2.2	1.5	0.7	1.2	0.4	-0.2	0.1	1.1	0.2	0.5
Post-drug Anxiety	0.2	0.2	0.6	0.7	0.5	0.4	0.3	0.2	-0.2	0.3	0.8	0.5
Baseline Anxiety	0.7	1.2	3.4	-1.8	-0.8	-1.8	-0.4	0.6	-0.6	-1.4	0.5	0.0
Tail length	1.3	6.9	20.4	4.5	3.8	3.0	3.2	1.2	-1.1	0.6	1.3	1.9
Length with tail	3.6	15.9	40.0	6.3	5.6	2.8	5.3	2.8	-2.7	-0.4	2.8	3.6
Length without tail	2.3	12.2	20.3	4.3	4.4	0.2	4.5	3.3	-3.3	-1.8	3.5	3.9
Times rat made contact with spout	1.2	1.4	3.3	-1.8	-1.7	-0.8	-1.3	-0.6	0.6	-0.2	-0.8	-1.5
Lifetime Intake	0.0	0.1	0.4	-0.3	-0.1	0.0	0.1	-0.0	0.1	-0.6	0.3	-0.1
Liver weight, left	3.7	6.4	12.2	3.4	3.5	1.1	3.2	2.3	-2.3	-0.3	2.3	2.6
Liver weight, right	4.5	7.9	23.8	4.9	4.1	2.6	3.4	1.5	-1.4	0.6	1.6	2.4
Locomotor activity	0.2	0.3	1.2	0.4	0.5	0.8	0.1	0.1	-0.1	1.1	0.1	0.1
Locomotor testing distance	0.1	0.1	0.4	-0.7	-0.1	-0.4	-0.3	0.4	-0.3	0.5	0.1	0.3
Locomotor testing rearing	0.3	1.0	2.0	0.6	1.0	-0.5	1.0	1.4	-1.4	-0.2	0.9	1.3
Locomotion in novel chamber	0.1	0.1	0.4	-0.3	-0.2	0.3	-0.2	-0.2	0.2	0.4	-0.7	0.1
Locomotion in novel chamber post-restriction	0.4	1.2	2.4	-0.2	0.5	-1.5	0.6	1.2	-1.2	-1.5	0.9	1.2
Fecal boli incidents, locomotor time 1	0.2	0.6	1.1	0.2	0.5	-0.7	0.8	1.0	-0.9	-1.1	0.5	1.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.5	-0.2	0.3	0.3	-0.3	-0.2	0.4	0.5
Time >=10cm from walls, locomotor time 1	3.8	4.7	6.7	1.9	2.4	-1.1	2.3	2.4	-2.4	-1.4	2.5	2.6
Bouts of movement, locomotor time 1	0.2	0.2	0.7	0.9	0.4	0.6	0.1	-0.1	0.1	0.8	-0.2	0.1
Total resting periods, locomotor time 1	0.4	0.4	1.7	1.3	0.7	0.7	0.6	0.1	-0.1	0.6	0.0	0.4
Rest time, locomotor task time 1	0.3	0.6	1.6	0.8	0.1	1.3	-0.1	-0.8	0.8	0.8	-0.7	-0.4
Distance moved, locomotor task time 1	0.2	0.7	1.2	-0.3	0.4	-1.0	0.5	1.0	-1.0	-0.9	1.1	0.8
Vertical activity count, locomotor time 1	0.6	4.0	7.0	0.4	1.6	-1.7	1.8	2.7	-2.6	-1.9	2.4	1.9
Time >=10cm from walls, locomotor time 2	1.9	5.4	7.6	0.8	2.1	-2.0	2.1	2.5	-2.5	-2.7	2.5	2.8
Bouts of movement, locomotor time 2	0.3	1.1	4.8	2.2	1.6	1.0	1.1	0.2	-0.2	0.5	0.3	0.5
Total resting periods, locomotor time 2	0.3	1.3	5.2	2.3	1.4	1.6	0.8	-0.3	0.3	1.0	-0.3	0.1
Rest time, locomotor task time 2	0.6	1.1	3.6	1.9	1.1	1.6	0.5	-0.3	0.3	1.3	0.0	0.5
Distance moved, locomotor task time 2	2.4	3.1	7.5	-0.8	0.4	-2.3	1.1	1.9	-1.9	-2.7	2.1	1.3
Vertical activity count, locomotor time 2	1.3	3.1	6.1	-0.1	0.9	-1.7	1.5	2.1	-2.1	-2.5	2.1	1.5
Light reinforcement 1	0.4	1.7	3.1	0.1	0.9	-1.5	0.9	1.8	-1.8	-0.8	1.3	1.7
Light reinforcement 2	1.4	3.1	4.8	1.5	1.9	-1.0	2.0	2.1	-2.1	-1.2	1.4	2.2
Bone: marrow area	4.9	12.0	23.2	4.7	4.8	1.1	4.5	3.1	-3.0	-1.1	2.8	3.7
Bone: maximum diameter	1.0	2.1	6.7	2.6	1.8	2.2	1.4	0.0	-0.0	1.0	-0.0	0.9
Bone: maximum force	0.5	0.9	1.5	0.2	0.7	-1.0	0.7	1.0	-1.0	-1.0	1.2	1.2
Bone: maximum moment	0.3	0.6	1.2	0.3	0.8	-0.6	0.7	0.8	-0.8	-0.9	0.9	1.1
Mean time between licks in bursts	0.6	3.7	11.1	2.8	0.8	3.3	0.6	-1.2	1.2	2.7	-1.6	-0.7
Mean num. licks in bursts	0.4	1.0	2.8	-1.7	-1.2	-1.5	-0.8	-0.0	-0.0	-1.1	-0.2	-0.6
Cd content in liver	1.5	1.7	3.8	-0.2	0.4	-1.6	0.9	1.4	-1.4	-1.9	1.3	1.4
Co content in liver	3.1	3.7	7.4	-0.8	0.5	-2.7	1.0	2.1	-2.1	-2.6	2.4	1.5
Cu content in liver	2.7	3.2	8.0	-2.8	-2.5	-1.1	-2.3	-1.3	1.3	0.1	-1.3	-1.6
Fe content in liver	0.3	0.4	0.9	0.3	0.3	-1.0	0.5	0.7	-0.7	-0.8	0.6	0.5
K content in liver	1.1	1.1	1.9	0.5	-0.6	1.3	-0.4	-1.0	1.1	1.4	-1.4	-1.1
Mg content in liver	1.4	1.6	4.2	1.8	0.4	2.1	0.3	-0.8	0.8	2.0	-0.7	-0.7
Mn content in liver	2.9	3.3	12.7	3.6	1.8	2.7	1.7	-0.1	0.1	1.9	-0.2	0.5
Na content in liver	1.1	1.2	2.3	-1.0	-1.3	0.1	-1.2	-0.9	0.9	1.0	-1.3	-1.5
Rb content in liver	0.6	0.7	1.5	0.7	0.8	-0.4	0.9	0.7	-0.7	-0.7	1.2	1.2
Se content in liver	3.1	3.7	10.0	2.2	0.4	3.2	0.0	-1.8	1.8	2.6	-2.0	-0.9
Sr content in liver	0.6	0.5	1.3	0.1	0.5	-0.5	0.7	0.7	-0.7	-1.1	0.6	0.9
Zn content in liver	0.5	0.5	1.6	1.2	0.2	1.3	0.4	-0.5	0.5	0.7	-0.7	0.1
Bone: minimum diameter	1.7	3.2	6.8	2.6	2.5	1.0	2.3	1.4	-1.4	-0.2	1.4	1.9
Time in familiar zone, hab. session 1	1.0	1.1	2.0	-1.4	-1.4	-0.7	-1.2	-0.7	0.7	-0.4	-0.9	-1.4
Time in novel zone, hab. session 1	0.3	0.4	1.0	0.7	0.8	0.6	0.6	0.3	-0.3	0.4	0.3	1.0
Total zone transitions, hab. session 1	3.3	4.7	7.1	-2.0	-2.5	0.8	-2.7	-2.4	2.4	2.0	-2.0	-2.1
Total locomotion distance, hab. session 1	3.0	4.2	5.5	-1.2	-2.2	1.1	-2.3	-2.3	2.4	2.2	-2.1	-2.2
Locomotion velocity, hab. session 1	2.8	3.9	5.3	-1.0	-2.1	1.2	-2.1	-2.3	2.3	2.1	-2.0	-2.2
Time in familiar zone, hab. session 2	0.3	0.3	1.4	0.0	-0.4	0.2	-0.5	-0.4	0.4	1.2	-0.5	-0.7
Time in novel zone, hab. session 2	0.9	1.0	2.9	0.1	0.8	-0.5	1.0	0.9	-0.9	-1.7	1.1	1.1
Total zone transitions, hab. session 2	1.1	1.4	2.7	-0.9	-1.3	0.5	-1.5	-1.3	1.3	1.6	-0.9	-1.0
Total locomotion distance, hab. session 2	2.5	3.3	5.4	-1.1	-1.9	1.0	-2.1	-2.0	2.0	2.3	-1.6	-1.8
Locomotion velocity, hab. session 2	3.3	4.4	7.0	-1.0	-2.1	1.3	-2.3	-2.4	2.4	2.7	-2.0	-2.1
Novel to familiar place preference ratio	0.3	0.3	1.2	-1.1	-0.7	-0.6	-0.6	-0.2	0.2	-0.5	-0.3	-0.3
Novelty place preference	0.2	0.2	0.8	-0.9	-0.6	-0.3	-0.5	-0.3	0.3	-0.4	-0.2	-0.3
Time in novel zone, NPP test	0.1	0.1	0.5	-0.7	-0.4	-0.3	-0.3	-0.1	0.1	-0.4	-0.1	-0.2
Total zone transitions, NPP test	1.8	2.7	3.8	-0.6	-1.7	1.2	-1.7	-1.9	2.0	1.8	-1.8	-1.7
Total locomotion distance, NPP test	0.8	1.1	2.3	-0.8	-1.5	0.2	-1.3	-1.2	1.2	0.7	-1.0	-1.0
Locomotion velocity, NPP test	1.4	2.0	3.9	-1.1	-2.0	0.2	-1.7	-1.5	1.6	1.0	-1.3	-1.4
Intraocular pressure	0.2	0.4	0.7	0.4	0.6	-0.2	0.7	0.7	-0.7	-0.4	0.8	0.7
Delta distance traveled before/after self-admin	0.4	0.4	0.7	0.4	0.8	0.0	0.9	0.7	-0.7	-0.5	0.8	0.4
Delta ambulatory time before/after self-admin	0.3	0.6	1.2	0.8	1.1	0.1	1.0	0.7	-0.7	-0.3	0.9	0.6
Parametrial fat weight	2.4	5.7	9.2	0.7	2.1	-2.2	2.1	3.0	-3.0	-2.1	2.8	2.5
Pavlov. Cond. lever latency	3.0	3.8	7.1	-0.5	0.8	-2.7	1.2	2.5	-2.4	-2.1	2.5	1.5
Pavlov. Cond. magazine entry latency	2.3	2.9	8.1	1.2	-0.1	2.9	-0.5	-1.9	1.9	2.1	-1.7	-1.4
Pavlov. Cond. change in total contacts	0.5	0.6	1.8	0.5	0.2	1.3	-0.2	-0.9	0.9	0.8	-0.7	-0.4
Pavlov. Cond. index score	2.7	3.4	8.2	0.9	-0.4	2.9	-0.8	-2.2	2.2	2.1	-2.1	-1.4
Pavlov. Cond. latency score	2.5	3.2	7.7	1.0	-0.3	2.8	-0.7	-2.1	2.1	2.1	-2.2	-1.4
Pavlov. Cond. lever contacts	1.9	2.3	4.9	0.5	-0.4	2.2	-0.8	-2.0	1.9	1.5	-1.9	-1.0
Pavlov. Cond. magazine entry number	2.1	2.7	6.4	-0.7	0.4	-2.5	0.8	1.9	-1.9	-2.1	1.5	1.4
Pavlov. Cond. intertrial magazine entries	1.0	1.2	4.5	-1.3	-0.7	-2.1	-0.2	0.6	-0.6	-1.7	0.8	0.3
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.4	7.7	0.7	-0.6	2.8	-1.0	-2.3	2.3	2.1	-2.1	-1.5
Pavlov. Cond. response bias	2.9	3.7	9.2	1.0	-0.4	3.0	-0.8	-2.3	2.3	2.4	-1.9	-1.4
Pavlov. Cond. lever latency	0.8	1.1	1.9	0.8	1.3	-0.3	1.1	1.2	-1.2	-0.5	1.1	1.4
Pavlov. Cond. magazine entry latency	0.7	1.0	2.0	1.4	1.4	0.3	1.4	0.9	-0.9	-0.8	0.6	0.9
Pavlov. Cond. change in total contacts	0.1	0.2	0.8	-0.3	-0.6	0.0	-0.4	-0.5	0.5	-0.0	-0.6	-0.9
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	0.1	0.4	0.2	-0.3	0.2	-0.1	-0.3	-0.3
Pavlov. Cond. latency score	0.0	0.1	0.2	0.4	0.1	0.4	0.3	-0.1	0.1	-0.1	-0.3	-0.2
Pavlov. Cond. lever contacts	0.6	0.9	1.5	-0.9	-1.2	0.0	-1.0	-1.0	1.0	0.4	-0.8	-1.2
Pavlov. Cond. magazine entry number	0.5	0.7	1.0	-0.6	-0.8	0.3	-1.0	-0.9	0.9	0.9	-0.8	-0.7
Pavlov. Cond. intertrial magazine entries	0.6	1.4	4.4	1.5	0.4	1.7	-0.0	-0.9	0.9	2.1	-1.0	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.4	0.1	0.3	0.2	-0.2	0.1	-0.2	-0.2	-0.2
Pavlov. Cond. response bias	0.3	0.4	0.8	-0.0	-0.5	0.5	-0.4	-0.8	0.8	0.3	-0.6	-0.9
Time in closed arm before self-admin	0.0	0.0	0.1	0.2	0.2	0.1	0.1	-0.0	0.0	-0.2	0.3	0.3
Time in closed arm after self-admin	0.6	0.7	1.9	-1.4	-1.1	-0.9	-0.9	-0.6	0.6	-0.6	-0.7	-0.4
Time in open arm before self-admin	0.5	0.6	2.6	-0.1	-0.7	0.6	-0.4	-0.5	0.6	0.6	-1.6	-1.0
Time in open arm after self-admin	0.5	0.5	2.0	1.1	0.6	1.4	0.5	-0.1	0.1	0.7	-0.0	-0.4
Bone: periosteal estimation	1.7	3.9	8.2	2.8	2.9	0.9	2.5	1.6	-1.6	-0.3	1.6	2.1
Bone: periosteal perimeter	0.7	1.4	3.1	1.7	1.8	0.7	1.5	1.0	-1.0	-0.1	0.9	1.0
Bone: post-yield work	1.4	2.4	5.1	2.3	2.2	0.9	2.0	1.1	-1.1	-0.2	1.0	1.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.7	-0.4	-0.1	-0.3	0.2	0.2	-0.1	-0.8	0.4	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.5	-0.4	-0.1	-0.2	0.1	0.1	-0.0	-0.7	0.3	0.2
Progressive ratio test 1 inactive lever presses	0.2	0.4	1.5	-1.0	-0.3	-1.2	-0.1	0.6	-0.6	-0.7	0.2	0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.6	-0.4	-0.2	-0.4	-0.2	0.3	-0.4	-0.4	-0.3
Progressive ratio test 2 breakpoint	0.1	0.2	0.4	-0.6	-0.4	-0.2	-0.4	-0.2	0.3	-0.5	-0.4	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	0.6	0.2	0.7	0.2	-0.5	0.5	-0.1	-0.4	-0.1
Incentive Sensitization - Responses	0.3	0.8	1.7	-0.3	-0.7	0.8	-0.9	-0.9	0.9	0.9	-1.3	-0.9
Incentive Sensitization - Breakpoint	0.3	0.6	1.4	-0.3	-0.6	0.7	-0.8	-0.7	0.8	0.8	-1.2	-0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.2	-0.2	0.2	-0.2	-0.3	0.3	0.2	-0.1	-0.4
Progressive ratio	0.6	1.8	3.4	0.1	1.1	-1.6	1.1	1.8	-1.8	-1.3	1.2	1.0
Food seeking constrained by brief footshock	0.3	0.4	1.5	-0.8	-0.2	-1.2	-0.1	0.2	-0.2	-1.2	0.1	0.1
Seeking ratio, punishment vs. effort	0.8	1.8	3.2	-0.9	-1.5	0.8	-1.4	-1.8	1.8	0.8	-1.4	-1.2
Retroperitoneal fat weight	0.2	1.0	1.3	0.5	0.9	-1.0	0.9	1.1	-1.1	-1.1	1.0	1.1
Reaction time number correct	0.3	1.1	4.2	-1.6	-0.6	-2.0	-0.6	0.6	-0.6	-1.2	0.6	-0.1
Reaction time mean minus median	0.7	4.3	14.5	3.8	2.7	2.3	2.6	0.9	-0.9	0.6	0.5	1.3
Reaction time mean minus median AUC	0.5	3.6	12.0	3.5	2.5	1.8	2.6	1.0	-1.0	-0.1	0.4	1.4
Reaction time num false alarms	0.6	1.0	3.2	1.1	0.2	1.7	-0.1	-0.7	0.7	1.8	-0.6	-0.6
Reaction time num false alarms AUC	0.7	1.7	5.1	0.9	-0.1	2.1	-0.4	-1.1	1.1	2.3	-0.9	-1.0
Reaction time trials correct on left	0.3	1.1	4.2	-1.6	-0.6	-2.0	-0.6	0.6	-0.6	-1.2	0.6	-0.1
Reaction time trials on left	0.3	1.1	4.0	-1.5	-0.5	-2.0	-0.5	0.7	-0.7	-1.3	0.6	-0.0
Reaction time mean	1.9	4.1	9.8	3.1	2.7	1.3	2.8	1.6	-1.6	-0.5	1.2	2.0
Reaction time mean AUC	1.9	4.5	9.7	3.1	2.9	1.0	2.9	1.8	-1.8	-0.8	1.3	2.2
Median of all reaction times	1.8	2.9	5.1	2.2	2.2	0.5	2.3	1.6	-1.5	-0.8	1.2	1.9
Reaction time omissions	1.3	2.1	5.6	2.4	1.9	1.5	1.7	0.9	-0.9	0.6	0.8	1.2
Reaction time false alarm rate	2.2	3.0	9.4	1.5	0.1	3.1	-0.2	-1.5	1.5	2.8	-1.4	-1.1
Reaction time premature initiation rate	0.0	0.1	0.2	-0.2	-0.1	-0.1	0.2	0.4	-0.4	-0.1	0.0	0.4
Reaction time premature initiations	0.2	0.7	2.1	-1.0	-0.3	-1.5	0.1	1.0	-1.0	-1.0	0.5	0.5
Std. dev. reaction times	1.5	5.0	16.0	4.0	3.0	2.5	2.9	1.1	-1.0	0.5	0.7	1.6
Reaction time trials completed	0.3	1.1	4.0	-1.5	-0.5	-2.0	-0.5	0.7	-0.7	-1.3	0.6	-0.0
Reaction time trials AUC	0.3	1.1	4.2	-1.4	-0.5	-2.0	-0.4	0.7	-0.7	-1.3	0.7	0.0
Run reversals in cocaine runway, females	0.3	0.4	1.1	-1.1	-0.6	-0.7	-0.3	0.1	0.0	-1.0	0.2	0.0
Run reversals in cocaine runway, males	1.2	1.3	3.8	2.0	1.3	1.9	1.0	-0.2	0.2	1.0	0.1	0.5
Latency to leave start box in cocaine runway	0.3	0.4	0.7	-0.5	-0.8	0.2	-0.7	-0.7	0.7	0.4	-0.5	-0.6
Latency to leave start box in cocaine runway, F	0.1	0.2	0.3	-0.4	-0.6	0.0	-0.5	-0.4	0.5	0.4	-0.4	-0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.3	-0.4	0.1	-0.4	-0.4	0.4	-0.0	-0.2	-0.5
Std. dev. time between licks in bursts	1.6	3.0	9.5	2.2	0.6	3.1	0.4	-1.2	1.2	2.5	-1.8	-0.5
Total sessions with >9 infusions	0.0	0.0	0.1	-0.0	0.1	0.1	0.1	-0.1	0.1	-0.2	0.2	-0.1
Short access day 1 total inactive lever presses	0.3	0.6	2.1	1.4	1.1	1.0	0.9	0.0	0.0	-0.2	-0.5	0.8
Short access day 10 total inactive lever presses	0.1	1.0	4.0	0.0	-0.4	0.8	-1.0	-0.8	0.7	2.0	-1.0	-0.8
Short access day 1 total infusions	0.1	0.1	0.5	0.1	-0.0	0.7	0.0	-0.4	0.4	0.1	-0.3	-0.2
Short access day 10 total infusions	0.0	0.0	0.1	-0.2	0.0	-0.1	0.0	0.1	-0.1	-0.1	0.3	-0.1
Short access total infusions	0.0	0.0	0.3	-0.3	-0.0	-0.1	0.1	0.0	0.0	-0.5	0.2	0.0
Short access day 1 locomotion	0.3	0.5	1.0	-0.1	-0.5	0.6	-0.7	-0.7	0.7	1.0	-0.8	-0.7
Short access day 10 total locomotion	0.2	0.8	2.1	1.5	1.0	1.3	0.5	0.0	-0.0	1.1	0.4	0.7
Short access total locomotion	0.2	0.3	0.7	0.9	0.7	0.4	0.4	0.2	-0.1	0.3	0.5	0.6
One hour access (0.3 mA shock)	1.7	2.0	3.4	-0.4	-1.1	1.5	-1.3	-1.6	1.7	1.8	-1.4	-1.3
Compulsive drug intake	0.6	0.9	3.8	0.8	0.2	1.4	-0.2	-0.5	0.5	2.0	-1.2	0.0
One hour access (shock baseline)	0.1	0.2	0.3	-0.2	-0.3	0.2	-0.2	-0.5	0.5	-0.4	0.3	-0.5
Social response proportion	0.2	0.2	0.6	0.8	0.5	0.5	0.6	0.2	-0.2	0.3	0.4	0.4
Social responses	0.1	0.2	0.6	0.7	0.4	0.4	0.3	0.2	-0.1	0.7	-0.1	0.2
Social time	1.6	2.5	7.2	2.5	1.4	2.5	0.8	-0.3	0.3	2.7	-0.6	0.4
Soleus weight	2.6	7.5	25.8	5.1	3.4	4.0	2.9	0.2	-0.2	1.8	-0.0	1.7
Bone: stiffness	0.4	0.7	1.3	-0.0	0.4	-1.1	0.5	1.0	-1.0	-0.6	1.1	0.9
Tibialis anterior weight	0.1	0.3	0.8	-0.5	-0.9	0.0	-0.7	-0.4	0.4	0.6	-0.8	-0.6
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.1	1.0	0.7	0.2	0.0	0.0	-0.1	0.9	0.7	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.8	0.9	0.7	0.5	0.6	0.2	-0.2	-0.0	0.4	0.5
Time to tail flick, test, before self-admin	0.7	0.8	1.2	-0.7	-1.0	0.2	-1.0	-0.8	0.8	1.0	-1.1	-1.0
Time to tail flick, test, after self-admin	0.6	0.6	1.1	0.4	-0.3	0.7	-0.5	-1.0	1.0	0.7	-1.0	-1.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.4	-1.2	-0.8	-0.6	-0.3	-0.1	0.1	-1.1	-0.3	-0.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.4	-0.3	-0.1	-0.5	-0.2	0.0	-0.0	-0.6	0.2	-0.1
Tibia length	2.3	6.5	13.8	3.4	3.7	0.8	3.2	2.3	-2.3	-0.3	1.9	2.9
Ambulatory time before self-admin	0.1	0.2	0.3	0.5	0.4	0.5	0.2	0.2	-0.2	0.6	-0.5	0.2
Ambulatory time after self-admin	0.5	0.8	2.0	1.2	1.4	0.6	1.1	0.9	-0.9	0.4	0.4	0.8
Bone: tissue strength	0.6	0.6	1.6	-0.4	0.4	-0.8	0.3	0.6	-0.6	-1.3	0.8	1.3
Total heroin consumption	0.2	0.2	0.9	0.5	0.4	0.7	-0.0	-0.0	0.0	0.9	-0.5	-0.0
Bone: trabecular number	0.3	0.5	1.1	-0.8	-1.0	-0.3	-0.9	-0.5	0.6	0.3	-0.9	-0.5
Bone: trabecular spacing	1.1	1.7	2.4	1.0	1.6	-0.3	1.5	1.4	-1.4	-1.1	1.4	1.3
Bone: trabecular thickness	0.2	0.2	0.4	0.4	0.3	-0.5	0.6	0.7	-0.6	-0.4	0.1	0.5
Bone: trabecular tissue density	0.2	0.3	1.0	0.5	0.3	1.0	0.2	-0.4	0.4	0.4	-0.5	-0.6
Water consumed over 24 hours	0.0	0.1	0.3	-0.0	0.1	0.6	0.2	0.2	-0.1	0.2	0.1	0.3
Number of responses in last shaping day	0.9	1.2	2.7	0.0	-0.6	1.7	-0.5	-1.4	1.4	0.7	-1.5	-1.0