Spata31f3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Spata31f3 0.05 0.05 3.4e-05 0.04 0.04 0.04 0.03 8.6e-05 5.2e-05 5.0e-05 1.0e-04
2 BLA gene expression Spata31f3 0.07 0.05 2.4e-03 0.03 0.04 0.03 0.02 1.7e-02 3.1e-03 9.5e-03 2.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.91.52.5-1.60.7
Area under the delay curve0.00.00.10.3-0.0
BMI with tail1.85.89.7-3.11.4
BMI without tail6.513.517.8-4.23.0
Body weight3.213.417.3-4.23.1
Weight adjusted by age0.50.61.1-0.11.1
Bone surface0.91.61.9-1.41.2
Bone volume0.81.31.9-1.40.8
Breakpoint value in progressive ratio session0.30.30.60.20.8
Number of licking bursts3.64.35.7-2.41.7
Context. condit. distance diff. score0.20.20.3-0.3-0.5
Locomotion velocity, session 13.53.76.9-0.82.6
Locomotion distance, session 11.41.82.7-1.01.6
Locomotion velocity, session 21.71.93.2-1.80.8
Locomotion distance, session 23.34.74.8-2.12.2
Locomotion velocity, session 30.60.71.4-0.11.2
Locomotion distance, session 33.43.73.9-2.01.9
Stereotopy head waving bouts, day 30.81.01.21.10.8
Stereotopy head waving duration, day 31.01.22.41.50.2
Locomotion velocity, session 70.00.00.00.1-0.2
Locomotion distance, session 70.40.60.6-0.80.7
Stereotopy head waving bouts, day 71.92.12.5-1.31.6
Stereotopy head waving duration, day 70.50.61.1-0.31.1
Locomotion velocity, session 80.50.61.0-0.51.0
Locomotion distance, session 81.01.51.7-1.31.1
Degree of sensitization distance1.41.41.71.3-1.1
Degree of sensitization stereotypy0.91.01.0-1.01.0
Conditioned locomotion0.20.30.50.20.7
Cocaine response after cond. corrected1.11.22.41.60.3
Cocaine response after cond. not corrected1.01.11.91.40.6
Cocaine response before conditioning0.50.60.8-0.90.7
Saline control response1.92.53.6-1.21.9
Bone: connectivity density0.20.40.7-0.80.2
Bone: cortical apparent density0.70.91.60.3-1.3
Bone: cortical area2.33.46.1-2.50.9
Bone: cortical porosity0.50.60.60.8-0.7
Bone: cortical porosity0.00.00.00.1-0.1
Bone: cortical thickness0.50.81.6-1.3-0.2
Bone: cortical thickness0.20.30.50.1-0.7
Bone: cortical tissue density0.70.91.60.5-1.3
Condit. Reinf. active minus inactive responses0.60.61.1-1.10.4
Condit. Reinf. active-inactive response ratio0.60.60.80.7-0.9
Condit. Reinf. active responses2.73.35.3-2.31.1
Condit. Reinf. inactive responses2.83.45.7-2.41.0
Incentive salience index mean4.65.67.4-2.71.9
Condit. Reinf. lever presses11.515.417.2-4.13.7
Condit. Reinf. active minus inactive responses0.40.50.6-0.80.6
Condit. Reinf. active-inactive response ratio0.10.10.1-0.3-0.1
Condit. Reinf. active responses1.72.32.8-1.71.4
Condit. Reinf. inactive responses1.62.02.9-1.71.1
Condit. Reinf. lever presses1.11.52.7-1.60.5
Condit. Reinf. lever reinforcers received1.92.73.4-1.81.5
Conditioned reinforcement - actives0.40.40.70.80.2
Conditioned reinforcement - inactives1.01.12.11.50.2
Conditioned locomotion0.20.20.4-0.00.6
Patch foraging indifference point 0 sec1.62.55.0-0.32.2
Patch foraging indifference point AUC8.29.412.1-3.52.6
Delay disc. indifference point, 0s delay0.70.81.41.2-0.4
Delay disc. indifference point, 16s delay0.30.30.50.70.3
Delay disc. indifference point, 2s delay0.10.10.1-0.1-0.4
Delay disc. indifference point, 24s delay0.10.10.10.1-0.3
Delay disc. indifference point, 4s delay0.00.00.0-0.0-0.2
Delay disc. indifference point, 8s delay0.20.20.4-0.60.1
Indifference point function ln k2.94.05.92.4-1.4
Indifference point function log k2.94.05.92.4-1.4
Patch foraging total patch changes 0 sec1.93.15.7-0.72.4
Patch foraging total patch changes 12 sec1.92.42.9-1.71.4
Patch foraging total patch changes 18 sec1.01.31.6-1.01.2
Patch foraging total patch changes 24 sec2.73.33.8-1.72.0
Patch foraging total patch changes 6 sec3.75.57.4-1.92.7
Patch foraging time to switch 0 sec3.55.55.82.4-2.3
Patch foraging water rate 0 sec3.04.85.0-2.22.2
Patch foraging water rate 12 sec0.10.20.3-0.00.6
Patch foraging water rate 18 sec0.10.20.4-0.6-0.0
Patch foraging water rate 24 sec0.30.50.90.2-1.0
Patch foraging water rate 6 sec0.50.71.0-0.71.0
Seeking ratio, delayed vs. immediate footshock3.23.75.7-2.41.3
Distance traveled before self-admin6.97.37.4-2.72.7
Distance traveled after self-admin0.30.30.4-0.60.5
Extensor digitorum longus weight4.015.917.8-4.23.7
Bone: elastic displacement5.46.16.82.3-2.6
Bone: elastic work4.05.17.91.5-2.8
Bone: endosteal estimation2.04.35.0-2.21.9
Bone: endosteal perimeter2.55.15.7-2.42.1
Epididymis fat weight0.81.81.9-1.41.3
Delta time in closed arm before/after self-admin1.71.63.1-1.80.3
Delta time in open arm before/after self-admin0.20.20.50.70.1
Diff in mean of infusions in LGA sessions0.10.10.2-0.4-0.3
Delay discount exponential model param0.00.00.0-0.2-0.0
Extinction: sum of active levers before priming1.21.21.41.2-1.0
Active lever presses in extinction session 60.20.20.20.5-0.4
Bone: final force1.21.92.6-1.61.1
Bone: final moment0.81.31.9-1.40.8
Food consumed during 24 hour testing period1.01.21.7-0.91.3
Glucose1.92.84.2-2.01.2
Heart weight1.01.51.5-1.21.2
Delay discount hyperbolic model param0.00.00.0-0.1-0.0
Intermittent access intake day 1-15 change0.60.61.2-1.1-0.2
Intermittent access intake escalation1.01.01.9-1.40.1
Intermittent access intake escalation 20.70.71.4-1.2-0.2
Intermitt. access day 1 inactive lever presses1.41.52.3-1.50.8
Intermitt. access day 15 inactive lever presses0.30.30.6-0.30.7
Intermitt. access escalation Index2.82.53.1-1.81.4
Intermittent access day 1 total infusions1.11.32.51.60.2
Intermittent access day 15 total infusions0.10.20.3-0.20.5
Intermittent access terminal intake (last 3 days)0.30.40.7-0.00.8
Intermittent access total infusions0.40.40.9-0.10.9
Intermittent access day 1 locomotion1.21.32.51.6-0.3
Intermittent access day 15 total locomotion0.90.91.61.3-0.5
Intermittent access total locomotion1.21.31.91.4-0.9
Intermittent access standard deviation0.10.10.2-0.40.2
Left kidney weight0.72.13.0-1.11.7
Right kidney weight0.10.40.7-0.10.9
Cocaine induced anxiety1.31.52.61.6-0.6
Post-drug Anxiety0.50.50.6-0.70.8
Baseline Anxiety1.41.52.9-1.70.4
Tail length3.29.811.5-3.42.9
Length with tail1.14.15.2-1.82.3
Length without tail0.41.01.71.3-0.4
Times rat made contact with spout0.10.20.3-0.50.1
Lifetime Intake1.11.22.40.21.5
Liver weight, left1.01.52.4-1.60.8
Liver weight, right0.00.10.10.30.1
Locomotor activity0.00.00.0-0.10.1
Locomotor testing distance0.20.30.50.40.7
Locomotor testing rearing0.71.12.0-0.41.4
Locomotion in novel chamber0.30.40.50.5-0.7
Locomotion in novel chamber post-restriction0.60.71.3-1.1-0.1
Fecal boli incidents, locomotor time 11.11.21.21.1-1.1
Change in fecal boli incidents, locomotor task2.52.32.4-1.51.5
Time >=10cm from walls, locomotor time 10.70.70.7-0.90.8
Bouts of movement, locomotor time 12.93.14.52.1-1.3
Total resting periods, locomotor time 13.94.35.32.3-1.8
Rest time, locomotor task time 14.24.66.71.6-2.6
Distance moved, locomotor task time 13.64.05.8-1.52.4
Vertical activity count, locomotor time 12.93.15.1-1.02.3
Time >=10cm from walls, locomotor time 20.30.30.4-0.60.4
Bouts of movement, locomotor time 20.30.30.3-0.60.5
Total resting periods, locomotor time 20.00.00.0-0.10.2
Rest time, locomotor task time 21.71.92.41.6-1.2
Distance moved, locomotor task time 20.30.30.7-0.80.2
Vertical activity count, locomotor time 20.80.91.0-1.00.9
Light reinforcement 13.46.19.7-1.63.1
Light reinforcement 22.73.76.8-0.72.6
Bone: marrow area2.04.35.4-2.31.8
Bone: maximum diameter2.95.38.2-2.91.5
Bone: maximum force2.44.25.9-2.41.6
Bone: maximum moment1.73.04.5-2.11.2
Mean time between licks in bursts0.20.30.30.4-0.6
Mean num. licks in bursts2.12.52.61.6-1.5
Cd content in liver0.60.71.4-1.20.2
Co content in liver1.21.42.71.7-0.3
Cu content in liver1.31.61.91.1-1.4
Fe content in liver1.11.32.60.21.6
K content in liver0.10.10.20.50.2
Mg content in liver0.30.30.40.6-0.4
Mn content in liver0.10.10.10.3-0.3
Na content in liver1.21.31.81.4-0.9
Rb content in liver2.93.65.22.3-1.4
Se content in liver1.31.52.8-1.70.6
Sr content in liver0.20.20.3-0.50.4
Zn content in liver0.20.20.3-0.4-0.5
Bone: minimum diameter0.10.20.3-0.5-0.5
Time in familiar zone, hab. session 12.62.44.10.8-2.0
Time in novel zone, hab. session 11.11.11.61.30.7
Total zone transitions, hab. session 10.10.20.3-0.6-0.0
Total locomotion distance, hab. session 10.50.71.2-1.1-0.5
Locomotion velocity, hab. session 11.52.24.3-2.10.3
Time in familiar zone, hab. session 21.61.62.80.7-1.7
Time in novel zone, hab. session 21.51.52.81.70.4
Total zone transitions, hab. session 21.11.41.8-1.01.4
Total locomotion distance, hab. session 21.01.32.0-1.40.8
Locomotion velocity, hab. session 21.41.83.0-1.70.8
Novel to familiar place preference ratio2.62.75.12.3-0.5
Novelty place preference3.73.86.82.6-0.9
Time in novel zone, NPP test4.85.09.03.0-1.0
Total zone transitions, NPP test1.52.12.6-1.31.6
Total locomotion distance, NPP test2.94.04.3-2.11.9
Locomotion velocity, NPP test3.85.36.9-2.61.9
Intraocular pressure3.14.34.7-2.22.0
Delta distance traveled before/after self-admin1.11.11.61.2-0.9
Delta ambulatory time before/after self-admin2.22.43.01.7-1.3
Parametrial fat weight0.61.11.4-1.20.9
Pavlov. Cond. lever latency7.08.99.43.1-2.9
Pavlov. Cond. magazine entry latency0.40.50.8-0.90.5
Pavlov. Cond. change in total contacts2.72.93.0-1.71.7
Pavlov. Cond. index score2.73.44.2-2.11.6
Pavlov. Cond. latency score2.43.13.7-1.91.6
Pavlov. Cond. lever contacts4.85.76.4-2.52.2
Pavlov. Cond. magazine entry number0.91.11.71.3-0.7
Pavlov. Cond. intertrial magazine entries0.20.20.3-0.60.2
Pavlov. Cond. lever-magazine prob. diff.2.12.63.6-1.91.3
Pavlov. Cond. response bias3.23.95.0-2.21.6
Pavlov. Cond. lever latency1.21.63.11.7-0.5
Pavlov. Cond. magazine entry latency0.60.70.70.8-0.8
Pavlov. Cond. change in total contacts0.40.50.6-0.8-0.7
Pavlov. Cond. index score0.20.20.3-0.4-0.6
Pavlov. Cond. latency score0.20.30.3-0.5-0.6
Pavlov. Cond. lever contacts0.60.81.5-1.20.4
Pavlov. Cond. magazine entry number0.40.40.90.10.9
Pavlov. Cond. intertrial magazine entries0.50.70.8-0.90.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.4-0.6
Pavlov. Cond. response bias0.20.20.4-0.7-0.1
Time in closed arm before self-admin2.22.52.81.7-1.5
Time in closed arm after self-admin0.30.40.60.3-0.8
Time in open arm before self-admin3.13.34.3-1.52.1
Time in open arm after self-admin1.71.82.7-1.01.7
Bone: periosteal estimation2.44.97.2-2.71.6
Bone: periosteal perimeter1.32.22.5-1.61.4
Bone: post-yield work2.12.93.1-1.61.7
Progressive ratio test 1 active lever presses0.90.91.20.81.1
Progressive ratio test 1 breakpoint0.80.81.40.51.2
Progressive ratio test 1 inactive lever presses1.71.93.7-0.31.9
Progressive ratio test 2 active lever presses1.11.21.41.21.0
Progressive ratio test 2 breakpoint1.01.21.71.30.8
Progressive ratio test 2 inactive lever presses0.40.50.80.50.9
Incentive Sensitization - Responses0.30.30.50.40.7
Incentive Sensitization - Breakpoint0.30.30.30.60.6
Sum of active levers in priming session hrs 5-62.22.13.61.9-0.8
Progressive ratio0.00.00.00.00.0
Food seeking constrained by brief footshock9.411.512.5-3.23.5
Seeking ratio, punishment vs. effort1.92.32.7-1.41.6
Retroperitoneal fat weight0.10.30.50.4-0.7
Reaction time number correct0.30.50.5-0.70.7
Reaction time mean minus median1.01.31.6-1.0-1.3
Reaction time mean minus median AUC0.70.91.4-1.2-0.6
Reaction time num false alarms0.30.50.60.8-0.5
Reaction time num false alarms AUC0.00.00.10.10.3
Reaction time trials correct on left0.30.50.5-0.70.7
Reaction time trials on left0.20.30.3-0.60.6
Reaction time mean2.02.95.30.7-2.3
Reaction time mean AUC2.63.46.10.9-2.5
Median of all reaction times2.73.65.31.4-2.3
Reaction time omissions1.31.71.91.2-1.4
Reaction time false alarm rate0.50.71.01.0-0.6
Reaction time premature initiation rate2.63.54.21.7-2.1
Reaction time premature initiations1.21.72.21.1-1.5
Std. dev. reaction times1.31.83.5-0.3-1.9
Reaction time trials completed0.20.30.3-0.60.6
Reaction time trials AUC0.20.30.4-0.60.6
Run reversals in cocaine runway, females0.30.30.4-0.4-0.6
Run reversals in cocaine runway, males0.10.00.10.1-0.3
Latency to leave start box in cocaine runway0.60.71.1-1.10.5
Latency to leave start box in cocaine runway, F0.10.10.3-0.50.2
Latency to leave start box in cocaine runway, M1.41.31.9-0.91.4
Std. dev. time between licks in bursts0.50.60.80.9-0.7
Total sessions with >9 infusions1.31.51.81.11.3
Short access day 1 total inactive lever presses3.13.44.1-1.62.0
Short access day 10 total inactive lever presses0.60.71.1-1.00.5
Short access day 1 total infusions2.52.75.40.02.3
Short access day 10 total infusions1.21.32.6-0.21.6
Short access total infusions1.61.83.00.81.7
Short access day 1 locomotion0.30.30.40.70.4
Short access day 10 total locomotion1.61.82.11.4-1.2
Short access total locomotion0.20.20.40.10.6
One hour access (0.3 mA shock)0.50.61.10.41.1
Compulsive drug intake0.30.30.4-0.70.4
One hour access (shock baseline)0.60.71.30.31.2
Social response proportion1.41.52.80.4-1.7
Social responses1.41.83.2-1.80.7
Social time0.00.00.1-0.30.1
Soleus weight0.51.63.1-0.21.8
Bone: stiffness3.35.27.1-2.71.8
Tibialis anterior weight7.726.529.4-5.44.9
Time to tail flick, vehicle, before self-admin1.71.81.91.4-1.3
Time to tail flick, vehicle, after self-admin0.10.10.10.30.2
Time to tail flick, test, before self-admin0.00.00.0-0.10.0
Time to tail flick, test, after self-admin0.40.40.7-0.9-0.3
Delta time to tail flick, vehicle, before/after SA0.30.30.4-0.30.6
Delta time to tail flick, test, before/after SA0.20.20.2-0.4-0.4
Tibia length0.30.91.90.01.4
Ambulatory time before self-admin5.96.16.7-2.32.6
Ambulatory time after self-admin0.30.30.5-0.40.7
Bone: tissue strength0.10.10.1-0.30.2
Total heroin consumption0.40.40.60.80.4
Bone: trabecular number0.60.91.6-1.30.4
Bone: trabecular spacing0.10.10.3-0.0-0.5
Bone: trabecular thickness0.20.20.20.4-0.5
Bone: trabecular tissue density2.83.95.2-2.31.6
Water consumed over 24 hours0.70.81.0-1.00.8
Number of responses in last shaping day2.12.24.0-0.62.0