Hub : Genes

Sox9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Sox9 0.15 0.06 2.2e-16 0.16 0.16 0.16 0.17 2.2e-14 5.3e-15 7.3e-15 4.9e-16
2 Brain mRNA stability Sox9 0.03 0.02 4.7e-03 0.02 0.03 0.01 0.01 4.0e-03 2.2e-03 1.8e-02 1.4e-02
3 PL gene expression Sox9 0.17 0.06 0.0e+00 0.17 0.17 0.17 0.17 5.0e-18 2.2e-18 1.3e-18 1.5e-18
4 pVTA gene expression Sox9 0.13 0.07 9.9e-06 0.14 0.11 0.08 0.11 1.9e-06 1.8e-05 1.9e-04 1.3e-05
5 NAcc gene expression Sox9 0.15 0.06 1.0e-13 0.1 0.12 0.12 0.13 1.3e-11 2.9e-14 4.2e-14 1.1e-14
6 BLA gene expression Sox9 0.31 0.1 2.3e-15 0.28 0.28 0.28 0.29 4.1e-15 2.3e-15 1.7e-15 5.4e-16
7 IL gene expression Sox9 0.22 0.1 7.5e-04 0.07 0.11 0.09 0.09 8.1e-03 1.7e-03 4.4e-03 3.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.10.10.3-0.30.00.10.5-0.1-0.20.4
Area under the delay curve0.91.01.71.11.3-1.2-0.61.00.70.6
BMI with tail1.13.57.1-2.3-2.72.11.7-1.5-1.2-1.2
BMI without tail0.40.71.7-0.5-1.20.6-0.1-0.8-0.8-1.3
Body weight1.66.78.7-2.9-2.92.62.5-2.4-2.3-2.3
Weight adjusted by age1.01.22.4-0.6-1.31.00.4-1.2-1.1-1.6
Bone surface0.40.62.70.51.6-0.7-0.0-0.4-0.90.3
Bone volume0.40.72.90.81.7-0.9-0.40.0-0.40.5
Breakpoint value in progressive ratio session0.30.30.90.60.1-0.5-0.90.60.60.3
Number of licking bursts6.27.310.43.03.0-3.1-3.22.42.11.9
Context. condit. distance diff. score0.30.41.1-0.7-1.10.90.2-0.5-0.2-0.3
Locomotion velocity, session 10.40.41.50.60.3-0.5-1.2-0.1-0.4-0.6
Locomotion distance, session 12.22.95.4-1.3-1.81.30.8-1.9-2.0-2.3
Locomotion velocity, session 20.40.41.0-0.3-0.60.3-0.1-0.8-0.9-1.0
Locomotion distance, session 22.94.07.9-1.4-2.01.40.8-2.4-2.4-2.8
Locomotion velocity, session 31.21.41.9-1.0-1.31.00.8-1.3-1.3-1.4
Locomotion distance, session 31.51.62.0-1.3-1.41.11.2-1.3-1.2-1.3
Stereotopy head waving bouts, day 30.30.41.3-0.20.1-0.10.60.70.71.2
Stereotopy head waving duration, day 30.40.51.30.10.6-0.40.20.80.81.1
Locomotion velocity, session 72.02.12.8-1.4-1.31.31.2-1.6-1.7-1.7
Locomotion distance, session 74.25.39.6-1.8-2.51.91.4-2.5-2.4-3.1
Stereotopy head waving bouts, day 70.30.41.6-0.50.20.20.60.40.41.3
Stereotopy head waving duration, day 71.82.26.70.51.5-0.9-0.31.61.62.6
Locomotion velocity, session 80.20.31.00.70.2-0.5-1.00.20.1-0.2
Locomotion distance, session 83.24.77.0-1.8-2.42.01.1-2.5-2.3-2.6
Degree of sensitization distance1.01.02.3-0.5-0.90.80.3-1.2-1.1-1.5
Degree of sensitization stereotypy0.30.31.3-0.30.20.10.50.40.51.1
Conditioned locomotion0.10.10.40.10.2-0.1-0.20.30.40.6
Cocaine response after cond. corrected1.31.43.30.90.4-0.9-0.81.51.81.5
Cocaine response after cond. not corrected0.20.20.60.4-0.1-0.4-0.50.60.80.3
Cocaine response before conditioning3.23.96.6-1.6-1.51.71.3-2.3-2.5-2.6
Saline control response2.53.25.1-1.5-1.31.81.4-2.2-2.3-1.9
Bone: connectivity density0.10.10.4-0.40.10.20.7-0.2-0.30.3
Bone: cortical apparent density0.20.31.4-0.4-1.20.40.20.00.2-0.3
Bone: cortical area5.07.511.4-3.3-2.23.03.4-2.7-2.6-1.6
Bone: cortical porosity0.20.20.5-0.20.70.40.4-0.4-0.60.1
Bone: cortical porosity0.10.20.90.10.90.10.2-0.2-0.40.1
Bone: cortical thickness15.325.236.0-6.0-5.65.86.0-4.2-3.7-3.0
Bone: cortical thickness4.85.59.7-2.9-2.52.83.1-1.8-1.5-1.0
Bone: cortical tissue density0.10.20.9-0.1-0.90.2-0.10.30.4-0.1
Condit. Reinf. active minus inactive responses1.41.62.1-1.3-1.51.41.3-1.2-1.0-1.2
Condit. Reinf. active-inactive response ratio0.50.51.0-0.8-1.00.90.6-0.6-0.3-0.4
Condit. Reinf. active responses1.62.03.1-1.4-1.71.51.4-1.3-1.1-1.3
Condit. Reinf. inactive responses1.01.21.9-0.9-1.10.91.0-1.2-1.2-1.4
Incentive salience index mean0.70.91.4-0.9-1.21.01.0-0.9-0.7-0.9
Condit. Reinf. lever presses0.91.21.8-0.9-1.30.90.8-1.2-1.0-1.3
Condit. Reinf. active minus inactive responses0.10.20.5-0.6-0.20.70.3-0.3-0.20.1
Condit. Reinf. active-inactive response ratio0.10.10.30.20.3-0.1-0.5-0.0-0.1-0.2
Condit. Reinf. active responses0.91.21.9-1.3-1.01.41.2-1.1-1.0-0.6
Condit. Reinf. inactive responses3.23.95.7-2.3-1.82.22.4-1.9-1.8-1.2
Condit. Reinf. lever presses1.01.41.9-1.0-0.81.11.0-1.4-1.4-1.4
Condit. Reinf. lever reinforcers received1.11.62.1-1.4-1.11.41.3-1.3-1.2-0.9
Conditioned reinforcement - actives0.20.20.60.40.4-0.3-0.10.50.70.8
Conditioned reinforcement - inactives1.31.52.0-1.2-1.11.31.4-1.4-1.2-0.9
Conditioned locomotion0.00.00.00.00.20.10.2-0.10.00.1
Patch foraging indifference point 0 sec3.76.06.5-2.5-2.52.52.3-2.5-2.3-2.3
Patch foraging indifference point AUC0.60.72.70.90.5-0.9-1.60.30.2-0.3
Delay disc. indifference point, 0s delay0.10.10.4-0.3-0.30.20.70.10.10.3
Delay disc. indifference point, 16s delay0.10.10.60.20.8-0.40.00.2-0.00.0
Delay disc. indifference point, 2s delay1.71.93.31.81.5-1.7-1.71.00.70.5
Delay disc. indifference point, 24s delay0.10.10.50.10.7-0.40.3-0.1-0.3-0.2
Delay disc. indifference point, 4s delay2.42.53.01.61.6-1.7-1.21.71.61.7
Delay disc. indifference point, 8s delay0.60.61.00.81.0-1.0-0.60.80.70.6
Indifference point function ln k2.43.36.0-2.3-1.92.22.4-1.4-1.2-0.8
Indifference point function log k2.43.36.0-2.3-1.92.22.4-1.4-1.2-0.8
Patch foraging total patch changes 0 sec3.96.36.9-2.6-2.62.62.4-2.6-2.4-2.4
Patch foraging total patch changes 12 sec2.83.64.9-1.8-1.71.71.5-2.2-2.2-2.2
Patch foraging total patch changes 18 sec1.21.62.3-1.2-1.51.21.2-1.2-1.1-1.3
Patch foraging total patch changes 24 sec1.61.92.3-1.5-1.21.41.4-1.5-1.4-1.3
Patch foraging total patch changes 6 sec3.75.57.8-2.1-2.22.11.8-2.6-2.6-2.8
Patch foraging time to switch 0 sec0.60.91.61.31.1-1.1-1.00.70.50.5
Patch foraging water rate 0 sec0.71.11.3-1.1-1.11.11.0-1.2-0.9-0.9
Patch foraging water rate 12 sec0.40.61.4-0.8-1.00.91.2-0.4-0.1-0.0
Patch foraging water rate 18 sec0.60.81.6-1.2-0.81.11.3-0.6-0.20.0
Patch foraging water rate 24 sec3.95.48.1-2.8-2.72.72.8-1.9-1.5-1.2
Patch foraging water rate 6 sec1.11.62.9-1.2-1.71.41.2-1.1-0.9-1.0
Seeking ratio, delayed vs. immediate footshock0.00.10.1-0.30.40.10.0-0.2-0.20.2
Distance traveled before self-admin1.21.32.40.80.7-0.9-0.61.51.51.6
Distance traveled after self-admin0.70.81.00.90.8-1.0-0.91.01.00.7
Extensor digitorum longus weight0.00.10.6-0.1-0.80.00.00.10.2-0.3
Bone: elastic displacement4.85.47.9-2.8-2.62.62.6-2.0-1.9-1.5
Bone: elastic work7.710.014.3-3.8-3.23.53.7-2.9-2.7-1.9
Bone: endosteal estimation2.75.915.32.93.9-3.0-2.51.10.61.1
Bone: endosteal perimeter4.38.820.13.54.5-3.6-3.21.61.01.5
Epididymis fat weight3.58.212.2-2.6-2.92.42.2-3.1-3.2-3.5
Delta time in closed arm before/after self-admin0.00.00.10.20.3-0.1-0.1-0.1-0.1-0.3
Delta time in open arm before/after self-admin1.81.82.2-1.4-1.51.40.8-1.4-1.4-1.3
Diff in mean of infusions in LGA sessions0.40.40.90.40.2-0.5-0.50.80.90.8
Delay discount exponential model param1.31.42.3-1.3-1.51.40.8-1.2-0.9-0.8
Extinction: sum of active levers before priming1.11.11.6-1.1-1.31.10.9-1.0-0.9-0.9
Active lever presses in extinction session 60.30.31.00.60.5-0.6-1.00.30.20.2
Bone: final force4.47.210.4-3.1-2.23.03.2-2.7-2.6-1.6
Bone: final moment5.38.612.6-3.4-2.53.33.6-2.9-2.7-1.7
Food consumed during 24 hour testing period0.10.20.40.50.7-0.5-0.50.0-0.10.0
Glucose0.00.00.10.20.0-0.1-0.3-0.1-0.2-0.3
Heart weight5.67.910.6-3.1-2.22.83.3-2.9-2.9-2.4
Delay discount hyperbolic model param1.41.42.2-1.4-1.51.50.9-1.2-0.9-0.8
Intermittent access intake day 1-15 change0.60.61.10.80.4-0.8-1.00.80.80.8
Intermittent access intake escalation0.00.00.10.2-0.2-0.1-0.30.20.20.1
Intermittent access intake escalation 20.70.71.61.10.4-1.0-1.30.80.70.2
Intermitt. access day 1 inactive lever presses8.59.110.8-3.1-3.33.23.0-3.0-2.8-2.6
Intermitt. access day 15 inactive lever presses1.01.11.4-1.2-0.61.01.2-1.2-1.2-0.9
Intermitt. access escalation Index0.10.10.30.40.3-0.4-0.50.20.10.0
Intermittent access day 1 total infusions1.31.52.8-1.3-0.61.31.7-1.2-1.1-1.1
Intermittent access day 15 total infusions0.30.30.7-0.7-0.10.50.8-0.5-0.5-0.4
Intermittent access terminal intake (last 3 days)0.00.00.1-0.10.40.00.30.00.00.1
Intermittent access total infusions0.80.91.4-1.0-0.50.91.2-1.0-1.0-1.0
Intermittent access day 1 locomotion2.93.03.7-1.7-1.21.71.9-1.8-1.9-1.8
Intermittent access day 15 total locomotion3.33.54.1-1.9-1.62.01.8-2.0-1.9-1.8
Intermittent access total locomotion2.83.24.4-1.5-1.21.71.6-2.1-2.1-2.0
Intermittent access standard deviation0.10.10.20.10.2-0.2-0.10.30.30.4
Left kidney weight0.20.51.5-0.50.50.01.10.60.61.2
Right kidney weight0.20.72.3-1.00.10.51.50.20.21.0
Cocaine induced anxiety0.50.61.1-0.7-0.70.71.1-0.7-0.9-0.8
Post-drug Anxiety0.40.51.3-0.2-0.30.30.3-0.8-1.0-1.1
Baseline Anxiety1.31.44.81.50.8-1.1-2.20.60.60.3
Tail length0.51.45.10.3-0.10.0-0.3-1.3-1.7-2.3
Length with tail0.72.53.8-1.4-1.11.21.6-1.7-2.0-1.9
Length without tail1.32.87.5-2.1-1.51.72.7-1.1-1.0-0.5
Times rat made contact with spout0.80.91.71.21.1-1.1-1.30.70.40.1
Lifetime Intake0.80.91.7-1.1-0.41.01.3-1.0-0.8-0.7
Liver weight, left0.10.20.4-0.50.00.20.50.10.10.7
Liver weight, right0.61.02.6-1.4-0.81.11.6-0.4-0.30.2
Locomotor activity0.10.10.20.4-0.0-0.2-0.4-0.1-0.1-0.5
Locomotor testing distance1.22.02.9-1.3-1.71.41.1-1.4-1.3-1.6
Locomotor testing rearing0.71.11.8-0.8-1.21.00.6-1.2-1.2-1.3
Locomotion in novel chamber1.01.33.01.31.1-1.2-1.70.80.60.5
Locomotion in novel chamber post-restriction1.51.82.2-1.2-1.21.11.3-1.5-1.5-1.5
Fecal boli incidents, locomotor time 10.10.10.2-0.4-0.10.30.3-0.3-0.5-0.5
Change in fecal boli incidents, locomotor task0.20.20.7-0.3-0.90.40.3-0.3-0.2-0.3
Time >=10cm from walls, locomotor time 10.60.61.20.30.8-0.7-0.40.90.91.1
Bouts of movement, locomotor time 11.51.62.9-1.0-1.31.11.1-1.3-1.4-1.7
Total resting periods, locomotor time 10.60.71.5-0.7-0.80.60.6-0.8-1.0-1.2
Rest time, locomotor task time 10.30.30.7-0.8-0.70.70.6-0.4-0.4-0.1
Distance moved, locomotor task time 10.10.10.30.40.1-0.3-0.50.10.1-0.2
Vertical activity count, locomotor time 12.42.54.7-1.1-1.11.31.1-1.9-1.9-2.2
Time >=10cm from walls, locomotor time 21.61.72.2-1.2-1.31.21.5-1.2-1.2-1.3
Bouts of movement, locomotor time 20.10.10.30.2-0.1-0.3-0.40.50.3-0.0
Total resting periods, locomotor time 20.10.10.30.3-0.0-0.4-0.60.50.3-0.1
Rest time, locomotor task time 20.10.10.2-0.5-0.20.30.30.00.10.4
Distance moved, locomotor task time 20.00.00.10.30.0-0.1-0.3-0.0-0.1-0.3
Vertical activity count, locomotor time 21.51.72.1-1.2-1.21.31.1-1.3-1.4-1.4
Light reinforcement 10.61.11.7-1.3-1.11.21.3-0.9-0.7-0.6
Light reinforcement 20.20.20.5-0.20.20.00.5-0.6-0.7-0.6
Bone: marrow area2.75.814.92.93.9-2.9-2.41.10.71.1
Bone: maximum diameter0.40.73.40.51.9-0.80.10.1-0.20.6
Bone: maximum force3.66.27.8-2.7-1.92.62.8-2.7-2.6-1.7
Bone: maximum moment4.47.69.9-3.1-2.23.03.1-2.9-2.8-1.9
Mean time between licks in bursts0.10.10.10.30.4-0.2-0.3-0.2-0.2-0.3
Mean num. licks in bursts4.85.87.0-2.5-2.62.62.6-2.2-2.1-2.1
Cd content in liver4.95.47.3-2.3-2.72.42.0-2.3-2.1-2.4
Co content in liver0.50.50.90.40.4-0.8-0.60.90.91.0
Cu content in liver0.20.20.60.10.6-0.4-0.20.30.30.8
Fe content in liver5.36.410.5-2.8-2.22.53.2-2.4-2.3-1.9
K content in liver4.14.14.92.21.8-2.1-1.82.22.11.9
Mg content in liver1.01.01.81.40.9-1.2-1.21.00.80.5
Mn content in liver1.61.94.20.92.0-1.2-0.71.31.11.8
Na content in liver4.64.85.82.42.2-2.4-2.42.12.01.9
Rb content in liver0.81.01.21.10.8-1.1-1.01.01.10.8
Se content in liver2.02.43.92.01.6-1.7-1.81.41.20.7
Sr content in liver0.10.10.30.40.3-0.5-0.4-0.0-0.1-0.4
Zn content in liver1.11.22.20.90.7-1.0-0.71.31.41.5
Bone: minimum diameter0.40.83.50.71.9-0.8-0.50.1-0.20.7
Time in familiar zone, hab. session 13.33.14.0-1.9-1.82.01.9-1.7-1.6-1.5
Time in novel zone, hab. session 10.80.81.00.80.9-1.0-0.81.00.80.9
Total zone transitions, hab. session 11.52.05.4-0.5-1.30.8-0.0-1.7-1.8-2.3
Total locomotion distance, hab. session 12.13.04.1-1.5-1.71.61.2-2.0-2.0-2.0
Locomotion velocity, hab. session 11.52.13.6-1.1-1.31.20.9-1.8-1.8-1.9
Time in familiar zone, hab. session 20.20.20.40.70.2-0.5-0.40.60.60.4
Time in novel zone, hab. session 20.70.71.6-1.3-0.61.11.3-0.6-0.40.0
Total zone transitions, hab. session 20.50.71.9-0.2-0.80.3-0.2-1.0-1.1-1.4
Total locomotion distance, hab. session 20.20.30.6-0.3-0.60.40.1-0.6-0.6-0.8
Locomotion velocity, hab. session 20.00.10.10.1-0.2-0.1-0.3-0.2-0.2-0.4
Novel to familiar place preference ratio0.00.00.10.10.2-0.10.10.20.20.3
Novelty place preference0.10.10.20.10.3-0.10.20.30.30.4
Time in novel zone, NPP test0.10.10.5-0.4-0.20.30.7-0.2-0.2-0.0
Total zone transitions, NPP test3.85.410.6-1.6-2.21.80.8-2.8-2.9-3.3
Total locomotion distance, NPP test7.410.213.8-2.9-3.13.02.1-3.6-3.6-3.7
Locomotion velocity, NPP test4.96.99.8-2.3-2.62.41.6-3.0-3.0-3.1
Intraocular pressure0.50.71.1-0.7-0.60.60.4-1.0-1.1-1.0
Delta distance traveled before/after self-admin0.10.10.4-0.0-0.10.1-0.1-0.5-0.5-0.6
Delta ambulatory time before/after self-admin0.70.81.31.11.1-1.1-1.10.50.50.4
Parametrial fat weight0.30.51.3-0.4-0.60.30.2-0.8-1.0-1.2
Pavlov. Cond. lever latency0.00.00.10.10.3-0.1-0.20.30.20.2
Pavlov. Cond. magazine entry latency0.40.61.70.30.3-0.20.20.91.11.3
Pavlov. Cond. change in total contacts0.60.61.1-0.8-1.00.81.0-0.6-0.4-0.4
Pavlov. Cond. index score0.20.30.70.40.2-0.3-0.10.60.80.8
Pavlov. Cond. latency score0.20.30.60.50.3-0.3-0.30.60.70.8
Pavlov. Cond. lever contacts0.20.20.4-0.3-0.60.40.4-0.4-0.3-0.3
Pavlov. Cond. magazine entry number0.20.30.80.10.2-0.3-0.5-0.5-0.7-0.9
Pavlov. Cond. intertrial magazine entries1.41.73.2-1.0-1.31.00.9-1.4-1.4-1.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.40.3-0.3-0.10.70.80.9
Pavlov. Cond. response bias0.40.41.1-0.7-0.80.81.1-0.3-0.10.1
Pavlov. Cond. lever latency0.30.40.60.70.3-0.8-0.60.70.60.4
Pavlov. Cond. magazine entry latency0.20.20.3-0.5-0.20.50.2-0.5-0.5-0.5
Pavlov. Cond. change in total contacts0.10.20.3-0.4-0.40.50.4-0.5-0.4-0.5
Pavlov. Cond. index score0.30.40.6-0.6-0.30.60.5-0.7-0.7-0.7
Pavlov. Cond. latency score0.40.40.6-0.6-0.40.70.5-0.8-0.8-0.8
Pavlov. Cond. lever contacts0.20.30.4-0.5-0.20.60.4-0.6-0.6-0.5
Pavlov. Cond. magazine entry number0.60.71.00.80.8-0.9-0.60.90.81.0
Pavlov. Cond. intertrial magazine entries0.40.51.10.61.0-0.6-0.40.60.61.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.5-0.20.60.4-0.7-0.7-0.6
Pavlov. Cond. response bias0.20.30.5-0.6-0.20.70.6-0.6-0.5-0.4
Time in closed arm before self-admin0.80.91.30.71.1-1.0-0.71.00.91.0
Time in closed arm after self-admin3.83.85.51.52.1-1.9-1.42.12.12.3
Time in open arm before self-admin0.10.10.20.5-0.2-0.1-0.3-0.2-0.2-0.4
Time in open arm after self-admin2.93.27.1-1.1-1.51.40.5-2.2-2.2-2.7
Bone: periosteal estimation0.20.52.10.01.4-0.20.4-0.7-0.90.0
Bone: periosteal perimeter0.50.83.60.71.9-1.0-0.20.2-0.10.7
Bone: post-yield work0.20.30.50.40.4-0.3-0.2-0.6-0.7-0.7
Progressive ratio test 1 active lever presses1.41.52.2-1.2-1.11.21.5-1.2-1.2-1.1
Progressive ratio test 1 breakpoint2.12.23.2-1.5-1.31.51.8-1.4-1.4-1.3
Progressive ratio test 1 inactive lever presses2.12.33.7-1.8-1.41.71.9-1.4-1.3-0.7
Progressive ratio test 2 active lever presses0.40.40.8-0.6-0.20.50.9-0.7-0.7-0.7
Progressive ratio test 2 breakpoint0.30.30.4-0.5-0.10.40.7-0.6-0.6-0.6
Progressive ratio test 2 inactive lever presses1.01.22.4-1.2-0.61.11.6-1.1-1.0-0.7
Incentive Sensitization - Responses0.60.61.00.91.0-0.8-0.60.80.70.7
Incentive Sensitization - Breakpoint1.11.11.61.11.3-1.1-0.91.01.01.1
Sum of active levers in priming session hrs 5-60.30.30.8-0.3-0.90.5-0.5-0.4-0.4-0.5
Progressive ratio1.92.23.81.42.0-1.6-1.31.31.31.5
Food seeking constrained by brief footshock3.44.25.41.81.9-1.9-2.02.02.32.3
Seeking ratio, punishment vs. effort0.10.10.20.3-0.2-0.0-0.40.30.40.4
Retroperitoneal fat weight1.65.46.9-2.5-2.02.12.1-2.5-2.6-2.3
Reaction time number correct1.62.33.0-1.6-1.51.71.6-1.5-1.3-1.3
Reaction time mean minus median0.20.30.7-0.5-0.10.60.6-0.6-0.8-0.4
Reaction time mean minus median AUC0.30.31.1-0.70.20.71.0-0.2-0.20.5
Reaction time num false alarms0.30.40.80.30.7-0.60.10.60.70.9
Reaction time num false alarms AUC0.50.71.00.60.9-1.0-0.30.90.91.0
Reaction time trials correct on left1.62.33.0-1.6-1.51.71.6-1.5-1.3-1.3
Reaction time trials on left1.72.43.2-1.7-1.51.81.6-1.5-1.3-1.3
Reaction time mean0.40.51.0-0.6-0.30.70.6-0.8-1.0-0.8
Reaction time mean AUC0.50.71.2-0.9-0.50.90.8-0.9-1.1-0.8
Median of all reaction times0.30.40.7-0.6-0.30.60.5-0.7-0.8-0.7
Reaction time omissions0.10.20.5-0.60.20.30.7-0.2-0.30.2
Reaction time false alarm rate1.52.13.01.31.5-1.7-1.01.51.41.5
Reaction time premature initiation rate1.21.74.61.80.4-1.4-2.10.90.90.3
Reaction time premature initiations0.20.31.20.7-0.5-0.3-1.10.00.1-0.4
Std. dev. reaction times0.20.30.7-0.5-0.20.60.5-0.6-0.8-0.5
Reaction time trials completed1.72.43.2-1.7-1.51.81.6-1.5-1.3-1.3
Reaction time trials AUC1.72.43.2-1.7-1.51.81.6-1.5-1.3-1.3
Run reversals in cocaine runway, females0.00.00.10.2-0.3-0.1-0.10.20.4-0.1
Run reversals in cocaine runway, males0.00.00.20.30.0-0.1-0.40.1-0.00.1
Latency to leave start box in cocaine runway0.20.20.4-0.4-0.50.40.60.20.50.6
Latency to leave start box in cocaine runway, F0.80.92.2-1.1-1.51.11.1-0.5-0.2-0.4
Latency to leave start box in cocaine runway, M0.60.61.60.50.7-0.5-0.40.91.01.3
Std. dev. time between licks in bursts1.92.23.4-1.3-1.31.21.3-1.6-1.7-1.8
Total sessions with >9 infusions0.20.20.7-0.30.40.00.50.40.40.9
Short access day 1 total inactive lever presses1.82.02.7-1.4-1.31.61.3-1.7-1.5-1.2
Short access day 10 total inactive lever presses1.82.02.5-1.2-1.51.41.3-1.6-1.4-1.4
Short access day 1 total infusions0.30.30.9-0.60.00.50.90.00.20.7
Short access day 10 total infusions0.10.10.4-0.40.20.30.6-0.00.10.3
Short access total infusions0.50.51.2-1.0-0.20.81.1-0.6-0.5-0.2
Short access day 1 locomotion0.50.51.0-1.0-0.50.91.0-0.6-0.6-0.1
Short access day 10 total locomotion0.30.30.90.70.2-0.3-1.0-0.4-0.5-0.5
Short access total locomotion0.10.10.2-0.5-0.30.50.3-0.4-0.4-0.1
One hour access (0.3 mA shock)0.20.31.0-0.7-0.20.41.0-0.4-0.3-0.2
Compulsive drug intake2.72.73.2-1.7-1.81.51.8-1.6-1.5-1.7
One hour access (shock baseline)0.91.12.30.91.5-1.1-0.71.00.91.1
Social response proportion0.10.10.2-0.10.10.10.30.20.30.4
Social responses1.62.13.4-1.8-1.71.61.7-1.1-1.0-0.7
Social time0.70.91.2-1.1-0.70.91.1-1.0-1.1-0.7
Soleus weight1.33.74.11.91.9-2.0-2.02.01.91.9
Bone: stiffness0.50.71.0-0.9-0.40.91.0-1.0-1.0-0.6
Tibialis anterior weight0.31.22.00.90.8-0.9-0.51.31.41.4
Time to tail flick, vehicle, before self-admin2.02.02.9-1.2-1.21.11.6-1.4-1.6-1.7
Time to tail flick, vehicle, after self-admin1.61.72.81.01.2-1.2-0.71.71.61.5
Time to tail flick, test, before self-admin2.02.03.41.81.8-1.7-1.31.20.90.6
Time to tail flick, test, after self-admin0.50.51.20.90.6-0.8-1.10.60.40.4
Delta time to tail flick, vehicle, before/after SA1.21.21.81.00.7-0.8-1.11.31.41.2
Delta time to tail flick, test, before/after SA0.20.20.6-0.7-0.80.60.1-0.2-0.1-0.1
Tibia length0.41.03.8-0.20.8-0.10.41.01.21.9
Ambulatory time before self-admin0.40.40.90.3-0.0-0.3-0.10.90.91.0
Ambulatory time after self-admin0.70.81.11.00.7-0.9-0.90.90.90.7
Bone: tissue strength5.35.26.8-2.6-2.52.62.6-2.0-1.8-1.6
Total heroin consumption1.92.33.21.51.3-1.4-1.81.41.51.5
Bone: trabecular number0.10.10.70.00.4-0.10.30.30.20.8
Bone: trabecular spacing0.10.10.2-0.3-0.30.20.50.10.2-0.1
Bone: trabecular thickness0.10.10.20.40.4-0.3-0.5-0.2-0.4-0.1
Bone: trabecular tissue density0.20.31.00.1-0.20.2-0.1-0.6-0.7-1.0
Water consumed over 24 hours0.20.20.50.30.4-0.3-0.7-0.2-0.5-0.5
Number of responses in last shaping day0.10.10.2-0.30.30.30.4-0.3-0.50.1