Sox9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Sox9	0.15	0.07	3.3e-11	0.15	0.14	0.13	0.14	5.0e-12	2.8e-11	6.9e-11	3.8e-11
2	Brain	gene expression	Sox9	0.15	0.06	5.6e-17	0.18	0.17	0.17	0.18	1.7e-16	1.0e-15	1.1e-15	2.1e-16
3	IC	gene expression	Sox9	0.19	0.08	8.1e-07	0.08	0.13	0.13	0.13	2.5e-04	3.4e-06	6.3e-06	5.9e-06
4	Brain	mRNA stability	Sox9	0.03	0.02	6.5e-03	0.02	0.01	0	0.01	1.1e-02	2.8e-02	1.1e-01	3.1e-02
5	NAcc	gene expression	Sox9	0.15	0.06	0.0e+00	0.14	0.13	0.14	0.14	2.6e-20	1.3e-19	3.0e-21	2.8e-21
6	BLA	gene expression	Sox9	0.31	0.1	4.3e-15	0.27	0.3	0.29	0.3	9.8e-15	4.7e-16	1.3e-15	4.6e-16
7	PL	gene expression	Sox9	0.18	0.06	0.0e+00	0.18	0.18	0.19	0.18	2.1e-19	2.4e-19	6.9e-20	2.0e-19
8	IL	gene expression	Sox9	0.22	0.1	1.3e-03	0.06	0.09	0.01	0.05	1.8e-02	4.0e-03	1.5e-01	2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.2	0.5	0.4	0.7	0.1	0.7	-0.4	-0.5	0.2	0.4
Area under the delay curve	0.7	1.1	2.4	-1.5	-1.1	1.2	-1.0	1.1	0.9	-0.8	0.6
BMI with tail	0.3	1.1	1.8	1.0	1.3	-0.9	1.3	-1.0	-1.0	1.1	-0.1
BMI without tail	0.4	2.3	3.9	1.3	1.5	-1.5	1.3	-1.4	-1.5	1.4	-2.0
Body weight	0.8	3.4	4.6	1.4	1.8	-1.7	1.7	-2.0	-2.1	1.8	-2.1
Weight adjusted by age	0.6	1.6	2.7	1.3	0.9	-1.4	0.9	-1.4	-1.3	1.2	-1.6
Bone surface	0.1	0.2	0.6	-0.3	-0.3	0.8	-0.2	0.1	-0.3	-0.4	0.6
Bone volume	0.2	0.4	1.0	-0.5	-0.5	1.0	-0.5	0.3	0.1	-0.6	0.7
Breakpoint value in progressive ratio session	0.3	0.6	0.8	-0.8	-0.8	0.7	-0.7	0.6	0.8	-0.9	0.5
Number of licking bursts	2.2	6.7	8.1	-2.8	-2.8	2.4	-2.8	2.6	2.5	-2.7	1.9
Context. condit. distance diff. score	0.3	0.3	0.7	0.8	0.5	-0.7	0.3	-0.8	-0.5	0.4	-0.4
Locomotion velocity, session 1	0.1	0.2	0.5	-0.3	-0.7	0.2	-0.5	0.1	0.2	-0.4	-0.5
Locomotion distance, session 1	2.0	2.6	5.4	1.3	1.3	-1.8	1.1	-1.6	-1.7	1.4	-2.3
Locomotion velocity, session 2	0.3	0.3	0.7	0.6	0.3	-0.7	0.3	-0.6	-0.7	0.4	-0.9
Locomotion distance, session 2	2.5	3.5	7.1	1.8	1.3	-2.2	1.2	-2.0	-2.0	1.4	-2.7
Locomotion velocity, session 3	1.1	1.2	2.0	1.2	1.0	-1.1	0.9	-1.3	-1.0	0.8	-1.4
Locomotion distance, session 3	1.4	1.6	2.6	1.3	1.4	-1.6	1.1	-1.4	-1.2	0.7	-1.3
Stereotopy head waving bouts, day 3	0.3	0.4	1.2	-0.2	-0.3	0.8	0.0	0.6	0.7	-0.2	1.1
Stereotopy head waving duration, day 3	0.5	0.7	1.5	-0.6	-0.6	0.9	-0.4	1.0	1.0	-0.5	1.2
Locomotion velocity, session 7	1.8	2.0	2.6	1.4	1.2	-1.6	1.2	-1.6	-1.6	1.0	-1.5
Locomotion distance, session 7	4.4	5.6	9.2	2.3	1.8	-3.0	1.6	-2.5	-2.5	1.7	-3.0
Stereotopy head waving bouts, day 7	0.3	0.3	1.7	0.1	0.1	0.8	0.3	0.3	0.5	-0.1	1.3
Stereotopy head waving duration, day 7	1.8	2.2	6.6	-1.0	-0.8	1.9	-0.6	1.5	1.6	-1.1	2.6
Locomotion velocity, session 8	0.3	0.3	0.9	-0.3	-0.9	0.1	-0.9	0.2	0.3	-0.7	-0.1
Locomotion distance, session 8	3.0	4.4	6.5	2.2	1.6	-2.5	1.4	-2.3	-2.2	1.6	-2.5
Degree of sensitization distance	1.0	1.1	2.1	0.9	0.5	-1.2	0.5	-1.1	-1.2	1.0	-1.4
Degree of sensitization stereotypy	0.2	0.2	1.2	0.1	0.2	0.6	0.3	0.2	0.3	-0.0	1.1
Conditioned locomotion	0.1	0.2	0.3	-0.2	-0.3	0.5	-0.3	0.4	0.4	-0.4	0.6
Cocaine response after cond. corrected	1.0	1.5	2.1	-1.0	-1.0	1.1	-1.0	1.3	1.4	-1.3	1.4
Cocaine response after cond. not corrected	0.2	0.3	0.5	-0.4	-0.5	0.3	-0.6	0.5	0.6	-0.7	0.3
Cocaine response before conditioning	3.3	4.0	6.6	1.8	1.6	-2.1	1.5	-2.2	-2.2	1.8	-2.6
Saline control response	3.4	4.7	5.7	2.0	2.0	-2.0	2.0	-2.2	-2.3	2.4	-2.4
Bone: connectivity density	0.1	0.2	0.6	0.4	0.6	-0.0	0.8	-0.4	-0.5	0.2	0.4
Bone: cortical apparent density	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.0	0.0	0.2	0.0	-0.2
Bone: cortical area	4.8	7.8	10.3	3.2	3.2	-2.4	3.2	-2.7	-2.8	2.9	-1.5
Bone: cortical porosity	0.2	0.2	0.4	0.3	0.6	0.1	0.6	-0.4	-0.5	0.6	-0.0
Bone: cortical porosity	0.0	0.0	0.2	-0.1	0.1	0.4	0.1	0.0	-0.1	0.3	0.2
Bone: cortical thickness	15.8	26.4	34.7	5.7	5.9	-4.5	5.8	-5.0	-4.7	5.7	-3.4
Bone: cortical thickness	4.9	6.0	7.9	2.8	2.8	-2.0	2.7	-2.4	-2.3	2.8	-1.3
Bone: cortical tissue density	0.0	0.1	0.2	-0.3	-0.3	0.1	-0.2	0.2	0.4	-0.2	-0.1
Condit. Reinf. active minus inactive responses	1.4	1.6	2.4	1.4	1.1	-1.5	1.0	-1.4	-1.2	1.3	-1.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.1	1.1	0.6	-1.0	0.5	-0.8	-0.5	0.6	-0.4
Condit. Reinf. active responses	1.5	1.9	2.5	1.4	1.2	-1.6	1.2	-1.5	-1.3	1.4	-1.4
Condit. Reinf. inactive responses	0.8	1.1	1.7	0.8	0.9	-0.9	0.9	-1.1	-1.2	1.0	-1.3
Incentive salience index mean	0.6	0.8	1.2	0.9	0.7	-1.1	0.7	-0.9	-0.8	0.8	-0.9
Condit. Reinf. lever presses	0.7	1.1	1.4	0.9	1.0	-1.2	1.0	-1.1	-1.1	0.9	-1.2
Condit. Reinf. active minus inactive responses	0.4	0.5	1.2	1.1	0.7	-0.5	0.6	-0.8	-0.8	1.0	-0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.2	-0.2	-0.2	0.2	-0.3
Condit. Reinf. active responses	1.3	1.9	2.6	1.6	1.4	-1.2	1.4	-1.4	-1.5	1.5	-0.9
Condit. Reinf. inactive responses	3.0	4.4	5.6	2.2	2.4	-1.8	2.4	-2.1	-2.2	2.2	-1.4
Condit. Reinf. lever presses	1.4	2.0	2.5	1.5	1.3	-1.5	1.2	-1.4	-1.6	1.4	-1.5
Condit. Reinf. lever reinforcers received	1.8	2.6	3.3	1.8	1.5	-1.5	1.5	-1.6	-1.8	1.7	-1.3
Conditioned reinforcement - actives	0.0	0.2	0.3	0.5	0.5	-0.6	0.5	-0.1	-0.3	0.5	0.1
Conditioned reinforcement - inactives	0.8	2.2	2.9	1.6	1.5	-1.7	1.5	-1.5	-1.6	1.3	-1.1
Conditioned locomotion	0.3	0.4	0.6	0.7	0.8	-0.6	0.7	-0.5	-0.6	0.6	-0.3
Patch foraging indifference point 0 sec	2.5	7.1	8.2	2.5	2.7	-2.9	2.8	-2.5	-2.7	2.7	-2.4
Patch foraging indifference point AUC	0.1	0.2	0.5	-0.5	-0.6	-0.2	-0.6	0.2	0.3	-0.7	-0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.3	0.1	-0.1	0.1	-0.3	-0.3	0.5	0.1
Delay disc. indifference point, 16s delay	0.2	0.3	0.8	-0.9	-0.4	0.7	-0.5	0.6	0.4	-0.4	0.3
Delay disc. indifference point, 2s delay	1.7	1.9	3.1	-1.7	-1.7	1.7	-1.6	1.2	1.1	-1.2	0.5
Delay disc. indifference point, 24s delay	0.1	0.2	0.7	-0.9	-0.2	0.7	-0.2	0.4	0.2	-0.1	0.1
Delay disc. indifference point, 4s delay	2.5	2.7	3.7	-1.9	-1.6	1.9	-1.6	1.6	1.5	-1.2	1.6
Delay disc. indifference point, 8s delay	0.6	1.1	2.2	-1.5	-1.0	1.2	-0.8	1.1	1.0	-0.9	0.7
Indifference point function ln k	1.0	3.1	4.9	1.9	2.2	-1.4	2.2	-1.6	-1.7	2.0	-0.8
Indifference point function log k	1.0	3.1	4.9	1.9	2.2	-1.4	2.2	-1.6	-1.7	2.0	-0.8
Patch foraging total patch changes 0 sec	2.6	7.5	8.6	2.6	2.8	-2.9	2.9	-2.6	-2.7	2.8	-2.5
Patch foraging total patch changes 12 sec	3.2	4.2	5.1	1.9	1.9	-2.2	2.0	-2.1	-2.2	2.0	-2.2
Patch foraging total patch changes 18 sec	1.0	2.3	3.2	1.6	1.3	-1.8	1.3	-1.5	-1.4	1.4	-1.6
Patch foraging total patch changes 24 sec	0.7	2.5	3.1	1.5	1.5	-1.8	1.6	-1.5	-1.7	1.6	-1.4
Patch foraging total patch changes 6 sec	4.3	7.2	9.8	2.1	2.5	-3.1	2.5	-2.7	-2.8	2.5	-3.1
Patch foraging time to switch 0 sec	0.3	1.1	2.2	-1.1	-1.3	1.1	-1.5	0.8	0.8	-1.0	0.6
Patch foraging water rate 0 sec	0.3	1.3	1.7	1.2	1.3	-1.2	1.3	-1.0	-1.1	1.1	-1.0
Patch foraging water rate 12 sec	0.2	0.7	1.1	0.9	1.0	-0.6	0.8	-0.8	-0.8	1.1	-0.3
Patch foraging water rate 18 sec	0.2	0.5	1.3	0.7	1.2	-0.6	1.0	-0.5	-0.6	0.7	0.0
Patch foraging water rate 24 sec	4.0	5.7	7.7	2.8	2.8	-2.3	2.7	-2.3	-2.1	2.4	-1.4
Patch foraging water rate 6 sec	1.3	1.9	3.0	1.7	1.3	-1.2	1.2	-1.4	-1.3	1.6	-1.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.1	0.0	0.4	0.3	0.0	-0.0	-0.1	0.3
Distance traveled before self-admin	0.5	1.1	1.9	-0.9	-1.0	1.1	-0.8	1.1	1.3	-0.9	1.4
Distance traveled after self-admin	0.2	0.3	0.6	-0.5	-0.8	0.3	-0.6	0.6	0.7	-0.6	0.3
Extensor digitorum longus weight	0.0	0.1	0.3	-0.1	-0.3	0.0	-0.5	0.1	0.2	-0.4	0.0
Bone: elastic displacement	5.3	6.7	9.4	2.7	3.0	-2.1	3.1	-2.6	-2.4	2.8	-1.8
Bone: elastic work	8.8	11.5	16.0	3.7	3.9	-2.8	4.0	-3.4	-3.3	3.5	-2.1
Bone: endosteal estimation	2.6	6.3	9.5	-2.5	-3.1	2.1	-3.0	2.4	1.8	-3.0	1.9
Bone: endosteal perimeter	3.9	9.5	12.8	-3.3	-3.5	2.8	-3.4	3.0	2.3	-3.6	2.4
Epididymis fat weight	2.0	9.9	16.7	2.7	2.6	-3.3	2.5	-3.3	-3.3	3.0	-4.1
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.1	0.1	-0.2	0.0	-0.1	-0.0	-0.3	-0.2
Delta time in open arm before/after self-admin	3.3	3.9	5.0	2.0	1.9	-1.6	1.9	-2.1	-2.0	2.2	-2.0
Diff in mean of infusions in LGA sessions	0.2	0.4	0.7	-0.8	-0.5	0.4	-0.4	0.6	0.8	-0.6	0.6
Delay discount exponential model param	1.2	1.6	3.2	1.8	1.2	-1.5	1.1	-1.3	-1.1	1.0	-0.8
Extinction: sum of active levers before priming	0.9	1.4	1.7	1.1	1.1	-1.3	1.2	-1.2	-1.2	1.0	-1.2
Active lever presses in extinction session 6	0.9	0.9	1.4	-1.0	-1.0	1.0	-1.2	0.8	1.0	-1.2	0.5
Bone: final force	3.6	5.9	8.7	3.0	2.7	-2.1	2.8	-2.4	-2.5	2.5	-1.1
Bone: final moment	4.7	7.6	10.7	3.3	3.1	-2.3	3.2	-2.7	-2.8	2.8	-1.2
Food consumed during 24 hour testing period	0.1	0.1	0.3	-0.2	-0.6	0.4	-0.5	0.2	0.1	-0.4	0.1
Glucose	0.1	0.1	0.1	-0.2	-0.3	0.4	-0.2	0.3	0.4	-0.4	0.2
Heart weight	4.3	6.9	8.5	2.3	2.7	-2.5	2.7	-2.8	-2.9	2.7	-2.3
Delay discount hyperbolic model param	1.6	2.1	3.8	1.9	1.5	-1.7	1.3	-1.5	-1.2	1.1	-1.0
Intermittent access intake day 1-15 change	0.0	0.1	0.3	0.4	0.5	-0.3	0.3	-0.1	-0.0	0.2	-0.1
Intermittent access intake escalation	0.0	0.2	0.5	0.6	0.7	-0.4	0.5	-0.2	-0.1	0.3	-0.1
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.2	-0.2	0.3	-0.4	0.4	0.6	-0.3	0.2
Intermitt. access day 1 inactive lever presses	1.0	12.5	14.3	3.8	3.7	-3.5	3.7	-3.7	-3.6	3.3	-3.0
Intermitt. access day 15 inactive lever presses	0.1	0.5	0.8	0.4	0.7	-0.5	0.9	-0.7	-0.8	0.6	-0.7
Intermitt. access escalation Index	0.1	0.3	0.5	-0.3	-0.4	0.7	-0.3	0.3	0.4	-0.7	0.7
Intermittent access day 1 total infusions	0.9	2.7	3.7	1.4	1.5	-1.8	1.7	-1.6	-1.8	1.9	-1.5
Intermittent access day 15 total infusions	1.0	2.5	3.1	1.5	1.7	-1.7	1.8	-1.4	-1.5	1.7	-1.3
Intermittent access terminal intake (last 3 days)	0.6	1.1	1.5	0.9	1.2	-1.2	1.1	-0.9	-1.0	1.2	-0.8
Intermittent access total infusions	2.3	2.7	3.9	1.4	1.5	-2.0	1.6	-1.5	-1.7	1.7	-1.6
Intermittent access day 1 locomotion	1.2	2.3	2.8	1.3	1.5	-1.5	1.6	-1.5	-1.7	1.6	-1.4
Intermittent access day 15 total locomotion	1.5	5.6	7.1	2.1	2.7	-2.5	2.4	-2.3	-2.4	2.4	-2.1
Intermittent access total locomotion	3.3	3.9	4.9	1.8	2.0	-2.2	1.9	-1.9	-2.1	1.9	-1.9
Intermittent access standard deviation	0.0	0.1	0.3	0.1	0.5	-0.4	0.4	0.1	0.0	0.1	0.2
Left kidney weight	0.0	0.1	0.5	0.1	0.0	0.4	0.1	0.1	-0.1	0.3	0.7
Right kidney weight	0.0	0.2	0.4	0.2	0.6	0.1	0.5	-0.2	-0.2	0.7	0.5
Cocaine induced anxiety	0.0	0.1	0.3	0.2	-0.2	-0.1	-0.2	-0.4	-0.5	0.5	-0.5
Post-drug Anxiety	0.5	0.5	1.5	0.7	0.2	-0.7	0.1	-0.8	-0.8	0.5	-1.2
Baseline Anxiety	0.1	0.2	0.6	0.4	0.3	-0.6	0.1	-0.3	-0.2	-0.2	-0.8
Tail length	0.5	2.8	9.6	1.3	1.0	-1.5	0.9	-1.5	-1.7	1.4	-3.1
Length with tail	0.3	1.2	4.0	0.4	0.5	-0.7	0.5	-1.2	-1.3	1.1	-2.0
Length without tail	0.0	0.2	0.5	-0.7	-0.1	0.6	0.0	-0.2	-0.2	0.2	0.7
Times rat made contact with spout	0.8	0.9	1.8	-1.3	-1.2	0.9	-1.1	1.0	0.9	-0.7	0.1
Lifetime Intake	2.1	2.6	3.5	1.4	1.6	-1.9	1.7	-1.4	-1.7	1.7	-1.3
Liver weight, left	0.6	1.0	2.0	0.5	1.1	-0.7	1.1	-1.1	-1.4	0.8	-1.1
Liver weight, right	1.6	2.8	5.4	1.5	2.2	-1.2	2.3	-1.3	-1.6	1.9	-0.9
Locomotor activity	0.1	0.1	0.2	0.0	-0.5	-0.4	-0.5	-0.2	-0.1	-0.1	-0.4
Locomotor testing distance	0.8	2.1	3.1	1.5	1.0	-1.8	1.0	-1.6	-1.4	1.3	-1.7
Locomotor testing rearing	0.4	1.6	2.4	1.2	1.1	-1.4	1.0	-1.5	-1.3	1.1	-1.6
Locomotion in novel chamber	1.0	1.3	3.5	-0.4	-1.4	1.1	-1.9	0.9	0.9	-1.4	0.6
Locomotion in novel chamber post-restriction	0.3	0.8	1.4	0.8	0.9	-0.9	0.8	-0.9	-1.2	0.7	-0.9
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.0	0.2	-0.4	0.1	-0.1	-0.2	0.2	-0.4
Change in fecal boli incidents, locomotor task	0.1	0.2	0.3	0.6	0.1	-0.4	0.2	-0.6	-0.4	0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.5	0.6	1.4	-0.5	-0.7	0.7	-0.5	0.9	0.9	-0.8	1.2
Bouts of movement, locomotor time 1	0.9	1.2	2.6	0.9	1.0	-1.3	0.9	-0.9	-1.0	0.9	-1.6
Total resting periods, locomotor time 1	0.4	0.5	1.3	0.5	0.7	-0.7	0.6	-0.5	-0.6	0.6	-1.2
Rest time, locomotor task time 1	0.0	0.0	0.2	0.1	0.0	0.2	-0.1	0.0	0.0	0.2	0.4
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.2	-0.2	0.2	0.1	0.1	0.2	-0.3	-0.2
Vertical activity count, locomotor time 1	0.5	3.2	5.0	1.6	1.5	-2.0	1.7	-1.8	-1.8	1.5	-2.2
Time >=10cm from walls, locomotor time 2	0.3	0.9	1.4	0.9	0.8	-0.9	0.8	-1.0	-0.9	1.0	-1.2
Bouts of movement, locomotor time 2	0.0	0.1	0.2	-0.4	-0.3	0.3	-0.4	0.5	0.4	-0.2	-0.2
Total resting periods, locomotor time 2	0.0	0.2	0.3	-0.5	-0.3	0.3	-0.4	0.5	0.5	-0.3	-0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	0.4	0.1	0.0	0.1	-0.1	-0.0	0.3	0.3
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.3	-0.1	0.0	0.0	0.1	0.0	-0.3	-0.3
Vertical activity count, locomotor time 2	0.8	1.9	2.3	1.3	1.3	-1.5	1.4	-1.3	-1.4	1.2	-1.5
Light reinforcement 1	0.3	1.5	1.9	1.2	1.3	-1.4	1.3	-1.2	-1.2	1.2	-0.8
Light reinforcement 2	0.1	0.3	0.7	0.2	0.3	-0.6	0.4	-0.7	-0.8	0.5	-0.7
Bone: marrow area	2.4	5.9	9.2	-2.4	-3.0	2.0	-2.9	2.3	1.7	-2.9	1.8
Bone: maximum diameter	0.3	0.6	1.5	-0.6	-0.8	0.7	-0.7	0.8	0.3	-0.7	1.2
Bone: maximum force	2.6	5.2	7.5	2.7	2.4	-2.1	2.4	-2.4	-2.5	2.2	-1.3
Bone: maximum moment	3.6	6.7	9.3	3.0	2.8	-2.3	2.9	-2.6	-2.7	2.6	-1.5
Mean time between licks in bursts	0.0	0.0	0.0	-0.1	-0.2	0.0	-0.2	-0.0	-0.1	-0.2	-0.1
Mean num. licks in bursts	1.9	5.2	6.2	2.3	2.3	-2.2	2.4	-2.3	-2.2	2.5	-2.1
Cd content in liver	2.4	2.6	3.5	1.7	1.4	-1.7	1.4	-1.7	-1.6	1.5	-1.9
Co content in liver	1.4	1.7	2.8	-1.6	-0.7	1.5	-0.7	1.4	1.3	-1.2	1.7
Cu content in liver	1.1	1.2	2.2	-1.3	-0.7	1.2	-0.7	1.2	1.1	-1.1	1.5
Fe content in liver	1.8	2.2	3.1	1.4	1.8	-1.5	1.8	-1.5	-1.5	1.4	-1.1
K content in liver	3.1	3.0	3.6	-1.9	-1.9	1.7	-1.9	1.8	1.8	-1.6	1.3
Mg content in liver	1.4	1.5	2.2	-1.5	-1.3	1.1	-1.3	1.3	1.3	-1.2	0.8
Mn content in liver	1.0	1.1	2.3	-1.1	-0.7	1.4	-0.7	1.1	0.9	-0.8	1.5
Na content in liver	5.2	5.9	7.0	-2.4	-2.5	2.3	-2.5	2.4	2.5	-2.6	2.1
Rb content in liver	0.1	0.1	0.3	-0.0	-0.6	0.0	-0.6	0.2	0.4	-0.2	0.3
Se content in liver	1.6	1.9	3.3	-1.4	-1.8	1.0	-1.8	1.3	1.4	-1.3	0.4
Sr content in liver	0.1	0.1	0.3	-0.6	-0.2	-0.2	-0.2	0.1	-0.0	-0.4	-0.3
Zn content in liver	1.8	2.0	2.6	-1.4	-1.2	1.5	-1.2	1.5	1.5	-1.5	1.6
Bone: minimum diameter	0.4	0.8	1.5	-0.7	-0.8	1.0	-0.7	0.8	0.5	-1.1	1.2
Time in familiar zone, hab. session 1	2.8	3.0	3.8	1.8	1.7	-1.6	1.9	-1.7	-1.8	2.0	-1.4
Time in novel zone, hab. session 1	0.7	0.8	1.2	-0.9	-0.8	0.9	-0.8	0.8	1.0	-1.1	0.9
Total zone transitions, hab. session 1	1.1	1.5	4.8	1.0	0.5	-1.3	0.5	-1.4	-1.3	0.8	-2.2
Total locomotion distance, hab. session 1	1.9	2.7	3.9	1.6	1.5	-1.8	1.4	-1.8	-1.8	1.3	-2.0
Locomotion velocity, hab. session 1	1.3	1.8	3.5	1.1	1.2	-1.5	1.0	-1.5	-1.5	1.0	-1.9
Time in familiar zone, hab. session 2	0.2	0.3	0.5	-0.5	-0.7	0.5	-0.5	0.5	0.5	-0.4	0.3
Time in novel zone, hab. session 2	0.6	0.7	1.3	1.1	1.1	-0.7	1.0	-0.6	-0.7	0.8	0.1
Total zone transitions, hab. session 2	0.3	0.4	1.5	0.4	0.1	-0.8	-0.0	-0.7	-0.7	0.2	-1.2
Total locomotion distance, hab. session 2	0.2	0.2	0.7	0.4	0.3	-0.6	0.1	-0.5	-0.5	0.1	-0.8
Locomotion velocity, hab. session 2	0.0	0.1	0.2	-0.0	-0.1	-0.2	-0.3	-0.1	-0.1	-0.3	-0.4
Novel to familiar place preference ratio	0.0	0.1	0.1	-0.3	0.0	0.3	0.0	0.3	0.2	-0.2	0.4
Novelty place preference	0.1	0.1	0.2	-0.3	-0.0	0.4	-0.0	0.3	0.3	-0.3	0.5
Time in novel zone, NPP test	0.1	0.1	0.2	0.2	0.4	-0.2	0.4	-0.1	-0.2	0.2	-0.0
Total zone transitions, NPP test	3.1	4.5	9.3	2.1	1.4	-2.3	1.1	-2.4	-2.2	1.8	-3.1
Total locomotion distance, NPP test	7.0	9.7	14.0	3.1	2.7	-3.4	2.4	-3.3	-3.2	2.8	-3.7
Locomotion velocity, NPP test	4.6	6.5	10.0	2.5	2.2	-2.7	1.9	-2.7	-2.7	2.3	-3.2
Intraocular pressure	0.6	0.9	1.4	0.6	1.2	-1.0	1.1	-0.9	-1.1	0.6	-1.0
Delta distance traveled before/after self-admin	0.3	0.3	0.7	0.4	0.3	-0.9	0.1	-0.6	-0.6	0.3	-0.8
Delta ambulatory time before/after self-admin	0.3	0.5	1.4	-0.7	-0.8	0.2	-1.2	0.4	0.4	-0.8	0.2
Parametrial fat weight	0.2	0.4	0.7	0.7	0.5	-0.6	0.6	-0.8	-0.7	0.2	-0.7
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	-0.4	-0.1	-0.2	0.2	0.1	-0.0	0.2
Pavlov. Cond. magazine entry latency	0.4	0.5	1.4	-0.4	-0.4	0.9	-0.5	0.6	0.8	-0.3	1.2
Pavlov. Cond. change in total contacts	0.5	0.6	1.1	0.7	1.0	-0.6	0.8	-0.8	-0.7	0.7	-0.5
Pavlov. Cond. index score	0.2	0.2	0.5	-0.5	-0.2	0.6	-0.3	0.4	0.6	-0.3	0.7
Pavlov. Cond. latency score	0.2	0.3	0.5	-0.5	-0.2	0.7	-0.4	0.5	0.6	-0.4	0.6
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.2	0.7	-0.2	0.5	-0.5	-0.4	0.3	-0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	-0.1	0.0	-0.4	0.1	-0.1	-0.4	-0.2	-0.7
Pavlov. Cond. intertrial magazine entries	1.9	2.3	3.6	1.1	1.5	-1.6	1.7	-1.3	-1.5	1.3	-1.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.6	-0.6	-0.2	0.7	-0.3	0.6	0.7	-0.4	0.8
Pavlov. Cond. response bias	0.3	0.3	0.7	0.6	0.8	-0.4	0.7	-0.6	-0.4	0.7	-0.1
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.7	-0.6	0.6	-0.5	0.5	0.6	-0.7	0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.4	0.3	-0.7	0.2	-0.3	-0.3	0.1	-0.4
Pavlov. Cond. change in total contacts	0.2	0.4	0.9	1.0	0.4	-0.8	0.3	-0.6	-0.6	0.4	-0.6
Pavlov. Cond. index score	0.3	0.4	0.8	0.8	0.6	-0.9	0.5	-0.6	-0.7	0.6	-0.7
Pavlov. Cond. latency score	0.3	0.5	0.8	0.8	0.6	-0.9	0.5	-0.6	-0.7	0.5	-0.7
Pavlov. Cond. lever contacts	0.4	0.6	0.7	0.8	0.8	-0.8	0.7	-0.7	-0.8	0.9	-0.7
Pavlov. Cond. magazine entry number	0.2	0.3	0.9	-0.8	-0.4	0.9	-0.4	0.5	0.5	-0.3	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	-0.5	-0.2	0.4	-0.2	0.3	0.3	-0.4	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	0.7	0.5	-0.7	0.4	-0.5	-0.6	0.5	-0.5
Pavlov. Cond. response bias	0.4	0.6	1.0	1.0	0.7	-0.9	0.6	-0.7	-0.8	0.8	-0.6
Time in closed arm before self-admin	0.1	0.1	0.4	-0.3	-0.6	0.2	-0.4	0.5	0.3	-0.1	0.3
Time in closed arm after self-admin	1.8	2.0	2.9	-1.3	-1.3	1.2	-1.3	1.6	1.5	-1.5	1.7
Time in open arm before self-admin	0.1	0.1	0.4	-0.5	-0.2	0.2	-0.6	0.0	0.2	-0.4	-0.2
Time in open arm after self-admin	3.5	3.9	7.6	1.6	1.7	-1.8	1.5	-2.2	-2.1	1.9	-2.8
Bone: periosteal estimation	0.0	0.1	0.4	0.1	-0.2	0.2	-0.1	0.1	-0.3	-0.3	0.6
Bone: periosteal perimeter	0.6	1.1	2.2	-1.1	-0.9	1.2	-0.8	1.1	0.6	-1.0	1.5
Bone: post-yield work	0.1	0.1	0.2	-0.1	-0.4	-0.4	-0.4	-0.1	-0.3	-0.4	-0.5
Progressive ratio test 1 active lever presses	1.2	2.1	2.4	1.4	1.4	-1.5	1.3	-1.4	-1.5	1.6	-1.4
Progressive ratio test 1 breakpoint	1.4	2.4	2.8	1.5	1.5	-1.6	1.4	-1.5	-1.6	1.7	-1.6
Progressive ratio test 1 inactive lever presses	1.3	3.4	4.3	1.9	2.1	-1.8	2.1	-1.8	-1.9	1.9	-1.2
Progressive ratio test 2 active lever presses	0.6	0.8	1.5	0.6	1.2	-0.9	1.2	-0.7	-0.9	0.9	-0.6
Progressive ratio test 2 breakpoint	0.6	0.7	1.3	0.6	1.1	-0.9	1.1	-0.6	-0.9	0.8	-0.5
Progressive ratio test 2 inactive lever presses	0.8	2.5	3.3	1.5	1.7	-1.7	1.8	-1.5	-1.6	1.6	-1.2
Incentive Sensitization - Responses	0.1	0.3	0.8	-0.6	-0.2	0.5	0.0	0.7	0.5	-0.5	0.9
Incentive Sensitization - Breakpoint	0.2	0.5	1.2	-0.8	-0.3	0.6	-0.1	0.8	0.7	-0.7	1.1
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.8	0.7	0.8	-0.8	0.8	-0.9	-0.7	0.5	-0.7
Progressive ratio	0.5	1.4	1.7	-1.2	-1.1	1.3	-0.8	1.3	1.1	-1.2	1.3
Food seeking constrained by brief footshock	3.2	4.0	5.7	-1.9	-1.9	2.2	-1.7	1.9	2.0	-1.9	2.4
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	-0.0	-0.1	0.2	-0.4	0.1	0.3	-0.1	0.4
Retroperitoneal fat weight	2.9	13.1	18.5	3.2	3.4	-3.7	3.3	-3.8	-3.8	3.2	-4.3
Reaction time number correct	0.6	2.1	2.8	1.7	1.5	-1.4	1.5	-1.4	-1.4	1.5	-1.2
Reaction time mean minus median	0.1	0.5	0.7	0.6	0.9	-0.6	0.8	-0.6	-0.7	0.6	-0.5
Reaction time mean minus median AUC	0.0	0.3	0.6	0.5	0.8	-0.3	0.8	-0.2	-0.3	0.4	0.5
Reaction time num false alarms	0.3	0.5	1.0	-1.0	-0.7	0.7	-0.4	0.6	0.6	-0.5	1.0
Reaction time num false alarms AUC	0.4	1.0	1.8	-1.3	-1.0	1.0	-0.8	1.0	0.9	-0.8	1.1
Reaction time trials correct on left	0.6	2.1	2.8	1.7	1.5	-1.4	1.5	-1.4	-1.4	1.5	-1.2
Reaction time trials on left	0.6	2.2	2.8	1.7	1.5	-1.4	1.5	-1.4	-1.4	1.5	-1.2
Reaction time mean	0.3	0.7	1.0	0.6	0.8	-1.0	0.8	-0.8	-0.9	0.8	-0.8
Reaction time mean AUC	0.4	0.9	1.3	0.8	1.0	-1.1	1.1	-0.9	-1.0	0.9	-0.8
Median of all reaction times	0.3	0.5	0.9	0.5	0.6	-0.9	0.7	-0.7	-0.8	0.7	-0.7
Reaction time omissions	0.1	0.1	0.4	0.1	0.5	-0.4	0.6	-0.3	-0.4	0.3	0.2
Reaction time false alarm rate	1.9	2.6	4.1	-2.0	-1.6	1.7	-1.4	1.6	1.5	-1.5	1.7
Reaction time premature initiation rate	0.6	1.0	2.0	-1.0	-1.2	0.9	-1.4	0.7	0.9	-1.1	-0.0
Reaction time premature initiations	0.0	0.1	0.5	0.1	-0.2	-0.0	-0.4	-0.1	0.0	-0.2	-0.7
Std. dev. reaction times	0.1	0.3	0.6	0.5	0.7	-0.6	0.7	-0.5	-0.6	0.5	-0.4
Reaction time trials completed	0.6	2.2	2.8	1.7	1.5	-1.4	1.5	-1.4	-1.4	1.5	-1.2
Reaction time trials AUC	0.7	2.3	3.0	1.7	1.6	-1.5	1.6	-1.4	-1.4	1.5	-1.3
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.3	-0.2	-0.0	-0.3	0.1	0.2	0.1	-0.0
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.5	-0.3	0.4	-0.7	0.3	0.4	-0.3	0.3
Latency to leave start box in cocaine runway	0.1	0.2	0.5	0.7	0.4	-0.5	0.5	-0.4	-0.3	0.5	0.2
Latency to leave start box in cocaine runway, F	1.6	2.1	2.7	1.6	1.4	-1.6	1.4	-1.5	-1.3	1.4	-1.1
Latency to leave start box in cocaine runway, M	1.8	1.8	3.8	-1.1	-1.1	1.2	-1.1	1.4	1.4	-1.2	2.0
Std. dev. time between licks in bursts	1.4	2.6	3.9	1.4	1.4	-1.8	1.4	-1.7	-1.7	1.4	-2.0
Total sessions with >9 infusions	0.4	0.5	1.0	0.5	0.9	-0.5	1.0	-0.4	-0.6	0.9	0.1
Short access day 1 total inactive lever presses	0.8	1.6	2.2	1.2	1.5	-1.4	1.4	-1.3	-1.4	1.2	-0.9
Short access day 10 total inactive lever presses	0.2	1.1	1.4	1.1	0.9	-1.0	0.9	-1.2	-1.2	0.8	-1.2
Short access day 1 total infusions	0.3	0.5	1.3	0.5	1.0	-0.5	1.2	-0.4	-0.6	0.8	0.6
Short access day 10 total infusions	0.1	0.2	0.6	0.4	0.4	-0.8	0.5	-0.3	-0.5	0.7	-0.1
Short access total infusions	0.6	0.9	1.6	0.7	1.1	-1.0	1.2	-0.8	-1.0	1.1	-0.2
Short access day 1 locomotion	0.6	1.0	1.7	0.7	1.2	-0.9	1.1	-0.9	-1.1	1.3	-0.6
Short access day 10 total locomotion	0.0	0.2	0.6	-0.2	-0.5	0.3	-0.8	0.2	0.2	-0.5	0.1
Short access total locomotion	0.2	0.2	0.4	0.4	0.6	-0.4	0.5	-0.5	-0.5	0.6	-0.2
One hour access (0.3 mA shock)	0.3	0.3	0.6	0.6	0.7	-0.5	0.8	-0.4	-0.6	0.5	-0.2
Compulsive drug intake	0.3	0.4	0.7	0.7	0.5	-0.6	0.5	-0.8	-0.8	0.4	-0.6
One hour access (shock baseline)	0.0	0.1	0.1	-0.4	-0.0	0.1	0.1	0.4	0.2	-0.0	0.4
Social response proportion	0.0	0.1	0.3	-0.1	-0.1	0.2	0.1	0.3	0.1	0.2	0.5
Social responses	1.6	2.1	3.1	1.5	1.7	-1.3	1.8	-1.4	-1.4	1.6	-0.6
Social time	0.4	0.7	1.4	0.4	1.0	-0.7	1.2	-0.7	-0.9	0.9	-0.4
Soleus weight	1.9	5.6	6.2	-2.4	-2.4	2.2	-2.2	2.4	2.4	-2.5	2.4
Bone: stiffness	0.2	0.4	0.9	0.9	0.6	-0.7	0.5	-0.6	-0.8	0.5	-0.2
Tibialis anterior weight	0.5	1.8	2.8	-1.3	-1.2	1.4	-1.2	1.3	1.3	-1.2	1.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.6	0.3	0.5	-0.4	0.5	-0.4	-0.5	0.1	-0.8
Time to tail flick, vehicle, after self-admin	2.3	4.7	5.7	-2.3	-2.0	2.2	-1.7	2.4	2.3	-1.9	2.3
Time to tail flick, test, before self-admin	0.6	0.7	1.3	-1.1	-0.9	1.0	-1.0	0.6	0.5	-0.7	0.2
Time to tail flick, test, after self-admin	0.8	0.8	1.4	-1.2	-0.8	1.1	-1.0	0.9	0.8	-0.8	0.5
Delta time to tail flick, vehicle, before/after SA	1.2	1.3	1.9	-1.2	-1.1	1.0	-0.9	1.3	1.4	-0.9	1.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	0.1	-0.0	0.1	0.2	0.2	-0.0	0.2
Tibia length	0.3	0.8	3.4	-0.4	-0.0	1.2	0.1	0.8	0.6	0.0	1.8
Ambulatory time before self-admin	0.1	0.3	0.6	-0.2	-0.4	0.5	-0.2	0.6	0.8	-0.3	0.8
Ambulatory time after self-admin	0.1	0.2	0.4	-0.4	-0.7	0.2	-0.6	0.4	0.4	-0.4	0.1
Bone: tissue strength	5.3	5.6	6.9	2.6	2.6	-2.2	2.6	-2.4	-2.2	2.4	-1.7
Total heroin consumption	1.4	1.6	2.2	-1.3	-1.3	1.3	-1.0	1.1	1.3	-1.3	1.5
Bone: trabecular number	0.1	0.1	0.6	0.2	0.2	0.5	0.3	-0.1	-0.2	0.1	0.8
Bone: trabecular spacing	0.0	0.0	0.2	0.1	0.0	-0.4	-0.0	-0.0	0.0	0.3	-0.3
Bone: trabecular thickness	0.0	0.0	0.2	0.0	-0.0	0.4	0.1	-0.1	-0.1	-0.2	0.1
Bone: trabecular tissue density	0.1	0.2	1.0	-0.1	-0.4	-0.3	-0.3	-0.1	-0.3	0.2	-1.0
Water consumed over 24 hours	0.0	0.1	0.4	-0.1	-0.0	-0.0	-0.0	-0.2	-0.2	-0.1	-0.7
Number of responses in last shaping day	0.1	0.1	0.2	0.2	0.5	-0.3	0.2	-0.3	-0.4	0.2	-0.2